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Leukemia

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Articles published in Leukemia
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November 2021

SHIMOMURA Y, Sobue T, Hirabayashi S, Kondo T, et al
Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia.
Leukemia. 2021 Nov 24. pii: 10.1038/s41375-021-01474.
PubMed Abstract available

HORAK P, Uhrig S, Witzel M, Gil-Farina I, et al
Publisher Correction: Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia.
Leukemia. 2021 Nov 16. pii: 10.1038/s41375-021-01364.
PubMed

ROESSNER PM, Seiffert M
Publisher Correction: T cells in chronic lymphocytic leukemia: guardians or drivers of disease?
Leukemia. 2021 Nov 16. pii: 10.1038/s41375-021-01362.
PubMed

WALTER RB, Hochhaus A, Gale RP
Elihu H. Estey, MD: leukemia expert, statistician, and gentle soul (July 15, 1946-October 8, 2021).
Leukemia. 2021 Nov 16. pii: 10.1038/s41375-021-01467.
PubMed

JEON S, de Smith AJ, Li S, Chen M, et al
Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia.
Leukemia. 2021 Nov 8. pii: 10.1038/s41375-021-01465.
PubMed

GADI D, Griffith A, Tyekucheva S, Wang Z, et al
A T cell inflammatory phenotype is associated with autoimmune toxicity of the PI3K inhibitor duvelisib in chronic lymphocytic leukemia.
Leukemia. 2021 Nov 6. pii: 10.1038/s41375-021-01441.
PubMed Abstract available

CATHELIN S, Sharon D, Subedi A, Cojocari D, et al
Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia.
Leukemia. 2021 Nov 6. pii: 10.1038/s41375-021-01468.
PubMed

YANG M, Pan Z, Huang K, Busche G, et al
A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation.
Leukemia. 2021 Nov 3. pii: 10.1038/s41375-021-01452.
PubMed Abstract available

KLOOS A, Mintzas K, Winckler L, Gabdoulline R, et al
Correction: Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.
Leukemia. 2021 Nov 2. pii: 10.1038/s41375-021-01459.
PubMed

BURKE MJ, Devidas M, Chen Z, Salzer WL, et al
Outcomes in adolescent and young adult patients (16 to 30 years) compared to younger patients treated for high-risk B-lymphoblastic leukemia: report from Children's Oncology Group Study AALL0232.
Leukemia. 2021 Nov 1. pii: 10.1038/s41375-021-01460.
PubMed Abstract available

October 2021

HEGDE S, Gasilina A, Wunderlich M, Lin Y, et al
Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.
Leukemia. 2021 Oct 28. pii: 10.1038/s41375-021-01455.
PubMed Abstract available

VAN DIJK AD, Griffen TL, Qiu YH, Hoff FW, et al
RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences.
Leukemia. 2021 Oct 8. pii: 10.1038/s41375-021-01438.
PubMed Abstract available

STETSON LC, Balasubramanian D, Ribeiro SP, Stefan T, et al
Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.
Leukemia. 2021;35:2799-2812.
PubMed Abstract available

GOURVEST M, De Clara E, Wu HC, Touriol C, et al
A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA.
Leukemia. 2021;35:2784-2798.
PubMed Abstract available

September 2021

BLIXT L, Bogdanovic G, Buggert M, Gao Y, et al
Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.
Leukemia. 2021 Sep 25. pii: 10.1038/s41375-021-01424.
PubMed Abstract available

SUD A, Law PJ, Houlston RS
The clinical utility of polygenic risk scores for chronic lymphocytic leukemia.
Leukemia. 2021 Sep 25. pii: 10.1038/s41375-021-01429.
PubMed

PAGOVICH OE, Stiles KM, Camilleri AE, Russo AR, et al
Gene therapy in a murine model of chronic eosinophilic leukemia-not otherwise specified (CEL-NOS).
Leukemia. 2021 Sep 20. pii: 10.1038/s41375-021-01400.
PubMed Abstract available

JAKOBCZYK H, Jiang Y, Debaize L, Soubise B, et al
ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.
Leukemia. 2021 Sep 17. pii: 10.1038/s41375-021-01409.
PubMed

TOKSVANG LN, Grell K, Nielsen SN, Nersting J, et al
DNA-TG and risk of sinusoidal obstruction syndrome in childhood acute lymphoblastic leukemia.
Leukemia. 2021 Sep 17. pii: 10.1038/s41375-021-01420.
PubMed

BOUCHER AC, Caldwell KJ, Crispino JD, Flerlage JE, et al
Clinical and biological aspects of myeloid leukemia in Down syndrome.
Leukemia. 2021 Sep 13. pii: 10.1038/s41375-021-01414.
PubMed Abstract available

TAMAKI K, Morishima S, Suzuki S, Shigenari A, et al
Full-length HLA sequencing in adult T cell leukemia-lymphoma uncovers multiple gene alterations.
Leukemia. 2021 Sep 13. pii: 10.1038/s41375-021-01403.
PubMed

ECKARDT JN, Middeke JM, Riechert S, Schmittmann T, et al
Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears.
Leukemia. 2021 Sep 8. pii: 10.1038/s41375-021-01408.
PubMed Abstract available

SAYGIN C, Hu E, Zhang P, Sher S, et al
Correction: Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.
Leukemia. 2021 Sep 3. pii: 10.1038/s41375-021-01398.
PubMed

TAGA T, Tanaka S, Hasegawa D, Terui K, et al
Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome.
Leukemia. 2021 Sep 1. pii: 10.1038/s41375-021-01397.
PubMed

ZHAO LP, Schell B, Sebert M, Kim R, et al
Prevalence of UBA1 mutations in MDS/CMML patients with systemic inflammatory and auto-immune disease.
Leukemia. 2021;35:2731-2733.
PubMed

ISSA GC, Ravandi F, DiNardo CD, Jabbour E, et al
Therapeutic implications of menin inhibition in acute leukemias.
Leukemia. 2021;35:2482-2495.
PubMed Abstract available

GIONFRIDDO I, Brunetti L, Mezzasoma F, Milano F, et al
Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.
Leukemia. 2021;35:2552-2562.
PubMed Abstract available

HEYES E, Schmidt L, Manhart G, Eder T, et al
Identification of gene targets of mutant C/EBPalpha reveals a critical role for MSI2 in CEBPA-mutated AML.
Leukemia. 2021;35:2526-2538.
PubMed Abstract available

ZHAO LP, Boy M, Azoulay C, Clappier E, et al
Genomic landscape of MDS/CMML associated with systemic inflammatory and autoimmune disease.
Leukemia. 2021;35:2720-2724.
PubMed

ROLLIG C, Serve H, Noppeney R, Hanoun M, et al
Sorafenib or placebo in patients with newly diagnosed acute myeloid leukaemia: long-term follow-up of the randomized controlled SORAML trial.
Leukemia. 2021;35:2517-2525.
PubMed Abstract available

AL HINAI ASA, Grob T, Rijken M, Kavelaars FG, et al
PPM1D mutations appear in complete remission after exposure to chemotherapy without predicting emerging AML relapse.
Leukemia. 2021;35:2693-2697.
PubMed

GODWIN CD, Laszlo GS, Fiorenza S, Garling EE, et al
Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy.
Leukemia. 2021;35:2496-2507.
PubMed Abstract available

August 2021

NIEDERKORN M, Ishikawa C, M Hueneman K, Bartram J, et al
The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia.
Leukemia. 2021 Aug 31. pii: 10.1038/s41375-021-01394.
PubMed Abstract available

YUAN S, Wang X, Hou S, Guo T, et al
PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression.
Leukemia. 2021 Aug 31. pii: 10.1038/s41375-021-01392.
PubMed Abstract available

RAFIQ S, McKenna SL, Muller S, Tschan MP, et al
Lysosomes in acute myeloid leukemia: potential therapeutic targets?
Leukemia. 2021 Aug 30. pii: 10.1038/s41375-021-01388.
PubMed Abstract available

OZTURK S, Paul Y, Afzal S, Gil-Farina I, et al
Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients.
Leukemia. 2021 Aug 20. pii: 10.1038/s41375-021-01381.
PubMed Abstract available

ZHANG XS, Gale RP, Huang XJ, Jiang Q, et al
Is the Sokal or EUTOS long-term survival (ELTS) score a better predictor of responses and outcomes in persons with chronic myeloid leukemia receiving tyrosine-kinase inhibitors?
Leukemia. 2021 Aug 19. pii: 10.1038/s41375-021-01387.
PubMed Abstract available

ANDRES-JENSEN L, Grell K, Rank CU, Albertsen BK, et al
Endothelial dysfunction and thromboembolism in children, adolescents, and young adults with acute lymphoblastic leukemia.
Leukemia. 2021 Aug 13. pii: 10.1038/s41375-021-01383.
PubMed Abstract available

XU Y, Mou J, Wang Y, Zhou W, et al
Regulatory T cells promote the stemness of leukemia stem cells through IL10 cytokine-related signaling pathway.
Leukemia. 2021 Aug 11. pii: 10.1038/s41375-021-01375.
PubMed Abstract available

YOSHINO S, Tanaka M, Sunami Y, Takahara T, et al
Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome.
Leukemia. 2021 Aug 11. pii: 10.1038/s41375-021-01384.
PubMed

TADMOR T, Benjamini O, Braester A, Rahav G, et al
Antibody persistence 100 days following the second dose of BNT162b mRNA Covid19 vaccine in patients with chronic lymphocytic leukemia.
Leukemia. 2021 Aug 10. pii: 10.1038/s41375-021-01380.
PubMed

