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  Obesity

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Articles published in Metabolism

Retrieve available abstracts of 83 articles:
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Single Articles


    August 2025
  1. ZHANG XD, Zhong YS, Yan H, Jin LH, et al
    Chemical discovery of a novel MD2/ADAM17 dual-target inhibitor as a potential therapeutic candidate for saturated fatty acid-induced myocardial inflammatory injury.
    Metabolism. 2025;169:156298.
    PubMed     Abstract available


  2. LEE YH, Lee J, Jeong J, Park K, et al
    Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1.
    Metabolism. 2025;169:156266.
    PubMed     Abstract available


    June 2025
  3. KATSAROU A, Papadopoulos G, Moustakas II, Papadopetraki A, et al
    Exercise mitigates liver senescence but does not outmatch dietary restriction in obesity-related MASLD.
    Metabolism. 2025 Jun 10:156325. doi: 10.1016/j.metabol.2025.156325.
    PubMed     Abstract available


  4. HINDSO M, Lundsgaard A, Marinkovic B, Jensen MH, et al
    Fat absorption and metabolism after Roux-en-Y gastric bypass surgery.
    Metabolism. 2025;167:156189.
    PubMed     Abstract available


    May 2025
  5. GALAN A, Garcia-Garcia F
    Revisiting gender differences in obesity and type 2 diabetes: Response letter.
    Metabolism. 2025 May 29:156307. doi: 10.1016/j.metabol.2025.156307.
    PubMed    


  6. SON YL, Hou J, Kato-Suzuki M, Okamatsu-Ogura Y, et al
    Corrigendum to "Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction" [Metabolism 168 (2025) 156235].
    Metabolism. 2025;170:156299.
    PubMed    


  7. ZHU H, Yi X, He M, Wu S, et al
    Exploring the interplay of genetic variants and environmental factors in childhood obesity: A systematic review and meta-analysis.
    Metabolism. 2025;170:156303.
    PubMed     Abstract available


    April 2025
  8. LENG S, Zhang X, Zhao R, Jiang N, et al
    Mechanical activation of adipose tissue macrophages mediated by Piezo1 protects against diet-induced obesity by regulating sympathetic activity.
    Metabolism. 2025 Apr 7:156262. doi: 10.1016/j.metabol.2025.156262.
    PubMed     Abstract available


  9. ZHONG Y, Wei J, Jiang R
    Revisiting gender differences in obesity and type 2 diabetes: Letter to the editor.
    Metabolism. 2025 Apr 3:156260. doi: 10.1016/j.metabol.2025.156260.
    PubMed    


    March 2025
  10. MOLDOVAN RA, Hidalgo MR, Castane H, Jimenez-Franco A, et al
    Landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue: a systematic review and meta-analysis of transcriptomics studies.
    Metabolism. 2025 Mar 27:156241. doi: 10.1016/j.metabol.2025.156241.
    PubMed     Abstract available


  11. RIBAS-LATRE A, Hoffmann A, Gebhardt C, Weiner J, et al
    The serine protease KLK7 promotes immune cell infiltration in visceral adipose tissue in obesity.
    Metabolism. 2025;168:156239.
    PubMed     Abstract available


  12. SON YL, Hou J, Kato-Suzuki M, Okamatsu-Ogura Y, et al
    Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction.
    Metabolism. 2025 Mar 19:156235. doi: 10.1016/j.metabol.2025.156235.
    PubMed     Abstract available


  13. ZHANG T, Ren Z, Mao R, Yi W, et al
    LINC00278 and BRG1: A key regulatory axis in male obesity and preadipocyte adipogenesis.
    Metabolism. 2025 Mar 17:156194. doi: 10.1016/j.metabol.2025.156194.
    PubMed     Abstract available


  14. KARAKASIS P, Patoulias D, Fragakis N, Mantzoros CS, et al
    Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis.
    Metabolism. 2025;164:156113.
    PubMed     Abstract available


  15. ZENG X, Wang Y, Farias K, Rappa A, et al
    NRH, a potent NAD(+) enhancer, improves glucose homeostasis and lipid metabolism in diet-induced obese mice through an active adenosine kinase pathway.
    Metabolism. 2025;164:156110.
    PubMed     Abstract available


