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  Bacterial Infections and Mycoses

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Articles published in J Med Chem

Retrieve available abstracts of 39 articles:
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Single Articles


    October 2021
  1. FRIDIANTO KT, Li M, Hards K, Negatu DA, et al
    Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis.
    J Med Chem. 2021 Oct 27. doi: 10.1021/acs.jmedchem.1c01383.
    PubMed     Abstract available


  2. CHEN Z, Song K, Shang Y, Xiong Y, et al
    Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis.
    J Med Chem. 2021 Oct 16. doi: 10.1021/acs.jmedchem.1c00939.
    PubMed     Abstract available


    August 2021
  3. PEUKERT C, Langer LNB, Wegener SM, Tutov A, et al
    Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections.
    J Med Chem. 2021;64:12359-12378.
    PubMed     Abstract available


  4. GUO Y, Hou E, Wen T, Yan X, et al
    Development of Membrane-Active Honokiol/Magnolol Amphiphiles as Potent Antibacterial Agents against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2021 Aug 25. doi: 10.1021/acs.jmedchem.1c01073.
    PubMed     Abstract available


  5. KHONDE LP, Muller R, Boyle GA, Reddy V, et al
    1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2021 Aug 20. doi: 10.1021/acs.jmedchem.1c00837.
    PubMed     Abstract available


    July 2021
  6. KATO I, Ukai Y, Kondo N, Nozu K, et al
    Identification of Thiazoyl Guanidine Derivatives as Novel Antifungal Agents Inhibiting Ergosterol Biosynthesis for Treatment of Invasive Fungal Infections.
    J Med Chem. 2021;64:10482-10496.
    PubMed     Abstract available


    June 2021
  7. KONG Q, Pan W, Xu H, Xue Y, et al
    Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
    J Med Chem. 2021;64:8644-8665.
    PubMed     Abstract available


  8. VAN DER WESTHUYZEN R, Mabhula A, Njaria PM, Muller R, et al
    Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
    J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00707.
    PubMed     Abstract available


  9. WANG Z, Li J, Benin BM, Yu B, et al
    Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus.
    J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00656.
    PubMed     Abstract available


  10. NACLERIO GA, Sintim HO
    Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.
    J Med Chem. 2021;64:7272-7274.
    PubMed     Abstract available


  11. YANG H, Kundra S, Chojnacki M, Liu K, et al
    A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.
    J Med Chem. 2021;64:7275-7295.
    PubMed     Abstract available


    May 2021
  12. SUN W, Jian Y, Zhou M, Yao Y, et al
    Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile Ligands.
    J Med Chem. 2021 May 25. doi: 10.1021/acs.jmedchem.0c02257.
    PubMed     Abstract available


  13. KEOUGH DT, Wun SJ, Baszczynski O, Eng WS, et al
    Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
    J Med Chem. 2021;64:5710-5729.
    PubMed     Abstract available


  14. ZHANG H, Hsu HC, Kahne SC, Hara R, et al
    Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
    J Med Chem. 2021 May 5. doi: 10.1021/acs.jmedchem.1c00296.
    PubMed     Abstract available


    April 2021
  15. SHARMA A, De Rosa M, Singla N, Singh G, et al
    Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains.
    J Med Chem. 2021 Apr 7. doi: 10.1021/acs.jmedchem.0c01833.
    PubMed     Abstract available


    March 2021
  16. WU Y, Wang B, Lu H, Zhao H, et al
    Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens.
    J Med Chem. 2021;64:3234-3248.
    PubMed     Abstract available


    February 2021
  17. AZUAR A, Li Z, Shibu MA, Zhao L, et al
    Poly(hydrophobic amino acid)-Based Self-Adjuvanting Nanoparticles for Group A Streptococcus Vaccine Delivery.
    J Med Chem. 2021 Feb 2. doi: 10.1021/acs.jmedchem.0c01660.
    PubMed     Abstract available


    January 2021
  18. KANDALE A, Patel K, Hussein WM, Wun SJ, et al
    Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads.
    J Med Chem. 2021 Jan 29. doi: 10.1021/acs.jmedchem.0c01919.
    PubMed     Abstract available


  19. LI Z, Tu J, Han G, Liu N, et al
    Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2021;64:1116-1126.
    PubMed     Abstract available


