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Multiple Sclerosis

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 37 articles: HTML format

Single Articles

November 2025
1. KAPNICK SM, Gosselin EA, Tsai SJ, Oakes RS, et al
   Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity.
   Proc Natl Acad Sci U S A. 2025;122:e2409563122.
   PubMed     Abstract available
   
   
   September 2025
2. MYKICKI N, Eble JA, Weighardt H, Gonnelli E, et al
   AhR signaling in skin-resident CD207(+) cells is involved in UV-B-induced amelioration of neuroinflammation.
   Proc Natl Acad Sci U S A. 2025;122:e2424009122.
   PubMed     Abstract available
   
   
   August 2025
3. NEMATULLAH M, Fatma M, Zhou G, Prajapati B, et al
   Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity.
   Proc Natl Acad Sci U S A. 2025;122:e2427052122.
   PubMed     Abstract available
   
   
   July 2025
4. SIMKA M
   Previous epidemiological studies support the idea of ileal microbiota triggering multiple sclerosis.
   Proc Natl Acad Sci U S A. 2025;122:e2514491122.
   PubMed    
   
   
   
5. JIANG Y, Liu Q, Stridh P, Kockum I, et al
   Multiomics integration prioritizes potential drug targets for multiple sclerosis.
   Proc Natl Acad Sci U S A. 2025;122:e2425537122.
   PubMed     Abstract available
   
   
   June 2025
6. ATKINSON KC, Desfor S, Feri M, Sekyi MT, et al
   Decreased mitochondrial activity in the demyelinating cerebellum of progressive multiple sclerosis and chronic EAE contributes to Purkinje cell loss.
   Proc Natl Acad Sci U S A. 2025;122:e2421806122.
   PubMed     Abstract available
   
   
   
7. 
   Editorial Expression of Concern for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
   Proc Natl Acad Sci U S A. 2025;122:e2512750122.
   PubMed    
   
   
   May 2025
8. JENSEN LT, Fugger L
   Immune perturbation by the ileal microbiota in multiple sclerosis.
   Proc Natl Acad Sci U S A. 2025;122:e2506777122.
   PubMed    
   
   
   
9. GUPTA S, Arnab S, Nguyen KL, Reed M, et al
   Sex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2 activation in a model of MS and CNP.
   Proc Natl Acad Sci U S A. 2025;122:e2426771122.
   PubMed     Abstract available
   
   
   
10. YOON H, Gerdes LA, Beigel F, Sun Y, et al
    Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.
    Proc Natl Acad Sci U S A. 2025;122:e2419689122.
    PubMed     Abstract available
    
    
    April 2025
11. MECHELLI R, Umeton R, Bellucci G, Bigi R, et al
    A disease-specific convergence of host and Epstein-Barr virus genetics in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2418783122.
    PubMed     Abstract available
    
    
    
12. HOU J, Magliozzi R, Chen Y, Wu J, et al
    Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination.
    Proc Natl Acad Sci U S A. 2025;122:e2426786122.
    PubMed     Abstract available
    
    
    
13. MOLITOR TP, Hayashi G, Lin MY, Dunn CJ, et al
    Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator.
    Proc Natl Acad Sci U S A. 2025;122:e2422172122.
    PubMed     Abstract available
    
    
    March 2025
14. ORR N, Steinman L
    Epstein-Barr virus and the immune microenvironment in multiple sclerosis: Insights from high-dimensional brain tissue imaging.
    Proc Natl Acad Sci U S A. 2025;122:e2425670122.
    PubMed     Abstract available
    
    
    
15. SATTARNEZHAD N, Kockum I, Thomas OG, Liu Y, et al
    Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls.
    Proc Natl Acad Sci U S A. 2025;122:e2424986122.
    PubMed     Abstract available
    
    
    
16. GHIMIRE S, Lehman PC, Aguilar Meza LS, Shahi SK, et al
    Specific microbial ratio in the gut microbiome is associated with multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2413953122.
    PubMed     Abstract available
    
    
    February 2025
17. RAD LM, Hughes KR, Wheeler SN, Decker JT, et al
    Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2409852122.
    PubMed     Abstract available
    
    
    December 2024
18. LANZ TV, Robinson WH
    Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles connects the two main risk factors of multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2420070121.
    PubMed    
    
