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2049 Chinese

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By B. S. Kamps et al.


  Head and Neck Cancer

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Articles published in Clin Cancer Res

Retrieve available abstracts of 130 articles:
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Single Articles


    March 2024
  1. SWIECICKI PL, Bellile E, Dragovic AF, McHugh J, et al
    Upfront neck dissection for treatment selection and improvement in quality of life as a novel treatment paradigm for deintensification in HPV+ OPSCC.
    Clin Cancer Res. 2024 Mar 22. doi: 10.1158/1078-0432.CCR-23-3247.
    PubMed     Abstract available


  2. KIM CG, Hong MH, Kim D, Lee BH, et al
    A phase II open-label randomized clinical trial of preoperative durvalumab or durvalumab plus tremelimumab in resectable head and neck squamous cell carcinoma.
    Clin Cancer Res. 2024 Mar 8. doi: 10.1158/1078-0432.CCR-23-3249.
    PubMed     Abstract available


  3. JAKOBSEN K, Carlander AF, Todsen T, Melchiors J, et al
    Mesenchymal Stem/Stromal Cell Therapy for Radiation-Induced Xerostomia in Previous Head and Neck Cancer Patients: A Phase 2 Randomised, Placebo-Controlled Trial.
    Clin Cancer Res. 2024 Mar 5. doi: 10.1158/1078-0432.CCR-23-3675.
    PubMed     Abstract available


    February 2024
  4. SAITO S, Kono M, Nguyen HCB, Egloff AM, et al
    Targeting Dendritic Cell Dysfunction to Circumvent anti-PD1 Resistance in Head and Neck Cancer.
    Clin Cancer Res. 2024 Feb 19. doi: 10.1158/1078-0432.CCR-23-3477.
    PubMed     Abstract available


    January 2024
  5. MEHANNA H, Rapozo D, von Zeidler SV, Harrington KJ, et al
    Developing and Validating a Multivariable Prognostic-Predictive Classifier for Treatment Escalation of Oropharyngeal Squamous Cell Carcinoma: The PREDICTR-OPC Study.
    Clin Cancer Res. 2024;30:356-367.
    PubMed     Abstract available


  6. VON WITZLEBEN A, Ellis M, Thomas GJ, Hoffmann TK, et al
    Tumor-Infiltrating CD103+ Tissue-Resident Memory T Cells and CD103-CD8+ T Cells in HNSCC Are Linked to Outcome in Primary but not Metastatic Disease.
    Clin Cancer Res. 2024;30:224-234.
    PubMed     Abstract available


  7. PENA-OYARZUN D, Flores T, Torres VA, Quest AFG, et al
    Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis.
    Clin Cancer Res. 2024;30:209-223.
    PubMed     Abstract available


    December 2023
  8. KIM YH, Yoon SJ, Kim M, Kim HH, et al
    Integrative multi-omics analysis reveals different metabolic phenotypes based on molecular characteristics in thyroid cancer.
    Clin Cancer Res. 2023 Dec 13. doi: 10.1158/1078-0432.CCR-23-2025.
    PubMed     Abstract available


    November 2023
  9. NGAMPHAIBOON N, Pattaranutaporn P, Lukerak S, Siripoon T, et al
    A Phase I Study of the CDK4/6 Inhibitor, Palbociclib in Combination with Cetuximab and Radiotherapy (IMRT) for Locally Advanced Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2023 Nov 20. doi: 10.1158/1078-0432.CCR-23-2303.
    PubMed     Abstract available


  10. OU X, Zhai R, Wei W, Chen J, et al
    Induction Toripalimab And Chemotherapy For Organ Preservation In Locally Advanced Laryngeal And Hypopharyngeal Cancer: A Single-Arm Phase 2 Clinical Trial.
    Clin Cancer Res. 2023 Nov 13. doi: 10.1158/1078-0432.CCR-23-2398.
    PubMed     Abstract available


  11. SHEN C, Shi X, Wen D, Zhang Y, et al
    Comprehensive DNA Methylation Profiling of Medullary Thyroid Carcinoma: Molecular Classification, Potential Therapeutic Target, and Classifier System.
    Clin Cancer Res. 2023 Nov 6. doi: 10.1158/1078-0432.CCR-23-2142.
    PubMed     Abstract available