    December 2020
  20. SHYAM M, Shilkar D, Verma H, Dev A, et al
    The Mycobactin Biosynthesis Pathway: A Prospective Therapeutic Target in the Battle against Tuberculosis.
    J Med Chem. 2020 Dec 29. doi: 10.1021/acs.jmedchem.0c01176.
    PubMed     Abstract available


  21. KUMAR G, Narayan R, Kapoor S
    Chemical Tools for Illumination of Tuberculosis Biology, Virulence Mechanisms, and Diagnosis.
    J Med Chem. 2020 Dec 13. doi: 10.1021/acs.jmedchem.0c01337.
    PubMed     Abstract available


    November 2020
  22. SCHEUPLEIN NJ, Bzdyl NM, Kibble EA, Lohr T, et al
    Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.
    J Med Chem. 2020;63:13355-13388.
    PubMed     Abstract available


  23. KARAS JA, Carter GP, Howden BP, Turner AM, et al
    Structure-Activity Relationships of Daptomycin Lipopeptides.
    J Med Chem. 2020;63:13266-13290.
    PubMed     Abstract available


  24. LIU W, Yuan L, Wang S
    Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall.
    J Med Chem. 2020;63:12429-12459.
    PubMed     Abstract available


    October 2020
  25. REHBERG N, Sommer GA, Driessen D, Kruppa M, et al
    Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2020 Oct 25. doi: 10.1021/acs.jmedchem.0c00826.
    PubMed     Abstract available


  26. BASARAB GS, Doig P, Eyermann CJ, Galullo V, et al
    Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
    J Med Chem. 2020;63:11882-11901.
    PubMed     Abstract available


    September 2020
  27. LIEUTAUD A, Pieri C, Bolla JM, Brunel JM, et al
    New Polyaminoisoprenyl Antibiotics Enhancers against Two Multidrug-Resistant Gram-Negative Bacteria from Enterobacter and Salmonella Species.
    J Med Chem. 2020;63:10496-10508.
    PubMed     Abstract available


  28. FEI Y, Wu J, An HW, Zhu K, et al
    Identification of New Nitric Oxide-Donating Peptides with Dual Biofilm Eradication and Antibacterial Activities for Intervention of Device-Related Infections.
    J Med Chem. 2020;63:9127-9135.
    PubMed     Abstract available


  29. ETAYASH H, Pletzer D, Kumar P, Straus SK, et al
    Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
    J Med Chem. 2020;63:9228-9236.
    PubMed     Abstract available


    August 2020
  30. NAM S, Ham SY, Kwon H, Kim HS, et al
    Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections.
    J Med Chem. 2020;63:8388-8407.
    PubMed     Abstract available


  31. KONSTANTINOVIC J, Yahiaoui S, Alhayek A, Haupenthal J, et al
    N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
    J Med Chem. 2020;63:8359-8368.
    PubMed     Abstract available


    July 2020
  32. HECKER SJ, Reddy KR, Lomovskaya O, Griffith DC, et al
    Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases.
    J Med Chem. 2020;63:7491-7507.
    PubMed     Abstract available


  33. BLAKE S, Thanissery R, Rivera AJ, Hixon MS, et al
    Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice.
    J Med Chem. 2020;63:6898-6908.
    PubMed     Abstract available


    June 2020
  34. FERNANDES P, Pereira D, Watkins PB, Bertrand D, et al
    Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics.
    J Med Chem. 2020;63:6462-6473.
    PubMed     Abstract available


  35. LIN S, Li H, Tao Y, Liu J, et al
    In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria.
    J Med Chem. 2020;63:5797-5815.
    PubMed     Abstract available


    May 2020
  36. HAN G, Liu N, Li C, Tu J, et al
    Discovery of Novel Fungal Lanosterol 14alpha-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
    J Med Chem. 2020;63:5341-5359.
    PubMed     Abstract available


  37. BALABON O, Pitta E, Rogacki MK, Meiler E, et al
    Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-beta-d-Ribose Oxidase (DprE1) Inhibitors.
    J Med Chem. 2020;63:5367-5386.
    PubMed     Abstract available


    April 2020
  38. MAYANDI V, Xi Q, Leng Goh ET, Koh SK, et al
    Rational Substitution of epsilon-Lysine for alpha-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin.
    J Med Chem. 2020;63:3522-3537.
    PubMed     Abstract available


  39. MAVRIDIS IM, Yannakopoulou K
    Porphyrinoid-Cyclodextrin Assemblies in Biomedical Research: An Update.
    J Med Chem. 2020;63:3391-3424.
    PubMed     Abstract available


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