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COVID Reference, 4th edition, 372 pages

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  Lung Cancer

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1 AJR Am J Roentgenol
1 Am J Clin Oncol
1 Am J Clin Pathol
1 Am J Pathol
3 Am J Respir Crit Care Med
1 Ann Oncol
7 Ann Thorac Surg
2 BMC Cancer
3 Cancer
1 Cancer Chemother Pharmacol
3 Cancer Lett
2 Cancer Res
6 Cancer Sci
3 Chest
1 Clin Cancer Res
3 Clin Lung Cancer
1 Clin Nucl Med
1 Eur J Cancer
1 Int J Cancer
1 Int J Oncol
1 Int J Radiat Oncol Biol Phys
1 J Cancer Res Clin Oncol
2 J Clin Oncol
2 J Surg Oncol
6 J Thorac Cardiovasc Surg
3 J Thorac Oncol
1 Lancet Oncol
1 Lancet Respir Med
10 Lung Cancer
1 Nat Genet
1 Nat Med
1 Oncogene
3 Oncologist
2 PLoS One
1 Thorax

  Retrieve available abstracts of this week’s articles:
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Single Articles

    AJR Am J Roentgenol

  1. LI Q, Li X, Li XY, Huo JW, et al
    Spectral CT in Lung Cancer: Usefulness of Iodine Concentration for Evaluation of Tumor Angiogenesis and Prognosis.
    AJR Am J Roentgenol. 2020 Jun 22:1-8. doi: 10.2214/AJR.19.22688.
    PubMed         Abstract available

    Am J Clin Oncol

  2. VIANI GA, Arruda CV, De Fendi LI
    Effectiveness and Safety of Reirradiation With Stereotactic Ablative Radiotherapy of Lung Cancer After a First Course of Thoracic Radiation: A Meta-analysis.
    Am J Clin Oncol. 2020 Jun 16. doi: 10.1097/COC.0000000000000709.
    PubMed         Abstract available

    Am J Clin Pathol

  3. HERNANDEZ A, Brandler TC, Chen F, Zhou F, et al
    Scoring of Programmed Death-Ligand 1 Immunohistochemistry on Cytology Cell Block Specimens in Non-Small Cell Lung Carcinoma.
    Am J Clin Pathol. 2020 Jun 26. pii: 5863169. doi: 10.1093.
    PubMed         Abstract available

    Am J Pathol

  4. PEI YF, He Y, Hu LZ, Zhou B, et al
    The Crosstalk between lncRNA-SNHG7/miRNA-181/cbx7 Modulates Malignant Character in Lung Adenocarcinoma.
    Am J Pathol. 2020;190:1343-1354.
    PubMed         Abstract available

    Am J Respir Crit Care Med

  5. QIAN J, Zhao S, Zou Y, Rahman SMJ, et al
    Genomic Underpinnings of Tumor Behavior in In Situ and Early Lung Adenocarcinoma.
    Am J Respir Crit Care Med. 2020;201:697-706.
    PubMed         Abstract available

  6. LIANG NC, Von Visger T, Devereaux A
    Mindfulness for those with COPD, Asthma, Lung Cancer and Lung Transplantation.
    Am J Respir Crit Care Med. 2020 Jun 22. doi: 10.1164/rccm.2020.

  7. CHERIAN SV, Gill BS, Irani AD, Estrada-Y-Martin RM, et al
    Empyema "Necessitated" by Indwelling Pleural Catheter: A Unique Complication.
    Am J Respir Crit Care Med. 2020;201:e17-e18.

