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Bacterial Infections and Mycoses

Free Subscription Articles published in J Med Chem Retrieve available abstracts of 68 articles: HTML format

Single Articles

October 2025
1. KOVAR O, Kufa M, Finger V, Soukup O, et al
   Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies.
   J Med Chem. 2025 Oct 7. doi: 10.1021/acs.jmedchem.5c01100.
   PubMed     Abstract available
   
   
   September 2025
2. LEE JK, Lee CY, Son M, Kim B, et al
   A Novel Peptide Antibiotic Targeting Gram-Negative Infections Designed from Mycobacterium tuberculosis Adenylate Kinase.
   J Med Chem. 2025 Sep 4. doi: 10.1021/acs.jmedchem.5c01412.
   PubMed     Abstract available
   
   
   August 2025
3. HOLLY KJ, Tharra PR, Abutaleb NS, Nocentini A, et al
   Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia.
   J Med Chem. 2025 Aug 29. doi: 10.1021/acs.jmedchem.5c01584.
   PubMed     Abstract available
   
   
   
4. SONKER H, Dewan S, Chaudhary K, Agrahari B, et al
   Water-Soluble Ruthenium(II) p-Cymene Complexes Mitigating Intracellular S. aureus Infection: Bridging Antibacterial Defense and Anticancer Therapy.
   J Med Chem. 2025;68:17897-17916.
   PubMed     Abstract available
   
   
   
5. DUAN M, Huang X, Qiu C, Sun L, et al
   Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcu
   J Med Chem. 2025 Aug 15. doi: 10.1021/acs.jmedchem.5c00037.
   PubMed     Abstract available
   
   
   
6. NI D, Liu G
   Iron Uptake Systems: Chemical Tools for Advancing Infectious Disease Treatment and Diagnosis.
   J Med Chem. 2025;68:15285-15338.
   PubMed     Abstract available
   
   
   
7. DAVIS SH, Mathieson M, Buchanan KI, Dawson A, et al
   Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.
   J Med Chem. 2025 Aug 1. doi: 10.1021/acs.jmedchem.5c01331.
   PubMed     Abstract available
   
   
   July 2025
8. AMBROSIO FA, Marchese E, Listro R, Linciano P, et al
   In Silico-Guided Discovery and In Vitro Evaluation of Natural Sortase A Inhibitors to Fight Multidrug-Resistant Staphylococcus aureus.
   J Med Chem. 2025 Jul 30. doi: 10.1021/acs.jmedchem.5c01009.
   PubMed     Abstract available
   
   
   
9. LONG HZ, Tang W, Huang MY, Yang GB, et al
   Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3-Hydroxypyridin-4(1H)-ones with N-Phenylamide QS Inhibitors.
   J Med Chem. 2025;68:14756-14781.
   PubMed     Abstract available
   
   
   
10. LUO J, Yin J, Xie G, Li Z, et al
    Discovery of SaClpP-Selective Imipridone Derivatives as Novel Antistaphylococcal Agents.
    J Med Chem. 2025;68:14555-14568.
    PubMed     Abstract available
    
    
    
11. KAVANAGH ME, McLean KJ, Gilbert SH, Amadi CN, et al
    Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.
    J Med Chem. 2025 Jul 13. doi: 10.1021/acs.jmedchem.5c00478.
    PubMed     Abstract available
    
    
    
12. SINGH M, Boomgaren M, Bakht P, Ihle P, et al
    Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to beta-Lactam Antibiotics.
    J Med Chem. 2025;68:13421-13435.
    PubMed     Abstract available
    
    
    June 2025
13. CHEN Y, Li Y, Nahar KS, Hasan MM, et al
    New Generation Modified Azole Antifungals against Multidrug-Resistant Candida auris.
    J Med Chem. 2025 Jun 23. doi: 10.1021/acs.jmedchem.5c01253.
    PubMed     Abstract available
    
    
    
14. LIN J, Yang W, Xin J, Cao H, et al
    Lead Optimization and Target Identification of Carboline Antifungal Agents.
    J Med Chem. 2025;68:11502-11515.
    PubMed     Abstract available
    
    
    
