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Articles published in J Med Chem

Retrieve available abstracts of 38 articles:
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Single Articles


    April 2020
  1. MADGE HYR, Sharma H, Hussein WM, Khalil ZG, et al
    Structure-Activity Analysis of Cyclic Multicomponent Lipopeptide Self-Adjuvanting Vaccine Candidates Presenting Group A Streptococcus Antigens.
    J Med Chem. 2020 Apr 29. doi: 10.1021/acs.jmedchem.0c00203.
    PubMed     Abstract available


  2. L MOURE A, Narula G, Sorrentino F, Bojang A, et al
    A MymA bioactivated thioalkyl-benzoxazole prodrug family active against Mycobacterium tuberculosis.
    J Med Chem. 2020 Apr 10. doi: 10.1021/acs.jmedchem.0c00003.
    PubMed     Abstract available


  3. MAKAROV V, Salina E, Reynolds RC, Kyaw Zin PP, et al
    Molecule Property Analyses of Active Compounds for Mycobacterium Tuberculosis.
    J Med Chem. 2020 Apr 7. doi: 10.1021/acs.jmedchem.9b02075.
    PubMed     Abstract available


  4. SABBAH M, Mendes V, Vistal RG, Dias DM, et al
    Fragment-based design of Mycobacterium tuberculosis InhA inhibitors.
    J Med Chem. 2020 Apr 2. doi: 10.1021/acs.jmedchem.0c00007.
    PubMed     Abstract available


    January 2020
  5. BORTHWICK JA, Alemparte C, Wall I, Whitehurst BC, et al
    Mycobacterium tuberculosis Decaprenylphosphoryl-beta-D-ribose Oxidase inhibitors: expeditious reconstruction of sub-optimal hits into a series with potent in vivo activity.
    J Med Chem. 2020 Jan 10. doi: 10.1021/acs.jmedchem.9b01561.
    PubMed     Abstract available


    December 2019
  6. RYTER K, Ettenger G, Rasheed OK, Buhl C, et al
    Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis.
    J Med Chem. 2019 Dec 6. doi: 10.1021/acs.jmedchem.9b01598.
    PubMed     Abstract available


    October 2019
  7. HORSWILL AR, Gordon CP
    Structure-Activity-Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator.
    J Med Chem. 2019 Oct 28. doi: 10.1021/acs.jmedchem.9b00798.
    PubMed     Abstract available


  8. RAJPUT S, McLean KJ, Poddar H, Selvam I, et al
    Structure-activity relationships of cyclo(L-tyrosyl-L-tyrosine) derivatives binding to Mycobacterium tuberculosis CYP121: iodinated analogues promote shift to high-spin adduct.
    J Med Chem. 2019 Oct 16. doi: 10.1021/acs.jmedchem.9b01199.
    PubMed     Abstract available


    September 2019
  9. ZHAN W, Hsu HC, Morgan T, Ouellette T, et al
    Selective Phenylimidazole-based Inhibitors of the Mycobacterium tuberculosis Proteasome.
    J Med Chem. 2019 Sep 27. doi: 10.1021/acs.jmedchem.9b01187.
    PubMed     Abstract available


  10. WHITEHOUSE AJ, Libardo MDJ, Kasbekar M, Brear PD, et al
    Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode.
    J Med Chem. 2019 Sep 13. doi: 10.1021/acs.jmedchem.9b01203.
    PubMed     Abstract available


    August 2019
  11. ASHHURST A, McDonald D, Hanna C, Stanojevic V, et al
    Mucosal vaccination with a self-adjuvanted lipopeptide is immunogenic and protective against Mycobacterium tuberculosis.
    J Med Chem. 2019 Aug 2. doi: 10.1021/acs.jmedchem.9b00832.
    PubMed     Abstract available


    June 2019
  12. KULKARNI A, Soni I, Kelkar D, Dharmaraja AT, et al
    Chemoproteomics of an Indole-Based Quinone-Epoxide identifies druggable vulnerabilities in Vancomycin Resistant Staphylococcus aureus (VRSA).
    J Med Chem. 2019 Jun 26. doi: 10.1021/acs.jmedchem.9b00774.
    PubMed     Abstract available


    April 2019
  13. CRESPO RA, Dang Q, Zhou NE, Guthrie LM, et al
    Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
    J Med Chem. 2019 Apr 19. doi: 10.1021/acs.jmedchem.9b00020.
    PubMed     Abstract available


    March 2019
  14. ZHANG W, Lun S, Liu LL, Xiao S, et al
    Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
    J Med Chem. 2019 Mar 15. doi: 10.1021/acs.jmedchem.9b00010.
    PubMed     Abstract available


    February 2019
  15. WANG X, Zeng Y, Sheng L, Larson P, et al
    A Cinchona Alkaloid Antibiotic that Appears to Target ATP Synthase in Streptococcus pneumoniae.
    J Med Chem. 2019 Feb 19. doi: 10.1021/acs.jmedchem.8b01353.
    PubMed     Abstract available


