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Leukemia

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Articles published in Leukemia
Retrieve available abstracts of 344 articles:
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April 2019

POLLYEA DA, Tallman MS, de Botton S, Kantarjian HM, et al
Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia.
Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0472.
PubMed Text format Abstract available

DONG Y, Zhao X, Feng X, Zhou Y, et al
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints.
Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0456.
PubMed Text format Abstract available

KLEIN K, Witalisz-Siepracka A, Maurer B, Prinz D, et al
STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia.
Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0471.
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LIN M, Nebral K, Gertzen CGW, Ganmore I, et al
JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility.
Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0459.
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HYRENIUS-WITTSTEN A, Pilheden M, Falques-Costa A, Eriksson M, et al
FLT3(N676K) drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis.
Leukemia. 2019 Apr 5. pii: 10.1038/s41375-019-0465.
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EISENWORT G, Sadovnik I, Schwaab J, Jawhar M, et al
Identification of a leukemia-initiating stem cell in human mast cell leukemia.
Leukemia. 2019 Apr 5. pii: 10.1038/s41375-019-0460.
PubMed Text format Abstract available

CHEN YL, Tang C, Zhang MY, Huang WL, et al
Blocking ATM-dependent NF-kappaB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia.
Leukemia. 2019 Apr 2. pii: 10.1038/s41375-019-0458.
PubMed Text format Abstract available

March 2019

EL-JAWAHRI A, Abel GA, Traeger L, Waldman L, et al
Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy.
Leukemia. 2019 Mar 28. pii: 10.1038/s41375-019-0449.
PubMed Text format Abstract available

JEBARAJ BMC, Tausch E, Landau DA, Bahlo J, et al
Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia.
Leukemia. 2019 Mar 25. pii: 10.1038/s41375-019-0446.
PubMed Text format Abstract available

VISHWAKARMA BA, Gudmundsson KO, Oakley K, Han Y, et al
Insertional mutagenesis identifies cooperation between Setbp1 and Mllt3 in inducing myeloid leukemia development.
Leukemia. 2019 Mar 20. pii: 10.1038/s41375-019-0445.
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LUCAS N, Duchmann M, Rameau P, Noel F, et al
Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia.
Leukemia. 2019 Mar 20. pii: 10.1038/s41375-019-0447.
PubMed Text format Abstract available

RADPOUR R, Riether C, Simillion C, Hopner S, et al
CD8(+) T cells expand stem and progenitor cells in favorable but not adverse risk acute myeloid leukemia.
Leukemia. 2019 Mar 15. pii: 10.1038/s41375-019-0441.
PubMed Text format Abstract available

JANSSEN L, Frambach SJCM, Allard NAE, Hopman MTE, et al
Skeletal muscle toxicity associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.
Leukemia. 2019 Mar 14. pii: 10.1038/s41375-019-0443.
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VENDRAMINI E, Bomben R, Pozzo F, Benedetti D, et al
KRAS, NRAS, and BRAF mutations are highly enriched in trisomy 12 chronic lymphocytic leukemia and are associated with shorter treatment-free survival.
Leukemia. 2019 Mar 14. pii: 10.1038/s41375-019-0444.
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PFEIFER H, Cazzaniga G, van der Velden VHJ, Cayuela JM, et al
Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1.
Leukemia. 2019 Mar 11. pii: 10.1038/s41375-019-0413.
PubMed Text format Abstract available

BILL M, Papaioannou D, Karunasiri M, Kohlschmidt J, et al
Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells.
Leukemia. 2019 Mar 11. pii: 10.1038/s41375-019-0429.
PubMed Text format Abstract available

AKKAPEDDI P, Fragoso R, Hixon JA, Ramalho AS, et al
A fully human anti-IL-7Ralpha antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
Leukemia. 2019 Mar 8. pii: 10.1038/s41375-019-0434.
PubMed Text format Abstract available

HE X, Xiao X, Li Q, Jiang Y, et al
Anti-CD19 CAR-T as a feasible and safe treatment against central nervous system leukemia after intrathecal chemotherapy in adults with relapsed or refractory B-ALL.
Leukemia. 2019 Mar 7. pii: 10.1038/s41375-019-0437.
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CANAANI J, Labopin M, Itala-Remes M, Blaise D, et al
Prognostic significance of recurring chromosomal abnormalities in transplanted patients with acute myeloid leukemia.
Leukemia. 2019 Mar 7. pii: 10.1038/s41375-019-0439.
PubMed Text format Abstract available

BHOJWANI D, Sposto R, Shah NN, Rodriguez V, et al
Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia.
Leukemia. 2019 Mar 7. pii: 10.1038/s41375-019-0426.
PubMed Text format Abstract available

BASTIAN L, Schroeder MP, Eckert C, Schlee C, et al
PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.
Leukemia. 2019 Mar 6. pii: 10.1038/s41375-019-0430.
PubMed Text format Abstract available

February 2019

STEINHERZ PG, Seibel NL, Sather H, Ji L, et al
Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children's Oncology Group.
Leukemia. 2019 Feb 28. pii: 10.1038/s41375-019-0422.
PubMed Text format Abstract available

BUENO C, Velasco-Hernandez T, Gutierrez-Aguera F, Zanetti SR, et al
CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity.
Leukemia. 2019 Feb 18. pii: 10.1038/s41375-019-0418.
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MCNEER NA, Philip J, Geiger H, Ries RE, et al
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia.
Leukemia. 2019 Feb 13. pii: 10.1038/s41375-019-0402.
PubMed Text format Abstract available

MROZEK K, Eisfeld AK, Kohlschmidt J, Carroll AJ, et al
Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically.
Leukemia. 2019 Feb 8. pii: 10.1038/s41375-019-0390.
PubMed Text format Abstract available

BENARD B, Gentles AJ, Kohnke T, Majeti R, et al
Data mining for mutation-specific targets in acute myeloid leukemia.
Leukemia. 2019 Feb 6. pii: 10.1038/s41375-019-0387.
PubMed Text format Abstract available

GUENOT C, Lacombe F, Allou K, Dumezy F, et al
Peripheral blood minimal/measurable residual disease assessed in flow cytometry in acute myeloblastic leukemia.
Leukemia. 2019 Feb 5. pii: 10.1038/s41375-019-0393.
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January 2019

MASCHMEYER G, De Greef J, Mellinghoff SC, Nosari A, et al
Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL).
Leukemia. 2019 Jan 30. pii: 10.1038/s41375-019-0388.
PubMed Text format Abstract available

CHEN R, Zhu M, Chaudhari RR, Robles O, et al
Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia.
Leukemia. 2019 Jan 30. pii: 10.1038/s41375-018-0364.
PubMed Text format Abstract available

SHI Y, Wang G, Muhowski EM, McCaw L, et al
Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells.
Leukemia. 2019 Jan 29. pii: 10.1038/s41375-019-0381.
PubMed Text format Abstract available

SCHMIDT L, Heyes E, Scheiblecker L, Eder T, et al
CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex.
Leukemia. 2019 Jan 24. pii: 10.1038/s41375-019-0382.
PubMed Text format Abstract available

KROMBHOLZ CF, Gallego-Villar L, Sahoo SS, Panda PK, et al
Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.
Leukemia. 2019 Jan 24. pii: 10.1038/s41375-018-0343.
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MOYSIADIS T, Baliakas P, Rossi D, Catherwood M, et al
Different time-dependent changes of risk for evolution in chronic lymphocytic leukemia with mutated or unmutated antigen b-receptors.
Leukemia. 2019 Jan 24. pii: 10.1038/s41375-018-0322.
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KOLLMANN S, Grundschober E, Maurer B, Warsch W, et al
Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.
Leukemia. 2019 Jan 24. pii: 10.1038/s41375-018-0369.
PubMed Text format Abstract available

HOFFMANN H, Thiede C, Glauche I, Kramer M, et al
The prognostic potential of monitoring disease dynamics in NPM1-positive acute myeloid leukemia.
Leukemia. 2019 Jan 23. pii: 10.1038/s41375-018-0371.
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NABINGER SC, Chen S, Gao R, Yao C, et al
Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.
Leukemia. 2019 Jan 23. pii: 10.1038/s41375-019-0377.
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BACCARANI M, Castagnetti F, Gugliotta G, Rosti G, et al
The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview.
Leukemia. 2019 Jan 23. pii: 10.1038/s41375-018-0341.
PubMed Text format Abstract available

