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Articles published in Eur J Pharmacol

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Single Articles

    May 2020
  1. KISO T, Watabiki T, Sekizawa T
    ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain.
    Eur J Pharmacol. 2020 May 20:173194. doi: 10.1016/j.ejphar.2020.173194.
    PubMed     Abstract available

  2. YU C, Zhang Y, Gao KX, Sun HT, et al
    Serotonergically dependent antihyperalgesic and antiallodynic effects of isoliquiritin in a mouse model of neuropathic pain.
    Eur J Pharmacol. 2020 May 14:173184. doi: 10.1016/j.ejphar.2020.173184.
    PubMed     Abstract available

  3. SANNA MD, Manassero G, Vercelli A, Herdegen T, et al
    The isoform-specific functions of the c-Jun N-terminal kinase (JNK) in a mouse model of antiretroviral-induced painful peripheral neuropathy.
    Eur J Pharmacol. 2020;880:173161.
    PubMed     Abstract available

  4. BOGACKA J, Popiolek-Barczyk K, Pawlik K, Ciechanowska A, et al
    CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain.
    Eur J Pharmacol. 2020 May 11:173166. doi: 10.1016/j.ejphar.2020.173166.
    PubMed     Abstract available

    March 2020
  5. MAO XF, Ahsan MZ, Apryani E, Tang XQ, et al
    Dual mu-opioid receptor and norepinephrine reuptake mechanisms contribute to dezocine- and tapentadol-induced mechanical antiallodynia in cancer pain.
    Eur J Pharmacol. 2020 Mar 12:173062. doi: 10.1016/j.ejphar.2020.173062.
    PubMed     Abstract available

    February 2020
  6. MORAES TR, Elisei LS, Malta IH, Galdino G, et al
    Participation of CXCL1 in the glial cells during neuropathic pain.
    Eur J Pharmacol. 2020 Feb 28:173039. doi: 10.1016/j.ejphar.2020.173039.
    PubMed     Abstract available

  7. MATSUURA W, Nakamoto K, Tokuyama S
    Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice.
    Eur J Pharmacol. 2020;874:173029.
    PubMed     Abstract available

    January 2020
  8. AKBAR S, Subhan F, Shahid M, Wadood A, et al
    6-Methoxyflavanone abate cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study.
    Eur J Pharmacol. 2020 Jan 29:172972. doi: 10.1016/j.ejphar.2020.172972.
    PubMed     Abstract available

  9. HARA K, Haranishi Y, Terada T
    Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.
    Eur J Pharmacol. 2020 Jan 25:172949. doi: 10.1016/j.ejphar.2020.172949.
    PubMed     Abstract available

    December 2019
  10. RAPACZ A, Rybka S, Obniska J, Jodlowska A, et al
    Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain.
    Eur J Pharmacol. 2019;869:172890.
    PubMed     Abstract available

  11. COUTENS B, Derreumaux C, Labaste F, Minville V, et al
    Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
    Eur J Pharmacol. 2019 Dec 20:172884. doi: 10.1016/j.ejphar.2019.172884.
    PubMed     Abstract available

  12. PANG H, Ren Y, Li H, Chen C, et al
    LncRNAs linc00311 and AK141205 are identified as new regulators in STAT3-mediated neuropathic pain in bCCI rats.
    Eur J Pharmacol. 2019;868:172880.
    PubMed     Abstract available

  13. SANNA MD, Borgonetti V, Masini E, Galeotti N, et al
    Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway.
    Eur J Pharmacol. 2019;868:172859.
    PubMed     Abstract available

    October 2019
  14. NAGAKURA Y, Miwa M, Yoshida M, Miura R, et al
    Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
    Eur J Pharmacol. 2019 Oct 4:172716. doi: 10.1016/j.ejphar.2019.172716.
    PubMed     Abstract available

    September 2019
  15. SALAGA M, Binienda A, Tichkule RB, Thakur GA, et al
    Corrigendum to "The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome" [Eur. J. Pharmacol. (2018),
    Eur J Pharmacol. 2019 Sep 10:172656. doi: 10.1016/j.ejphar.2019.172656.

