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Articles published in Clin Cancer Res

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Single Articles


    November 2022
  1. ANAGNOSTOU V, Luke JJ
    Quantitative Spatial Profiling of TILs as the Next Step beyond PD-L1 Testing for Immune Checkpoint Blockade.
    Clin Cancer Res. 2022;28:4835-4837.
    PubMed     Abstract available


  2. LIM EA, Bendell JC, Falchook GS, Bauer TM, et al
    Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors.
    Clin Cancer Res. 2022;28:4871-4884.
    PubMed     Abstract available


  3. HUMMELINK K, van der Noort V, Muller M, Schouten RD, et al
    PD-1T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC.
    Clin Cancer Res. 2022;28:4893-4906.
    PubMed     Abstract available


  4. POULIKAKOS PI, Sullivan RJ, Yaeger R
    Molecular Pathways and Mechanisms of BRAF in Cancer Therapy.
    Clin Cancer Res. 2022;28:4618-4628.
    PubMed     Abstract available


    October 2022
  5. BRAMAN N, Prasanna P, Bera K, Alilou M, et al
    Novel Radiomic Measurements of Tumor-Associated Vasculature Morphology on Clinical Imaging as a Biomarker of Treatment Response in Multiple Cancers.
    Clin Cancer Res. 2022;28:4410-4424.
    PubMed     Abstract available


  6. SUGIMOTO A, Matsumoto S, Udagawa H, Itotani R, et al
    A large-scale prospective concordance study of plasma- and tissue-based next-generation targeted sequencing for advanced non-small cell lung cancer (LC-SCRUM-Liquid).
    Clin Cancer Res. 2022 Oct 6. pii: 709652. doi: 10.1158/1078-0432.CCR-22-1749.
    PubMed     Abstract available


  7. JUNG HA, Lim J, Choi YL, Lee SH, et al
    Clinical, Pathologic, and Molecular Prognostic Factors in Patients with Early-Stage EGFR-Mutant NSCLC.
    Clin Cancer Res. 2022;28:4312-4321.
    PubMed     Abstract available


    September 2022
  8. ROCHIGNEUX P, Lisberg A, Garcia A, Granjeaud S, et al
    Mass cytometry reveals classical monocytes, NK cells and ICOS+ CD4+ T cells associated with pembrolizumab efficacy in lung cancer patients.
    Clin Cancer Res. 2022 Sep 27. pii: 709487. doi: 10.1158/1078-0432.CCR-22-1386.
    PubMed     Abstract available


  9. ROTOLO R, Leuci V, Donini C, Galvagno F, et al
    Novel lymphocyte-independent antitumor activity by PD-1 blocking antibody against PD-1+ chemoresistant lung cancer cells.
    Clin Cancer Res. 2022 Sep 27. pii: 709485. doi: 10.1158/1078-0432.CCR-22-0761.
    PubMed     Abstract available


  10. DUKE ES, Stapleford L, Drezner N, Amatya AK, et al
    FDA Approval Summary: Mobocertinib for Metastatic Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations.
    Clin Cancer Res. 2022 Sep 16. pii: 709236. doi: 10.1158/1078-0432.CCR-22-2072.
    PubMed     Abstract available


  11. GUIDRY K, Vasudevaraja V, Labbe K, Mohamed H, et al
    DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome.
    Clin Cancer Res. 2022;28:3824-3835.
    PubMed     Abstract available


  12. KENNEDY GT, Holt DE, Azari FS, Bernstein E, et al
    A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection.
    Clin Cancer Res. 2022;28:3729-3741.
    PubMed     Abstract available


  13. MACK PC, Miao J, Redman MW, Moon J, et al
    Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI-Treated Patients with EGFR-Mutant NSCLC (SWOG S1403).
    Clin Cancer Res. 2022;28:3752-3760.
    PubMed     Abstract available


  14. YAP TA, Gainor JF, Callahan MK, Falchook GS, et al
    First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response.
    Clin Cancer Res. 2022;28:3695-3708.
    PubMed     Abstract available


    August 2022
  15. MAHADEVAN NR, Sholl LM
    To Rb or Not to Rb: Uncovering Unique Subsets of Small Cell Lung Carcinoma.
    Clin Cancer Res. 2022 Aug 31. pii: 708945. doi: 10.1158/1078-0432.CCR-22-2187.
    PubMed     Abstract available


  16. TANIGUCHI Y, Shimokawa T, Takiguchi Y, Misumi T, et al
    A randomized comparison of nivolumab versus nivolumab + docetaxel for previously treated advanced or recurrent ICI-naive non-small-cell lung cancer: TORG1630.
    Clin Cancer Res. 2022 Aug 18. pii: 708059. doi: 10.1158/1078-0432.CCR-22-1687.
    PubMed     Abstract available