ESTEY E, Othus M, Gale RP
New study-designs to address the clinical complexity of acute myeloid leukemia.
Leukemia. 2019 Jan 22. pii: 10.1038/s41375-018-0363.
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FIORCARI S, Benatti S, Zucchetto A, Zucchini P, et al
Overexpression of CD49d in trisomy 12 chronic lymphocytic leukemia patients is mediated by IRF4 through induction of IKAROS.
Leukemia. 2019 Jan 18. pii: 10.1038/s41375-018-0296.
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ALFONSO V, Iaccarino L, Ottone T, Cicconi L, et al
Early and sensitive detection of PML-A216V mutation by droplet digital PCR in ATO-resistant acute promyelocytic leukemia.
Leukemia. 2019 Jan 16. pii: 10.1038/s41375-018-0298.
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LOPEZ-MILLAN B, Sanchez-Martinez D, Roca-Ho H, Gutierrez-Aguera F, et al
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.
Leukemia. 2019 Jan 11. pii: 10.1038/s41375-018-0353.
PubMed Text format Abstract available

JAWHAR M, Dohner K, Kreil S, Schwaab J, et al
KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis.
Leukemia. 2019 Jan 11. pii: 10.1038/s41375-018-0346.
PubMed Text format Abstract available

REDA G, Cassin R, Gentile M, Mauro FR, et al
IgA hypogammaglobulinemia predicts outcome in chronic lymphocytic leukemia.
Leukemia. 2019 Jan 11. pii: 10.1038/s41375-018-0344.
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OZTURK S, Roessner PM, Schulze-Edinghausen L, Yazdanparast H, et al
Rejection of adoptively transferred Emicro-TCL1 chronic lymphocytic leukemia cells in C57BL/6 substrains or knockout mouse lines.
Leukemia. 2019 Jan 11. pii: 10.1038/s41375-018-0332.
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HOANG VT, Verma D, Godavarthy PS, Llavona P, et al
The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.
Leukemia. 2019 Jan 11. pii: 10.1038/s41375-018-0358.
PubMed Text format Abstract available

GOUNARI M, Ntoufa S, Gerousi M, Vilia MG, et al
Dichotomous Toll-like receptor responses in chronic lymphocytic leukemia patients under ibrutinib treatment.
Leukemia. 2019 Jan 3. pii: 10.1038/s41375-018-0335.
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December 2018

ZHAO J, Liang JW, Xue HL, Shen SH, et al
The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia.
Leukemia. 2018 Dec 21. pii: 10.1038/s41375-018-0338.
PubMed Text format Abstract available

VELAZQUEZ-AVILA M, Balandran JC, Ramirez-Ramirez D, Velazquez-Avila M, et al
High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.
Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0333.
PubMed Text format Abstract available

SCHETELIG J, de Wreede LC, van Gelder M, Koster L, et al
Late treatment-related mortality versus competing causes of death after allogeneic transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia.
Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0302.
PubMed Text format Abstract available

EFFICACE F, Breccia M, Avvisati G, Cottone F, et al
Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia.
Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0325.
PubMed Text format Abstract available

BORGA C, Foster CA, Iyer S, Garcia SP, et al
Molecularly distinct models of zebrafish Myc-induced B cell leukemia.
Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0328.
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HANNA BS, Roessner PM, Scheffold A, Jebaraj BMC, et al
PI3Kdelta inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia.
Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0318.
PubMed Text format Abstract available

VON TRESCKOW J, Cramer P, Bahlo J, Robrecht S, et al
CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia.
Leukemia. 2018 Dec 19. pii: 10.1038/s41375-018-0313.
PubMed Text format Abstract available

KIVIOJA JL, Thanasopoulou A, Kumar A, Kontro M, et al
Dasatinib and navitoclax act synergistically to target NUP98-NSD1(+)/FLT3-ITD(+) acute myeloid leukemia.
Leukemia. 2018 Dec 19. pii: 10.1038/s41375-018-0327.
PubMed Text format Abstract available

REEDIJK AMJ, Klein K, Coebergh JWW, Kremer LC, et al
Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality.
Leukemia. 2018 Dec 19. pii: 10.1038/s41375-018-0314.
PubMed Text format Abstract available

HASAN MK, Rassenti L, Widhopf GF 2nd, Yu J, et al
Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells.
Leukemia. 2018 Dec 19. pii: 10.1038/s41375-018-0306.
PubMed Text format Abstract available

CORTES JE, Heidel FH, Hellmann A, Fiedler W, et al
Randomized comparison of low dose cytarabine with or without glasdegib in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome.
Leukemia. 2018 Dec 16. pii: 10.1038/s41375-018-0312.
PubMed Text format Abstract available

PARK JH, Woo YM, Youm EM, Hamad N, et al
HMGCLL1 is a predictive biomarker for deep molecular response to imatinib therapy in chronic myeloid leukemia.
Leukemia. 2018 Dec 16. pii: 10.1038/s41375-018-0321.
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TEN HACKEN E, Gounari M, Ghia P, Burger JA, et al
The importance of B cell receptor isotypes and stereotypes in chronic lymphocytic leukemia.
Leukemia. 2018 Dec 16. pii: 10.1038/s41375-018-0303.
PubMed Text format Abstract available

MODVIG S, Madsen HO, Siitonen SM, Rosthoj S, et al
Minimal residual disease quantification by flow cytometry provides reliable risk stratification in T-cell acute lymphoblastic leukemia.
Leukemia. 2018 Dec 14. pii: 10.1038/s41375-018-0307.
PubMed Text format Abstract available

SCHERR M, Kirchhoff H, Battmer K, Wohlan K, et al
Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia.
Leukemia. 2018 Dec 13. pii: 10.1038/s41375-018-0315.
PubMed Text format Abstract available

ANDERSEN MA, Moser CE, Lundgren J, Niemann CU, et al
Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study.
Leukemia. 2018 Dec 13. pii: 10.1038/s41375-018-0316.
PubMed Text format Abstract available

ZEIJLEMAKER W, Grob T, Meijer R, Hanekamp D, et al
CD34(+)CD38(-) leukemic stem cell frequency to predict outcome in acute myeloid leukemia.
Leukemia. 2018 Dec 12. pii: 10.1038/s41375-018-0326.
PubMed Text format Abstract available

HU X, Xu S, Chen Y, Gao Z, et al
Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis.
Leukemia. 2018 Dec 5. pii: 10.1038/s41375-018-0301.
PubMed Text format Abstract available

November 2018

BLAGITKO-DORFS N, Schlosser P, Greve G, Pfeifer D, et al
Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation.
Leukemia. 2018 Nov 23. pii: 10.1038/s41375-018-0293.
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October 2018

CAESER R, Collord G, Yao WQ, Chen Z, et al
Targeting MEK in vemurafenib-resistant hairy cell leukemia.
Leukemia. 2018 Oct 19. pii: 10.1038/s41375-018-0270.
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KRAFT B, Lombard J, Kirsch M, Wuchter P, et al
SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia.
Leukemia. 2018 Oct 15. pii: 10.1038/s41375-018-0287.
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FRASER G, Cramer P, Demirkan F, Silva RS, et al
Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma.
Leukemia. 2018 Oct 12. pii: 10.1038/s41375-018-0276.
PubMed Text format Abstract available

OTHUS M, Sekeres MA, Nand S, Garcia-Manero G, et al
Relative survival following response to 7 + 3 versus azacytidine is similar in acute myeloid leukemia and high-risk myelodysplastic syndromes: an analysis of four SWOG studies.
Leukemia. 2018 Oct 12. pii: 10.1038/s41375-018-0275.
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OTHUS M, Estey EH, Garcia-Manero G, Wood BL, et al
Second cycle remission achievement with 7+3 and survival in adults with newly diagnosed acute myeloid leukemia: analysis of recent SWOG trials.
Leukemia. 2018 Oct 12. pii: 10.1038/s41375-018-0274.
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ROSS DM, Pagani IS, Shanmuganathan N, Kok CH, et al
Long-term treatment-free remission of chronic myeloid leukemia with falling levels of residual leukemic cells.
Leukemia. 2018 Oct 12. pii: 10.1038/s41375-018-0264.
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MANSO BA, Zhang H, Mikkelson MG, Gwin KA, et al
Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients.
Leukemia. 2018 Oct 5. pii: 10.1038/s41375-018-0280.
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YAN B, Chen Q, Shimada K, Tang M, et al
Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia.
Leukemia. 2018 Oct 5. pii: 10.1038/s41375-018-0279.
PubMed Text format Abstract available

WALKER CJ, Oakes CC, Genutis LK, Giacopelli B, et al
Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA.
Leukemia. 2018 Oct 5. pii: 10.1038/s41375-018-0281.
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BRAESS J, Amler S, Kreuzer KA, Spiekermann K, et al
Sequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia-a phase 3 study.
Leukemia. 2018 Oct 1. pii: 10.1038/s41375-018-0268.
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DOHNER H, Dolnik A, Tang L, Seymour JF, et al
Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care.
Leukemia. 2018 Oct 1. pii: 10.1038/s41375-018-0257.
PubMed Text format Abstract available