    January 2025
  16. HU Y, Hai J, Ti Y, Kong B, et al
    Adipose ZFP36 protects against diet-induced obesity and insulin resistance.
    Metabolism. 2025;164:156131.
    PubMed     Abstract available


  17. HE Y, Zhang C, Wu S, Li K, et al
    Central NUCB2/nesfatin-1 signaling ameliorates liver steatosis through suppression of endoplasmic reticulum stress in the hypothalamus.
    Metabolism. 2025;162:156046.
    PubMed     Abstract available


    December 2024
  18. MELA V, Martin-Reyes F, Oliva-Olivera W, Cantarero-Cuenca A, et al
    Serum miR-365b-5p/miR-222-5p as a potential diagnostic biomarker for long-term weight loss in patients with morbid obesity after bariatric surgery.
    Metabolism. 2024 Dec 30:156129. doi: 10.1016/j.metabol.2024.156129.
    PubMed     Abstract available


  19. PERAKAKIS N, Mantzoros CS
    Evidence from clinical studies of leptin: current and future clinical applications in humans.
    Metabolism. 2024;161:156053.
    PubMed     Abstract available


  20. STEFANAKIS K, Kokkorakis M, Mantzoros CS
    The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation.
    Metabolism. 2024;161:156057.
    PubMed     Abstract available


  21. MUNZBERG H, Heymsfield SB, Berthoud HR, Morrison CD, et al
    History and future of leptin: Discovery, regulation and signaling.
    Metabolism. 2024;161:156026.
    PubMed     Abstract available


    November 2024
  22. BUCHWALD LM, Neess D, Hansen D, Doktor TK, et al
    Body weight control via protein kinase CK2: diet-induced obesity counteracted by pharmacological targeting.
    Metabolism. 2024;162:156060.
    PubMed     Abstract available


  23. ZHANG H, Zhou XD, Shapiro MD, Lip GYH, et al
    Global burden of metabolic diseases, 1990-2021.
    Metabolism. 2024;160:155999.
    PubMed     Abstract available


    October 2024
  24. CONFORTO R, Rizzo V, Russo R, Mazza E, et al
    Advances in body composition and gender differences in susceptibility to frailty syndrome: Role of osteosarcopenic obesity.
    Metabolism. 2024 Oct 26:156052. doi: 10.1016/j.metabol.2024.156052.
    PubMed     Abstract available


  25. SERRANO J, Kondo S, Link GM, Brown IS, et al
    A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study.
    Metabolism. 2024 Oct 9:156045. doi: 10.1016/j.metabol.2024.156045.
    PubMed     Abstract available


    September 2024
  26. XIE Z, Zheng G, Liang Z, Li M, et al
    Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss in patients with obesity or overweight: an updated systematic review and network meta-analysis of randomized controlled trials.
    Metabolism. 2024 Sep 19:156038. doi: 10.1016/j.metabol.2024.156038.
    PubMed     Abstract available


  27. BAGHERI M, Tanriverdi K, Iafrati MD, Mosley JD, et al
    Characterization of the plasma metabolome and lipidome in response to sleeve gastrectomy and gastric bypass surgeries reveals molecular patterns of surgical weight loss.
    Metabolism. 2024;158:155955.
    PubMed     Abstract available


    August 2024
  28. LIM JH, Kim Y, Kim MY, Kim EN, et al
    Placental growth factor deficiency initiates obesity- and aging-associated metabolic syndrome.
    Metabolism. 2024 Aug 20:156002. doi: 10.1016/j.metabol.2024.156002.
    PubMed     Abstract available


    July 2024
  29. RICHTER MM, Kemp IM, Heeboll S, Winther-Sorensen M, et al
    Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms.
    Metabolism. 2024;156:155915.
    PubMed     Abstract available


    June 2024
  30. JOLLET M, Tramontana F, Jiang LQ, Borg ML, et al
    Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity.
    Metabolism. 2024 Jun 4:155939. doi: 10.1016/j.metabol.2024.155939.
    PubMed     Abstract available


    May 2024
  31. HUTTASCH M, Roden M, Kahl S
    Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease?
    Metabolism. 2024 May 21:155937. doi: 10.1016/j.metabol.2024.155937.
    PubMed     Abstract available


