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Articles published in J Med Chem

Retrieve available abstracts of 42 articles:
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Single Articles


    May 2018
  1. CHIKHALE RV, Barmade MA, Murumkar PR, Yadav MR, et al
    An Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis.
    J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.8b00281.
    PubMed     Text format     Abstract available


  2. CHACKO S, Boshoff HIM, Singh V, Ferraris DM, et al
    Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.
    J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.7b01839.
    PubMed     Text format     Abstract available


    March 2018
  3. TRAPERO A, Pacitto A, Singh V, Sabbah M, et al
    Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
    J Med Chem. 2018 Mar 23. doi: 10.1021/acs.jmedchem.7b01622.
    PubMed     Text format     Abstract available


  4. SONG L, Merceron R, Gracia B, Quintana AL, et al
    Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors.
    J Med Chem. 2018 Mar 6. doi: 10.1021/acs.jmedchem.7b01570.
    PubMed     Text format     Abstract available


    February 2018
  5. CAI S, Qiao X, Feng L, Shi N, et al
    Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality.
    J Med Chem. 2018 Feb 21. doi: 10.1021/acs.jmedchem.8b00036.
    PubMed     Text format     Abstract available


    January 2018
  6. PARMAR A, Lakshminarayanan R, Iyer A, Mayandi V, et al
    Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE) in vitro and in vivo.
    J Med Chem. 2018 Jan 24. doi: 10.1021/acs.jmedchem.7b01634.
    PubMed     Text format     Abstract available


  7. ZHANG W, Lun S, Wang SH, Jiang X, et al
    Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Jan 12. doi: 10.1021/acs.jmedchem.7b01319.
    PubMed     Text format     Abstract available


    December 2017
  8. GUAN D, Chen F, Xiong L, Tang F, et al
    Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
    J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01345.
    PubMed     Text format     Abstract available


  9. CAMERON AJ, Edwards PJB, Harjes E, Sarojini V, et al
    Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
    J Med Chem. 2017;60:9565-9574.
    PubMed     Text format     Abstract available


  10. MOON SH, Zhang X, Zheng G, Meeker DG, et al
    Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin.
    J Med Chem. 2017;60:9630-9640.
    PubMed     Text format     Abstract available


  11. CHOI H, Ham SY, Cha E, Shin Y, et al
    Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents.
    J Med Chem. 2017;60:9821-9837.
    PubMed     Text format     Abstract available


    October 2017
  12. GOOD JAD, Kulen M, Silver J, Krishnan KS, et al
    Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity.
    J Med Chem. 2017 Oct 20. doi: 10.1021/acs.jmedchem.7b00716.
    PubMed     Text format     Abstract available


    September 2017
  13. LI X, Hernandez V, Rock FL, Choi W, et al
    Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
    J Med Chem. 2017 Sep 27. doi: 10.1021/acs.jmedchem.7b00631.
    PubMed     Text format     Abstract available


  14. BUCHIERI MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, et al
    Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.
    J Med Chem. 2017;60:7425-7433.
    PubMed     Text format     Abstract available


  15. CHEN AY, Thomas PW, Stewart AC, Bergstrom A, et al
    Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-beta-lactamase-1.
    J Med Chem. 2017;60:7267-7283.
    PubMed     Text format     Abstract available


  16. ABDEL MONAIM SAH, Ramchuran EJ, El-Faham A, Albericio F, et al
    Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
    J Med Chem. 2017;60:7476-7482.
    PubMed     Text format     Abstract available


  17. NI S, Wei H, Li B, Chen F, et al
    Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant and Vancomycin-Intermediate Staphylococcus aureus Infections in vivo.
    J Med Chem. 2017 Sep 7. doi: 10.1021/acs.jmedchem.7b00949.
    PubMed     Text format     Abstract available


    July 2017
  18. KOZIKOWSKI AP, Onajole OK, Stec J, Dupont C, et al
    Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections.
    J Med Chem. 2017;60:5876-5888.
    PubMed     Text format     Abstract available


    June 2017
  19. PIIZZI G, Parker DT, Peng Y, Dobler M, et al
    Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
    J Med Chem. 2017;60:5002-5014.
    PubMed     Text format     Abstract available


  20. LIN S, Koh JJ, Aung TT, Sin WLW, et al
    Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2017 Jun 21. doi: 10.1021/acs.jmedchem.7b00380.
    PubMed     Text format     Abstract available


  21. LIU F, Dawadi S, Maize KM, Dai R, et al
    Structure-Based Optimization of Pyridoxal 5'-Phosphate (PLP)-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2017 Jun 8. doi: 10.1021/acs.jmedchem.7b00189.
    PubMed     Text format     Abstract available