    August 2019
  16. GARCIA G, Noriega-Navarro R, Martinez-Rojas VA, Gutierrez-Lara EJ, et al
    Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.
    Eur J Pharmacol. 2019;862:172631.
    PubMed     Abstract available

    July 2019
  17. DE PRA SDT, David Antoniazzi CT, Ferro PR, Kudsi SQ, et al
    Nociceptive mechanisms involved in the acute and chronic phases of a complex regional pain syndrome type 1 model in mice.
    Eur J Pharmacol. 2019 Jul 18:172555. doi: 10.1016/j.ejphar.2019.172555.
    PubMed     Abstract available

  18. RIGO FK, Bochi GV, Pereira AL, Adamante G, et al
    TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice.
    Eur J Pharmacol. 2019;855:65-74.
    PubMed     Abstract available

    June 2019
  19. AUGUSTO PSA, Braga AV, Rodrigues FF, Morais MI, et al
    Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
    Eur J Pharmacol. 2019;858:172497.
    PubMed     Abstract available

  20. GE MM, Chen SP, Zhou YQ, Li Z, et al
    The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain.
    Eur J Pharmacol. 2019 Jun 19:172475. doi: 10.1016/j.ejphar.2019.172475.
    PubMed     Abstract available

  21. SALIMI S, Tamaddonfard E
    Microinjection of histamine and its H3 receptor agonist and antagonist into the agranular insular cortex influence sensory and affective components of neuropathic pain in rats.
    Eur J Pharmacol. 2019;857:172450.
    PubMed     Abstract available

  22. DE LA LUZ-CUELLAR YE, Rodriguez-Palma EJ, Franco-Enzastiga U, Salinas-Abarca AB, et al
    Blockade of spinal alpha5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats.
    Eur J Pharmacol. 2019 Jun 7:172443. doi: 10.1016/j.ejphar.2019.172443.
    PubMed     Abstract available

  23. MADANRAJ AS, Khan FU, Naveed M, Ali U, et al
    Interventions to chronic prostatitis/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?
    Eur J Pharmacol. 2019 Jun 3:172429. doi: 10.1016/j.ejphar.2019.172429.
    PubMed     Abstract available

    May 2019
  24. MELO ISF, Rodrigues FF, Costa SOAM, Braga AV, et al
    4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-alpha and CXCL1 production and exhibits activity in models of pain and inflammation.
    Eur J Pharmacol. 2019;856:172404.
    PubMed     Abstract available

  25. BECK TC, Reichel CM, Helke KL, Bhadsavle SS, et al
    Non-addictive orally-active kappa opioid agonists for the treatment of peripheral pain in rats.
    Eur J Pharmacol. 2019 May 16. pii: S0014-2999(19)30335.
    PubMed     Abstract available

  26. SHARMA J, Kulshrestha R, Singh N, Jaggi AS, et al
    Dual role of D-amino acid oxidase in experimental pain models.
    Eur J Pharmacol. 2019 May 3. pii: S0014-2999(19)30305.
    PubMed     Abstract available

    April 2019
  27. GARCIA MM, Goicoechea C, Avellanal M, Traseira S, et al
    Comparison of the antinociceptive profiles of morphine and oxycodone in two models of inflammatory and osteoarthritic pain in rat.
    Eur J Pharmacol. 2019 Apr 9. pii: S0014-2999(19)30239.
    PubMed     Abstract available

  28. GAO T, Shi T, Wiesenfeld-Hallin Z, Li T, et al
    Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
    Eur J Pharmacol. 2019;854:101-108.
    PubMed     Abstract available

  29. HE YT, Duan XL, Guo Z, Li HL, et al
    A synthetic peptide disturbing GluN2A/SHP1 interaction in dorsal root ganglion attenuated pathological pain.
    Eur J Pharmacol. 2019 Apr 2. pii: S0014-2999(19)30221.
    PubMed     Abstract available