VANDEPOELE K, Van der Meulen J, Denys B
The NF1 hotspot in acute myeloid leukemia: what's in a name?
Leukemia. 2018 Oct 1. pii: 10.1038/s41375-018-0266.
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September 2018

BHOJWANI D, Sposto R, Shah NN, Rodriguez V, et al
Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia.
Leukemia. 2018 Sep 28. pii: 10.1038/s41375-018-0265.
PubMed Text format Abstract available

HANNA BS, Roessner PM, Yazdanparast H, Colomer D, et al
Control of chronic lymphocytic leukemia development by clonally-expanded CD8(+) T-cells that undergo functional exhaustion in secondary lymphoid tissues.
Leukemia. 2018 Sep 28. pii: 10.1038/s41375-018-0250.
PubMed Text format Abstract available

MAEKAWA T, Osawa Y, Izumi T, Nagao S, et al
Correction: Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.
Leukemia. 2018 Sep 19. pii: 10.1038/s41375-018-0237.
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DEGRYSE S, de Bock CE, Demeyer S, Govaerts I, et al
Correction: Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.
Leukemia. 2018 Sep 19. pii: 10.1038/s41375-018-0241.
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PRIETO C, Lopez-Millan B, Roca-Ho H, Stam RW, et al
Correction: NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL.
Leukemia. 2018 Sep 14. pii: 10.1038/s41375-018-0236.
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KLUPSCH K, Baeriswyl V, Scholz R, Dannenberg J, et al
COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia.
Leukemia. 2018 Sep 11. pii: 10.1038/s41375-018-0249.
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MOUJALLED DM, Pomilio G, Ghiurau C, Ivey A, et al
Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia.
Leukemia. 2018 Sep 10. pii: 10.1038/s41375-018-0261.
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AGHEL N, Delgado DH, Lipton JH
Cardiovascular events in chronic myeloid leukemia clinical trials. Is it time to reassess and report the events according to cardiology guidelines?
Leukemia. 2018 Sep 10. pii: 10.1038/s41375-018-0247.
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August 2018

TAKESHITA A, Asou N, Atsuta Y, Sakura T, et al
Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study.
Leukemia. 2018 Aug 9. pii: 10.1038/s41375-018-0233.
PubMed Text format Abstract available

DUPLOYEZ N, Marceau-Renaut A, Villenet C, Petit A, et al
The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia.
Leukemia. 2018 Aug 8. pii: 10.1038/s41375-018-0227.
PubMed Text format Abstract available

PATNAIK MM, Tefferi A, Garcia-Manero G
Blast-phase chronic myelomonocytic leukemia: more than just semantics.
Leukemia. 2018 Aug 7. pii: 10.1038/s41375-018-0228.
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KURTZ SE, Eide CA, Kaempf A, Mori M, et al
Dual inhibition of JAK1/2 kinases and BCL2: a promising therapeutic strategy for acute myeloid leukemia.
Leukemia. 2018 Aug 6. pii: 10.1038/s41375-018-0225.
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July 2018

LEEKSMA AC, Taylor J, Wu B, Gardner JR, et al
Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia.
Leukemia. 2018 Jul 23. pii: 10.1038/s41375-018-0215.
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KREITMAN RJ, Dearden C, Zinzani PL, Delgado J, et al
Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia.
Leukemia. 2018 Jul 20. pii: 10.1038/s41375-018-0210.
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ALDOSS I, Capelletti M, Park J, Pistofidis RS, et al
Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma.
Leukemia. 2018 Jul 19. pii: 10.1038/s41375-018-0213.
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CICCONI L, Fenaux P, Kantarjian H, Tallman M, et al
Molecular remission as a therapeutic objective in acute promyelocytic leukemia.
Leukemia. 2018 Jul 19. pii: 10.1038/s41375-018-0219.
PubMed Text format Abstract available

LI Z, He S, Look AT
The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells.
Leukemia. 2018 Jul 15. pii: 10.1038/s41375-018-0201.
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L'ABBATE A, Tolomeo D, Cifola I, Severgnini M, et al
Correction: MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences.
Leukemia. 2018 Jul 9. pii: 10.1038/s41375-018-0177.
PubMed Text format Abstract available

STUDD JB, Yang M, Li Z, Vijayakrishnan J, et al
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism.
Leukemia. 2018 Jul 6. pii: 10.1038/s41375-018-0184.
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LUNDIN-STROM KB, Biloglav A, Lilljebjorn H, Rissler M, et al
Whole-exome sequencing exploration of acquired uniparental disomies in B-cell precursor acute lymphoblastic leukemia.
Leukemia. 2018 Jul 2. pii: 10.1038/s41375-018-0191.
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June 2018

VICENTE-DUENAS C, Gonzalez-Herrero I, Sehgal L, Garcia-Ramirez I, et al
Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia.
Leukemia. 2018 Jun 28. pii: 10.1038/s41375-018-0192.
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MARGOLSKEE E
So-called "blast phase" of chronic myelomonocytic leukemia: a plea for uniform terminology.
Leukemia. 2018 Jun 28. pii: 10.1038/s41375-018-0186.
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BOND J, Labis E, Marceau-Renaut A, Duployez N, et al
Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia.
Leukemia. 2018 Jun 27. pii: 10.1038/s41375-018-0187.
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HOLMQVIST AS, Chen Y, Wu J, Kung M, et al
Late mortality after allogeneic blood or marrow transplantation in childhood for leukemia: a report from the Blood or Marrow Transplant Survivor Study-2.
Leukemia. 2018 Jun 26. pii: 10.1038/s41375-018-0171.
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CRIADO I, Blanco E, Rodriguez-Caballero A, Alcoceba M, et al
Residual normal B-cell profiles in monoclonal B-cell lymphocytosis versus chronic lymphocytic leukemia.
Leukemia. 2018 Jun 21. pii: 10.1038/s41375-018-0164.
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SUTTORP M, Schulze P, Glauche I, Gohring G, et al
Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial.
Leukemia. 2018 Jun 20. pii: 10.1038/s41375-018-0179.
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GEBHARD C, Glatz D, Schwarzfischer L, Wimmer J, et al
Profiling of aberrant DNA methylation in acute myeloid leukemia reveals subclasses of CG-rich regions with epigenetic or genetic association.
Leukemia. 2018 Jun 20. pii: 10.1038/s41375-018-0165.
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ERNST T, Busch M, Rinke J, Ernst J, et al
Frequent ASXL1 mutations in children and young adults with chronic myeloid leukemia.
Leukemia. 2018 Jun 13. pii: 10.1038/s41375-018-0157.
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BODDU P, Gurguis C, Sanford D, Cortes J, et al
Response kinetics and factors predicting survival in core-binding factor leukemia.
Leukemia. 2018 Jun 8. pii: 10.1038/s41375-018-0158.
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BOUDREAUX SP, Duren RP, Call SG, Nguyen L, et al
Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia.
Leukemia. 2018 Jun 8. pii: 10.1038/s41375-018-0174.
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TASIAN SK, Casas JA, Posocco D, Gandre-Babbe S, et al
Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells.
Leukemia. 2018 Jun 8. pii: 10.1038/s41375-018-0169.
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TIMILSHINA N, Breunis H, Tomlinson GA, Brandwein JM, et al
Long-term recovery of quality of life and physical function over three years in adult survivors of acute myeloid leukemia after intensive chemotherapy.
Leukemia. 2018 Jun 8. pii: 10.1038/s41375-018-0162.
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BARGHOUT SH, Patel PS, Wang X, Xu GW, et al
Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia.
Leukemia. 2018 Jun 8. pii: 10.1038/s41375-018-0167.
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EISFELD AK, Kohlschmidt J, Mrozek K, Mims A, et al
NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome.
Leukemia. 2018 Jun 5. pii: 10.1038/s41375-018-0147.
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DONG X, Zhang W, Wu H, Huang J, et al
Structural basis of DUX4/IGH-driven transactivation.
Leukemia. 2018;32:1466-1476.
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INOUE D, Fujino T, Sheridan P, Zhang YZ, et al
A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
Leukemia. 2018;32:1327-1337.
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VERBIEST T, Finnon R, Brown N, Cruz-Garcia L, et al
Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis.
Leukemia. 2018;32:1435-1444.
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ZHENG L, Xu L, Xu Q, Yu L, et al
Utx loss causes myeloid transformation.
Leukemia. 2018;32:1458-1465.
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May 2018