LIU Q, Chan AKN, Chang WH, Yang L, et al
3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia.
Leukemia. 2021 Aug 9. pii: 10.1038/s41375-021-01378.
PubMed Abstract available

YAMAUCHI T, Miyawaki K, Semba Y, Takahashi M, et al
Targeting leukemia-specific dependence on the de novo purine synthesis pathway.
Leukemia. 2021 Aug 3. pii: 10.1038/s41375-021-01369.
PubMed Abstract available

PIKMAN Y, Ocasio-Martinez N, Alexe G, Dimitrov B, et al
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Leukemia. 2021 Aug 2. pii: 10.1038/s41375-021-01361.
PubMed Abstract available

BACCARANI M, Gale RP
Why chronic myeloid leukaemia cannot be cured by tyrosine kinase-inhibitors.
Leukemia. 2021;35:2199-2204.
PubMed

POLIVKOVA V, Benesova A, Zizkova H, Koblihova J, et al
Sensitivity and reliability of DNA-based mutation analysis by allele-specific digital PCR to follow resistant BCR-ABL1-positive cells.
Leukemia. 2021;35:2419-2423.
PubMed

RICHTER J, Lubking A, Soderlund S, Lotfi K, et al
Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR-final report from AFTER-SKI.
Leukemia. 2021;35:2416-2418.
PubMed

RACA G, Abdel-Azim H, Yue F, Broach J, et al
Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children-a novel health disparity.
Leukemia. 2021;35:2399-2402.
PubMed

ABDULLA H, Vo A, Shields BJ, Davies TJ, et al
T-ALL can evolve to oncogene independence.
Leukemia. 2021;35:2205-2219.
PubMed Abstract available

GUILHOT F, Rigal-Huguet F, Guilhot J, Guerci-Bresler AP, et al
Long-term outcome of imatinib 400 mg compared to imatinib 600 mg or imatinib 400 mg daily in combination with cytarabine or pegylated interferon alpha 2a for chronic myeloid leukaemia: results from the French SPIRIT phase III randomised trial.
Leukemia. 2021;35:2332-2345.
PubMed Abstract available

FANG X, Xu S, Zhang Y, Xu J, et al
Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish.
Leukemia. 2021;35:2299-2310.
PubMed Abstract available

TODISCO G, Creignou M, Galli A, Guglielmelli P, et al
Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2(P95)-mutated neoplasms.
Leukemia. 2021;35:2371-2381.
PubMed Abstract available

July 2021

RUCKER FG, Du L, Luck TJ, Benner A, et al
Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results.
Leukemia. 2021 Jul 28. pii: 10.1038/s41375-021-01323.
PubMed Abstract available

ZHAO XY, Xu ZL, Mo XD, Chen YH, et al
Preemptive donor-derived anti-CD19 CAR T-cell infusion showed a promising anti-leukemia effect against relapse in MRD-positive B-ALL after allogeneic hematopoietic stem cell transplantation.
Leukemia. 2021 Jul 20. pii: 10.1038/s41375-021-01351.
PubMed

KLEINSTERN G, Weinberg JB, Parikh SA, Braggio E, et al
Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.
Leukemia. 2021 Jul 20. pii: 10.1038/s41375-021-01344.
PubMed Abstract available

VAN DER WERF I, Wojtuszkiewicz A, Yao H, Sciarrillo R, et al
Author Correction: SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia.
Leukemia. 2021 Jul 8. pii: 10.1038/s41375-021-01340.
PubMed

BOER JM, Valsecchi MG, Hormann FM, Antic Z, et al
Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study.
Leukemia. 2021 Jul 1. pii: 10.1038/s41375-021-01333.
PubMed

MARTELLI AM, Evangelisti C, Paganelli F, Chiarini F, et al
GSK-3: a multifaceted player in acute leukemias.
Leukemia. 2021;35:1829-1842.
PubMed Abstract available

SEKERES MA, Watts J, Radinoff A, Sangerman MA, et al
Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AML.
Leukemia. 2021;35:2119-2124.
PubMed

MODVIG S, Hallbook H, Madsen HO, Siitonen S, et al
Value of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting.
Leukemia. 2021;35:1894-1906.
PubMed Abstract available

ESTRUCH M, Reckzeh K, Vittori C, Centio A, et al
Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy.
Leukemia. 2021;35:2030-2042.
PubMed Abstract available

LIU H, Xuan L, Lin R, Deng L, et al
A new pre-emptive TKIs strategy for preventing relapse based on BCR/ABL monitoring for Ph+ALL undergoing allo-HCT: a prospective clinical cohort study.
Leukemia. 2021;35:2054-2063.
PubMed Abstract available

TOMII T, Imamura T, Tanaka K, Kato I, et al
Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model.
Leukemia. 2021;35:2092-2096.
PubMed

RUMMELT C, Gorantla SP, Meggendorfer M, Charlet A, et al
Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo.
Leukemia. 2021;35:2017-2029.
PubMed Abstract available

NAMBURI S, Broxmeyer HE, Hong CS, Whiteside TL, et al
DPP4(+) exosomes in AML patients' plasma suppress proliferation of hematopoietic progenitor cells.
Leukemia. 2021;35:1925-1932.
PubMed Abstract available

June 2021

SIMONETTI G, Mengucci C, Padella A, Fonzi E, et al
Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin/DNA damage mutations.
Leukemia. 2021 Jun 30. pii: 10.1038/s41375-021-01318.
PubMed Abstract available

THOMAS KR, Allenspach EJ, Camp ND, Wray-Dutra MN, et al
Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.
Leukemia. 2021 Jun 30. pii: 10.1038/s41375-021-01326.
PubMed Abstract available

TAJ MM, Moorman AV, Hamadeh L, Petit A, et al
Prognostic value of Oncogenetic mutations in pediatric T Acute Lymphoblastic Leukemia: a comparison of UKALL2003 and FRALLE2000T protocols.
Leukemia. 2021 Jun 28. pii: 10.1038/s41375-021-01334.
PubMed

BEHNERT A, Meyer J, Parsa JY, Hechmer A, et al
Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples.
Leukemia. 2021 Jun 28. pii: 10.1038/s41375-021-01331.
PubMed

RENNEVILLE A, Patnaik MM, Chan O, Padron E, et al
Increasing recognition and emerging therapies argue for dedicated clinical trials in chronic myelomonocytic leukemia.
Leukemia. 2021 Jun 26. pii: 10.1038/s41375-021-01330.
PubMed Abstract available

TOKSVANG LN, Grell K, Nersting J, Degn M, et al
DNA-thioguanine concentration and relapse risk in children and young adults with acute lymphoblastic leukemia: an IPD meta-analysis.
Leukemia. 2021 Jun 26. pii: 10.1038/s41375-021-01182.
PubMed Abstract available

SHORT NJ, Kantarjian H, Jabbour E
Optimizing the treatment of acute lymphoblastic leukemia in younger and older adults: new drugs and evolving paradigms.
Leukemia. 2021 Jun 25. pii: 10.1038/s41375-021-01277.
PubMed Abstract available

WIERDA WG, Rawstron A, Cymbalista F, Badoux X, et al
Measurable residual disease in chronic lymphocytic leukemia: expert review and consensus recommendations.
Leukemia. 2021 Jun 24. pii: 10.1038/s41375-021-01241.
PubMed Abstract available

ABDALLAH MG, Niibori-Nambu A, Morii M, Yokomizo T, et al
RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner.
Leukemia. 2021 Jun 19. pii: 10.1038/s41375-021-01268.
PubMed

NISHIDA Y, Zhao R, Heese LE, Akiyama H, et al
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Leukemia. 2021 Jun 14. pii: 10.1038/s41375-021-01308.
PubMed Abstract available

LI Z, Jiang N, Lim EH, Chin WHN, et al
Role of transcriptome sequencing in clinical diagnosis of B-cell acute lymphoblastic leukemia.
Leukemia. 2021 Jun 10. pii: 10.1038/s41375-021-01185.
PubMed

KANTARJIAN HM, Hughes TP, Larson RA, Kim DW, et al
Correction to: Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis.
Leukemia. 2021 Jun 9. pii: 10.1038/s41375-021-01306.
PubMed

DHAKAL B, Patel S, Girnius S, Bachegowda L, et al
Correction to: Hematopoietic cell transplantation utilization and outcomes for primary plasma cell leukemia in the current era.
Leukemia. 2021 Jun 5. pii: 10.1038/s41375-021-01304.
PubMed

WIEDUWILT MJ, Stock W, Advani A, Luger S, et al
Correction: Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: an
Leukemia. 2021 Jun 4. pii: 10.1038/s41375-021-01303.
PubMed

KIM D, Park G, Huuhtanen J, Ghimire B, et al
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation.
Leukemia. 2021 Jun 1. pii: 10.1038/s41375-021-01296.
PubMed Abstract available

MAYANSKIY N, Luchkina P, Fedorova N, Lebedin Y, et al
Seroconversion and dynamics of the anti-SARS-CoV-2 antibody response related to a hospital COVID-19 outbreak among pediatric oncology patients.
Leukemia. 2021;35:1820-1822.
PubMed

GURNARI C, Durrani J, Pagliuca S, Kishtagari A, et al
Novel invariant features of Good syndrome.
Leukemia. 2021;35:1792-1796.
PubMed

ARVINDAM US, van Hauten PMM, Schirm D, Schaap N, et al
A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells.
Leukemia. 2021;35:1586-1596.
PubMed Abstract available

