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  Liver Diseases

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Articles published in Am J Pathol

Retrieve available abstracts of 68 articles:
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Single Articles


    February 2026
  1. HRNCIR HR, Goodloe B, Bombin S, Sun SJ, et al
    Quantitative 3D Imaging of Mouse and Human Intrahepatic Bile Ducts in Homeostasis and Liver Injury.
    Am J Pathol. 2026;196:445-459.
    PubMed     Abstract available


    January 2026
  2. YUQUIMPO K, Averilla J, Li Z, Ghosh P, et al
    Liver Macrophage Changes during Early Adaptation to Alcohol Exposure.
    Am J Pathol. 2026;196:272-287.
    PubMed     Abstract available


  3. ZOU H, Wang S, Huang C, Dooley S, et al
    Transforming Growth Factor-beta Signaling in Alcohol-Associated Liver Disease: A Multicellular Perspective.
    Am J Pathol. 2026;196:50-67.
    PubMed     Abstract available


  4. XIAO P, Yang S, Bi S, Hao Y, et al
    Aldehyde Dehydrogenase 2 Deficiency Impairs Liver Progenitor Cell Proliferation in Alcohol-Fed Mice.
    Am J Pathol. 2026;196:256-271.
    PubMed     Abstract available


  5. TERRY D, Robinson BS
    The Sugar-Coated Truth of Alcohol-Associated Liver Disease: Galectins as Multifaceted Regulators of Alcohol-Induced Liver Injury.
    Am J Pathol. 2026;196:161-171.
    PubMed     Abstract available


  6. ZHANG M, Ji J, Song J, An C, et al
    Current Therapeutic Targets for Alcohol-Associated Liver Disease.
    Am J Pathol. 2026;196:121-135.
    PubMed     Abstract available


  7. GRIPSHOVER TC, Treves RS, Hardesty JE
    Identification of Preclinical Biomarkers of Metabolic Dysfunction-Associated Steatotic Liver Disease versus Metabolic Dysfunction and Alcohol-Associated Liver Disease and the Impact of Diet.
    Am J Pathol. 2026;196:241-255.
    PubMed     Abstract available


  8. HARBERTS A, Schnabl B
    Microbiota in Alcohol-Associated Organ Damage.
    Am J Pathol. 2026;196:104-120.
    PubMed     Abstract available


  9. CHO JH, Kim HG, Huang M, Wang S, et al
    The Patatin-Like Phospholipase Domain-Containing 3 148M Variant Exacerbates Alcohol-Induced Liver Injury and Tumorigenesis in Mice.
    Am J Pathol. 2026;196:209-222.
    PubMed     Abstract available


  10. YAN S, Yin XM
    Cholestasis in Alcohol-Associated Liver Disease.
    Am J Pathol. 2026;196:35-49.
    PubMed     Abstract available


  11. FU L, Yokus B, Gao B, Pacher P, et al
    An Update on IL-22 Therapies in Alcohol-Associated Liver Disease and Beyond.
    Am J Pathol. 2026;196:136-150.
    PubMed     Abstract available


  12. CAO P, Chao X, Ni HM, Ding WX, et al
    An Update on Animal Models of Alcohol-Associated Liver Disease.
    Am J Pathol. 2026;196:4-19.
    PubMed     Abstract available


    November 2025
  13. WANG Z, Sun X, Chen Z, Yu J, et al
    Nonalcoholic Steatohepatitis Exacerbates Inflammatory Bone Destruction and Macrophage NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Ligature-Induced Periodontitis.
    Am J Pathol. 2025 Nov 7:S0002-9440(25)00410-9. doi: 10.1016/j.ajpath.2025.
    PubMed     Abstract available


  14. GASPARI C, Beaupere C, Richard S, Peixoto E, et al
    Loss of aquaporin-1 in tumor cells fosters intrahepatic cholangiocarcinoma progression.
    Am J Pathol. 2025 Nov 6:S0002-9440(25)00406-7. doi: 10.1016/j.ajpath.2025.
    PubMed     Abstract available


    October 2025
  15. CACERES A, Shibata NM, Davalos-Gutierrez CD, Sarode GV, et al
    Inactivation of Atp7b copper transporter in intestinal epithelial cells is associated with altered lipid processing and cell growth machinery independent from hepatic copper accumulation and severity of liver histology.
    Am J Pathol. 2025 Oct 16:S0002-9440(25)00379.
    PubMed     Abstract available


