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Bacterial Infections and Mycoses

Free Subscription Articles published in J Med Chem Retrieve available abstracts of 103 articles: HTML format

Single Articles

August 2026
1. MARTIN DP, Teng M, Nammalwar B, Perez C, et al
   Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.
   J Med Chem. 2026;69:18692-18704.
   PubMed     Abstract available
   
   
   
2. ZHANG T, Zhao J, Praveen P, Parisi K, et al
   Unveiling the Potential of Magainin Derivatives against Candida Species.
   J Med Chem. 2026;69:18992-19004.
   PubMed     Abstract available
   
   
   July 2026
3. LUO Z, Sun Y, Gao Z, Liu N, et al
   Rational Design and Discovery of CZx-243: A Highly Stable and Orally Bioavailable Triazole CYP51 Inhibitor for the Treatment of Invasive Fungal Infections.
   J Med Chem. 2026;69:17189-17210.
   PubMed     Abstract available
   
   
   
4. LI S, Hao W, Ye Z, Mo G, et al
   Screening of Cell-Penetrating Peptides To Enhance the Therapeutic Efficacy of alpha-Helical Antimicrobial Peptides against Intracellular Bacterial Infections.
   J Med Chem. 2026;69:16455-16475.
   PubMed     Abstract available
   
   
   
5. YU Z, Li Y, Liu J, Xu Q, et al
   Novel High-Efficacy Antimicrobial Peptides Derived from Myxinidin and their Therapeutic Efficacy in Bacterial Pneumonia.
   J Med Chem. 2026;69:16997-17024.
   PubMed     Abstract available
   
   
   
6. ZHAO X, Liu H, Lin X, Fontaine J, et al
   Design of Right-Handed D-Sulfonyl-gamma-AApeptides with Broad-Spectrum Antimicrobial Activity.
   J Med Chem. 2026;69:16911-16925.
   PubMed     Abstract available
   
   
   
7. KIM YG, O'Driscoll M, Horgan C, Boya BR, et al
   Lauric Acid- and BDSF-Derived N-Acyl Sulfonamides as Potent Antibiofilm and Antivirulence Agents against Staphylococcus aureus.
   J Med Chem. 2026 Jul 9. doi: 10.1021/acs.jmedchem.6c01485.
   PubMed     Abstract available
   
   
   
8. ZHANG S, Liu Z, Zhang N, Wu S, et al
   Discovery of Guanidyl-Stapled Aurein1.2 Peptides with Potent In Vivo Antimicrobial Activities.
   J Med Chem. 2026;69:15558-15569.
   PubMed     Abstract available
   
   
   
9. TAMHAEV R, Recchia D, Zahorszka M, Stelitano G, et al
   Rational Design of Diaryl Ether-Based Dual Inhibitors Targeting Successive Essential Enzymes HadAB and InhA in Mycobacterium tuberculosis.
   J Med Chem. 2026 Jul 7. doi: 10.1021/acs.jmedchem.6c01302.
   PubMed     Abstract available
   
   
   June 2026
10. SUN Y, Li R, Yin K, Zhang J, et al
    Computer-Aided Rational Modification of Hst 5 Based on Ssa1/2 and the Antifungal Activity of the Derivatives against Candida spp.
    J Med Chem. 2026 Jun 22. doi: 10.1021/acs.jmedchem.5c03652.
    PubMed     Abstract available
    
    
    
11. ZHAO Z, Zhang M, Yang K, Liao X, et al
    Synthesis of Novel Isoxazoline Derivatives with Selective Inhibition of the Drug Efflux Pump Mdr1 to Reverse Drug Resistance of Candida albicans In Vitro and In Vivo.
    J Med Chem. 2026 Jun 16. doi: 10.1021/acs.jmedchem.5c03625.
    PubMed     Abstract available
    
    
    