    May 2017
  22. PANCHAUD P, Bruyere T, Blumstein AC, Bur D, et al
    Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
    J Med Chem. 2017;60:3755-3775.
    PubMed     Text format     Abstract available


  23. BHOWMICK M, Tokmina-Roszyk D, Onwuha-Ekpete L, Harmon K, et al
    Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.
    J Med Chem. 2017;60:3814-3827.
    PubMed     Text format     Abstract available


  24. MAYER K, Eris D, Schwardt O, Sager CP, et al
    Urinary Tract Infection - Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?
    J Med Chem. 2017 May 4. doi: 10.1021/acs.jmedchem.7b00342.
    PubMed     Text format     Abstract available


    April 2017
  25. HAGRAS M, Mohammad H, Mandour MS, Hegazy YA, et al
    Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).
    J Med Chem. 2017 Apr 24. doi: 10.1021/acs.jmedchem.7b00392.
    PubMed     Text format     Abstract available


  26. SIRICILLA S, Mitachi K, Yang J, Eslamimehr S, et al
    A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.
    J Med Chem. 2017;60:2869-2878.
    PubMed     Text format     Abstract available


  27. YANG T, Moreira W, Nyantakyi SA, Chen H, et al
    Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties.
    J Med Chem. 2017;60:2745-2763.
    PubMed     Text format     Abstract available


  28. TAN L, Tao Y, Wang T, Zou F, et al
    Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
    J Med Chem. 2017;60:2669-2684.
    PubMed     Text format     Abstract available


    March 2017
  29. DENG Y, Sun C, Hunt DK, Fyfe C, et al
    Heterocyclyl Tetracyclines. 1. 7-Trifluoromethyl-8-Pyrrolidinyltetracyclines: Potent, Broad Spectrum Antibacterial Agents with Enhanced Activity against Pseudomonas aeruginosa.
    J Med Chem. 2017;60:2498-2512.
    PubMed     Text format     Abstract available


  30. DOU X, Zhu X, Wang J, Dong N, et al
    Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
    J Med Chem. 2017;60:2257-2270.
    PubMed     Text format     Abstract available


  31. HONG WD, Gibbons PD, Leung SC, Amewu R, et al
    Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.
    J Med Chem. 2017 Mar 17. doi: 10.1021/acs.jmedchem.6b01718.
    PubMed     Text format     Abstract available


  32. MOHAMMAD H, Younis W, Chen L, Peters CE, et al
    Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci.
    J Med Chem. 2017 Mar 1. doi: 10.1021/acs.jmedchem.6b01780.
    PubMed     Text format     Abstract available


    February 2017
  33. TOLEDANO-MAGANA Y, Garcia-Ramos JC, Torres-Gutierrez C, Vazquez-Gasser C, et al
    Water-Soluble Ruthenium (II) Chiral Heteroleptic Complexes with Amoebicidal in Vitro and in Vivo Activity.
    J Med Chem. 2017;60:899-912.
    PubMed     Text format     Abstract available


  34. ASTOLFI A, Felicetti T, Iraci N, Manfroni G, et al
    Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.
    J Med Chem. 2017 Feb 8. doi: 10.1021/acs.jmedchem.6b01439.
    PubMed     Text format     Abstract available


    December 2016
  35. STULAR T, Lesnik S, Rozman K, Schink J, et al
    Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


  36. GARZAN A, Willby MJ, Green KD, Gajadeera CS, et al
    Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.
    J Med Chem. 2016;59:10619-10628.
    PubMed     Text format     Abstract available


    September 2016
  37. GORDON CP, Olson SD, Lister JL, Kavanaugh JS, et al
    Truncated auto-inducing peptides as antagonists of Staphylococcus lugdunensis quorum sensing.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


    July 2016
  38. BRUNNER K, Maric S, Reshma RS, Almqvist H, et al
    Inhibitors of the cysteine synthase CysM with antibacterial potency against dormant Mycobacterium tuberculosis.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


    June 2016
  39. PITTA E, Rogacki MK, Balabon O, Huss S, et al
    Searching for new leads for Tuberculosis: Design, synthesis and biological evaluation of novel 2-quinolin-4-yloxyacetamides.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


  40. BARANOWSKI C, Rubin EJ
    Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


  41. STEC J, Onajole OK, Lun S, Guo H, et al
    Indole-2-carboxamide-Based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


    May 2016
  42. YU M, Nagalingam G, Ellis S, Martinez E, et al
    Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


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