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Articles published in Gut

Retrieve available abstracts of 77 articles:
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Single Articles


    August 2026
  1. THIMME R, Hofmann M, Bertoletti A, Le Bert N, et al
    Decoding HBV-specific adaptive immunity: from natural clearance to cure.
    Gut. 2026;75:1857-1866.
    PubMed     Abstract available


    July 2026
  2. MAO T, Wu Y, Gu Z, Abulaiti A, et al
    DR1-DR2 enrichment in HBeAg-negative chronic hepatitis B: integration hotspot or survivor signature?
    Gut. 2026 Jul 15:gutjnl-2026-339913. doi: 10.1136/gutjnl-2026-339913.
    PubMed    


  3. WU JF, Hsu CT, Tai CS, Chang KC, et al
    Circulating HBV RNA and HBsAg seroconversion in patients with chronic HBV infection: a long-term follow-up study starting from childhood in Taiwan.
    Gut. 2026;75:1565-1572.
    PubMed     Abstract available


    June 2026
  4. WANG B, Li Y, Li F, Feng Y, et al
    Functional anti-preS1 antibody responses associated with viral control in chronic hepatitis B.
    Gut. 2026 Jun 22:gutjnl-2025-337810. doi: 10.1136/gutjnl-2025-337810.
    PubMed     Abstract available


  5. KAMAL H, Degasperi E, Radu M, Sambarino D, et al
    Course and clinical outcomes of chronic hepatitis delta: a longitudinal analysis of 565 patients from the D-SOLVE and HDV-1000 consortia.
    Gut. 2026 Jun 17:gutjnl-2025-336234. doi: 10.1136/gutjnl-2025-336234.
    PubMed     Abstract available


  6. BOETTLER T, Neumann-Haefelin C
    Hepatitis B immunoglobulins after liver transplantation: essential early, optional later?
    Gut. 2026 Jun 11:gutjnl-2026-339122. doi: 10.1136/gutjnl-2026-339122.
    PubMed    


  7. PREECHANUKUL A, Alrubayyi A, Sun B, Arbe-Barnes E, et al
    Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.
    Gut. 2026;75:1397-1410.
    PubMed     Abstract available


    May 2026
  8. CAO M, Wei F, Georges D, Alberts CJ, et al
    Hepatocellular carcinoma attributable to hepatitis B, hepatitis C and other risk factors at global, regional and national levels: an updated systematic review and meta-analysis.
    Gut. 2026 May 14:gutjnl-2025-337838. doi: 10.1136/gutjnl-2025-337838.
    PubMed     Abstract available


  9. CHEN X, Liu X, Xu T, Wang Y, et al
    Engineered virus-hunter vaccine overcomes HBV immune tolerance.
    Gut. 2026;75:1211-1225.
    PubMed     Abstract available


  10. BERTOLETTI A, Le Bert N
    CD16(+) gammadelta T cells and antibody-dependent cellular cytotoxicity: a new axis of immune control in hepatitis B virus infection?
    Gut. 2026 May 11:gutjnl-2026-338954. doi: 10.1136/gutjnl-2026-338954.
    PubMed    


    April 2026
  11. MOHAMED A, Guerra Veloz M, Greenland L, Francois S, et al
    The UK experience with hepatitis B immunoglobulin use following liver transplantation: wide variation in practice despite evidence supporting cost-effective HBIG-free prophylaxis.
    Gut. 2026 Apr 27:gutjnl-2025-337965. doi: 10.1136/gutjnl-2025-337965.
    PubMed     Abstract available


  12. LAU DT, Kim ES, Wang Z, King WC, et al
    Differential intrahepatic integrated HBV DNA patterns between HBeAg-positive and HBeAg-negative chronic hepatitis B.
    Gut. 2026 Apr 24:gutjnl-2025-337127. doi: 10.1136/gutjnl-2025-337127.
    PubMed     Abstract available


  13. SCHROTER PE, Steppich K, Fernandez Carrera L, Song Z, et al
    CD16(+) gammadelta T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection.
    Gut. 2026 Apr 15:gutjnl-2025-337640. doi: 10.1136/gutjnl-2025-337640.
    PubMed     Abstract available


  14. GOUTTENOIRE J, Meuleman P
    Fluorescent virus lights up on a new drug for chronic hepatitis E.
    Gut. 2026 Apr 11:gutjnl-2026-338626. doi: 10.1136/gutjnl-2026-338626.
    PubMed    


    March 2026
  15. PARLATI L, Bourliere M
    Steatosis severity and metabolic fingerprints after HCV eradication: toward an individualised approach to HCC surveillance after HCV cure.
    Gut. 2026 Mar 11:gutjnl-2026-338140. doi: 10.1136/gutjnl-2026-338140.
    PubMed    