  17. OZCAN G, Singh M, Vredenburgh JJ
    Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
    Clin Cancer Res. 2022 Aug 16. pii: 707826. doi: 10.1158/1078-0432.CCR-22-1585.
    PubMed     Abstract available


  18. KIM TW, Burris HA, de Miguel Luken MJ, Pishvaian MJ, et al
    First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors.
    Clin Cancer Res. 2022;28:3452-3463.
    PubMed     Abstract available


  19. HIATT JB, Sandborg H, Garrison SM, Arnold HU, et al
    Inhibition of LSD1 with bomedemstat sensitizes small cell lung cancer to immune checkpoint blockade and T cell killing.
    Clin Cancer Res. 2022 Aug 3. pii: 707373. doi: 10.1158/1078-0432.CCR-22-1128.
    PubMed     Abstract available


  20. WEI S, Gao X, Tang M, Li J, et al
    Perioperative ctDNA-Based MRD Detection in NSCLC- Letter.
    Clin Cancer Res. 2022;28:3400.
    PubMed    


  21. XIA L, Chen W, Liu L
    Perioperative ctDNA-Based MRD Detection in NSCLC-Response.
    Clin Cancer Res. 2022;28:3401.
    PubMed    


    July 2022
  22. HUNIHAN L, Zhao D, Lazowski H, Li M, et al
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition.
    Clin Cancer Res. 2022;28:3091-3103.
    PubMed     Abstract available


  23. BARLESI F, Tomasini P, Karimi M, Michiels S, et al
    Comprehensive genome profiling in patients with metastatic non-small cell lung cancer: the precision medicine phase 2 randomized SAFIR02-Lung trial.
    Clin Cancer Res. 2022 Jul 8. pii: 706925. doi: 10.1158/1078-0432.CCR-22-0371.
    PubMed     Abstract available


  24. FEBRES ALDANA CA, Chang JC, Ptashkin R, Wang Y, et al
    Rb tumor suppressor in small cell lung cancer: Combined genomic and immunohistochemical analysis with a description of a distinct Rb-proficient subset.
    Clin Cancer Res. 2022 Jul 6. pii: 706889. doi: 10.1158/1078-0432.CCR-22-1115.
    PubMed     Abstract available


    June 2022
  25. SCHOENFELD AJ, Rizvi HA, Memon D, Shaverdian N, et al
    Systemic and oligo-acquired resistance to PD-(L)1 blockade in lung cancer.
    Clin Cancer Res. 2022 Jun 29. pii: 705289. doi: 10.1158/1078-0432.CCR-22-0657.
    PubMed     Abstract available


  26. AKAMATSU H, Teraoka S, Takamori S, Miura S, et al
    Nivolumab Retreatment in Non-Small Cell Lung Cancer Patients Who Responded to Prior Immune Checkpoint Inhibitors and Had ICI-Free Intervals (WJOG9616L).
    Clin Cancer Res. 2022 Jun 28:OF1-OF7. doi: 10.1158/1078-0432.CCR-22-0602.
    PubMed     Abstract available


  27. YANG JC, Ohe Y, Chiu CH, Ou X, et al
    Osimertinib plus Selumetinib in EGFR-Mutated Non-Small Cell Lung Cancer After Progression on EGFR-TKIs: A Phase Ib, Open-Label, Multicenter Trial (TATTON Part B).
    Clin Cancer Res. 2022 Jun 23:OF1-OF10. doi: 10.1158/1078-0432.CCR-21-4329.
    PubMed     Abstract available


  28. GUAN S, Chen X, Chen Y, Xie W, et al
    FOXM1 variant contributes to gefitinib resistance via activating wnt/beta-catenin signal pathway in non-small cell lung cancer patients.
    Clin Cancer Res. 2022 Jun 13. pii: 704872. doi: 10.1158/1078-0432.CCR-22-0791.
    PubMed     Abstract available


  29. MURCIANO-GOROFF YR, Harada G, Drilon A
    An Ascendant Challenge: Central Nervous System Metastases in ALK+ Lung Cancers.
    Clin Cancer Res. 2022;28:2477-2479.
    PubMed     Abstract available


  30. TAKEMOTO A, Takagi S, Ukaji T, Gyobu N, et al
    Targeting Podoplanin for the Treatment of Osteosarcoma.
    Clin Cancer Res. 2022;28:2633-2645.
    PubMed     Abstract available


