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Articles published in Clin Cancer Res

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    November 2023
  1. MURRAY JC, Sivapalan L, Hummelink K, Balan A, et al
    Elucidating the heterogeneity of immunotherapy response and immune-related toxicities by longitudinal ctDNA and immune cell compartment tracking in lung cancer.
    Clin Cancer Res. 2023 Nov 8. doi: 10.1158/1078-0432.CCR-23-1469.
    PubMed     Abstract available

    October 2023
  2. HERBST RS, Blanke CD, Sigal EV
    Novel Approach to Accelerate Lung Cancer Research: LungMap and the Potential of Public-Private Partnerships.
    Clin Cancer Res. 2023 Oct 30. doi: 10.1158/1078-0432.CCR-23-2690.
    PubMed     Abstract available

  3. PAZ-ARES L, Garassino MC, Chen Y, Reinmuth N, et al
    Durvalumab +/- tremelimumab + platinum-etoposide in extensive-stage small-cell lung cancer (CASPIAN): outcomes by PD-L1 expression and tissue tumor mutational burden.
    Clin Cancer Res. 2023 Oct 6. doi: 10.1158/1078-0432.CCR-23-1689.
    PubMed     Abstract available

    September 2023
  4. BESSEDE A, Peyraud F, Le Moulec S, Cousin S, et al
    Upregulation of Indoleamine 2,3-dioxygenase 1 in tumor cells and tertiary lymphoid structures is a hallmark of inflamed non-small cell lung cancer.
    Clin Cancer Res. 2023 Sep 26. doi: 10.1158/1078-0432.CCR-23-1928.
    PubMed     Abstract available

  5. DIMOU A
    Time to Think About Human Leukocyte Antigen-Based Diagnostics in Lung Cancer?
    Clin Cancer Res. 2023 Sep 26. doi: 10.1158/1078-0432.CCR-23-2152.
    PubMed     Abstract available

  6. SOLTA A, Boettiger K, Kovacs I, Lang C, et al
    Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair.
    Clin Cancer Res. 2023 Sep 19. doi: 10.1158/1078-0432.CCR-23-1795.
    PubMed     Abstract available

  7. CANTOR DJ, Aggarwal C
    Targeting KRAS-Mutated NSCLC: Novel TKIs and Beyond.
    Clin Cancer Res. 2023;29:3563-3565.
    PubMed     Abstract available

  8. DUKE ES, Bradford D, Marcovitz M, Amatya AK, et al
    FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
    Clin Cancer Res. 2023;29:3573-3578.
    PubMed     Abstract available

  9. ABEL ML, Takahashi N, Peer C, Redon CE, et al
    Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial.
    Clin Cancer Res. 2023;29:3603-3611.
    PubMed     Abstract available

  10. PELLINI B, Madison RW, Childress M, Miller ST, et al
    Circulating Tumor DNA Monitoring on Chemo-immunotherapy for Risk Stratification in Advanced Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2023 Sep 13. doi: 10.1158/1078-0432.CCR-23-1578.
    PubMed     Abstract available

    August 2023
  11. ZHOU X, Zhou L, Yao Z, Huang M, et al
    Safety and Tolerability of Low-Dose Radiation and Stereotactic Body Radiotherapy + Sintilimab for Treatment-Naive Stage IV PD-L1+ Non-Small-Cell Lung Cancer Patients.
    Clin Cancer Res. 2023 Aug 15:CCR-23-0315. doi: 10.1158/1078-0432.CCR-23-0315.
    PubMed     Abstract available

  12. KREBS MG, Popat S
    RETaliation-Tackling Rare Resistance Alterations to Osimertinib.
    Clin Cancer Res. 2023;29:2951-2953.
    PubMed     Abstract available

  13. ROTOW J, Patel JD, Hanley MP, Yu H, et al
    Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers.
    Clin Cancer Res. 2023;29:2979-2987.
    PubMed     Abstract available

  14. MATHIEU LN, Larkins E, Sinha AK, Mishra-Kalyani PS, et al
    FDA Approval Summary: Atezolizumab as Adjuvant Treatment following Surgical Resection and Platinum-Based Chemotherapy for Stage II to IIIA NSCLC.
    Clin Cancer Res. 2023;29:2973-2978.
    PubMed     Abstract available

