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Articles published in Clin Cancer Res

Retrieve available abstracts of 130 articles:
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Single Articles


    July 2026
  1. AN PG, Zhang J, Hu X, Zhang ZQ, et al
    Preoperative Chemoimmunotherapy Followed by Salvage Surgery and Adjuvant Tislelizumab for Previously Irradiated Recurrent HNSCC: A Prospective Phase II Trial.
    Clin Cancer Res. 2026;32:2572-2580.
    PubMed     Abstract available


    June 2026
  2. VUJANOVIC L, Torres-Saavedra P, Tu F, Uppaluri R, et al
    Tumoral and Systemic Immune Correlates of Response to Concurrent Pembrolizumab and Chemoradiotherapy in Patients with Resected High-Risk Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2026 Jun 25:10.1158/1078-0432.CCR-25-4796.
    PubMed     Abstract available


  3. ZAMULKO O, Nusbaum S, Osterburg A, Crist M, et al
    A Phase 2 Feasibility Study Combining Pembrolizumab and Metformin in patients with Metastatic Head and Neck Cancer.
    Clin Cancer Res. 2026 Jun 25. doi: 10.1158/1078-0432.CCR-26-0874.
    PubMed     Abstract available


  4. LOW JL, Chong WQ, Hui EP, Tan TZ, et al
    A multicentre phase 2 study of trifluridine/tipiracil in recurrent/metastatic platinum resistant nasopharyngeal carcinomas.
    Clin Cancer Res. 2026 Jun 17. doi: 10.1158/1078-0432.CCR-26-1167.
    PubMed     Abstract available


  5. STRICKLER JH, Raimbourg J, Cohen JE, Ghiringhelli F, et al
    Telisotuzumab Adizutecan (ABBV-400), a Novel c-Met-Targeting Antibody-Drug Conjugate: First-in-Human Results in Advanced Gastric/Gastroesophageal Junction Cancer.
    Clin Cancer Res. 2026;32:2352-2361.
    PubMed     Abstract available


  6. XU C, Wang SY, Nie M, Yang KY, et al
    TQB2618 plus penpulimab, alone or in combination with chemotherapy, for recurrent or metastatic nasopharyngeal carcinoma: a multicentre, two-cohort, phase 2 trial.
    Clin Cancer Res. 2026 Jun 10. doi: 10.1158/1078-0432.CCR-26-0347.
    PubMed     Abstract available


  7. LEE KW, Elimova E, Oh DY, Beeram M, et al
    Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients with Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies.
    Clin Cancer Res. 2026;32:2136-2143.
    PubMed     Abstract available


  8. CHEN F, Zhou S, Ma J, Tao H, et al
    CCL3+ Neutrophil Signature Predicts Response to Neoadjuvant Toripalimab plus Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Phase II Trial.
    Clin Cancer Res. 2026;32:2166-2182.
    PubMed     Abstract available


  9. GE H, Li H, Kulkarni A, Chen Z, et al
    Preexisting TCR Clones Drive Major Pathologic Responses in Patients with HNSCC Treated with Dual Immune Checkpoint Inhibitors.
    Clin Cancer Res. 2026;32:2183-2197.
    PubMed     Abstract available


    May 2026
  10. SWIECICKI PL, Hanna GJ, Geiger JL, Fujisawa T, et al
    Enfortumab vedotin plus pembrolizumab as first-line treatment in recurrent or metastatic head and neck squamous cell carcinoma: results from EV-202 cohort 9.
    Clin Cancer Res. 2026 May 5. doi: 10.1158/1078-0432.CCR-25-4650.
    PubMed     Abstract available


    April 2026
  11. KONG Z, Liu Y, Lin YS, Li Z, et al
    Covalent FAPI Imaging-Guided Precision Surgery in Patients with Medullary Thyroid Carcinoma: A Phase II Clinical Trial.
    Clin Cancer Res. 2026 Apr 21:OF1-OF11. doi: 10.1158/1078-0432.CCR-25-3970.
    PubMed     Abstract available


  12. LI S, Wu CC, Marczyk VR, Loberg MA, et al
    PRECISE: A prognostic thyrocyte-derived gene signature for papillary thyroid carcinoma.
    Clin Cancer Res. 2026 Apr 20. doi: 10.1158/1078-0432.CCR-25-4488.
    PubMed     Abstract available


  13. XUE L, Han Y, Zhang Q, Li X, et al
    Becotatug Vedotin in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: A Multicenter, Phase IIa Trial.
    Clin Cancer Res. 2026;32:1445-1453.
    PubMed     Abstract available


  14. SHI F, Chai W, Yang H, Cao W, et al
    AL2846, a novel multi-kinase inhibitor, for previously treated radioiodine-refractory differentiated thyroid cancer: Exploratory clinical results from the phase Ib study.
    Clin Cancer Res. 2026 Apr 9. doi: 10.1158/1078-0432.CCR-25-3945.
    PubMed     Abstract available


  15. GARRALDA E, Markert C, Moreno V, Calvo E, et al
    A first-in-human phase 1 clinical trial evaluating clinical activity and proof-of-mechanism of tobemstomig, a PD1-LAG3 bispecific antibody, in patients with CPI-experienced melanoma.
    Clin Cancer Res. 2026 Apr 7. doi: 10.1158/1078-0432.CCR-25-4478.
    PubMed     Abstract available