  32. AVENDANO MS, Perdices-Lopez C, Guerrero-Ruiz Y, Ruiz-Pino F, et al
    The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.
    Metabolism. 2024 May 8:155932. doi: 10.1016/j.metabol.2024.155932.
    PubMed     Abstract available


  33. NEDELCUT S, Axer S, Olbers T
    The risk and benefit of revisional vs. primary metabolic- bariatric surgery and drug therapy - A narrative review.
    Metabolism. 2024;154:155799.
    PubMed     Abstract available


    April 2024
  34. ZELJKOVIC A, Vekic J, Stefanovic A
    Obesity and dyslipidemia in early life: Impact on cardiometabolic risk.
    Metabolism. 2024;156:155919.
    PubMed     Abstract available


  35. AWAZAWA M, Matsushita M, Nomura I, Kobayashi N, et al
    Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice.
    Metabolism. 2024;153:155796.
    PubMed     Abstract available


  36. ROSENDO-SILVA D, Gomes PB, Rodrigues T, Viana S, et al
    Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.
    Metabolism. 2024;153:155788.
    PubMed     Abstract available


    March 2024
  37. PENDERGRAST LA, Ashcroft SP, Ehrlich AM, Treebak JT, et al
    Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice.
    Metabolism. 2024 Mar 11:155834. doi: 10.1016/j.metabol.2024.155834.
    PubMed     Abstract available


  38. MENG M, Cao Y, Qiu J, Shan G, et al
    Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner.
    Metabolism. 2024;152:155784.
    PubMed     Abstract available


  39. KOKKINOS A, Tsilingiris D, Simati S, Stefanakis K, et al
    Bariatric surgery, through beneficial effects on underlying mechanisms, improves cardiorenal and liver metabolic risk over an average of ten years of observation: A longitudinal and a case-control study.
    Metabolism. 2024;152:155773.
    PubMed     Abstract available


  40. REGMI P, Young M, Minigo G, Milic N, et al
    Photoperiod and metabolic health: evidence, mechanism, and implications.
    Metabolism. 2024;152:155770.
    PubMed     Abstract available


  41. LAVILLE M, Robert M, Segrestin B
    Barriers to metabolic surgery and how to address them.
    Metabolism. 2024;152:155764.
    PubMed     Abstract available


    February 2024
  42. RACHELLE H, Malak G, Houry P, Marc H, et al
    Mortality risk in patients with obesity and COVID-19 infection: a systematic review and meta-analysis.
    Metabolism. 2024 Feb 13:155812. doi: 10.1016/j.metabol.2024.155812.
    PubMed     Abstract available


  43. SARABHAI T, Kahl S, Gancheva S, Mastrototaro L, et al
    Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease.
    Metabolism. 2024;151:155762.
    PubMed     Abstract available


  44. SAMARASINGHE SNS, Woods C, Miras AD
    Bariatric Surgery in Women with Polycystic Ovary Syndrome.
    Metabolism. 2024;151:155745.
    PubMed     Abstract available


  45. TSILINGIRIS D, Kokkinos A
    Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond.
    Metabolism. 2024;151:155741.
    PubMed     Abstract available


  46. MURPHY E, Finucane FM
    Addressing uncertainty about the role of structured lifestyle modification for metabolic surgery patients.
    Metabolism. 2024;151:155739.
    PubMed     Abstract available


  47. BAUZA-THORBRUGGE M, Vujicic M, Chanclon B, Palsdottir V, et al
    Adiponectin stimulates Sca1(+)CD34(-)-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue.
    Metabolism. 2024;151:155716.
    PubMed     Abstract available


    January 2024
  48. FUKUSHIMA T, Maetani T, Chubachi S, Tanabe N, et al
    Epicardial adipose tissue measured from analysis of adipose tissue area using chest CT imaging is the best potential predictor of COVID-19 severity.
    Metabolism. 2024;150:155715.
    PubMed     Abstract available


  49. ZIQUBU K, Dludla PV, Mabhida SE, Jack BU, et al
    Brown adipose tissue-derived metabolites and their role in regulating metabolism.
    Metabolism. 2024;150:155709.
    PubMed     Abstract available


    October 2023
  50. KATSAROU A, Kouvari M, Hill MA, Mantzoros CS, et al
    Metabolically unhealthy obesity, sarcopenia and their interactions in obesity pathophysiology and therapeutics: Room for improvement in pharmacotherapy.
    Metabolism. 2023 Oct 27:155714. doi: 10.1016/j.metabol.2023.155714.
    PubMed    


