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Articles published in J Ethnopharmacol

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Single Articles


    November 2025
  1. XU X, Du K, Zhang C, Zheng C, et al
    Hibiscus syriacus L. Flower attenuates ethanol-induced gastric ulcer via modulation of the Nrf2/HO-1, AKT, and JNK pathways.
    J Ethnopharmacol. 2025;357:120920.
    PubMed     Abstract available


  2. MALEKINASAB A, Hoseinpour F, Hashemnia M
    Gastroprotective effects of Heracleum persicum hydroethanolic extract against ethanol-induced gastric ulcer in rats via suppressing oxidative stress and apoptosis.
    J Ethnopharmacol. 2025;357:120907.
    PubMed     Abstract available


  3. LIU L, Wang J, Dong Q, Li X, et al
    Dichloromethane extract from aerial parts of Ferula sinkiangensis prevents anhydrous ethanol-induced acute gastric ulcer by regulating PI3K-Akt/JNK/Nrf2 signaling pathway.
    J Ethnopharmacol. 2025;357:120909.
    PubMed     Abstract available


  4. ZHANG T, Li H, Hao Y, Wang Y, et al
    Exploring the anti-Helicobacter pylori activity and mechanism of Shouhui Tongbian through chemical composition analysis and network pharmacology.
    J Ethnopharmacol. 2025;356:120869.
    PubMed     Abstract available


    August 2025
  5. EL-SAYED EK, Elsayed HE, Khattab MA, Ahmed AA, et al
    Chemical profile and in-vivo antiulcer activity of Aiphanes eggersii Burret aerial Parts: Involvement of Nrf2/HO-1 activation and NF-kappaB suppression.
    J Ethnopharmacol. 2025;352:120235.
    PubMed     Abstract available


  6. QAZI NG, Khan AU, Khan A, Ali F, et al
    In vivo, in vitro and in silico evaluation of Rumex nepalensis Spreng. and its active phytoconstituent (Chrysophanol) in gastrointestinal disorders.
    J Ethnopharmacol. 2025;352:120177.
    PubMed     Abstract available


    July 2025
  7. CHEN Q, Sun Y, Hu X, Xie Q, et al
    The effect and mechanism of Codonopsis Radix and its active components tangshenoside I and lobetyolin on preventing gastric ulcer based on spectrum-effect relationship.
    J Ethnopharmacol. 2025;353.
    PubMed     Abstract available


  8. WEN J, Wu S, Ma X, Zhao Y, et al
    Corrigendum to "Zuojin Pill attenuates Helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in GES-1 cells" [J. Ethnopharmacol. 285 (2022) 114855].
    J Ethnopharmacol. 2025 Jul 2:120210. doi: 10.1016/j.jep.2025.120210.
    PubMed    


    June 2025
  9. LIU Y, Li W, Yang L, Tong Z, et al
    Discovery of Ganodecalone A, from Ganoderma calidophilum for the treatment of acute gastric ulcers by binding to ALOX5 via the MAPK/NF-kappaB/iNOS signaling.
    J Ethnopharmacol. 2025 Jun 5:120082. doi: 10.1016/j.jep.2025.120082.
    PubMed     Abstract available


    April 2025
  10. MOHSEN E, El Fishawy AM, Salama A, Elgohary R, et al
    Unveiling the gastroprotective effect of the ethyl acetate fraction of Cordia africana Lam. roots against ethanol-induced gastric ulcer and Helicobacterpylori.
    J Ethnopharmacol. 2025;348:119841.
    PubMed     Abstract available


  11. ZHANG X, Wang L, Huang L, Cao G, et al
    Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
    J Ethnopharmacol. 2025;348:119793.
    PubMed     Abstract available


  12. SHI JX, Huo JN, Luo X, Zhang Q, et al
    Integrating metabolomics and network pharmacology to investigate Mu Jin Powder prevents ethanol-induced gastric ulcer in rats.
    J Ethnopharmacol. 2025 Apr 4:119730. doi: 10.1016/j.jep.2025.119730.
    PubMed     Abstract available


    March 2025
  13. ZOU Y, Lu B, Feng Z, Chen H, et al
    Anti Helicobacter pylori activity and gastrointestinal protective effects of Terminalia bellirica: Mechanistic insights from in vitro and in vivo studies.
    J Ethnopharmacol. 2025;345:119569.
    PubMed     Abstract available