  16. VEMULAMANDA S, Kothari A, De Cecco L, Kim S, et al
    Development of a Clinical Assay to Guide Patient Therapy in HPV-Associated Head and Neck Cancer.
    Clin Cancer Res. 2026 Apr 1. doi: 10.1158/1078-0432.CCR-25-2159.
    PubMed     Abstract available


    March 2026
  17. CAI J, Zhao B, Ji D, Zhou F, et al
    LM-101, an anti-SIRPalpha antibody, in patients with relapsed/refractory lymphoma and advanced head and neck cancer: an open-label, multicenter, phase 1 trial.
    Clin Cancer Res. 2026 Mar 30. doi: 10.1158/1078-0432.CCR-25-2357.
    PubMed     Abstract available


  18. VAN DER ELST A, Herrero-Saboya D, Michon L, Morfouace M, et al
    Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an EORTC/IMMUCAN project.
    Clin Cancer Res. 2026 Mar 23. doi: 10.1158/1078-0432.CCR-25-3377.
    PubMed     Abstract available


  19. ANDERSON JL, Sikora AG
    Neoadjuvant chemoimmunotherapy improves response rates in head and neck cancer.
    Clin Cancer Res. 2026 Mar 17. doi: 10.1158/1078-0432.CCR-25-4813.
    PubMed     Abstract available


  20. GOLFINOS-OWENS AE, Lozar T, Khatri P, Johns ED, et al
    Integrated single-cell and spatial analysis reveals context-dependent myeloid-T cell interactions in response to immune checkpoint blockade in head and neck cancer.
    Clin Cancer Res. 2026 Mar 16. doi: 10.1158/1078-0432.CCR-25-2300.
    PubMed     Abstract available


  21. YANG Y, Yan X, Jiang H, Kang M, et al
    PET/CT-Guided Neoadjuvant Tislelizumab Plus Chemotherapy/Chemoradiotherapy for Resectable Esophageal Squamous Cell Carcinoma: RATIONALE-213 Final Analysis.
    Clin Cancer Res. 2026 Mar 2. doi: 10.1158/1078-0432.CCR-25-2367.
    PubMed     Abstract available


    February 2026
  22. YIN S, Cheng L, Hu E, Li J, et al
    Association of Intratumoral Microbiota with Prognosis in Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2026 Feb 27. doi: 10.1158/1078-0432.CCR-25-4420.
    PubMed     Abstract available


  23. MIERZWA M, Rosen B, Suresh K, Dinesh A, et al
    FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial.
    Clin Cancer Res. 2026;32:684-693.
    PubMed     Abstract available


  24. LI JZ, Ricarte Filho J, Isaza AR, Hinkle K, et al
    DNA Methylation-based Risk Stratification and Classification of Pediatric Thyroid Carcinoma.
    Clin Cancer Res. 2026 Feb 17. doi: 10.1158/1078-0432.CCR-25-2109.
    PubMed     Abstract available


  25. MICHAL M, Malik F, Mansour B, Hattery T, et al
    FET-Rearranged Myoepithelial Tumors Are Clinically Heterogeneous and Epigenetically Distinct from PLAG1-Rearranged Adnexal and Salivary Gland Myoepithelial Tumors.
    Clin Cancer Res. 2026;32:628-644.
    PubMed     Abstract available


    January 2026
  26. PRASAD M, Cheng AT, Mayer M, Jansen L, et al
    Genomic enrichment and functional impact of TP53 and CYLD alterations in recurrent and metastatic HPV-associated head and neck cancer.
    Clin Cancer Res. 2026 Jan 28. doi: 10.1158/1078-0432.CCR-25-3972.
    PubMed     Abstract available


  27. LEE KW, Bai LY, Jung M, Ying J, et al
    Phase Ib/II Study of Zanidatamab in Combination with Tislelizumab and Chemotherapy in First-Line HER2-Positive Gastric/Gastroesophageal Junction Adenocarcinoma.
    Clin Cancer Res. 2026;32:312-323.
    PubMed     Abstract available


  28. LI Q, Fu M, Kuang D, Pan C, et al
    A Phase II Trial of Neoadjuvant Albumin-Bound Paclitaxel plus Carboplatin Combined with Tislelizumab in Locally Advanced HNSCC: Efficacy and Biomarker Exploration.
    Clin Cancer Res. 2026;32:324-332.
    PubMed     Abstract available


  29. CHIRRA M, Elliott A, Shaikh H, McGrath J, et al
    Molecular Profiling and Real-World Outcomes of BRAF V600E-Mutated Papillary Thyroid Cancer.
    Clin Cancer Res. 2026 Jan 16. doi: 10.1158/1078-0432.CCR-25-3932.
    PubMed     Abstract available


  30. JIANG L, Li X, Ma T, Zeng P, et al
    Clinical Significance for risk stratification of papillary thyroid cancer by TUMORFISHER circulating tumor cells technique.
    Clin Cancer Res. 2026 Jan 16. doi: 10.1158/1078-0432.CCR-25-2694.
    PubMed     Abstract available


