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  Obesity

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Articles published in Diabetes

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Single Articles


    May 2025
  1. ALBIERO M, Migliozzi L, Boscaro C, Rodella A, et al
    Padi4-Dependent NETosis Enables Diet-Induced Gut Hyperpermeability, Translating Dysbiosis Into Systemic Inflammation and Dysmetabolism.
    Diabetes. 2025;74:705-719.
    PubMed     Abstract available


    April 2025
  2. ODOEMELAM CS, Naz A, Thanaj M, Sorokin EP, et al
    Identifying four obesity axes through integrative multi-omics and imaging analysis.
    Diabetes. 2025 Apr 24:db241103. doi: 10.2337/db24-1103.
    PubMed     Abstract available


    March 2025
  3. KOHDA H, Tanaka M, Shichino S, Arakawa S, et al
    Novel cell-to-cell communications between macrophages and fibroblasts regulate obesity-induced adipose tissue fibrosis.
    Diabetes. 2025 Mar 10:db240762. doi: 10.2337/db24-0762.
    PubMed     Abstract available


  4. CIFARELLI V, Smith GI, Gonzalez-Nieves S, Samovski D, et al
    Adipose Tissue Biology and Effect of Weight Loss in Women With Lipedema.
    Diabetes. 2025;74:308-319.
    PubMed     Abstract available


  5. QIU C, Lu Y, Wu S, Guo W, et al
    Blocking Adipocyte YY1 Decouples Thermogenesis From Beneficial Metabolism by Promoting Spermidine Production.
    Diabetes. 2025;74:295-307.
    PubMed     Abstract available


    February 2025
  6. XIE QY, Granato A, Wong A, Yau C, et al
    Metabolic dysfunction associated with alterations in gut microbiota in adolescents with obesity.
    Diabetes. 2025 Feb 21:db240866. doi: 10.2337/db24-0866.
    PubMed     Abstract available


    January 2025
  7. D'ALESSIO DA, Kahn SE
    The Development of Glucagon-Like Peptide 1 as a Therapeutic: The Triumph of the Lasker Award for Obesity Is a Victory for Diabetes Research.
    Diabetes. 2025;74:1-3.
    PubMed    


    December 2024
  8. LIM CGY, Ozkan B, Liang Y, Chen J, et al
    Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population.
    Diabetes. 2024 Dec 2:db240184. doi: 10.2337/db24-0184.
    PubMed     Abstract available


  9. SCHLEH MW, Ameka MK, Rodriguez AS, Hasty AH, et al
    Deficiency of the Hemoglobin-Haptoglobin Receptor, CD163, Worsens Insulin Sensitivity in Obese Male Mice.
    Diabetes. 2024;73:1990-2002.
    PubMed     Abstract available


  10. LOH NY, Rosoff DB, Richmond R, Noordam R, et al
    Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits.
    Diabetes. 2024;73:2084-2094.
    PubMed     Abstract available


  11. MIYAMORI H, Yokokawa T, Miyakita M, Ozaki K, et al
    CRTC1 in Mc4r-Expressing Cells Is Required for Peripheral Metabolism and Systemic Energy Homeostasis.
    Diabetes. 2024;73:1976-1989.
    PubMed     Abstract available


    November 2024
  12. HARNOIS-LEBLANC S, Hivert MF
    Stopping the intergenerational risk of diabetes - from mechanisms to interventions.
    Diabetes. 2024 Nov 18:dbi240014. doi: 10.2337/dbi24-0014.
    PubMed     Abstract available


  13. ZHANG Y, Qian B, Yang Y, Niu F, et al
    Visceral Adipocyte-Derived Extracellular Vesicle miR-27a-5p Elicits Glucose Intolerance by Inhibiting Pancreatic beta-Cell Insulin Secretion.
    Diabetes. 2024;73:1832-1847.
    PubMed     Abstract available


  14. EID SA, Elzinga SE, Kim B, Rumora AE, et al
    High-Intensity Interval Training, Caloric Restriction, or Their Combination Have Beneficial Effects on Metabolically Acquired Peripheral Neuropathy.
    Diabetes. 2024;73:1895-1907.
    PubMed     Abstract available


    October 2024
  15. PAGE KA
    Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes.
    Diabetes. 2024 Oct 21:dbi240012. doi: 10.2337/dbi24-0012.
    PubMed     Abstract available


