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Articles published in J Med Chem

Retrieve available abstracts of 61 articles:
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Single Articles


    June 2022
  1. BURASTERO O, Defelipe LA, Gola G, Tateosian NL, et al
    Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
    J Med Chem. 2022 Jun 23. doi: 10.1021/acs.jmedchem.1c02012.
    PubMed     Abstract available


  2. ZHANG X, Wang M, Zhu X, Peng Y, et al
    Development of Lipo-gamma-AA Peptides as Potent Antifungal Agents.
    J Med Chem. 2022;65:8029-8039.
    PubMed     Abstract available


    May 2022
  3. WU Y, Jiang W, Cong Z, Chen K, et al
    An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections.
    J Med Chem. 2022;65:7296-7311.
    PubMed     Abstract available


  4. FERNANDES GFS, Thompson AM, Castagnolo D, Denny WA, et al
    Tuberculosis Drug Discovery: Challenges and New Horizons.
    J Med Chem. 2022 May 25. doi: 10.1021/acs.jmedchem.2c00227.
    PubMed     Abstract available


  5. KOKOT M, Anderluh M, Hrast M, Minovski N, et al
    The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.
    J Med Chem. 2022;65:6431-6440.
    PubMed     Abstract available


  6. NACLERIO GA, Abutaleb NS, Onyedibe KI, Karanja C, et al
    Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.
    J Med Chem. 2022;65:6612-6630.
    PubMed     Abstract available


  7. LI W, Yun Z, Ji C, Tu J, et al
    Discovery of Novel Sertraline Derivatives as Potent Anti-Cryptococcus Agents.
    J Med Chem. 2022;65:6541-6554.
    PubMed     Abstract available


    April 2022
  8. GURVIC D, Leach AG, Zachariae U
    Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria.
    J Med Chem. 2022;65:6088-6099.
    PubMed     Abstract available


  9. LELLA M, Oh MW, Kuo SH, Lau GW, et al
    Attenuating the Streptococcus pneumoniae Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs.
    J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.2c00148.
    PubMed     Abstract available


  10. YIN W, Wu T, Liu L, Jiang H, et al
    Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2022;65:5539-5564.
    PubMed     Abstract available


    March 2022
  11. MA Z, He S, Yuan Y, Zhuang Z, et al
    Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
    J Med Chem. 2022;65:4481-4495.
    PubMed     Abstract available


  12. KOBAURI P, Galenkamp NS, Schulte AM, de Vries J, et al
    Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors.
    J Med Chem. 2022;65:4798-4817.
    PubMed     Abstract available


    February 2022
  13. ACEBRON-GARCIA-DE-EULATE M, Mayol-Llinas J, Holland MTO, Kim SY, et al
    Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
    J Med Chem. 2022;65:2149-2173.
    PubMed     Abstract available


  14. MODAK B, Girkar S, Narayan R, Kapoor S, et al
    Mycobacterial Membranes as Actionable Targets for Lipid-Centric Therapy in Tuberculosis.
    J Med Chem. 2022 Feb 8. doi: 10.1021/acs.jmedchem.1c01870.
    PubMed     Abstract available


    January 2022
  15. OTTAVI S, Scarry SM, Mosior J, Ling Y, et al
    In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
    J Med Chem. 2022 Jan 19. doi: 10.1021/acs.jmedchem.1c01565.
    PubMed     Abstract available


  16. SHYAM M, Verma H, Bhattacharje G, Mukherjee P, et al
    Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
    J Med Chem. 2022;65:234-256.
    PubMed     Abstract available


  17. HU Y, Li H, Qu R, He T, et al
    Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo.
    J Med Chem. 2022;65:579-591.
    PubMed     Abstract available


  18. LIU J, Hou JS, Chang YQ, Peng LJ, et al
    New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergist against Multidrug-Resistant Pseudomonas aeruginosa.
    J Med Chem. 2022;65:688-709.
    PubMed     Abstract available


  19. LEE D, Lee E, Jang S, Kim K, et al
    Discovery of Mycobacterium tuberculosis Rv3364c-Derived Small Molecules as Potential Therapeutic Agents to Target SNX9 for Sepsis.
    J Med Chem. 2022 Jan 4. doi: 10.1021/acs.jmedchem.1c01551.
    PubMed     Abstract available


    November 2021
  20. TRAN W, Kusay AS, Hawkins PME, Cheung CY, et al
    Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.
    J Med Chem. 2021 Nov 30. doi: 10.1021/acs.jmedchem.1c01407.
    PubMed     Abstract available


  21. CHOI JW, Lee KT, Kim S, Lee YR, et al
    Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection.
    J Med Chem. 2021;64:15912-15935.
    PubMed     Abstract available