  31. HANNA GJ, Scarfo N, Shin KY, O'Neill A, et al
    Elraglusib, a Glycogen Synthase Kinase 3beta Inhibitor, plus Chemotherapy with or without Immunotherapy in Patients with Recurrent, Metastatic Salivary Gland Carcinoma.
    Clin Cancer Res. 2026;32:83-93.
    PubMed     Abstract available


    December 2025
  32. RISCHIN D, Hansen AR, Cohen EEW, Tahara M, et al
    INDUCE-3: A randomized Phase II/III study of first-line feladilimab plus pembrolizumab in patients with recurrent/metastatic head and neck squamous cell carcinoma.
    Clin Cancer Res. 2025 Dec 22. doi: 10.1158/1078-0432.CCR-25-1197.
    PubMed     Abstract available


  33. SANZ-GARCIA E, Soleimani S, Bruce JP, Pedersen S, et al
    Investigating Early Kinetics in Plasma ctDNA and Peripheral T Cell Receptor Repertoire to Predict Treatment Outcomes to PD-1 Inhibitors in Head and Neck Cancer.
    Clin Cancer Res. 2025 Dec 19. doi: 10.1158/1078-0432.CCR-25-3541.
    PubMed     Abstract available


  34. LLERENA P, Samarah H, Nunes K, Lin Z, et al
    Extracellular Matrix-MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC.
    Clin Cancer Res. 2025;31:5159-5177.
    PubMed     Abstract available


  35. ZINNER RG, Mastrolonardo EV, Johnson JM, Nunes K, et al
    Neoadjuvant nivolumab plus carboplatin and paclitaxel in patients with locally advanced resectable squamous cell carcinoma of the head and neck: a phase II, single-arm trial.
    Clin Cancer Res. 2025 Dec 12. doi: 10.1158/1078-0432.CCR-25-2807.
    PubMed     Abstract available


  36. SUN D, Chen G, Chen Y, Qu S, et al
    Anti-LAG-3 Antibody LBL-007 Plus Tislelizumab and Chemotherapy as First-Line Therapy for Advanced Nasopharyngeal Carcinoma: A Multicenter Phase 2 Trial.
    Clin Cancer Res. 2025 Dec 11. doi: 10.1158/1078-0432.CCR-25-2054.
    PubMed     Abstract available


    November 2025
  37. LI S, Xia S, Lawas M, Kulshreshtha A, et al
    HPV integration in head and neck cancer: downstream splicing events and expression ratios linked with poor outcomes.
    Clin Cancer Res. 2025 Nov 21. doi: 10.1158/1078-0432.CCR-25-0645.
    PubMed     Abstract available


  38. KORNS J, Lehn MA, Shyamsunder S, Medvedovic M, et al
    Targeting PLK1 Reduces MMP10 to Enhance Radiosensitivity in HPV- Head and Neck Cancer.
    Clin Cancer Res. 2025 Nov 18. doi: 10.1158/1078-0432.CCR-25-2179.
    PubMed     Abstract available


  39. LAZARE S, Gu Z, Earland N, Harmon MA, et al
    Postoperative Lymph is a Proximal Source of ctDNA for Detection of Recurrence in HPV-independent Head and Neck Cancer.
    Clin Cancer Res. 2025 Nov 3. doi: 10.1158/1078-0432.CCR-25-1221.
    PubMed     Abstract available


    October 2025
  40. CHAUDHARY R, Moorhead G, Park R, Li J, et al
    Long-term Survival and Molecular Biomarker Evaluation of a Phase II Cetuximab and Nivolumab Clinical Trial in Recurrent/Metastatic Head and Neck Cancer.
    Clin Cancer Res. 2025 Oct 21. doi: 10.1158/1078-0432.CCR-25-2201.
    PubMed     Abstract available


    September 2025
  41. SEHGAL K
    Personalized Thyroidology: Molecular Rewiring of Thyroid Nodule Management.
    Clin Cancer Res. 2025 Sep 26. doi: 10.1158/1078-0432.CCR-25-2474.
    PubMed     Abstract available


    August 2025
  42. HARING CT, Windon MJ, Heft-Neal ME, Brenner JC, et al
    Toward a Next-Generation Liquid Biopsy for HPV+ HNSCC: Opportunities, Challenges, and the Road Ahead.
    Clin Cancer Res. 2025;31:3359-3361.
    PubMed     Abstract available


  43. HONORE N, Laliotis G, Aushev VN, Velichko S, et al
    Tumor-informed ctDNA assay to predict outcome in recurrent and/or metastatic squamous cell carcinoma of the head and neck treated with PD-1 inhibitor.
    Clin Cancer Res. 2025 Aug 11. doi: 10.1158/1078-0432.CCR-25-1309.
    PubMed     Abstract available


  44. ROSENBERG AJ, Izumchenko E, Juloori A, Katipally R, et al
    Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus-Associated Oropharyngeal Cancer.
    Clin Cancer Res. 2025;31:3150-3159.
    PubMed     Abstract available


  45. FU ZM, Bao YY, Dai LB, Zhong JT, et al
    Comprehensive Single-Cell RNA Atlas of Human Laryngeal Normal, Preneoplastic, and Tumorigenic States.
    Clin Cancer Res. 2025;31:3332-3343.
    PubMed     Abstract available


