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Leukemia

Free Subscription 15.12.2025 2 Am J Clin Pathol 2 Am J Hematol 1 Biochem Biophys Res Commun 1 Biochem Pharmacol 2 Blood 3 BMC Cancer 2 Bone Marrow Transplant 3 Cancer 1 Eur J Haematol 1 Genomics 2 Int J Hematol 4 J Clin Oncol 2 J Pediatr Hematol Oncol 1 Leuk Lymphoma 1 Leuk Res 6 Leukemia 2 N Engl J Med

Retrieve available abstracts of this week’s articles: HTML format

Single Articles

Am J Clin Pathol

1. SATAPATHY P, Mehta R, Sah R
   Comment on "Methylation-based droplet digital polymerase chain reaction shows high concordance with chronic lymphocytic leukemia IGHV somatic mutation status".
   Am J Clin Pathol. 2025 Dec 5:aqaf118. doi: 10.1093.
   PubMed        
   
   
2. SABATINI P, Zhang T, Boruvka N, Kim HS, et al
   Reply to "Methylation-based droplet digital polymerase chain reaction shows high concordance with chronic lymphocytic leukemia IGHV somatic mutation status".
   Am J Clin Pathol. 2025 Dec 4:aqaf120. doi: 10.1093.
   PubMed        
   
   

   
   Am J Hematol

3. BYSTROM R, Fernandes LL, Wynne J, Pulte D, et al
   Real-World Outcomes and Treatment Patterns in Patients With Acute Myeloid Leukemia and TP53 Gene Mutation or 17p Deletion.
   Am J Hematol. 2025 Dec 13. doi: 10.1002/ajh.70165.
   PubMed         Abstract available
   
   
4. TONG X, Xu B, Zhang S, Li M, et al
   DIA Regimen Versus IA Regimen for Induction Therapy in Younger Adults With Acute Myeloid Leukemia: A Multicenter Open-Label Randomized Controlled Trial.
   Am J Hematol. 2025 Dec 6. doi: 10.1002/ajh.70157.
   PubMed        
   
   

   
   Biochem Biophys Res Commun

5. TANG BJ, Chen L, Huang ST, Zhong AN, et al
   Exosomal circ_0058493 promotes imatinib resistance via miR-548b-3p/U2SURP axis in CML cells.
   Biochem Biophys Res Commun. 2025;793:153012.
   PubMed         Abstract available
   
   

   
   Biochem Pharmacol

6. YANG Q, Liu JY, Liu SM, Song WJ, et al
   Deubiquitinase USP5 promotes acute myeloid leukemia through C2CD5 stabilization and PI3K/AKT/mTOR/HIF-1alpha-driven glycolysis.
   Biochem Pharmacol. 2025;244:117591.
   PubMed         Abstract available
   
   

   
   Blood

7. MARTINEZ TC, Jotte MRM, Khan S, Stoddart A, et al
   CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell-intrinsic inflammatory pathways.
   Blood. 2025 Sep 8:blood.2024026815. doi: 10.1182/blood.2024026815.
   PubMed         Abstract available
   
   
8. SOUTO FILHO JTD, Paulo AB
   Promyelocyte maturation arrest after rituximab-induced late-onset neutropenia mimicking acute promyelocytic leukemia.
   Blood. 2025;146:3003.
   PubMed        
   
   

   
   BMC Cancer

9. ARIF K, Yousaf M, Khan D
   Targeting Musashi-2 to counteract senescence and resistance in chronic myeloid leukemia: enhancing the efficacy of imatinib therapy.
   BMC Cancer. 2025 Dec 7. doi: 10.1186/s12885-025-15214.
   PubMed         Abstract available
   
   
10. BUSHAWAY S, Naumann K, Singh B, Maher C, et al
    Preparing for allogeneic hematopoietic stem cell transplant: a multidisciplinary prehabilitation intervention is safe, feasible and demonstrates preliminary efficacy in acute myeloid leukemia and myelodysplastic syndromes.
    BMC Cancer. 2025 Dec 9. doi: 10.1186/s12885-025-15417.
    PubMed        
    
    
11. HONG Y, Wang X, Dong J, Liu Q, et al
    New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein.
    BMC Cancer. 2025 Dec 10. doi: 10.1186/s12885-025-15438.
    PubMed        
    