  16. TU J, Li Z, Jiang Y, Ji C, et al
    Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis.
    J Med Chem. 2019 Feb 12. doi: 10.1021/acs.jmedchem.8b01598.
    PubMed     Abstract available


    November 2018
  17. GUARDIA A, Baiget J, Cacho M, Perez A, et al
    Easy-to-Synthesize Spirocyclic Compounds Possess Remarkable In Vivo Activity Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Nov 20. doi: 10.1021/acs.jmedchem.8b01533.
    PubMed     Abstract available


  18. KUNKLE T, Abdeen S, Salim N, Ray AM, et al
    Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus.
    J Med Chem. 2018 Nov 4. doi: 10.1021/acs.jmedchem.8b01293.
    PubMed     Abstract available


  19. MIZAR P, Arya R, Kim T, Cha S, et al
    Total synthesis of Xanthoangelol B and its various fragments: towards inhibition of virulence factor production of Staphylococcus aureus.
    J Med Chem. 2018 Nov 2. doi: 10.1021/acs.jmedchem.8b01012.
    PubMed     Abstract available


    August 2018
  20. VICKERS C, Silva A, Chakraborty A, Fernandez P, et al
    Structure-based design of MptpB inhibitors that reduce multi-drug-resistant Mycobacterium tuberculosis survival and infection burden in vivo.
    J Med Chem. 2018 Aug 28. doi: 10.1021/acs.jmedchem.8b00832.
    PubMed     Abstract available


    July 2018
  21. ABDEEN S, Kunkle T, Salim N, Ray AM, et al
    Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2018 Jul 30. doi: 10.1021/acs.jmedchem.8b00989.
    PubMed     Abstract available


    June 2018
  22. CLEGHORN LAT, Ray P, Odingo J, Kumar A, et al
    Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
    J Med Chem. 2018 Jun 26. doi: 10.1021/acs.jmedchem.8b00172.
    PubMed     Abstract available


    May 2018
  23. CHIKHALE RV, Barmade MA, Murumkar PR, Yadav MR, et al
    An Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis.
    J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.8b00281.
    PubMed     Abstract available


  24. CHACKO S, Boshoff HIM, Singh V, Ferraris DM, et al
    Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.
    J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.7b01839.
    PubMed     Abstract available


    March 2018
  25. TRAPERO A, Pacitto A, Singh V, Sabbah M, et al
    Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
    J Med Chem. 2018 Mar 23. doi: 10.1021/acs.jmedchem.7b01622.
    PubMed     Abstract available


  26. SONG L, Merceron R, Gracia B, Quintana AL, et al
    Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors.
    J Med Chem. 2018 Mar 6. doi: 10.1021/acs.jmedchem.7b01570.
    PubMed     Abstract available


    February 2018
  27. CAI S, Qiao X, Feng L, Shi N, et al
    Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality.
    J Med Chem. 2018 Feb 21. doi: 10.1021/acs.jmedchem.8b00036.
    PubMed     Abstract available


    January 2018
  28. PARMAR A, Lakshminarayanan R, Iyer A, Mayandi V, et al
    Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE) in vitro and in vivo.
    J Med Chem. 2018 Jan 24. doi: 10.1021/acs.jmedchem.7b01634.
    PubMed     Abstract available


  29. ZHANG W, Lun S, Wang SH, Jiang X, et al
    Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Jan 12. doi: 10.1021/acs.jmedchem.7b01319.
    PubMed     Abstract available


    December 2017
  30. GUAN D, Chen F, Xiong L, Tang F, et al
    Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
    J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01345.
    PubMed     Abstract available


  31. CAMERON AJ, Edwards PJB, Harjes E, Sarojini V, et al
    Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
    J Med Chem. 2017;60:9565-9574.
    PubMed     Abstract available


  32. MOON SH, Zhang X, Zheng G, Meeker DG, et al
    Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin.
    J Med Chem. 2017;60:9630-9640.
    PubMed     Abstract available


  33. CHOI H, Ham SY, Cha E, Shin Y, et al
    Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents.
    J Med Chem. 2017;60:9821-9837.
    PubMed     Abstract available


    October 2017
  34. GOOD JAD, Kulen M, Silver J, Krishnan KS, et al
    Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity.
    J Med Chem. 2017 Oct 20. doi: 10.1021/acs.jmedchem.7b00716.
    PubMed     Abstract available


    September 2017
  35. LI X, Hernandez V, Rock FL, Choi W, et al
    Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
    J Med Chem. 2017 Sep 27. doi: 10.1021/acs.jmedchem.7b00631.
    PubMed     Abstract available


  36. BUCHIERI MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, et al
    Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.
    J Med Chem. 2017;60:7425-7433.
    PubMed     Abstract available


  37. CHEN AY, Thomas PW, Stewart AC, Bergstrom A, et al
    Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-beta-lactamase-1.
    J Med Chem. 2017;60:7267-7283.
    PubMed     Abstract available


  38. ABDEL MONAIM SAH, Ramchuran EJ, El-Faham A, Albericio F, et al
    Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
    J Med Chem. 2017;60:7476-7482.
    PubMed     Abstract available


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