  15. VALENCIA K, Montuenga LM, Calvo A
    Estrogen receptor and immune checkpoint inhibitors: new partners in lung cancer?
    Clin Cancer Res. 2023 Aug 7:CCR-23-1736. doi: 10.1158/1078-0432.CCR-23-1736.
    PubMed     Abstract available

    July 2023
  16. JIANG T, Jin Q, Wang J, Wu F, et al
    HLA-I evolutionary divergence confers response to PD-1 blockade plus chemotherapy in untreated advanced non-small-cell lung cancer.
    Clin Cancer Res. 2023 Jul 14:CCR-23-0604. doi: 10.1158/1078-0432.CCR-23-0604.
    PubMed     Abstract available

  17. CORTELLINI A, D'Alessio A, Cleary S, Buti S, et al
    Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer.
    Clin Cancer Res. 2023;29:2714-2724.
    PubMed     Abstract available

  18. THUMMALAPALLI R, Ricciuti B, Bandlamudi C, Muldoon D, et al
    Clinical and molecular features of long-term response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer.
    Clin Cancer Res. 2023 Jul 11:CCR-23-1207. doi: 10.1158/1078-0432.CCR-23-1207.
    PubMed     Abstract available

  19. COLLINS G, Stewart M, McKelvey B, Stires H, et al
    Breakthrough Therapy Designation Criteria Identify Drugs that Improve Clinical Outcomes for Patients: A Case for More Streamlined Coverage of Promising Therapies.
    Clin Cancer Res. 2023;29:2371-2374.
    PubMed     Abstract available

    June 2023
  20. CHAKRABORTY S, Coleman C, Manoj P, Demircioglu D, et al
    De novo and histologically transformed small cell lung cancer is sensitive to lurbinectedin treatment through the modulation of EMT and NOTCH signaling pathways.
    Clin Cancer Res. 2023 Jun 29:CCR-23-0471. doi: 10.1158/1078-0432.CCR-23-0471.
    PubMed     Abstract available

  21. GRAY JE, Ahn MJ, Oxnard GR, Shepherd FA, et al
    Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non-Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA.
    Clin Cancer Res. 2023 Jun 28:CCR-22-3146. doi: 10.1158/1078-0432.CCR-22-3146.
    PubMed     Abstract available

  22. KABRAJI S, Lin NU
    Keeping it in the family: HER3 as a target in brain metastases.
    Clin Cancer Res. 2023 Jun 12:CCR-23-1107. doi: 10.1158/1078-0432.CCR-23-1107.
    PubMed     Abstract available

  23. RAMKUMAR K, Tanimoto A, Della Corte CM, Stewart CA, et al
    Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer.
    Clin Cancer Res. 2023 Jun 8:CCR-23-0375. doi: 10.1158/1078-0432.CCR-23-0375.
    PubMed     Abstract available

  24. ANOBILE DP, Salaroglio IC, Tabbo F, La Vecchia S, et al
    Autocrine 17-beta-estradiol/estrogen receptor-alpha loop determines the response to immune-checkpoint inhibitors in non-small cell lung cancer.
    Clin Cancer Res. 2023 Jun 7:CCR-22-3949. doi: 10.1158/1078-0432.CCR-22-3949.
    PubMed     Abstract available

  25. PAWELETZ CP, Heavey GA, Kuang Y, Durlacher E, et al
    Early changes in circulating cell free KRAS G12C predicts response to adagrasib in KRAS mutant non-small cell lung cancer patients.
    Clin Cancer Res. 2023 Jun 6:CCR-23-0795. doi: 10.1158/1078-0432.CCR-23-0795.
    PubMed     Abstract available

    May 2023
  26. LIM SM, Fujino T, Kim C, Lee G, et al
    BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2023 May 30:CCR-22-3901. doi: 10.1158/1078-0432.CCR-22-3901.
    PubMed     Abstract available

  27. EISNER JR, Mayhew GM, Davison JM, Beebe KD, et al
    Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non-Small Cell Lung Cancer - The Piedmont Study.
    Clin Cancer Res. 2023 May 26:CCR-22-2558. doi: 10.1158/1078-0432.CCR-22-2558.
    PubMed     Abstract available