    March 2019
  30. NOZU T, Miyagishi S, Nozu R, Takakusaki K, et al
    Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.
    Eur J Pharmacol. 2019;852:198-206.
    PubMed     Abstract available

  31. MERCADO-REYES J, Almanza A, Segura-Chama P, Pellicer F, et al
    D2-like receptor agonist synergizes the mu-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat.
    Eur J Pharmacol. 2019 Mar 12. pii: S0014-2999(19)30175.
    PubMed     Abstract available

    February 2019
  32. CORNELISSEN JC, Steele FF, Tenney RD, Obeng S, et al
    Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys.
    Eur J Pharmacol. 2019;844:175-182.
    PubMed     Abstract available

    January 2019
  33. PASQUINUCCI L, Turnaturi R, Montenegro L, Caraci F, et al
    Simultaneous targeting of MOR/DOR: a useful strategy for inflammatory pain modulation.
    Eur J Pharmacol. 2019 Jan 25. pii: S0014-2999(19)30052.
    PubMed     Abstract available

  34. GAZZO G, Girard P, Kamoun N, Verleye M, et al
    Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.
    Eur J Pharmacol. 2019;843:316-322.
    PubMed     Abstract available

    December 2018
  35. FALK S, Appel CK, Bennedbaek HB, Al-Dihaissy T, et al
    Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain.
    Eur J Pharmacol. 2018 Dec 21. pii: S0014-2999(18)30750.
    PubMed     Abstract available

  36. LANDA-JUAREZ AY, Perez-Severiano F, Castaneda-Hernandez G, Ortiz MI, et al
    The antihyperalgesic effect of docosahexaenoic acid in streptozotocin-induced neuropathic pain in the rat involves the opioidergic system.
    Eur J Pharmacol. 2018 Dec 21. pii: S0014-2999(18)30751.
    PubMed     Abstract available

  37. ASANO T, Hattori T, Tanaka KI, Yamakawa N, et al
    Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain.
    Eur J Pharmacol. 2018 Dec 6. pii: S0014-2999(18)30704.
    PubMed     Abstract available

    October 2018
  38. SRIKANTH M, Chew WS, Hind T, Lim SM, et al
    Lysophosphatidic acid and its receptor LPA1 mediate carrageenan induced inflammatory pain in mice.
    Eur J Pharmacol. 2018 Oct 12. pii: S0014-2999(18)30582.
    PubMed     Abstract available

    September 2018
  39. ROJEWSKA E, Piotrowska A, Jurga A, Makuch W, et al
    Zaprinast diminished pain and enhanced opioid analgesia in a rat neuropathic pain model.
    Eur J Pharmacol. 2018 Sep 10. pii: S0014-2999(18)30518.
    PubMed     Abstract available

    August 2018
  40. LI N, Han ZL, Xu B, Zhang MN, et al
    Systemic administration of the bifunctional opioid/neuropeptide FF receptors agonist BN-9 produced peripheral antinociception in preclinical mouse models of pain.
    Eur J Pharmacol. 2018;837:53-63.
    PubMed     Abstract available

  41. SALAGA M, Binienda A, Tichkule RB, Thakur GA, et al
    The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
    Eur J Pharmacol. 2018 Aug 16. pii: S0014-2999(18)30473.
    PubMed     Abstract available

    July 2018
  42. MARTIKAINEN IK, Hagelberg N, Jaaskelainen SK, Hietala J, et al
    Dopaminergic and serotonergic mechanisms in the modulation of pain: In vivo studies in human brain.
    Eur J Pharmacol. 2018 Jul 20. pii: S0014-2999(18)30412.
    PubMed     Abstract available

    June 2018
  43. MERLOS M, Portillo-Salido E, Brenchat A, Aubel B, et al
    Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.
    Eur J Pharmacol. 2018 Jun 19. pii: S0014-2999(18)30353.
    PubMed     Abstract available