CHEUNG LC, Tickner J, Hughes AM, Skut P, et al
New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment.
Leukemia. 2018 May 8. pii: 10.1038/s41375-018-0144.
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MEGGENDORFER M, Cappelli LV, Walter W, Haferlach C, et al
IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies.
Leukemia. 2018;32:1249-1253.
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DAVIDSSON J, Puschmann A, Tedgard U, Bryder D, et al
SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.
Leukemia. 2018;32:1106-1115.
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ZHENG W, O'Hear CE, Alli R, Basham JH, et al
PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells.
Leukemia. 2018;32:1157-1167.
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JETANI H, Garcia-Cadenas I, Nerreter T, Thomas S, et al
CAR T-cells targeting FLT3 have potent activity against FLT3(-)ITD(+) AML and act synergistically with the FLT3-inhibitor crenolanib.
Leukemia. 2018;32:1168-1179.
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ZAMPINI M, Tregnago C, Bisio V, Simula L, et al
Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML.
Leukemia. 2018;32:1124-1134.
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WONG ACH, Rasko JEJ, Wong JJ
We skip to work: alternative splicing in normal and malignant myelopoiesis.
Leukemia. 2018;32:1081-1093.
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TEFFERI A, Mudireddy M, Mannelli F, Begna KH, et al
Blast phase myeloproliferative neoplasm: Mayo-AGIMM study of 410 patients from two separate cohorts.
Leukemia. 2018;32:1200-1210.
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April 2018

PATNAIK MM, Pierola AA, Vallapureddy R, Yalniz FF, et al
Blast phase chronic myelomonocytic leukemia: Mayo-MDACC collaborative study of 171 cases.
Leukemia. 2018 Apr 25. pii: 10.1038/s41375-018-0143.
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HUITING LN, Samaha Y, Zhang GL, Roderick JE, et al
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response.
Leukemia. 2018 Apr 25. pii: 10.1038/s41375-018-0141.
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XIAO W, Rampal R, Zhang Y, Cimera R, et al
JAK/MAP kinase pathway activation and TP53 mutations in acute leukemia with megakaryocytic and erythroid differentiation.
Leukemia. 2018 Apr 24. pii: 10.1038/s41375-018-0145.
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KAYSER S, Schlenk RF, Platzbecker U
Management of patients with acute promyelocytic leukemia.
Leukemia. 2018 Apr 24. pii: 10.1038/s41375-018-0139.
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GARCIA EG, Iyer S, Garcia SP, Loontiens S, et al
Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia.
Leukemia. 2018 Apr 18. pii: 10.1038/s41375-018-0130.
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RENNEVILLE A, Attias P, Thomas X, Bally C, et al
Genetic analysis of therapy-related myeloid neoplasms occurring after intensive treatment for acute promyelocytic leukemia.
Leukemia. 2018 Apr 18. pii: 10.1038/s41375-018-0137.
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DE BIE J, Demeyer S, Alberti-Servera L, Geerdens E, et al
Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.
Leukemia. 2018 Apr 18. pii: 10.1038/s41375-018-0127.
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PASCHKA P, Schlenk RF, Weber D, Benner A, et al
Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia-results of the AMLSG 11-08 trial.
Leukemia. 2018 Apr 17. pii: 10.1038/s41375-018-0129.
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STUDENCKA-TURSKI M, Maubach G, Feige MH, Naumann M, et al
Constitutive activation of nuclear factor kappa B-inducing kinase counteracts apoptosis in cells with rearranged mixed lineage leukemia gene.
Leukemia. 2018 Apr 17. pii: 10.1038/s41375-018-0128.
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WARTIOVAARA-KAUTTO U, Hirvonen EAM, Pitkanen E, Heckman C, et al
Germline alterations in a consecutive series of acute myeloid leukemia.
Leukemia. 2018 Apr 10. pii: 10.1038/s41375-018-0049.
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CASADO P, Wilkes EH, Miraki-Moud F, Hadi MM, et al
Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells.
Leukemia. 2018 Apr 7. pii: 10.1038/s41375-018-0032.
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HU T, Wu Q, Chong Y, Qin H, et al
FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome.
Leukemia. 2018 Apr 2. pii: 10.1038/s41375-018-0124.
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PATNAIK MM, Rangit Vallapureddy, Lasho TL, Hoversten KP, et al
A comparison of clinical and molecular characteristics of patients with systemic mastocytosis with chronic myelomonocytic leukemia to CMML alone.
Leukemia. 2018 Apr 2. pii: 10.1038/s41375-018-0121.
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PETER B, Bibi S, Eisenwort G, Wingelhofer B, et al
Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.
Leukemia. 2018;32:1016-1022.
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MAURA F, Petljak M, Lionetti M, Cifola I, et al
Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.
Leukemia. 2018;32:1044-1048.
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SANARICO AG, Ronchini C, Croce A, Memmi EM, et al
The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia.
Leukemia. 2018;32:911-919.
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MARSILIO S, Khiabanian H, Fabbri G, Vergani S, et al
Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity.
Leukemia. 2018;32:1041-1044.
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March 2018

HOSSEINI MM, Kurtz SE, Abdelhamed S, Mahmood S, et al
Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.
Leukemia. 2018 Mar 29. pii: 10.1038/s41375-018-0112.
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THAN H, Qiao Y, Huang X, Yan D, et al
Ongoing clonal evolution in chronic myelomonocytic leukemia on hypomethylating agents: a computational perspective.
Leukemia. 2018 Mar 27. pii: 10.1038/s41375-018-0050.
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HOJJAT-FARSANGI M, Daneshmanesh AH, Khan AS, Shetye J, et al
First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells.
Leukemia. 2018 Mar 27. pii: 10.1038/s41375-018-0113.
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THI NGOC PC, Tan SH, Tan TK, Chan MM, et al
Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.
Leukemia. 2018 Mar 26. pii: 10.1038/s41375-018-0110.
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GHIA P, Rawstron A
Minimal residual disease analysis in chronic lymphocytic leukemia: a way for achieving more personalized treatments.
Leukemia. 2018 Mar 26. pii: 10.1038/s41375-018-0109.
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KUCHENBAUER F, Buske C
Revisiting thrombocytopenia in acute promyelocytic leukemia.
Leukemia. 2018 Mar 23. pii: 10.1038/s41375-018-0105.
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RUDAT S, Pfaus A, Cheng YY, Holtmann J, et al
RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia.
Leukemia. 2018 Mar 22. pii: 10.1038/s41375-018-0102.
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GENTILE M, Shanafelt TD, Reda G, Mauro FR, et al
Validation of a biological score to predict response in chronic lymphocytic leukemia patients treated front-line with bendamustine and rituximab.
Leukemia. 2018 Mar 20. pii: 10.1038/s41375-018-0100.
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BURNS MA, Liao ZW, Yamagata N, Pouliot GP, et al
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.
Leukemia. 2018 Mar 20. pii: 10.1038/s41375-018-0097.
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SUN W, Malvar J, Sposto R, Verma A, et al
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
Leukemia. 2018 Mar 15. pii: 10.1038/s41375-018-0094.
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QIN YZ, Huang XJ, Zhu HH
Identification of a novel CPSF6-RARG fusion transcript in acute myeloid leukemia resembling acute promyelocytic leukemia.
Leukemia. 2018 Mar 14. pii: 10.1038/s41375-018-0095.
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GUNNARSSON R, Dilorenzo S, Lundin-Strom KB, Olsson L, et al
Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia.
Leukemia. 2018 Mar 12. pii: 10.1038/s41375-018-0092.
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KELLY AD, Madzo J, Madireddi P, Kropf P, et al
Demethylator phenotypes in acute myeloid leukemia.
Leukemia. 2018 Mar 7. pii: 10.1038/s41375-018-0084.
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GERBOTH S, Frittoli E, Palamidessi A, Baltanas FC, et al
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Leukemia. 2018;32:820-827.
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ANDERSSON EI, Putzer S, Yadav B, Dufva O, et al
Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.
Leukemia. 2018;32:774-787.
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February 2018