    October 2023
  12. PIFER PM, Yang L, Kumar M, Xie T, et al
    FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.
    Clin Cancer Res. 2023 Oct 11. doi: 10.1158/1078-0432.CCR-23-0964.
    PubMed     Abstract available


  13. FU H, Huang J, Zhao T, Wang H, et al
    Fibroblast Activation Protein-Targeted Radioligand Therapy with 177Lu-EB-FAPI for Metastatic Radioiodine Refractory Thyroid Cancer: First-in-Human, Dose-Escalation Study.
    Clin Cancer Res. 2023 Oct 6. doi: 10.1158/1078-0432.CCR-23-1983.
    PubMed     Abstract available


  14. KLEMPNER SJ, Lee KW, Shitara K, Metges JP, et al
    ILUSTRO: Phase II Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma.
    Clin Cancer Res. 2023;29:3882-3891.
    PubMed     Abstract available


  15. JAKOBSEN KK, Bendtsen SK, Pallisgaard N, Friborg J, et al
    Liquid Biopsies with Circulating Plasma HPV-DNA Measurements-A Clinically Applicable Surveillance Tool for Patients with HPV-Positive Oropharyngeal Cancer.
    Clin Cancer Res. 2023;29:3914-3923.
    PubMed     Abstract available


    September 2023
  16. DERRY JMJ, Burns C, Frazier JP, Beirne E, et al
    Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.
    Clin Cancer Res. 2023;29:3813-3825.
    PubMed     Abstract available


  17. DUKE ES, Bradford D, Marcovitz M, Amatya AK, et al
    FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
    Clin Cancer Res. 2023;29:3573-3578.
    PubMed     Abstract available


  18. LEE MS, Kaseb AO, Pant S
    The Emerging Role of Circulating Tumor DNA in Non-Colorectal Gastrointestinal Cancers.
    Clin Cancer Res. 2023;29:3267-3274.
    PubMed     Abstract available


    August 2023
  19. CHI Y, Zheng X, Zhang Y, Shi F, et al
    Anlotinib in Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma: A Randomized, Double-Blind, Multicenter Phase â…¡ Trial.
    Clin Cancer Res. 2023 Aug 18:CCR-22-3406. doi: 10.1158/1078-0432.CCR-22-3406.
    PubMed     Abstract available


  20. HEFT NEAL ME, Brenner JC
    Prognosis to Radiation Unlocked: How Hypoxia Methylome May Hold the Key in HNSCC.
    Clin Cancer Res. 2023;29:2954-2956.
    PubMed     Abstract available


  21. TAWK B, Rein K, Schwager C, Knoll M, et al
    DNA-Methylome-Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy.
    Clin Cancer Res. 2023;29:3051-3064.
    PubMed     Abstract available


  22. NIU Z, Sun P, Liu H, Wei P, et al
    Functional Genetic Variants in TGFbeta1 and TGFbetaR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma.
    Clin Cancer Res. 2023;29:3081-3091.
    PubMed     Abstract available


  23. JACOBS MT, Wong P, Zhou AY, Becker-Hapak M, et al
    Memory-like differentiation, tumor targeting monoclonal antibodies, and chimeric antigen receptors enhance natural killer cell responses to head and neck cancer.
    Clin Cancer Res. 2023 Aug 9:CCR-23-0156. doi: 10.1158/1078-0432.CCR-23-0156.
    PubMed     Abstract available


  24. BEYAERT SP, Loriot AE, Huyghe ND, Goebbels RM, et al
    Tumor microenvironment modifications induced by afatinib in squamous cell carcinoma of the head and neck - a window-of-opportunity study (EORTC90111-24111).
    Clin Cancer Res. 2023 Aug 2:CCR-23-0645. doi: 10.1158/1078-0432.CCR-23-0645.
    PubMed     Abstract available


    July 2023
  25. MORI K, Notsu A, Miura K, Onozawa Y, et al
    MEDI0457 Plus Durvalumab in HPV-associated HNSCC-Letter.
    Clin Cancer Res. 2023;29:2735.
    PubMed    