    July 2025
  46. PATEL R, Saab K, Luo L, Ma Y, et al
    Nrf2 hyperactivation as a driver of radiotherapy resistance and suppressed anti-tumor immunity in head and neck squamous cell carcinoma.
    Clin Cancer Res. 2025 Jul 31. doi: 10.1158/1078-0432.CCR-25-0112.
    PubMed     Abstract available


  47. CAO F, Li Y, Fang Q, Lin R, et al
    Cadonilimab (a PD-1/CTLA-4 bispecific antibody) Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase ? Clinical Trial.
    Clin Cancer Res. 2025 Jul 24. doi: 10.1158/1078-0432.CCR-25-1445.
    PubMed     Abstract available


    June 2025
  48. HARRISON C, Blake AK, Su Y, Tang L, et al
    Contribution of Germline Predisposition to Pediatric Thyroid Cancer.
    Clin Cancer Res. 2025 Jun 27. doi: 10.1158/1078-0432.CCR-25-0631.
    PubMed     Abstract available


  49. DING M, Wu G, Zhang S, Xie R, et al
    Clinical implications and application of molecular testing in the diagnosis and management of thyroid nodules in the Chinese population.
    Clin Cancer Res. 2025 Jun 27. doi: 10.1158/1078-0432.CCR-25-0270.
    PubMed     Abstract available


  50. SABA NF, Flamand Y, Lin DT, Chung CH, et al
    Neoadjuvant Chemotherapy and Surgery versus Surgery for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma: ECOG-ACRIN EA3163.
    Clin Cancer Res. 2025;31:2339-2346.
    PubMed     Abstract available


  51. TANG LQ, Liu SL, Yang MH, Wang HC, et al
    GFH018 and toripalimab combination therapy for previously treated recurrent or metastatic nasopharyngeal carcinoma: Results from a phase 1b/2 study.
    Clin Cancer Res. 2025 Jun 13. doi: 10.1158/1078-0432.CCR-25-0085.
    PubMed     Abstract available


    May 2025
  52. DHOLARIA H, Tsetlina V, Simpson SK, Gillies E, et al
    One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma.
    Clin Cancer Res. 2025 May 30. doi: 10.1158/1078-0432.CCR-24-3546.
    PubMed     Abstract available


  53. BRYAN ME, Aye L, Das D, Hirayama S, et al
    Direct Comparison of Alternative Blood-Based Approaches for Early Detection and Diagnosis of HPV-Associated Head and Neck Cancers.
    Clin Cancer Res. 2025 May 20:OF1-OF11. doi: 10.1158/1078-0432.CCR-24-2525.
    PubMed     Abstract available


  54. SIM ES, Rhoades J, Xiong K, Walsh L, et al
    Early Postoperative Minimal Residual Disease Detection with MAESTRO Is Associated with Recurrence and Worse Survival in Patients with Head and Neck Cancer.
    Clin Cancer Res. 2025 May 20:OF1-OF9. doi: 10.1158/1078-0432.CCR-25-0307.
    PubMed     Abstract available


  55. CAO X, Luo ZY, Huang HY, Zhou JY, et al
    Capecitabine maintenance therapy in patients with residual nasopharyngeal carcinoma: a single-arm, phase 2 trial.
    Clin Cancer Res. 2025 May 19. doi: 10.1158/1078-0432.CCR-24-4132.
    PubMed     Abstract available


  56. ALSINA M, Villacampa G, de Andrea C, Vivancos A, et al
    Phase II study of perioperative Avelumab plus chemotherapy for patients with resectable gastric cancer or gastroesophageal junction cancer - the MONEO Study.
    Clin Cancer Res. 2025 May 19. doi: 10.1158/1078-0432.CCR-25-0369.
    PubMed     Abstract available


  57. ZHANG W, Li JB, Liu HM, Wang KM, et al
    PERK+ Macrophages Drive Immunotherapy Resistance in Lymph Node Metastases of Oral Squamous Cell Carcinoma.
    Clin Cancer Res. 2025;31:1894-1911.
    PubMed     Abstract available


  58. SCHMITT NC, Stokes WA, Bates JE, Kinney BLC, et al
    Early-phase trial of IAP antagonist tolinapant and definitive radiation in cisplatin-ineligible patients with advanced head and neck cancer.
    Clin Cancer Res. 2025 May 12. doi: 10.1158/1078-0432.CCR-25-0429.
    PubMed     Abstract available


  59. CALIFANO JA
    So Close, and Yet... Plasma HPV DNA Detection of Recurrent HPV Oropharynx Cancer.
    Clin Cancer Res. 2025;31:1561-1562.
    PubMed     Abstract available


  60. QIAN Y, Tang L, Yao J, Zhu Y, et al
    Pembrolizumab with Chemotherapy for Patients with Recurrent or Metastatic Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma: A Prospective Phase ll Study.
    Clin Cancer Res. 2025;31:1636-1643.
    PubMed     Abstract available


  61. BARTEMES KR, Moore RM, Novotny BC, Pavelko KD, et al
    Increased Interaction between B Cells and CD3+ T Cells in Nonprogressors with Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.
    Clin Cancer Res. 2025;31:1719-1729.
    PubMed     Abstract available


  62. RETTIG EM, Schoenfeld JD, Miller J, Sargent B, et al
    A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue-Modified Viral HPV DNA.
    Clin Cancer Res. 2025;31:1605-1614.
    PubMed     Abstract available