  16. LI N, Wu S, Li X, Yan M, et al
    Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis.
    Am J Pathol. 2025;195:1822-1838.
    PubMed     Abstract available


    September 2025
  17. JAIN S, Mukherjee R, Williams G, Liu JJ, et al
    Hepatocyte-specific MET deletion exacerbates acetaminophen-induced hepatotoxicity in mice.
    Am J Pathol. 2025 Sep 30:S0002-9440(25)00367.
    PubMed     Abstract available


  18. WANG Z, Xu Q, Wang M, Xiao Q, et al
    Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients and Mice with Wilson Disease.
    Am J Pathol. 2025;195:1600-1618.
    PubMed     Abstract available


    August 2025
  19. OMAR DY, Willoughby MM, Mostafa N, Otakhor K, et al
    Lipid Droplet Dynamics in Alcoholic Steatohepatitis.
    Am J Pathol. 2025 Aug 26:S0002-9440(25)00299.
    PubMed     Abstract available


    July 2025
  20. LIU W, Lin YT, Han DG, Shi AC, et al
    Enhancement of TNFalpha-mediated hepatic apoptosis and liver injury by Hepatitis B virus surface antigen.
    Am J Pathol. 2025 Jul 24:S0002-9440(25)00247.
    PubMed     Abstract available


  21. LIU J, Li J, Li Y, Wei M, et al
    Transcription Factor YY2 Inhibits Tumor Cell Glutamine Catabolism by Regulating GLS1 RNA Splicing Isoform GAC.
    Am J Pathol. 2025;195:1340-1357.
    PubMed     Abstract available


    June 2025
  22. ZHONG H, Liu C, Huang Z, Tan P, et al
    Crosstalk between Hepatic Stellate Cells and Hepatic Macrophages in Metabolic Dysfunction-Associated Steatohepatitis.
    Am J Pathol. 2025;195:1040-1056.
    PubMed     Abstract available


    May 2025
  23. XUE Y, Tian T, Ottallah M, Mannan M, et al
    Alcohol-Associated Hepatocarcinogenesis: Wnt/beta-Catenin in Action.
    Am J Pathol. 2025 May 9:S0002-9440(25)00156-7. doi: 10.1016/j.ajpath.2025.
    PubMed     Abstract available


  24. KEEGAN A, Malamal G, Lee Y, Korolowicz K, et al
    Multimodal Diagnostic Imaging of Metabolic Dysfunction-Associated Steatotic Liver Disease: Noninvasive Analyses by Photoacoustic Ultrasound and Magnetic Resonance Imaging.
    Am J Pathol. 2025;195:875-890.
    PubMed     Abstract available


    April 2025
  25. RODEMANN MM, Dreschmann V, Dorner E, Sommer A, et al
    Identification of a growth-promoting gene cluster in the region 2q24 as a driver of tumorigenesis in childhood hepatoblastoma.
    Am J Pathol. 2025 Apr 30:S0002-9440(25)00147.
    PubMed     Abstract available


  26. XU L, Zhao Y, Yang Y, Qi E, et al
    Constitutive hepatic mTORC1 activation aggravates alcohol-induced liver injury via endoplasmic reticulum stress-mediated ferroptosis.
    Am J Pathol. 2025 Apr 7:S0002-9440(25)00106-3. doi: 10.1016/j.ajpath.2025.
    PubMed     Abstract available


    March 2025
  27. WANG Z, Liang G, Peng J, Gu Y, et al
    Sirtuin 7 Promotes Alcohol-Associated Liver Injury via Modulating Myeloid Cell Chemokine (C-C Motif) Ligand 2 Secretion through the NF-kappaB Signaling Pathway.
    Am J Pathol. 2025;195:575-588.
    PubMed     Abstract available


  28. CASILLAS-RAMIREZ A, Maroto-Serrat C, Sanus F, Mico-Carnero M, et al
    Regulation of Adiponectin and Resistin in Liver Transplantation Protects Grafts from Extended-Criteria Donors.
    Am J Pathol. 2025;195:494-527.
    PubMed     Abstract available


