Retrieve available abstracts of 83 articles: HTML format
Single Articles
August 2025
ZHANG XD, Zhong YS, Yan H, Jin LH, et al Chemical discovery of a novel MD2/ADAM17 dual-target inhibitor as a potential
therapeutic candidate for saturated fatty acid-induced myocardial inflammatory
injury.
Metabolism. 2025;169:156298. PubMedAbstract available
LEE YH, Lee J, Jeong J, Park K, et al Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated
steatotic liver disease by suppressing SIRT1.
Metabolism. 2025;169:156266. PubMedAbstract available
June 2025
KATSAROU A, Papadopoulos G, Moustakas II, Papadopetraki A, et al Exercise mitigates liver senescence but does not outmatch dietary restriction in
obesity-related MASLD.
Metabolism. 2025 Jun 10:156325. doi: 10.1016/j.metabol.2025.156325. PubMedAbstract available
HINDSO M, Lundsgaard A, Marinkovic B, Jensen MH, et al Fat absorption and metabolism after Roux-en-Y gastric bypass surgery.
Metabolism. 2025;167:156189. PubMedAbstract available
May 2025
GALAN A, Garcia-Garcia F Revisiting gender differences in obesity and type 2 diabetes: Response letter.
Metabolism. 2025 May 29:156307. doi: 10.1016/j.metabol.2025.156307. PubMed
SON YL, Hou J, Kato-Suzuki M, Okamatsu-Ogura Y, et al Corrigendum to "Eva1 deficiency prevents obesity-induced metabolic disorders by
reducing visceral adipose dysfunction" [Metabolism 168 (2025) 156235].
Metabolism. 2025;170:156299. PubMed
ZHU H, Yi X, He M, Wu S, et al Exploring the interplay of genetic variants and environmental factors in
childhood obesity: A systematic review and meta-analysis.
Metabolism. 2025;170:156303. PubMedAbstract available
April 2025
LENG S, Zhang X, Zhao R, Jiang N, et al Mechanical activation of adipose tissue macrophages mediated by Piezo1 protects
against diet-induced obesity by regulating sympathetic activity.
Metabolism. 2025 Apr 7:156262. doi: 10.1016/j.metabol.2025.156262. PubMedAbstract available
ZHONG Y, Wei J, Jiang R Revisiting gender differences in obesity and type 2 diabetes: Letter to the
editor.
Metabolism. 2025 Apr 3:156260. doi: 10.1016/j.metabol.2025.156260. PubMed
March 2025
MOLDOVAN RA, Hidalgo MR, Castane H, Jimenez-Franco A, et al Landscape of sex differences in obesity and type 2 diabetes in subcutaneous
adipose tissue: a systematic review and meta-analysis of transcriptomics studies.
Metabolism. 2025 Mar 27:156241. doi: 10.1016/j.metabol.2025.156241. PubMedAbstract available
RIBAS-LATRE A, Hoffmann A, Gebhardt C, Weiner J, et al The serine protease KLK7 promotes immune cell infiltration in visceral adipose
tissue in obesity.
Metabolism. 2025;168:156239. PubMedAbstract available
SON YL, Hou J, Kato-Suzuki M, Okamatsu-Ogura Y, et al Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral
adipose dysfunction.
Metabolism. 2025 Mar 19:156235. doi: 10.1016/j.metabol.2025.156235. PubMedAbstract available
ZHANG T, Ren Z, Mao R, Yi W, et al LINC00278 and BRG1: A key regulatory axis in male obesity and preadipocyte
adipogenesis.
Metabolism. 2025 Mar 17:156194. doi: 10.1016/j.metabol.2025.156194. PubMedAbstract available
KARAKASIS P, Patoulias D, Fragakis N, Mantzoros CS, et al Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body
composition: Systematic review and network meta-analysis.
Metabolism. 2025;164:156113. PubMedAbstract available
ZENG X, Wang Y, Farias K, Rappa A, et al NRH, a potent NAD(+) enhancer, improves glucose homeostasis and lipid metabolism
in diet-induced obese mice through an active adenosine kinase pathway.
Metabolism. 2025;164:156110. PubMedAbstract available
January 2025
HU Y, Hai J, Ti Y, Kong B, et al Adipose ZFP36 protects against diet-induced obesity and insulin resistance.