MARTINEZ-CUADRON D, Serrano J, Gil C, Tormo M, et al
Evolving treatment patterns and outcomes in older patients (>/=60 years) with AML: changing everything to change nothing?
Leukemia. 2021;35:1571-1585.
PubMed Abstract available

ZHANG C, Wang XQ, Zhang RL, Liu F, et al
Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant.
Leukemia. 2021;35:1563-1570.
PubMed Abstract available

MURRAY HC, Enjeti AK, Kahl RGS, Flanagan HM, et al
Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia.
Leukemia. 2021;35:1782-1787.
PubMed

DE HAAS V, Pieters R, van der Sluijs-Gelling AJ, Zwaan CM, et al
Flowcytometric evaluation of cerebrospinal fluid in childhood ALL identifies CNS involvement better then conventional cytomorphology.
Leukemia. 2021;35:1773-1776.
PubMed

May 2021

SAYGIN C, Hu E, Zhang P, Sher S, et al
Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.
Leukemia. 2021 May 21. pii: 10.1038/s41375-021-01295.
PubMed Abstract available

VAN DER ZWET JCG, Buijs-Gladdines JGCAM, Cordo' V, Debets DO, et al
MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance.
Leukemia. 2021 May 18. pii: 10.1038/s41375-021-01291.
PubMed Abstract available

JAIN N, Thompson P, Burger J, Ferrajoli A, et al
Ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab (iFCG) regimen for chronic lymphocytic leukemia (CLL) with mutated IGHV and without TP53 aberrations.
Leukemia. 2021 May 18. pii: 10.1038/s41375-021-01280.
PubMed Abstract available

BRECCIA M, Pregno P, Castagnetti F, Bonifacio M, et al
Eutos long-term survival score discriminates different Sokal score categories in chronic myeloid leukemia patients, showing better survival prediction. Analysis of the GIMEMA CML observational study.
Leukemia. 2021 May 17. pii: 10.1038/s41375-021-01292.
PubMed

CARRATT SA, Braun TP, Coblentz C, Schonrock Z, et al
Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia.
Leukemia. 2021 May 17. pii: 10.1038/s41375-021-01278.
PubMed Abstract available

DOURTHE ME, Rabian F, Yakouben K, Chevillon F, et al
Determinants of CD19-positive vs CD19-negative relapse after tisagenlecleucel for B-cell acute lymphoblastic leukemia.
Leukemia. 2021 May 17. pii: 10.1038/s41375-021-01281.
PubMed Abstract available

VAN DER WERF I, Wojtuszkiewicz A, Yao H, Sciarrillo R, et al
SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia.
Leukemia. 2021 May 17. pii: 10.1038/s41375-021-01273.
PubMed

ROEKER LE, Knorr DA, Thompson MC, Nivar M, et al
COVID-19 vaccine efficacy in patients with chronic lymphocytic leukemia.
Leukemia. 2021 May 13. pii: 10.1038/s41375-021-01270.
PubMed

HUGHES TP, Clementino NCD, Fominykh M, Lipton JH, et al
Long-term treatment-free remission in patients with chronic myeloid leukemia after second-line nilotinib: ENESTop 5-year update.
Leukemia. 2021 May 12. pii: 10.1038/s41375-021-01260.
PubMed Abstract available

YAMAGATA K, Shino M, Aikawa Y, Fujita S, et al
Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia.
Leukemia. 2021 May 9. pii: 10.1038/s41375-021-01244.
PubMed Abstract available

BRAVO-NAVAS S, Yanez L, Romon I, Briz M, et al
Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
Leukemia. 2021 May 8. pii: 10.1038/s41375-021-01184.
PubMed

STOMPER J, Rotondo JC, Greve G, Lubbert M, et al
Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies.
Leukemia. 2021 May 6. pii: 10.1038/s41375-021-01218.
PubMed Abstract available

DAVER N, Alotaibi AS, Bucklein V, Subklewe M, et al
T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments.
Leukemia. 2021 May 5. pii: 10.1038/s41375-021-01253.
PubMed Abstract available

GREVER M, Andritsos L, Banerji V, Barrientos JC, et al
Hairy cell leukemia and COVID-19 adaptation of treatment guidelines.
Leukemia. 2021 May 4. pii: 10.1038/s41375-021-01257.
PubMed Abstract available

HARRISON CJ
Prevention of childhood leukaemia by lifestyle changes.
Leukemia. 2021;35:1265-1266.
PubMed

GREAVES M, Cazzaniga V, Ford A
Can we prevent childhood Leukaemia?
Leukemia. 2021;35:1258-1264.
PubMed

BERG JL, Perfler B, Hatzl S, Uhl B, et al
EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Leukemia. 2021;35:1521-1526.
PubMed

LARGEAUD L, Cornillet-Lefebvre P, Hamel JF, Dumas PY, et al
Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study.
Leukemia. 2021;35:1291-1300.
PubMed Abstract available

April 2021

KIEHLMEIER S, Rafiee MR, Bakr A, Mika J, et al
Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia.
Leukemia. 2021 Apr 28. pii: 10.1038/s41375-021-01235.
PubMed Abstract available

BHM JW, Sia KCS, Jones C, Evans K, et al
Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia.
Leukemia. 2021 Apr 24. pii: 10.1038/s41375-021-01248.
PubMed Abstract available

GUNNARSSON R, Yang M, Olsson-Arvidsson L, Biloglav A, et al
Single base substitution mutational signatures in pediatric acute myeloid leukemia based on whole genome sequencing.
Leukemia. 2021 Apr 16. pii: 10.1038/s41375-021-01242.
PubMed

BROWN PA, Kairalla JA, Hilden JM, Dreyer ZE, et al
Correction to: FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children's Oncology Group trial AALL0631.
Leukemia. 2021 Apr 12. pii: 10.1038/s41375-021-01245.
PubMed

CARRENO-TARRAGONA G, Varghese LN, Sebastian E, Galvez E, et al
A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline.
Leukemia. 2021 Apr 12. pii: 10.1038/s41375-021-01239.
PubMed

MONTALBAN-BRAVO G, Hammond D, DiNardo CD, Konopleva M, et al
Activity of venetoclax-based therapy in chronic myelomonocytic leukemia.
Leukemia. 2021 Apr 12. pii: 10.1038/s41375-021-01240.
PubMed

HSIEH YC, Kirschner K, Copland M
Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape.
Leukemia. 2021 Apr 8. pii: 10.1038/s41375-021-01238.
PubMed Abstract available

TAMBARO FP, Singh H, Jones E, Rytting M, et al
Autologous CD33-CAR-T cells for treatment of relapsed/refractory acute myelogenous leukemia.
Leukemia. 2021 Apr 8. pii: 10.1038/s41375-021-01232.
PubMed

SCHLEISS C, Carapito R, Fornecker LM, Muller L, et al
Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia.
Leukemia. 2021 Apr 8. pii: 10.1038/s41375-021-01221.
PubMed Abstract available

BATTA K, Bossenbroek HM, Pemmaraju N, Wilks DP, et al
Divergent clonal evolution of blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia from a shared TET2-mutated origin.
Leukemia. 2021 Apr 8. pii: 10.1038/s41375-021-01228.
PubMed

HU GH, Zhao XY, Zuo YX, Chang YJ, et al
Unmanipulated haploidentical hematopoietic stem cell transplantation is an excellent option for children and young adult relapsed/refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia after CAR-T-cell therapy.
Leukemia. 2021 Apr 6. pii: 10.1038/s41375-021-01236.
PubMed Abstract available

MILLER CR, Huang Y, Ruppert AS, Labanowska J, et al
Significance of chromosome 2p gain in ibrutinib-treated chronic lymphocytic leukemia patients.
Leukemia. 2021 Apr 5. pii: 10.1038/s41375-021-01237.
PubMed

DAVIDS MS, Fisher DC, Tyekucheva S, McDonough M, et al
A phase 1b/2 study of duvelisib in combination with FCR (DFCR) for frontline therapy for younger CLL patients.
Leukemia. 2021;35:1064-1072.
PubMed Abstract available

REEDIJK AMJ, Coebergh JWW, de Groot-Kruseman HA, van der Sluis IM, et al
Progress against childhood and adolescent acute lymphoblastic leukaemia in the Netherlands, 1990-2015.
Leukemia. 2021;35:1001-1011.
PubMed Abstract available

LONTOS K, Yabes JG, Farah RJ, Boyiadzis M, et al
Impact of upfront chemotherapy on overall survival in isolated myeloid sarcoma.
Leukemia. 2021;35:1193-1196.
PubMed

AU YZ, Gu M, De Braekeleer E, Gozdecka M, et al
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
Leukemia. 2021;35:1012-1022.
PubMed Abstract available

March 2021

EISENWORT G, Sadovnik I, Keller A, Ivanov D, et al
Phenotypic characterization of leukemia-initiating stem cells in chronic myelomonocytic leukemia.
Leukemia. 2021 Mar 30. pii: 10.1038/s41375-021-01227.
PubMed Abstract available

WIEDUWILT MJ, Stock W, Advani A, Luger S, et al
Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: analysis from
Leukemia. 2021 Mar 30. pii: 10.1038/s41375-021-01213.
PubMed Abstract available

GRANDITS AM, Nguyen CH, Schlerka A, Hackl H, et al
Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
Leukemia. 2021 Mar 29. pii: 10.1038/s41375-021-01224.
PubMed Abstract available

DINARDO CD, Stein EM, Pigneux A, Altman JK, et al
Outcomes of patients with IDH1-mutant relapsed or refractory acute myeloid leukemia receiving ivosidenib who proceeded to hematopoietic stem cell transplant.
Leukemia. 2021 Mar 26. pii: 10.1038/s41375-021-01229.
PubMed