12. DIAMANTI E, Cremers AJH, Li Y, Exapicheidou I, et al
    Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae.
    J Med Chem. 2026 Jun 12. doi: 10.1021/acs.jmedchem.5c03638.
    PubMed     Abstract available
    
    
    
13. MERRICK CE, Chakraborty M, Van Wazer JM, O'Connor LD, et al
    A Siderophore-Antibiotic Heterodimer Imaging Agent Enables In Vivo PET Imaging of S. aureus Infections.
    J Med Chem. 2026;69:13652-13669.
    PubMed     Abstract available
    
    
    
14. URBANOWICZ KA, Marek-Urban PH, Wrochna K, Rogalska M, et al
    C-BODIPY Dyads Based on Fused-Ring Organoboron Scaffolds for Efficient Photodynamic Therapy Targeting Candida albicans Yeast and Biofilms.
    J Med Chem. 2026 Jun 1. doi: 10.1021/acs.jmedchem.6c00280.
    PubMed     Abstract available
    
    
    May 2026
15. THARRA PR, Youse MS, Abutaleb NS, Abdelsattar AS, et al
    Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with In Vivo Efficacy against Drug-Resistant Neisseria gonorrhoeae.
    J Med Chem. 2026;69:12183-12204.
    PubMed     Abstract available
    
    
    
16. ZOU P, Tu J, Liu R, He Q, et al
    Discovery of New Pyrazolone Derivatives for Treating Invasive Fungal Infections by Iron Homeostasis Disruption.
    J Med Chem. 2026;69:11382-11396.
    PubMed     Abstract available
    
    
    
17. ZHOU YB, Wu X, Li YJ, Zhao SY, et al
    Discovery of Catechol-Benzothiazole Conjugates as Antibacterial Synergists against Pseudomonas aeruginosa by Inhibiting Biofilm Formation.
    J Med Chem. 2026;69:11258-11291.
    PubMed     Abstract available
    
    
    
18. SHAO H, Wu X, Cheng S, Wang B, et al
    Rhodanine-Inspired Development of Dual-Action Mycobacterium tuberculosis Protein Tyrosine Phosphatase B Inhibitors.
    J Med Chem. 2026 May 6. doi: 10.1021/acs.jmedchem.6c00103.
    PubMed     Abstract available
    
    
    April 2026
19. MOSALLAM N, O'Neill PM, Lisauskaite M, Woodley CM, et al
    Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of Mycobacterium tuberculosis Displaying Enhanced Metabolic Stability.
    J Med Chem. 2026 Apr 23. doi: 10.1021/acs.jmedchem.5c03274.
    PubMed     Abstract available
    
    
    
20. LIU Q, Engelhart CA, Wallach JB, Ge P, et al
    Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2026 Apr 22. doi: 10.1021/acs.jmedchem.5c03325.
    PubMed     Abstract available
    
    
    March 2026
21. XU T, Wang T, Hu L, Han N, et al
    Identification of Rutaecarpine-Pyridinium Quaternary Ammonium Conjugates Exhibiting Dual Mechanisms of Membrane-Targeting and DNA Topo I Inhibition as Potent Antimicrobials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2026 Mar 30. doi: 10.1021/acs.jmedchem.5c03478.
    PubMed     Abstract available
    
    
    
22. KANG J, Lee D, Kim MK, Ahn JH, et al
    New Multitarget Inhibitor Potentiates Antimicrobial Activity of Aztreonam against Metallo-beta-lactamase-Producing Pseudomonas aeruginosa Including IMP-Types.
    J Med Chem. 2026;69:5560-5574.
    PubMed     Abstract available
    
    
    February 2026
23. VALDERRAMA K, Horlacher O, Publicola G, Eisenring P, et al
    Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach.
    J Med Chem. 2026;69:2496-2508.
    PubMed     Abstract available
    
    
    
24. XUE R, Luo C, Dou L, Yu X, et al
    Design and Synthesis of Membrane-Targeting Poly-Ruthenium Complexes Containing Quaternary Ammonium Cations with Potential Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2026 Feb 4. doi: 10.1021/acs.jmedchem.5c02644.
    PubMed     Abstract available
    