  16. FLAK JN
    Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes.
    Diabetes. 2024 Oct 17:dbi240011. doi: 10.2337/dbi24-0011.
    PubMed     Abstract available


  17. TOWNSEND KL
    One Nervous System: Critical Links Between Central and Peripheral Nervous System Health and Implications for Obesity and Diabetes.
    Diabetes. 2024 Oct 14:dbi240004. doi: 10.2337/dbi24-0004.
    PubMed    


    September 2024
  18. PARK CB, Lee CH, Cho KW, Shin S, et al
    Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity.
    Diabetes. 2024 Sep 20:db240097. doi: 10.2337/db24-0097.
    PubMed     Abstract available


  19. PETERSEN MC, Yoshino M, Smith GI, Gaspar RC, et al
    Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People with Obesity and Type 2 Diabetes.
    Diabetes. 2024 Sep 12:db240083. doi: 10.2337/db24-0083.
    PubMed     Abstract available


  20. USSHER JR, Aasum E
    The Relationship Between Cardiac Energy Metabolism and Cardiac Function in Obesity and Type 2 Diabetes: Revisiting a 2003 Diabetes Classic by Aasum et al.
    Diabetes. 2024;73:1373-1376.
    PubMed    


    August 2024
  21. CHEN X, Ruiz-Velasco A, Zou Z, Hille SS, et al
    PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
    Diabetes. 2024 Aug 13:db240240. doi: 10.2337/db24-0240.
    PubMed     Abstract available


    July 2024
  22. LUONG TV, Pedersen MGB, Abild CB, Lauritsen KM, et al
    A three-week ketogenic diet increases skeletal muscle insulin sensitivity in individuals with obesity - a randomized, controlled crossover trial.
    Diabetes. 2024 Jul 25:db240162. doi: 10.2337/db24-0162.
    PubMed     Abstract available


  23. KJELDSEN SAS, Richter MM, Jensen NJ, Nilsson MSD, et al
    Glucagon resistance in individuals with obesity and hepatic steatosis can be measured using the GLUSENTIC test and index.
    Diabetes. 2024 Jul 8:db230858. doi: 10.2337/db23-0858.
    PubMed     Abstract available


  24. DELLA PEPA G, Patricio BG, Carli F, Sabatini S, et al
    GLP-1 receptor agonist treatment improved fasting and postprandial lipidomic profile independently of diabetes and weight loss.
    Diabetes. 2024 Jul 8:db230972. doi: 10.2337/db23-0972.
    PubMed     Abstract available


  25. PARK S, Cha HN, Shin MG, Park S, et al
    Inhibitory Regulation of FOXO1 in PPARdelta Expression Drives Mitochondrial Dysfunction and Insulin Resistance.
    Diabetes. 2024;73:1084-1098.
    PubMed     Abstract available


    June 2024
  26. MITTENDORFER B, Johnson JD, Solinas G, Jansson PA, et al
    Insulin Hypersecretion as Promoter of Body Fat Gain and Hyperglycemia.
    Diabetes. 2024;73:837-843.
    PubMed    


  27. PESCHARD S, Raverdy V, Bauvin P, Goutchtat R, et al
    Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study.
    Diabetes. 2024;73:983-992.
    PubMed     Abstract available


    May 2024
  28. FISHER C, Johnson K, Moore M, Sadrati A, et al
    Loss of ATP-sensitive potassium channel expression and function in the nervous system decreases opioid sensitivity in high-fat-diet-fed mouse model of diet-induced obesity.
    Diabetes. 2024 May 22:db231030. doi: 10.2337/db23-1030.
    PubMed     Abstract available


  29. DIAMOND C, Pansini M, Hamid A, Eichert N, et al
    Quantitative imaging reveals steatosis and fibro-inflammation in multiple organs in people with type 2 diabetes: a real-world study.
    Diabetes. 2024 May 14:db230926. doi: 10.2337/db23-0926.
    PubMed     Abstract available


  30. SHEN KC, Collins KH, Ferey JLA, Fappi A, et al
    Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People with Metabolically Abnormal Obesity.
    Diabetes. 2024 May 3:db230991. doi: 10.2337/db23-0991.
    PubMed     Abstract available