    October 2021
  22. PRATAP VERMA D, Ansari MM, Verma NK, Saroj J, et al
    Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
    J Med Chem. 2021;64:15349-15366.
    PubMed     Abstract available


  23. FRIDIANTO KT, Li M, Hards K, Negatu DA, et al
    Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis.
    J Med Chem. 2021 Oct 27. doi: 10.1021/acs.jmedchem.1c01383.
    PubMed     Abstract available


  24. CHEN Z, Song K, Shang Y, Xiong Y, et al
    Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis.
    J Med Chem. 2021 Oct 16. doi: 10.1021/acs.jmedchem.1c00939.
    PubMed     Abstract available


    August 2021
  25. PEUKERT C, Langer LNB, Wegener SM, Tutov A, et al
    Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections.
    J Med Chem. 2021;64:12359-12378.
    PubMed     Abstract available


  26. GUO Y, Hou E, Wen T, Yan X, et al
    Development of Membrane-Active Honokiol/Magnolol Amphiphiles as Potent Antibacterial Agents against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2021 Aug 25. doi: 10.1021/acs.jmedchem.1c01073.
    PubMed     Abstract available


  27. KHONDE LP, Muller R, Boyle GA, Reddy V, et al
    1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2021 Aug 20. doi: 10.1021/acs.jmedchem.1c00837.
    PubMed     Abstract available


    July 2021
  28. KATO I, Ukai Y, Kondo N, Nozu K, et al
    Identification of Thiazoyl Guanidine Derivatives as Novel Antifungal Agents Inhibiting Ergosterol Biosynthesis for Treatment of Invasive Fungal Infections.
    J Med Chem. 2021;64:10482-10496.
    PubMed     Abstract available


    June 2021
  29. KONG Q, Pan W, Xu H, Xue Y, et al
    Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
    J Med Chem. 2021;64:8644-8665.
    PubMed     Abstract available


  30. VAN DER WESTHUYZEN R, Mabhula A, Njaria PM, Muller R, et al
    Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
    J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00707.
    PubMed     Abstract available


  31. WANG Z, Li J, Benin BM, Yu B, et al
    Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus.
    J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00656.
    PubMed     Abstract available


  32. NACLERIO GA, Sintim HO
    Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.
    J Med Chem. 2021;64:7272-7274.
    PubMed     Abstract available


  33. YANG H, Kundra S, Chojnacki M, Liu K, et al
    A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.
    J Med Chem. 2021;64:7275-7295.
    PubMed     Abstract available


    May 2021
  34. SUN W, Jian Y, Zhou M, Yao Y, et al
    Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile Ligands.
    J Med Chem. 2021 May 25. doi: 10.1021/acs.jmedchem.0c02257.
    PubMed     Abstract available


  35. KEOUGH DT, Wun SJ, Baszczynski O, Eng WS, et al
    Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
    J Med Chem. 2021;64:5710-5729.
    PubMed     Abstract available


  36. ZHANG H, Hsu HC, Kahne SC, Hara R, et al
    Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
    J Med Chem. 2021 May 5. doi: 10.1021/acs.jmedchem.1c00296.
    PubMed     Abstract available


    April 2021
  37. SHARMA A, De Rosa M, Singla N, Singh G, et al
    Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains.
    J Med Chem. 2021 Apr 7. doi: 10.1021/acs.jmedchem.0c01833.
    PubMed     Abstract available


    March 2021
  38. WU Y, Wang B, Lu H, Zhao H, et al
    Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens.
    J Med Chem. 2021;64:3234-3248.
    PubMed     Abstract available


    February 2021
  39. AZUAR A, Li Z, Shibu MA, Zhao L, et al
    Poly(hydrophobic amino acid)-Based Self-Adjuvanting Nanoparticles for Group A Streptococcus Vaccine Delivery.
    J Med Chem. 2021 Feb 2. doi: 10.1021/acs.jmedchem.0c01660.
    PubMed     Abstract available


    January 2021
  40. KANDALE A, Patel K, Hussein WM, Wun SJ, et al
    Analogues of the Herbicide, N-Hydroxy-N-isopropyloxamate, Inhibit Mycobacterium tuberculosis Ketol-Acid Reductoisomerase and Their Prodrugs Are Promising Anti-TB Drug Leads.
    J Med Chem. 2021 Jan 29. doi: 10.1021/acs.jmedchem.0c01919.
    PubMed     Abstract available


  41. LI Z, Tu J, Han G, Liu N, et al
    Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2021;64:1116-1126.
    PubMed     Abstract available