  28. GADGEEL SM, Miao J, Riess JW, Moon J, et al
    Phase II study of docetaxel and trametinib in patients with KRAS mutation positive recurrent non-small cell lung cancer (NSCLC) (SWOG S1507, NCT-02642042).
    Clin Cancer Res. 2023 May 26:CCR-22-3947. doi: 10.1158/1078-0432.CCR-22-3947.
    PubMed     Abstract available

  29. BHATT A, Schabath MB, Hoogland AI, Jim HSL, et al
    Patient-Reported Outcomes as Inter-Radiographic Predictors of Response in Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2023 May 26:CCR-23-0396. doi: 10.1158/1078-0432.CCR-23-0396.
    PubMed     Abstract available

  30. CHOUDHURY NJ, Lavery JA, Brown S, de Bruijn I, et al
    The GENIE BPC NSCLC cohort: a real-world repository integrating standardized clinical and genomic data for 1,846 patients with non-small cell lung cancer.
    Clin Cancer Res. 2023 May 24:CCR-23-0580. doi: 10.1158/1078-0432.CCR-23-0580.
    PubMed     Abstract available

  31. LIAM CK, Ahmad AR, Hsia TC, Zhou J, et al
    Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis.
    Clin Cancer Res. 2023;29:1879-1886.
    PubMed     Abstract available

    April 2023
  32. RICCIUTI B, Elkrief A, Alessi J, Wang X, et al
    Clinicopathologic, genomic, and immunophenotypic landscape of ATM mutations in non-small cell lung cancer.
    Clin Cancer Res. 2023 Apr 25:CCR-22-3413. doi: 10.1158/1078-0432.CCR-22-3413.
    PubMed     Abstract available

  33. PELLINI B, Chaudhuri AA
    ctDNA Monitoring for Small Cell Lung Cancer: Ready for Prime Time?
    Clin Cancer Res. 2023 Apr 25:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-0420.
    PubMed     Abstract available

  34. BLAQUIER JB, Ortiz-Cuaran S, Ricciuti B, Mezquita L, et al
    Tackling osimertinib resistance in EGFR mutant non-small cell lung cancer.
    Clin Cancer Res. 2023 Apr 24:CCR-22-1912. doi: 10.1158/1078-0432.CCR-22-1912.
    PubMed     Abstract available

  35. SIVAPALAN L, Iams WT, Belcaid Z, Scott SC, et al
    Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer.
    Clin Cancer Res. 2023 Apr 18:OF1-OF14. doi: 10.1158/1078-0432.CCR-22-2242.
    PubMed     Abstract available

    Liquid Biopsies for Cancer Genotyping: Coming of Age?
    Clin Cancer Res. 2023;29:1381-1383.
    PubMed     Abstract available

  37. ELKRIEF A, Makhnin A, Moses KA, Ahn LS, et al
    Brief Report: Combination of Osimertinib and Dacomitinib to Mitigate Primary and Acquired Resistance in EGFR-Mutant Lung Adenocarcinomas.
    Clin Cancer Res. 2023;29:1423-1428.
    PubMed     Abstract available

  38. TOMASICH E, Steindl A, Paiato C, Hatziioannou T, et al
    Frequent overexpression of HER3 in brain metastases from breast and lung cancer.
    Clin Cancer Res. 2023 Apr 10:CCR-23-0020. doi: 10.1158/1078-0432.CCR-23-0020.
    PubMed     Abstract available

  39. CHON K, Larkins E, Chatterjee S, Mishra-Kalyani PS, et al
    FDA Approval Summary: Amivantamab for the Treatment of patients with non-small cell lung cancer with EGFR exon 20 insertion mutations.
    Clin Cancer Res. 2023 Apr 6:CCR-22-3713. doi: 10.1158/1078-0432.CCR-22-3713.
    PubMed     Abstract available

  40. TUCKER ER, Jimenez I, Chen L, Bellini A, et al
    Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models.
    Clin Cancer Res. 2023;29:1317-1331.
    PubMed     Abstract available

  41. PATEL SA, Nilsson MB, Yang Y, Le X, et al
    IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC.
    Clin Cancer Res. 2023;29:1292-1304.
    PubMed     Abstract available

    March 2023
  42. XIA L, Yang Y, Chen W, Liu L, et al
    Perioperative ctDNA-Based MRD Detection in NSCLC-Response.
    Clin Cancer Res. 2023;29:1156.