  63. GUAN L, Torres-Saavedra PA, Zhao X, Major MB, et al
    Association between Locoregional Failure and NFE2L2/KEAP1/CUL3 Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer.
    Clin Cancer Res. 2025;31:1615-1624.
    PubMed     Abstract available


  64. PEREZ-PACHECO CG, Gonzalez-Maldonado LA, Furgal A, Schmitd LB, et al
    Nerve Types and Classification of Neurons Innervating Oral Cancer.
    Clin Cancer Res. 2025 May 1. doi: 10.1158/1078-0432.CCR-24-2375.
    PubMed     Abstract available


    April 2025
  65. FAYETTE J, Licitra L, Harrington K, Haddad R, et al
    INTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab Plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2025 Apr 29. doi: 10.1158/1078-0432.CCR-25-0073.
    PubMed     Abstract available


  66. WALCH HS, Borpatragohain R, Jee J, Chatila W, et al
    Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer.
    Clin Cancer Res. 2025 Apr 29:OF1-OF10. doi: 10.1158/1078-0432.CCR-24-3473.
    PubMed     Abstract available


    March 2025
  67. MCCOON P, Wang Y, Lai Z, Zhang Q, et al
    Mutational Landscape of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Association with Immune Checkpoint Inhibitor Outcome.
    Clin Cancer Res. 2025 Mar 13. doi: 10.1158/1078-0432.CCR-24-2198.
    PubMed     Abstract available


  68. LEE J, Shin Y, Kwak J, Park HL, et al
    Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer.
    Clin Cancer Res. 2025 Mar 12. doi: 10.1158/1078-0432.CCR-24-3562.
    PubMed     Abstract available


  69. TSENG I, Chen Y, Ai D, Zhu Z, et al
    Radiation Dose-Volume Effects on Negative Tumor-Draining Lymph Nodes Impacted T-Cell Activation and Prognosis in Esophageal Cancer with Chemoradiotherapy.
    Clin Cancer Res. 2025 Mar 7. doi: 10.1158/1078-0432.CCR-24-4123.
    PubMed     Abstract available


  70. COLEVAS AD, Talebi Z, Winters E, Even C, et al
    First-in-Human Clinical Trial of a Small-Molecule EBNA1 Inhibitor, VK-2019, in Patients with Epstein-Barr-Positive Nasopharyngeal Cancer, with Pharmacokinetic and Pharmacodynamic Studies.
    Clin Cancer Res. 2025;31:815-823.
    PubMed     Abstract available


    February 2025
  71. RAO YJ
    Biomarkers of radioresistance in head and neck cancer: a new beginning.
    Clin Cancer Res. 2025 Feb 18. doi: 10.1158/1078-0432.CCR-24-4223.
    PubMed     Abstract available


  72. WANG C, Niu X, Xia T, Wang P, et al
    Predicting c-KIT Inhibitor Efficacy in Patient-Derived Models of Sinonasal Mucosal Melanomas through Integrated Histogram Analysis of Whole-Tumor DKI, IVIM, and DCE-MRI.
    Clin Cancer Res. 2025 Feb 12. doi: 10.1158/1078-0432.CCR-24-3765.
    PubMed     Abstract available


    January 2025
  73. CONTRERA KJ, Ferrarotto R, Gunn B, Su SY, et al
    Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma.
    Clin Cancer Res. 2025;31:258-265.
    PubMed     Abstract available


  74. HUANG YJ, Rieder J, Tan KV, Tenditnaya A, et al
    Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.
    Clin Cancer Res. 2025;31:98-109.
    PubMed     Abstract available


  75. FENGER CARLANDER AL, Jakobsen KK, Todsen T, Paaske N, et al
    Long-term effect and safety of mesenchymal stromal cell therapy for radiation-induced hyposalivation in head and neck cancer survivors: A randomised, phase-2, trial.
    Clin Cancer Res. 2025 Jan 3. doi: 10.1158/1078-0432.CCR-24-2663.
    PubMed     Abstract available


    December 2024
  76. MASON RP
    Tumor Hypoxia: Long Ignored but Now Detectable and Potentially Actionable.
    Clin Cancer Res. 2024;30:5503-5504.
    PubMed     Abstract available


  77. DUBEC MJ, Price J, Berks M, Gaffney J, et al
    Oxygen-Enhanced MRI Detects Incidence, Onset, and Heterogeneity of Radiation-Induced Hypoxia Modification in HPV-Associated Oropharyngeal Cancer.
    Clin Cancer Res. 2024;30:5620-5629.
    PubMed     Abstract available


  78. MICHEL L, Jimeno A, Sukari A, Beck JT, et al
    Sacituzumab Govitecan in Patients With Relapsed/Refractory Advanced Head and Neck Squamous Cell Carcinoma: Results From the Phase 2 TROPiCS-03 Basket Study.
    Clin Cancer Res. 2024 Dec 12. doi: 10.1158/1078-0432.CCR-24-2523.
    PubMed     Abstract available


  79. HANNA GJ, Oakley LB, Shi R, ONeill A, et al
    Duvelisib with docetaxel for patients with anti-PD-1 refractory, recurrent or metastatic head and neck squamous cell carcinoma.
    Clin Cancer Res. 2024 Dec 3. doi: 10.1158/1078-0432.CCR-24-2262.
    PubMed     Abstract available