  31. ROCHA P, Zhang J, Laza-Briviesca R, Cruz-Bermudez A, et al
    Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC.
    Clin Cancer Res. 2022;28:2461-2473.
    PubMed     Abstract available


  32. TSENG D, Gainor JF
    Searching for Synergy: Chemotherapy and Checkpoint Inhibitors.
    Clin Cancer Res. 2022;28:2206-2208.
    PubMed     Abstract available


  33. PATIL T, Bunn PA
    Adjuvant Osimertinib in EGFR-Mutant Early-Stage NSCLC: Does HRQoL Influence Decisions?
    Clin Cancer Res. 2022;28:2204-2205.
    PubMed     Abstract available


  34. CHOUDHURY AD, Higano CS, de Bono JS, Cook N, et al
    A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kbeta/delta, in Patients with Advanced Solid Tumors.
    Clin Cancer Res. 2022;28:2257-2269.
    PubMed     Abstract available


  35. AKINBORO O, Larkins E, Pai-Scherf LH, Mathieu LN, et al
    FDA Approval Summary: Pembrolizumab, Atezolizumab, and Cemiplimab-rwlc as Single Agents for First-Line Treatment of Advanced/Metastatic PD-L1-High NSCLC.
    Clin Cancer Res. 2022;28:2221-2228.
    PubMed     Abstract available


  36. JUNG HA, Park S, Choi YL, Lee SH, et al
    Continuation of Pembrolizumab with Additional Chemotherapy after Progression with PD-1/PD-L1 Inhibitor Monotherapy in Patients with Advanced NSCLC: A Randomized, Placebo-Controlled Phase II Study.
    Clin Cancer Res. 2022;28:2321-2328.
    PubMed     Abstract available


    May 2022
  37. AKAMATSU H, Teraoka S, Takamori S, Miura S, et al
    Nivolumab retreatment in non-small cell lung cancer patients who responded to prior immune-checkpoint inhibitors and had ICI-free intervals (WJOG9616L).
    Clin Cancer Res. 2022 May 26. pii: 699251. doi: 10.1158/1078-0432.CCR-22-0602.
    PubMed     Abstract available


  38. YANG JC, Ohe Y, Chiu CH, Ou X, et al
    Osimertinib plus selumetinib in EGFR-mutated, non-small cell lung cancer after progression on EGFR-TKIs: A Phase 1b, open-label, multicenter trial (TATTON Part B).
    Clin Cancer Res. 2022 May 26. pii: 699247. doi: 10.1158/1078-0432.CCR-21-4329.
    PubMed     Abstract available


  39. KOMMALAPATI A, Mansfield AS
    Trials, tribunals, and opportunities for lung cancer KRASG12C brain metastases.
    Clin Cancer Res. 2022 May 24. pii: 699172. doi: 10.1158/1078-0432.CCR-22-1137.
    PubMed     Abstract available


  40. FRIZZIERO M, Kilgour E, Simpson KL, Rothwell DG, et al
    Expanding Therapeutic Opportunities for Extrapulmonary Neuroendocrine Carcinoma.
    Clin Cancer Res. 2022;28:1999-2019.
    PubMed     Abstract available


  41. MOORTHI S, Berger AH
    All about that Ras: Novel fusion drives Ras pathway activation in lung cancer.
    Clin Cancer Res. 2022 May 5. pii: 696314. doi: 10.1158/1078-0432.CCR-22-0736.
    PubMed     Abstract available


  42. TON TGN, Pal N, Trinh H, Mahrus S, et al
    Replication of overall survival, progression-free survival, and overall response in chemotherapy arms of non-small cell lung cancer trials using real-world data.
    Clin Cancer Res. 2022 May 5. pii: 696304. doi: 10.1158/1078-0432.CCR-22-0471.
    PubMed     Abstract available


    April 2022
  43. SONG L, Xiong H, Li J, Liao W, et al
    Correction: Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NFkappaB Pathway in Human Non-small Cell Lung Cancer.
    Clin Cancer Res. 2022;28:1740.
    PubMed    


  44. NAKAJIMA EC, Drezner N, Li X, Mishra-Kalyani PS, et al
    FDA Approval Summary: Sotorasib for KRAS G12C-Mutated Metastatic NSCLC.
    Clin Cancer Res. 2022;28:1482-1486.
    PubMed     Abstract available


  45. SABARI JK, Velcheti V, Shimizu K, Strickland MR, et al
    Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data From Patients With KRASG12C-Mutant Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2022 Apr 11. pii: 694212. doi: 10.1158/1078-0432.CCR-22-0383.
    PubMed     Abstract available


