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Articles published in Antimicrob Agents Chemother

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Single Articles


    May 2024
  1. CAJAS RA, Santos SSB, Espirito-Santo MCC, Garedaghi Y, et al
    In vitro and in vivo efficacy of the amiodarone and praziquantel combination against the blood fluke Schistosoma mansoni.
    Antimicrob Agents Chemother. 2024 May 23:e0011424. doi: 10.1128/aac.00114.
    PubMed     Abstract available


    April 2024
  2. SAITO M, Wilaisrisak P, Pimanpanarak M, Viladpai-Nguen J, et al
    Comparison of lumefantrine, mefloquine, and piperaquine concentrations between capillary plasma and venous plasma samples in pregnant women with uncomplicated falciparum and vivax malaria.
    Antimicrob Agents Chemother. 2024 Apr 10:e0009324. doi: 10.1128/aac.00093.
    PubMed     Abstract available


  3. AL KHOURY C, Thoumi S, Tokajian S, Sinno A, et al
    ABC transporter inhibition by beauvericin partially overcomes drug resistance in Leishmania tropica.
    Antimicrob Agents Chemother. 2024 Apr 4:e0136823. doi: 10.1128/aac.01368.
    PubMed     Abstract available


    March 2024
  4. SPRINGER E, Heimsch KC, Rahlfs S, Becker K, et al
    Real-time measurements of ATP dynamics via ATeams in Plasmodium falciparum reveal drug-class-specific response patterns.
    Antimicrob Agents Chemother. 2024 Mar 19:e0169023. doi: 10.1128/aac.01690.
    PubMed     Abstract available


  5. YAN M, Liu H, Su Y, Bi X, et al
    Inhibition of AMPK activation in Echinococcus granulosus sensu stricto limits the parasite's glucose metabolism and survival.
    Antimicrob Agents Chemother. 2024;68:e0120223.
    PubMed     Abstract available


    February 2024
  6. SOME AF, Conrad MD, Kabre Z, Fofana A, et al
    Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso.
    Antimicrob Agents Chemother. 2024 Feb 27:e0153423. doi: 10.1128/aac.01534.
    PubMed     Abstract available


  7. ROMAN-ALAMO L, Avalos-Padilla Y, Bouzon-Arnaiz I, Iglesias V, et al
    Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability.
    Antimicrob Agents Chemother. 2024 Feb 13:e0112723. doi: 10.1128/aac.01127.
    PubMed     Abstract available


    January 2024
  8. CHEVALIER FD, Le Clec'h W, Berriman M, Anderson TJ, et al
    A single locus determines praziquantel response in Schistosoma mansoni.
    Antimicrob Agents Chemother. 2024 Jan 30:e0143223. doi: 10.1128/aac.01432.
    PubMed     Abstract available


  9. GREYLING N, van der Watt M, Gwarinda H, van Heerden A, et al
    Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates.
    Antimicrob Agents Chemother. 2024 Jan 23:e0129123. doi: 10.1128/aac.01291.
    PubMed     Abstract available


  10. CHERY-KARSCHNEY L, Patrapuvich R, Mudeppa DG, Kokkonda S, et al
    Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum.
    Antimicrob Agents Chemother. 2024 Jan 9:e0068423. doi: 10.1128/aac.00684.
    PubMed     Abstract available


    December 2023
  11. VAN LOON W, Schallenberg E, Igiraneza C, Habarugira F, et al
    Escalating Plasmodium falciparum K13 marker prevalence indicative of artemisinin resistance in southern Rwanda.
    Antimicrob Agents Chemother. 2023 Dec 11:e0129923. doi: 10.1128/aac.01299.
    PubMed     Abstract available


  12. CRUZ MGFDML, Santi AMM, Morais-Teixeira Ed, Caldeira ASP, et al
    Anti-Leishmania compounds can be screened using Leishmania spp. expressing red fluorescence (tdTomato).
    Antimicrob Agents Chemother. 2023 Dec 8:e0050923. doi: 10.1128/aac.00509.
    PubMed     Abstract available