15. NEGI A, Perveen S, Kour H, Singh PP, et al
    Keeping Up with the Q's: Mechanistic Insights and Validation of Quinoline and Quinazoline Scaffolds as Potent Drugs against Tuberculosis.
    J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.4c02568.
    PubMed     Abstract available
    
    
    May 2025
16. SONKER H, Chaudhary K, Agrahari B, Dewan S, et al
    De Novo 3-(Phenylcarbamoyl) Benzoate Analogues: Efficacy against Multidrug-Resistant S. aureus and Elucidation of the Biodistribution Profile.
    J Med Chem. 2025;68:10329-10345.
    PubMed     Abstract available
    
    
    
17. PUJARI AK, Kirar S, Gogde K, Rawat K, et al
    Designing Lignin-Based Nanophotocomposites as Reactive Oxygen Species Generators for Inactivating Candida Strains.
    J Med Chem. 2025 May 12. doi: 10.1021/acs.jmedchem.5c00482.
    PubMed     Abstract available
    
    
    
18. ANTONINI G, Fares M, Hauck D, Mala P, et al
    Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa-Burkholderia cenocepacia Infections: A Biophysical Study.
    J Med Chem. 2025;68:9681-9693.
    PubMed     Abstract available
    
    
    
19. TIAN L, Wang T, Luan L, Meng Z, et al
    Terminally Symmetric beta-Turn Peptides for Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:9341-9356.
    PubMed     Abstract available
    
    
    
20. HEIDTMANN CV, Fisker CD, Logstrup S, Eriksen PG, et al
    Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins.
    J Med Chem. 2025;68:9479-9500.
    PubMed     Abstract available
    
    
    April 2025
21. XIE Y, Wang X, Chang T, Chen Z, et al
    Novel Aryl Sulfonium Modification on Vancomycin to Tackle MRSA and VRE In Vitro and In Vivo through Dual Enhanced Cell-Wall and Membrane Inhibition.
    J Med Chem. 2025;68:8310-8329.
    PubMed     Abstract available
    
    
    
22. LIANG T, Tu J, He Q, Zou P, et al
    Discovery of New Pyrazolone Carbothioamide Derivatives as Potent Antifungal Agents for the Treatment of Candidiasis and Cryptococcosis.
    J Med Chem. 2025;68:8439-8454.
    PubMed     Abstract available
    
    
    
23. XU T, Xue Z, Li X, Zhang M, et al
    Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties.
    J Med Chem. 2025;68:7459-7475.
    PubMed     Abstract available
    
    
    
24. LIU K, Liu Y, Wang Q, Nazare M, et al
    PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections.
    J Med Chem. 2025;68:7827-7838.
    PubMed     Abstract available
    
    
    March 2025
25. ZHANG ZM, Zhao SY, Liu WQ, Wu X, et al
    Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections.
    J Med Chem. 2025;68:6210-6232.
    PubMed     Abstract available
    
    
    
26. HE Y, Su J, Li M, Fareed MS, et al
    Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations.
    J Med Chem. 2025;68:5699-5718.
    PubMed     Abstract available
    
    
    
27. CARDOSO J, Pinto E, Sousa E, Resende DISP, et al
    Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds.
    J Med Chem. 2025;68:5006-5023.
    PubMed     Abstract available
    
    
    
28. SHARMA P, Jiang Q, Li SG, Ocke E, et al
    Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis.
    J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156.
    PubMed     Abstract available
    
    
    
29. CAZZANIGA G, Mori M, Griego A, Scarpa E, et al
    Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy.
    J Med Chem. 2025 Mar 3. doi: 10.1021/acs.jmedchem.4c02386.
    PubMed     Abstract available
    
    
    February 2025
30. ZIMMERMANN T, Feng J, Fischer S, de Campos LJ, et al
    Structural Optimization of Covalent Inhibitors for Deubiquitinase ChlaDUB1 of Chlamydia trachomatis as Antibiotic Agents.
    J Med Chem. 2025 Feb 28. doi: 10.1021/acs.jmedchem.4c02464.
    PubMed     Abstract available
    
    
    