  31. CHOUCAIR I, Mallela DP, Hilser JR, Hartiala JA, et al
    Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices.
    Diabetes. 2024 May 3:db230676. doi: 10.2337/db23-0676.
    PubMed     Abstract available


  32. GUPTA OT, Gupta RK
    The Expanding Problem of Regional Adiposity: Revisiting a 1985 Diabetes Classic by Ohlson et al.
    Diabetes. 2024;73:649-652.
    PubMed     Abstract available


  33. LEE SH, Suh JH, Heo MJ, Choi JM, et al
    The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects of Bile Acids.
    Diabetes. 2024;73:701-712.
    PubMed     Abstract available


    April 2024
  34. SMEEHUIJZEN L, Gijbels A, Nugteren-Boogaard JP, Vrieling F, et al
    Immunometabolic Signatures of Circulating Monocytes in Humans with Obesity and Insulin Resistance.
    Diabetes. 2024 Apr 24:db230970. doi: 10.2337/db23-0970.
    PubMed     Abstract available


  35. LIU J, Aylor KW, Liu Z
    Erratum. Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-Induced Obesity. Diabetes 2023;72:918-931.
    Diabetes. 2024 Apr 23:db24er07a. doi: 10.2337.
    PubMed     Abstract available


  36. PURNELL JQ
    Metabolic-Bariatric Surgery for Type 2 Diabetes: Time(ing) for a Change.
    Diabetes. 2024;73:542-544.
    PubMed    


    March 2024
  37. ABRAHAM A, Cule M, Thanaj M, Basty N, et al
    Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine.
    Diabetes. 2024 Mar 26:db231005. doi: 10.2337/db23-1005.
    PubMed     Abstract available


  38. FAN Y, Chow E, Lim CKP, Hou Y, et al
    Comparison of beta-cell function and insulin sensitivity between normal-weight and obese Chinese with young-onset type 2 diabetes.
    Diabetes. 2024 Mar 20:db230966. doi: 10.2337/db23-0966.
    PubMed     Abstract available


  39. RAMSHANKAR G, Perry RJ
    A New Mitochondrial Uncoupler Improves Metabolic Homeostasis in Mice.
    Diabetes. 2024;73:357-358.
    PubMed    


  40. RIERA CE
    Wiring the Brain for Wellness: Sensory Integration in Feeding and Thermogenesis: A Report on Research Supported by Pathway to Stop Diabetes.
    Diabetes. 2024;73:338-347.
    PubMed     Abstract available


    February 2024
  41. LI X, Su Y, Xu Y, Hu T, et al
    Adipocyte-specific Hnrnpa1 knockout aggravates obesity-induced metabolic dysfunction via upregulating of CCL2.
    Diabetes. 2024 Feb 6:db230609. doi: 10.2337/db23-0609.
    PubMed     Abstract available


  42. GILANI A, Stoll L, Homan EA, Lo JC, et al
    Adipose Signals Regulating Distal Organ Health and Disease.
    Diabetes. 2024;73:169-177.
    PubMed     Abstract available


  43. VALI A, Dalle H, Loubaresse A, Gilleron J, et al
    Adipocyte Glucocorticoid Receptor Activation With High Glucocorticoid Doses Impairs Healthy Adipose Tissue Expansion by Repressing Angiogenesis.
    Diabetes. 2024;73:211-224.
    PubMed     Abstract available


  44. HUANG J, Zhang Y, Zhou X, Song J, et al
    Foxj3 Regulates Thermogenesis of Brown and Beige Fat Via Induction of PGC-1alpha.
    Diabetes. 2024;73:178-196.
    PubMed     Abstract available


  45. ZHAO S, Li N, Xiong W, Li G, et al
    Leptin Reduction as a Required Component for Weight Loss.
    Diabetes. 2024;73:197-210.
    PubMed     Abstract available


  46. FURBER EC, Hyatt K, Collins K, Yu X, et al
    GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
    Diabetes. 2024;73:292-305.
    PubMed     Abstract available


    January 2024
  47. BACHA F, El-Ayash H, Mohamad M, Sharma S, et al
    Distinct Amino Acid Profile Characterizes Youth with or at risk for Type 2 Diabetes.
    Diabetes. 2024 Jan 12:db230375. doi: 10.2337/db23-0375.
    PubMed     Abstract available