  46. DEMETRI GD, De Braud F, Drilon A, Siena S, et al
    Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With NTRK Fusion-Positive Solid Tumors.
    Clin Cancer Res. 2022;28:1302-1312.
    PubMed     Abstract available


    March 2022
  47. ROSNER S, Spira AI
    Has the Enemy "MET" Its Match? Subgroup Analysis Results from VISION Study.
    Clin Cancer Res. 2022;28:1055-1057.
    PubMed     Abstract available


  48. LE X, Sakai H, Felip E, Veillon R, et al
    Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice.
    Clin Cancer Res. 2022;28:1117-1126.
    PubMed     Abstract available


  49. DZIADZIUSZKO R, Peters S, Mok T, Camidge DR, et al
    Circulating Cell-free DNA as a Prognostic Biomarker in Patients with Advanced ALK+ Non-small Cell Lung Cancer in the Global Phase III ALEX Trial.
    Clin Cancer Res. 2022 Mar 11. pii: 681795. doi: 10.1158/1078-0432.CCR-21-2840.
    PubMed     Abstract available


  50. CHIAPPORI AA, Creelan B, Tanvetyanon T, Gray JE, et al
    Phase I study of taminadenant (PBF509/NIR178), an adenosine 2A receptor antagonist, with or without spartalizumab, in patients with advanced non-small cell lung cancer.
    Clin Cancer Res. 2022 Mar 7. pii: 682078. doi: 10.1158/1078-0432.CCR-21-2742.
    PubMed     Abstract available


  51. HAYASHI H, Sugawara S, Fukuda Y, Fujimoto D, et al
    A Randomized Phase II Study Comparing Nivolumab with Carboplatin-Pemetrexed for EGFR-Mutated NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors (WJOG8515L).
    Clin Cancer Res. 2022;28:893-902.
    PubMed     Abstract available


    February 2022
  52. LEE JK, Hazar-Rethinam M, Decker B, Gjoerup O, et al
    The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA.
    Clin Cancer Res. 2022;28:728-737.
    PubMed     Abstract available


  53. MAJEED S, Aparnathi MK, Nixon KCJ, Venkatasubramanian V, et al
    Targeting the ubiquitin-proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small cell lung cancer.
    Clin Cancer Res. 2022 Feb 14. pii: 1078-0432.CCR-21-0344.
    PubMed     Abstract available


  54. MAJEED S, Aparnathi MK, Nixon KCJ, Venkatasubramanian V, et al
    Targeting the ubiquitin-proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small cell lung cancer.
    Clin Cancer Res. 2022 Feb 11. pii: 681703. doi: 10.1158/1078-0432.CCR-21-0344.
    PubMed     Abstract available


  55. NAKAJIMA EC, Vellanki PJ, Larkins E, Chatterjee S, et al
    FDA Approval Summary: Nivolumab in Combination with Ipilimumab for the Treatment of Unresectable Malignant Pleural Mesothelioma.
    Clin Cancer Res. 2022;28:446-451.
    PubMed     Abstract available


    January 2022
  56. CHOW LQM, Barlesi F, Bertino EM, van den Bent MJ, et al
    ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients With ALK-Positive Non-Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges.
    Clin Cancer Res. 2022 Jan 28. pii: 1078-0432.CCR-21-1838.
    PubMed     Abstract available


  57. RICCIUTI B, Son J, Okoro JJ, Mira A, et al
    Comparative analysis and isoform-specific therapeutic vulnerabilities of KRAS mutations in non-small cell lung cancer.
    Clin Cancer Res. 2022 Jan 28. pii: 1078-0432.CCR-21-2719.
    PubMed     Abstract available


  58. TULLY KM, Tendler S, Carter LM, Sharma SK, et al
    Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer exhibits antitumor efficacy with low toxicity.
    Clin Cancer Res. 2022 Jan 19. pii: 1078-0432.CCR-21-1533.
    PubMed     Abstract available


  59. SUZUKI S, Yonesaka K, Teramura T, Takehara T, et al
    Correction: KRAS Inhibitor Resistance in MET-Amplified KRAS (G12C) Non-Small Cell Lung Cancer Induced By RAS- and Non-RAS-Mediated Cell Signaling Mechanisms.
    Clin Cancer Res. 2022;28:428.
    PubMed    


  60. MATHIEU LN, Larkins E, Akinboro O, Roy P, et al
    FDA Approval Summary: Capmatinib and Tepotinib for the Treatment of Metastatic NSCLC Harboring MET Exon 14 Skipping Mutations or Alterations.
    Clin Cancer Res. 2022;28:249-254.
    PubMed     Abstract available