  26. AGGARWAL C, Gong M, Kumar R
    MEDI0457 Plus Durvalumab in HPV-associated HNSCC-Response.
    Clin Cancer Res. 2023;29:2736.
    PubMed    


  27. MARON SB, Chatila W, Walch H, Chou JF, et al
    Determinants of survival in HER2+ metastatic esophagogastric cancer.
    Clin Cancer Res. 2023 Jul 5:CCR-22-3769. doi: 10.1158/1078-0432.CCR-22-3769.
    PubMed     Abstract available


  28. HONDERMARCK H, Jiang CC
    Time to Introduce Nerve Density in Cancer Histopathologic Assessment.
    Clin Cancer Res. 2023;29:2342-2344.
    PubMed     Abstract available


    June 2023
  29. SHER DJ, Moon DH, Vo D, Wang J, et al
    Efficacy and quality-of-life following involved nodal radiotherapy for head and neck squamous cell carcinoma: the INRT-AIR phase II clinical trial.
    Clin Cancer Res. 2023 Jun 26:CCR-23-0334. doi: 10.1158/1078-0432.CCR-23-0334.
    PubMed     Abstract available


  30. HU H, Ng TSC, Kang M, Scott E, et al
    Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response.
    Clin Cancer Res. 2023 Jun 8:CCR-22-2976. doi: 10.1158/1078-0432.CCR-22-2976.
    PubMed     Abstract available


  31. BIKAS A, Ahmadi S, Pappa T, Marqusee E, et al
    Additional Oncogenic Alterations in RAS-Driven Differentiated Thyroid Cancers Associate with Worse Clinicopathologic Outcomes.
    Clin Cancer Res. 2023 Jun 1:OF1-OF8. doi: 10.1158/1078-0432.CCR-23-0278.
    PubMed     Abstract available


    May 2023
  32. LIN Y, Qin S, Yang H, Shi F, et al
    Multicenter randomized double-blind phase III trial of donafenib in progressive radioactive iodine-refractory differentiated thyroid cancer.
    Clin Cancer Res. 2023 May 15:CCR-22-3613. doi: 10.1158/1078-0432.CCR-22-3613.
    PubMed     Abstract available


    April 2023
  33. LEBOULLEUX S, Do Cao C, Zerdoud S, Attard M, et al
    A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E Mutated Differentiated thyroid Cancer.
    Clin Cancer Res. 2023 Apr 19:CCR-23-0046. doi: 10.1158/1078-0432.CCR-23-0046.
    PubMed     Abstract available


  34. PEREZ-PACHECO C, Schmitd LB, Furgal A, Bellile EL, et al
    Increased Nerve Density Adversely Affects Outcome in Oral Cancer.
    Clin Cancer Res. 2023 Apr 11:OF1-OF12. doi: 10.1158/1078-0432.CCR-22-3496.
    PubMed     Abstract available


    February 2023
  35. GULATI S, Crist M, Riaz MK, Takiar V, et al
    Durvalumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, non-randomized, phase-2 clinical trial.
    Clin Cancer Res. 2023 Feb 21:CCR-22-3886. doi: 10.1158/1078-0432.CCR-22-3886.
    PubMed     Abstract available


  36. WILDSMITH S, Li W, Wu S, Stewart R, et al
    Tumor Mutational Burden as a Predictor of Survival With Durvalumab and/or Tremelimumab Treatment in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2023 Feb 20:CCR-22-2765. doi: 10.1158/1078-0432.CCR-22-2765.
    PubMed     Abstract available


  37. BOUCAI L, Saqcena M, Kuo F, Grewal RK, et al
    Genomic and transcriptomic characteristics of metastatic thyroid cancers with exceptional responses to radioactive iodine therapy.
    Clin Cancer Res. 2023 Feb 13:CCR-22-2882. doi: 10.1158/1078-0432.CCR-22-2882.
    PubMed     Abstract available


  38. WILS LJ, Poell JB, Brink A, Evren I, et al
    Elucidating the Genetic Landscape of Oral Leukoplakia to Predict Malignant Transformation.
    Clin Cancer Res. 2023;29:602-613.
    PubMed     Abstract available