    November 2023
  13. WATANABE N, Saito-Nakano Y, Kurisawa N, Otomo K, et al
    Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2.
    Antimicrob Agents Chemother. 2023;67:e0056023.
    PubMed     Abstract available


  14. NKEMNGO FN, Raissa LW, Nguete DN, Ndo C, et al
    Geographical emergence of sulfadoxine-pyrimethamine drug resistance-associated P. falciparum and P. malariae alleles in co-existing Anopheles mosquito and asymptomatic human populations across Cameroon.
    Antimicrob Agents Chemother. 2023 Nov 10:e0058823. doi: 10.1128/aac.00588.
    PubMed     Abstract available


    October 2023
  15. TOMAZ KCP, Tavella TA, Borba JVB, Salazar-Alvarez LC, et al
    Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity.
    Antimicrob Agents Chemother. 2023 Oct 11:e0058923. doi: 10.1128/aac.00589.
    PubMed     Abstract available


    September 2023
  16. LUCKY AB, Wang C, Shakri AR, Kalamuddin M, et al
    Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses.
    Antimicrob Agents Chemother. 2023 Sep 13:e0057723. doi: 10.1128/aac.00577.
    PubMed     Abstract available


    June 2023
  17. YIPSIRIMETEE A, Tipthara P, Hanboonkunupakarn B, Tripura R, et al
    Activity of Ivermectin and Its Metabolites against Asexual Blood Stage Plasmodium falciparum and Its Interactions with Antimalarial Drugs.
    Antimicrob Agents Chemother. 2023 Jun 20:e0173022. doi: 10.1128/aac.01730.
    PubMed     Abstract available


  18. ZHANG X, Sicalo Gianechini L, Li K, Kaplan RM, et al
    Broad-Spectrum Inhibitors for Conserved Unique Phosphoethanolamine Methyltransferases in Parasitic Nematodes Possess Anthelmintic Efficacy.
    Antimicrob Agents Chemother. 2023;67:e0000823.
    PubMed     Abstract available


    May 2023
  19. CASTANEDA-MOGOLLON D, Toppings NB, Kamaliddin C, Lang R, et al
    Amplicon Deep Sequencing Reveals Multiple Genetic Events Lead to Treatment Failure with Atovaquone-Proguanil in Plasmodium falciparum.
    Antimicrob Agents Chemother. 2023 May 8:e0170922. doi: 10.1128/aac.01709.
    PubMed     Abstract available


  20. DEMARTA-GATSI C, Andenmatten N, Jimenez-Diaz MB, Gobeau N, et al
    Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model.
    Antimicrob Agents Chemother. 2023 May 3:e0157422. doi: 10.1128/aac.01574.
    PubMed     Abstract available


    April 2023
  21. PLATON L, Baker DA, Menard D
    Modified Plasmodium falciparum Ring-Stage Survival Assay with ML10 Kinase Inhibitor.
    Antimicrob Agents Chemother. 2023 Apr 26:e0001723. doi: 10.1128/aac.00017.
    PubMed     Abstract available


  22. REDHI D, Mulubwa M, Gibhard L, Chibale K, et al
    Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study.
    Antimicrob Agents Chemother. 2023 Apr 3:e0134522. doi: 10.1128/aac.01345.
    PubMed     Abstract available


    March 2023
  23. ROSILLO SR, Dimbu PR, Candido ALM, Oh JM, et al
    Molecular Markers of Sulfadoxine-Pyrimethamine Resistance in Samples from Children with Uncomplicated Plasmodium falciparum at Three Sites in Angola in 2019.
    Antimicrob Agents Chemother. 2023 Mar 14:e0160122. doi: 10.1128/aac.01601.
    PubMed     Abstract available


    January 2023
  24. RYAN KT, Wheeler NJ, Kamara IK, Johnson H, et al
    Phenotypic Profiling of Macrocyclic Lactones on Parasitic Schistosoma Flatworms.
    Antimicrob Agents Chemother. 2023 Jan 25:e0123022. doi: 10.1128/aac.01230.
    PubMed     Abstract available