    Ann Oncol

  8. LUO J, Rizvi H, Preeshagul IR, Egger JV, et al
    COVID-19 in patients with lung cancer.
    Ann Oncol. 2020 Jun 16. pii: S0923-7534(20)39894.
    PubMed         Abstract available

    Ann Thorac Surg

  9. TONG C, Li T, Huang C, Ji C, et al
    Risk Factors and Impact of Conversion to Thoracotomy From 20,565 Cases of Thoracoscopic Lung Surgery.
    Ann Thorac Surg. 2020;109:1522-1529.
    PubMed         Abstract available

  10. YANG CJ, Nwosu A, Mayne NR, Wang YY, et al
    A Minimally Invasive Approach to Lobectomy After Induction Therapy Does Not Compromise Survival.
    Ann Thorac Surg. 2020;109:1503-1511.
    PubMed         Abstract available

  11. PRENAFETA CLARAMUNT N, Hwang D, de Perrot M, Yasufuku K, et al
    Incidence of Ipsilateral Side Recurrence After Open or Video-Assisted Thoracic Surgery Resection of Colorectal Lung Metastases.
    Ann Thorac Surg. 2020;109:1591-1597.
    PubMed         Abstract available

  12. NAKAMURA A, Takuwa T, Hashimoto M, Kuroda A, et al
    Clinical Outcomes With Recurrence After Pleurectomy/Decortication for Malignant Pleural Mesothelioma.
    Ann Thorac Surg. 2020;109:1537-1543.
    PubMed         Abstract available

  13. MIMAE T, Tsutani Y, Miyata Y, Imai K, et al
    Solid Tumor Size of 2 cm Divides Outcomes of Patients With Mixed Ground Glass Opacity Lung Tumors.
    Ann Thorac Surg. 2020;109:1530-1536.
    PubMed         Abstract available

  14. STEILING K, Loui T, Asokan S, Nims S, et al
    Age, Race, and Income Are Associated With Lower Screening Rates at a Safety Net Hospital.
    Ann Thorac Surg. 2020;109:1544-1550.
    PubMed         Abstract available

  15. HSU PK, Chuang LC, Wu YC
    Electromagnetic Navigation-Guided Preoperative Localization of Small Malignant Pulmonary Tumors.
    Ann Thorac Surg. 2020;109:1566-1573.
    PubMed         Abstract available

    BMC Cancer

  16. MA F, Xie Y, Lei Y, Kuang Z, et al
    The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer.
    BMC Cancer. 2020;20:580.
    PubMed         Abstract available

  17. XU T, Zhang X, Zhang S, Liu C, et al
    Imaging features and prognostic value of (18)F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study.
    BMC Cancer. 2020;20:596.
    PubMed         Abstract available


  18. ALAHMADI A, Dowlati A
    Slicing and dicing small cell lung cancer to improve trial outcomes.
    Cancer. 2020 Jun 25. doi: 10.1002/cncr.33047.

  19. PARK S, Shim J, Mortimer PGS, Smith SA, et al
    Biomarker-driven phase 2 umbrella trial study for patients with recurrent small cell lung cancer failing platinum-based chemotherapy.
    Cancer. 2020 Jun 25. doi: 10.1002/cncr.33048.
    PubMed         Abstract available

  20. PRINTZ C
    New guidance for treating patients with lung cancer and COVID-19.
    Cancer. 2020;126:3173.

    Cancer Chemother Pharmacol

  21. FUKUMOTO SI, Oizumi S, Harada M, Sukoh N, et al
    A randomized phase II trial of cisplatin plus gemcitabine versus carboplatin plus gemcitabine in patients with completely resected non-small cell lung cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT0703).
    Cancer Chemother Pharmacol. 2020 Jun 20. pii: 10.1007/s00280-020-04104.
    PubMed         Abstract available

    Cancer Lett

  22. YIN H, Wang X, Zhang X, Zeng Y, et al
    UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation.
    Cancer Lett. 2020 Jun 23. pii: S0304-3835(20)30331.
    PubMed         Abstract available

  23. SEIDL C, Panzitt K, Bertsch A, Brcic L, et al
    MicroRNA-182-5p regulates hedgehog signaling pathway and chemosensitivity of cisplatin-resistant lung adenocarcinoma cells via targeting GLI2.
    Cancer Lett. 2020;469:266-276.
    PubMed         Abstract available

  24. ZHANG L, Zhang X, Liu Y, Zhang T, et al
    PD-L1(+) aneuploid circulating tumor endothelial cells (CTECs) exhibit resistance to the checkpoint blockade immunotherapy in advanced NSCLC patients.
    Cancer Lett. 2020;469:355-366.
    PubMed         Abstract available