  39. GE H, Ferris RL, Wang JH
    Cetuximab Responses in Patients with HNSCC Correlate to Clonal Expansion Feature of Peripheral and Tumor-Infiltrating T Cells with Top T-Cell Receptor Clonotypes.
    Clin Cancer Res. 2023;29:647-658.
    PubMed     Abstract available


    January 2023
  40. OSMAN AA, Arslan E, Bartels M, Michikawa C, et al
    Dysregulation and epigenetic reprogramming of NRF2 signaling axis promote acquisition of cisplatin resistance and metastasis in Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2023 Jan 23:CCR-22-2747. doi: 10.1158/1078-0432.CCR-22-2747.
    PubMed     Abstract available


  41. MASCARELLA MA, Olonisakin TF, Rumde P, Vendra V, et al
    Response to neoadjuvant targeted therapy in operable head and neck cancer confers survival benefit.
    Clin Cancer Res. 2023 Jan 3:CCR-22-1768. doi: 10.1158/1078-0432.CCR-22-1768.
    PubMed     Abstract available


    December 2022
  42. HORIBA MN, Casak SJ, Mishra-Kalyani PS, Roy P, et al
    FDA Approval Summary: Nivolumab for the Adjuvant Treatment of Adults with Completely Resected Esophageal/Gastroesophageal Junction Cancer and Residual Pathologic Disease.
    Clin Cancer Res. 2022;28:5244-5248.
    PubMed     Abstract available


  43. MEZGHANI N, Yao A, Vasilyeva D, Kaplan N, et al
    Molecular Subtypes of Head and Neck Cancer in Patients of African Ancestry.
    Clin Cancer Res. 2022 Dec 12:CCR-22-2258. doi: 10.1158/1078-0432.CCR-22-2258.
    PubMed     Abstract available


  44. AGGARWAL C, Saba NF, Algazi A, Sukari A, et al
    Safety and Efficacy of MEDI0457 Plus Durvalumab in Patients With Human Papillomavirus-associated Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2022 Dec 1:CCR-22-1987. doi: 10.1158/1078-0432.CCR-22-1987.
    PubMed     Abstract available


  45. NATHAN CO, Hayes DN, Karrison T, Harismendy O, et al
    A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck.
    Clin Cancer Res. 2022;28:5040-5048.
    PubMed     Abstract available


  46. SHI W, Fijardo M, Bruce JP, Su J, et al
    CD8+ Tumor-Infiltrating Lymphocyte Abundance Is a Positive Prognostic Indicator in Nasopharyngeal Cancer.
    Clin Cancer Res. 2022;28:5202-5210.
    PubMed     Abstract available


    November 2022
  47. RODRIGUEZ-RAMIREZ C, Zhang Z, Warner KA, Herzog AE, et al
    p53 Inhibits Bmi-1-driven Self-Renewal and Defines Salivary Gland Cancer Stemness.
    Clin Cancer Res. 2022;28:4757-4770.
    PubMed     Abstract available


  48. FERGUSON AL, Sharman AR, Allen RO, Ye T, et al
    High-Dimensional and Spatial Analysis Reveals Immune Landscape-Dependent Progression in Cutaneous Squamous Cell Carcinoma.
    Clin Cancer Res. 2022;28:4677-4688.
    PubMed     Abstract available


    October 2022
  49. CABANILLAS ME, Busaidy NL, Sherman SI
    Redifferentiation Therapy-Returning to Our Roots in a Post-Kinase Inhibitor World.
    Clin Cancer Res. 2022;28:4164-4166.
    PubMed     Abstract available


  50. COLEVAS AD
    HPV DNA as a Biomarker in Oropharyngeal Cancer: A Step in the Right Direction.
    Clin Cancer Res. 2022;28:4171-4172.
    PubMed     Abstract available


  51. BERGER BM, Hanna GJ, Posner MR, Genden EM, et al
    Detection of Occult Recurrence Using Circulating Tumor Tissue Modified Viral HPV DNA among Patients Treated for HPV-Driven Oropharyngeal Carcinoma.
    Clin Cancer Res. 2022;28:4292-4301.
    PubMed     Abstract available