Metabolism. 2025;164:156131. PubMedAbstract available
HE Y, Zhang C, Wu S, Li K, et al Central NUCB2/nesfatin-1 signaling ameliorates liver steatosis through
suppression of endoplasmic reticulum stress in the hypothalamus.
Metabolism. 2025;162:156046. PubMedAbstract available
December 2024
MELA V, Martin-Reyes F, Oliva-Olivera W, Cantarero-Cuenca A, et al Serum miR-365b-5p/miR-222-5p as a potential diagnostic biomarker for long-term
weight loss in patients with morbid obesity after bariatric surgery.
Metabolism. 2024 Dec 30:156129. doi: 10.1016/j.metabol.2024.156129. PubMedAbstract available
PERAKAKIS N, Mantzoros CS Evidence from clinical studies of leptin: current and future clinical
applications in humans.
Metabolism. 2024;161:156053. PubMedAbstract available
STEFANAKIS K, Kokkorakis M, Mantzoros CS The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis
health: Implications for emerging pharmacotherapies aiming at fat reduction and
lean mass preservation.
Metabolism. 2024;161:156057. PubMedAbstract available
MUNZBERG H, Heymsfield SB, Berthoud HR, Morrison CD, et al History and future of leptin: Discovery, regulation and signaling.
Metabolism. 2024;161:156026. PubMedAbstract available
November 2024
BUCHWALD LM, Neess D, Hansen D, Doktor TK, et al Body weight control via protein kinase CK2: diet-induced obesity counteracted by
pharmacological targeting.
Metabolism. 2024;162:156060. PubMedAbstract available
ZHANG H, Zhou XD, Shapiro MD, Lip GYH, et al Global burden of metabolic diseases, 1990-2021.
Metabolism. 2024;160:155999. PubMedAbstract available
October 2024
CONFORTO R, Rizzo V, Russo R, Mazza E, et al Advances in body composition and gender differences in susceptibility to frailty
syndrome: Role of osteosarcopenic obesity.
Metabolism. 2024 Oct 26:156052. doi: 10.1016/j.metabol.2024.156052. PubMedAbstract available
SERRANO J, Kondo S, Link GM, Brown IS, et al A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is
associated with enhanced responses to exercise training in older adults with
obesity: A translational study.
Metabolism. 2024 Oct 9:156045. doi: 10.1016/j.metabol.2024.156045. PubMedAbstract available
September 2024
XIE Z, Zheng G, Liang Z, Li M, et al Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss
in patients with obesity or overweight: an updated systematic review and network
meta-analysis of randomized controlled trials.
Metabolism. 2024 Sep 19:156038. doi: 10.1016/j.metabol.2024.156038. PubMedAbstract available
BAGHERI M, Tanriverdi K, Iafrati MD, Mosley JD, et al Characterization of the plasma metabolome and lipidome in response to sleeve
gastrectomy and gastric bypass surgeries reveals molecular patterns of surgical
weight loss.
Metabolism. 2024;158:155955. PubMedAbstract available
August 2024
LIM JH, Kim Y, Kim MY, Kim EN, et al Placental growth factor deficiency initiates obesity- and aging-associated
metabolic syndrome.
Metabolism. 2024 Aug 20:156002. doi: 10.1016/j.metabol.2024.156002. PubMedAbstract available
July 2024
RICHTER MM, Kemp IM, Heeboll S, Winther-Sorensen M, et al Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect
mechanisms.
Metabolism. 2024;156:155915. PubMedAbstract available
June 2024
JOLLET M, Tramontana F, Jiang LQ, Borg ML, et al Diacylglycerol kinase delta overexpression improves glucose clearance and
protects against the development of obesity.
Metabolism. 2024 Jun 4:155939. doi: 10.1016/j.metabol.2024.155939. PubMedAbstract available
May 2024
HUTTASCH M, Roden M, Kahl S Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver
disease?
Metabolism. 2024 May 21:155937. doi: 10.1016/j.metabol.2024.155937. PubMedAbstract available
AVENDANO MS, Perdices-Lopez C, Guerrero-Ruiz Y, Ruiz-Pino F, et al The evolutionary conserved miR-137/325 tandem mediates obesity-induced
hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.
Metabolism. 2024 May 8:155932. doi: 10.1016/j.metabol.2024.155932. PubMedAbstract available
NEDELCUT S, Axer S, Olbers T The risk and benefit of revisional vs. primary metabolic- bariatric surgery and
drug therapy - A narrative review.
