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  Lung Cancer

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Articles published in Cancer Res

Retrieve available abstracts of 69 articles:
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Single Articles


    June 2025
  1. WANG Y, Meraz IM, Qudratullah M, Kotagiri S, et al
    Mutation of SMARCA4 Induces Cancer Cell-Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy.
    Cancer Res. 2025;85:1997-2013.
    PubMed     Abstract available


    May 2025
  2. TONG X, Lin G, Ji H
    "Dr. Jekyll and Mr. Hyde": AT2 Cells in Lung Regeneration and Tumor Development.
    Cancer Res. 2025;85:1753-1754.
    PubMed     Abstract available


  3. WANG K, Li J, Zhang H, Ma H, et al
    Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.
    Cancer Res. 2025 May 14. doi: 10.1158/0008-5472.CAN-24-3525.
    PubMed     Abstract available


  4. QU T, Song L, Xu J, Lu X, et al
    MYLK-AS1 Enhances Glutamine Metabolism to Promote EGFR Inhibitor Resistance in Non-Small Cell Lung Cancer.
    Cancer Res. 2025 May 14. doi: 10.1158/0008-5472.CAN-23-3748.
    PubMed     Abstract available


  5. THOMAS-JARDIN S, Suresh S, Arce A, Novaresi N, et al
    The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer.
    Cancer Res. 2025 May 6. doi: 10.1158/0008-5472.CAN-24-3844.
    PubMed     Abstract available


  6. PAPARGYRIOU A, Reichert M
    The Biology in the Pattern: Metastatic Organotropism and Clinical Outcome Depend on DNA Damage Response and Immune Interactions in Pancreatic Cancer.
    Cancer Res. 2025;85:1571-1573.
    PubMed     Abstract available


  7. HAN J, Du J, Li X, Zhou Q, et al
    The Glycosyltransferase XYLT1 Activates NF-kappaB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma.
    Cancer Res. 2025;85:1628-1643.
    PubMed     Abstract available


    April 2025
  8. CAI L, Wu F, Zhou Q, Gao Y, et al
    The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models.
    Cancer Res. 2025 Apr 29:OF1-OF15. doi: 10.1158/0008-5472.CAN-24-1607.
    PubMed     Abstract available


  9. LIU C, Du H, Yu G, Qi J, et al
    Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression.
    Cancer Res. 2025 Apr 9. doi: 10.1158/0008-5472.CAN-24-3481.
    PubMed     Abstract available


  10. EIGENBROOD J, Wong N, Mallory P, Pereira JS, et al
    Spatial Profiling Identifies Regionally Distinct Microenvironments and Targetable Immunosuppressive Mechanisms in Pediatric Osteosarcoma Pulmonary Metastases.
    Cancer Res. 2025 Apr 2. doi: 10.1158/0008-5472.CAN-24-3723.
    PubMed     Abstract available


    March 2025
  11. LEE TR, Ahn JM, Lee J, Kim D, et al
    Integrating Plasma Cell-Free DNA Fragment End Motif and Size with Genomic Features Enables Lung Cancer Detection.
    Cancer Res. 2025 Mar 26:OF1-OF12. doi: 10.1158/0008-5472.CAN-24-1517.
    PubMed     Abstract available


  12. SOS ML, Koker M, Weir BA, Heynck S, et al
    Editor's Note: PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR.
    Cancer Res. 2025;85:1003.
    PubMed    


    February 2025
  13. BADO IL
    Deterministic Role of FOXF2 in Organ-Specific Macrometastasis Transition.
    Cancer Res. 2025;85:639-641.
    PubMed     Abstract available


  14. CHEN YC, Hsu CL, Wang HM, Wu SG, et al
    Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers.
    Cancer Res. 2025;85:602-617.
    PubMed     Abstract available


  15. ZHANG Y, Song X, Feng Y, Qian Y, et al
    The circRNA cEMSY Induces Immunogenic Cell Death and Boosts Immunotherapy Efficacy in Lung Adenocarcinoma.
    Cancer Res. 2025;85:497-514.
    PubMed     Abstract available


    January 2025
  16. DALEY BR, Sealover NE, Finniff BA, Hughes JM, et al
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma.
    Cancer Res. 2025;85:118-133.
    PubMed     Abstract available


