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Articles published in J Clin Invest

Retrieve available abstracts of 51 articles:
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Single Articles


    October 2026
  1. JAMIL R, Huibner S, Yang P, Nnamutete J, et al
    Impact of sexual debut on urethral immunology and microbiome in adolescent males from Rakai, Uganda.
    J Clin Invest. 2026 Oct 6:e208629. doi: 10.1172/JCI208629.
    PubMed     Abstract available


    August 2026
  2. JALALI S, Natesampillai S, Nie Z, Zhang Y, et al
    TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo.
    J Clin Invest. 2026;136:e194449.
    PubMed     Abstract available


    July 2026
  3. MOYSI E, Sharma AA, O'Dell S, Georgakis S, et al
    A favorable follicular helper CD4 T cell programming characterizes neutralization activity in chronic HIV infection.
    J Clin Invest. 2026 Jul 14:e192575. doi: 10.1172/JCI192575.
    PubMed     Abstract available


    June 2026
  4. HOTCHKISS RS, Monneret G
    Host-directed immune therapies: a second front in the battle against sepsis.
    J Clin Invest. 2026;136:e204736.
    PubMed     Abstract available


    May 2026
  5. GAY CL, Xu Y, Weideman AMK, Shaw FR, et al
    MVA.tHIVconsvX vaccination-evoked T cell expansion inversely associates with age in people with HIV-1 on antiretroviral therapy.
    J Clin Invest. 2026 May 5:e193547. doi: 10.1172/JCI193547.
    PubMed     Abstract available


  6. NIDEFFER J, Bach F, Strubbe S, Lopez L, et al
    CXCR6+CD127- Tr1 cells balance immunity and persistence in Plasmodium falciparum infection.
    J Clin Invest. 2026 May 5:e200628. doi: 10.1172/JCI200628.
    PubMed     Abstract available


  7. FILIPPIDIS P, Farhadian SF
    Smoldering in the sanctuary: HIV-associated brain injury in the ART era.
    J Clin Invest. 2026;136:e204831.
    PubMed     Abstract available


    April 2026
  8. CASCINO K, Liechti T, Seaberg EC, Stevens KE, et al
    HIV causes global B-cell dysregulation and restricts HBV-specific B-cell development in an incident HBV cohort.
    J Clin Invest. 2026 Apr 7:e203138. doi: 10.1172/JCI203138.
    PubMed     Abstract available


  9. MASSANELLA M, Dufour C, Pagliuzza A, Lemieux A, et al
    Rapid and profound decay of inducible and intact HIV genomes in early treated Thai children.
    J Clin Invest. 2026 Apr 2:e198054. doi: 10.1172/JCI198054.
    PubMed     Abstract available


    March 2026
  10. PACHE L, Bui JK, Klouser LM, Fennessey CM, et al
    Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques.
    J Clin Invest. 2026;136:e187961.
    PubMed     Abstract available


    February 2026
  11. PAL PB, Elizaldi SR, Diniz GB, Rai RP, et al
    alpha4 integrin blockade impairs CD8 T cell neuroimmune surveillance following SIV infection.
    J Clin Invest. 2026 Feb 24:e198730. doi: 10.1172/JCI198730.
    PubMed     Abstract available


  12. BLAZKOVA J, Kennedy BD, Justement JS, Shi V, et al
    Characterization of elite controllers with undetectable intact HIV DNA reservoir.
    J Clin Invest. 2026 Feb 17:e202577. doi: 10.1172/JCI202577.
    PubMed    


  13. NIESAR A, Lancien M, Hong S, Naasz C, et al
    Immune correlates of HIV-1 rebound during broadly neutralizing antibody treatment in young children.
    J Clin Invest. 2026;136:e193912.
    PubMed     Abstract available


  14. ELWY A, Abdelrahman H, Specht J, Ewert GM, et al
    Type I IFN-dependent FcgammaRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections.
    J Clin Invest. 2026;136:e192371.
    PubMed     Abstract available


  15. KIOKO M, Mwangi S, Fwambah L, Hassan AS, et al
    Variation in antiviral immunity and inflammation pathways precedes HIV-1 infection in a high-risk African cohort.
    J Clin Invest. 2026 Feb 12:e195172. doi: 10.1172/JCI195172.
    PubMed     Abstract available


    January 2026
  16. OMANGE WR, Varco-Merth BD, Fadeyi O, Marenco A, et al
    Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound.
    J Clin Invest. 2026 Jan 29:e198294. doi: 10.1172/JCI198294.
    PubMed     Abstract available


    December 2025
  17. PETERSON JJ, Chandel S, James K, Bennett ES, et al
    Single cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes.
    J Clin Invest. 2025 Dec 23:e196536. doi: 10.1172/JCI196536.
    PubMed     Abstract available