  14. ZHENG Q, Zhou Y, Han M, Zhang M, et al
    A novel ingredients recipe derived from Shugan-Hewei Formula targeting chemical carcinogenesis-ROS signaling pathway treated gastroesophageal reflux disease.
    J Ethnopharmacol. 2025;344:119566.
    PubMed     Abstract available


    February 2025
  15. WANG M, Zhou J, Li L, Zhang T, et al
    The anti-inflammatory effects of paeonol from Cynanchum paniculatum extracts on LPS-induced macrophage RAW 264.7 cells and Helicobacter pylori-infected gastrointestinal mucosal damaged zebrafish.
    J Ethnopharmacol. 2025;344:119530.
    PubMed     Abstract available


    January 2025
  16. BALKRISHNA A, Sinha S, Shukla S, Bhattacharya K, et al
    Anti-ulcerogenic activity of the marine-pearl derived medicine mukta Pishti in Rat model of pylorus ligation-induced peptic ulcer.
    J Ethnopharmacol. 2025;342:119378.
    PubMed     Abstract available


    December 2024
  17. LI X, Wang J, Zhou J, Xiao H, et al
    Myristica fragrans water extract modulates multiple biological processes to pre-protect anhydrous ethanol-induced gastric ulcers via Akt/JNK/Nrf2 pathway activation.
    J Ethnopharmacol. 2024 Dec 19:119258. doi: 10.1016/j.jep.2024.119258.
    PubMed     Abstract available


  18. CUI G, Wang M, Liu Z, Chang C, et al
    Investigating the therapeutic effects and potential mechanisms of Zuojin Pill in the treatment of gastroesophageal reflux disease.
    J Ethnopharmacol. 2024;340:119230.
    PubMed     Abstract available


  19. ZHANG YL, Li Y, An FX, Sun CY, et al
    Peucedanum praeruptorum Dunn leaf aqueous extract protects against alcoholic gastric injury by inhibiting inflammation and oxidative stress in mice.
    J Ethnopharmacol. 2024;335:118628.
    PubMed     Abstract available


  20. LIN K, Wang Z, Wang E, Zhang X, et al
    Targeting TRPV1 signaling: Galangin improves ethanol-induced gastric mucosal injury.
    J Ethnopharmacol. 2024;335:118605.
    PubMed     Abstract available


    July 2024
  21. ALI DE, El-Shiekh RA, El Sawy MA, Khalifa AA, et al
    In vivo anti- gastric ulcer activity of 7-O-methyl aromadendrin and sakuranetin via mitigating inflammatory and oxidative stress trails.
    J Ethnopharmacol. 2024 Jul 23:118617. doi: 10.1016/j.jep.2024.118617.
    PubMed     Abstract available


  22. ZHANG Y, Hou Y, Ye H, Wang X, et al
    Transcending antibiotic resistance: The potential of mass Galla chinensis et camelliae Fermentata to Dismantle Helicobacter pylori biofilms and enhance anti-biotic activity.
    J Ethnopharmacol. 2024;334:118594.
    PubMed     Abstract available


    June 2024
  23. KUMATIA EK, Antwi S, Asase A
    Analgesic and anti-inflammatory activities of NPK 500 capsules, a Cassia sieberiana DC. - Based herbal analgesic medicine used to treat dysmenorrhea and peptic ulcer, is mediated through the inhibition of PGE2 and iNOS.
    J Ethnopharmacol. 2024;333:118510.
    PubMed     Abstract available


    May 2024
  24. CHEN M, Wu Z, Zou Y, Peng C, et al
    Phellodendron chinense C.K.Schneid: an in vitro study on its anti-Helicobacter pylori effect.
    J Ethnopharmacol. 2024 May 30:118396. doi: 10.1016/j.jep.2024.118396.
    PubMed     Abstract available


  25. LIU J, Jiang J, Xu Q, Xu Y, et al
    Xuanfu Daizhe Tang alleviates reflux esophagitis in rats by inhibiting the STAT1/TREM-1 pathway.
    J Ethnopharmacol. 2024;326:117903.
    PubMed     Abstract available


  26. ZHANG Z, Zheng Y, Zhang B, Wang R, et al
    Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
    J Ethnopharmacol. 2024 May 21:118376. doi: 10.1016/j.jep.2024.118376.
    PubMed     Abstract available