    

    
    Bone Marrow Transplant

12. WETHMAR K, Edinger M, Schafer-Eckart K, Stelljes M, et al
    Reduced intensity conditioning with 8 Gy total body irradiation in adult patients with acute lymphoblastic leukemia.
    Bone Marrow Transplant. 2025 Dec 6. doi: 10.1038/s41409-025-02762.
    PubMed         Abstract available
    
    
13. BAZARBACHI A, Galimard JE, Abou Dalle I, Labopin M, et al
    Frequency and impact of somatic co-occurring mutations on post-transplant outcomes in acute myeloid leukemia: a multicenter registry analysis on behalf of the EBMT ALWP.
    Bone Marrow Transplant. 2025 Dec 5. doi: 10.1038/s41409-025-02770.
    PubMed         Abstract available
    
    

    
    Cancer

14. ARGUELLO-TOMAS M, Lynton-Pons E, Albiol N, Lopez-Ferrer A, et al
    Clinical and immunologic characteristics of nonhematologic autoimmune disorders in chronic lymphocytic leukemia.
    Cancer. 2025;131:e70216.
    PubMed         Abstract available
    
    
15. SICURANZA A, Pacelli P, Santoni A, Raspadori D, et al
    Reply to "Peripheral blood CD26+ leukemic stem cells in chronic myeloid leukemia and tyrosine kinase inhibitor response: Questions remain!".
    Cancer. 2025;131:e70214.
    PubMed        
    
    
16. OZDEMIR ZN, Eskazan AE
    Peripheral blood CD26+ leukemic stem cells in chronic myeloid leukemia and tyrosine kinase inhibitor response: Questions remain!
    Cancer. 2025;131:e70215.
    PubMed        
    
    

    
    Eur J Haematol

17. CUNNINGHAM I, Fisher RA, Yang J, Guo Y, et al
    Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study.
    Eur J Haematol. 2025 Dec 10. doi: 10.1111/ejh.70051.
    PubMed         Abstract available
    
    

    
    Genomics

18. ZHANG S, Cheng W, Li T, Zhang Z, et al
    Super-enhancer-driven ELOVL5 promotes T-ALL progression through the MYC-SERBP1 pathway.
    Genomics. 2025;117:111111.
    PubMed         Abstract available
    
    

    
    Int J Hematol

19. TAKAOKA K, Tanariyakul M, Miyashita A, Nishimura Y, et al
    Epidemiological survey of potential familial myelodysplastic syndromes/acute myeloid leukemia in Hawaii.
    Int J Hematol. 2025 Dec 12. doi: 10.1007/s12185-025-04135.
    PubMed         Abstract available
    
    
20. SUZUKI K, Takaku T, Watanabe N, Iriyama N, et al
    Development of a blood test-based predictive scoring tool for treatment response in chronic myeloid leukemia.
    Int J Hematol. 2025 Dec 13. doi: 10.1007/s12185-025-04132.
    PubMed         Abstract available
    
    

    
    J Clin Oncol

21. JURCZAK W, Kwiatek M, Czyz J, Roberto de Mattos E, et al
    BRUIN CLL-313: Randomized Phase III Trial of Pirtobrutinib Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
    J Clin Oncol. 2025 Dec 9:JCO2502380. doi: 10.1200/JCO-25-02380.
    PubMed         Abstract available
    
    
22. DAVIDS MS
    BRUIN 313 and 314 Trials Open the Door for Noncovalent Bruton Tyrosine Kinase Inhibition as Initial Therapy for Chronic Lymphocytic Leukemia.
    J Clin Oncol. 2025 Dec 9:JCO2502691. doi: 10.1200/JCO-25-02691.
    PubMed        
    
    
23. WOYACH JA, Qiu L, Grosicki S, Wrobel T, et al
    Pirtobrutinib Versus Ibrutinib in Treatment-Naive and Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
    J Clin Oncol. 2025 Dec 7:JCO2502477. doi: 10.1200/JCO-25-02477.
    PubMed         Abstract available
    