WALTER RB, Ofran Y, Wierzbowska A, Ravandi F, et al
Measurable residual disease as a biomarker in acute myeloid leukemia: theoretical and practical considerations.
Leukemia. 2021 Mar 23. pii: 10.1038/s41375-021-01230.
PubMed Abstract available

RIVAS JR, Liu Y, Alhakeem SS, Eckenrode JM, et al
Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia.
Leukemia. 2021 Mar 17. pii: 10.1038/s41375-021-01217.
PubMed Abstract available

LLAO-CID L, Roessner PM, Chapaprieta V, Ozturk S, et al
EOMES is essential for antitumor activity of CD8(+) T cells in chronic lymphocytic leukemia.
Leukemia. 2021 Mar 17. pii: 10.1038/s41375-021-01198.
PubMed Abstract available

TIACCI E, De Carolis L, Simonetti E, Merluzzi M, et al
Safety and efficacy of the BRAF inhibitor dabrafenib in relapsed or refractory hairy cell leukemia: a pilot phase-2 clinical trial.
Leukemia. 2021 Mar 17. pii: 10.1038/s41375-021-01210.
PubMed

DIEDRICH JD, Dong Q, Ferguson DC, Bergeron BP, et al
Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks.
Leukemia. 2021 Mar 13. pii: 10.1038/s41375-021-01209.
PubMed Abstract available

STANULLA M, Schaeffeler E, Moricke A, Buchmann S, et al
Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia.
Leukemia. 2021 Mar 13. pii: 10.1038/s41375-021-01203.
PubMed Abstract available

CHAN O, Renneville A, Padron E
Chronic myelomonocytic leukemia diagnosis and management.
Leukemia. 2021 Mar 13. pii: 10.1038/s41375-021-01207.
PubMed Abstract available

HE X, Feng Z, Ma J, Zhang X, et al
CAR T cells targeting CD13 controllably induce eradication of acute myeloid leukemia with a single domain antibody switch.
Leukemia. 2021 Mar 12. pii: 10.1038/s41375-021-01208.
PubMed

RADICH JP, Hochhaus A, Masszi T, Hellmann A, et al
Treatment-free remission following frontline nilotinib in patients with chronic phase chronic myeloid leukemia: 5-year update of the ENESTfreedom trial.
Leukemia. 2021 Mar 11. pii: 10.1038/s41375-021-01205.
PubMed Abstract available

PERICA K, Flynn J, Curran KJ, Rivere I, et al
Impact of bridging chemotherapy on clinical outcome of CD19 CAR T therapy in adult acute lymphoblastic leukemia.
Leukemia. 2021 Mar 8. pii: 10.1038/s41375-021-01196.
PubMed

YAMATO G, Deguchi T, Terui K, Toki T, et al
Predictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome.
Leukemia. 2021 Mar 3. pii: 10.1038/s41375-021-01171.
PubMed

KAZIANKA L, Staber PB
Blood cancer driver Musashi-2 as therapeutic target in chronic lymphocytic leukemia.
Leukemia. 2021 Mar 2. pii: 10.1038/s41375-021-01144.
PubMed

LARSON RA, Mandrekar SJ, Huebner LJ, Sanford BL, et al
Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial.
Leukemia. 2021 Mar 2. pii: 10.1038/s41375-021-01179.
PubMed Abstract available

BOND J, Krzywon A, Lhermitte L, Roumier C, et al
A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis.
Leukemia. 2021;35:724-736.
PubMed Abstract available

YOU X, Chang YI, Kong G, Ranheim EA, et al
Gata2 -77 enhancer regulates adult hematopoietic stem cell survival.
Leukemia. 2021;35:901-905.
PubMed

DE-MORGAN A, Meggendorfer M, Haferlach C, Shlush L, et al
Male predominance in AML is associated with specific preleukemic mutations.
Leukemia. 2021;35:867-870.
PubMed

WASS M, Gollner S, Besenbeck B, Schlenk RF, et al
A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy.
Leukemia. 2021;35:701-711.
PubMed Abstract available

February 2021

KOVALOVSKY D, Yoon JH, Cyr MG, Simon S, et al
Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia.
Leukemia. 2021 Feb 25. pii: 10.1038/s41375-021-01188.
PubMed Abstract available

BROWN PA, Kairalla JA, Hilden JM, Dreyer ZE, et al
FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children's Oncology Group trial AALL0631.
Leukemia. 2021 Feb 23. pii: 10.1038/s41375-021-01177.
PubMed Abstract available

MAFFEI R, Fiorcari S, Benatti S, Atene CG, et al
IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK.
Leukemia. 2021 Feb 23. pii: 10.1038/s41375-021-01178.
PubMed Abstract available

VAN DER VELDEN VHJ, Bruggemann M, Cazzaniga G, Scheijen B, et al
Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study.
Leukemia. 2021 Feb 19. pii: 10.1038/s41375-021-01154.
PubMed

ECTOR GICG, Visser O, Posthuma EFM, Westerweel PE, et al
Conditional relative survival among adult patients with chronic myeloid leukemia in the tyrosine kinase inhibitor era: a population-based study in the Netherlands.
Leukemia. 2021 Feb 18. pii: 10.1038/s41375-021-01174.
PubMed

ROTBAIN EC, Niemann CU, Rostgaard K, da Cunha-Bang C, et al
Mapping comorbidity in chronic lymphocytic leukemia: impact of individual comorbidities on treatment, mortality, and causes of death.
Leukemia. 2021 Feb 18. pii: 10.1038/s41375-021-01156.
PubMed Abstract available

TAGA T, Tanaka S, Hasegawa D, Terui K, et al
Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome.
Leukemia. 2021 Feb 15. pii: 10.1038/s41375-021-01157.
PubMed Abstract available

CUCCHI DGJ, Polak TB, Ossenkoppele GJ, Uyl-De Groot CA, et al
Two decades of targeted therapies in acute myeloid leukemia.
Leukemia. 2021 Feb 15. pii: 10.1038/s41375-021-01164.
PubMed Abstract available

NGUYEN LXT, Zhang B, Hoang DH, Zhao D, et al
Cytoplasmic DROSHA and non-canonical mechanisms of MiR-155 biogenesis in FLT3-ITD acute myeloid leukemia.
Leukemia. 2021 Feb 15. pii: 10.1038/s41375-021-01166.
PubMed Abstract available

RAPAPORT F, Neelamraju Y, Baslan T, Hassane D, et al
Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.
Leukemia. 2021 Feb 12. pii: 10.1038/s41375-021-01153.
PubMed

CHUN S, Kim HY, Kim HJ, Koo HH, et al
Low CtBP2 expression is associated with a stem cell-like signature and adverse clinical outcome in childhood B-cell lymphoblastic leukemia.
Leukemia. 2021 Feb 12. pii: 10.1038/s41375-021-01151.
PubMed

WINTER G, Kirschner-Schwabe R, Groeneveld-Krentz S, Escherich G, et al
Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome.
Leukemia. 2021 Feb 12. pii: 10.1038/s41375-021-01163.
PubMed

DEL GALY AS, Marouf A, Raffoux E, Robin M, et al
Correction to: Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality.
Leukemia. 2021 Feb 9. pii: 10.1038/s41375-020-01112.
PubMed

PATKAR N, Kakirde C, Shaikh AF, Salve R, et al
Clinical impact of panel-based error-corrected next generation sequencing versus flow cytometry to detect measurable residual disease (MRD) in acute myeloid leukemia (AML).
Leukemia. 2021 Feb 8. pii: 10.1038/s41375-021-01131.
PubMed Abstract available

LIBBRECHT C, Xie HM, Kingsley MC, Haladyna JN, et al
Menin is necessary for long term maintenance of meningioma-1 driven leukemia.
Leukemia. 2021 Feb 4. pii: 10.1038/s41375-021-01146.
PubMed Abstract available

ESTEVE J, Giebel S, Labopin M, Czerw T, et al
Allogeneic hematopoietic stem cell transplantation for adult patients with t(4;11)(q21;q23) KMT2A/AFF1 B-cell precursor acute lymphoblastic leukemia in first complete remission: impact of pretransplant measurable residual disease (MRD) status. An anal
Leukemia. 2021 Feb 4. pii: 10.1038/s41375-021-01135.
PubMed Abstract available

BAUMANN T, Moia R, Gaidano G, Delgado J, et al
Lymphocyte doubling time in chronic lymphocytic leukemia modern era: a real-life study in 848 unselected patients.
Leukemia. 2021 Feb 4. pii: 10.1038/s41375-021-01149.
PubMed Abstract available

WEI AH, Ribera JM, Larson RA, Ritchie D, et al
Biomarkers associated with blinatumomab outcomes in acute lymphoblastic leukemia.
Leukemia. 2021 Feb 4. pii: 10.1038/s41375-020-01089.
PubMed Abstract available

GE Z, Song C, Ding Y, Tan BH, et al
Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia.
Leukemia. 2021 Feb 2. pii: 10.1038/s41375-021-01132.
PubMed Abstract available

ROESSNER PM, Llao Cid L, Lupar E, Roider T, et al
EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4(+) T cells in chronic lymphocytic leukemia.
Leukemia. 2021 Feb 1. pii: 10.1038/s41375-021-01136.
PubMed Abstract available

PAIVA B, Vidriales MB, Sempere A, Tarin F, et al
Impact of measurable residual disease by decentralized flow cytometry: a PETHEMA real-world study in 1076 patients with acute myeloid leukemia.
Leukemia. 2021 Feb 1. pii: 10.1038/s41375-021-01126.
PubMed Abstract available