    September 2022
  52. PAUDEL S, Warner BE, Wang R, Adams-Haduch J, et al
    Serological profiling using an Epstein-Barr virus mammalian expression library identifies EBNA1 IgA as a pre-diagnostic marker for nasopharyngeal carcinoma.
    Clin Cancer Res. 2022 Sep 27. pii: 709488. doi: 10.1158/1078-0432.CCR-22-1600.
    PubMed     Abstract available


  53. MIERZWA ML, Aryal M, Lee C, Schipper M, et al
    Randomized Phase II study of Physiologic MRI-directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer.
    Clin Cancer Res. 2022 Sep 15. pii: 709219. doi: 10.1158/1078-0432.CCR-22-1522.
    PubMed     Abstract available


  54. YU M, Moinova HR, Willbanks A, Cannon VK, et al
    Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia.
    Clin Cancer Res. 2022;28:3761-3769.
    PubMed     Abstract available


  55. ROHRER BLEY C, Wolf F, Goncalves Jorge P, Grilj V, et al
    Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs.
    Clin Cancer Res. 2022;28:3814-3823.
    PubMed     Abstract available


    August 2022
  56. QURESHY Z, Li H, Zeng Y, Rivera J, et al
    STAT3 activation as a predictive biomarker for ruxolitinib response in head and neck cancer.
    Clin Cancer Res. 2022 Aug 5. pii: 707467. doi: 10.1158/1078-0432.CCR-22-0744.
    PubMed     Abstract available


  57. LEE YJ, van den Berg NS, Duan H, Azevedo EC, et al
    89Zr-panitumumab combined with 18F-FDG-PET improves detection and staging of head and neck squamous cell carcinoma.
    Clin Cancer Res. 2022 Aug 5. pii: 707464. doi: 10.1158/1078-0432.CCR-22-0094.
    PubMed     Abstract available


  58. YOON HH, Dong H, Shi Q
    Impact of PD-1 Blockade in Nonresponders: Pitfalls and Promise.
    Clin Cancer Res. 2022;28:3173-3175.
    PubMed     Abstract available


  59. HONG X, Li Q, Li J, Chen K, et al
    CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization.
    Clin Cancer Res. 2022 Aug 2. pii: 707414. doi: 10.1158/1078-0432.CCR-22-0991.
    PubMed     Abstract available


    July 2022
  60. ZHU M, Chen C, Foster NR, Hartley C, et al
    Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction.
    Clin Cancer Res. 2022;28:3021-3031.
    PubMed     Abstract available


  61. JUNG HA, Park KU, Cho S, Lim J, et al
    A Phase II Study of Nivolumab Plus Gemcitabine in Patients with Recurrent or Metastatic Nasopharyngeal Carcinoma (KCSG HN17-11).
    Clin Cancer Res. 2022 Jul 12. pii: 706988. doi: 10.1158/1078-0432.CCR-22-1238.
    PubMed     Abstract available


  62. SCHMITD LB, Perez-Pacheco C, Bellile EL, Wu W, et al
    Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer.
    Clin Cancer Res. 2022 Jul 12:OF1-OF16. doi: 10.1158/1078-0432.CCR-21-4543.
    PubMed     Abstract available


  63. LYNGGAARD CD, Gronhoj C, Jensen SB, Christensen R, et al
    Long-term Safety of Treatment with Autologous Mesenchymal Stem Cells in Patients with Radiation-Induced Xerostomia: Primary Results of the MESRIX Phase I/II Randomized Trial.
    Clin Cancer Res. 2022;28:2890-2897.
    PubMed     Abstract available


    June 2022
  64. ZHANG Z, Wu B, Peng G, Xiao G, et al
    Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial.
    Clin Cancer Res. 2022 Jun 29:OF1-OF9. doi: 10.1158/1078-0432.CCR-22-0666.
    PubMed     Abstract available


  65. SIHAG S, Nussenzweig SC, Walch HS, Hsu M, et al
    The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma.
    Clin Cancer Res. 2022;28:2669-2678.
    PubMed     Abstract available