  16. HU J, Liu T, Klohn M, Freistaedter A, et al
    Nucleotide analogue bemnifosbuvir inhibits hepatitis E virus replication in preclinical models.
    Gut. 2026 Mar 6:gutjnl-2025-336714. doi: 10.1136/gutjnl-2025-336714.
    PubMed     Abstract available


  17. WU W, Gao Q, Hai S, Li X, et al
    Impairment of Rab7-dependent STING degradation hampers HBV replication but accelerates disease progression in chronic hepatitis B comorbid with MASLD.
    Gut. 2026 Mar 3:gutjnl-2026-338065. doi: 10.1136/gutjnl-2026-338065.
    PubMed     Abstract available


  18. WENG D, Chen J, Lin C
    Absolute risk stratification of HCC after HCV cure in MASLD: do advanced steatosis and dysglycaemia add beyond liver stiffness?
    Gut. 2026 Mar 2:gutjnl-2026-338294. doi: 10.1136/gutjnl-2026-338294.
    PubMed    


    February 2026
  19. BARTOSCH B, Lauer GM
    Catch me if you can! Is there protection from HCV (re)infection?
    Gut. 2026 Feb 11:gutjnl-2025-337209. doi: 10.1136/gutjnl-2025-337209.
    PubMed    


    January 2026
  20. CORNBERG M, Lampertico P
    Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection.
    Gut. 2026 Jan 28:gutjnl-2025-337281. doi: 10.1136/gutjnl-2025-337281.
    PubMed    


  21. CHANG YP, Chen YC, Cheng PN, Fang YJ, et al
    Steatosis grade and cardiometabolic burden as determinants of hepatocellular carcinoma risk after hepatitis C cure in patients with metabolic dysfunction-associated steatotic liver disease.
    Gut. 2026 Jan 20:gutjnl-2025-337275. doi: 10.1136/gutjnl-2025-337275.
    PubMed     Abstract available


  22. LIANG X, Luo J, Zhou Q, Xin J, et al
    Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression.
    Gut. 2026;75:367-381.
    PubMed     Abstract available


    December 2025
  23. HE T, Chen M, Liu M, Zhang L, et al
    Twenty-four-week anti-PD-1 antibody regimen promoted HBsAg reduction and concurrently enhanced HBV-specific T cell responses in patients with chronic hepatitis B.
    Gut. 2025 Dec 24:gutjnl-2025-336655. doi: 10.1136/gutjnl-2025-336655.
    PubMed     Abstract available


  24. SCHWINGE D
    Hepatocyte guardian: A20 restrains ferroptosis in autoimmune hepatitis.
    Gut. 2025 Dec 24:gutjnl-2025-337347. doi: 10.1136/gutjnl-2025-337347.
    PubMed    


  25. LENS S, Burton AR, Davies J, Locatelli M, et al
    Tracking B cell immunity during perturbation of hepatitis B infection induced by treatment withdrawal.
    Gut. 2025 Dec 19:gutjnl-2024-333309. doi: 10.1136/gutjnl-2024-333309.
    PubMed     Abstract available


  26. WANG J, Zhang S, Chen Y, Fan T, et al
    Serum thrombospondin-2 as a non-invasive biomarker for liver fibrosis in chronic hepatitis B.
    Gut. 2025 Dec 17:gutjnl-2025-336665. doi: 10.1136/gutjnl-2025-336665.
    PubMed    


  27. CHU CM, Liaw YF
    Nucleos(t)ide analogue therapy for EASL immune-tolerant phase hepatitis B.
    Gut. 2025 Dec 3:gutjnl-2025-337558. doi: 10.1136/gutjnl-2025-337558.
    PubMed    


    November 2025
  28. LIN C, Huang Y, Ran N, Liu J, et al
    Therapeutic inhibition of HBsAg and HBV cccDNA through a novel phased combination treatment: glycine and interferon-alpha.
    Gut. 2025;74:2035-2049.
    PubMed     Abstract available


  29. CHEN Y, Li W, Wang S, Wang H, et al
    A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis.
    Gut. 2025 Nov 4:gutjnl-2025-336363. doi: 10.1136/gutjnl-2025-336363.
    PubMed     Abstract available


  30. KENNEDY PTF, Fung S, Buti M, Yilmaz G, et al
    Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study.
    Gut. 2025 Nov 4:gutjnl-2025-336592. doi: 10.1136/gutjnl-2025-336592.
    PubMed     Abstract available