    April 2024
  27. SANCHEZ-QUEZADA V, Velazquez-Guadarrama N, Mendoza-Elizalde S, Hernandez-Iturriaga M, et al
    Bioaccessibility of bioactive compounds present in Persea americana Mill. seed ingredient during oral-gastric digestion with antibacterial capacity against Helicobacter pylori.
    J Ethnopharmacol. 2024 Apr 27:118259. doi: 10.1016/j.jep.2024.118259.
    PubMed     Abstract available


  28. DINAT S, Orchard A, Van Vuuren S
    Antimicrobial activity of Southern African medicinal plants on Helicobacter pylori and Lactobacillus species.
    J Ethnopharmacol. 2024 Apr 23:118238. doi: 10.1016/j.jep.2024.118238.
    PubMed     Abstract available


  29. LI CY, Liao LJ, Yang SX, Wang LY, et al
    Cinnamaldehyde: An effective component of Cinnamomum cassia inhibiting Helicobacter pylori.
    J Ethnopharmacol. 2024;330:118222.
    PubMed     Abstract available


    March 2024
  30. PAN S, Yu X, Liu M, Liu J, et al
    Banxia Xiexin decoction promotes gastric lymphatic pumping by regulating lymphatic smooth muscle cell contraction and energy metabolism in a stress-induced gastric ulceration rat model.
    J Ethnopharmacol. 2024;328:118015.
    PubMed     Abstract available


  31. SIMOMURA VL, Miorando D, de Oliveira BMM, Manica A, et al
    Aqueous extract of the bark of Uncaria tomentosa, an amazonian medicinal plant, promotes gastroprotection and accelerates gastric healing in rats.
    J Ethnopharmacol. 2024;321:117542.
    PubMed     Abstract available


  32. QU H, Zhang Y, Zhou X, Ou H, et al
    Components study on gastroprotective effect and holistic mechanism of the herbal pair Alpinia officinarum - Cyperus rotundus based on spectrum-effect relationship and integrated transcriptome and metabolome analyses.
    J Ethnopharmacol. 2024;321:117494.
    PubMed     Abstract available


    February 2024
  33. NABIL G, Ahmed YH, Ahmed O, Milad SS, et al
    Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways.
    J Ethnopharmacol. 2024 Feb 28:117970. doi: 10.1016/j.jep.2024.117970.
    PubMed     Abstract available


  34. WU T, Zhang H, Jin Y, Zhang M, et al
    The active components and potential mechanisms of Wuji Wan in the treatment of ethanol-induced gastric ulcer: An integrated metabolomics, network pharmacology and experimental validation.
    J Ethnopharmacol. 2024 Feb 8:117901. doi: 10.1016/j.jep.2024.117901.
    PubMed     Abstract available


  35. LIU H, Chen Y, Hu Y, Zhang W, et al
    Protective effects of an alcoholic extract of Kaempferia galanga L. rhizome on ethanol-induced gastric ulcer in mice.
    J Ethnopharmacol. 2024;325:117845.
    PubMed     Abstract available


    January 2024
  36. ALI NB, Abdelhamid Ibrahim SS, Alsherbiny MA, Sheta E, et al
    Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: Involvement of Nrf2/HO-1 and HMGB-1/NF-kappaB trajectories.
    J Ethnopharmacol. 2024;319.
    PubMed     Abstract available


  37. GUO Y, Wu Y, Huang T, Huang D, et al
    Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K/AKT signaling pathway.
    J Ethnopharmacol. 2024 Jan 30:117739. doi: 10.1016/j.jep.2024.117739.
    PubMed     Abstract available


  38. GONG H, Zhao N, Zhu C, Luo L, et al
    Treatment of gastric ulcer, traditional Chinese medicine may be a better choice.
    J Ethnopharmacol. 2024;324:117793.
    PubMed     Abstract available


  39. YU C, Qiu J, Xiong M, Ren B, et al
    Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways.
    J Ethnopharmacol. 2024;318.
    PubMed     Abstract available


  40. DU K, Zheng C, Kuang Z, Sun Y, et al
    Gastroprotective effect of eupatilin, a polymethoxyflavone from Artemisia argyi H.Lev. & Vaniot, in ethanol-induced gastric mucosal injury via NF-kappaB signaling pathway.
    J Ethnopharmacol. 2024;318.
    PubMed     Abstract available


  41. VENTURINI CL, Damazo AS, Silva MJD, Muller JAI, et al
    Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models.
    J Ethnopharmacol. 2024;318.
    PubMed     Abstract available