  25. SINGH BK, Zhang C, Wu J, Peng YC, et al
    A Plasmodium falciparum RING Finger E3 Ubiquitin Ligase Modifies the Roles of PfMDR1 and PfCRT in Parasite Drug Responses.
    Antimicrob Agents Chemother. 2023 Jan 10:e0082122. doi: 10.1128/aac.00821.
    PubMed     Abstract available


    November 2022
  26. WICHA SG, Walz A, Cherkaoui-Rbati MH, Bundgaard N, et al
    New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations.
    Antimicrob Agents Chemother. 2022;66:e0055622.
    PubMed     Abstract available


  27. KAMIL M, Atmaca HN, Unal S, Kina UY, et al
    An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite.
    Antimicrob Agents Chemother. 2022 Nov 7:e0026922. doi: 10.1128/aac.00269.
    PubMed     Abstract available


  28. OUOLOGUEM DT, Dembele L, Dara A, Kone AK, et al
    A Novel Ex Vivo Drug Assay for Assessing the Transmission-Blocking Activity of Compounds on Field-Isolated Plasmodium falciparum Gametocytes.
    Antimicrob Agents Chemother. 2022 Nov 2:e0100122. doi: 10.1128/aac.01001.
    PubMed     Abstract available


    October 2022
  29. NURKANTO A, Imamura R, Rahmawati Y, Prabandari EE, et al
    Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library.
    Antimicrob Agents Chemother. 2022 Oct 31:e0042022. doi: 10.1128/aac.00420.
    PubMed     Abstract available


    September 2022
  30. GARG S, Kreutzfeld O, Chelebieva S, Tumwebaze PK, et al
    Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
    Antimicrob Agents Chemother. 2022 Sep 12:e0081722. doi: 10.1128/aac.00817.
    PubMed     Abstract available


    August 2022
  31. WESTERCAMP N, Owidhi M, Otieno K, Chebore W, et al
    Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria among Children in Western Kenya, 2016 to 2017.
    Antimicrob Agents Chemother. 2022 Aug 29:e0020722. doi: 10.1128/aac.00207.
    PubMed     Abstract available


  32. TADELE G, Jaiteh FK, Oboh M, Oriero E, et al
    Persistence of Residual Submicroscopic P. falciparum Parasitemia following Treatment of Artemether-Lumefantrine in Ethio-Sudan Border, Western Ethiopia.
    Antimicrob Agents Chemother. 2022 Aug 22:e0000222. doi: 10.1128/aac.00002.
    PubMed     Abstract available


  33. KANATANI S, Elahi R, Kanchanabhogin S, Vartak N, et al
    Screening the Pathogen Box for Inhibition of Plasmodium falciparum Sporozoite Motility Reveals a Critical Role for Kinases in Transmission Stages.
    Antimicrob Agents Chemother. 2022 Aug 9:e0041822. doi: 10.1128/aac.00418.
    PubMed     Abstract available


    July 2022
  34. KUMAR A, Das S, Purkait B, Sardar AH, et al
    Correction for Kumar et al., "Ascorbate Peroxidase, a Key Molecule Regulating Amphotericin B Resistance in Clinical Isolates of Leishmania donovani".
    Antimicrob Agents Chemother. 2022 Jul 21:e0082922. doi: 10.1128/aac.00829.
    PubMed    


  35. RADOHERY GFR, Walz A, Gumpp C, Cherkaoui-Rbati MH, et al
    Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.
    Antimicrob Agents Chemother. 2022;66:e0011422.
    PubMed     Abstract available


  36. RAMALINGAM K, Gangwar S, Balodi DC, Anand A, et al
    Leishmania donovani Dipeptidylcarboxypeptidase Inhibitor as a Potential Oral Treatment for Visceral Leishmaniasis.
    Antimicrob Agents Chemother. 2022 Jul 19:e0236121. doi: 10.1128/aac.02361.
    PubMed     Abstract available