  66. DUKE ES, Barone AK, Chatterjee S, Mishra-Kalyani PS, et al
    FDA Approval Summary: Cabozantinib for Differentiated Thyroid Cancer.
    Clin Cancer Res. 2022 Jun 9. pii: 704846. doi: 10.1158/1078-0432.CCR-22-0873.
    PubMed     Abstract available


  67. LEE KW, Van Cutsem E, Bang YJ, Fuchs CS, et al
    Association of Tumor Mutational Burden with Efficacy of Pembrolizumab{plus minus}Chemotherapy as First-Line Therapy for Gastric Cancer in the Phase III KEYNOTE-062 Study.
    Clin Cancer Res. 2022 Jun 3. pii: 699374. doi: 10.1158/1078-0432.CCR-22-0121.
    PubMed     Abstract available


  68. LEDDON JL, Gulati S, Haque S, Allen C, et al
    Phase 2 trial of adjuvant nivolumab following salvage resection in patients with recurrent squamous cell carcinoma of the head and neck.
    Clin Cancer Res. 2022 Jun 2. pii: 699312. doi: 10.1158/1078-0432.CCR-21-4554.
    PubMed     Abstract available


    May 2022
  69. WANG W, Lozar T, Golfinos AE, Lee D, et al
    Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.
    Clin Cancer Res. 2022 May 27:OF1-OF16. doi: 10.1158/1078-0432.CCR-21-3039.
    PubMed     Abstract available


  70. SCHMITD LB, Perez-Pacheco C, Bellile EL, Wu W, et al
    Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer.
    Clin Cancer Res. 2022 May 26. pii: 699248. doi: 10.1158/1078-0432.CCR-21-4543.
    PubMed     Abstract available


  71. WEBER M, Kersting D, Riemann B, Brandenburg T, et al
    Enhancing Radioiodine Incorporation Into Radio Iodine Refractory Thyroid Cancer With MAPK Inhibition (ERRITI): A Single-Center Prospective Two-Arm Study.
    Clin Cancer Res. 2022 May 20. pii: 699089. doi: 10.1158/1078-0432.CCR-22-0437.
    PubMed     Abstract available


  72. DENEKA AY, Baca Y, Serebriiskii IG, Nicolas E, et al
    Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer.
    Clin Cancer Res. 2022;28:1925-1937.
    PubMed     Abstract available


    April 2022
  73. LE X, Gleber-Netto FO, Rubin ML, Qing Y, et al
    Induction chemotherapy with or without erlotinib in patients with head and neck squamous cell carcinoma amenable for surgical resection.
    Clin Cancer Res. 2022 Apr 20. pii: 694632. doi: 10.1158/1078-0432.CCR-21-3239.
    PubMed     Abstract available


  74. FERRAROTTO R, Amit M, Nagarajan P, Rubin ML, et al
    Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
    Clin Cancer Res. 2022;28:1735.
    PubMed    


  75. LEE AW, Ng WT, Choi CW, But B, et al
    Exploratory Study of NPC-0501 Trial - Optimal Cisplatin Dose of Concurrent and Induction/Adjuvant Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma.
    Clin Cancer Res. 2022 Apr 5. pii: 694221. doi: 10.1158/1078-0432.CCR-21-3375.
    PubMed     Abstract available


  76. GUIX I, Liu Q, Pujana MA, Ha P, et al
    Validation of Anticorrelated TGFbeta Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy.
    Clin Cancer Res. 2022;28:1372-1382.
    PubMed     Abstract available


    March 2022
  77. CHUNG CH, Li J, Steuer CE, Bhateja P, et al
    Phase II multi-institutional clinical trial result of concurrent cetuximab and nivolumab in recurrent and/or metastatic head and neck squamous cell carcinoma.
    Clin Cancer Res. 2022 Mar 28. pii: 694028. doi: 10.1158/1078-0432.CCR-21-3849.
    PubMed     Abstract available