  44. FUJITA M, Tamano R, Yoneda S, Omachi S, et al
    Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: different inhibitory mechanism on spinal microglia from minocycline and propentofylline.
    Eur J Pharmacol. 2018 Jun 7. pii: S0014-2999(18)30336.
    PubMed     Abstract available

  45. SHINOHARA A, Andoh T, Saiki I, Kuraishi Y, et al
    Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice.
    Eur J Pharmacol. 2018 Jun 7. pii: S0014-2999(18)30337.
    PubMed     Abstract available

    May 2018
  46. GUI Y, Chen L, Duan S, Li G, et al
    Methyl cinnamate alleviated CCI-induced upregualtion of spinal AMPA receptors and pain hypersensitivity by targeting AMPK.
    Eur J Pharmacol. 2018 May 23. pii: S0014-2999(18)30297.
    PubMed     Abstract available

  47. SCHIENE K, Schroder W, Linz K, Frosch S, et al
    Nociceptin/orphanin FQ opioid peptide (NOP) receptor and micro-opioid peptide (MOP) receptors both contribute to the anti-hypersensitive effect of cebranopadol in a rat model of arthritic pain.
    Eur J Pharmacol. 2018 May 9. pii: S0014-2999(18)30261.
    PubMed     Abstract available

    March 2018
  48. BARAKAT A, Hamdy MM, Elbadr MM
    Uses of fluoxetine in nociceptive pain management: a literature overview.
    Eur J Pharmacol. 2018 Mar 30. pii: S0014-2999(18)30209.
    PubMed     Abstract available

    Linagliptin attenuates chronic post-ischemia pain: possible anti-inflammatory and anti-oxidant mechanisms.
    Eur J Pharmacol. 2018 Mar 29. pii: S0014-2999(18)30198.
    PubMed     Abstract available

  50. ZHAO JY, Yang L, Bai HH, Liu JP, et al
    Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain.
    Eur J Pharmacol. 2018 Mar 8. pii: S0014-2999(18)30148.
    PubMed     Abstract available

  51. RUTTEN K, Schroder W, Christoph T, Koch T, et al
    Selectivity profiling of NOP, MOP, DOP and KOP receptor antagonists in the rat spinal nerve ligation model of mononeuropathic pain.
    Eur J Pharmacol. 2018 Mar 7. pii: S0014-2999(18)30144.
    PubMed     Abstract available

  52. NEMUTLU SAMUR D, Arslan R, Aydin S, Bektas N, et al
    Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms.
    Eur J Pharmacol. 2018 Mar 6. pii: S0014-2999(18)30142.
    PubMed     Abstract available

    February 2018
  53. SANNA MD, Galeotti N
    The HDAC1/c-JUN complex is essential in the promotion of nerve injury-induced neuropathic pain through JNK signalling.
    Eur J Pharmacol. 2018 Feb 22. pii: S0014-2999(18)30119.
    PubMed     Abstract available

  54. OU Y, Su M, Ling Y, Wei Q, et al
    Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain.
    Eur J Pharmacol. 2018;823:105-109.
    PubMed     Abstract available

    January 2018
  55. LIANG X, Yu G, Su R
    Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain.
    Eur J Pharmacol. 2018;823:27-34.
    PubMed     Abstract available

  56. BRITO AMS, Godin AM, Augusto PSA, Menezes RR, et al
    Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-alpha and CXCL-1.
    Eur J Pharmacol. 2018;818:17-25.
    PubMed     Abstract available

    December 2017
  57. RAPACZ A, Obniska J, Koczurkiewicz P, Wojcik-Pszczola K, et al
    Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice.
    Eur J Pharmacol. 2017 Dec 17. pii: S0014-2999(17)30831.
    PubMed     Abstract available

    November 2017
  58. XU S, Qin B, Shi A, Zhao J, et al
    Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats.
    Eur J Pharmacol. 2017 Nov 18. pii: S0014-2999(17)30752.
    PubMed     Abstract available