    Cancer Res

  25. YANG YC, Pan KF, Lee WJ, Chang JH, et al
    Circulating proteoglycan endocan mediates EGFR-driven progression of non-small cell lung cancer.
    Cancer Res. 2020 Jun 19. pii: 0008-5472.CAN-20-0005.
    PubMed         Abstract available

  26. IKEMORI R, Gabasa M, Duch P, Vizoso M, et al
    Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma.
    Cancer Res. 2020;80:276-290.
    PubMed         Abstract available

    Cancer Sci

  27. ZHONG C, Chen C, Yao F, Fang W, et al
    ZNF251 promotes the progression of lung cancer by activating ERK signaling.
    Cancer Sci. 2020 Jun 26. doi: 10.1111/cas.14547.
    PubMed         Abstract available

  28. YONESHIMA Y, Kato K, Minami H, Ikeda M, et al
    HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors.
    Cancer Sci. 2020 Jun 18. doi: 10.1111/cas.14536.
    PubMed         Abstract available

  29. OKAZAKI Y, Chew SH, Nagai H, Yamashita Y, et al
    Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats.
    Cancer Sci. 2020;111:2016-2027.
    PubMed         Abstract available

  30. MATSUBARA D, Yoshimoto T, Soda M, Amano Y, et al
    Reciprocal expression of trefoil factor-1 and thyroid transcription factor-1 in lung adenocarcinomas.
    Cancer Sci. 2020;111:2183-2195.
    PubMed         Abstract available

  31. DU P, Hu T, An Z, Li P, et al
    In vitro and in vivo synergistic efficacy of ceritinib combined with programmed cell death ligand-1 inhibitor in anaplastic lymphoma kinase-rearranged non-small-cell lung cancer.
    Cancer Sci. 2020;111:1887-1898.
    PubMed         Abstract available

  32. HUANG J, Li J, Zheng S, Lu Z, et al
    Tumor microenvironment characterization identifies two lung adenocarcinoma subtypes with specific immune and metabolic state.
    Cancer Sci. 2020;111:1876-1886.
    PubMed         Abstract available


  33. URBANIA TH, Dusendang JR, Herrinton LJ, Alexeeff S, et al
    Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study.
    Chest. 2020 Jun 17. pii: S0012-3692(20)31677-9. doi: 10.1016/j.chest.2020.
    PubMed         Abstract available

  34. VRANAS KC, Lapidus JA, Ganzini L, Slatore CG, et al
    Association of Palliative Care Use and Setting with Healthcare Utilization and Quality of Care at the End of Life Among Patients with Advanced Lung Cancer.
    Chest. 2020 Jun 23. pii: S0012-3692(20)31721-9. doi: 10.1016/j.chest.2020.
    PubMed         Abstract available

  35. TAILOR TD, Tong BC, Gao J, Henderson LM, et al
    Utilization of Lung Cancer Screening in the Medicare Fee-for-Service Population.
    Chest. 2020 Jun 17. pii: S0012-3692(20)31674-3. doi: 10.1016/j.chest.2020.
    PubMed         Abstract available

    Clin Cancer Res

  36. HIPP S, Voynov V, Drobits-Handl B, Giragossian C, et al
    A Bispecific DLL3/CD3 IgG-like T-cell Antibody induces anti-tumor responses in Small Cell Lung Cancer.
    Clin Cancer Res. 2020 Jun 18. pii: 1078-0432.CCR-20-0926.
    PubMed         Abstract available

    Clin Lung Cancer

  37. CHIANG AC, Sequist LVD, Gilbert J, Conkling P, et al
    Clinical Activity and Safety of Atezolizumab in a Phase 1 Study of Patients With Relapsed/Refractory Small-Cell Lung Cancer.
    Clin Lung Cancer. 2020 May 12. pii: S1525-7304(20)30148.
    PubMed         Abstract available

  38. NAIDOO J, Nishino M, Patel SP, Shankar B, et al
    Immune-Related Pneumonitis After Chemoradiotherapy and Subsequent Immune Checkpoint Blockade in Unresectable Stage III Non-Small-Cell Lung Cancer.
    Clin Lung Cancer. 2020 Mar 9. pii: S1525-7304(20)30076.
    PubMed         Abstract available

  39. BALL S, Dash A, Igid HP, Thein KZ, et al
    Primary Extra-axial Chordoma Masquerading as Lung Cancer: Case Report and Review of the Literature.
    Clin Lung Cancer. 2020 May 11. pii: S1525-7304(20)30141.