31. XU L, Wang Y, Hu S, Pei Y, et al
    Discovery of Metabolic Reprogramming 2-Quinolones as Effective Antimicrobials for MRSA-Infected Wound Therapy.
    J Med Chem. 2025;68:3004-3019.
    PubMed     Abstract available
    
    
    January 2025
32. LI G, Chen W, Guan H, Lai Z, et al
    Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm.
    J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02598.
    PubMed     Abstract available
    
    
    
33. ZHANG M, Yang W, Liu N, Tu J, et al
    Lanosterol 14alpha-Demethylase (CYP51)/Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis.
    J Med Chem. 2025;68:1668-1681.
    PubMed     Abstract available
    
    
    
34. YAN X, Yang C, Li B, Bian Y, et al
    Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections.
    J Med Chem. 2025;68:1397-1416.
    PubMed     Abstract available
    
    
    
35. ZHANG T, Wu W, Zhao Y, Ding Z, et al
    Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
    J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02562.
    PubMed     Abstract available
    
    
    December 2024
36. LIU X, Wang D, Wei X, Yang D, et al
    Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection.
    J Med Chem. 2024;67:22145-22167.
    PubMed     Abstract available
    
    
    
37. DA SILVA FF, Paz JD, Rambo RS, Goncalves GA, et al
    Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
    J Med Chem. 2024;67:21781-21794.
    PubMed     Abstract available
    
    
    
38. RANI N, Rajmani RS, Surolia A
    Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis.
    J Med Chem. 2024 Dec 18. doi: 10.1021/acs.jmedchem.4c01844.
    PubMed     Abstract available
    
    
    
39. LIU K, Xia J, Li Y, Li BB, et al
    Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents.
    J Med Chem. 2024;67:21030-21048.
    PubMed     Abstract available
    
    
    
40. BERIDA T, Lindsley CW
    Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease.
    J Med Chem. 2024 Dec 9. doi: 10.1021/acs.jmedchem.4c02876.
    PubMed    
    
    
    November 2024
41. LIU JJ, Liu J, Huang YS, Chen WM, et al
    Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.
    J Med Chem. 2024;67:18911-18929.
    PubMed     Abstract available
    
    
    October 2024
42. YAN D, Kong H, Qu Y, Li R, et al
    Development of Phloroglucinol-Linked Tris-Quaternary Ammonium Salt Antimicrobial Peptide Mimics with Low Cytotoxicity and Broad-Spectrum Antibacterial Activity.
    J Med Chem. 2024;67:18576-18592.
    PubMed     Abstract available
    
    
    September 2024
43. MIAO ZY, Zhang XY, Long HZ, Lin J, et al
    Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.
    J Med Chem. 2024;67:16835-16857.
    PubMed     Abstract available
    
    
    
44. MAJI S, Akhtar S, Halder S, Chatterjee I, et al
    Corannulene Amino Acid-Derived Water-Soluble Amphiphilic Buckybowls as Broad-Spectrum Membrane Targeting Antibacterial Agents.
    J Med Chem. 2024;67:15041-15060.
    PubMed     Abstract available
    
    
    
45. SKUDLAREK JW, Cooke AJ, Mitchell HJ, Babaoglu K, et al
    Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
    J Med Chem. 2024;67:15620-15675.
    PubMed     Abstract available
    
    
    
46. YOUSE MS, Abutaleb NS, Nocentini A, S Abdelsattar A, et al
    Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae.
    J Med Chem. 2024;67:15537-15556.
    PubMed     Abstract available
    
    
    
47. YANG R, Cui L, Xu S, Zhong Y, et al
    Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Sep 11. doi: 10.1021/acs.jmedchem.4c01860.
    PubMed     Abstract available
    
    
    August 2024
48. LI K, Tolentino Collado J, Marden JA, Pollard AC, et al
    Biological Evaluation of d-[(18)F]Fluoroalanine and d-[(18)F]Fluoroalanine-d(3) as Positron Emission Tomography Imaging Tracers for Bacterial Infection.
    J Med Chem. 2024;67:13975-13984.
    PubMed     Abstract available
    
    
    