    December 2020
  42. SHYAM M, Shilkar D, Verma H, Dev A, et al
    The Mycobactin Biosynthesis Pathway: A Prospective Therapeutic Target in the Battle against Tuberculosis.
    J Med Chem. 2020 Dec 29. doi: 10.1021/acs.jmedchem.0c01176.
    PubMed     Abstract available


  43. KUMAR G, Narayan R, Kapoor S
    Chemical Tools for Illumination of Tuberculosis Biology, Virulence Mechanisms, and Diagnosis.
    J Med Chem. 2020 Dec 13. doi: 10.1021/acs.jmedchem.0c01337.
    PubMed     Abstract available


    November 2020
  44. SCHEUPLEIN NJ, Bzdyl NM, Kibble EA, Lohr T, et al
    Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.
    J Med Chem. 2020;63:13355-13388.
    PubMed     Abstract available


  45. KARAS JA, Carter GP, Howden BP, Turner AM, et al
    Structure-Activity Relationships of Daptomycin Lipopeptides.
    J Med Chem. 2020;63:13266-13290.
    PubMed     Abstract available


  46. LIU W, Yuan L, Wang S
    Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall.
    J Med Chem. 2020;63:12429-12459.
    PubMed     Abstract available


    October 2020
  47. REHBERG N, Sommer GA, Driessen D, Kruppa M, et al
    Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2020 Oct 25. doi: 10.1021/acs.jmedchem.0c00826.
    PubMed     Abstract available


  48. BASARAB GS, Doig P, Eyermann CJ, Galullo V, et al
    Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
    J Med Chem. 2020;63:11882-11901.
    PubMed     Abstract available


    September 2020
  49. LIEUTAUD A, Pieri C, Bolla JM, Brunel JM, et al
    New Polyaminoisoprenyl Antibiotics Enhancers against Two Multidrug-Resistant Gram-Negative Bacteria from Enterobacter and Salmonella Species.
    J Med Chem. 2020;63:10496-10508.
    PubMed     Abstract available


  50. FEI Y, Wu J, An HW, Zhu K, et al
    Identification of New Nitric Oxide-Donating Peptides with Dual Biofilm Eradication and Antibacterial Activities for Intervention of Device-Related Infections.
    J Med Chem. 2020;63:9127-9135.
    PubMed     Abstract available


  51. ETAYASH H, Pletzer D, Kumar P, Straus SK, et al
    Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity.
    J Med Chem. 2020;63:9228-9236.
    PubMed     Abstract available


    August 2020
  52. NAM S, Ham SY, Kwon H, Kim HS, et al
    Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections.
    J Med Chem. 2020;63:8388-8407.
    PubMed     Abstract available


  53. KONSTANTINOVIC J, Yahiaoui S, Alhayek A, Haupenthal J, et al
    N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
    J Med Chem. 2020;63:8359-8368.
    PubMed     Abstract available


    July 2020
  54. HECKER SJ, Reddy KR, Lomovskaya O, Griffith DC, et al
    Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-beta-lactamases.
    J Med Chem. 2020;63:7491-7507.
    PubMed     Abstract available


  55. BLAKE S, Thanissery R, Rivera AJ, Hixon MS, et al
    Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice.
    J Med Chem. 2020;63:6898-6908.
    PubMed     Abstract available


    June 2020
  56. FERNANDES P, Pereira D, Watkins PB, Bertrand D, et al
    Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics.
    J Med Chem. 2020;63:6462-6473.
    PubMed     Abstract available


  57. LIN S, Li H, Tao Y, Liu J, et al
    In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria.
    J Med Chem. 2020;63:5797-5815.
    PubMed     Abstract available


    May 2020
  58. HAN G, Liu N, Li C, Tu J, et al
    Discovery of Novel Fungal Lanosterol 14alpha-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
    J Med Chem. 2020;63:5341-5359.
    PubMed     Abstract available


  59. BALABON O, Pitta E, Rogacki MK, Meiler E, et al
    Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-beta-d-Ribose Oxidase (DprE1) Inhibitors.
    J Med Chem. 2020;63:5367-5386.
    PubMed     Abstract available


    April 2020
  60. MAYANDI V, Xi Q, Leng Goh ET, Koh SK, et al
    Rational Substitution of epsilon-Lysine for alpha-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin.
    J Med Chem. 2020;63:3522-3537.
    PubMed     Abstract available


  61. MAVRIDIS IM, Yannakopoulou K
    Porphyrinoid-Cyclodextrin Assemblies in Biomedical Research: An Update.
    J Med Chem. 2020;63:3391-3424.
    PubMed     Abstract available


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