Metabolism. 2024;154:155799. PubMedAbstract available
April 2024
ZELJKOVIC A, Vekic J, Stefanovic A Obesity and dyslipidemia in early life: Impact on cardiometabolic risk.
Metabolism. 2024;156:155919. PubMedAbstract available
AWAZAWA M, Matsushita M, Nomura I, Kobayashi N, et al Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut
microbiota in obese model mice.
Metabolism. 2024;153:155796. PubMedAbstract available
ROSENDO-SILVA D, Gomes PB, Rodrigues T, Viana S, et al Clinical and molecular profiling of human visceral adipose tissue reveals
impairment of vascular architecture and remodeling as an early hallmark of
dysfunction.
Metabolism. 2024;153:155788. PubMedAbstract available
March 2024
PENDERGRAST LA, Ashcroft SP, Ehrlich AM, Treebak JT, et al Metabolic plasticity and obesity-associated changes in diurnal postexercise
metabolism in mice.
Metabolism. 2024 Mar 11:155834. doi: 10.1016/j.metabol.2024.155834. PubMedAbstract available
MENG M, Cao Y, Qiu J, Shan G, et al Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an
estrogen dependent manner.
Metabolism. 2024;152:155784. PubMedAbstract available
KOKKINOS A, Tsilingiris D, Simati S, Stefanakis K, et al Bariatric surgery, through beneficial effects on underlying mechanisms, improves
cardiorenal and liver metabolic risk over an average of ten years of observation:
A longitudinal and a case-control study.
Metabolism. 2024;152:155773. PubMedAbstract available
REGMI P, Young M, Minigo G, Milic N, et al Photoperiod and metabolic health: evidence, mechanism, and implications.
Metabolism. 2024;152:155770. PubMedAbstract available
LAVILLE M, Robert M, Segrestin B Barriers to metabolic surgery and how to address them.
Metabolism. 2024;152:155764. PubMedAbstract available
February 2024
RACHELLE H, Malak G, Houry P, Marc H, et al Mortality risk in patients with obesity and COVID-19 infection: a systematic
review and meta-analysis.
Metabolism. 2024 Feb 13:155812. doi: 10.1016/j.metabol.2024.155812. PubMedAbstract available
SARABHAI T, Kahl S, Gancheva S, Mastrototaro L, et al Loss of mitochondrial adaptation associates with deterioration of mitochondrial
turnover and structure in metabolic dysfunction-associated steatotic liver
disease.
Metabolism. 2024;151:155762. PubMedAbstract available
SAMARASINGHE SNS, Woods C, Miras AD Bariatric Surgery in Women with Polycystic Ovary Syndrome.
Metabolism. 2024;151:155745. PubMedAbstract available
TSILINGIRIS D, Kokkinos A Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond.
Metabolism. 2024;151:155741. PubMedAbstract available
MURPHY E, Finucane FM Addressing uncertainty about the role of structured lifestyle modification for
metabolic surgery patients.
Metabolism. 2024;151:155739. PubMedAbstract available
BAUZA-THORBRUGGE M, Vujicic M, Chanclon B, Palsdottir V, et al Adiponectin stimulates Sca1(+)CD34(-)-adipocyte precursor cells associated with
hyperplastic expansion and beiging of brown and white adipose tissue.
Metabolism. 2024;151:155716. PubMedAbstract available
January 2024
FUKUSHIMA T, Maetani T, Chubachi S, Tanabe N, et al Epicardial adipose tissue measured from analysis of adipose tissue area using
chest CT imaging is the best potential predictor of COVID-19 severity.
Metabolism. 2024;150:155715. PubMedAbstract available
ZIQUBU K, Dludla PV, Mabhida SE, Jack BU, et al Brown adipose tissue-derived metabolites and their role in regulating metabolism.
Metabolism. 2024;150:155709. PubMedAbstract available
October 2023
KATSAROU A, Kouvari M, Hill MA, Mantzoros CS, et al Metabolically unhealthy obesity, sarcopenia and their interactions in obesity
pathophysiology and therapeutics: Room for improvement in pharmacotherapy.
Metabolism. 2023 Oct 27:155714. doi: 10.1016/j.metabol.2023.155714. PubMed
STEINBACH E, Masi D, Ribeiro A, Serradas P, et al Upper small intestine microbiome in obesity and related metabolic disorders: A
new field of investigation.