  37. SARAH-MATIO EM, Guillochon E, Nsango SE, Abate L, et al
    Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic Infections.
    Antimicrob Agents Chemother. 2022 Jul 6:e0018822. doi: 10.1128/aac.00188.
    PubMed     Abstract available


    April 2022
  38. MOORE CM, Wang J, Lin Q, Ferreira P, et al
    Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast.
    Antimicrob Agents Chemother. 2022 Apr 25:e0207921. doi: 10.1128/aac.02079.
    PubMed     Abstract available


    March 2022
  39. OKITWI M, Orena S, Thomas K, Tumwebaze PK, et al
    Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates.
    Antimicrob Agents Chemother. 2022 Mar 10:e0143721. doi: 10.1128/aac.01437.
    PubMed     Abstract available


  40. BERNEBURG I, Peddibhotla S, Heimsch KC, Haeussler K, et al
    An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
    Antimicrob Agents Chemother. 2022 Mar 10:e0210921. doi: 10.1128/aac.02109.
    PubMed     Abstract available


    January 2022
  41. YIPSIRIMETEE A, Chiewpoo P, Tripura R, Lek D, et al
    Assessment in vitro of the antimalarial and transmission blocking activities of Cipargamin and Ganaplacide in artemisinin resistant Plasmodium falciparum.
    Antimicrob Agents Chemother. 2022 Jan 3:AAC0148121. doi: 10.1128/AAC.01481.
    PubMed     Abstract available


    October 2021
  42. FERNANDEZ OL, Rosales-Chilama M, Quintero N, Travi BL, et al
    Potency and preclinical evidence of synergy of oral azole drugs and miltefosine in an ex vivo model of Leishmania (Viannia) panamensis infection.
    Antimicrob Agents Chemother. 2021 Oct 25:AAC0142521. doi: 10.1128/AAC.01425.
    PubMed     Abstract available


  43. KANAI M, Yeo T, Asua V, Rosenthal PJ, et al
    Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.
    Antimicrob Agents Chemother. 2021 Oct 25:AAC0116321. doi: 10.1128/AAC.01163.
    PubMed     Abstract available


  44. VELASQUEZ AMA, Bartlett PJ, Linares IAP, Passalacqua TG, et al
    New insights into the mechanism of action of the cyclopalladated complex - CP2 in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction and Cell Death.
    Antimicrob Agents Chemother. 2021 Oct 11:AAC0076721. doi: 10.1128/AAC.00767.
    PubMed     Abstract available


  45. PALOQUE L, Coppee R, Stokes BH, Gnadig NF, et al
    Mutation in Plasmodium falciparum BTB/POZ domain of K13 protein confers artemisinin resistance.
    Antimicrob Agents Chemother. 2021 Oct 4:AAC0132021. doi: 10.1128/AAC.01320.
    PubMed     Abstract available


    September 2021
  46. MANH ND, Thanh NV, Quang HH, Van NTT, et al
    Pyronaridine-Artesunate (Pyramax(R)) for the Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam.
    Antimicrob Agents Chemother. 2021 Sep 27:AAC0027621. doi: 10.1128/AAC.00276.
    PubMed     Abstract available


  47. IMWONG M, Suwannasin K, Srisutham S, Vongpromek R, et al
    Evolution of multidrug resistance in Plasmodium falciparum: a longitudinal study of genetic resistance markers in the Greater Mekong Subregion.
    Antimicrob Agents Chemother. 2021 Sep 13:AAC0112121. doi: 10.1128/AAC.01121.
    PubMed     Abstract available


    August 2021
  48. ELLIS KM, Lucantoni L, Chavchich M, Abraham M, et al
    The novel bis-1,2,4-triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite.
    Antimicrob Agents Chemother. 2021 Aug 30:AAC0031121. doi: 10.1128/AAC.00311.
    PubMed     Abstract available


  49. ETXEBESTE-MITXELTORENA M, Plano D, Espuelas S, Moreno E, et al
    New phosphoramidates containing selenium as leishmanicidal agents.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0059021. doi: 10.1128/AAC.00590.
    PubMed     Abstract available