    December 2024
  17. CHEN SY, He PL, Lu LY, Lin MC, et al
    ST6GAL1-Mediated Sialylation of PECAM-1 Promotes a Transcellular Diapedesis-Like Process that Directs Lung Tropism of Metastatic Breast Cancer.
    Cancer Res. 2024 Dec 30. doi: 10.1158/0008-5472.CAN-24-1550.
    PubMed     Abstract available


  18. SAAL J, Klumper N, Holzel M
    C-Reactive Protein Facilitates Premetastatic Niche Formation in the Lungs.
    Cancer Res. 2024;84:4121-4123.
    PubMed     Abstract available


  19. FENG JR, Li X, Han C, Chang Y, et al
    C-Reactive Protein Induces Immunosuppression by Activating FcgammaR2B in Pulmonary Macrophages to Promote Lung Metastasis.
    Cancer Res. 2024;84:4184-4198.
    PubMed     Abstract available


    November 2024
  20. JIANG WJ, Zhou TH, Huang HJ, Li LS, et al
    Breast Cancer Subtype-Specific Organotropism is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery.
    Cancer Res. 2024 Nov 26. doi: 10.1158/0008-5472.CAN-24-0479.
    PubMed     Abstract available


  21. WANG S, Lai JC, Li Y, Tang C, et al
    Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR Mutant Non-Small Cell Lung Cancer.
    Cancer Res. 2024 Nov 8. doi: 10.1158/0008-5472.CAN-24-1817.
    PubMed     Abstract available


    October 2024
  22. XU H, Yue M, Zhou R, Wang P, et al
    A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8+ T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis.
    Cancer Res. 2024;84:3173-3188.
    PubMed     Abstract available


    September 2024
  23. MAY L, Hu B, Jerajani P, Jagdeesh A, et al
    The Innate Immune System and TRAIL-BCL-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females.
    Cancer Res. 2024 Sep 23. doi: 10.1158/0008-5472.CAN-24-0585.
    PubMed     Abstract available


  24. SMITH MR, Dixon CB, Wang Y, Liu Y, et al
    Targeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-type Non-Small Cell Lung Cancer.
    Cancer Res. 2024 Sep 9. doi: 10.1158/0008-5472.CAN-24-0658.
    PubMed     Abstract available


  25. CONNER SJ, Borges HB, Guarin JR, Gerton TJ, et al
    Obesity Induces Temporally Regulated Alterations in the Extracellular Matrix That Drive Breast Tumor Invasion and Metastasis.
    Cancer Res. 2024;84:2761-2775.
    PubMed     Abstract available


    August 2024
  26. KOO J, Seong CS, Parker RE, Herrera A, et al
    Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer.
    Cancer Res. 2024 Aug 29. doi: 10.1158/0008-5472.CAN-23-2631.
    PubMed     Abstract available


  27. LIN W, Wang N, Wu S, Diao M, et al
    NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non-Small Cell Lung Carcinoma.
    Cancer Res. 2024 Aug 19. doi: 10.1158/0008-5472.CAN-24-0249.
    PubMed     Abstract available


  28. ZHANG C, Zhou L, Zhang M, Du Y, et al
    H3K18 Lactylation Potentiates Immune Escape of Non-Small Cell Lung Cancer.
    Cancer Res. 2024 Aug 13. doi: 10.1158/0008-5472.CAN-23-3513.
    PubMed     Abstract available


  29. FU M, Gao Q, Xiao M, Li RF, et al
    Extracellular Vesicles Containing circMYBL1 Induce CD44 in Adenoid Cystic Carcinoma Cells and Pulmonary Endothelial Cells to Promote Lung Metastasis.
    Cancer Res. 2024;84:2484-2500.
    PubMed     Abstract available


    July 2024
  30. WANG X, Qu Y, Xu Q, Jiang Z, et al
    NQO1 Triggers Neutrophil Recruitment and NET formation to Drive Lung Metastasis of Invasive Breast Cancer.
    Cancer Res. 2024 Jul 29. doi: 10.1158/0008-5472.CAN-24-0291.
    PubMed     Abstract available


  31. LI J, Luo L, He J, Yu J, et al
    A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors.
    Cancer Res. 2024;84:2352-2363.
    PubMed     Abstract available


    June 2024
  32. OATMAN N, Gawali MV, Congrove S, Caceres R, et al
    A multimodal drug-diet-immunotherapy combination restrains melanoma progression and metastasis.
    Cancer Res. 2024 Jun 17. doi: 10.1158/0008-5472.CAN-23-1635.
    PubMed     Abstract available