  48. PURVIS GSD, Collino M, van Dam AD, Einaudi G, et al
    OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity.
    Diabetes. 2024 Jan 8:db220275. doi: 10.2337/db22-0275.
    PubMed     Abstract available


  49. HUANG M, Prasad RB, Coral DE, Hjort L, et al
    Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function.
    Diabetes. 2024 Jan 8:db230531. doi: 10.2337/db23-0531.
    PubMed     Abstract available


  50. WANG D, Jabile MJT, Lu J, Townsend LK, et al
    Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.
    Diabetes. 2024;73:51-56.
    PubMed     Abstract available


    December 2023
  51. LUK CT, Chan CK, Chiu F, Shi SY, et al
    Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
    Diabetes. 2023;72:1751-1765.
    PubMed     Abstract available


    November 2023
  52. KELLER MP, O'Connor C, Bitzer M, Schueler KL, et al
    Genetic analysis of obesity-induced diabetic nephropathy in BTBR mice.
    Diabetes. 2023 Nov 7:db230444. doi: 10.2337/db23-0444.
    PubMed     Abstract available


  53. BROTMAN SM, Oravilahti A, Rosen JD, Alvarez M, et al
    Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits.
    Diabetes. 2023;72:1707-1718.
    PubMed     Abstract available


  54. HUANG Y, Hertzel AV, Fish SR, Halley CL, et al
    TP53/p53 Facilitates Stress-Induced Exosome and Protein Secretion by Adipocytes.
    Diabetes. 2023;72:1560-1573.
    PubMed     Abstract available


    October 2023
  55. WRIGHT JJ, Eskaros A, Windon A, Bottino R, et al
    Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity.
    Diabetes. 2023 Oct 26:db230009. doi: 10.2337/db23-0009.
    PubMed     Abstract available


  56. MASHAYEKHI M, Nian H, Mayfield D, Devin JK, et al
    Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals with Obesity and Pre-Diabetes.
    Diabetes. 2023 Oct 24:db230356. doi: 10.2337/db23-0356.
    PubMed     Abstract available


  57. BERETTA M, Dai Y, Olzomer EM, Vancuylenburg CS, et al
    Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice.
    Diabetes. 2023 Oct 23:db230233. doi: 10.2337/db23-0233.
    PubMed     Abstract available


  58. TRICO D, Chiriaco M, Nouws J, Vash-Margita A, et al
    Alterations in adipose tissue distribution, cell morphology and function mark primary insulin hypersecretion in youths with obesity.
    Diabetes. 2023 Oct 23:db230450. doi: 10.2337/db23-0450.
    PubMed     Abstract available


  59. BONET ML, Ribot J, Pico C
    Decoding the Mechanisms Behind Early Weaning-Driven Obesity and the Leucine "Solution".
    Diabetes. 2023;72:1347-1349.
    PubMed    


    September 2023
  60. FELIX JF, Grant SFA
    Keeping It in the Family: Consanguinity Reveals P4HTM as a Novel Syndromic Obesity Gene.
    Diabetes. 2023;72:1184-1186.
    PubMed    


  61. PAN Q, Ai W, Chen Y, Kim DM, et al
    Reciprocal Regulation of Hepatic TGF-beta1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure.
    Diabetes. 2023;72:1193-1206.
    PubMed     Abstract available


    August 2023
  62. DENG Y, Liu X, Xie M, Zhao R, et al
    Obesity enables NLRP3 activation and induces myocardial fibrosis via hyperacetylation of HADHa.
    Diabetes. 2023 Aug 25:db230264. doi: 10.2337/db23-0264.
    PubMed     Abstract available


  63. ZHONG Y, Wang Y, Li X, Qin H, et al
    PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARgamma.
    Diabetes. 2023;72:1095-1111.
    PubMed     Abstract available


    July 2023
  64. CHRISTIANSEN MR, Kilpelainen TO, Mccaffery JM
    Abdominal obesity genetic variants predict waist circumference regain after weight loss.
    Diabetes. 2023 Jul 26:db230131. doi: 10.2337/db23-0131.
    PubMed     Abstract available


  65. ZARINI S, Zemski Berry KA, Kahn DE, Garfield A, et al
    Deoxysphingolipids: Atypical Skeletal Muscle Lipids Related to Insulin Resistance in Humans That Decrease Insulin Sensitivity In Vitro.
    Diabetes. 2023;72:884-897.
    PubMed     Abstract available