GANESAN R, Chennupati V, Ramachandran B, Hansen MR, et al
Selective recruitment of gammadelta T cells by a bispecific antibody for the treatment of acute myeloid leukemia.
Leukemia. 2021 Feb 1. pii: 10.1038/s41375-021-01122.
PubMed Abstract available

NAIR R, Salinas-Illarena A, Baldauf HM
New strategies to treat AML: novel insights into AML survival pathways and combination therapies.
Leukemia. 2021;35:299-311.
PubMed Abstract available

YANG S, Varghese AM, Sood N, Chiattone C, et al
Ethnic and geographic diversity of chronic lymphocytic leukaemia.
Leukemia. 2021;35:433-439.
PubMed Abstract available

LE Q, Hadland B, Meshinchi S, Bernstein I, et al
Notch blockade overcomes endothelial cell-mediated resistance of FLT3/ITD-positive AML progenitors to AC220 treatment.
Leukemia. 2021;35:601-605.
PubMed

ZHAO J, Sui P, Wu B, Chen A, et al
Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model.
Leukemia. 2021;35:595-600.
PubMed

GHASEMI R, Struthers H, Wilson ER, Spencer DH, et al
Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells.
Leukemia. 2021;35:404-416.
PubMed Abstract available

January 2021

PALACIOS F, Yan XJ, Ferrer G, Chen SS, et al
Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target.
Leukemia. 2021 Jan 27. pii: 10.1038/s41375-020-01115.
PubMed Abstract available

BHATT NS, Baassiri MJ, Liu W, Bhakta N, et al
Late outcomes in survivors of childhood acute myeloid leukemia: a report from the St. Jude Lifetime Cohort Study.
Leukemia. 2021 Jan 25. pii: 10.1038/s41375-021-01134.
PubMed Abstract available

YI S, Yan Y, Jin M, Xiong W, et al
High incidence of MYD88 and KMT2D mutations in Chinese with chronic lymphocytic leukemia.
Leukemia. 2021 Jan 22. pii: 10.1038/s41375-021-01124.
PubMed

GOEMANS BF, Noort S, Blink M, Wang YD, et al
Sensitive GATA1 mutation screening reliably identifies neonates with Down syndrome at risk for myeloid leukemia.
Leukemia. 2021 Jan 22. pii: 10.1038/s41375-021-01128.
PubMed

BENMEBAREK MR, Cadilha BL, Herrmann M, Lesch S, et al
A modular and controllable T cell therapy platform for acute myeloid leukemia.
Leukemia. 2021 Jan 7. pii: 10.1038/s41375-020-01109.
PubMed Abstract available

KANTARJIAN HM, Hughes TP, Larson RA, Kim DW, et al
Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis.
Leukemia. 2021 Jan 7. pii: 10.1038/s41375-020-01111.
PubMed Abstract available

O'NIONS J, Muir L, Zheng J, Rees-Spear C, et al
SARS-CoV-2 antibody responses in patients with acute leukaemia.
Leukemia. 2021;35:289-292.
PubMed

SWOBODA DM, Ali NA, Chan O, Padron E, et al
PTPN11 mutations are associated with poor outcomes across myeloid malignancies.
Leukemia. 2021;35:286-288.
PubMed

NOFRINI V, Matteucci C, Pellanera F, Gorello P, et al
Activating somatic and germline TERT promoter variants in myeloid malignancies.
Leukemia. 2021;35:274-278.
PubMed

NAGATE Y, Ezoe S, Fujita J, Okuzaki D, et al
Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function.
Leukemia. 2021;35:107-118.
PubMed Abstract available

December 2020

WALTER RB, Appelbaum FR, Estey EH
Optimal dosing of cytarabine in induction and post-remission therapy of acute myeloid leukemia.
Leukemia. 2020 Dec 16. pii: 10.1038/s41375-020-01110.
PubMed

TIRADO-GONZALEZ I, Czlonka E, Nevmerzhitskaya A, Soetopo D, et al
Correction: CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.
Leukemia. 2020 Dec 1. pii: 10.1038/s41375-020-01071.
PubMed Abstract available

DE BARRIOS O, Galaras A, Trincado JL, Azagra A, et al
HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.
Leukemia. 2020 Dec 1. pii: 10.1038/s41375-020-01097.
PubMed

SOVERINI S, Martelli M, Bavaro L, De Benedittis C, et al
BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analyzed by NGS.
Leukemia. 2020 Dec 1. pii: 10.1038/s41375-020-01098.
PubMed

VU TT, Stolzel F, Wang KW, Rollig C, et al
miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia.
Leukemia. 2020 Dec 1. pii: 10.1038/s41375-020-01095.
PubMed Abstract available

BOND DA, Huang Y, Fisher JL, Ruppert AS, et al
Second cancer incidence in CLL patients receiving BTK inhibitors.
Leukemia. 2020;34:3197-3205.
PubMed Abstract available

PAN J, Tan Y, Deng B, Tong C, et al
Frequent occurrence of CD19-negative relapse after CD19 CAR T and consolidation therapy in 14 TP53-mutated r/r B-ALL children.
Leukemia. 2020;34:3382-3387.
PubMed

DUN MD, Mannan A, Rigby CJ, Butler S, et al
Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia.
Leukemia. 2020;34:3393-3397.
PubMed

November 2020

EMADI A, Kapadia B, Bollino D, Bhandary B, et al
Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia.
Leukemia. 2020 Nov 16. pii: 10.1038/s41375-020-01080.
PubMed Abstract available

ESTEY E
New treatments for acute myeloid leukemia: how much has changed?
Leukemia. 2020 Nov 12. pii: 10.1038/s41375-020-01084.
PubMed

ADNAN-AWAD S, Kim D, Hohtari H, Javarappa KK, et al
Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets.
Leukemia. 2020 Nov 9. pii: 10.1038/s41375-020-01082.
PubMed Abstract available

SPORTOLETTI P, Sorcini D, Guzman AG, Reyes JM, et al
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Leukemia. 2020 Nov 6. pii: 10.1038/s41375-020-01075.
PubMed Abstract available

ELCHEVA IA, Spiegelman VS
Targeting RNA-binding proteins in acute and chronic leukemia.
Leukemia. 2020 Nov 4. pii: 10.1038/s41375-020-01066.
PubMed Abstract available

KOMROKJI RS, Ali NA, Sallman D, Padron E, et al
Characterization of myelodysplastic syndromes (MDS) with T-cell large granular lymphocyte proliferations (LGL).
Leukemia. 2020;34:3097-3099.
PubMed

ZHAO H, Deininger MW
Declaration of Bcr-Abl1 independence.
Leukemia. 2020;34:2827-2836.
PubMed

HEUSER M, Palmisiano N, Mantzaris I, Mims A, et al
Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results.
Leukemia. 2020;34:2903-2913.
PubMed Abstract available

VENKATARAMAN V, Casey KS, Onozato M, Cin PD, et al
Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy.
Leukemia. 2020;34:3050-3054.
PubMed

LIBERT D, Yuan CM, Masih KE, Galera P, et al
Serial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy.
Leukemia. 2020;34:3064-3069.
PubMed

October 2020

ZENT CS, Brady MT, Delage C, Strawderman M, et al
Short term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial BTK inhibitor therapy for CLL or lymphoplasmacytic lymphoma.
Leukemia. 2020 Oct 30. pii: 10.1038/s41375-020-01074.
PubMed

CAPO-CHICHI JM, Kagotho E, Nayyar R, Zhao D, et al
Systemic mastocytosis with acute myeloid leukemia occurs from mutually exclusive clones expressing KIT(D816V) and FLT3-ITD.
Leukemia. 2020 Oct 26. pii: 10.1038/s41375-020-01073.
PubMed

PUTZER S, Varghese L, von Jan J, Braun T, et al
Corrections: Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine.
Leukemia. 2020 Oct 23. pii: 10.1038/s41375-020-01067.
PubMed Abstract available

HASAN MK, Ghia EM, Rassenti LZ, Widhopf GF 2nd, et al
Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism.
Leukemia. 2020 Oct 23. pii: 10.1038/s41375-020-01055.
PubMed Abstract available

SIVINA M, Xiao L, Kim E, Vaca A, et al
CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia.
Leukemia. 2020 Oct 21. pii: 10.1038/s41375-020-01063.
PubMed Abstract available

BARNEA SLONIM L, Gao J, Burkart M, Odetola OE, et al
Therapy-related B-cell acute lymphoblastic leukemia in adults has unique genetic profile with frequent loss of TP53 and inferior outcome.
Leukemia. 2020 Oct 21. pii: 10.1038/s41375-020-01061.
PubMed

BRECCIA M, Piciocchi A, De Stefano V, Finazzi G, et al
COVID-19 in Philadelphia-negative myeloproliferative disorders: a GIMEMA survey.
Leukemia. 2020;34:2813-2814.
PubMed

LAI P, Chen X, Qin L, Jiang Z, et al
The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection.
Leukemia. 2020;34:2790-2793.
PubMed

WANG Y, Liu Y, Tan X, Pan B, et al
Safety and efficacy of chimeric antigen receptor (CAR)-T-cell therapy in persons with advanced B-cell cancers and hepatitis B virus-infection.
Leukemia. 2020;34:2704-2707.
PubMed Abstract available

MYBURGH R, Kiefer JD, Russkamp NF, Magnani CF, et al
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells.
Leukemia. 2020;34:2688-2703.
PubMed Abstract available