Metabolism. 2023 Oct 24:155712. doi: 10.1016/j.metabol.2023.155712. PubMedAbstract available
KARAKASIS P, Patoulias D, Pamporis K, Stachteas P, et al Safety and efficacy of the new, oral, small-molecule, GLP-1 receptor agonists
orforglipron and danuglipron for the treatment of type 2 diabetes and obesity:
systematic review and meta-analysis of randomized controlled trials.
Metabolism. 2023 Oct 16:155710. doi: 10.1016/j.metabol.2023.155710. PubMedAbstract available
TSUKAMOTO S, Suzuki T, Wakui H, Uehara T, et al Angiotensin II type 1 receptor-associated protein in immune cells: a possible key
factor in the pathogenesis of visceral obesity.
Metabolism. 2023;149:155706. PubMedAbstract available
ULLAH R, Shen Y, Zhou YD, Fu J, et al Perinatal metabolic inflammation in the hypothalamus impairs the development of
homeostatic feeding circuitry.
Metabolism. 2023;147:155677. PubMedAbstract available
September 2023
KOKKORAKIS M, Katsarou A, Katsiki N, Mantzoros CS, et al Milestones in the journey towards addressing obesity; Past trials and triumphs,
recent breakthroughs, and an exciting future in the era of emerging effective
medical therapies and integration of effective medical therapies with metabolic
surgery.
Metabolism. 2023;148:155689. PubMedAbstract available
CHEN W, Cui W, Wu J, Zheng W, et al Blocking IL-6 signaling improves glucose tolerance via SLC39A5-mediated
suppression of glucagon secretion.
Metabolism. 2023;146:155641. PubMedAbstract available
August 2023
POLYZOS SA, Vachliotis ID, Mantzoros CS Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease.
Metabolism. 2023 Aug 4:155676. doi: 10.1016/j.metabol.2023.155676. PubMedAbstract available
HOFFMANN A, Meir AY, Hagemann T, Czechowski P, et al A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory
potential: the DIRECT PLUS randomized controlled trial.
Metabolism. 2023;145:155594. PubMedAbstract available
PARK SH, Helsley RN, Fadhul T, Willoughby JLS, et al Fructose induced KHK-C can increase ER stress independent of its effect on
lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Metabolism. 2023;145:155591. PubMedAbstract available
July 2023
FERNANDEZ-SAEZ EM, Losarcos M, Becerril S, Valenti V, et al Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in
obesity-associated NAFLD.
Metabolism. 2023 Jul 28:155663. doi: 10.1016/j.metabol.2023.155663. PubMedAbstract available
MUTURI HT, Ghadieh HE, Abdolahipour R, Stankus HL, et al Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.
Metabolism. 2023;144:155562. PubMedAbstract available
June 2023
KOSCHKER AC, Warrings B, Morbach C, Seyfried F, et al Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe
obesity: A randomized controlled trial.
Metabolism. 2023 Jun 30:155655. doi: 10.1016/j.metabol.2023.155655. PubMedAbstract available
JUNG EJ, Sung KW, Bae TH, Kim HY, et al The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in
obesity and NAFLD.
Metabolism. 2023 Jun 27:155644. doi: 10.1016/j.metabol.2023.155644. PubMedAbstract available
AXELROD CL, Dantas WS, Kirwan JP Sarcopenic obesity: emerging mechanisms and therapeutic potential.
Metabolism. 2023 Jun 26:155639. doi: 10.1016/j.metabol.2023.155639. PubMedAbstract available
WEI F, Gu Y, He L, Kapoor A, et al HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.
Metabolism. 2023;145:155631. PubMedAbstract available
BOUTARI C, Hill MA, Procaccini C, Matarese G, et al The key role of inflammation in the pathogenesis and management of obesity and
CVD.
Metabolism. 2023 Jun 9:155627. doi: 10.1016/j.metabol.2023.155627. PubMed
OH J, Park C, Kim S, Kim M, et al High levels of intracellular endotrophin in adipocytes mediate COPII vesicle
supplies to autophagosome to impair autophagic flux and contribute to systemic
insulin resistance in obesity.