    February 2025
  29. KHA M, Magnusson Y, Johansson I, Altiparmak G, et al
    Injured Proximal Tubular Epithelial Cells Lose Hepatocyte Nuclear Factor 4alpha Expression Crucial for Brush Border Formation and Transport.
    Am J Pathol. 2025 Feb 13:S0002-9440(25)00047.
    PubMed     Abstract available


    January 2025
  30. CHEN K, Wang H, Ma B, Knapp J, et al
    Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis.
    Am J Pathol. 2025 Jan 29:S0002-9440(25)00037.
    PubMed     Abstract available


  31. ISHIHARA N, Koma YI, Omori M, Komatsu S, et al
    CCL2/CCR2/Erk Signal Induced through Cancer Cell-Macrophage Interaction Contributes to Hepatocellular Carcinoma Progression.
    Am J Pathol. 2025 Jan 3:S0002-9440(24)00480-2. doi: 10.1016/j.ajpath.2024.
    PubMed     Abstract available


    December 2024
  32. HUANG X, Zheng S, Li S, Huang Y, et al
    Machine learning-based pathomics model predicts ANGPT2 expression and prognosis in hepatocellular carcinoma.
    Am J Pathol. 2024 Dec 31:S0002-9440(24)00478.
    PubMed     Abstract available


  33. ZUO R, Wang M, Wang YT, ShenTu Y, et al
    Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice.
    Am J Pathol. 2024 Dec 20:S0002-9440(24)00444.
    PubMed     Abstract available


    November 2024
  34. TUFFS C, Dupovac M, Richter K, Holten S, et al
    Genetic Loss of HIF-Prolyl-Hydroxylase (PHD) 1, but not pharmacological Inhibition, mitigates hepatic fibrosis.
    Am J Pathol. 2024 Nov 18:S0002-9440(24)00411.
    PubMed     Abstract available


  35. ZHANG H, Lei S, Zhuo H, Xu Y, et al
    TRIM24 Up-Regulates ORM2 to Alleviate Abnormal Lipid Metabolism, Inflammation, and Oxidative Stress in Mice with Obstructive Sleep Apnea Syndrome and Metabolic Dysfunction-Associated Steatotic Liver Disease.
    Am J Pathol. 2024;194:2091-2105.
    PubMed     Abstract available


  36. LI Z, Sun T, He Z, Li Z, et al
    Intestinal Dysbacteriosis Contributes to Persistent Cognitive Impairment after Resolution of Acute Liver Failure.
    Am J Pathol. 2024;194:2076-2090.
    PubMed     Abstract available


    October 2024
  37. HUANG CC, Wang CH, Yeh HY, Tsai HC, et al
    Chronic Peroxisome Proliferator-Activated Receptor alpha/gamma and Cannabinoid Receptor 2 Agonist Treatments Attenuated Visceral Adipose Tissue (VAT)-Derived Extracellular Vesicle-Related VAT and Intestinal Abnormalities in Nonalcoholic Steatohepatitis
    Am J Pathol. 2024 Oct 26:S0002-9440(24)00398.
    PubMed     Abstract available


    September 2024
  38. GUEST RV, Goeppert B, Nault JC, Sia D, et al
    Morphomolecular pathology and Genomic Insights into the Cells of Origin of Cholangiocarcinoma and combined Hepatocellular-Cholangiocarcinoma.
    Am J Pathol. 2024 Sep 26:S0002-9440(24)00357.
    PubMed     Abstract available


  39. CHEON I, Kim M, Kim KH, Ko S, et al
    Hepatic Nuclear Receptors in Cholestasis-to-Cholangiocarcinoma Pathology.
    Am J Pathol. 2024 Sep 24:S0002-9440(24)00358.
    PubMed     Abstract available


  40. LI J, Ding X, Yan W, Liu K, et al
    Tumor-derived Immunoglobulin-like transcript 4 promotes postoperative relapse via inducing vasculogenic mimicry through MAPK/ERK signaling in hepatocellular carcinoma.
    Am J Pathol. 2024 Sep 2:S0002-9440(24)00329-8. doi: 10.1016/j.ajpath.2024.
    PubMed     Abstract available