    November 2024
  80. JOHNSON FM, O'Hara MP, Yapindi L, Jiang P, et al
    Phase 1/2 Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas.
    Clin Cancer Res. 2024 Nov 26. doi: 10.1158/1078-0432.CCR-24-2290.
    PubMed     Abstract available


  81. MASTROLONARDO EV, Nunes KL, Llerena P, Nikitina A, et al
    Response-Adaptive Surgical Timing in neoadjuvant immunotherapy demonstrates enhanced pathologic treatment response in Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2024 Nov 25. doi: 10.1158/1078-0432.CCR-24-0037.
    PubMed     Abstract available


  82. WANG X, Kang X, Zhang R, Xue L, et al
    Chemoradiotherapy and Subsequent Immunochemotherapy as Conversion Therapy in Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Phase II NEXUS-1 Trial.
    Clin Cancer Res. 2024;30:5061-5072.
    PubMed     Abstract available


  83. LI Q, Zhang W, Liao T, Gao Y, et al
    An AI-driven preoperative radiomic subtype for predicting the prognosis and treatment response of patients with papillary thyroid carcinoma.
    Clin Cancer Res. 2024 Nov 13. doi: 10.1158/1078-0432.CCR-24-2356.
    PubMed     Abstract available


    October 2024
  84. HANSEN AR, Gomez-Roca CA, Robbrecht DGJ, Verlingue L, et al
    Phase 1b Study of the Immunocytokine Simlukafusp alfa (FAP-IL2v), in Combination with Cetuximab in Patients with Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2024 Oct 18. doi: 10.1158/1078-0432.CCR-24-1562.
    PubMed     Abstract available


  85. CHAMSEDDINE I, Shah K, Lee H, Ehret F, et al
    Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis.
    Clin Cancer Res. 2024;30:4424-4433.
    PubMed     Abstract available


    September 2024
  86. BARRETT AM, Britton ZT, Carrasco RA, Breen S, et al
    Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancer.
    Clin Cancer Res. 2024 Sep 25. doi: 10.1158/1078-0432.CCR-24-1853.
    PubMed     Abstract available


  87. STONE LD, Kasten BB, Rao S, Gonzalez ML, et al
    Interim Phase II Results Using Panitumumab-IRDye800CW during Transoral Robotic Surgery in Patients with Oropharyngeal Cancer.
    Clin Cancer Res. 2024;30:4016-4028.
    PubMed     Abstract available


  88. WARNER BE, Patel J, Wang R, Adams-Haduch J, et al
    The Epstein-Barr virus nuclear antigen 1 variant associated with nasopharyngeal carcinoma defines the sequence criteria for serologic risk prediction.
    Clin Cancer Res. 2024 Sep 12. doi: 10.1158/1078-0432.CCR-24-1142.
    PubMed     Abstract available


    August 2024
  89. SABA NF, Chaudhary R, Kirtane K, Marra A, et al
    Pembrolizumab and cabozantinib in recurrent and/or metastatic head and neck squamous cell carcinoma (RMHNSCC): long-term survival update with a biomarker analysis.
    Clin Cancer Res. 2024 Aug 21. doi: 10.1158/1078-0432.CCR-24-1202.
    PubMed     Abstract available


  90. HONMA Y, Monden N, Yamazaki K, Kano S, et al
    Apalutamide and Goserelin for Androgen Receptor-Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU.
    Clin Cancer Res. 2024;30:3416-3427.
    PubMed     Abstract available


    July 2024
  91. FORSTER M, Brana I, Lopez Pousa A, Doger B, et al
    Eftilagimod alpha (soluble LAG-3 protein) combined with pembrolizumab as second-line therapy for patients with metastatic head and neck squamous cell carcinoma.
    Clin Cancer Res. 2024 Jul 12. doi: 10.1158/1078-0432.CCR-24-0473.
    PubMed     Abstract available


    June 2024
  92. FRENCH JD, Haugen BR, Worden FP, Bowles DW, et al
    Combination Targeted Therapy with Lenvatinib and Pembrolizumab in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers.
    Clin Cancer Res. 2024 Jun 26. doi: 10.1158/1078-0432.CCR-23-3417.
    PubMed     Abstract available


  93. HANNA GJ, Dennis MJ, Scarfo N, Mullin MS, et al
    Personalized circulating tumor DNA for monitoring disease status in head and neck squamous cell carcinoma.
    Clin Cancer Res. 2024 Jun 2. doi: 10.1158/1078-0432.CCR-24-0590.
    PubMed     Abstract available


    May 2024
  94. SCHMIDT I, Zhao X, van der Waaij AM, Meersma GJ, et al
    Ultrasound-guided quantitative fluorescence molecular endoscopy for monitoring response in patients with esophageal cancer following neoadjuvant chemoradiotherapy.
    Clin Cancer Res. 2024 May 30. doi: 10.1158/1078-0432.CCR-24-0446.
    PubMed     Abstract available


  95. BALLOUT F, Lu H, Bhat N, Chen L, et al
    Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair.
    Clin Cancer Res. 2024;30:2193-2205.
    PubMed     Abstract available


  96. HANNA GJ, Grover P, Elliott A, McGrath J, et al
    Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II.
    Clin Cancer Res. 2024;30:2225-2232.
    PubMed     Abstract available


