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Articles published in J Med Chem

Retrieve available abstracts of 22 articles:
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Single Articles


    November 2018
  1. GUARDIA A, Baiget J, Cacho M, Perez A, et al
    Easy-to-Synthesize Spirocyclic Compounds Possess Remarkable In Vivo Activity Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Nov 20. doi: 10.1021/acs.jmedchem.8b01533.
    PubMed     Text format     Abstract available


  2. KUNKLE T, Abdeen S, Salim N, Ray AM, et al
    Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus.
    J Med Chem. 2018 Nov 4. doi: 10.1021/acs.jmedchem.8b01293.
    PubMed     Text format     Abstract available


  3. MIZAR P, Arya R, Kim T, Cha S, et al
    Total synthesis of Xanthoangelol B and its various fragments: towards inhibition of virulence factor production of Staphylococcus aureus.
    J Med Chem. 2018 Nov 2. doi: 10.1021/acs.jmedchem.8b01012.
    PubMed     Text format     Abstract available


    August 2018
  4. VICKERS C, Silva A, Chakraborty A, Fernandez P, et al
    Structure-based design of MptpB inhibitors that reduce multi-drug-resistant Mycobacterium tuberculosis survival and infection burden in vivo.
    J Med Chem. 2018 Aug 28. doi: 10.1021/acs.jmedchem.8b00832.
    PubMed     Text format     Abstract available


    July 2018
  5. ABDEEN S, Kunkle T, Salim N, Ray AM, et al
    Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2018 Jul 30. doi: 10.1021/acs.jmedchem.8b00989.
    PubMed     Text format     Abstract available


    June 2018
  6. CLEGHORN LAT, Ray P, Odingo J, Kumar A, et al
    Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
    J Med Chem. 2018 Jun 26. doi: 10.1021/acs.jmedchem.8b00172.
    PubMed     Text format     Abstract available


    May 2018
  7. CHIKHALE RV, Barmade MA, Murumkar PR, Yadav MR, et al
    An Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis.
    J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.8b00281.
    PubMed     Text format     Abstract available


  8. CHACKO S, Boshoff HIM, Singh V, Ferraris DM, et al
    Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.
    J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.7b01839.
    PubMed     Text format     Abstract available


    March 2018
  9. TRAPERO A, Pacitto A, Singh V, Sabbah M, et al
    Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.
    J Med Chem. 2018 Mar 23. doi: 10.1021/acs.jmedchem.7b01622.
    PubMed     Text format     Abstract available


  10. SONG L, Merceron R, Gracia B, Quintana AL, et al
    Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors.
    J Med Chem. 2018 Mar 6. doi: 10.1021/acs.jmedchem.7b01570.
    PubMed     Text format     Abstract available


    February 2018
  11. CAI S, Qiao X, Feng L, Shi N, et al
    Python Cathelicidin CATHPb1 Protects against Multidrug-Resistant Staphylococcal Infections by Antimicrobial-Immunomodulatory Duality.
    J Med Chem. 2018 Feb 21. doi: 10.1021/acs.jmedchem.8b00036.
    PubMed     Text format     Abstract available


    January 2018
  12. PARMAR A, Lakshminarayanan R, Iyer A, Mayandi V, et al
    Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE) in vitro and in vivo.
    J Med Chem. 2018 Jan 24. doi: 10.1021/acs.jmedchem.7b01634.
    PubMed     Text format     Abstract available


  13. ZHANG W, Lun S, Wang SH, Jiang X, et al
    Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors Against Mycobacterium Tuberculosis.
    J Med Chem. 2018 Jan 12. doi: 10.1021/acs.jmedchem.7b01319.
    PubMed     Text format     Abstract available


    December 2017
  14. GUAN D, Chen F, Xiong L, Tang F, et al
    Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
    J Med Chem. 2017 Dec 15. doi: 10.1021/acs.jmedchem.7b01345.
    PubMed     Text format     Abstract available


  15. CAMERON AJ, Edwards PJB, Harjes E, Sarojini V, et al
    Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
    J Med Chem. 2017;60:9565-9574.
    PubMed     Text format     Abstract available


  16. MOON SH, Zhang X, Zheng G, Meeker DG, et al
    Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin.
    J Med Chem. 2017;60:9630-9640.
    PubMed     Text format     Abstract available


  17. CHOI H, Ham SY, Cha E, Shin Y, et al
    Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents.
    J Med Chem. 2017;60:9821-9837.
    PubMed     Text format     Abstract available


    October 2017
  18. GOOD JAD, Kulen M, Silver J, Krishnan KS, et al
    Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity.
    J Med Chem. 2017 Oct 20. doi: 10.1021/acs.jmedchem.7b00716.
    PubMed     Text format     Abstract available


    September 2017
  19. LI X, Hernandez V, Rock FL, Choi W, et al
    Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
    J Med Chem. 2017 Sep 27. doi: 10.1021/acs.jmedchem.7b00631.
    PubMed     Text format     Abstract available


  20. BUCHIERI MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, et al
    Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.
    J Med Chem. 2017;60:7425-7433.
    PubMed     Text format     Abstract available


  21. CHEN AY, Thomas PW, Stewart AC, Bergstrom A, et al
    Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-beta-lactamase-1.
    J Med Chem. 2017;60:7267-7283.
    PubMed     Text format     Abstract available


  22. ABDEL MONAIM SAH, Ramchuran EJ, El-Faham A, Albericio F, et al
    Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
    J Med Chem. 2017;60:7476-7482.
    PubMed     Text format     Abstract available


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