    Clin Nucl Med

  40. KOBAYASHI SHIMIZU S, Okamura T, Koyama K, Seura H, et al
    A Case of Localized Malignant Peritoneal Mesothelioma With Lung Cancer Detected by 18F-FDG PET/CT.
    Clin Nucl Med. 2020 Jun 17. doi: 10.1097/RLU.0000000000003129.
    PubMed         Abstract available

    Eur J Cancer

  41. DU Y, Sidorenkov G, Heuvelmans MA, Groen HJM, et al
    Cost-effectiveness of lung cancer screening with low-dose computed tomography in heavy smokers: a microsimulation modelling study.
    Eur J Cancer. 2020;135:121-129.
    PubMed         Abstract available

    Int J Cancer

  42. WU D, Nie J, Hu W, Dai L, et al
    A phase II study of anlotinib in 45 patients with relapsed small cell lung cancer.
    Int J Cancer. 2020 Jun 18. doi: 10.1002/ijc.33161.
    PubMed         Abstract available

    Int J Oncol

  43. CHENG L, Gou L, Wei T, Zhang J, et al
    GBP1 promotes erlotinib resistance via PGK1activated EMT signaling in nonsmall cell lung cancer.
    Int J Oncol. 2020 Jun 22. doi: 10.3892/ijo.2020.5086.
    PubMed         Abstract available

    Int J Radiat Oncol Biol Phys

  44. GUCKENBERGER M, Belka C, Bezjak A, Bradley J, et al
    Practice Recommendations for Lung Cancer Radiotherapy During the COVID-19 Pandemic: An ESTRO-ASTRO Consensus Statement.
    Int J Radiat Oncol Biol Phys. 2020;107:631-640.
    PubMed         Abstract available

    J Cancer Res Clin Oncol

  45. KIM SH, Choi CM, Lee DH, Kim SW, et al
    Clinical outcomes of nivolumab in patients with advanced non-small cell lung cancer in real-world practice, with an emphasis on hyper-progressive disease.
    J Cancer Res Clin Oncol. 2020 Jun 24. pii: 10.1007/s00432-020-03293.
    PubMed         Abstract available

    J Clin Oncol

  46. TATEISHI A, Ishiki H, Kubo E, Satomi E, et al
    EMERGING-CTONG 1103: For Achieving High-Quality Evidence in a Randomized Phase II Trial.
    J Clin Oncol. 2020;38:285-286.

  47. WU YL, Zhong WZ, Yan HH
    Reply to A. Tateishi et al.
    J Clin Oncol. 2020;38:286-287.

    J Surg Oncol

  48. KAPETANAKIS EI, Filippiadis DK, Tomos IP, Karakatsani A, et al
    The role of percutaneous interventions in the management of lung cancer patients during the Covid-19 pandemic.
    J Surg Oncol. 2020 Jun 25. doi: 10.1002/jso.26084.

  49. BAUMANN BC, Bernstein KA, DeLaney TF, Simone CB, et al
    Multi-institutional analysis of stereotactic body radiotherapy for sarcoma pulmonary metastases: High rates of local control with favorable toxicity.
    J Surg Oncol. 2020 Jun 25. doi: 10.1002/jso.26078.
    PubMed         Abstract available

    J Thorac Cardiovasc Surg

  50. BURT BM, Lee HS, Raghuram AC, Strange C, et al
    Preoperative prediction of unresectability in malignant pleural mesothelioma.
    J Thorac Cardiovasc Surg. 2020;159:2512-2520.
    PubMed         Abstract available