    
    November 2024
19. OKAMOTO M, Kuratani A, Okuzaki D, Kamiyama N, et al
    IFN-gamma-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.
    Proc Natl Acad Sci U S A. 2024;121:e2401692121.
    PubMed     Abstract available
    
    
    October 2024
20. 
    Correction for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2420080121.
    PubMed    
    
    
    
21. DROSU N, Anderson M, Bilodeau PA, Nishiyama S, et al
    CD4 T cells restricted to DRB1*15:01 recognize two Epstein-Barr virus glycoproteins capable of intracellular antigen presentation.
    Proc Natl Acad Sci U S A. 2024;121:e2416097121.
    PubMed     Abstract available
    
    
    August 2024
22. DENEEN B
    Pipe dream: Remyelination therapy for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2414324121.
    PubMed    
    
    
    
23. ALAKHRAS NS, Zhang W, Barros N, Sharma A, et al
    An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation.
    Proc Natl Acad Sci U S A. 2024;121:e2400153121.
    PubMed     Abstract available
    
    
    
24. POON MM, Lorrain KI, Stebbins KJ, Edu GC, et al
    Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407974121.
    PubMed     Abstract available
    
    
    July 2024
25. NATARAJAN C, Le LHD, Gunasekaran M, Tracey KJ, et al
    Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2322577121.
    PubMed     Abstract available
    
    
    June 2024
26. RAKEBRANDT N, Yassini N, Kolz A, Schorer M, et al
    Innate acting memory Th1 cells modulate heterologous diseases.
    Proc Natl Acad Sci U S A. 2024;121:e2312837121.
    PubMed     Abstract available
    
    
    February 2024
27. ADAMS C, Manouchehrinia A, Quach HL, Quach DL, et al
    Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans.
    Proc Natl Acad Sci U S A. 2024;121:e2302259121.
    PubMed     Abstract available
    
    
    January 2024
28. SUTTER PA, Willis CM, Menoret A, Nicaise AM, et al
    Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses.
    Proc Natl Acad Sci U S A. 2024;121:e2306816121.
    PubMed     Abstract available
    
    
    
29. GOTTLIEB A, Pham HPT, Saltarrelli JG, Lindsey JW, et al
    Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells.
    Proc Natl Acad Sci U S A. 2024;121:e2315857121.
    PubMed     Abstract available
    
    
    November 2023
30. THOMANN AS, McQuade CA, Pinjusic K, Kolz A, et al
    A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity.
    Proc Natl Acad Sci U S A. 2023;120:e2300733120.
    PubMed     Abstract available
    
    
    September 2023
31. GRUCHOT J, Lewen I, Dietrich M, Reiche L, et al
    Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.
    Proc Natl Acad Sci U S A. 2023;120:e2308187120.
    PubMed     Abstract available
    
    
    
32. GARCIA CORRALES AV, Verberk SGS, Haidar M, Grajchen E, et al
    Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination.
    Proc Natl Acad Sci U S A. 2023;120:e2301030120.
    PubMed     Abstract available
    
    
    May 2023
33. CAVERZASI E, Papinutto N, Cordano C, Kirkish G, et al
    MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial.
    Proc Natl Acad Sci U S A. 2023;120:e2217635120.
    PubMed     Abstract available
    
    
    April 2023
34. KAPATE N, Dunne M, Kumbhojkar N, Prakash S, et al
    A backpack-based myeloid cell therapy for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2023;120:e2221535120.
    PubMed     Abstract available
    
    
    
35. GHAREGHANI M, Zibara K, Rivest S
    Melatonin and vitamin D, two sides of the same coin, better to land on its edge to improve multiple sclerosis.
    Proc Natl Acad Sci U S A. 2023;120:e2219334120.
    PubMed     Abstract available
    
    
    March 2023
36. MADER S, Ho S, Wong HK, Baier S, et al
    Dissection of complement and Fc-receptor-mediated pathomechanisms of autoantibodies to myelin oligodendrocyte glycoprotein.
    Proc Natl Acad Sci U S A. 2023;120:e2300648120.
    PubMed     Abstract available
    
    
    March 2021
37. RONIN E, Pouchy C, Khosravi M, Hilaire M, et al
    Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells.
    Proc Natl Acad Sci U S A. 2021;118:e2014043118.
    PubMed     Abstract available
    
    

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