TAWANA K, Drazer MW, Churpek JE
Universal genetic testing for inherited susceptibility in children and adults with myelodysplastic syndrome and acute myeloid leukemia: are we there yet?
Leukemia. 2018 Feb 27. pii: 10.1038/s41375-018-0051.
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MARUFFI M, Sposto R, Oberley MJ, Kysh L, et al
Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis.
Leukemia. 2018 Feb 27. pii: 10.1038/s41375-018-0058.
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SAUSSELE S, Hehlmann R, Fabarius A, Jeromin S, et al
Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV.
Leukemia. 2018 Feb 26. pii: 10.1038/s41375-018-0055.
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ALI A, Penneroux J, Dal Bello R Jr, Masse A, et al
Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia.
Leukemia. 2018 Feb 26. pii: 10.1038/s41375-018-0076.
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PETROV JC, Wada M, Pinz KG, Yan LE, et al
Compound CAR T-cells as a double-pronged approach for treating acute myeloid leukemia.
Leukemia. 2018 Feb 25. pii: 10.1038/s41375-018-0075.
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HNIZDA A, Fabry M, Moriyama T, Pachl P, et al
Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia. 2018 Feb 25. pii: 10.1038/s41375-018-0073.
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EISFELD AK, Kohlschmidt J, Mrozek K, Blachly JS, et al
Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: an analysis of Alliance studies.
Leukemia. 2018 Feb 25. pii: 10.1038/s41375-018-0068.
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BICCLER JL, Ostgard LSG, Severinsen MT, Marcher CW, et al
Evolution of relative survival for acute promyelocytic leukemia patients alive at landmark time-points: a population-based study.
Leukemia. 2018 Feb 23. pii: 10.1038/s41375-018-0054.
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ROTHENBERG-THURLEY M, Amler S, Goerlich D, Kohnke T, et al
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.
Leukemia. 2018 Feb 23. pii: 10.1038/s41375-018-0034.
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GUPTA S, Devidas M, Loh ML, Raetz EA, et al
Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group (COG).
Leukemia. 2018 Feb 23. pii: 10.1038/s41375-018-0039.
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FONTANA MC, Marconi G, Feenstra JDM, Fonzi E, et al
Chromothripsis in acute myeloid leukemia: biological features and impact on survival.
Leukemia. 2018 Feb 23. pii: 10.1038/s41375-018-0035.
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LAVALLEE VP, Chagraoui J, MacRae T, Marquis M, et al
Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.
Leukemia. 2018 Feb 23. pii: 10.1038/s41375-018-0069.
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DAVER N, Boddu P, Garcia-Manero G, Yadav SS, et al
Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes.
Leukemia. 2018 Feb 22. pii: 10.1038/s41375-018-0070.
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L ABBATE A, Tolomeo D, Cifola I, Severgnini M, et al
MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences.
Leukemia. 2018 Feb 22. pii: 10.1038/s41375-018-0033.
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RASCHE M, Zimmermann M, Borschel L, Bourquin JP, et al
Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012.
Leukemia. 2018 Feb 22. pii: 10.1038/s41375-018-0071.
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STRATI P, Ferrajoli A, Wierda WG, Jain N, et al
Sustained long-lasting responses after lenalidomide discontinuation in patients with chronic lymphocytic leukemia.
Leukemia. 2018 Feb 20. pii: 10.1038/s41375-018-0059.
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CRAMER SD, Hixon JA, Andrews C, Porter RJ, et al
Mutant IL-7Ralpha and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.
Leukemia. 2018 Feb 15. pii: 10.1038/s41375-017-0001.
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SUAREZ-GONZALEZ J, Martinez-Laperche C, Martinez N, Rodriguez-Macias G, et al
Whole-exome sequencing reveals acquisition of mutations leading to the onset of donor cell leukemia after hematopoietic transplantation: a model of leukemogenesis.
Leukemia. 2018 Feb 5. pii: 10.1038/s41375-018-0042.
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PENG D, Wang H, Li L, Ma X, et al
miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
Leukemia. 2018 Feb 2. pii: 10.1038/s41375-018-0015.
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LA STARZA R, Messina M, Gianfelici V, Pierini V, et al
High PIM1 expression is a biomarker of T-cell acute lymphoblastic leukemia with JAK/STAT activation or t(6;7)(p21;q34)/TRB@-PIM1 rearrangement.
Leukemia. 2018 Feb 2. pii: 10.1038/s41375-018-0031.
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WINGELHOFER B, Maurer B, Heyes EC, Cumaraswamy AA, et al
Pharmacologic inhibition of STAT5 in acute myeloid leukemia.
Leukemia. 2018 Feb 2. pii: 10.1038/s41375-017-0005.
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MALCIKOVA J, Tausch E, Rossi D, Sutton LA, et al
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation.
Leukemia. 2018 Feb 2. pii: 10.1038/s41375-017-0007.
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BALASUBRAMANIAN SK, Aly M, Nagata Y, Bat T, et al
Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.
Leukemia. 2018;32:550-553.
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KLYMENKO T, Bloehdorn J, Bahlo J, Robrecht S, et al
Lamin B1 regulates somatic mutations and progression of B-cell malignancies.
Leukemia. 2018;32:364-375.
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STENGEL A, Kern W, Meggendorfer M, Nadarajah N, et al
Number of RUNX1 mutations, wild-type allele loss and additional mutations impact on prognosis in adult RUNX1-mutated AML.
Leukemia. 2018;32:295-302.
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KUBESOVA B, Pavlova S, Malcikova J, Kabathova J, et al
Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status.
Leukemia. 2018;32:450-461.
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DEANGELO DJ, George TI, Linder A, Langford C, et al
Efficacy and safety of midostaurin in patients with advanced systemic mastocytosis: 10-year median follow-up of a phase II trial.
Leukemia. 2018;32:470-478.
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LIU E, Tong Y, Dotti G, Shaim H, et al
Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity.
Leukemia. 2018;32:520-531.
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MEYER C, Burmeister T, Groger D, Tsaur G, et al
The MLL recombinome of acute leukemias in 2017.
Leukemia. 2018;32:273-284.
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GARRIDO CASTRO P, van Roon EHJ, Pinhancos SS, Trentin L, et al
The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.
Leukemia. 2018;32:323-331.
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KAUSHIK S, Liu F, Veazey KJ, Gao G, et al
Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.
Leukemia. 2018;32:499-509.
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January 2018

SUN X, Ren Y, Gunawan S, Teng P, et al
Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099.
Leukemia. 2018 Jan 30. pii: 10.1038/s41375-018-0020.
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JO S, Lee JH, Mattei JJ, Barrett DM, et al
Generation of a multi-antigen-directed immune response for durable control of acute lymphoblastic leukemia.
Leukemia. 2018 Jan 5. pii: leu2017312. doi: 10.1038/leu.2017.
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PIETTE C, Suciu S, Clappier E, Bertrand Y, et al
Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials.
Leukemia. 2018;32:244-248.
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BUONTEMPO F, McCubrey JA, Orsini E, Ruzzene M, et al
Therapeutic targeting of CK2 in acute and chronic leukemias.
Leukemia. 2018;32:1-10.
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BRAZDILOVA K, Plevova K, Skuhrova Francova H, Kockova H, et al
Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL.
Leukemia. 2018;32:234-236.
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BODDU P, Jorgensen J, Kantarjian H, Borthakur G, et al
Achievement of a negative minimal residual disease state after hypomethylating agent therapy in older patients with AML reduces the risk of relapse.
Leukemia. 2018;32:241-244.
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GU S, Sayad A, Chan G, Yang W, et al
SHP2 is required for BCR-ABL1-induced hematologic neoplasia.
Leukemia. 2018;32:203-213.
PubMed Text format Abstract available

MINGAY M, Chaturvedi A, Bilenky M, Cao Q, et al
Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.
Leukemia. 2018;32:11-20.
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GOLE B, Mian E, Rall M, Wiesmuller L, et al
Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization.
Leukemia. 2018;32:159-167.
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BROWN JR, Hillmen P, O'Brien S, Barrientos JC, et al
Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL.
Leukemia. 2018;32:83-91.
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VILLARESE P, Lours C, Trinquand A, Le Noir S, et al
TCRalpha rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome.
Leukemia. 2018;32:61-71.
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SUN L, Shi Y, Wang G, Wang X, et al
PPAR-delta modulates membrane cholesterol and cytokine signaling in malignant B cells.
Leukemia. 2018;32:184-193.
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WELSH SJ, Churchman ML, Togni M, Mullighan CG, et al
Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis.
Leukemia. 2018;32:38-48.
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December 2017

GUPTA S, Devidas M, Loh ML, Raetz EA, et al
Flow cytometric vs morphologic assessment of remission in childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group (COG).
Leukemia. 2017 Dec 18. pii: leu2017341. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

BU J, Chen A, Yan X, He F, et al
SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.
Leukemia. 2017 Dec 18. pii: leu2017339. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

FONTANA MC, Marconi G, Feenstra JDM, Fonzi E, et al
Chromothripsis in acute myeloid leukemia: Biological features and impact on survival.
Leukemia. 2017 Dec 18. pii: leu2017351. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