  61. MAJEM M, Goldman JW, John T, Grohe C, et al
    Health-Related Quality of Life Outcomes in Patients with Resected Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer who underwent Adjuvant Osimertinib in the phase III ADAURA trial.
    Clin Cancer Res. 2022 Jan 10. pii: 1078-0432.CCR-21-3530.
    PubMed     Abstract available


  62. GAO Y, Paivinen P, Tripathi S, Domenech-Moreno E, et al
    Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma.
    Clin Cancer Res. 2022;28:227-237.
    PubMed     Abstract available


  63. LEE JC, Green MD, Huppert LA, Chow C, et al
    The Liver-Immunity Nexus and Cancer Immunotherapy.
    Clin Cancer Res. 2022;28:5-12.
    PubMed     Abstract available


    December 2021
  64. YONESAKA K, Tanizaki J, Maenishi O, Haratani K, et al
    HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2021 Dec 17. pii: 1078-0432.CCR-21-3359.
    PubMed     Abstract available


  65. JIN Y, Chen Y, Tang H, Hubert SM, et al
    Activation of PI3K/AKT pathway is a potential mechanism of treatment resistance in small cell lung cancer.
    Clin Cancer Res. 2021 Dec 17. pii: 1078-0432.CCR-21-1943.
    PubMed     Abstract available


  66. DI NOIA V, Pimpinelli F, Renna D, Barberi V, et al
    Immunogenicity and Safety of COVID-19 Vaccine BNT162b2 for Patients with Solid Cancer: A Large Cohort Prospective Study from a Single Institution.
    Clin Cancer Res. 2021;27:6815-6823.
    PubMed     Abstract available


  67. HANNAN R, Mohamad O, Diaz de Leon A, Manna S, et al
    Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma.
    Clin Cancer Res. 2021;27:6716-6725.
    PubMed     Abstract available


  68. LEE CJ, Schoffski P, Modave E, van Wezel T, et al
    Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib.
    Clin Cancer Res. 2021;27:6737-6748.
    PubMed     Abstract available


    November 2021
  69. XIA L, Mei J, Kang R, Deng S, et al
    Perioperative ctDNA-based Molecular Residual Disease Detection for Non-Small Cell Lung Cancer: A Prospective Multicenter Cohort Study (LUNGCA-1).
    Clin Cancer Res. 2021 Nov 29. pii: 1078-0432.CCR-21-3044.
    PubMed     Abstract available


  70. SONG Z, Lv D, Chen SQ, Huang J, et al
    Pyrotinib in Patients with HER2-Amplified Advanced Non-Small Cell Lung Cancer: A Prospective, Multicenter, Single-Arm Trial.
    Clin Cancer Res. 2021 Nov 9. pii: 1078-0432.CCR-21-2936.
    PubMed     Abstract available


  71. ZHOU Q, Wu L, Hu P, An T, et al
    A novel third generation EGFR tyrosine kinase inhibitor Abivertinib for EGFR T790M mutant Non-Small Cell Lung Cancer: a multicenter phase1/2 study.
    Clin Cancer Res. 2021 Nov 5. pii: 1078-0432.CCR-21-2595.
    PubMed     Abstract available


  72. BISWAS T, Dowlati A, Kunos CA, Pink JJ, et al
    Adding Base Excision Repair Inhibitor TRC102 to standard Pemetrexed-Platinum-Radiation in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: Results of a phase I trial.
    Clin Cancer Res. 2021 Nov 5. pii: 1078-0432.CCR-21-2025.
    PubMed     Abstract available


  73. CASARRUBIOS M, Cruz-Bermudez A, Nadal E, Insa A, et al
    Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy.
    Clin Cancer Res. 2021;27:5878-5890.
    PubMed     Abstract available


  74. CHUA KP, Teng YHF, Tan AC, Takano A, et al
    Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities.
    Clin Cancer Res. 2021;27:5939-5950.
    PubMed     Abstract available


    October 2021
  75. MEHTA S, Fiorelli R, Bao X, Pennington-Krygier C, et al
    A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma.
    Clin Cancer Res. 2021 Oct 26. pii: 1078-0432.CCR-21-1096.
    PubMed     Abstract available


  76. GAVRIELATOU N, Liu Y, Vathiotis I, Zugazagoitia J, et al
    Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2021 Oct 22. pii: 1078-0432.CCR-21-2649.
    PubMed     Abstract available