September 2020

ECTOR GICG, Visser O, Westerweel PE, Janssen JJWM, et al
Correction: Primary therapy and relative survival among elderly patients with chronic myeloid leukemia: a population-based study in the Netherlands, 1989-2017.
Leukemia. 2020 Sep 28. pii: 10.1038/s41375-020-01040.
PubMed Abstract available

KATTIH B, Shirvani A, Klement P, Garrido AM, et al
IDH1/2 mutations in acute myeloid leukemia patients and risk of coronary artery disease and cardiac dysfunction-a retrospective propensity score analysis.
Leukemia. 2020 Sep 18. pii: 10.1038/s41375-020-01043.
PubMed Abstract available

LETESTU R, Dahmani A, Boubaya M, Baseggio L, et al
Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia.
Leukemia. 2020 Sep 15. pii: 10.1038/s41375-020-01009.
PubMed Abstract available

JUNCO JJ, Chen T, Rashid R, Terrell M, et al
An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance.
Leukemia. 2020 Sep 11. pii: 10.1038/s41375-020-01036.
PubMed

REDA G, Noto A, Cassin R, Zamprogna G, et al
Reply to "CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report" Analysis of six hematological centers in Lombardy : On behalf of CLL commission of Lombardy Hematology Network (REL).
Leukemia. 2020;34:2531-2532.
PubMed

ECTOR GICG, Huijskens EGW, Blijlevens NMA, Westerweel PE, et al
Prevalence of COVID-19 diagnosis in Dutch CML patients during the 2020 SARS-CoV2 pandemic. A prospective cohort study.
Leukemia. 2020;34:2533-2535.
PubMed

QIU Y, Huang S
CTCF-mediated genome organization and leukemogenesis.
Leukemia. 2020;34:2295-2304.
PubMed Abstract available

KAYSER S, Rahme R, Martinez-Cuadron D, Ghiaur G, et al
Outcome of older (>/=70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study.
Leukemia. 2020;34:2333-2341.
PubMed Abstract available

August 2020

ROEKER LE, Knorr DA, Pessin MS, Ramanathan LV, et al
Anti-SARS-CoV-2 antibody response in patients with chronic lymphocytic leukemia.
Leukemia. 2020 Aug 27. pii: 10.1038/s41375-020-01030.
PubMed

VON WENSERSKI L, Schultheiss C, Bolz S, Schliffke S, et al
SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2.
Leukemia. 2020 Aug 21. pii: 10.1038/s41375-020-01025.
PubMed Abstract available

ADNAN AWAD S, Dufva O, Ianevski A, Ghimire B, et al
RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses.
Leukemia. 2020 Aug 11. pii: 10.1038/s41375-020-01011.
PubMed Abstract available

MIMS AS, Kohlschmidt J, Eisfeld AK, Mromicronzek K, et al
Comparison of clinical and molecular characteristics of patients with acute myeloid leukemia and either TP73 or TP53 mutations.
Leukemia. 2020 Aug 5. pii: 10.1038/s41375-020-1007.
PubMed

FURSTENAU M, Langerbeins P, De Silva N, Fink AM, et al
COVID-19 among fit patients with CLL treated with venetoclax-based combinations.
Leukemia. 2020;34:2225-2229.
PubMed

MACHOVA POLAKOVA K, Zizkova H, Zuna J, Motlova E, et al
Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission.
Leukemia. 2020;34:2113-2124.
PubMed Abstract available

HEHLMANN R, Voskanyan A, Lauseker M, Pfirrmann M, et al
High-risk additional chromosomal abnormalities at low blast counts herald death by CML.
Leukemia. 2020;34:2074-2086.
PubMed Abstract available

KAISER A, Schmidt M, Huber O, Frietsch JJ, et al
SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders.
Leukemia. 2020;34:2206-2216.
PubMed Abstract available

July 2020

AUMANN WK, Heath JL, Conway AE, Sze SK, et al
Fusion of the CRM1 nuclear export receptor to AF10 causes leukemia and transcriptional activation of HOXA genes.
Leukemia. 2020 Jul 30. pii: 10.1038/s41375-020-0998.
PubMed

DEL GALY AS, Marouf A, Raffoux E, Robin M, et al
Letter to the Editor: Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality.
Leukemia. 2020 Jul 30. pii: 10.1038/s41375-020-1004.
PubMed

TOSELLO V, Bongiovanni D, Liu J, Pan Q, et al
Cross-talk between GLI transcription factors and FOXC1 promotes T-cell acute lymphoblastic leukemia dissemination.
Leukemia. 2020 Jul 30. pii: 10.1038/s41375-020-0999.
PubMed Abstract available

GASSNER FJ, Zaborsky N, Buchumenski I, Levanon EY, et al
RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia.
Leukemia. 2020 Jul 30. pii: 10.1038/s41375-020-0995.
PubMed Abstract available

YUN S, Geyer SM, Komrokji RS, Al Ali NH, et al
Prognostic significance of serial molecular annotation in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML).
Leukemia. 2020 Jul 29. pii: 10.1038/s41375-020-0997.
PubMed Abstract available

ANDERSEN MA, Moser CE, Lundgren J, Niemann CU, et al
Correction: Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study.
Leukemia. 2020 Jul 27. pii: 10.1038/s41375-020-0992.
PubMed Abstract available

FANG C, Rao S, Crispino JD, Ntziachristos P, et al
Determinants and role of chromatin organization in acute leukemia.
Leukemia. 2020 Jul 20. pii: 10.1038/s41375-020-0981.
PubMed Abstract available

PARTING O, Langer S, Kuepper MK, Wessling C, et al
Therapeutic inhibition of FcgammaRIIb signaling targets leukemic stem cells in chronic myeloid leukemia.
Leukemia. 2020 Jul 20. pii: 10.1038/s41375-020-0977.
PubMed Abstract available

ANDERSEN MA, Rostgaard K, Niemann CU, Hjalgrim H, et al
Antimicrobial use before chronic lymphocytic leukemia: a retrospective cohort study.
Leukemia. 2020 Jul 20. pii: 10.1038/s41375-020-0980.
PubMed Abstract available

JESTIN M, Tarfi S, Duchmann M, Badaoui B, et al
Prognostic value of monocyte subset distribution in chronic myelomonocytic leukemia: results of a multicenter study.
Leukemia. 2020 Jul 20. pii: 10.1038/s41375-020-0955.
PubMed

MALANI D, Yadav B, Kumar A, Potdar S, et al
KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia.
Leukemia. 2020 Jul 17. pii: 10.1038/s41375-020-0978.
PubMed

GRUBER E, Franich RL, Shortt J, Johnstone RW, et al
Distinct and overlapping mechanisms of resistance to azacytidine and guadecitabine in acute myeloid leukemia.
Leukemia. 2020 Jul 13. pii: 10.1038/s41375-020-0973.
PubMed

BROWN JR, Zelenetz A, Furman R, Lamanna N, et al
Risk factors for grade 3/4 transaminase elevation in patients with chronic lymphocytic leukemia treated with idelalisib.
Leukemia. 2020 Jul 12. pii: 10.1038/s41375-020-0974.
PubMed

TAMBE M, Karjalainen E, Vaha-Koskela M, Bulanova D, et al
Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition.
Leukemia. 2020 Jul 10. pii: 10.1038/s41375-020-0972.
PubMed Abstract available

SCARFO L, Chatzikonstantinou T, Rigolin GM, Quaresmini G, et al
COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.
Leukemia. 2020 Jul 9. pii: 10.1038/s41375-020-0959.
PubMed Abstract available

ABECASIS M, Cross NCP, Brito M, Ferreira I, et al
Is cancer latency an outdated concept? Lessons from chronic myeloid leukemia.
Leukemia. 2020 Jul 6. pii: 10.1038/s41375-020-0957.
PubMed Abstract available

OSTERGAARD A, Bohnstedt C, Grell K, Degn M, et al
Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy.
Leukemia. 2020 Jul 4. pii: 10.1038/s41375-020-0946.
PubMed

BAUMANN T, Delgado J, Montserrat E
CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report.
Leukemia. 2020;34:1954-1956.
PubMed

LI W, Wang D, Guo J, Yuan G, et al
COVID-19 in persons with chronic myeloid leukaemia.
Leukemia. 2020;34:1799-1804.
PubMed Abstract available

REISSER T, Halbgebauer D, Scheurer J, Wolf L, et al
In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease.
Leukemia. 2020;34:1943-1948.
PubMed

OSSENKOPPELE GJ, Breems DA, Stuessi G, van Norden Y, et al
Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS.
Leukemia. 2020;34:1751-1759.
PubMed Abstract available

BLAKEMORE SJ, Clifford R, Parker H, Antoniou P, et al
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial.
Leukemia. 2020;34:1760-1774.
PubMed Abstract available

KIM R, Boissel N, Touzart A, Leguay T, et al
Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation.
Leukemia. 2020;34:1730-1740.
PubMed Abstract available

GERNER RR, Macheiner S, Reider S, Siegmund K, et al
Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity.
Leukemia. 2020;34:1885-1897.
PubMed Abstract available

HORNE GA, Stobo J, Kelly C, Mukhopadhyay A, et al
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease.
Leukemia. 2020;34:1775-1786.
PubMed Abstract available

June 2020

GARCIA EG, Veloso A, Oliveira ML, Allen JR, et al
PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis.
Leukemia. 2020 Jun 30. pii: 10.1038/s41375-020-0937.
PubMed Abstract available