  33. HUANG CY, Jiang N, Shen M, Lai GG, et al
    Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations.
    Cancer Res. 2024;84:2009-2020.
    PubMed     Abstract available


  34. HERZOG C, Jones A, Evans I, Raut JR, et al
    Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis.
    Cancer Res. 2024;84:1898-1914.
    PubMed     Abstract available


    May 2024
  35. RAINERO E
    Overcoming Nutrient Stress: Integrin alphavbeta3-Driven Metabolic Adaptation Supports Tumor Initiation.
    Cancer Res. 2024;84:1543-1545.
    PubMed     Abstract available


  36. PARK SJ, Ju S, Goh SH, Yoon BH, et al
    Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations.
    Cancer Res. 2024;84:1491-1503.
    PubMed     Abstract available


  37. XIANG H, Pan Y, Sze MA, Wlodarska M, et al
    Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma.
    Cancer Res. 2024;84:1410-1425.
    PubMed     Abstract available


    April 2024
  38. BOUMELHA J, de Castro A, Bah N, Cha H, et al
    CRISPR-Cas9 screening identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer.
    Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2627.
    PubMed     Abstract available


  39. RUMDE PH, Burns TF
    A Path to Persistence after EGFR Inhibition.
    Cancer Res. 2024;84:1188-1190.
    PubMed     Abstract available


  40. PETRONI G, Pillozzi S, Antonuzzo L
    Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy.
    Cancer Res. 2024;84:1199-1209.
    PubMed     Abstract available


  41. LAU A, Blenis J, Burgos-Barragan G
    Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies.
    Cancer Res. 2024;84:1191-1194.
    PubMed     Abstract available


  42. ZHU X, Fu Z, Dutchak K, Arabzadeh A, et al
    Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer.
    Cancer Res. 2024;84:1333-1351.
    PubMed     Abstract available


  43. NAM A, Jain S, Wu C, Campos A, et al
    Integrin alphavbeta3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.
    Cancer Res. 2024 Apr 8:OF1-OF13. doi: 10.1158/0008-5472.CAN-23-2700.
    PubMed     Abstract available


  44. LIU Y, Murazzi I, Fuller AM, Pan H, et al
    Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis.
    Cancer Res. 2024;84:977-993.
    PubMed     Abstract available


  45. XU Y, Deng C, Chen H, Song Y, et al
    Osteosarcoma Cells Secrete CXCL14 That Activates Integrin alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
    Cancer Res. 2024;84:994-1012.
    PubMed     Abstract available


    March 2024
  46. GAI X, Liu Y, Lan X, Chen L, et al
    Oncogenic KRAS induces arginine auxotrophy and confers a therapeutic vulnerability to SLC7A1 inhibition in non-small cell lung cancer.
    Cancer Res. 2024 Mar 19. doi: 10.1158/0008-5472.CAN-23-2095.
    PubMed     Abstract available


  47. WANG H, Zhang Y, Tian Y, Yang W, et al
    DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance.
    Cancer Res. 2024;84:688-702.
    PubMed     Abstract available


    February 2024
  48. HU B, Wiesehofer M, de Miguel FJ, Liu Z, et al
    ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts.
    Cancer Res. 2024 Feb 15. doi: 10.1158/0008-5472.CAN-23-0438.
    PubMed     Abstract available


  49. ALEWINE C
    Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis.
    Cancer Res. 2024;84:513-514.
    PubMed     Abstract available


  50. RIGAMONTI A, Viatore M, Polidori R, Rahal D, et al
    Integrating AI-powered digital pathology and imaging mass cytometry identifies key classifiers of tumor cells, stroma, and immune cells in non-small cell lung cancer.
    Cancer Res. 2024 Feb 5. doi: 10.1158/0008-5472.CAN-23-1698.
    PubMed     Abstract available


    January 2024
  51. MU M, Huang CX, Qu C, Li PL, et al
    Targeting ferroptosis-elicited inflammation suppresses hepatocellular carcinoma metastasis and enhances sorafenib efficacy.
    Cancer Res. 2024 Jan 17. doi: 10.1158/0008-5472.CAN-23-1796.
    PubMed     Abstract available


  52. SAGGESE P, Pandey A, Alcaraz M Jr, Fung E, et al
    Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma.
    Cancer Res. 2024;84:305-327.
    PubMed     Abstract available