  51. HYLTON DA, Turner S, Kidane B, Spicer J, et al
    The Canada Lymph Node Score for prediction of malignancy in mediastinal lymph nodes during endobronchial ultrasound.
    J Thorac Cardiovasc Surg. 2020;159:2499-2507.
    PubMed         Abstract available

  52. VIEIRA A, Bourdages-Pageau E, Kennedy K, Ugalde PA, et al
    The learning curve on uniportal video-assisted thoracic surgery: An analysis of proficiency.
    J Thorac Cardiovasc Surg. 2020;159:2487-2495.
    PubMed         Abstract available

  53. MOLINA JC, Chaudry F, Menezes V, Ferraro P, et al
    Transvascular endosonographic-guided needle biopsy of intrathoracic lesions.
    J Thorac Cardiovasc Surg. 2020;159:2057-2065.
    PubMed         Abstract available

  54. WAKEAM E, Adibfar A, Stokes S, Leighl NB, et al
    Defining the role of adjuvant therapy for early-stage large cell neuroendocrine carcinoma.
    J Thorac Cardiovasc Surg. 2020;159:2043-2054.
    PubMed         Abstract available

  55. JONES GD, Tan KS, Caso R, Dycoco J, et al
    Time-varying analysis of readmission and mortality during the first year after pneumonectomy.
    J Thorac Cardiovasc Surg. 2020;160:247-255.
    PubMed         Abstract available

    J Thorac Oncol

  56. SHUKUYA T, Ghai V, Amann JM, Okimoto T, et al
    Circulating miRNAs and extracellular vesicle containing miRNAs as response biomarkers of anti PD-1/PD-L1 therapy in non-small-cell lung cancer.
    J Thorac Oncol. 2020 Jun 18. pii: S1556-0864(20)30467.
    PubMed         Abstract available

  57. ABRAVAN A, Faivre-Finn C, Kennedy J, McWilliam A, et al
    Radiotherapy-related lymphopenia affects overall survival in patients with lung cancer.
    J Thorac Oncol. 2020 Jun 14. pii: S1556-0864(20)30478.
    PubMed         Abstract available

  58. RAY MA, Smeltzer MP, Faris N, Osarogiagbon RU, et al
    Survival after mediastinal node dissection, systematic sampling or neither for early-stage non-small-cell lung cancer.
    J Thorac Oncol. 2020 Jun 20. pii: S1556-0864(20)30479.
    PubMed         Abstract available

    Lancet Oncol

  59. DAS M
    Nelfinavir with concurrent chemoradiotherapy in NSCLC.
    Lancet Oncol. 2019 Aug 30. pii: S1470-2045(19)30567.

    Lancet Respir Med

    Next-generation ALK inhibitors: is the median the message?
    Lancet Respir Med. 2020;8:5-7.

    Lung Cancer

  61. KOBAYASHI K, Soejima K, Fukunaga K, Shintani Y, et al
    Key prognostic factors for EGFR-mutated non-adenocarcinoma lung cancer patients in the Japanese Joint Committee of Lung Cancer Registry Database.
    Lung Cancer. 2020;146:236-243.
    PubMed         Abstract available

  62. LIAO Z, Rivin Del Campo E, Salem A, Pang Q, et al
    Optimizing lung cancer radiation treatment worldwide in COVID-19 outbreak.
    Lung Cancer. 2020;146:230-235.
    PubMed         Abstract available

  63. WANG W, Cheng G, Zhang G, Song Z, et al
    Evaluation of a new diagnostic immunohistochemistry approach for ROS1 rearrangement in non-small cell lung cancer.
    Lung Cancer. 2020;146:224-229.
    PubMed         Abstract available

  64. STAHEL RA, Curioni-Fontecedro A, Rohrmann S, Dafni U, et al
    Survival outcome of non-small cell lung cancer patients: Comparing results between the database of the Comprehensive Cancer Center Zurich and the Epidemiological Cancer Registry Zurich and Zug.
    Lung Cancer. 2020;146:217-223.
    PubMed         Abstract available