Metabolism. 2023 Jun 9:155629. doi: 10.1016/j.metabol.2023.155629. PubMedAbstract available
DE OLIVEIRA MC, Silveira ALM, de Oliveira ACC, Lana JP, et al Eosinophils protect from metabolic alterations triggered by obesity.
Metabolism. 2023 Jun 7:155613. doi: 10.1016/j.metabol.2023.155613. PubMedAbstract available
LIU B, Zhong Y, Huang D, Yang L, et al LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic
steatosis.
Metabolism. 2023 Jun 3:155609. doi: 10.1016/j.metabol.2023.155609. PubMedAbstract available
WANG H, Xiong Q, He G, Tang J, et al Hepatic IDH2 regulates glycolysis and gluconeogenesis.
Metabolism. 2023;143:155559. PubMedAbstract available
BARAZZONI R, Cederholm T, Zanetti M, Gortan Cappellari G, et al Defining and diagnosing sarcopenia: Is the glass now half full?
Metabolism. 2023;143:155558. PubMedAbstract available
BRETHVAD AO, Zakariassen HL, Holt J, Lundgren JR, et al Increased meal-induced neurotensin response predicts successful maintenance of
weight loss - Data from a randomized controlled trial.
Metabolism. 2023;143:155534. PubMedAbstract available
May 2023
CAPPELLARI GG, Semolic A, Zanetti M, Vinci P, et al Sarcopenic obesity in free-living older adults detected by the ESPEN-EASO
consensus diagnostic algorithm: Validation in an Italian cohort and predictive
value of insulin resistance and altered plasma ghrelin profile.
Metabolism. 2023 May 26:155595. doi: 10.1016/j.metabol.2023.155595. PubMedAbstract available
JAVAID HMA, Ko E, Joo EJ, Kwon SH, et al TNFalpha-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates
macrophages through adipocyte-derived lipocalin 2.
Metabolism. 2023;142:155527. PubMedAbstract available
April 2023
PARK MJ, Choi KM Interplay of skeletal muscle and adipose tissue: sarcopenic obesity.
Metabolism. 2023 Apr 29:155577. doi: 10.1016/j.metabol.2023.155577. PubMedAbstract available
GUO X, Hu J, He G, Chen J, et al Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue
via PPARalpha-mediated functional interplay between mitochondria and peroxisomes.
Metabolism. 2023 Apr 21:155564. doi: 10.1016/j.metabol.2023.155564. PubMedAbstract available
CHONG B, Kong G, Shankar K, Chew HSJ, et al The global syndemic of metabolic diseases in the young adult population: A
consortium of trends and projections from the Global Burden of Disease 2000-2019.
Metabolism. 2023;141:155402. PubMedAbstract available
REBELOS E, Mari A, Oikonen V, Iida H, et al Evaluation of renal glucose uptake with [(18)F]FDG-PET: Methodological
advancements and metabolic outcomes.
Metabolism. 2023;141:155382. PubMedAbstract available
March 2023
PAPADOPOULOS G, Legaki AI, Georgila K, Vorkas P, et al Integrated omics analysis for characterization of the contribution of high
fructose corn syrup to non-alcoholic fatty liver disease in obesity.
Metabolism. 2023 Mar 28:155552. doi: 10.1016/j.metabol.2023.155552. PubMedAbstract available
BIANZANO S, Henrich A, Herich L, Kalsch B, et al Efficacy and safety of the ghrelin-O-acyltransferase inhibitor BI 1356225 in
overweight/obesity: Data from two Phase I, randomised, placebo-controlled
studies.
Metabolism. 2023 Mar 21:155550. doi: 10.1016/j.metabol.2023.155550. PubMedAbstract available
XU H, Yu W, Sun M, Bi Y, et al Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial
Ca(2+) overload in a Parkin-MCUb-dependent manner.
Metabolism. 2023 Mar 20:155551. doi: 10.1016/j.metabol.2023.155551. PubMedAbstract available
LUO X, Li Z, Chen L, Zhang X, et al Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced
obesity and hepatic steatosis in mice.
Metabolism. 2023 Mar 16:155537. doi: 10.1016/j.metabol.2023.155537. PubMedAbstract available
MARLENE C, Christos MS Advances in physiology, design and development of novel medications changing the
landscape of obesity pharmacotherapy.
Metabolism. 2023 Mar 2:155531. doi: 10.1016/j.metabol.2023.155531. PubMed