  78. OKADA M, Kato K, Cho BC, Takahashi M, et al
    Three-year follow-up and response-survival relationship of nivolumab in previously treated patients with advanced esophageal squamous cell carcinoma (ATTRACTION-3).
    Clin Cancer Res. 2022 Mar 16. pii: 682194. doi: 10.1158/1078-0432.CCR-21-0985.
    PubMed     Abstract available


  79. RICKELT S, Neyaz A, Condon C, Whittaker CA, et al
    Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker.
    Clin Cancer Res. 2022;28:1167-1179.
    PubMed     Abstract available


  80. OBRADOVIC A, Graves D, Korrer M, Wang Y, et al
    Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer.
    Clin Cancer Res. 2022 Mar 9. pii: 682113. doi: 10.1158/1078-0432.CCR-21-3570.
    PubMed     Abstract available


    February 2022
  81. WISE-DRAPER TM, Gulati S, Palackdharry S, Hinrichs BH, et al
    Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2022 Feb 28:OF1-OF8. doi: 10.1158/1078-0432.CCR-21-3351.
    PubMed     Abstract available


  82. XU Y, Dong B, Zhu W, Li J, et al
    A phase III multicenter randomized clinical trial of 60 Gy vs 50 Gy radiation dose in concurrent chemoradiotherapy for inoperable esophageal squamous cell carcinoma.
    Clin Cancer Res. 2022 Feb 18. pii: 681705. doi: 10.1158/1078-0432.CCR-21-3843.
    PubMed     Abstract available


  83. SACCO AG, Cohen EEW
    Inevitable Progress-Relying on the Immune System, Not Chance.
    Clin Cancer Res. 2022;28:435-437.
    PubMed     Abstract available


    January 2022
  84. FERRIS RL, Moskovitz J, Kunning S, Ruffin AT, et al
    Phase I trial of cetuximab, radiation therapy, and ipilimumab in locally advanced head and neck cancer.
    Clin Cancer Res. 2022 Jan 28. pii: 1078-0432.CCR-21-0426.
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    Afatinib and Pembrolizumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (ALPHA Study): A Phase II Study with Biomarker Analysis.
    Clin Cancer Res. 2022 Jan 19. pii: 1078-0432.CCR-21-3025.
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  86. LI Y, Yang X, Du X, Lei Y, et al
    Correction: RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
    Clin Cancer Res. 2022;28:430.
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  87. CAO Y, Haring CT, Brummel C, Bhambhani C, et al
    Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma.
    Clin Cancer Res. 2022;28:350-359.
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    December 2021
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    Therapy-related transcriptional subtypes in matched primary and recurrent head and neck cancer.
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  89. COHEN EEW, Nabell L, Wong DJ, Day T, et al
    Intralesional SD-101 in combination with pembrolizumab in anti-PD-1 treatment naive head and neck squamous cell carcinoma: results from a multicenter, phase 2 trial.
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  90. LUGINBUHL AJ, Johnson JM, Harshyne LA, Linnenbach AJ, et al
    Tadalafil enhances immune signatures in response to neoadjuvant nivolumab in resectable head and neck squamous cell carcinoma.
    Clin Cancer Res. 2021 Dec 15. pii: 1078-0432.CCR-21-1816.
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  91. YAP TA, Vieito M, Baldini C, Sepulveda-Sanchez JM, et al
    First-In-Human Phase I Study of a Next-Generation, Oral, TGFbeta Receptor 1 Inhibitor, LY3200882, in Patients with Advanced Cancer.
    Clin Cancer Res. 2021;27:6666-6676.
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  92. PANG J, Nguyen N, Luebeck J, Ball L, et al
    Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.
    Clin Cancer Res. 2021;27:6772-6786.
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    Safety and Efficacy of Pembrolizumab in Combination With Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study.
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  94. SIRAVEGNA G, O'Boyle CJ, Varmeh S, Queenan N, et al
    Cell free HPV DNA provides an accurate and rapid diagnosis of HPV-associated head and neck cancer.
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    Phase II, Randomized Study of Spartalizumab (PDR001), an Anti-PD-1 Antibody, versus Chemotherapy in Patients with Recurrent/Metastatic Nasopharyngeal Cancer.
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    November 2021
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    Multi-scale Pan-cancer Integrative Analyses Identify the STAT3-VSIR Axis as a key Immunosuppressive Mechanism in Head and Neck Cancer.
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  97. BICKETT TE, Knitz M, Darragh LB, Bhatia S, et al
    FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC.
    Clin Cancer Res. 2021;27:6235-6249.
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  98. LEUNG E, Han K, Zou J, Zhao Z, et al
    HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA.
    Clin Cancer Res. 2021;27:5857-5868.
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    October 2021
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    Neoadjuvant and adjuvant nivolumab and lirilumab in patients with recurrent, resectable squamous cell carcinoma of the head and neck.
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    September 2021
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    Correction: Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressiveness and Stem Cell-like Phenotype via Dysregulation of PITX2.
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  101. DE LA IGLESIA JV, Slebos RJC, Martin-Gomez L, Wang X, et al
    Correction: Effects of Tobacco Smoking On the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2021;27:4941.
    PubMed    