ROTHENBERG-THURLEY M, Amler S, Goerlich D, Kohnke T, et al
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.
Leukemia. 2017 Dec 18. pii: leu2017350. doi: 10.1038/leu.2017.
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CASADO P, Wilkes EH, Miraki-Moud F, Hadi MM, et al
Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells.
Leukemia. 2017 Dec 12. pii: leu2017349. doi: 10.1038/leu.2017.
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TIRADO-GONZALEZ I, Czlonka E, Nevmerzhitskaya A, Soetopo D, et al
CRISPR/Cas9 edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.
Leukemia. 2017 Dec 6. pii: leu2017346. doi: 10.1038/leu.2017.
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DRIESSEN EMC, de Lorenzo P, Campbell M, Felice M, et al
Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol.
Leukemia. 2017;31:2854.
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GRZES KM, Swamy M, Hukelmann JL, Emslie E, et al
Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy.
Leukemia. 2017;31:2771-2779.
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GARCIA-MANERO G, Sekeres MA, Egyed M, Breccia M, et al
A phase 1b/2b multicenter study of oral panobinostat plus azacitidine in adults with MDS, CMML or AML with 30% blasts.
Leukemia. 2017;31:2799-2806.
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TESIO M, Trinquand A, Ballerini P, Hypolite G, et al
Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia.
Leukemia. 2017;31:2594-2600.
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ELDER A, Bomken S, Wilson I, Blair HJ, et al
Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia.
Leukemia. 2017;31:2577-2586.
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DELGADO-MARTIN C, Meyer LK, Huang BJ, Shimano KA, et al
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
Leukemia. 2017;31:2568-2576.
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RASCHE M, von Neuhoff C, Dworzak M, Bourquin JP, et al
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.
Leukemia. 2017;31:2807-2814.
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ZHANG H, Reister Schultz A, Luty S, Rofelty A, et al
Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.
Leukemia. 2017;31:2752-2760.
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LYU Y, Lou J, Yang Y, Feng J, et al
Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways.
Leukemia. 2017;31:2543-2551.
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YOKOTA A, Hirai H, Shoji T, Maekawa T, et al
Constitutively active ABL family kinases, TEL/ABL and TEL/ARG, harbor distinct leukemogenic activities in vivo.
Leukemia. 2017;31:2742-2751.
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November 2017

LABBATE A, Tolomeo D, Cifola I, Severgnini M, et al
MYC-containing amplicons in acute myeloid leukemia: Genomic structures, evolution, and transcriptional consequences.
Leukemia. 2017 Nov 28. pii: leu2017337. doi: 10.1038/leu.2017.
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NIMMAGADDA SC, Frey S, Edelmann B, Hellmich C, et al
Bruton's Tyrosine Kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia.
Leukemia. 2017 Nov 7. doi: 10.1038/leu.2017.
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LHERMITTE L, Mejstrikova E, van der Sluijs-Gelling AJ, Grigore GE, et al
Automated database-guided expert-supervised orientation for immunophenotypic diagnosis and classification of acute leukemia.
Leukemia. 2017 Nov 1. doi: 10.1038/leu.2017.
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WALF-VORDERWULBECKE V, Pearce K, Brooks T, Hubank M, et al
Targeting acute myeloid leukemia by drug-induced c-MYB degradation.
Leukemia. 2017 Nov 1. doi: 10.1038/leu.2017.
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HADZIJUSUFOVIC E, Albrecht-Schgoer K, Huber K, Hoermann G, et al
Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site.
Leukemia. 2017;31:2388-2397.
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PULIKKAN JA, Tenen DG, Behre G
C/EBPalpha deregulation as a paradigm for leukemogenesis.
Leukemia. 2017;31:2279-2285.
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LIU X, Rothe K, Yen R, Fruhstorfer C, et al
A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.
Leukemia. 2017;31:2376-2387.
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THIEL VN, Giaimo BD, Schwarz P, Soller K, et al
Heterodimerization of AML1/ETO with CBFbeta is required for leukemogenesis but not for myeloproliferation.
Leukemia. 2017;31:2491-2502.
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O'LEARY HA, Capitano M, Cooper S, Mantel C, et al
DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms.
Leukemia. 2017;31:2468-2478.
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HOWARD DR, Munir T, McParland L, Rawstron AC, et al
Results of the randomized phase IIB ARCTIC trial of low-dose rituximab in previously untreated CLL.
Leukemia. 2017;31:2416-2425.
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SAVINO AM, Sarno J, Trentin L, Vieri M, et al
The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.
Leukemia. 2017;31:2365-2375.
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KRAMER AC, Kothari A, Wilson WC, Celik H, et al
Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Leukemia. 2017;31:2479-2490.
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ABRAHAM M, Klein S, Bulvik B, Wald H, et al
The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
Leukemia. 2017;31:2336-2346.
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HA VL, Luong A, Li F, Casero D, et al
The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation.
Leukemia. 2017;31:2503-2514.
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DELL'AVERSANA C, Giorgio C, D'Amato L, Lania G, et al
miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.
Leukemia. 2017;31:2315-2325.
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October 2017

SAID B, Gilles S, Weisdorf D, Rashidi A, et al
The role of bone marrow morphology in the diagnosis of relapsed acute myeloid leukemia.
Leukemia. 2017 Oct 31. doi: 10.1038/leu.2017.
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YAN F, Shen N, Pang JX, Zhao N, et al
A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target.
Leukemia. 2017 Oct 10. doi: 10.1038/leu.2017.
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TOPP MS, Stelljes M, Zugmaier G, Barnette P, et al
Blinatumomab retreatment after relapse in patients with relapsed/refractory B-precursor acute lymphoblastic leukemia.
Leukemia. 2017 Oct 9. doi: 10.1038/leu.2017.
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JERCHEL IS, Hoogkamer AQ, Aries IM, Steeghs EMP, et al
RAS pathway mutations as predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia.
Leukemia. 2017 Oct 3. doi: 10.1038/leu.2017.
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LI Z, Abraham BJ, Berezovskaya A, Farah N, et al
APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL.
Leukemia. 2017;31:2057-2064.
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MUNIR T, Howard DR, McParland L, Pocock C, et al
Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL.
Leukemia. 2017;31:2085-2093.
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JU HQ, Zhan G, Huang A, Sun Y, et al
ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition.
Leukemia. 2017;31:2143-2150.
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DUELL J, Dittrich M, Bedke T, Mueller T, et al
Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL.
Leukemia. 2017;31:2181-2190.
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CHEN KH, Wada M, Pinz KG, Liu H, et al
Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor.
Leukemia. 2017;31:2151-2160.
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September 2017

FUJITA S, Honma D, Adachi N, Araki K, et al
Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia.
Leukemia. 2017 Sep 27. doi: 10.1038/leu.2017.
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PRIETO C, Lopez-Millan B, Roca-Ho H, Stam RW, et al
NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL.
Leukemia. 2017 Sep 25. doi: 10.1038/leu.2017.
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BENEDETTI D, Tissino E, Pozzo F, Bittolo T, et al
NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: Link between the NOTCH1 and the NF-kB pathways.
Leukemia. 2017 Sep 22. doi: 10.1038/leu.2017.
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JO S, Lee JH, Mattei JJ, Barrett DM, et al
Generation of a multi-antigen-directed immune response for durable control of acute lymphoblastic leukemia.
Leukemia. 2017 Sep 19. doi: 10.1038/leu.2017.
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DEL GIUDICE I, Rigolin GM, Raponi S, Cafforio L, et al
Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low and very-low risk genetic profile.
Leukemia. 2017 Sep 19. doi: 10.1038/leu.2017.
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NADEU F, Clot G, Delgado J, Martin-Garcia D, et al
Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia.
Leukemia. 2017 Sep 19. doi: 10.1038/leu.2017.
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HOSPITAL MA, Jacquel A, Mazed F, Saland E, et al
RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.
Leukemia. 2017 Sep 15. doi: 10.1038/leu.2017.
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SAKURA T, Hayakawa F, Sugiura I, Murayama T, et al
High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: A phase III study by JALSG.
Leukemia. 2017 Sep 15. doi: 10.1038/leu.2017.
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WAIBEL M, Vervoort SJ, Kong IY, Heinzel S, et al
Epigenetic targeting of Notch1 driven transcription using the HDACi panobinostat is a potential therapy against T cell acute lymphoblastic leukemia.
Leukemia. 2017 Sep 15. doi: 10.1038/leu.2017.
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TAKAO S, Chien W, Madan V, Lin DC, et al
Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.
Leukemia. 2017 Sep 14. doi: 10.1038/leu.2017.
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MARNETH AE, Prange KHM, Al Hinai ASA, Bergevoet SM, et al
C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.
Leukemia. 2017 Sep 5. doi: 10.1038/leu.2017.
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RINKE J, Muller JP, Blaess MF, Chase A, et al
Molecular characterization of EZH2 mutant patients with myelodysplastic/myeloproliferative neoplasms.
Leukemia. 2017;31:1936-1943.
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KIM T, Tyndel MS, Kim HJ, Ahn JS, et al
The clonal origins of leukemic progression of myelodysplasia.
Leukemia. 2017;31:1928-1935.
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SAENZ DT, Fiskus W, Qian Y, Manshouri T, et al
Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells.
Leukemia. 2017;31:1951-1961.
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RONCHINI C, Brozzi A, Riva L, Luzi L, et al
PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias.
Leukemia. 2017;31:1975-1986.
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August 2017