    September 2021
  77. KAWAZOE A, Itahashi K, Yamamoto N, Kotani D, et al
    TAS-116 plus nivolumab in patients with colorectal cancer and other solid tumors: an, open-label, dose-finding, and expansion phase Ib trial (EPOC1704).
    Clin Cancer Res. 2021 Sep 30. pii: 1078-0432.CCR-21-1929.
    PubMed     Abstract available


  78. PORCIUNCULA A, Morgado M, Gupta R, Syrigos K, et al
    Spatial mapping and immunomodulatory role of the OX40/OX40L pathway in human non-small cell lung cancer.
    Clin Cancer Res. 2021 Sep 13. pii: 1078-0432.CCR-21-0987.
    PubMed     Abstract available


    August 2021
  79. SHI J, Wang Z, Zhang J, Xu Y, et al
    Genomic landscape and tumor mutational burden determination of circulating tumor DNA in over 5,000 Chinese lung cancer patients.
    Clin Cancer Res. 2021 Aug 26. pii: 1078-0432.CCR-21-1537.
    PubMed     Abstract available


  80. CAMIDGE DR, Morgensztern D, Heist RS, Barve M, et al
    Phase 1 Study of 2- or 3-Week Dosing of Telisotuzumab Vedotin, an Antibody-Drug Conjugate Targeting c-Met, Monotherapy in Patients With Advanced Non-Small Cell Lung Carcinoma.
    Clin Cancer Res. 2021 Aug 23. pii: 1078-0432.CCR-21-0765.
    PubMed     Abstract available


  81. MAITLAND ML, Sachdev JC, Sharma MR, Moreno V, et al
    First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
    Clin Cancer Res. 2021;27:4511-4520.
    PubMed     Abstract available


  82. SUZUKI S, Yonesaka K, Teramura T, Takehara T, et al
    KRAS inhibitor-resistance in MET-amplified KRAS (G12C) non-small cell lung cancer induced by RAS- and non-RAS-mediated cell signaling mechanisms.
    Clin Cancer Res. 2021 Aug 7. pii: 1078-0432.CCR-21-0856.
    PubMed     Abstract available


  83. SUBBIAH V, Gainor JF, Oxnard GR, Tan DSW, et al
    Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non-Small Cell Lung Cancers on the LIBRETTO-001 Trial.
    Clin Cancer Res. 2021;27:4160-4167.
    PubMed     Abstract available


  84. KIM SY, Kim SM, Lim S, Lee JY, et al
    Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.
    Clin Cancer Res. 2021;27:4397-4409.
    PubMed     Abstract available


  85. CONFORTI F, Pala L, Pagan E, Bagnardi V, et al
    Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion.
    Clin Cancer Res. 2021;27:4311-4324.
    PubMed     Abstract available


    July 2021
  86. NAKAGAWA K, Nadal E, Garon EB, Nishio M, et al
    RELAY Subgroup Analyses by EGFR Ex19del and Ex21L858R Mutations for Ramucirumab Plus Erlotinib in Metastatic Non-small Cell Lung Cancer.
    Clin Cancer Res. 2021 Jul 22. pii: 1078-0432.CCR-21-0273.
    PubMed     Abstract available


  87. KOCH AL, Vellanki PJ, Drezner N, Li X, et al
    FDA Approval Summary: Osimertinib for adjuvant treatment of surgically resected non-small cell lung cancer, a collaborative Project Orbis review.
    Clin Cancer Res. 2021 Jul 22. pii: 1078-0432.CCR-21-1034.
    PubMed     Abstract available


  88. CHANG JC, Offin M, Falcon C, Brown D, et al
    Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes.
    Clin Cancer Res. 2021;27:4066-4076.
    PubMed     Abstract available


  89. LUO J, Martucci VL, Quandt Z, Groha S, et al
    Immunotherapy-mediated thyroid dysfunction: genetic risk and impact on outcomes with PD-1 blockade in non-small cell lung cancer.
    Clin Cancer Res. 2021 Jul 8. pii: 1078-0432.CCR-21-0921.
    PubMed     Abstract available


  90. FOSTER JH, Voss SD, Hall DC, Minard CG, et al
    Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912).
    Clin Cancer Res. 2021;27:3543-3548.
    PubMed     Abstract available


    June 2021
  91. WEISS SA, Djureinovic D, Jessel S, Krykbaeva I, et al
    A phase I study of APX005M and cabiralizumab with/without nivolumab in patients with melanoma, kidney cancer or non-small cell lung cancer resistant to anti-PD-(L)1.
    Clin Cancer Res. 2021 Jun 17. pii: 1078-0432.CCR-21-0903.
    PubMed     Abstract available