  65. ZHENG J, Zhu Y, Sun K, Shen Q, et al
    Investigation on the prognostic impact of concurrent genomic alterations in crizotinib-treated EML4-ALK-rearranged advanced non-small cell lung cancer patients.
    Lung Cancer. 2020;146:209-216.
    PubMed         Abstract available

  66. FORNACON-WOOD I, Faivre-Finn C, O'Connor JPB, Price GJ, et al
    Radiomics as a personalized medicine tool in lung cancer: Separating the hope from the hype.
    Lung Cancer. 2020;146:197-208.
    PubMed         Abstract available

  67. TESSEMA M, Tassew DD, Yingling CM, Do K, et al
    Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients.
    Lung Cancer. 2020;146:189-196.
    PubMed         Abstract available

  68. ZENKE Y, Niho S, Umemura S, Ishihara M, et al
    Phase I/II study of carboplatin plus weekly nab-paclitaxel in patients aged >/=75 years with squamous-cell lung cancer: TORG1322.
    Lung Cancer. 2020;146:182-188.
    PubMed         Abstract available

  69. ZHAO D, Mambetsariev I, Li H, Chen C, et al
    Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors.
    Lung Cancer. 2020;146:174-181.
    PubMed         Abstract available

  70. ZHOU F, Zhao W, Chen X, Zhang J, et al
    Response to the combination of dabrafenib, trametinib and osimertinib in a patient with EGFR-mutant NSCLC harboring an acquired BRAF(V600E) mutation.
    Lung Cancer. 2020;139:219-220.

    Nat Genet

  71. SHIH DJH, Nayyar N, Bihun I, Dagogo-Jack I, et al
    Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma.
    Nat Genet. 2020;52:371-377.
    PubMed         Abstract available

    Nat Med

  72. LU Y, Xue J, Deng T, Zhou X, et al
    Publisher Correction: Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer.
    Nat Med. 2020 Jun 18. pii: 10.1038/s41591-020-0973.
    PubMed         Abstract available


  73. DIAS MM, Adamoski D, Dos Reis LM, Ascencao CFR, et al
    GLS2 is protumorigenic in breast cancers.
    Oncogene. 2020;39:690-702.
    PubMed         Abstract available


  74. NAKAMURA A, Tanaka H, Saito R, Suzuki A, et al
    Phase II Study of Low-Dose Afatinib Maintenance Treatment Among Patients with EGFR-Mutated Non-Small Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 1601 (NJLCG1601).
    Oncologist. 2020 Jun 19. doi: 10.1634/theoncologist.2020-0545.
    PubMed         Abstract available

  75. ITCHINS M, Lau B, Hudson AL, Westman H, et al
    ALK-Rearranged Non-Small Cell Lung Cancer in 2020: Real-World Triumphs in an Era of Multigeneration ALK-Inhibitor Sequencing Informed by Drug Resistance Profiling.
    Oncologist. 2020 Jun 18. doi: 10.1634/theoncologist.2020-0075.
    PubMed         Abstract available

  76. BONANNO L, Pavan A, Ferro A, Calvetti L, et al
    Clinical Impact of Plasma and Tissue Next-Generation Sequencing in Advanced Non-Small Cell Lung Cancer: A Real-World Experience.
    Oncologist. 2020 Jun 18. doi: 10.1634/theoncologist.2020-0148.
    PubMed         Abstract available

    PLoS One

  77. MU Q, Yu J, Griffin JI, Wu Y, et al
    Novel drug combination nanoparticles exhibit enhanced plasma exposure and dose-responsive effects on eliminating breast cancer lung metastasis.
    PLoS One. 2020;15:e0228557.
    PubMed         Abstract available

  78. TERAMOTO A, Tsukamoto T, Yamada A, Kiriyama Y, et al
    Deep learning approach to classification of lung cytological images: Two-step training using actual and synthesized images by progressive growing of generative adversarial networks.
    PLoS One. 2020;15:e0229951.
    PubMed         Abstract available


  79. SACHS E, Jackson V, Sartipy U
    Household disposable income and long-term survival after pulmonary resections for lung cancer.
    Thorax. 2020 Jun 20. pii: thoraxjnl-2019-214321.
    PubMed         Abstract available

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