DEGRYSE S, de Bock CE, Demeyer S, Govaerts I, et al
Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.
Leukemia. 2017 Aug 30. doi: 10.1038/leu.2017.
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JYOTSANA N, Sharma A, Chaturvedi A, Scherr M, et al
RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.
Leukemia. 2017 Aug 22. doi: 10.1038/leu.2017.
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ZHAO L, Alkadi H, Kwon EM, Zhen T, et al
The C-terminal multimerization domain is essential for leukemia development by CBFbeta-SMMHC in a mouse knockin model.
Leukemia. 2017 Aug 18. doi: 10.1038/leu.2017.
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TOFT N, Birgens H, Abrahamsson J, Griskevicius L, et al
Results of NOPHO ALL2008 treatment for patients 1-45 years with acute lymphoblastic leukemia.
Leukemia. 2017 Aug 18. doi: 10.1038/leu.2017.
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PENA-MARTINEZ P, Eriksson M, Ramakrishnan R, Chapellier M, et al
Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6 dependent manner.
Leukemia. 2017 Aug 18. doi: 10.1038/leu.2017.
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KUMAR B, Garcia M, Weng L, Jung X, et al
Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion.
Leukemia. 2017 Aug 17. doi: 10.1038/leu.2017.
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ARTESI M, Marcais A, Durkin K, Rosewick N, et al
Monitoring molecular response in adult t-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality.
Leukemia. 2017 Aug 16. doi: 10.1038/leu.2017.
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HOECHSTETTER MA, Busch R, Eichhorst B, Buhler A, et al
Early, risk-adapted treatment with fludarabine in binet stage a chronic lymphocytic leukemia patients: Results of the CLL1 trial of the German CLL study group.
Leukemia. 2017 Aug 14. doi: 10.1038/leu.2017.
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HEHLMANN R, Lauseker M, Saussele S, Pfirrmann M, et al
Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants.
Leukemia. 2017 Aug 14. doi: 10.1038/leu.2017.
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REITER K, Polzer H, Krupka C, Maiser A, et al
Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.
Leukemia. 2017 Aug 14. doi: 10.1038/leu.2017.
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MASCIARELLI S, Capuano E, Ottone T, Divona M, et al
'Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress'.
Leukemia. 2017 Aug 4. doi: 10.1038/leu.2017.
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RAFIQ S, Purdon TJ, Daniyan AF, Koneru M, et al
Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen.
Leukemia. 2017;31:1788-1797.
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DRENNAN S, D'Avola A, Gao Y, Weigel C, et al
IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.
Leukemia. 2017;31:1686-1694.
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July 2017

KIM HG, LeGrand J, Swindle CS, Nick HJ, et al
The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia.
Leukemia. 2017 Jul 28. doi: 10.1038/leu.2017.
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YIGIT B, Wang N, Chen SS, Chiorazzi N, et al
Inhibition of Reactive oxygen species (ROS) limits expansion of chronic lymphocytic leukemia cells.
Leukemia. 2017 Jul 28. doi: 10.1038/leu.2017.
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TEH TC, Nguyen NY, Moujalled DM, Segal D, et al
Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.
Leukemia. 2017 Jul 28. doi: 10.1038/leu.2017.
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GIRARDI T, Vereecke S, Sulima SO, Khan Y, et al
The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.
Leukemia. 2017 Jul 24. doi: 10.1038/leu.2017.
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XIA F, Zhang Y, Xie L, Jiang H, et al
B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways.
Leukemia. 2017 Jul 24. doi: 10.1038/leu.2017.
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SOPPER S, Mustjoki S, Gjertsen BT, Giles F, et al
NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib.
Leukemia. 2017 Jul 24. doi: 10.1038/leu.2017.
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AL-SAWAF O, Robrecht S, Bahlo J, Fink AM, et al
Impact of gender on outcome after chemoimmunotherapy in patients with chronic lymphocytic leukemia: a meta-analysis by the German CLL study group.
Leukemia. 2017 Jul 12. doi: 10.1038/leu.2017.
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BECK D, Thoms JAI, Palu C, Herold T, et al
A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.
Leukemia. 2017 Jul 4. doi: 10.1038/leu.2017.
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HOURIGAN CS, Gale RP, Gormley NJ, Ossenkoppele GJ, et al
Measurable residual disease testing in acute myeloid leukaemia.
Leukemia. 2017;31:1482-1490.
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CUTLER JA, Tahir R, Sreenivasamurthy SK, Mitchell C, et al
Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis.
Leukemia. 2017;31:1513-1524.
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RIBEIRO ST, Tesio M, Ribot JC, Macintyre E, et al
Casein kinase 2 controls the survival of normal thymic and leukemic gammadelta T cells via promotion of AKT signaling.
Leukemia. 2017;31:1603-1610.
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June 2017

ANGENENDT L, Reuter S, Kentrup D, Benk AS, et al
An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia.
Leukemia. 2017 Jun 30. doi: 10.1038/leu.2017.
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YABE T, Azuma F, Kashiwase K, Matsumoto K, et al
HLA-DPB1 mismatch induces a graft-versus-leukemia (GVL) effect without severe acute GVHD after single-unit umbilical cord blood transplantation.
Leukemia. 2017 Jun 27. doi: 10.1038/leu.2017.
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TIAO G, Improgo MR, Kasar S, Poh W, et al
Rare germline variants in ATM are associated with chronic lymphocytic leukemia.
Leukemia. 2017 Jun 27. doi: 10.1038/leu.2017.
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GAIDZIK VI, Weber D, Paschka P, Kaumanns A, et al
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.
Leukemia. 2017 Jun 23. doi: 10.1038/leu.2017.
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ZHANG Q, Ball MC, Zhao Y, Balasis M, et al
Intrapatient functional clonality deconvoluted by coupling intracellular flow cytometry and next-generation sequencing in human leukemia.
Leukemia. 2017 Jun 21. doi: 10.1038/leu.2017.
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RIO-MACHIN A, Gomez-Lopez G, Munoz J, Garcia-Martinez F, et al
The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia.
Leukemia. 2017 Jun 20. doi: 10.1038/leu.2017.
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GODWIN CD, Gale RP, Walter RB
Gemtuzumab ozogamicin in acute myeloid leukemia.
Leukemia. 2017 Jun 13. doi: 10.1038/leu.2017.
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SANTINI V, Allione B, Zini G, Gioia D, et al
A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia.
Leukemia. 2017 Jun 13. doi: 10.1038/leu.2017.
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BURNS A, Alsolami R, Becq J, Timbs A, et al
Whole genome sequencing of chronic lymphocytic leukemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups.
Leukemia. 2017 Jun 6. doi: 10.1038/leu.2017.
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MARTINEZ-CUADRON D, Montesinos P, Vellenga E, Bernal T, et al
Long-term outcome of older patients with newly diagnosed de novo acute promyelocytic leukemia treated with ATRA plus anthracycline-based therapy.
Leukemia. 2017 Jun 6. doi: 10.1038/leu.2017.
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PROMOD ST, Johnson DP, Bennett SE, Dennis EM, et al
HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
Leukemia. 2017 Jun 5. doi: 10.1038/leu.2017.
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HAHN M, Burckert JP, Luttenberger CA, Klebow S, et al
Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-kappaB signaling.
Leukemia. 2017 Jun 1. doi: 10.1038/leu.2017.
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USTUN C, Giannotti F, Zhang MJ, Wang HL, et al
Outcomes of UCB transplantation are comparable in FLT3+ AML: results of CIBMTR, EUROCORD and EBMT collaborative analysis.
Leukemia. 2017;31:1408-1414.
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HERNDON TM, Chen SS, Saba NS, Valdez J, et al
Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood.
Leukemia. 2017;31:1340-1347.
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YAN F, Shen N, Pang JX, Zhang YW, et al
Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells.
Leukemia. 2017;31:1434-1442.
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CHENG G, Liu F, Asai T, Lai F, et al
Loss of p300 accelerates MDS-associated leukemogenesis.
Leukemia. 2017;31:1382-1390.
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RODMAN C, Almeida-Porada G, George SK, Moon J, et al
In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells.
Leukemia. 2017;31:1398-1407.
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CARTER MJ, Cox KL, Blakemore SJ, Turaj AH, et al
PI3Kdelta inhibition elicits anti-leukemic effects through Bim-dependent apoptosis.
Leukemia. 2017;31:1423-1433.
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May 2017