    October 2025
  31. TANG S, Huang T, Tang R, Lin K, et al
    EASL 2025 indications revisited: phase-specific outcomes with and without nucleos(t)ide analogue therapy in chronic hepatitis B virus infection.
    Gut. 2025 Oct 28:gutjnl-2025-335449. doi: 10.1136/gutjnl-2025-335449.
    PubMed     Abstract available


  32. WANG J, Fan T, Zhu L, Zhang S, et al
    Profiles of quantitative hepatitis B surface antigen in patients with chronic hepatitis B.
    Gut. 2025 Oct 23:gutjnl-2025-336924. doi: 10.1136/gutjnl-2025-336924.
    PubMed    


  33. CHUMBE AL, van den Aardweg SMD, Boyd A, Grobben M, et al
    Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort.
    Gut. 2025 Oct 23:gutjnl-2025-336302. doi: 10.1136/gutjnl-2025-336302.
    PubMed     Abstract available


  34. LIU F, Liu T, Wu X, Yu Z, et al
    iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation.
    Gut. 2025 Oct 21:gutjnl-2025-336105. doi: 10.1136/gutjnl-2025-336105.
    PubMed     Abstract available


  35. HUANG R, Trinh HN, Yasuda S, Chau A, et al
    Differential HCC risk among HBV indeterminate types at baseline and by phase transition.
    Gut. 2025;74:1873-1882.
    PubMed     Abstract available


  36. XU X, Chen J, Yu X, Li Z, et al
    Single-cell analysis identifies RETN(+) monocyte-derived Resistin as a therapeutic target in hepatitis B virus-related acute-on-chronic liver failure.
    Gut. 2025 Oct 6:gutjnl-2025-335998. doi: 10.1136/gutjnl-2025-335998.
    PubMed     Abstract available


    September 2025
  37. TSENG TC, Yang HI, Kao JH
    Reply: Prevalence of serum HBsAg <100 IU/mL in inactive chronic hepatitis B.
    Gut. 2025 Sep 27:gutjnl-2025-336947. doi: 10.1136/gutjnl-2025-336947.
    PubMed    


  38. TSENG TC, Yang HI, Kao JH
    Reply to: 'Rethinking "inactive chronic hepatitis B": should we treat patients with high HBsAg levels?'.
    Gut. 2025 Sep 27:gutjnl-2025-336618. doi: 10.1136/gutjnl-2025-336618.
    PubMed    


    August 2025
  39. FAN T, Wang J, Zhu C, Wu C, et al
    Prevalence of serum HBsAg <100 IU/mL in inactive chronic hepatitis B.
    Gut. 2025 Aug 24:gutjnl-2025-336520. doi: 10.1136/gutjnl-2025-336520.
    PubMed    


  40. SU CW, Liang YJ, Wu JC
    Unravelling the heterogeneous HCC risk in indeterminate chronic hepatitis B.
    Gut. 2025 Aug 18:gutjnl-2025-335915. doi: 10.1136/gutjnl-2025-335915.
    PubMed    


  41. WU X, Quan D, Li W, Wisskirchen K, et al
    Clinical results of an HBV-specific T-cell receptor-T-cell therapy (SCG101) in patients with HBV-related hepatocellular carcinoma treated in an investigator-initiated, interventional trial.
    Gut. 2025 Aug 12:gutjnl-2025-335456. doi: 10.1136/gutjnl-2025-335456.
    PubMed     Abstract available


  42. HUI RW, Wu TK, Ho KC, Leung RH, et al
    Large-scale profile study on hepatitis B surface antigen levels in chronic hepatitis B: implications for drug development targeting functional cure.
    Gut. 2025 Aug 5:gutjnl-2025-335219. doi: 10.1136/gutjnl-2025-335219.
    PubMed     Abstract available


    July 2025
  43. SETO WK, Lok A
    Partial cure of chronic hepatitis B: potential implications for HCC surveillance?
    Gut. 2025 Jul 29:gutjnl-2025-336032. doi: 10.1136/gutjnl-2025-336032.
    PubMed    


  44. CHEN J, You H, Lau G
    Rethinking 'Inactive Chronic Hepatitis B': should we treat patients with high HBsAg levels?
    Gut. 2025 Jul 23:gutjnl-2025-336373. doi: 10.1136/gutjnl-2025-336373.
    PubMed    


  45. GUILLOT A, Pose E
    Hepatocyte senescence in alcohol-associated hepatitis: epiphenomenon or disease-driving mechanism?
    Gut. 2025 Jul 17:gutjnl-2025-335271. doi: 10.1136/gutjnl-2025-335271.
    PubMed    