  43. YU M, Ju L, Cao X
    Perioperative ctDNA-Based MRD Detection in NSCLC-Letter.
    Clin Cancer Res. 2023;29:1155.

  44. BRUNO R, Marchand M, Yoshida K, Chan P, et al
    Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150.
    Clin Cancer Res. 2023;29:1047-1055.
    PubMed     Abstract available

  45. GRANT MJ, Aredo JV, Starrett JH, Stockhammer P, et al
    Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations.
    Clin Cancer Res. 2023 Mar 13:CCR-22-3497. doi: 10.1158/1078-0432.CCR-22-3497.
    PubMed     Abstract available

  46. GURSKA LM, Okabe R, Schurer A, Tong MM, et al
    Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms.
    Clin Cancer Res. 2023;29:943-956.
    PubMed     Abstract available

    February 2023
  47. WILDSMITH S, Li W, Wu S, Stewart R, et al
    Tumor Mutational Burden as a Predictor of Survival With Durvalumab and/or Tremelimumab Treatment in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
    Clin Cancer Res. 2023 Feb 20:CCR-22-2765. doi: 10.1158/1078-0432.CCR-22-2765.
    PubMed     Abstract available

  48. ROSNER S, Reuss JE, Zahurak M, Zhang J, et al
    Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2023;29:705-710.
    PubMed     Abstract available

  49. WIJETUNGA NA, Goglia AG, Weinhold N, Berger MF, et al
    Dynamic Mutational Landscape of Cerebrospinal Fluid Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases.
    Clin Cancer Res. 2023;29:775-783.
    PubMed     Abstract available

  50. OWEN DH, Benner B, Wei L, Sukrithan V, et al
    A Phase II Clinical Trial of Nivolumab and Temozolomide for Neuroendocrine Neoplasms.
    Clin Cancer Res. 2023;29:731-741.
    PubMed     Abstract available

  51. ROSNER S, Reuss JE, Zahurak M, Zhang J, et al
    Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2023 Feb 15:OF1-OF6. doi: 10.1158/1078-0432.CCR-22-2994.
    PubMed     Abstract available

  52. LEE HS, Jang HJ, Ramineni M, Wang DY, et al
    A Phase II Window of Opportunity Study of Neoadjuvant PD-L1 versus PD-L1 plus CTLA-4 Blockade for Patients with Malignant Pleural Mesothelioma.
    Clin Cancer Res. 2023;29:548-559.
    PubMed     Abstract available

  53. AUGUSTIN RC, Bao R, Luke JJ
    Old Dog, New Trick: A Tumor-Intrinsic Role for PD-1 in Chemoresistant Tumor Subclones.
    Clin Cancer Res. 2023;29:505-507.
    PubMed     Abstract available

  54. WANG J, Guo W, Wang X, Tang X, et al
    Circulating Exosomal PD-L1 at Initial Diagnosis Predicts Outcome and Survival of Patients with Osteosarcoma.
    Clin Cancer Res. 2023;29:659-666.
    PubMed     Abstract available

    January 2023
  55. ZHANG Y, Tacheva-Grigorova SK, Sutton J, Melton Z, et al
    Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer.
    Clin Cancer Res. 2023 Jan 23:OF1-OF15. doi: 10.1158/1078-0432.CCR-22-2293.
    PubMed     Abstract available

  56. JONES R, Plummer R, Moreno V, Carter L, et al
    A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer.
    Clin Cancer Res. 2023;29:331-340.
    PubMed     Abstract available

  57. OH SY, Lee YW, Lee EJ, Kim JH, et al
    Preclinical Study of a Biparatopic METxMET Antibody-Drug Conjugate, REGN5093-M114, Overcomes MET-driven Acquired Resistance to EGFR TKIs in EGFR-mutant NSCLC.
    Clin Cancer Res. 2023;29:221-232.
    PubMed     Abstract available

  58. WAINBERG ZA, Singh AS, Konecny GE, McCann KE, et al
    Preclinical and Clinical Trial Results Using Talazoparib and Low-Dose Chemotherapy.
    Clin Cancer Res. 2023;29:40-49.
    PubMed     Abstract available

    December 2022
  59. PALANKI R, Swingle KL, Mitchell MJ
    A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma.
    Clin Cancer Res. 2022;28:5010-5012.
    PubMed     Abstract available