  51. STEINBACH E, Masi D, Ribeiro A, Serradas P, et al
    Upper small intestine microbiome in obesity and related metabolic disorders: A new field of investigation.
    Metabolism. 2023 Oct 24:155712. doi: 10.1016/j.metabol.2023.155712.
    PubMed     Abstract available


  52. KARAKASIS P, Patoulias D, Pamporis K, Stachteas P, et al
    Safety and efficacy of the new, oral, small-molecule, GLP-1 receptor agonists orforglipron and danuglipron for the treatment of type 2 diabetes and obesity: systematic review and meta-analysis of randomized controlled trials.
    Metabolism. 2023 Oct 16:155710. doi: 10.1016/j.metabol.2023.155710.
    PubMed     Abstract available


  53. TSUKAMOTO S, Suzuki T, Wakui H, Uehara T, et al
    Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity.
    Metabolism. 2023;149:155706.
    PubMed     Abstract available


  54. ULLAH R, Shen Y, Zhou YD, Fu J, et al
    Perinatal metabolic inflammation in the hypothalamus impairs the development of homeostatic feeding circuitry.
    Metabolism. 2023;147:155677.
    PubMed     Abstract available


    September 2023
  55. KOKKORAKIS M, Katsarou A, Katsiki N, Mantzoros CS, et al
    Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery.
    Metabolism. 2023;148:155689.
    PubMed     Abstract available


  56. CHEN W, Cui W, Wu J, Zheng W, et al
    Blocking IL-6 signaling improves glucose tolerance via SLC39A5-mediated suppression of glucagon secretion.
    Metabolism. 2023;146:155641.
    PubMed     Abstract available


    August 2023
  57. POLYZOS SA, Vachliotis ID, Mantzoros CS
    Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease.
    Metabolism. 2023 Aug 4:155676. doi: 10.1016/j.metabol.2023.155676.
    PubMed     Abstract available


  58. HOFFMANN A, Meir AY, Hagemann T, Czechowski P, et al
    A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial.
    Metabolism. 2023;145:155594.
    PubMed     Abstract available


  59. PARK SH, Helsley RN, Fadhul T, Willoughby JLS, et al
    Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
    Metabolism. 2023;145:155591.
    PubMed     Abstract available


    July 2023
  60. FERNANDEZ-SAEZ EM, Losarcos M, Becerril S, Valenti V, et al
    Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD.
    Metabolism. 2023 Jul 28:155663. doi: 10.1016/j.metabol.2023.155663.
    PubMed     Abstract available


  61. MUTURI HT, Ghadieh HE, Abdolahipour R, Stankus HL, et al
    Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.
    Metabolism. 2023;144:155562.
    PubMed     Abstract available


    June 2023
  62. KOSCHKER AC, Warrings B, Morbach C, Seyfried F, et al
    Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe obesity: A randomized controlled trial.
    Metabolism. 2023 Jun 30:155655. doi: 10.1016/j.metabol.2023.155655.
    PubMed     Abstract available


  63. JUNG EJ, Sung KW, Bae TH, Kim HY, et al
    The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD.
    Metabolism. 2023 Jun 27:155644. doi: 10.1016/j.metabol.2023.155644.
    PubMed     Abstract available


  64. AXELROD CL, Dantas WS, Kirwan JP
    Sarcopenic obesity: emerging mechanisms and therapeutic potential.
    Metabolism. 2023 Jun 26:155639. doi: 10.1016/j.metabol.2023.155639.
    PubMed     Abstract available


  65. WEI F, Gu Y, He L, Kapoor A, et al
    HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.
    Metabolism. 2023;145:155631.
    PubMed     Abstract available


  66. BOUTARI C, Hill MA, Procaccini C, Matarese G, et al
    The key role of inflammation in the pathogenesis and management of obesity and CVD.
    Metabolism. 2023 Jun 9:155627. doi: 10.1016/j.metabol.2023.155627.
    PubMed    


  67. OH J, Park C, Kim S, Kim M, et al
    High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity.
    Metabolism. 2023 Jun 9:155629. doi: 10.1016/j.metabol.2023.155629.
    PubMed     Abstract available