    August 2024
  41. JIANG L, Xu QY, Zhou YC, Xu J, et al
    Spatial transcriptomics reveals the transcriptomic signatures in a mouse model of pediatric metabolic dysfunction-associated steatohepatitis.
    Am J Pathol. 2024 Aug 31:S0002-9440(24)00327.
    PubMed     Abstract available


  42. LEYA M, Jeong H, Yang D, Bao THTN, et al
    Hepatocyte-specific casein kinase 1 epsilon ablation ameliorates metabolic dysfunction-associated steatohepatitis by upregulating TRAF3 in mice.
    Am J Pathol. 2024 Aug 21:S0002-9440(24)00299.
    PubMed     Abstract available


  43. AFF? S, Sererols-Vinas L, Garcia-Vicien G, Cadamuro M, et al
    Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma: Insights into Origins, Heterogeneity, Lymphangiogenesis, and Peritoneal Metastasis.
    Am J Pathol. 2024 Aug 6:S0002-9440(24)00279-7. doi: 10.1016/j.ajpath.2024.
    PubMed     Abstract available


  44. PANT K, Gradilone SA
    NAMPT Overexpression Drives Cell Growth in Polycystic Liver Disease through Mitochondrial Metabolism Regulation.
    Am J Pathol. 2024;194:1528-1537.
    PubMed     Abstract available


    July 2024
  45. YANG L, Pham K, Xi Y, Jiang S, et al
    Acyl-CoA Synthetase Medium Chain Family Member 5 Mediated Fatty Acid Metabolism Dysregulation Promotes the Progression of Hepatocellular Carcinoma.
    Am J Pathol. 2024 Jul 26:S0002-9440(24)00244.
    PubMed     Abstract available


    June 2024
  46. LAURENT-BELLUE A, Sadraoui A, Claude L, Calderaro J, et al
    Deep learning classification and quantification of pejorative and non-pejorative architectures in resected hepatocellular carcinoma from digital histopathological images.
    Am J Pathol. 2024 Jun 13:S0002-9440(24)00206.
    PubMed     Abstract available


  47. ZHANG Y, Liu Y, Huo W, He L, et al
    The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases.
    Am J Pathol. 2024;194:879-893.
    PubMed     Abstract available


    May 2024
  48. MARTUCCI NJ, Stoops J, Bowen W, Orr A, et al
    A novel role for the phosphatidylinositol-4,5-bisphosphate 3-kinase delta isoform in hepatocellular proliferation.
    Am J Pathol. 2024 May 3:S0002-9440(24)00168-8. doi: 10.1016/j.ajpath.2024.
    PubMed     Abstract available


    April 2024
  49. HU J, Xu H, Ma X, Bai M, et al
    Modulating PCGF4 Stability Is an Efficient Metastasis-Regulatory Strategy Used by Distinct Subtypes of Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma.
    Am J Pathol. 2024 Apr 24:S0002-9440(24)00160.
    PubMed     Abstract available


    March 2024
  50. NGO HV, Thanh Le TT, Vu HN, Hoang H, et al
    Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40-CD40L Linkage.
    Am J Pathol. 2024 Mar 26:S0002-9440(24)00117.
    PubMed     Abstract available


  51. YU YP, Liu S, Geller D, Luo JH, et al
    Serum fusion transcripts to assess the risk of hepatocellular carcinoma and the impact of cancer treatment through machine learning.
    Am J Pathol. 2024 Mar 25:S0002-9440(24)00111.
    PubMed     Abstract available


    February 2024
  52. NEWBERRY EP, Molitor EA, Liu A, Chong K, et al
    Impaired hepatic VLDL secretion promotes tumorigenesis and is accelerated with Fabp1 deletion.
    Am J Pathol. 2024 Feb 26:S0002-9440(24)00074.
    PubMed     Abstract available


  53. LIAN V, Hinrichs H, Young M, Faerber A, et al
    Maternal Obesogenic Diet Attenuates Microbiome-Dependent Offspring Weaning Reaction with Worsening of Steatotic Liver Disease.
    Am J Pathol. 2024;194:209-224.
    PubMed     Abstract available


  54. ABUDUYIMITI T, Goto H, Kimura K, Oshima Y, et al
    Diabetes accelerates steatohepatitis in mice: liver pathology and single-cell gene expression signatures.
    Am J Pathol. 2024 Feb 1:S0002-9440(24)00037-3. doi: 10.1016/j.ajpath.2024.
    PubMed     Abstract available