    November 2023
  42. OU L, Liu HR, Shi XY, Peng C, et al
    Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway.
    J Ethnopharmacol. 2023 Nov 17:117428. doi: 10.1016/j.jep.2023.117428.
    PubMed     Abstract available


    October 2023
  43. WANG X, Chang L, Chen L, He Y, et al
    Integrated network pharmacology and metabolomics to investigate the effects and possible mechanisms of Dehydroevodiamine against ethanol-induced gastric ulcers.
    J Ethnopharmacol. 2023 Oct 23:117340. doi: 10.1016/j.jep.2023.117340.
    PubMed     Abstract available


  44. WANG C, Jiang S, Zheng H, An Y, et al
    Integration of gut microbiome and serum metabolome revealed the effect of Qing-Wei-Zhi-Tong Micro-pills on gastric ulcer in rats.
    J Ethnopharmacol. 2023 Oct 13:117294. doi: 10.1016/j.jep.2023.117294.
    PubMed     Abstract available


    September 2023
  45. SONG H, Xiong M, Yu C, Ren B, et al
    Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms.
    J Ethnopharmacol. 2023 Sep 30:117264. doi: 10.1016/j.jep.2023.117264.
    PubMed     Abstract available


  46. LV Y, Li J, Li Y, Su J, et al
    Unveiling the potential mechanisms of Amomi fructus against gastric ulcers via integrating network pharmacology and in vivo experiments.
    J Ethnopharmacol. 2023 Sep 28:117179. doi: 10.1016/j.jep.2023.117179.
    PubMed     Abstract available


    August 2023
  47. HONG X, Li H, Lin Y, Luo L, et al
    Efficacy and potential therapeutic mechanism of Weiwei decoction on Spasmolytic polypeptide-expressing metaplasia in Helicobacter pylori-infected and Atp4a-knockout mice.
    J Ethnopharmacol. 2023 Aug 18:117062. doi: 10.1016/j.jep.2023.117062.
    PubMed     Abstract available


  48. WU H, Xie X, Tang Q, Huang T, et al
    Epiberberine inhibits Helicobacter pylori and reduces host apoptosis and inflammatory damage by down-regulating urease expression.
    J Ethnopharmacol. 2023 Aug 14:117046. doi: 10.1016/j.jep.2023.117046.
    PubMed     Abstract available


  49. CHEN P, Chen M, Peng C, Yan J, et al
    In vitro anti-bactrical activity and its preliminary mechanism of action of the non-medicinal parts of Sanguisorba officinalis L. against Helicobacter pylori infection.
    J Ethnopharmacol. 2023 Aug 11:116981. doi: 10.1016/j.jep.2023.116981.
    PubMed     Abstract available


  50. BOEING T, de Souza J, Vilhena da Silva RC, Mariano LNB, et al
    Gastroprotective effect of Artemisia absinthium L.: A medicinal plant used in the treatment of digestive disorders.
    J Ethnopharmacol. 2023;312:116488.
    PubMed     Abstract available


    June 2023
  51. FIGUEIREDO FF, Damazo AS, Arunachalam K, Silva MJD, et al
    Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves.
    J Ethnopharmacol. 2023;309:116338.
    PubMed     Abstract available


    May 2023
  52. FENG L, Bao T, Bai L, Mu X, et al
    Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats.
    J Ethnopharmacol. 2023;314:116545.
    PubMed     Abstract available


  53. TANG Q, Ma Z, Tang X, Liu Y, et al
    Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo.
    J Ethnopharmacol. 2023 May 8:116618. doi: 10.1016/j.jep.2023.116618.
    PubMed     Abstract available


    March 2023
  54. GONCIARZ W, Piatczak E, Chmiela M
    The influence of Salvia cadmica Boiss. Extracts on the M1/M2 polarization of macrophages primed with Helicobacter pylori lipopolysaccharide in conjunction with NF-kappa B activation, production of cytokines, phagocytic activity and total DNA methylati
    J Ethnopharmacol. 2023 Mar 13:116386. doi: 10.1016/j.jep.2023.116386.
    PubMed     Abstract available


  55. SANTOS FA, Viana AFSC, Nunes PIG, Portela BYM, et al
    UPLC-QTOF-MS/MS-based metabolomic approach and gastroprotective effect of two chemotypes of Egletes viscosa (L.) less. against ethanol-induced gastric ulcer in mice.
    J Ethnopharmacol. 2023 Mar 7:116348. doi: 10.1016/j.jep.2023.116348.
    PubMed     Abstract available


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