    August 2021
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    Recurrent human papillomavirus-related head and neck cancer undergoes metabolic re-programming and is driven by oxidative phosphorylation.
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    A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer.
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    July 2021
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    A randomized, phase 3 study of lenvatinib in Chinese patients with radioiodine-refractory differentiated thyroid cancer.
    Clin Cancer Res. 2021 Jul 29. pii: 1078-0432.CCR-21-0761.
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  105. BRAND TM, Hartmann S, Bhola NE, Peyser ND, et al
    Correction: Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV(+) Patients.
    Clin Cancer Res. 2021;27:4129.
    PubMed    


  106. KARPINETS TV, Mitani Y, Liu B, Zhang J, et al
    Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations.
    Clin Cancer Res. 2021;27:3960-3969.
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    Deep Learning for Fully Automated Prediction of Overall Survival in Patients with Oropharyngeal Cancer Using FDG-PET Imaging.
    Clin Cancer Res. 2021;27:3948-3959.
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    CD40 Agonist Targeted to Fibroblast Activation Protein alpha Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors.
    Clin Cancer Res. 2021;27:4054-4065.
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    Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study.
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    June 2021
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    Pilot phase II trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
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    Tumor-Naive Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma.
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  112. VAN DEN ENDE T, de Clercq NC, van Berge Henegouwen MI, Gisbertz SS, et al
    Neoadjuvant Chemoradiotherapy Combined with Atezolizumab for Resectable Esophageal Adenocarcinoma: A Single-arm Phase II Feasibility Trial (PERFECT).
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  113. PAPPA T, Ahmadi S, Marqusee E, Johnson HL, et al
    Oncogenic mutations in PI3K/AKT/mTOR pathway effectors associate with worse prognosis in BRAF(V600E)-driven papillary thyroid cancer patients.
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    Back from the Brink: EGFR Inhibition in Gastroesophageal Cancer.
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    A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies.
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  116. PENG Z, Wei J, Wang F, Ying J, et al
    Camrelizumab Combined with Chemotherapy Followed by Camrelizumab plus Apatinib as First-line Therapy for Advanced Gastric or Gastroesophageal Junction Adenocarcinoma.
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    Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas.
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    May 2021
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    Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes.
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    FDA Approval Summary: Pralsetinib for the Treatment of Lung and Thyroid cancers with RET gene mutations or fusions.
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    April 2021
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    Anlotinib in Locally Advanced or Metastatic Medullary Thyroid Carcinoma: A Randomized, Double-Blind Phase IIB Trial.
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    A PERFECT biomarker-focused study of neoadjuvant IO for esophagogastric cancer.
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    March 2021
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    Analyses of PD-L1 and Inflammatory Gene Expression Association with Efficacy of Nivolumab{plus minus}Ipilimumab in Gastric Cancer/Gastroesophageal Junction Cancer.
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    Combining Neratinib with CDK4/6, mTOR, and MEK Inhibitors in Models of HER2-positive Cancer.
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    February 2021
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    Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains.
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    Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
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    January 2021
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    December 2020
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    November 2020
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    FDA Approval Summary: Selpercatinib for the Treatment of Lung and Thyroid cancers with RET Gene Mutations or Fusions.
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    September 2020
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