  50. KREUTZFELD O, Rasmussen SA, Ramanathan AA, Tumwebaze PK, et al
    Associations between varied susceptibilities of PfATP4 inhibitors and genotypes in Ugandan Plasmodium falciparum isolates.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0077121. doi: 10.1128/AAC.00771.
    PubMed     Abstract available


  51. TALAAM KK, Inaoka DK, Hatta T, Tsubokawa D, et al
    Mitochondria as a potential target for the development of prophylactic and therapeutic drugs against Schistosoma mansoni infection.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0041821. doi: 10.1128/AAC.00418.
    PubMed     Abstract available


  52. PAKOSZ Z, Lin TY, Michalczyk E, Nagano S, et al
    Inhibitory compounds targeting Plasmodium falciparum Gyrase B.
    Antimicrob Agents Chemother. 2021 Aug 2:AAC0026721. doi: 10.1128/AAC.00267.
    PubMed     Abstract available


    July 2021
  53. VAN LOON W, Bergmann C, Habarugira F, Tacoli C, et al
    Changing pattern of Plasmodium falciparum multi-drug resistance-1 gene polymorphisms in southern Rwanda.
    Antimicrob Agents Chemother. 2021 Jul 6:AAC0090121. doi: 10.1128/AAC.00901.
    PubMed     Abstract available


    June 2021
  54. TAN S, Mudeppa DG, Kokkonda S, White J 3rd, et al
    Properties of Plasmodium falciparum with a deleted apicoplast DNA gyrase.
    Antimicrob Agents Chemother. 2021 Jun 21:AAC0058621. doi: 10.1128/AAC.00586.
    PubMed     Abstract available


  55. TABASSUM W, Singh P, Suthram N, Bhattacharyya S, et al
    Elevated DNA damage sensitivity in malaria parasite induced by the synergistic action between PfHsp90 inhibitor and PfRad51 inhibitor.
    Antimicrob Agents Chemother. 2021 Jun 7:AAC0045721. doi: 10.1128/AAC.00457.
    PubMed     Abstract available


  56. BESHIR KB, Diallo N, Some FA, Sombie S, et al
    Persistent sub-microscopic Plasmodium falciparum parasitaemia 72 hours after treatment with artemether-lumefantrine predicts 42-day treatment failure in Mali and Burkina Faso.
    Antimicrob Agents Chemother. 2021 Jun 1:AAC0087321. doi: 10.1128/AAC.00873.
    PubMed     Abstract available


    April 2021
  57. GOMES-ALVES AG, Duarte M, Cruz T, Castro H, et al
    Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evaluation and mechanistic studies.
    Antimicrob Agents Chemother. 2021 Apr 26. pii: AAC.01513.
    PubMed     Abstract available


  58. FENG J, Xu D, Kong X, Lin K, et al
    Characterization of pfmdr1, pfcrt, pfK13, pfubp1, and pfap2mu in travelers returning from Africa with Plasmodium falciparum infections reported in China from 2014-2018.
    Antimicrob Agents Chemother. 2021 Apr 26. pii: AAC.02717.
    PubMed     Abstract available


  59. DICKIE EA, Ronin C, Sa M, Ciesielski F, et al
    Towards chemical validation of Leishmania infantum ribose 5-phosphate isomerase as a drug target.
    Antimicrob Agents Chemother. 2021 Apr 19. pii: AAC.01892.
    PubMed     Abstract available


  60. PERNAUTE-LAU L, Adegnika AA, Zhou Y, Zinsou JF, et al
    Pharmacogene sequencing of a Gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment.
    Antimicrob Agents Chemother. 2021 Apr 19. pii: AAC.00275.
    PubMed     Abstract available


    March 2021
  61. BURGERT L, Zaloumis S, Dini S, Marquart L, et al
    Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.
    Antimicrob Agents Chemother. 2021;65.
    PubMed     Abstract available


    February 2021
  62. LI H, Abraham A, Gazzola D, Hu Y, et al
    Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans.
    Antimicrob Agents Chemother. 2021;65.
    PubMed     Abstract available


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