    December 2023
  53. NIU X, Martinez L
    Harnessing p53 to Improve Immunotherapy for Lung Cancer Treatment.
    Cancer Res. 2023 Dec 21:OF1-OF2. doi: 10.1158/0008-5472.CAN-23-3929.
    PubMed     Abstract available


  54. DU M, Xin J, Zheng R, Yuan Q, et al
    CYP2A6 activity and cigarette consumption interact in smoking-related lung cancer susceptibility.
    Cancer Res. 2023 Dec 20. doi: 10.1158/0008-5472.CAN-23-0900.
    PubMed     Abstract available


  55. MUKHOPADHYAY S, Huang HY, Lin Z, Ranieri M, et al
    Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.
    Cancer Res. 2023;83:4095-4111.
    PubMed     Abstract available


  56. NIU X, Martinez L
    Harnessing p53 to improve immunotherapy for lung cancer treatment.
    Cancer Res. 2023 Dec 14. doi: 10.1158/0008-5472.CAN-23-3929.
    PubMed     Abstract available


  57. XIA L, Liu JY, Yang MY, Zhang XH, et al
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells.
    Cancer Res. 2023 Dec 14. doi: 10.1158/0008-5472.CAN-23-1632.
    PubMed     Abstract available


  58. MICHAUD DE, Guerriero JL
    Myeloid cells pave the metastatic road in breast cancer.
    Cancer Res. 2023 Dec 6. doi: 10.1158/0008-5472.CAN-23-3803.
    PubMed     Abstract available


    November 2023
  59. KO JH, Lambert KE, Bhattacharya D, Lee MC, et al
    Small cell lung cancer plasticity enables NFIB-independent metastasis.
    Cancer Res. 2023 Nov 14. doi: 10.1158/0008-5472.CAN-23-1079.
    PubMed     Abstract available


  60. PRAHALLAD A, Weiss A, Voshol H, Kerr G, et al
    CRISPR screening identifies mechanisms of resistance to KRASG12C and SHP2 inhibitor combinations in non-small cell lung cancer.
    Cancer Res. 2023 Nov 7. doi: 10.1158/0008-5472.CAN-23-1127.
    PubMed     Abstract available


  61. WEBER MC, Izzo LT, Oliver TG
    Epigenetic Regulators Open the Door to SCLC Plasticity.
    Cancer Res. 2023;83:3495-3497.
    PubMed     Abstract available


  62. COTTON JL, Estrada Diez J, Sagar V, Chen J, et al
    Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance.
    Cancer Res. 2023;83:3611-3623.
    PubMed     Abstract available


    October 2023
  63. HARIPRAKASH JM, Salviato E, La Mastra F, Sebestyen E, et al
    Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer.
    Cancer Res. 2023 Oct 19. doi: 10.1158/0008-5472.CAN-23-1129.
    PubMed     Abstract available


  64. WU J, Subbiah V
    RETooling the RET Inhibitor Pralsetinib for ESR1 Fusion-Positive Breast Cancer and Beyond.
    Cancer Res. 2023;83:3159-3161.
    PubMed     Abstract available


  65. YANAGAWA J, Tran LM, Salehi-Rad R, Lim RJ, et al
    Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma.
    Cancer Res. 2023;83:3305-3319.
    PubMed     Abstract available


  66. NAMBIAR DK, Viswanathan V, Cao H, Zhang W, et al
    Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment.
    Cancer Res. 2023;83:3205-3219.
    PubMed     Abstract available


    August 2023
  67. COHEN N, Mundhe D, Deasy SK, Adler O, et al
    Breast cancer-secreted factors promote lung metastasis by signaling systemically to induce a fibrotic pre-metastatic niche.
    Cancer Res. 2023 Aug 7:CAN-22-3707. doi: 10.1158/0008-5472.CAN-22-3707.
    PubMed     Abstract available


  68. MATHUR D, Liao C, Lin W, La Ferlita A, et al
    The ratio of key metabolic transcripts is a predictive biomarker of breast cancer metastasis to the lung.
    Cancer Res. 2023 Aug 1:CAN-23-0153. doi: 10.1158/0008-5472.CAN-23-0153.
    PubMed     Abstract available


    July 2023
  69. KA NL, Park MK, Kim SS, Jeon Y, et al
    NR1D1 stimulates antitumor immune responses in breast cancer by activating cGAS-STING signaling.
    Cancer Res. 2023 Jul 3:CAN-23-0329. doi: 10.1158/0008-5472.CAN-23-0329.
    PubMed     Abstract available


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