    
    January 2026
25. WEN R, Xing G, Li H, Yang J, et al
    Design, Synthesis, and Biological Evaluation of Acid-Responsive Bifunctional Molecules with Dual Anti-Helicobacter pylori and Acid Suppression Activities.
    J Med Chem. 2026;69:1342-1357.
    PubMed     Abstract available
    
    
    
26. ZHANG W, Chen J, Fang M, Song M, et al
    Discovery and Structural Optimization of Spirodioxynaphthalene-Based Mdr1 Efflux Pump Inhibitor to Combat Azole Resistance in Candida albicans.
    J Med Chem. 2026 Jan 14. doi: 10.1021/acs.jmedchem.5c03455.
    PubMed     Abstract available
    
    
    
27. SINGH S, Ng PS, Lakshmanan U, Mathiyazakan V, et al
    A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis.
    J Med Chem. 2026 Jan 13. doi: 10.1021/acs.jmedchem.5c01616.
    PubMed     Abstract available
    
    
    December 2025
28. YE J, Kan CH, Liu J, Tsang TF, et al
    Dithioether Inhibitors of Bacterial RNA Polymerase-Sigma Factor Interactions Exhibit In Vivo Efficacy against MRSA.
    J Med Chem. 2025;68:25352-25374.
    PubMed     Abstract available
    
    
    
29. KUMAR TA, Birua S, Mallojjala SC, Mukherjee P, et al
    A Mycobacteria-Specific Prodrug to Overcome Phenotypic AMR in Mycobacterium tuberculosis.
    J Med Chem. 2025 Dec 1. doi: 10.1021/acs.jmedchem.5c01848.
    PubMed     Abstract available
    
    
    November 2025
30. TAN YM, Wei YJ, Ahmad N, Zhang SL, et al
    Identification of Novel Benzopyridonyl Cyanovinylpyrimidines as Potential Broad-Spectrum Antibacterial Members.
    J Med Chem. 2025;68:24232-24259.
    PubMed     Abstract available
    
    
    
31. JIANG S, Zhang W, Tian L, Zeng C, et al
    Rational Leucine-Centric Design Confers Enhanced Proteolytic Stability and Reduced Toxicity of Antimicrobial Peptides against Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:23006-23023.
    PubMed     Abstract available
    
    
    
32. CHAUDHARY K, Agrahari B, Sonker H, Dewan S, et al
    Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii.
    J Med Chem. 2025;68:22264-22287.
    PubMed     Abstract available
    
    
    
33. DOMINGUEZ-CISNEROS H, Konai MM, Kim C, Rana N, et al
    Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of Streptococcus pneumoniae Penicillin-Binding Protein 2x.
    J Med Chem. 2025 Nov 10. doi: 10.1021/acs.jmedchem.5c02273.
    PubMed     Abstract available
    
    
    October 2025
34. PODDAR SK, Dey K, Zheng G
    Harnessing Chimeric Degrader Technologies for Antimicrobial Innovation.
    J Med Chem. 2025;68:20930-20963.
    PubMed     Abstract available
    
    
    
35. KOVAR O, Kufa M, Finger V, Soukup O, et al
    Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies.
    J Med Chem. 2025 Oct 7. doi: 10.1021/acs.jmedchem.5c01100.
    PubMed     Abstract available
    
    
    September 2025
36. LEE JK, Lee CY, Son M, Kim B, et al
    A Novel Peptide Antibiotic Targeting Gram-Negative Infections Designed from Mycobacterium tuberculosis Adenylate Kinase.
    J Med Chem. 2025 Sep 4. doi: 10.1021/acs.jmedchem.5c01412.
    PubMed     Abstract available
    