  92. RAGHAV K, Hwang H, Jacome AA, Bhang E, et al
    Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary.
    Clin Cancer Res. 2021;27:3414-3421.
    PubMed     Abstract available


  93. GARON EB, Spira AI, Johnson M, Bazhenova L, et al
    A phase 1b open-label, multicenter study of inhaled DV281, a TLR9 agonist, in combination with nivolumab in patients with advanced or metastatic non-small cell lung cancer.
    Clin Cancer Res. 2021 Jun 9. pii: 1078-0432.CCR-21-0263.
    PubMed     Abstract available


  94. LEWIS CD, Singh AK, Hsu FF, Thotala D, et al
    Targeting a Radiosensitizing Antibody-Drug Conjugate to a Radiation-Inducible Antigen.
    Clin Cancer Res. 2021;27:3224-3233.
    PubMed     Abstract available


  95. COMPTE M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, et al
    An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity.
    Clin Cancer Res. 2021;27:3167-3177.
    PubMed     Abstract available


    May 2021
  96. KIM J, Bradford D, Larkins E, Pai-Scherf LH, et al
    FDA Approval Summary: Pralsetinib for the Treatment of Lung and Thyroid cancers with RET gene mutations or fusions.
    Clin Cancer Res. 2021 May 27. pii: 1078-0432.CCR-21-0967.
    PubMed     Abstract available


  97. CORTOT AB, Madroszyk-Flandin A, Giroux Leprieur E, Molinier O, et al
    First-line Afatinib plus Cetuximab for EGFR-mutant Non-small-cell Lung Cancer: Results from the Randomized Phase 2 IFCT-1503 ACE-Lung Study.
    Clin Cancer Res. 2021 May 24. pii: 1078-0432.CCR-20-4604.
    PubMed     Abstract available


  98. CHOUDHURY NJ, Schoenfeld AJ, Flynn J, Falcon CJ, et al
    Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions.
    Clin Cancer Res. 2021;27:2920-2927.
    PubMed     Abstract available


  99. BYERS LA, Bentsion D, Gans S, Penkov K, et al
    Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naive Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study.
    Clin Cancer Res. 2021 May 4. pii: 1078-0432.CCR-20-4259.
    PubMed     Abstract available


  100. JONES GD, Caso R, Tan KS, Mastrogiacomo B, et al
    KRAS (G12C) Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma.
    Clin Cancer Res. 2021;27:2604-2612.
    PubMed     Abstract available


    April 2021
  101. CHEN K, Nie Y, Park S, Zhang K, et al
    Development and Validation of Machine Learning-based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts.
    Clin Cancer Res. 2021;27:2255-2265.
    PubMed     Abstract available


  102. OEHL K, Vrugt B, Wagner U, Kirschner MB, et al
    Alterations in BAP1 Are Associated with Cisplatin Resistance through Inhibition of Apoptosis in Malignant Pleural Mesothelioma.
    Clin Cancer Res. 2021;27:2277-2291.
    PubMed     Abstract available


  103. DREYFUSS AD, Goia D, Shoniyozov K, Shewale SV, et al
    A Novel Mouse Model of Radiation-Induced Cardiac Injury Reveals Biological and Radiological Biomarkers of Cardiac Dysfunction with Potential Clinical Relevance.
    Clin Cancer Res. 2021;27:2266-2276.
    PubMed     Abstract available


  104. SHAFIQUE M, Fisher TL, Evans EE, Leonard JE, et al
    A Phase 1b/2 Study of Pepinemab in Combination with Avelumab in Advanced Non-Small Cell Lung Cancer.
    Clin Cancer Res. 2021 Apr 5. pii: 1078-0432.CCR-20-4792.
    PubMed     Abstract available


    March 2021
  105. BERTINO EM, Gentzler RD, Clifford S, Kolesar J, et al
    Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903).
    Clin Cancer Res. 2021;27:1604-1611.
    PubMed     Abstract available


  106. SI H, Kuziora M, Quinn KJ, Helman E, et al
    A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study.
    Clin Cancer Res. 2021;27:1631-1640.
    PubMed     Abstract available


  107. SITTHIDEATPHAIBOON P, Galan-Cobo A, Negrao MV, Qu X, et al
    STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.
    Clin Cancer Res. 2021;27:1720-1733.
    PubMed     Abstract available


  108. AGGARWAL C, Thompson JC, Carpenter EL
    Plasma Tumor Mutation Burden and Response to Pembrolizumab-Response.
    Clin Cancer Res. 2021;27:1581.
    PubMed    


  109. XUE Z, Guo X, Wen J, Cai W, et al
    Plasma Tumor Mutation Burden and Response to Pembrolizumab-Letter.
    Clin Cancer Res. 2021;27:1580.
    PubMed    