PFIRRMANN M, Clark RE, Prejzner W, Lauseker M, et al
The EUTOS long-term survival (ELTS) score is superior to the Sokal score for predicting survival in chronic myeloid leukemia.
Leukemia. 2020 Jun 29. pii: 10.1038/s41375-020-0931.
PubMed Abstract available

JENSEN P, Carlet M, Schlenk RF, Weber A, et al
Requirement for LIM kinases in acute myeloid leukemia.
Leukemia. 2020 Jun 26. pii: 10.1038/s41375-020-0943.
PubMed Abstract available

LOONTIENS S, Vanhauwaert S, Depestel L, Dewyn G, et al
A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models.
Leukemia. 2020 Jun 26. pii: 10.1038/s41375-020-0938.
PubMed

CERRANO M, Duchmann M, Kim R, Vasseur L, et al
Clonal dominance is an adverse prognostic factor in acute myeloid leukemia treated with intensive chemotherapy.
Leukemia. 2020 Jun 24. pii: 10.1038/s41375-020-0932.
PubMed Abstract available

KLOOS A, Mintzas K, Winckler L, Gabdoulline R, et al
Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.
Leukemia. 2020 Jun 24. pii: 10.1038/s41375-020-0929.
PubMed Abstract available

HOCHHAUS A, Gambacorti-Passerini C, Abboud C, Gjertsen BT, et al
Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study.
Leukemia. 2020 Jun 22. pii: 10.1038/s41375-020-0915.
PubMed Abstract available

MOLICA S, Giannarelli D
Prognostic models for chronic lymphocytic leukemia (CLL): a systematic review and meta-analysis.
Leukemia. 2020 Jun 21. pii: 10.1038/s41375-020-0924.
PubMed

FERRARA F, Zappasodi P, Roncoroni E, Borlenghi E, et al
Impact of Covid-19 on the treatment of acute myeloid leukemia.
Leukemia. 2020 Jun 19. pii: 10.1038/s41375-020-0925.
PubMed

DAVI F, Langerak AW, de Septenville AL, Kolijn PM, et al
Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing.
Leukemia. 2020 Jun 19. pii: 10.1038/s41375-020-0923.
PubMed Abstract available

ALFAYEZ M, Issa GC, Patel KP, Wang F, et al
The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.
Leukemia. 2020 Jun 19. pii: 10.1038/s41375-020-0920.
PubMed Abstract available

BRECCIA M, Abruzzese E, Bocchia M, Bonifacio M, et al
Chronic myeloid leukemia management at the time of the COVID-19 pandemic in Italy. A campus CML survey.
Leukemia. 2020 Jun 18. pii: 10.1038/s41375-020-0904.
PubMed

HAUER J, Fischer U, Auer F, Borkhardt A, et al
Regional BCG vaccination policy in former East- and West Germany may impact on both severity of SARS-CoV-2 and incidence of childhood leukemia.
Leukemia. 2020 Jun 18. pii: 10.1038/s41375-020-0871.
PubMed

MARCAIS A, Lhermitte L, Artesi M, Laurent C, et al
Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype.
Leukemia. 2020 Jun 17. pii: 10.1038/s41375-020-0900.
PubMed Abstract available

MAURO FR, Giannarelli D, Galluzzo CM, Vitale C, et al
Response to the conjugate pneumococcal vaccine (PCV13) in patients with chronic lymphocytic leukemia (CLL).
Leukemia. 2020 Jun 17. pii: 10.1038/s41375-020-0884.
PubMed Abstract available

ISSA GC, Kantarjian HM, Xiao L, Ning J, et al
Phase II trial of CPX-351 in patients with acute myeloid leukemia at high risk for induction mortality.
Leukemia. 2020 Jun 16. pii: 10.1038/s41375-020-0916.
PubMed Abstract available

POPOV A, Buldini B, De Lorenzo P, Disaro S, et al
Prognostic value of minimal residual disease measured by flow-cytometry in two cohorts of infants with acute lymphoblastic leukemia treated according to either MLL-Baby or Interfant protocols.
Leukemia. 2020 Jun 12. pii: 10.1038/s41375-020-0912.
PubMed

WONG RL, Ketcham M, Irwin T, Akilesh S, et al
Donor-derived acute promyelocytic leukemia presenting as myeloid sarcoma in a transplanted kidney.
Leukemia. 2020 Jun 10. pii: 10.1038/s41375-020-0903.
PubMed

NORSWORTHY KJ, Avagyan A, Bird ST, Li Y, et al
Second cancers in adults with acute promyelocytic leukemia treated with or without arsenic trioxide: a SEER-medicare analysis.
Leukemia. 2020 Jun 9. pii: 10.1038/s41375-020-0905.
PubMed

ECTOR GICG, Visser O, Westerweel PE, Janssen JJWM, et al
Primary therapy and relative survival among elderly patients with chronic myeloid leukemia: a population-based study in the Netherlands, 1989-2017.
Leukemia. 2020 Jun 8. pii: 10.1038/s41375-020-0902.
PubMed

YAN F, Wong NC, Powell DR, Curtis DJ, et al
A 9-gene score for risk stratification in B-cell acute lymphoblastic leukemia.
Leukemia. 2020 Jun 2. pii: 10.1038/s41375-020-0888.
PubMed

WANDER P, Cheung LC, Pinhanos SS, Jones L, et al
Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia.
Leukemia. 2020 Jun 2. pii: 10.1038/s41375-020-0895.
PubMed

MIMMI S, Maisano D, Nistico N, Vecchio E, et al
Detection of chronic lymphocytic leukemia subpopulations in peripheral blood by phage ligands of tumor immunoglobulin B cell receptors.
Leukemia. 2020 Jun 1. pii: 10.1038/s41375-020-0885.
PubMed

QUIJADA-ALAMO M, Hernandez-Sanchez M, Alonso-Perez V, Rodriguez-Vicente AE, et al
CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition.
Leukemia. 2020;34:1599-1612.
PubMed Abstract available

MORSINK LM, Othus M, Bezerra ED, Wood BL, et al
Impact of pretransplant measurable residual disease on the outcome of allogeneic hematopoietic cell transplantation in adult monosomal karyotype AML.
Leukemia. 2020;34:1577-1587.
PubMed Abstract available

ZEIDNER JF, Knaus HA, Zeidan AM, Blackford AL, et al
Immunomodulation with pomalidomide at early lymphocyte recovery after induction chemotherapy in newly diagnosed AML and high-risk MDS.
Leukemia. 2020;34:1563-1576.
PubMed Abstract available

CAYE A, Rouault-Pierre K, Strullu M, Lainey E, et al
Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment.
Leukemia. 2020;34:1658-1668.
PubMed Abstract available

May 2020

ZINNGREBE J, Debatin KM, Fischer-Posovszky P
Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?
Leukemia. 2020 May 30. pii: 10.1038/s41375-020-0886.
PubMed Abstract available

EISFELD AK, Kohlschmidt J, Mims A, Nicolet D, et al
Additional gene mutations may refine the 2017 European LeukemiaNet classification in adult patients with de novo acute myeloid leukemia aged <60 years.
Leukemia. 2020 May 27. pii: 10.1038/s41375-020-0872.
PubMed Abstract available

MIDIC D, Rinke J, Perner F, Muller V, et al
Prevalence and dynamics of clonal hematopoiesis caused by leukemia-associated mutations in elderly individuals without hematologic disorders.
Leukemia. 2020 May 26. pii: 10.1038/s41375-020-0869.
PubMed Abstract available

SHARF G, Marin C, Bradley JA, Pemberton-Whiteley Z, et al
Treatment-free remission in chronic myeloid leukemia: the patient perspective and areas of unmet needs.
Leukemia. 2020 May 26. pii: 10.1038/s41375-020-0867.
PubMed Abstract available

ROESSNER PM, Seiffert M
T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?
Leukemia. 2020 May 26. pii: 10.1038/s41375-020-0873.
PubMed Abstract available

CARTEL M, Mouchel PL, Gotanegre M, David L, et al
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy.
Leukemia. 2020 May 23. pii: 10.1038/s41375-020-0878.
PubMed Abstract available

KUMAR R, Pereira RS, Zanetti C, Minciacchi VR, et al
Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia.
Leukemia. 2020 May 21. pii: 10.1038/s41375-020-0866.
PubMed Abstract available

LAURENT AP, Kotecha RS, Malinge S
Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome.
Leukemia. 2020 May 20. pii: 10.1038/s41375-020-0854.
PubMed Abstract available

BAMEZAI S, Demir D, Pulikkottil AJ, Ciccarone F, et al
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.
Leukemia. 2020 May 15. pii: 10.1038/s41375-020-0864.
PubMed Abstract available

LORENTINO F, Labopin M, Ciceri F, Vago L, et al
Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia.
Leukemia. 2020 May 14. pii: 10.1038/s41375-020-0863.
PubMed Abstract available

LUKAS M, Velten B, Sellner L, Tomska K, et al
Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies.
Leukemia. 2020 May 13. pii: 10.1038/s41375-020-0846.
PubMed Abstract available

YOUNG KH
Good prognosis or poor prognosis, dose-intensive or less intensive: who decides for adults with T-lymphoblastic lymphoma/leukemia.
Leukemia. 2020 May 12. pii: 10.1038/s41375-020-0861.
PubMed

KARLSSON C, Akula MK, Staffas A, Cisowski J, et al
Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
Leukemia. 2020 May 12. pii: 10.1038/s41375-020-0859.
PubMed

PARIKH SA, Gale RP, Kay NE
Chronic lymphocytic leukemia in 2020: a surfeit of riches?
Leukemia. 2020 May 11. pii: 10.1038/s41375-020-0852.
PubMed