    
24. GOTTSCHALK H, Moricke A, Conter V, Schrappe M, et al
    Reducing Daunorubicin in Induction Therapy in Children With B-Lineage ALL With Favorable Prognosis: Results of Phase III Trial AIEOP-BFM ALL 2009.
    J Clin Oncol. 2025;43:3739-3749.
    PubMed         Abstract available
    
    

    
    J Pediatr Hematol Oncol

25. CHENG CY, Wang DS, Yu CH, Jou ST, et al
    Preemptive NUDT15 Genotyping and Its Impact on Febrile Neutropenia in Pediatric Patients With Acute Lymphoblastic Leukemia in Taiwan.
    J Pediatr Hematol Oncol. 2025 Dec 9. doi: 10.1097/MPH.0000000000003154.
    PubMed         Abstract available
    
    
26. ARORA S, Danewa AS, Chakraborty S, Bhayana S, et al
    Excellent Outcomes of Hematopoietic Stem Cell Transplant for Pediatric High Risk and Relapsed Acute Myeloid Leukemia-A Decade Long Experience From Developing Nation.
    J Pediatr Hematol Oncol. 2025 Dec 2. doi: 10.1097/MPH.0000000000003151.
    PubMed         Abstract available
    
    

    
    Leuk Lymphoma

27. LI S, Chen G, Wang H, Guan W, et al
    Pre- and post-transplant extramedullary involvement in adult patients with t(8;21)(q22;q22) acute myeloid leukemia: incidence, risk factors and outcomes.
    Leuk Lymphoma. 2025 Dec 9:1-10. doi: 10.1080/10428194.2025.2598364.
    PubMed         Abstract available
    
    

    
    Leuk Res

28. HUNTER CJ, Chou A, Roeder H, Eighmy W, et al
    Isavuconazole provides effective and tolerable antifungal prophylaxis for patients with acute myeloid leukemia.
    Leuk Res. 2025;160:108144.
    PubMed         Abstract available
    
    

    
    Leukemia

29. DINARDO CD, Jen WY, Takahashi K, Kadia TM, et al
    Correction: Long term results of venetoclax combined with FLAG-IDA induction and consolidation for newly diagnosed and relapsed or refractory acute myeloid leukemia.
    Leukemia. 2025 Dec 10. doi: 10.1038/s41375-025-02827.
    PubMed        
    
    
30. HAAKSMA LH, Palmieri R, Reuvekamp T, Tettero JM, et al
    Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia.
    Leukemia. 2025 Dec 10. doi: 10.1038/s41375-025-02825.
    PubMed        
    
    
31. DEHGANE L, Mallet E, Brasseur C, Krzisch D, et al
    REL overexpression and sustained NF-kappaB signaling associated with 2p gain induce resistance to BTK inhibitors in Chronic Lymphocytic Leukemia.
    Leukemia. 2025 Dec 9. doi: 10.1038/s41375-025-02818.
    PubMed         Abstract available
    
    
32. HOCHHAUS A, Gale RP
    40 years of LEUKEMIA.
    Leukemia. 2025 Dec 8. doi: 10.1038/s41375-025-02840.
    PubMed        
    
    
33. MIKKELSEN T, Helenius M, Ampatzidou M, Attarbaschi A, et al
    Role of common host genome variants in Childhood Acute Lymphoblastic Leukemia.
    Leukemia. 2025 Dec 8. doi: 10.1038/s41375-025-02804.
    PubMed         Abstract available
    
    
34. STRUCKMAN NE, Koutsoumpli G, de Jong RCM, van der Lee DI, et al
    A T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia.
    Leukemia. 2025 Dec 12. doi: 10.1038/s41375-025-02817.
    PubMed         Abstract available
    
    

    
    N Engl J Med

35. CHIESA R, Georgiadis C, Rashed H, Preece R, et al
    Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia.
    N Engl J Med. 2025 Dec 8. doi: 10.1056/NEJMoa2505478.
    PubMed         Abstract available
    
    
36. AL-SAWAF O, Stumpf J, Zhang C, Simon F, et al
    Fixed-Duration versus Continuous Treatment for Chronic Lymphocytic Leukemia.
    N Engl J Med. 2025 Dec 6. doi: 10.1056/NEJMoa2515458.
    PubMed         Abstract available
    
    

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