    December 2023
  55. TAN PK, Ostertag T, Rosenthal SB, Chilin-Fuentes D, et al
    Role of Hepatic Stellate and Liver Sinusoidal Endothelial Cells in a Human Primary Cell Three-Dimensional Model of Nonalcoholic Steatohepatitis.
    Am J Pathol. 2023 Dec 28:S0002-9440(23)00484.
    PubMed     Abstract available


  56. WEN T, Xie J, Ma L, Hao Z, et al
    Vitamin D receptor activation reduces hepatic inflammation via enhancing macrophage autophagy in cholestatic mice.
    Am J Pathol. 2023 Dec 15:S0002-9440(23)00462.
    PubMed     Abstract available


  57. JIANG C, Saiki Y, Hirota S, Iwata K, et al
    Ablation of Dual-Specificity Phosphatase 6 Protects against Nonalcoholic Fatty Liver Disease via Cytochrome P450 4A and Mitogen-Activated Protein Kinase.
    Am J Pathol. 2023;193:1988-2000.
    PubMed     Abstract available


  58. VENKATESAN N, Doskey LC, Malhi H
    The Role of Endoplasmic Reticulum in Lipotoxicity during Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Pathogenesis.
    Am J Pathol. 2023;193:1887-1899.
    PubMed     Abstract available


    November 2023
  59. WARNER JB, Hardesty JE, Song YL, Floyd AT, et al
    Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease.
    Am J Pathol. 2023 Nov 2:S0002-9440(23)00410-8. doi: 10.1016/j.ajpath.2023.
    PubMed     Abstract available


    October 2023
  60. FENG R, Tong C, Lin T, Liu H, et al
    Insulin determines TGF-beta effects on HNF4alpha transcription in hepatocytes.
    Am J Pathol. 2023 Oct 9:S0002-9440(23)00365-6. doi: 10.1016/j.ajpath.2023.
    PubMed     Abstract available


  61. MAIERS JL, Chakraborty S
    The Cellular, Molecular, and Pathologic Consequences of Stress on the Liver.
    Am J Pathol. 2023;193:1353-1354.
    PubMed    


  62. ISMAIL A, Kennedy L, Francis H
    Sex-Dependent Differences in Cholestasis: Why Estrogen Signaling May Be a Key Pathophysiological Driver.
    Am J Pathol. 2023;193:1355-1362.
    PubMed     Abstract available


  63. BANERJEE P, Gaddam N, Chandler V, Chakraborty S, et al
    Oxidative Stress-Induced Liver Damage and Remodeling of the Liver Vasculature.
    Am J Pathol. 2023;193:1400-1414.
    PubMed     Abstract available


  64. JACKSON KG, Way GW, Zeng J, Lipp MK, et al
    The Dynamic Role of Endoplasmic Reticulum Stress in Chronic Liver Disease.
    Am J Pathol. 2023;193:1389-1399.
    PubMed     Abstract available


  65. ALI N, Ferrao K, Mehta KJ
    Liver Iron Loading in Alcohol-Associated Liver Disease.
    Am J Pathol. 2023;193:1427-1439.
    PubMed     Abstract available


    September 2023
  66. FITZGERALD H, Bonin JL, Khan S, Eid M, et al
    Resolvin D2-GPR18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.
    Am J Pathol. 2023 Sep 15:S0002-9440(23)00322.
    PubMed     Abstract available


  67. TANAKA M, Jeong J, Thomas C, Zhang X, et al
    The sympathetic nervous system promotes hepatic lymphangiogenesis, which is protective against liver fibrosis.
    Am J Pathol. 2023 Sep 4:S0002-9440(23)00308-5. doi: 10.1016/j.ajpath.2023.
    PubMed     Abstract available


  68. CHAN KK, Au KY, Suen LH, Leung B, et al
    SORTILIN-DRIVEN CANCER SECRETOME ENHANCES TUMORIGENIC PROPERTIES OF HEPATOCELLULAR CARCINOMA VIA DE NOVO LIPOGENESIS.
    Am J Pathol. 2023 Sep 4:S0002-9440(23)00310-3. doi: 10.1016/j.ajpath.2023.
    PubMed     Abstract available


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