NAGLER A, Dholaria B, Labopin M, Savani BN, et al
Bone marrow versus mobilized peripheral blood stem cell graft in T-cell-replete haploidentical transplantation in acute lymphoblastic leukemia.
Leukemia. 2020 May 11. pii: 10.1038/s41375-020-0850.
PubMed Abstract available

GARCIA-CANAVERAS JC, Lancho O, Ducker GS, Ghergurovich JM, et al
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia.
Leukemia. 2020 May 7. pii: 10.1038/s41375-020-0845.
PubMed Abstract available

HOCHHAUS A, Breccia M, Saglio G, Garcia-Gutierrez V, et al
Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors.
Leukemia. 2020 May 4. pii: 10.1038/s41375-020-0842.
PubMed Abstract available

JOSHI SK, Keck JM, Eide CA, Bottomly D, et al
ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia.
Leukemia. 2020 May 4. pii: 10.1038/s41375-020-0844.
PubMed

BAMOPOULOS SA, Batcha AMN, Jurinovic V, Rothenberg-Thurley M, et al
Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.
Leukemia. 2020 May 1. pii: 10.1038/s41375-020-0839.
PubMed Abstract available

REICH D, Kresinsky A, Muller JP, Bauer R, et al
SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells.
Leukemia. 2020;34:1444-1449.
PubMed

DUPLOYEZ N, Goursaud L, Fenwarth L, Bories C, et al
Familial myeloid malignancies with germline TET2 mutation.
Leukemia. 2020;34:1450-1453.
PubMed

DEB G, Wingelhofer B, Amaral FMR, Maiques-Diaz A, et al
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia.
Leukemia. 2020;34:1266-1277.
PubMed Abstract available

RODRIGUEZ S, Abundis C, Boccalatte F, Mehrotra P, et al
Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.
Leukemia. 2020;34:1241-1252.
PubMed Abstract available

SCHNEIDER E, Pochert N, Ruess C, MacPhee L, et al
MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells.
Leukemia. 2020;34:1253-1265.
PubMed Abstract available

April 2020

TOMLINSON CG, Sasa G, Aubert G, Martin-Giacalone B, et al
Clinical and functional characterization of telomerase variants in patients with pediatric acute myeloid leukemia/myelodysplastic syndrome.
Leukemia. 2020 Apr 21. pii: 10.1038/s41375-020-0835.
PubMed

DHAKAL B, Patel S, Girnius S, Bachegowda L, et al
Hematopoietic cell transplantation utilization and outcomes for primary plasma cell leukemia in the current era.
Leukemia. 2020 Apr 20. pii: 10.1038/s41375-020-0830.
PubMed Abstract available

WAKAMATSU M, Okuno Y, Murakami N, Miwata S, et al
Detection of subclonal SETBP1 and JAK3 mutations in juvenile myelomonocytic leukemia using droplet digital PCR.
Leukemia. 2020 Apr 20. pii: 10.1038/s41375-020-0817.
PubMed

ELSAYED AH, Rafiee R, Cao X, Raimondi S, et al
Correction: A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.
Leukemia. 2020 Apr 16. pii: 10.1038/s41375-020-0822.
PubMed Abstract available

GENTILE M, Morabito F, Del Poeta G, Mauro FR, et al
Survival risk score for real-life relapsed/refractory chronic lymphocytic leukemia patients receiving ibrutinib. A campus CLL study.
Leukemia. 2020 Apr 14. pii: 10.1038/s41375-020-0833.
PubMed

THASTRUP M, Marquart HV, Levinsen M, Grell K, et al
Correction: Flow cytometric detection of leukemic blasts in cerebrospinal fluid predicts risk of relapse in childhood acute lymphoblastic leukemia: a Nordic Society of Pediatric Hematology and Oncology study.
Leukemia. 2020 Apr 8. pii: 10.1038/s41375-020-0821.
PubMed Abstract available

CORTES JE, Jiang Q, Wang J, Weng J, et al
Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study.
Leukemia. 2020 Apr 7. pii: 10.1038/s41375-020-0805.
PubMed Abstract available

GODFREY L, Crump NT, O'Byrne S, Lau IJ, et al
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Leukemia. 2020 Apr 2. pii: 10.1038/s41375-020-0808.
PubMed Abstract available

RUZICKA M, Koenig LM, Formisano S, Boehmer DFR, et al
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
Leukemia. 2020;34:1017-1026.
PubMed Abstract available

WINICK N, Martin PL, Devidas M, Shuster J, et al
Randomized assessment of delayed intensification and two methods for parenteral methotrexate delivery in childhood B-ALL: Children's Oncology Group Studies P9904 and P9905.
Leukemia. 2020;34:1006-1016.
PubMed Abstract available

HOECHSTETTER MA, Busch R, Eichhorst B, Buhler A, et al
Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group.
Leukemia. 2020;34:1038-1051.
PubMed Abstract available

FEDER K, Edmaier-Schroger K, Rawat VPS, Kirsten N, et al
Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.
Leukemia. 2020;34:1027-1037.
PubMed Abstract available

REN Z, Shrestha M, Sakamoto T, Melkman T, et al
Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML.
Leukemia. 2020;34:1172-1176.
PubMed

NAGLER A, Dholaria B, Labopin M, Socie G, et al
The impact of anti-thymocyte globulin on the outcomes of Patients with AML with or without measurable residual disease at the time of allogeneic hematopoietic cell transplantation.
Leukemia. 2020;34:1144-1153.
PubMed Abstract available

KHAN HM, Gardner KM, Shaw C, Halpern AB, et al
Need for routine examination of left ventricular ejection fraction in patients with AML.
Leukemia. 2020;34:1169-1171.
PubMed

ASNANI M, Hayer KE, Naqvi AS, Zheng S, et al
Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19.
Leukemia. 2020;34:1202-1207.
PubMed

March 2020

HEROLD T, Rothenberg-Thurley M, Grunwald VV, Janke H, et al
Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia.
Leukemia. 2020 Mar 30. pii: 10.1038/s41375-020-0806.
PubMed Abstract available

MONTALBAN-BRAVO G, Class CA, Ganan-Gomez I, Kanagal-Shamanna R, et al
Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes.
Leukemia. 2020;34:872-881.
PubMed Abstract available

TATSUMI G, Kawahara M, Yamamoto R, Hishizawa M, et al
LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia.
Leukemia. 2020;34:746-758.
PubMed Abstract available

BURGER JA, Barr PM, Robak T, Owen C, et al
Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study.
Leukemia. 2020;34:787-798.
PubMed Abstract available

HERBRUEGGEN H, Mueller S, Rohde J, Arias Padilla L, et al
Treatment and outcome of IG-MYC(+) neoplasms with precursor B-cell phenotype in childhood and adolescence.
Leukemia. 2020;34:942-946.
PubMed

February 2020

TIAN XP, Xie D, Huang WJ, Ma SY, et al
A gene-expression-based signature predicts survival in adults with T-cell lymphoblastic lymphoma: a multicenter study.
Leukemia. 2020 Feb 20. pii: 10.1038/s41375-020-0757.
PubMed Abstract available

RADIVOYEVITCH T, Weaver D, Hobbs B, Maciejewski JP, et al
Do persons with chronic myeloid leukaemia have normal or near normal survival?
Leukemia. 2020;34:333-335.
PubMed

LANCE A, Druhan LJ, Vestal CG, Steuerwald NM, et al
Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations.
Leukemia. 2020;34:369-379.
PubMed Abstract available

CHATURVEDI A, Goparaju R, Gupta C, Weder J, et al
In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia. 2020;34:416-426.
PubMed Abstract available

CHAO AK, Meyer JA, Lee AG, Hecht A, et al
Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing.
Leukemia. 2020;34:662-666.
PubMed

INNES AJ, Woolley P, Szydlo RM, Lozano S, et al
Complete remission with incomplete count recovery (CRi) prior to allogeneic HCT for acute myeloid leukaemia is associated with a high non-relapse mortality.
Leukemia. 2020;34:667-670.
PubMed

SKANLAND SS, Cremaschi A, Bendiksen H, Hermansen JU, et al
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL.
Leukemia. 2020;34:478-487.
PubMed Abstract available

January 2020

RASHIDI A, Kaiser T, Graiziger C, Holtan SG, et al
Specific gut microbiota changes heralding bloodstream infection and neutropenic fever during intensive chemotherapy.
Leukemia. 2020;34:312-316.
PubMed

KANDA J, Hayashi H, Ruggeri A, Kimura F, et al
Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study.
Leukemia. 2020;34:128-137.
PubMed Abstract available

CUTLER JA, Udainiya S, Madugundu AK, Renuse S, et al
Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling.
Leukemia. 2020;34:301-305.
PubMed

GILLEECE MH, Labopin M, Savani BN, Yakoub-Agha I, et al
Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT.
Leukemia. 2020;34:87-99.
PubMed Abstract available

BISAILLON R, Moison C, Thiollier C, Krosl J, et al
Genetic characterization of ABT-199 sensitivity in human AML.
Leukemia. 2020;34:63-74.
PubMed Abstract available

YOSIFOV DY, Idler I, Bhattacharya N, Reichenzeller M, et al
Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.
Leukemia. 2020;34:115-127.
PubMed Abstract available

October 2019

YOUNG KH
Hematopoietic stem cell transplantation for adults with T-cell lymphoblastic lymphoma: can we successfully step into the era of precision medicine?
Leukemia. 2019 Oct 22. pii: 10.1038/s41375-019-0608.
PubMed

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