    June 2025
  46. TSENG TC, Huang SC, Pan MH, Liu CJ, et al
    Hepatitis B surface antigen level identifies patients with inactive chronic hepatitis B from Asia with HCC risk below surveillance threshold.
    Gut. 2025 Jun 20:gutjnl-2025-334911. doi: 10.1136/gutjnl-2025-334911.
    PubMed     Abstract available


    May 2025
  47. LI H, Song M, Hylemon PB, Zhou H, et al
    LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis.
    Gut. 2025 May 13:gutjnl-2025-335259. doi: 10.1136/gutjnl-2025-335259.
    PubMed    


    April 2025
  48. ROTTELE F, Zollner A, Mogler C, Yuksel M, et al
    Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19.
    Gut. 2025 Apr 5:gutjnl-2024-333880. doi: 10.1136/gutjnl-2024-333880.
    PubMed     Abstract available


  49. LURJE I, Tacke F
    Immune pathology in paediatric acute hepatitis of unknown origin - uncovering the link to COVID-19.
    Gut. 2025 Apr 5:gutjnl-2024-334453. doi: 10.1136/gutjnl-2024-334453.
    PubMed    


  50. GLEESON D, Bornand R, Brownlee A, Dhaliwal H, et al
    British Society of Gastroenterology guidelines for diagnosis and management of autoimmune hepatitis.
    Gut. 2025 Apr 1:gutjnl-2024-333171. doi: 10.1136/gutjnl-2024-333171.
    PubMed     Abstract available


    March 2025
  51. XU H, Wu Z, Qin J, Li X, et al
    Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2.
    Gut. 2025 Mar 26:gutjnl-2024-334318. doi: 10.1136/gutjnl-2024-334318.
    PubMed     Abstract available


  52. RODRIGO-TORRES D, Kilpatrick AM, Ferreira-Gonzalez S, Aird RE, et al
    Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence.
    Gut. 2025 Mar 23:gutjnl-2024-334094. doi: 10.1136/gutjnl-2024-334094.
    PubMed     Abstract available


    December 2024
  53. LAMPERTICO P, Anolli MP, Roulot D, Wedemeyer H, et al
    Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies.
    Gut. 2024 Dec 11:gutjnl-2024-332597. doi: 10.1136/gutjnl-2024-332597.
    PubMed     Abstract available


    October 2024
  54. PAN DZ, Soulette CM, Aggarwal A, Han D, et al
    Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B.
    Gut. 2024 Oct 8:gutjnl-2024-332526. doi: 10.1136/gutjnl-2024-332526.
    PubMed     Abstract available


  55. LIU T, Li J, Yin X, Lu F, et al
    Establishment of enterically transmitted hepatitis virus animal models using lipid nanoparticle-based full-length viral genome RNA delivery system.
    Gut. 2024 Oct 1:gutjnl-2024-332784. doi: 10.1136/gutjnl-2024-332784.
    PubMed     Abstract available


    September 2024
  56. BROL MJ, Canbay A, Trebicka J
    Alcohol-associated hepatitis: a neutrophile disease?
    Gut. 2024 Sep 24:gutjnl-2024-333222. doi: 10.1136/gutjnl-2024-333222.
    PubMed    


  57. MAK LY, Wooddell CI, Lenz O, Schluep T, et al
    Long-term hepatitis B surface antigen response after finite treatment of ARC-520 or JNJ-3989.
    Gut. 2024 Sep 12:gutjnl-2024-333026. doi: 10.1136/gutjnl-2024-333026.
    PubMed     Abstract available


  58. FAN R, Zhao S, Niu J, Ma H, et al
    High accuracy model for HBsAg loss based on longitudinal trajectories of serum qHBsAg throughout long-term antiviral therapy.
    Gut. 2024;73:1725-1736.
    PubMed     Abstract available


    July 2024
  59. VECCHI A, Rossi M, Tiezzi C, Fisicaro P, et al
    HBcrAg values may predict virological and immunological responses to pegIFN-alpha in NUC-suppressed HBeAg-negative chronic hepatitis B.
    Gut. 2024 Jul 20:gutjnl-2024-332290. doi: 10.1136/gutjnl-2024-332290.
    PubMed     Abstract available


  60. KREIMEYER H, Gonzalez CG, Fondevila MF, Hsu CL, et al
    Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis.
    Gut. 2024 Jul 20:gutjnl-2024-332730. doi: 10.1136/gutjnl-2024-332730.
    PubMed     Abstract available


  61. BAUMERT T, Urbanek-Quaing M, Cornberg M
    Immunomodulation and entry inhibition: selgantolimod's double punch against hepatitis B virus.
    Gut. 2024 Jul 5:gutjnl-2024-332679. doi: 10.1136/gutjnl-2024-332679.
    PubMed    