    
    August 2025
37. HOLLY KJ, Tharra PR, Abutaleb NS, Nocentini A, et al
    Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia.
    J Med Chem. 2025 Aug 29. doi: 10.1021/acs.jmedchem.5c01584.
    PubMed     Abstract available
    
    
    
38. SONKER H, Dewan S, Chaudhary K, Agrahari B, et al
    Water-Soluble Ruthenium(II) p-Cymene Complexes Mitigating Intracellular S. aureus Infection: Bridging Antibacterial Defense and Anticancer Therapy.
    J Med Chem. 2025;68:17897-17916.
    PubMed     Abstract available
    
    
    
39. DUAN M, Huang X, Qiu C, Sun L, et al
    Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcu
    J Med Chem. 2025 Aug 15. doi: 10.1021/acs.jmedchem.5c00037.
    PubMed     Abstract available
    
    
    
40. NI D, Liu G
    Iron Uptake Systems: Chemical Tools for Advancing Infectious Disease Treatment and Diagnosis.
    J Med Chem. 2025;68:15285-15338.
    PubMed     Abstract available
    
    
    
41. DAVIS SH, Mathieson M, Buchanan KI, Dawson A, et al
    Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.
    J Med Chem. 2025 Aug 1. doi: 10.1021/acs.jmedchem.5c01331.
    PubMed     Abstract available
    
    
    July 2025
42. AMBROSIO FA, Marchese E, Listro R, Linciano P, et al
    In Silico-Guided Discovery and In Vitro Evaluation of Natural Sortase A Inhibitors to Fight Multidrug-Resistant Staphylococcus aureus.
    J Med Chem. 2025 Jul 30. doi: 10.1021/acs.jmedchem.5c01009.
    PubMed     Abstract available
    
    
    
43. LONG HZ, Tang W, Huang MY, Yang GB, et al
    Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3-Hydroxypyridin-4(1H)-ones with N-Phenylamide QS Inhibitors.
    J Med Chem. 2025;68:14756-14781.
    PubMed     Abstract available
    
    
    
44. LUO J, Yin J, Xie G, Li Z, et al
    Discovery of SaClpP-Selective Imipridone Derivatives as Novel Antistaphylococcal Agents.
    J Med Chem. 2025;68:14555-14568.
    PubMed     Abstract available
    
    
    
45. KAVANAGH ME, McLean KJ, Gilbert SH, Amadi CN, et al
    Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.
    J Med Chem. 2025 Jul 13. doi: 10.1021/acs.jmedchem.5c00478.
    PubMed     Abstract available
    
    
    
46. SINGH M, Boomgaren M, Bakht P, Ihle P, et al
    Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to beta-Lactam Antibiotics.
    J Med Chem. 2025;68:13421-13435.
    PubMed     Abstract available
    
    
    June 2025
47. CHEN Y, Li Y, Nahar KS, Hasan MM, et al
    New Generation Modified Azole Antifungals against Multidrug-Resistant Candida auris.
    J Med Chem. 2025 Jun 23. doi: 10.1021/acs.jmedchem.5c01253.
    PubMed     Abstract available
    
    
    
48. LIN J, Yang W, Xin J, Cao H, et al
    Lead Optimization and Target Identification of Carboline Antifungal Agents.
    J Med Chem. 2025;68:11502-11515.
    PubMed     Abstract available
    
    
    
49. NEGI A, Perveen S, Kour H, Singh PP, et al
    Keeping Up with the Q's: Mechanistic Insights and Validation of Quinoline and Quinazoline Scaffolds as Potent Drugs against Tuberculosis.
    J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.4c02568.
    PubMed     Abstract available
    
    
    May 2025
50. SONKER H, Chaudhary K, Agrahari B, Dewan S, et al
    De Novo 3-(Phenylcarbamoyl) Benzoate Analogues: Efficacy against Multidrug-Resistant S. aureus and Elucidation of the Biodistribution Profile.
    J Med Chem. 2025;68:10329-10345.
    PubMed     Abstract available
    
    
    