  68. DE OLIVEIRA MC, Silveira ALM, de Oliveira ACC, Lana JP, et al
    Eosinophils protect from metabolic alterations triggered by obesity.
    Metabolism. 2023 Jun 7:155613. doi: 10.1016/j.metabol.2023.155613.
    PubMed     Abstract available


  69. LIU B, Zhong Y, Huang D, Yang L, et al
    LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic steatosis.
    Metabolism. 2023 Jun 3:155609. doi: 10.1016/j.metabol.2023.155609.
    PubMed     Abstract available


  70. WANG H, Xiong Q, He G, Tang J, et al
    Hepatic IDH2 regulates glycolysis and gluconeogenesis.
    Metabolism. 2023;143:155559.
    PubMed     Abstract available


  71. BARAZZONI R, Cederholm T, Zanetti M, Gortan Cappellari G, et al
    Defining and diagnosing sarcopenia: Is the glass now half full?
    Metabolism. 2023;143:155558.
    PubMed     Abstract available


  72. BRETHVAD AO, Zakariassen HL, Holt J, Lundgren JR, et al
    Increased meal-induced neurotensin response predicts successful maintenance of weight loss - Data from a randomized controlled trial.
    Metabolism. 2023;143:155534.
    PubMed     Abstract available


    May 2023
  73. CAPPELLARI GG, Semolic A, Zanetti M, Vinci P, et al
    Sarcopenic obesity in free-living older adults detected by the ESPEN-EASO consensus diagnostic algorithm: Validation in an Italian cohort and predictive value of insulin resistance and altered plasma ghrelin profile.
    Metabolism. 2023 May 26:155595. doi: 10.1016/j.metabol.2023.155595.
    PubMed     Abstract available


  74. JAVAID HMA, Ko E, Joo EJ, Kwon SH, et al
    TNFalpha-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2.
    Metabolism. 2023;142:155527.
    PubMed     Abstract available


    April 2023
  75. PARK MJ, Choi KM
    Interplay of skeletal muscle and adipose tissue: sarcopenic obesity.
    Metabolism. 2023 Apr 29:155577. doi: 10.1016/j.metabol.2023.155577.
    PubMed     Abstract available


  76. GUO X, Hu J, He G, Chen J, et al
    Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARalpha-mediated functional interplay between mitochondria and peroxisomes.
    Metabolism. 2023 Apr 21:155564. doi: 10.1016/j.metabol.2023.155564.
    PubMed     Abstract available


  77. CHONG B, Kong G, Shankar K, Chew HSJ, et al
    The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000-2019.
    Metabolism. 2023;141:155402.
    PubMed     Abstract available


  78. REBELOS E, Mari A, Oikonen V, Iida H, et al
    Evaluation of renal glucose uptake with [(18)F]FDG-PET: Methodological advancements and metabolic outcomes.
    Metabolism. 2023;141:155382.
    PubMed     Abstract available


    March 2023
  79. PAPADOPOULOS G, Legaki AI, Georgila K, Vorkas P, et al
    Integrated omics analysis for characterization of the contribution of high fructose corn syrup to non-alcoholic fatty liver disease in obesity.
    Metabolism. 2023 Mar 28:155552. doi: 10.1016/j.metabol.2023.155552.
    PubMed     Abstract available


  80. BIANZANO S, Henrich A, Herich L, Kalsch B, et al
    Efficacy and safety of the ghrelin-O-acyltransferase inhibitor BI 1356225 in overweight/obesity: Data from two Phase I, randomised, placebo-controlled studies.
    Metabolism. 2023 Mar 21:155550. doi: 10.1016/j.metabol.2023.155550.
    PubMed     Abstract available


  81. XU H, Yu W, Sun M, Bi Y, et al
    Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca(2+) overload in a Parkin-MCUb-dependent manner.
    Metabolism. 2023 Mar 20:155551. doi: 10.1016/j.metabol.2023.155551.
    PubMed     Abstract available


  82. LUO X, Li Z, Chen L, Zhang X, et al
    Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice.
    Metabolism. 2023 Mar 16:155537. doi: 10.1016/j.metabol.2023.155537.
    PubMed     Abstract available


  83. MARLENE C, Christos MS
    Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy.
    Metabolism. 2023 Mar 2:155531. doi: 10.1016/j.metabol.2023.155531.
    PubMed    


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