  97. PENG X, Zhao H, Ye L, Hou F, et al
    Biomarker identification and risk prediction model development for differentiated thyroid carcinoma lung metastasis based on primary lesion proteomics.
    Clin Cancer Res. 2024 May 9. doi: 10.1158/1078-0432.CCR-23-3806.
    PubMed     Abstract available


  98. TANG T, Zhou Z, Chen M, Li N, et al
    Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial.
    Clin Cancer Res. 2024 May 7. doi: 10.1158/1078-0432.CCR-23-3608.
    PubMed     Abstract available


  99. PRENEN H, Deva S, Keam B, Lindsay CR, et al
    Phase II study to determine the anti-tumor activity and safety of simlukafusp alfa (FAP-IL2v) combined with atezolizumab in esophageal cancer.
    Clin Cancer Res. 2024 May 6. doi: 10.1158/1078-0432.CCR-23-2677.
    PubMed     Abstract available


  100. ROSS RB, Gadwa J, Yu J, Darragh LB, et al
    PPARalpha Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counteraction.
    Clin Cancer Res. 2024;30:1916-1933.
    PubMed     Abstract available


  101. LIU Y, Yan W, Hu C, Huang X, et al
    Optimizing Cervical Target Volume in Patients with Nasopharyngeal Cancer Based On Nodal Drainage Distance.
    Clin Cancer Res. 2024;30:1801-1810.
    PubMed     Abstract available


    April 2024
  102. SHANNON NB, Iyer NG
    Unveiling Liquid Gold: Lymph as an HPV Marker in OPSCC to Guide Treatment Decisions.
    Clin Cancer Res. 2024;30:1223-1225.
    PubMed     Abstract available


  103. EARLAND N, Semenkovich NP, Ramirez RJ, Gerndt SP, et al
    Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer.
    Clin Cancer Res. 2024;30:1409-1421.
    PubMed     Abstract available


  104. READ ML, Brookes K, Zha L, Manivannan S, et al
    Combined Vorinostat and Chloroquine Inhibit Sodium-Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo.
    Clin Cancer Res. 2024;30:1352-1366.
    PubMed     Abstract available


    March 2024
  105. ZANONI DK, Demetrio De Souza Franca P, Valero C, Peterson G, et al
    A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer.
    Clin Cancer Res. 2024 Mar 25. doi: 10.1158/1078-0432.CCR-23-1361.
    PubMed     Abstract available


  106. SWIECICKI PL, Bellile E, Dragovic AF, McHugh J, et al
    Upfront neck dissection for treatment selection and improvement in quality of life as a novel treatment paradigm for deintensification in HPV+ OPSCC.
    Clin Cancer Res. 2024 Mar 22. doi: 10.1158/1078-0432.CCR-23-3247.
    PubMed     Abstract available


  107. KIM CG, Hong MH, Kim D, Lee BH, et al
    A phase II open-label randomized clinical trial of preoperative durvalumab or durvalumab plus tremelimumab in resectable head and neck squamous cell carcinoma.
    Clin Cancer Res. 2024 Mar 8. doi: 10.1158/1078-0432.CCR-23-3249.
    PubMed     Abstract available


  108. JAKOBSEN K, Carlander AF, Todsen T, Melchiors J, et al
    Mesenchymal Stem/Stromal Cell Therapy for Radiation-Induced Xerostomia in Previous Head and Neck Cancer Patients: A Phase 2 Randomised, Placebo-Controlled Trial.
    Clin Cancer Res. 2024 Mar 5. doi: 10.1158/1078-0432.CCR-23-3675.
    PubMed     Abstract available


    February 2024
  109. SAITO S, Kono M, Nguyen HCB, Egloff AM, et al
    Targeting Dendritic Cell Dysfunction to Circumvent anti-PD1 Resistance in Head and Neck Cancer.
    Clin Cancer Res. 2024 Feb 19. doi: 10.1158/1078-0432.CCR-23-3477.
    PubMed     Abstract available


    January 2024
  110. MEHANNA H, Rapozo D, von Zeidler SV, Harrington KJ, et al
    Developing and Validating a Multivariable Prognostic-Predictive Classifier for Treatment Escalation of Oropharyngeal Squamous Cell Carcinoma: The PREDICTR-OPC Study.
    Clin Cancer Res. 2024;30:356-367.
    PubMed     Abstract available


  111. LECHNER MG, Brent GA
    A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer.
    Clin Cancer Res. 2024 Jan 10. doi: 10.1158/1078-0432.CCR-23-3503.
    PubMed     Abstract available


  112. VON WITZLEBEN A, Ellis M, Thomas GJ, Hoffmann TK, et al
    Tumor-Infiltrating CD103+ Tissue-Resident Memory T Cells and CD103-CD8+ T Cells in HNSCC Are Linked to Outcome in Primary but not Metastatic Disease.
    Clin Cancer Res. 2024;30:224-234.
    PubMed     Abstract available


  113. PENA-OYARZUN D, Flores T, Torres VA, Quest AFG, et al
    Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis.
    Clin Cancer Res. 2024;30:209-223.
    PubMed     Abstract available