  60. NASH AM, Aghlara-Fotovat S, Castillio B, Hernandez A, et al
    Activation of Adaptive and Innate Immune Cells via Localized IL2 Cytokine Factories Eradicates Mesothelioma Tumors.
    Clin Cancer Res. 2022;28:5121-5135.
    PubMed     Abstract available

    November 2022
    Quantitative Spatial Profiling of TILs as the Next Step beyond PD-L1 Testing for Immune Checkpoint Blockade.
    Clin Cancer Res. 2022;28:4835-4837.
    PubMed     Abstract available

  62. LIM EA, Bendell JC, Falchook GS, Bauer TM, et al
    Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors.
    Clin Cancer Res. 2022;28:4871-4884.
    PubMed     Abstract available

  63. HUMMELINK K, van der Noort V, Muller M, Schouten RD, et al
    PD-1T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC.
    Clin Cancer Res. 2022;28:4893-4906.
    PubMed     Abstract available

  64. POULIKAKOS PI, Sullivan RJ, Yaeger R
    Molecular Pathways and Mechanisms of BRAF in Cancer Therapy.
    Clin Cancer Res. 2022;28:4618-4628.
    PubMed     Abstract available

    October 2022
  65. BRAMAN N, Prasanna P, Bera K, Alilou M, et al
    Novel Radiomic Measurements of Tumor-Associated Vasculature Morphology on Clinical Imaging as a Biomarker of Treatment Response in Multiple Cancers.
    Clin Cancer Res. 2022;28:4410-4424.
    PubMed     Abstract available

  66. SUGIMOTO A, Matsumoto S, Udagawa H, Itotani R, et al
    A large-scale prospective concordance study of plasma- and tissue-based next-generation targeted sequencing for advanced non-small cell lung cancer (LC-SCRUM-Liquid).
    Clin Cancer Res. 2022 Oct 6. pii: 709652. doi: 10.1158/1078-0432.CCR-22-1749.
    PubMed     Abstract available

  67. JUNG HA, Lim J, Choi YL, Lee SH, et al
    Clinical, Pathologic, and Molecular Prognostic Factors in Patients with Early-Stage EGFR-Mutant NSCLC.
    Clin Cancer Res. 2022;28:4312-4321.
    PubMed     Abstract available

    September 2022
  68. ROCHIGNEUX P, Lisberg A, Garcia A, Granjeaud S, et al
    Mass cytometry reveals classical monocytes, NK cells and ICOS+ CD4+ T cells associated with pembrolizumab efficacy in lung cancer patients.
    Clin Cancer Res. 2022 Sep 27. pii: 709487. doi: 10.1158/1078-0432.CCR-22-1386.
    PubMed     Abstract available

  69. ROTOLO R, Leuci V, Donini C, Galvagno F, et al
    Novel lymphocyte-independent antitumor activity by PD-1 blocking antibody against PD-1+ chemoresistant lung cancer cells.
    Clin Cancer Res. 2022 Sep 27. pii: 709485. doi: 10.1158/1078-0432.CCR-22-0761.
    PubMed     Abstract available

  70. DUKE ES, Stapleford L, Drezner N, Amatya AK, et al
    FDA Approval Summary: Mobocertinib for Metastatic Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations.
    Clin Cancer Res. 2022 Sep 16. pii: 709236. doi: 10.1158/1078-0432.CCR-22-2072.
    PubMed     Abstract available

  71. GUIDRY K, Vasudevaraja V, Labbe K, Mohamed H, et al
    DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome.
    Clin Cancer Res. 2022;28:3824-3835.
    PubMed     Abstract available

  72. KENNEDY GT, Holt DE, Azari FS, Bernstein E, et al
    A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection.
    Clin Cancer Res. 2022;28:3729-3741.
    PubMed     Abstract available

  73. MACK PC, Miao J, Redman MW, Moon J, et al
    Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI-Treated Patients with EGFR-Mutant NSCLC (SWOG S1403).
    Clin Cancer Res. 2022;28:3752-3760.
    PubMed     Abstract available

  74. YAP TA, Gainor JF, Callahan MK, Falchook GS, et al
    First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response.
    Clin Cancer Res. 2022;28:3695-3708.
    PubMed     Abstract available

    August 2022
  75. MAHADEVAN NR, Sholl LM
    To Rb or Not to Rb: Uncovering Unique Subsets of Small Cell Lung Carcinoma.
    Clin Cancer Res. 2022 Aug 31. pii: 708945. doi: 10.1158/1078-0432.CCR-22-2187.
    PubMed     Abstract available