HALPERN AB, Othus M, Huebner EM, Buckley SA, et al
Mitoxantrone, etoposide, and cytarabine (MEC) following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms: A phase 1/2 study.
Leukemia. 2017 May 30. doi: 10.1038/leu.2017.
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HA JS, Do YR, Ki CS, Lee C, et al
Identification of a novel PML-RARG fusion in acute promyelocytic leukemia.
Leukemia. 2017 May 30. doi: 10.1038/leu.2017.
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PATEL B, Przychodzen B, Thota S, Radivoyevitch T, et al
Genomic determinants of chronic myelomonocytic leukemia.
Leukemia. 2017 May 30. doi: 10.1038/leu.2017.
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HEILMANN AM, Schrock AB, He J, Nahas M, et al
Novel PDGFRB fusions in childhood B and T acute lymphoblastic leukemia.
Leukemia. 2017 May 29. doi: 10.1038/leu.2017.
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MA Z, Zhao X, Huang J, Jia X, et al
A critical role of periostin in B-cell acute lymphoblastic leukemia.
Leukemia. 2017 May 22. doi: 10.1038/leu.2017.
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BERNSON E, Hallner A, Sander FE, Wilsson O, et al
Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia.
Leukemia. 2017 May 22. doi: 10.1038/leu.2017.
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HINZE L, Moricke A, Zimmermann M, Junk S, et al
Prognostic impact of IKZF1 deletions in association with vincristine-dexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial ALL-BFM 95.
Leukemia. 2017 May 22. doi: 10.1038/leu.2017.
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CHEN L, Mao H, Zhang J, Chu J, et al
Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia.
Leukemia. 2017 May 12. doi: 10.1038/leu.2017.
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PAN J, Yang J, Deng B, Zhao X, et al
High efficacy and safety of low dose CD19-directed CAR-T cell therapy in 51 refractory or relapsed B acute lymphoblastic leukemia patients.
Leukemia. 2017 May 11. doi: 10.1038/leu.2017.
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ROSSETTI C, Picardi E, Ye M, Camilli G, et al
RNA editing signature during myeloid leukemia cell differentiation.
Leukemia. 2017 May 9. doi: 10.1038/leu.2017.
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HASAN K, Yu J, Chen L, Cui B, et al
Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells.
Leukemia. 2017 May 3. doi: 10.1038/leu.2017.
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YU J, Chen L, Chen Y, Hasan K, et al
Wnt5a induces ROR1 to associate with 14-3-3zeta for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells.
Leukemia. 2017 May 3. doi: 10.1038/leu.2017.
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SLINGER E, Thijssen R, Kater AP, Eldering E, et al
Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition.
Leukemia. 2017 May 2. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

LONG J, Fang WY, Chang L, Gao WH, et al
Targeting HDAC3, new partner protein of AKT in the reversal of chemo-resistance in acute myeloid leukemia via DNA damage response.
Leukemia. 2017 May 2. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

GUNNARSSON N, Hoglund M, Stenke L, Sandin F, et al
No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia-a population-based study in Sweden.
Leukemia. 2017 May 2. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

EIRING AM, Page BDG, Kraft IL, Mason CC, et al
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.
Leukemia. 2017;31:1253-1254.
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LEROY E, Constantinescu SN
Rethinking JAK2 inhibition: towards novel strategies of more specific and versatile janus kinase inhibition.
Leukemia. 2017;31:1023-1038.
PubMed Text format Abstract available

KAZIANKA L, Drucker C, Skrabs C, Thomas W, et al
Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib.
Leukemia. 2017;31:1117-1122.
PubMed Text format Abstract available

MALANI D, Murumagi A, Yadav B, Kontro M, et al
Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML.
Leukemia. 2017;31:1187-1195.
PubMed Text format Abstract available

LIU TH, Tang YJ, Huang Y, Wang L, et al
Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
Leukemia. 2017;31:1079-1086.
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April 2017

CAZZANIGA G, Bisanti L, Randi G, Deandrea S, et al
Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster.
Leukemia. 2017 Apr 27. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

ROSENQUIST R, Ghia P, Hadzidimitriou A, Sutton LA, et al
Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: Updated eric recommendations.
Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

MAEKAWA T, Osawa Y, Izumi T, Nagao S, et al
Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.
Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

KONGTIM P, Adekola K, Milton DR, Ramlal R, et al
Donor type, in addition to transplantation in chronic phase and myeloablative conditioning, influence transplant survival for patients with advanced chronic myeloid leukemia in the era of tyrosine kinase inhibitors.
Leukemia. 2017 Apr 12. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

HAN SH, Kim SH, Kim HJ, Lee Y, et al
Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia.
Leukemia. 2017 Apr 11. doi: 10.1038/leu.2017.
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JONES D, Woyach JA, Zhao W, Caruthers S, et al
PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment.
Leukemia. 2017 Apr 3. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

SILVA P, Neumann M, Schroeder MP, Vosberg S, et al
Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape.
Leukemia. 2017 Apr 3. doi: 10.1038/leu.2017.
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HEATH EM, Chan SM, Minden MD, Murphy T, et al
Biological and clinical consequences of NPM1 mutations in AML.
Leukemia. 2017;31:798-807.
PubMed Text format Abstract available

VALENT P, Sotlar K, Blatt K, Hartmann K, et al
Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.
Leukemia. 2017;31:788-797.
PubMed Text format Abstract available

SCHUTZ C, Inselmann S, Sausslele S, Dietz CT, et al
Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML.
Leukemia. 2017;31:829-836.
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March 2017

HEROLD S, Kuhn M, Bonin MV, Stange T, et al
Donor cell leukemia-Evidence for multiple pre-leukemic clones and parallel long term clonal evolution in donor and recipient.
Leukemia. 2017 Mar 28. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

ANADON C, van Tetering G, Ferreira HJ, Moutinho C, et al
Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia.
Leukemia. 2017 Mar 27. doi: 10.1038/leu.2017.
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COSSON A, Chapiro E, Bougacha N, Lambert J, et al
Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: Analysis of the central role of XPO1.
Leukemia. 2017 Mar 27. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

MONTALBAN-BRAVO G, Huang X, Naqvi K, Jabbour E, et al
A clinical trial for patients with acute myeloid leukemia or myelodysplastic syndromes not eligible for standard clinical trials.
Leukemia. 2017 Mar 24. doi: 10.1038/leu.2017.
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WALKER CJ, Eisfeld AK, Genutis LK, Bainazar M, et al
No evidence for microsatellite instability in acute myeloid leukemia.
Leukemia. 2017 Mar 24. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

KAYSER S, Krzykalla J, Elliott MA, Norsworthy K, et al
Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide.
Leukemia. 2017 Mar 21. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

ZHOU H, Mak PY, Mu H, Mak DH, et al
Combined inhibition of beta-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo.
Leukemia. 2017 Mar 21. doi: 10.1038/leu.2017.
PubMed Text format Abstract available

EISFELD AK, Mrozek K, Kohlschmidt J, Nicolet D, et al
The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.
Leukemia. 2017 Mar 21. doi: 10.1038/leu.2017.
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POZZO F, Bittolo T, Vendramini E, Bomben R, et al
NOTCH1 mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin-1 and ribosome associated components.
Leukemia. 2017 Mar 21. doi: 10.1038/leu.2017.
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KOEFFLER HP, Leong G
Preleukemia: one name, many meanings.
Leukemia. 2017;31:534-542.
PubMed Text format Abstract available

SAENZ DT, Fiskus W, Manshouri T, Rajapakshe K, et al
BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.
Leukemia. 2017;31:678-687.
PubMed Text format Abstract available

QAZILBASH MH, Wieder E, Thall PF, Wang X, et al
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Leukemia. 2017;31:697-704.
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STRUSKI S, Lagarde S, Bories P, Puiseux C, et al
NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.
Leukemia. 2017;31:565-572.
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STENGEL A, Kern W, Haferlach T, Meggendorfer M, et al
The impact of TP53 mutations and TP53 deletions on survival varies between AML, ALL, MDS and CLL: an analysis of 3307 cases.
Leukemia. 2017;31:705-711.
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MCCRACKEN AN, McMonigle RJ, Tessier J, Fransson R, et al
Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation.
Leukemia. 2017;31:669-677.
PubMed Text format Abstract available

EDELMANN J, Tausch E, Landau DA, Robrecht S, et al
Frequent evolution of copy number alterations in CLL following first-line treatment with FC(R) is enriched with TP53 alterations: results from the CLL8 trial.
Leukemia. 2017;31:734-738.
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February 2017

MEDEIROS BC, Fathi AT, DiNardo CD, Pollyea DA, et al
Isocitrate dehydrogenase mutations in myeloid malignancies.
Leukemia. 2017;31:272-281.
PubMed Text format Abstract available

BURNETT AK, Russell NH, Hills RK, Kell J, et al
A comparison of clofarabine with ara-C, each in combination with daunorubicin as induction treatment in older patients with acute myeloid leukaemia.
Leukemia. 2017;31:310-317.
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