49. CHARRIA-GIRON E, Zeng H, Gorelik TE, Pahl A, et al
    Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis.
    J Med Chem. 2024 Aug 14. doi: 10.1021/acs.jmedchem.4c00585.
    PubMed     Abstract available
    
    
    
50. PELLICCIA S, Russomanno P, Barone S, Mateu B, et al
    A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
    J Med Chem. 2024 Aug 8. doi: 10.1021/acs.jmedchem.4c01109.
    PubMed     Abstract available
    
    
    
51. YAN Z, Li Q, Li X, Wang H, et al
    Discovery of Novel alpha,beta-Unsaturated Amide Derivatives as Candidate Antifungals to Overcome Fungal Resistance.
    J Med Chem. 2024;67:12601-12617.
    PubMed     Abstract available
    
    
    July 2024
52. YU Z, Liang YC, Berton S, Liu L, et al
    Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy.
    J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
    PubMed     Abstract available
    
    
    June 2024
53. ZHANG L, Yang J, Xu X, Zhang J, et al
    Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.
    J Med Chem. 2024;67:10096-10134.
    PubMed     Abstract available
    
    
    
54. MULAR A, Hubmann I, Petrik M, Bendova K, et al
    Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity.
    J Med Chem. 2024 Jun 22. doi: 10.1021/acs.jmedchem.4c00887.
    PubMed     Abstract available
    
    
    
55. ZIMMERMANN T, Feng J, de Campos LJ, Knight LA, et al
    Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis.
    J Med Chem. 2024 Jun 19. doi: 10.1021/acs.jmedchem.4c00230.
    PubMed     Abstract available
    
    
    
56. RUEEDI G, Panchaud P, Friedli A, Specklin JL, et al
    Discovery and Structure-Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection.
    J Med Chem. 2024;67:9465-9484.
    PubMed     Abstract available
    
    
    May 2024
57. YU S, He YQ, Liu Y, Ji S, et al
    Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment.
    J Med Chem. 2024;67:8420-8444.
    PubMed     Abstract available
    
    
    
58. WANG X, Jin X, Zhao F, Xu Z, et al
    Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections.
    J Med Chem. 2024 May 19. doi: 10.1021/acs.jmedchem.4c00470.
    PubMed     Abstract available
    
    
    
59. HE Y, Ruan S, Liang G, Hao J, et al
    A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality.
    J Med Chem. 2024;67:7487-7503.
    PubMed     Abstract available
    
    
    April 2024
60. NI T, Hao Y, Ding Z, Chi X, et al
    Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum.
    J Med Chem. 2024;67:6238-6252.
    PubMed     Abstract available
    
    
    March 2024
61. YANG W, Liu R, Li Z, Tu J, et al
    Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis.
    J Med Chem. 2024;67:4726-4738.
    PubMed     Abstract available
    
    
    
62. MUSZALSKA-KOLOS I, Dwiecki PM
    Searching for Conjugates as New Structures for Antifungal Therapies.
    J Med Chem. 2024;67:4298-4321.
    PubMed     Abstract available
    
    
    
63. FRANCO AR, Sadones O, Romerio A, Artusa V, et al
    Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.
    J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02215.
    PubMed     Abstract available
    
    
    
64. XU T, Yan X, Kang A, Yang L, et al
    Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Mar 16. doi: 10.1021/acs.jmedchem.4c00436.
    PubMed     Abstract available
    
    
    
65. HEIDTMANN CV, Fejer AR, Staerk K, Pedersen M, et al
    Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
    J Med Chem. 2024;67:3692-3710.
    PubMed     Abstract available
    
    
    
66. XIE F, Hao Y, Liu Y, Bao J, et al
    From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo.
    J Med Chem. 2024;67:4007-4025.
    PubMed     Abstract available
    
    
    
67. HUANG Z, Gou X, Hang X, Shi T, et al
    Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus.
    J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02355.
    PubMed     Abstract available
    
    
    February 2024
68. MADDIRALA AR, Pinkner JS, Tamadonfar K, Sanick D, et al
    Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
    J Med Chem. 2024 Feb 3. doi: 10.1021/acs.jmedchem.3c02128.
    PubMed     Abstract available
    
    

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