51. PUJARI AK, Kirar S, Gogde K, Rawat K, et al
    Designing Lignin-Based Nanophotocomposites as Reactive Oxygen Species Generators for Inactivating Candida Strains.
    J Med Chem. 2025 May 12. doi: 10.1021/acs.jmedchem.5c00482.
    PubMed     Abstract available
    
    
    
52. ANTONINI G, Fares M, Hauck D, Mala P, et al
    Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa-Burkholderia cenocepacia Infections: A Biophysical Study.
    J Med Chem. 2025;68:9681-9693.
    PubMed     Abstract available
    
    
    
53. TIAN L, Wang T, Luan L, Meng Z, et al
    Terminally Symmetric beta-Turn Peptides for Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:9341-9356.
    PubMed     Abstract available
    
    
    
54. HEIDTMANN CV, Fisker CD, Logstrup S, Eriksen PG, et al
    Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins.
    J Med Chem. 2025;68:9479-9500.
    PubMed     Abstract available
    
    
    April 2025
55. XIE Y, Wang X, Chang T, Chen Z, et al
    Novel Aryl Sulfonium Modification on Vancomycin to Tackle MRSA and VRE In Vitro and In Vivo through Dual Enhanced Cell-Wall and Membrane Inhibition.
    J Med Chem. 2025;68:8310-8329.
    PubMed     Abstract available
    
    
    
56. LIANG T, Tu J, He Q, Zou P, et al
    Discovery of New Pyrazolone Carbothioamide Derivatives as Potent Antifungal Agents for the Treatment of Candidiasis and Cryptococcosis.
    J Med Chem. 2025;68:8439-8454.
    PubMed     Abstract available
    
    
    
57. XU T, Xue Z, Li X, Zhang M, et al
    Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties.
    J Med Chem. 2025;68:7459-7475.
    PubMed     Abstract available
    
    
    
58. LIU K, Liu Y, Wang Q, Nazare M, et al
    PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections.
    J Med Chem. 2025;68:7827-7838.
    PubMed     Abstract available
    
    
    March 2025
59. ZHANG ZM, Zhao SY, Liu WQ, Wu X, et al
    Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections.
    J Med Chem. 2025;68:6210-6232.
    PubMed     Abstract available
    
    
    
60. HE Y, Su J, Li M, Fareed MS, et al
    Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations.
    J Med Chem. 2025;68:5699-5718.
    PubMed     Abstract available
    
    
    
61. CARDOSO J, Pinto E, Sousa E, Resende DISP, et al
    Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds.
    J Med Chem. 2025;68:5006-5023.
    PubMed     Abstract available
    
    
    
62. SHARMA P, Jiang Q, Li SG, Ocke E, et al
    Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis.
    J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156.
    PubMed     Abstract available
    
    
    
63. CAZZANIGA G, Mori M, Griego A, Scarpa E, et al
    Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy.
    J Med Chem. 2025 Mar 3. doi: 10.1021/acs.jmedchem.4c02386.
    PubMed     Abstract available
    
    
    February 2025
64. ZIMMERMANN T, Feng J, Fischer S, de Campos LJ, et al
    Structural Optimization of Covalent Inhibitors for Deubiquitinase ChlaDUB1 of Chlamydia trachomatis as Antibiotic Agents.
    J Med Chem. 2025 Feb 28. doi: 10.1021/acs.jmedchem.4c02464.
    PubMed     Abstract available
    
    
    
65. XU L, Wang Y, Hu S, Pei Y, et al
    Discovery of Metabolic Reprogramming 2-Quinolones as Effective Antimicrobials for MRSA-Infected Wound Therapy.
    J Med Chem. 2025;68:3004-3019.
    PubMed     Abstract available
    
    
    January 2025
66. LI G, Chen W, Guan H, Lai Z, et al
    Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm.
    J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02598.
    PubMed     Abstract available
    
    
    