  62. KAMAR N, Marion O, Abravanel F, Esposito L, et al
    Porcine-derived pancreatic enzyme replacement therapy: a cause of hepatitis E virus transmission?
    Gut. 2024 Jul 2:gutjnl-2024-332744. doi: 10.1136/gutjnl-2024-332744.
    PubMed    


    June 2024
  63. ZHOU J, Liu K, Pan Q
    Porcine-derived pancreatic enzyme replacement therapy linking to chronic hepatitis E: broad implications.
    Gut. 2024 Jun 12:gutjnl-2024-332975. doi: 10.1136/gutjnl-2024-332975.
    PubMed    


    May 2024
  64. FRERICKS N, Kinast V, Steinmann E
    Potential risk of porcine-derived pancreatic enzyme medication for the cross-species transmission of hepatitis E virus.
    Gut. 2024 May 31:gutjnl-2024-332577. doi: 10.1136/gutjnl-2024-332577.
    PubMed    


  65. VO-QUANG E, Pawlotsky JM
    'Unusual' HCV genotype subtypes: origin, distribution, sensitivity to direct-acting antiviral drugs and behaviour on antiviral treatment and retreatment.
    Gut. 2024 May 23:gutjnl-2024-332177. doi: 10.1136/gutjnl-2024-332177.
    PubMed     Abstract available


  66. ROCA SUAREZ AA, Plissonnier ML, Grand X, Michelet M, et al
    TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.
    Gut. 2024 May 2:gutjnl-2023-331396. doi: 10.1136/gutjnl-2023-331396.
    PubMed     Abstract available


    April 2024
  67. THORNTON CS, Waddell BJ, Congly SE, Svishchuk J, et al
    Porcine-derived pancreatic enzyme replacement therapy may be linked to chronic hepatitis E virus infection in cystic fibrosis lung transplant recipients.
    Gut. 2024 Apr 15:gutjnl-2023-330602. doi: 10.1136/gutjnl-2023-330602.
    PubMed     Abstract available


    January 2024
  68. HE T, Zhang D
    Non-linear association of baseline viral load with on-treatment hepatocellular carcinoma risk in chronic hepatitis B: still needs further discussion.
    Gut. 2024 Jan 22:gutjnl-2023-331443. doi: 10.1136/gutjnl-2023-331443.
    PubMed    



  69. Correction: Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies.
    Gut. 2024;73:e1.
    PubMed    


  70. LIN C, Luo L, Xun Z, Zhu C, et al
    Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection.
    Gut. 2024;73:338-349.
    PubMed     Abstract available


    November 2023
  71. WANG Y, Li Q, Li C, Wang C, et al
    Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion.
    Gut. 2023 Nov 16:gutjnl-2023-330537. doi: 10.1136/gutjnl-2023-330537.
    PubMed     Abstract available


  72. YU X, Gong Q, Yu D, Chen Y, et al
    Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss.
    Gut. 2023 Nov 15:gutjnl-2023-330577. doi: 10.1136/gutjnl-2023-330577.
    PubMed     Abstract available


    October 2023
  73. TESTONI B, Scholtes C, Plissonnier ML, Paturel A, et al
    Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B.
    Gut. 2023 Oct 25:gutjnl-2023-330644. doi: 10.1136/gutjnl-2023-330644.
    PubMed     Abstract available


  74. CHOI WM, Kim GA, Choi J, Choi GH, et al
    Non-linear association of baseline viral load with on-treatment hepatocellular carcinoma risk in chronic hepatitis B.
    Gut. 2023 Oct 9:gutjnl-2023-330225. doi: 10.1136/gutjnl-2023-330225.
    PubMed     Abstract available


  75. LIU Z, Lin C, Mao X, Guo C, et al
    Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people.
    Gut. 2023 Oct 5:gutjnl-2023-330691. doi: 10.1136/gutjnl-2023-330691.
    PubMed     Abstract available


    September 2023
  76. LE BERT N, Fisicaro P
    Enolase: a metabolic checkpoint behind diverse exhaustion stages of CD8+ T cells in chronic HBV and HCV.
    Gut. 2023 Sep 6:gutjnl-2023-330541. doi: 10.1136/gutjnl-2023-330541.
    PubMed    


    January 2023
  77. HENDRIKX T, Lang S, Rajcic D, Wang Y, et al
    Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
    Gut. 2023 Jan 23:gutjnl-2022-328265. doi: 10.1136/gutjnl-2022-328265.
    PubMed     Abstract available


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