  66. PETRICK HL, Ogilvie LM, Brunetta HS, Robinson A, et al
    Dietary Nitrate and Corresponding Gut Microbiota Prevent Cardiac Dysfunction in Obese Mice.
    Diabetes. 2023;72:844-856.
    PubMed     Abstract available


    June 2023
  67. CHEN YC, Taylor AJ, Fulcher JM, Swensen AC, et al
    Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing but does not lead to spontaneous development of diabetes in mice.
    Diabetes. 2023 Jun 26:db220945. doi: 10.2337/db22-0945.
    PubMed     Abstract available


    May 2023
  68. ZENG L, Herdman DS, Lee SM, Tao A, et al
    Loss of cAMP signaling in CD11c immune cells protects against diet-induced obesity.
    Diabetes. 2023 May 31:db221035. doi: 10.2337/db22-1035.
    PubMed     Abstract available


  69. HUANG X, Zhao Y, Liu T, Wu D, et al
    beta-cell function and insulin dynamics in obese patients with and without diabetes after sleeve gastrectomy.
    Diabetes. 2023 May 31:db221048. doi: 10.2337/db22-1048.
    PubMed     Abstract available


  70. XIE R, Yan S, Zhou X, Gao Y, et al
    Activation of METTL3 promotes white adipose tissue beiging and combats obesity.
    Diabetes. 2023 May 24:db220775. doi: 10.2337/db22-0775.
    PubMed     Abstract available


  71. NGUYEN A, Khafagy R, Gao Y, Meerasa A, et al
    Erratum. Association Between Obesity and Chronic Kidney Disease: Multivariable Mendelian Randomization Analysis and Observational Data From a Bariatric Surgery Cohort. Diabetes 2023;72:496-510.
    Diabetes. 2023 May 18:db23er08a. doi: 10.2337.
    PubMed     Abstract available


  72. SUN Y, Sun B, Han X, Shan A, et al
    Leucine supplementation ameliorates early life "programming" of obesity in rats.
    Diabetes. 2023 May 17:db220862. doi: 10.2337/db22-0862.
    PubMed     Abstract available


  73. REYNOLDS GP
    Comment on Tabatabaei Dakhili et al. The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase. Diabetes 2023;72:126-134.
    Diabetes. 2023;72:e5.
    PubMed    


    April 2023
  74. SAEED S, Ning L, Badreddine A, Mirza MU, et al
    Biallelic mutations in P4HTM cause syndromic obesity.
    Diabetes. 2023 Apr 21:db221017. doi: 10.2337/db22-1017.
    PubMed     Abstract available


  75. LIU J, Aylor KW, Liu Z
    Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity.
    Diabetes. 2023 Apr 19:db220745. doi: 10.2337/db22-0745.
    PubMed     Abstract available


  76. LIU C, Meng M, Xu B, Xu Y, et al
    Fibroblast Growth Factor 6 Promotes Adipocyte Progenitor Cell Proliferation for Adipose Tissue Homeostasis.
    Diabetes. 2023;72:467-482.
    PubMed     Abstract available


    March 2023
  77. VIDMAR AP, Durazo-Arvizu R, Weigensberg MJ, Alderete TL, et al
    Rapid Decline in Beta-Cell Function and Increasing Adiposity is Associated with Conversion to Type 2 Diabetes in at Risk Latino Youth.
    Diabetes. 2023 Mar 27:db221034. doi: 10.2337/db22-1034.
    PubMed     Abstract available


  78. LUAN D, Dadpey B, Zaid J, Bridge-Comer PE, et al
    Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.
    Diabetes. 2023;72:367-374.
    PubMed     Abstract available


  79. ANDERSSON DP, Kerr AG, Dahlman I, Ryden M, et al
    Relationship Between a Sedentary Lifestyle and Adipose Insulin Resistance.
    Diabetes. 2023;72:316-325.
    PubMed     Abstract available


    January 2023
  80. CHEN ZZ, Gao Y, Keyes MJ, Deng S, et al
    Protein Markers of Diabetes Discovered in an African American Cohort.
    Diabetes. 2023 Jan 11:db220710. doi: 10.2337/db22-0710.
    PubMed     Abstract available


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