  76. TANIGUCHI Y, Shimokawa T, Takiguchi Y, Misumi T, et al
    A randomized comparison of nivolumab versus nivolumab + docetaxel for previously treated advanced or recurrent ICI-naive non-small-cell lung cancer: TORG1630.
    Clin Cancer Res. 2022 Aug 18. pii: 708059. doi: 10.1158/1078-0432.CCR-22-1687.
    PubMed     Abstract available

  77. OZCAN G, Singh M, Vredenburgh JJ
    Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
    Clin Cancer Res. 2022 Aug 16. pii: 707826. doi: 10.1158/1078-0432.CCR-22-1585.
    PubMed     Abstract available

  78. KIM TW, Burris HA, de Miguel Luken MJ, Pishvaian MJ, et al
    First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors.
    Clin Cancer Res. 2022;28:3452-3463.
    PubMed     Abstract available

  79. HIATT JB, Sandborg H, Garrison SM, Arnold HU, et al
    Inhibition of LSD1 with bomedemstat sensitizes small cell lung cancer to immune checkpoint blockade and T cell killing.
    Clin Cancer Res. 2022 Aug 3. pii: 707373. doi: 10.1158/1078-0432.CCR-22-1128.
    PubMed     Abstract available

  80. WEI S, Gao X, Tang M, Li J, et al
    Perioperative ctDNA-Based MRD Detection in NSCLC- Letter.
    Clin Cancer Res. 2022;28:3400.

  81. XIA L, Chen W, Liu L
    Perioperative ctDNA-Based MRD Detection in NSCLC-Response.
    Clin Cancer Res. 2022;28:3401.

    July 2022
  82. HUNIHAN L, Zhao D, Lazowski H, Li M, et al
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition.
    Clin Cancer Res. 2022;28:3091-3103.
    PubMed     Abstract available

  83. BARLESI F, Tomasini P, Karimi M, Michiels S, et al
    Comprehensive genome profiling in patients with metastatic non-small cell lung cancer: the precision medicine phase 2 randomized SAFIR02-Lung trial.
    Clin Cancer Res. 2022 Jul 8. pii: 706925. doi: 10.1158/1078-0432.CCR-22-0371.
    PubMed     Abstract available

  84. FEBRES ALDANA CA, Chang JC, Ptashkin R, Wang Y, et al
    Rb tumor suppressor in small cell lung cancer: Combined genomic and immunohistochemical analysis with a description of a distinct Rb-proficient subset.
    Clin Cancer Res. 2022 Jul 6. pii: 706889. doi: 10.1158/1078-0432.CCR-22-1115.
    PubMed     Abstract available

    June 2022
  85. SCHOENFELD AJ, Rizvi HA, Memon D, Shaverdian N, et al
    Systemic and oligo-acquired resistance to PD-(L)1 blockade in lung cancer.
    Clin Cancer Res. 2022 Jun 29. pii: 705289. doi: 10.1158/1078-0432.CCR-22-0657.
    PubMed     Abstract available

  86. AKAMATSU H, Teraoka S, Takamori S, Miura S, et al
    Nivolumab Retreatment in Non-Small Cell Lung Cancer Patients Who Responded to Prior Immune Checkpoint Inhibitors and Had ICI-Free Intervals (WJOG9616L).
    Clin Cancer Res. 2022 Jun 28:OF1-OF7. doi: 10.1158/1078-0432.CCR-22-0602.
    PubMed     Abstract available