  59. YAO W, Han Q, Wang L, Niu Z, et al
    Ropivacaine relieves pain and prevents chondrocyte degradation probably through Calcineurin/NFAT1 signaling pathway in osteoarthritis rats.
    Eur J Pharmacol. 2017 Nov 17. pii: S0014-2999(17)30763.
    PubMed     Abstract available

  60. AHLAWAT A, Sharma S
    A new promising simultaneous approach for attenuating type II diabetes mellitus induced neuropathic pain in rats: iNOS inhibition and neuroregeneration.
    Eur J Pharmacol. 2017;818:419-428.
    PubMed     Abstract available

    October 2017
  61. KOPRUSZINSKI CM, Dos Reis RC, Gambeta E, Acco A, et al
    Blockade of endothelin receptors reduces tumor-induced ongoing pain and evoked hypersensitivity in a rat model of facial carcinoma induced pain.
    Eur J Pharmacol. 2017;818:132-140.
    PubMed     Abstract available

    September 2017
  62. TAMADDONFARD E, Erfanparast A, Abbas Farshid A, Delkhosh-Kasmaie F, et al
    Role of ventrolateral orbital cortex muscarinic and nicotinic receptors in modulation of capsaicin-induced orofacial pain-related behaviors in rats.
    Eur J Pharmacol. 2017 Sep 29. pii: S0014-2999(17)30635.
    PubMed     Abstract available

  63. SUDO RT, do Amaral RV, Monteiro CEDS, Pitta IDR, et al
    Antinociception induced by a novel alpha2A adrenergic receptor agonist in rodents acute and chronic pain models.
    Eur J Pharmacol. 2017 Sep 19. pii: S0014-2999(17)30604.
    PubMed     Abstract available

    August 2017
  64. AHMAD N, Subhan F, Islam N, Shahid M, et al
    Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model.
    Eur J Pharmacol. 2017 Aug 30. pii: S0014-2999(17)30548.
    PubMed     Abstract available

    July 2017
  65. ZHANG R, Xu B, Zhang MN, Zhang T, et al
    Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model.
    Eur J Pharmacol. 2017 Jul 27. pii: S0014-2999(17)30499.
    PubMed     Abstract available

  66. SALIMI A, Sabetkasaei M, Raisi H, Labibi F, et al
    Carbamazepine effects on pain management and serum IL-6, IL-10 evaluation in addicted patients undergoing surgery.
    Eur J Pharmacol. 2017 Jul 8. pii: S0014-2999(17)30455.
    PubMed     Abstract available

    June 2017
  67. LIN Y, Liu L, Jiang H, Zhou J, et al
    Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis.
    Eur J Pharmacol. 2017 Jun 26. pii: S0014-2999(17)30438.
    PubMed     Abstract available

  68. DI CESARE MANNELLI L, Ghelardini C, Micheli L, Del Bello F, et al
    Synergic stimulation of serotonin 5-HT1A receptor and alpha2-adrenoceptors for neuropathic pain relief: preclinical effects of 2-substituted imidazoline derivatives.
    Eur J Pharmacol. 2017 Jun 17. pii: S0014-2999(17)30431.
    PubMed     Abstract available

  69. KAUR M, Singh A, Kumar B, Singh SK, et al
    Protective effect of co-administration of curcumin and sildenafil in alcohol induced neuropathy in rats.
    Eur J Pharmacol. 2017;805:58-66.
    PubMed     Abstract available

    April 2017
  70. BENADE V, Nirogi R, Bhyrapuneni G, Daripelli S, et al
    Mechanistic evaluation of Tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats.
    Eur J Pharmacol. 2017 Apr 12. pii: S0014-2999(17)30263.
    PubMed     Abstract available

    March 2017
  71. SPINDOLA HM, Grando R, Figueiredo MC, Basting R, et al
    Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice.
    Eur J Pharmacol. 2017 Mar 16. pii: S0014-2999(17)30203.
    PubMed     Abstract available

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