67. ZHANG M, Yang W, Liu N, Tu J, et al
    Lanosterol 14alpha-Demethylase (CYP51)/Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis.
    J Med Chem. 2025;68:1668-1681.
    PubMed     Abstract available
    
    
    
68. YAN X, Yang C, Li B, Bian Y, et al
    Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections.
    J Med Chem. 2025;68:1397-1416.
    PubMed     Abstract available
    
    
    
69. ZHANG T, Wu W, Zhao Y, Ding Z, et al
    Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
    J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02562.
    PubMed     Abstract available
    
    
    December 2024
70. LIU X, Wang D, Wei X, Yang D, et al
    Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection.
    J Med Chem. 2024;67:22145-22167.
    PubMed     Abstract available
    
    
    
71. DA SILVA FF, Paz JD, Rambo RS, Goncalves GA, et al
    Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
    J Med Chem. 2024;67:21781-21794.
    PubMed     Abstract available
    
    
    
72. RANI N, Rajmani RS, Surolia A
    Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis.
    J Med Chem. 2024 Dec 18. doi: 10.1021/acs.jmedchem.4c01844.
    PubMed     Abstract available
    
    
    
73. LIU K, Xia J, Li Y, Li BB, et al
    Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents.
    J Med Chem. 2024;67:21030-21048.
    PubMed     Abstract available
    
    
    
74. BERIDA T, Lindsley CW
    Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease.
    J Med Chem. 2024 Dec 9. doi: 10.1021/acs.jmedchem.4c02876.
    PubMed    
    
    
    November 2024
75. LIU JJ, Liu J, Huang YS, Chen WM, et al
    Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.
    J Med Chem. 2024;67:18911-18929.
    PubMed     Abstract available
    
    
    October 2024
76. YAN D, Kong H, Qu Y, Li R, et al
    Development of Phloroglucinol-Linked Tris-Quaternary Ammonium Salt Antimicrobial Peptide Mimics with Low Cytotoxicity and Broad-Spectrum Antibacterial Activity.
    J Med Chem. 2024;67:18576-18592.
    PubMed     Abstract available
    
    
    September 2024
77. MIAO ZY, Zhang XY, Long HZ, Lin J, et al
    Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.
    J Med Chem. 2024;67:16835-16857.
    PubMed     Abstract available
    
    
    
78. MAJI S, Akhtar S, Halder S, Chatterjee I, et al
    Corannulene Amino Acid-Derived Water-Soluble Amphiphilic Buckybowls as Broad-Spectrum Membrane Targeting Antibacterial Agents.
    J Med Chem. 2024;67:15041-15060.
    PubMed     Abstract available
    
    
    
79. SKUDLAREK JW, Cooke AJ, Mitchell HJ, Babaoglu K, et al
    Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
    J Med Chem. 2024;67:15620-15675.
    PubMed     Abstract available
    
    
    
80. YOUSE MS, Abutaleb NS, Nocentini A, S Abdelsattar A, et al
    Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae.
    J Med Chem. 2024;67:15537-15556.
    PubMed     Abstract available
    
    
    
81. YANG R, Cui L, Xu S, Zhong Y, et al
    Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Sep 11. doi: 10.1021/acs.jmedchem.4c01860.
    PubMed     Abstract available
    
    
    August 2024
82. LI K, Tolentino Collado J, Marden JA, Pollard AC, et al
    Biological Evaluation of d-[(18)F]Fluoroalanine and d-[(18)F]Fluoroalanine-d(3) as Positron Emission Tomography Imaging Tracers for Bacterial Infection.
    J Med Chem. 2024;67:13975-13984.
    PubMed     Abstract available
    
    
    
83. CHARRIA-GIRON E, Zeng H, Gorelik TE, Pahl A, et al
    Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis.
    J Med Chem. 2024 Aug 14. doi: 10.1021/acs.jmedchem.4c00585.
    PubMed     Abstract available
    
    
    
84. PELLICCIA S, Russomanno P, Barone S, Mateu B, et al
    A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
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