  18. ABELMAN RA, Schnittman SR, Faraj Murad N, Olshen A, et al
    Age modifies the association between sex and the plasma inflammatory proteome in treated HIV.
    J Clin Invest. 2025 Dec 9:e196869. doi: 10.1172/JCI196869.
    PubMed     Abstract available


    November 2025
  19. DONALDSON A, Druker MR, Monaco MC, Stack EH, et al
    Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells.
    J Clin Invest. 2025 Nov 25:e195764. doi: 10.1172/JCI195764.
    PubMed     Abstract available


    October 2025
  20. DRAGONI F, Sop J, Gurumurthy I, Beckey TP, et al
    Selective targeting of HIV infected clones by cognate peptide stimulation and antiproliferative drugs.
    J Clin Invest. 2025 Oct 21:e197266. doi: 10.1172/JCI197266.
    PubMed     Abstract available


  21. ARCHIN NM
    A die is cast: autologous neutralizing antibody resistance shapes the HIV reservoir during uninterrupted ART.
    J Clin Invest. 2025;135:e198353.
    PubMed     Abstract available


    September 2025
  22. KOLOSSVARY M, Sereti I, Zanni MV, Fichtenbaum CJ, et al
    Statin-dependent and -independent pathways are associated with major adverse cardiovascular events in people with HIV.
    J Clin Invest. 2025 Sep 9:e196021. doi: 10.1172/JCI196021.
    PubMed     Abstract available


    August 2025
  23. OMOLE TE, McKinnon LR
    Integrin alpha4beta7 as a predictor of HIV acquisition: one thread in a complex tapestry.
    J Clin Invest. 2025;135:e195258.
    PubMed     Abstract available


    July 2025
  24. MCMYN NF, Varriale J, Wu HWS, Hariharan V, et al
    Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies.
    J Clin Invest. 2025 Jul 29:e194081. doi: 10.1172/JCI194081.
    PubMed     Abstract available


  25. JASINSKA AJ, Sivanandham R, Sivanandham S, Xu C, et al
    Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques.
    J Clin Invest. 2025;135:e189574.
    PubMed     Abstract available


    June 2025
  26. RAMASWAMY S, Akiyama H, Berrigan J, Quinones-Molina AA, et al
    The macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses.
    J Clin Invest. 2025 Jun 10:e187663. doi: 10.1172/JCI187663.
    PubMed     Abstract available


  27. DESAI SS, Salahuddin S, Yusuf R, Ranjan K, et al
    Tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV.
    J Clin Invest. 2025 Jun 3:e177310. doi: 10.1172/JCI177310.
    PubMed     Abstract available


    May 2025
  28. MACHMACH K, N'guessan KF, Farmer R, Godbole S, et al
    NK cell activation and CD4 T cell alpha4beta7 expression are associated with susceptibility to HIV-1.
    J Clin Invest. 2025 May 8:e187992. doi: 10.1172/JCI187992.
    PubMed     Abstract available


    April 2025
  29. IMAMICHI H, Natarajan V, Scrimieri F, Smith M, et al
    Widespread distribution of transcriptionally active, clonally expanded, HIV-1 proviruses despite suppressive antiretroviral therapy.
    J Clin Invest. 2025 Apr 22:e190824. doi: 10.1172/JCI190824.
    PubMed     Abstract available


  30. PAL PB, Iyer SS
    Transient pain and long-term gain: adjuvant dose directs immune memory.
    J Clin Invest. 2025;135:e190524.
    PubMed     Abstract available


  31. VIOLARI A, Otwombe K, Hahn W, Chen S, et al
    Safety and implementation of phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns.
    J Clin Invest. 2025 Apr 3:e186927. doi: 10.1172/JCI186927.
    PubMed     Abstract available


  32. SETIABUDIAWAN TP, Hill PC, DiNardo AR, van Crevel R, et al
    Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?
    J Clin Invest. 2025;135:e191423.
    PubMed     Abstract available


    March 2025
  33. MACLEAN F, Tsegaye AT, Graham JB, Swarts JL, et al
    Bacterial vaginosis associates with dysfunctional T cells and altered soluble immune factors in the cervicovaginal tract.
    J Clin Invest. 2025 Mar 25:e184609. doi: 10.1172/JCI184609.
    PubMed     Abstract available


  34. KATUSIIME MG, Neer V, Guo S, Patro SC, et al
    Divergent populations of HIV-infected naive and memory CD4+ T-cell clones in children on antiretroviral therapy.
    J Clin Invest. 2025 Mar 6:e188533. doi: 10.1172/JCI188533.
    PubMed     Abstract available