    December 2023
  114. KIM YH, Yoon SJ, Kim M, Kim HH, et al
    Integrative multi-omics analysis reveals different metabolic phenotypes based on molecular characteristics in thyroid cancer.
    Clin Cancer Res. 2023 Dec 13. doi: 10.1158/1078-0432.CCR-23-2025.
    PubMed     Abstract available


    November 2023
  115. NGAMPHAIBOON N, Pattaranutaporn P, Lukerak S, Siripoon T, et al
    A Phase I Study of the CDK4/6 Inhibitor, Palbociclib in Combination with Cetuximab and Radiotherapy (IMRT) for Locally Advanced Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2023 Nov 20. doi: 10.1158/1078-0432.CCR-23-2303.
    PubMed     Abstract available


  116. OU X, Zhai R, Wei W, Chen J, et al
    Induction Toripalimab And Chemotherapy For Organ Preservation In Locally Advanced Laryngeal And Hypopharyngeal Cancer: A Single-Arm Phase 2 Clinical Trial.
    Clin Cancer Res. 2023 Nov 13. doi: 10.1158/1078-0432.CCR-23-2398.
    PubMed     Abstract available


  117. SHEN C, Shi X, Wen D, Zhang Y, et al
    Comprehensive DNA Methylation Profiling of Medullary Thyroid Carcinoma: Molecular Classification, Potential Therapeutic Target, and Classifier System.
    Clin Cancer Res. 2023 Nov 6. doi: 10.1158/1078-0432.CCR-23-2142.
    PubMed     Abstract available


    October 2023
  118. HANNA GJ, Roof SA, Jabalee J, Rettig EM, et al
    Negative Predictive Value of Circulating Tumor Tissue Modified Viral (TTMV)-HPV DNA for HPV-driven Oropharyngeal Cancer Surveillance.
    Clin Cancer Res. 2023;29:4306-4313.
    PubMed     Abstract available


  119. BEYAERT SP, Loriot AE, Huyghe ND, Goebbels RM, et al
    Tumor Microenvironment Modifications Induced by Afatinib in Squamous Cell Carcinoma of the Head and Neck: A Window-of-Opportunity Study (EORTC-90111-24111).
    Clin Cancer Res. 2023;29:4076-4087.
    PubMed     Abstract available


  120. PIFER PM, Yang L, Kumar M, Xie T, et al
    FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.
    Clin Cancer Res. 2023 Oct 11. doi: 10.1158/1078-0432.CCR-23-0964.
    PubMed     Abstract available


  121. FU H, Huang J, Zhao T, Wang H, et al
    Fibroblast Activation Protein-Targeted Radioligand Therapy with 177Lu-EB-FAPI for Metastatic Radioiodine Refractory Thyroid Cancer: First-in-Human, Dose-Escalation Study.
    Clin Cancer Res. 2023 Oct 6. doi: 10.1158/1078-0432.CCR-23-1983.
    PubMed     Abstract available


  122. KLEMPNER SJ, Lee KW, Shitara K, Metges JP, et al
    ILUSTRO: Phase II Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma.
    Clin Cancer Res. 2023;29:3882-3891.
    PubMed     Abstract available


  123. JAKOBSEN KK, Bendtsen SK, Pallisgaard N, Friborg J, et al
    Liquid Biopsies with Circulating Plasma HPV-DNA Measurements-A Clinically Applicable Surveillance Tool for Patients with HPV-Positive Oropharyngeal Cancer.
    Clin Cancer Res. 2023;29:3914-3923.
    PubMed     Abstract available


    September 2023
  124. DERRY JMJ, Burns C, Frazier JP, Beirne E, et al
    Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.
    Clin Cancer Res. 2023;29:3813-3825.
    PubMed     Abstract available


  125. DUKE ES, Bradford D, Marcovitz M, Amatya AK, et al
    FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
    Clin Cancer Res. 2023;29:3573-3578.
    PubMed     Abstract available


  126. LEE MS, Kaseb AO, Pant S
    The Emerging Role of Circulating Tumor DNA in Non-Colorectal Gastrointestinal Cancers.
    Clin Cancer Res. 2023;29:3267-3274.
    PubMed     Abstract available


    August 2023
  127. CHI Y, Zheng X, Zhang Y, Shi F, et al
    Anlotinib in Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma: A Randomized, Double-Blind, Multicenter Phase â…¡ Trial.
    Clin Cancer Res. 2023 Aug 18:CCR-22-3406. doi: 10.1158/1078-0432.CCR-22-3406.
    PubMed     Abstract available


  128. NIU Z, Sun P, Liu H, Wei P, et al
    Functional Genetic Variants in TGFbeta1 and TGFbetaR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma.
    Clin Cancer Res. 2023;29:3081-3091.
    PubMed     Abstract available


  129. DAI Y, Wang Z, Xia Y, Li J, et al
    Integrative Single-Cell and Bulk Transcriptomes Analyses Identify Intrinsic HNSCC Subtypes with Distinct Prognoses and Therapeutic Vulnerabilities.
    Clin Cancer Res. 2023;29:2845-2858.
    PubMed     Abstract available


    June 2023
  130. HU H, Ng TSC, Kang M, Scott E, et al
    Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response.
    Clin Cancer Res. 2023 Jun 8:CCR-22-2976. doi: 10.1158/1078-0432.CCR-22-2976.
    PubMed     Abstract available


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