  87. YANG JC, Ohe Y, Chiu CH, Ou X, et al
    Osimertinib plus Selumetinib in EGFR-Mutated Non-Small Cell Lung Cancer After Progression on EGFR-TKIs: A Phase Ib, Open-Label, Multicenter Trial (TATTON Part B).
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    FOXM1 variant contributes to gefitinib resistance via activating wnt/beta-catenin signal pathway in non-small cell lung cancer patients.
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  89. MURCIANO-GOROFF YR, Harada G, Drilon A
    An Ascendant Challenge: Central Nervous System Metastases in ALK+ Lung Cancers.
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    Targeting Podoplanin for the Treatment of Osteosarcoma.
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    Searching for Synergy: Chemotherapy and Checkpoint Inhibitors.
    Clin Cancer Res. 2022;28:2206-2208.
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  93. PATIL T, Bunn PA
    Adjuvant Osimertinib in EGFR-Mutant Early-Stage NSCLC: Does HRQoL Influence Decisions?
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  94. CHOUDHURY AD, Higano CS, de Bono JS, Cook N, et al
    A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kbeta/delta, in Patients with Advanced Solid Tumors.
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  95. AKINBORO O, Larkins E, Pai-Scherf LH, Mathieu LN, et al
    FDA Approval Summary: Pembrolizumab, Atezolizumab, and Cemiplimab-rwlc as Single Agents for First-Line Treatment of Advanced/Metastatic PD-L1-High NSCLC.
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    Continuation of Pembrolizumab with Additional Chemotherapy after Progression with PD-1/PD-L1 Inhibitor Monotherapy in Patients with Advanced NSCLC: A Randomized, Placebo-Controlled Phase II Study.
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    Nivolumab retreatment in non-small cell lung cancer patients who responded to prior immune-checkpoint inhibitors and had ICI-free intervals (WJOG9616L).
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    Osimertinib plus selumetinib in EGFR-mutated, non-small cell lung cancer after progression on EGFR-TKIs: A Phase 1b, open-label, multicenter trial (TATTON Part B).
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  99. KOMMALAPATI A, Mansfield AS
    Trials, tribunals, and opportunities for lung cancer KRASG12C brain metastases.
    Clin Cancer Res. 2022 May 24. pii: 699172. doi: 10.1158/1078-0432.CCR-22-1137.
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    Expanding Therapeutic Opportunities for Extrapulmonary Neuroendocrine Carcinoma.
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    All about that Ras: Novel fusion drives Ras pathway activation in lung cancer.
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    Replication of overall survival, progression-free survival, and overall response in chemotherapy arms of non-small cell lung cancer trials using real-world data.
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    FDA Approval Summary: Sotorasib for KRAS G12C-Mutated Metastatic NSCLC.
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    Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data From Patients With KRASG12C-Mutant Non-Small Cell Lung Cancer.
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  106. DEMETRI GD, De Braud F, Drilon A, Siena S, et al
    Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With NTRK Fusion-Positive Solid Tumors.
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    March 2022
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    Has the Enemy "MET" Its Match? Subgroup Analysis Results from VISION Study.
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  108. LE X, Sakai H, Felip E, Veillon R, et al
    Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice.
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    Circulating Cell-free DNA as a Prognostic Biomarker in Patients with Advanced ALK+ Non-small Cell Lung Cancer in the Global Phase III ALEX Trial.
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  110. CHIAPPORI AA, Creelan B, Tanvetyanon T, Gray JE, et al
    Phase I study of taminadenant (PBF509/NIR178), an adenosine 2A receptor antagonist, with or without spartalizumab, in patients with advanced non-small cell lung cancer.
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  111. HAYASHI H, Sugawara S, Fukuda Y, Fujimoto D, et al
    A Randomized Phase II Study Comparing Nivolumab with Carboplatin-Pemetrexed for EGFR-Mutated NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors (WJOG8515L).
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    February 2022
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    ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients With ALK-Positive Non-Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges.
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    Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer exhibits antitumor efficacy with low toxicity.
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    Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer who underwent Adjuvant Osimertinib in the phase III ADAURA trial.
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    Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib.
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    November 2021
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    A novel third generation EGFR tyrosine kinase inhibitor Abivertinib for EGFR T790M mutant Non-Small Cell Lung Cancer: a multicenter phase1/2 study.
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    Adding Base Excision Repair Inhibitor TRC102 to standard Pemetrexed-Platinum-Radiation in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: Results of a phase I trial.
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    Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy.
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    Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities.
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    October 2021
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    Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non-Small Cell Lung Cancer.
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    September 2021
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    TAS-116 plus nivolumab in patients with colorectal cancer and other solid tumors: an, open-label, dose-finding, and expansion phase Ib trial (EPOC1704).
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    August 2021
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    Genomic landscape and tumor mutational burden determination of circulating tumor DNA in over 5,000 Chinese lung cancer patients.
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    Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes.
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    Immunotherapy-mediated thyroid dysfunction: genetic risk and impact on outcomes with PD-1 blockade in non-small cell lung cancer.
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    Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912).
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    May 2021
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