  35. RAMEZANI-RAD P, Marina-Zarate E, Maiorino L, Myers A, et al
    The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in non-human primates.
    J Clin Invest. 2025 Mar 4:e185292. doi: 10.1172/JCI185292.
    PubMed     Abstract available


    February 2025
  36. MU W, Tomer S, Harding J, Kedia N, et al
    Rapamycin Enhances CAR-T Control of HIV Replication and Reservoir Elimination in vivo.
    J Clin Invest. 2025 Feb 11:e185489. doi: 10.1172/JCI185489.
    PubMed     Abstract available


    January 2025
  37. TADDESE M, Grudda T, Belluccini G, Anderson M, et al
    Transcription of hepatitis B surface antigen shifts from cccDNA to integrated HBV DNA during treatment.
    J Clin Invest. 2025 Jan 30:e184243. doi: 10.1172/JCI184243.
    PubMed     Abstract available


  38. DALLMANN-SAUER M, Fava VM, Malherbe ST, MacDonald CE, et al
    Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli.
    J Clin Invest. 2025 Jan 21:e188016. doi: 10.1172/JCI188016.
    PubMed     Abstract available


    December 2024
  39. LEE MJ, Yeon JH, Lee J, Kang YH, et al
    Senescence of endothelial cells increases susceptibility to Kaposi's sarcoma-associated herpesvirus infection via CD109-mediated viral entry.
    J Clin Invest. 2024 Dec 12:e183561. doi: 10.1172/JCI183561.
    PubMed     Abstract available


    November 2024
  40. GONZALEZ-NAVARRO I, Urrea V, Galvez C, Garcia-Guerrero MDC, et al
    Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir.
    J Clin Invest. 2024 Nov 29:e183952. doi: 10.1172/JCI183952.
    PubMed     Abstract available


    October 2024
  41. DURAND CM, Redd AD
    HOPE springs eternal: lack of HIV superinfection in HIV Organ Policy Equity Act kidney transplants.
    J Clin Invest. 2024;134:e184326.
    PubMed     Abstract available


  42. MANNING MR, Blazkova J, Justement JS, Shi V, et al
    Timing of antiretroviral therapy initiation affects intact HIV reservoirs following analytical treatment interruption.
    J Clin Invest. 2024;134:e181632.
    PubMed    


  43. KINCER LP, Dravid A, Trunfio M, Calcagno A, et al
    Neurosymptomatic HIV-1 CSF escape is associated with replication in CNS T cells and inflammation.
    J Clin Invest. 2024;134:e176358.
    PubMed     Abstract available


    September 2024
  44. MIHEALSICK E, Word A, Scully EP
    The impact of sex on HIV immunopathogenesis and therapeutic interventions.
    J Clin Invest. 2024;134:e180075.
    PubMed     Abstract available


  45. TRAVIESO T, Stadtler H, Alavian N, Gao F, et al
    Longitudinal analysis of viral dynamics in HIV+ to HIV+ HOPE Act kidney-transplant recipients.
    J Clin Invest. 2024 Sep 10:e181560. doi: 10.1172/JCI181560.
    PubMed     Abstract available


    July 2024
  46. KLOTMAN ME, Haynes BF
    The other pandemic: lessons from 40 years of HIV research.
    J Clin Invest. 2024;134:e183039.
    PubMed    


    June 2024
  47. JOY J, Gervassi AL, Chen L, Kirshenbaum B, et al
    Antigen specificities and proviral integration sites differ in HIV-infected cells by timing of antiretroviral treatment initiation.
    J Clin Invest. 2024 Jun 4:e159569. doi: 10.1172/JCI159569.
    PubMed     Abstract available


    May 2024
  48. TEBAS P, Jadlowsky JK, Shaw PA, Tian L, et al
    CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication.
    J Clin Invest. 2024;134:e181576.
    PubMed    


    April 2024
  49. WHITEHILL GD, Joy J, Marino FE, Krause RJ, et al
    Autologous neutralizing antibody responses after antiretroviral therapy in acute and early HIV-1.
    J Clin Invest. 2024 Apr 23:e176673. doi: 10.1172/JCI176673.
    PubMed     Abstract available


  50. EICHHOLZ K, Fukazawa Y, Peterson CW, Haeseleer F, et al
    Anti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers.
    J Clin Invest. 2024;134:e169309.
    PubMed     Abstract available


    March 2024
  51. ELIZALDI SR, Hawes CE, Verma A, Shaan Lakshmanappa Y, et al
    Chronic SIV-induced neuroinflammation disrupts CCR7+CD4+ T cell immunosurveillance in the rhesus macaque brain.
    J Clin Invest. 2024 Mar 12:e175332. doi: 10.1172/JCI175332.
    PubMed     Abstract available


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