  110. ESTRADA-BERNAL A, Le AT, Doak AE, Tirunagaru VG, et al
    Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.
    Clin Cancer Res. 2021;27:1463-1475.
    PubMed     Abstract available


  111. HACKENG WM, Dreijerink KMA, de Leng WWJ, Morsink FHM, et al
    Genome Methylation Accurately Predicts Neuroendocrine Tumor Origin: An Online Tool.
    Clin Cancer Res. 2021;27:1341-1350.
    PubMed     Abstract available


  112. ZHOU C, Wang Y, Zhao J, Chen G, et al
    Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy.
    Clin Cancer Res. 2021;27:1296-1304.
    PubMed     Abstract available


  113. TANIMOTO A, Matsumoto S, Takeuchi S, Arai S, et al
    Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression.
    Clin Cancer Res. 2021;27:1410-1420.
    PubMed     Abstract available


    February 2021
  114. GARON EB
    Osimertinib plus Ramucirumab: The Best of Both Worlds?
    Clin Cancer Res. 2021;27:905-907.
    PubMed     Abstract available


  115. SKOULIDIS F
    Transcription Strikes Back: Clinical Utility of Lung Adenocarcinoma Subtypes.
    Clin Cancer Res. 2021;27:913-915.
    PubMed     Abstract available


  116. HELLMANN MD, Janne PA, Opyrchal M, Hafez N, et al
    Entinostat plus Pembrolizumab in Patients with Metastatic NSCLC Previously Treated with Anti-PD-(L)1 Therapy.
    Clin Cancer Res. 2021;27:1019-1028.
    PubMed     Abstract available


  117. TAN Y, Sementino E, Cheung M, Peri S, et al
    Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma.
    Clin Cancer Res. 2021;27:1200-1213.
    PubMed     Abstract available


  118. DAEMEN A, Cooper JE, Myrta S, Wongchenko MJ, et al
    Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma.
    Clin Cancer Res. 2021;27:1162-1173.
    PubMed     Abstract available


  119. AI X, Cui J, Zhang J, Chen R, et al
    Clonal Architecture of EGFR Mutation Predicts the Efficacy of EGFR-Tyrosine Kinase Inhibitors in Advanced NSCLC: A Prospective Multicenter Study (NCT03059641).
    Clin Cancer Res. 2021;27:704-712.
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  120. GUO R, Offin M, Brannon AR, Chang J, et al
    MET Exon 14-altered Lung Cancers and MET Inhibitor Resistance.
    Clin Cancer Res. 2021;27:799-806.
    PubMed     Abstract available


    January 2021
  121. RAHMA OE, Reuss JE, Giobbie-Hurder A, Shoja E Razavi G, et al
    Early 3+3 Trial Dose-Escalation Phase I Clinical Trial Design and Suitability for Immune Checkpoint Inhibitors.
    Clin Cancer Res. 2021;27:485-491.
    PubMed     Abstract available


  122. GEIGER T, Beck L, Harel M, Yu S, et al
    Clinical Proteomics of Metastatic Melanoma Reveals Profiles of Organ-Specificity and Treatment Resistance.
    Clin Cancer Res. 2021 Jan 14. pii: 1078-0432.CCR-20-3752.
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  123. DEUTSCH E, Chargari C, Weichselbaum RR, Levy A, et al
    Drug-Radiotherapy Combination Trial Developments-Response.
    Clin Cancer Res. 2021;27:356.
    PubMed    


  124. EVANS JR, Cuneo KC, Lawrence TS
    Drug-Radiotherapy Combination Trial Developments-Letter.
    Clin Cancer Res. 2021;27:355.
    PubMed    


  125. COLCLOUGH N, Chen K, Johnstrom P, Strittmatter N, et al
    Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs.
    Clin Cancer Res. 2021;27:189-201.
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    November 2020
  126. BRADFORD D, Larkins E, Mushti SL, Rodriguez L, et al
    FDA Approval Summary: Selpercatinib for the Treatment of Lung and Thyroid cancers with RET Gene Mutations or Fusions.
    Clin Cancer Res. 2020 Nov 25. pii: 1078-0432.CCR-20-3558.
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    April 2020
  127. EGUREN-SANTAMARIA I, Sanmamed MF, Goldberg SB, Kluger HM, et al
    PD-1/PD-L1 blockers in NSCLC brain metastases: challenging paradigms and clinical practice.
    Clin Cancer Res. 2020 Apr 30. pii: 1078-0432.CCR-20-0798.
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