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Articles published in Mol Psychiatry

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Single Articles


    June 2022
  1. NI T, Zhu L, Wang S, Zhu W, et al
    Medial prefrontal cortex Notch1 signalling mediates methamphetamine-induced psychosis via Hes1-dependent suppression of GABAB1 receptor expression.
    Mol Psychiatry. 2022 Jun 22. pii: 10.1038/s41380-022-01662.
    PubMed     Abstract available


  2. CASAS BS, Vitoria G, Prieto CP, Casas M, et al
    Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood-brain barrier function.
    Mol Psychiatry. 2022 Jun 15. pii: 10.1038/s41380-022-01653.
    PubMed     Abstract available


  3. LIU D, Zinski A, Mishra A, Noh H, et al
    Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development.
    Mol Psychiatry. 2022 Jun 14. pii: 10.1038/s41380-022-01654.
    PubMed     Abstract available


  4. MCWHINNEY SR, Brosch K, Calhoun VD, Crespo-Facorro B, et al
    Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.
    Mol Psychiatry. 2022 Jun 14. pii: 10.1038/s41380-022-01616.
    PubMed     Abstract available


  5. BUCK SA, Quincy Erickson-Oberg M, Logan RW, Freyberg Z, et al
    Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia.
    Mol Psychiatry. 2022 Jun 10. pii: 10.1038/s41380-022-01649.
    PubMed     Abstract available


  6. AKINGBUWA WA, Hammerschlag AR, Bartels M, Nivard MG, et al
    Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia.
    Mol Psychiatry. 2022 Jun 3. pii: 10.1038/s41380-022-01621.
    PubMed     Abstract available


  7. OLIVER D, Arribas M, Radua J, Salazar de Pablo G, et al
    Prognostic accuracy and clinical utility of psychometric instruments for individuals at clinical high-risk of psychosis: a systematic review and meta-analysis.
    Mol Psychiatry. 2022 Jun 3. pii: 10.1038/s41380-022-01611.
    PubMed     Abstract available


  8. HYDE J, Carr H, Kelley N, Seneviratne R, et al
    Efficacy of neurostimulation across mental disorders: systematic review and meta-analysis of 208 randomized controlled trials.
    Mol Psychiatry. 2022;27:2709-2719.
    PubMed     Abstract available


    May 2022
  9. KOMATSU H, Onoguchi G, Jerotic S, Kanahara N, et al
    Correction: Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis.
    Mol Psychiatry. 2022 May 27. pii: 10.1038/s41380-022-01620.
    PubMed    


  10. MATLIK K, Garton DR, Montano-Rodriguez AR, Olfat S, et al
    Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia.
    Mol Psychiatry. 2022 May 26. pii: 10.1038/s41380-022-01554.
    PubMed     Abstract available


  11. MOJARAD BA, Engchuan W, Trost B, Backstrom I, et al
    Genome-wide tandem repeat expansions contribute to schizophrenia risk.
    Mol Psychiatry. 2022 May 12. pii: 10.1038/s41380-022-01575.
    PubMed     Abstract available


  12. FASS DM, Lewis MC, Ahmad R, Szucs MJ, et al
    Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.
    Mol Psychiatry. 2022 May 3. pii: 10.1038/s41380-022-01557.
    PubMed     Abstract available


  13. SAARINEN A, Lyytikainen LP, Hietala J, Dobewall H, et al
    Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses-a general population study.
    Mol Psychiatry. 2022 May 3. pii: 10.1038/s41380-022-01581.
    PubMed     Abstract available


  14. KOMATSU H, Onoguchi G, Jerotic S, Kanahara N, et al
    Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis.
    Mol Psychiatry. 2022 May 2. pii: 10.1038/s41380-022-01591.
    PubMed     Abstract available


    April 2022
  15. CUENOD M, Steullet P, Cabungcal JH, Dwir D, et al
    Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia; Response to "Adaptive changes to oxidative stress in schizophrenia by Lena Palaniyappan".
    Mol Psychiatry. 2022 Apr 28. pii: 10.1038/s41380-022-01553.
    PubMed    


  16. WADA M, Noda Y, Iwata Y, Tsugawa S, et al
    Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment.
    Mol Psychiatry. 2022 Apr 20. pii: 10.1038/s41380-022-01572.
    PubMed     Abstract available


  17. ABU-AKEL A, Wood SJ, Upthegrove R, Chisholm K, et al
    Psychosocial functioning in the balance between autism and psychosis: evidence from three populations.
    Mol Psychiatry. 2022 Apr 14. pii: 10.1038/s41380-022-01543.
    PubMed     Abstract available


  18. ABRAM SV, Roach BJ, Fryer SL, Calhoun VD, et al
    Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia.
    Mol Psychiatry. 2022 Apr 14. pii: 10.1038/s41380-022-01502.
    PubMed     Abstract available


  19. ALMULLA AF, Vasupanrajit A, Tunvirachaisakul C, Al-Hakeim HK, et al
    The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
    Mol Psychiatry. 2022 Apr 14. pii: 10.1038/s41380-022-01552.
    PubMed     Abstract available


  20. PALANIYAPPAN L
    Adaptive changes to oxidative stress in schizophrenia.
    Mol Psychiatry. 2022 Apr 8. pii: 10.1038/s41380-022-01550.
    PubMed    


  21. AYORA M, Fraguas D, Abregu-Crespo R, Recio S, et al
    Leukocyte telomere length in patients with schizophrenia and related disorders: a meta-analysis of case-control studies.
    Mol Psychiatry. 2022 Apr 7. pii: 10.1038/s41380-022-01541.
    PubMed     Abstract available


  22. SONG J, Yao S, Kowalec K, Lu Y, et al
    The impact of educational attainment, intelligence and intellectual disability on schizophrenia: a Swedish population-based register and genetic study.
    Mol Psychiatry. 2022 Apr 5. pii: 10.1038/s41380-022-01500.
    PubMed     Abstract available


  23. BELLON A, Feuillet V, Cortez-Resendiz A, Mouaffak F, et al
    Dopamine-induced pruning in monocyte-derived-neuronal-like cells (MDNCs) from patients with schizophrenia.
    Mol Psychiatry. 2022 Apr 1. pii: 10.1038/s41380-022-01514.
    PubMed     Abstract available


  24. REN D, Wei X, Lin L, Yuan F, et al
    A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity.
    Mol Psychiatry. 2022 Apr 1. pii: 10.1038/s41380-022-01530.
    PubMed     Abstract available


  25. PERZEL MANDELL KA, Eagles NJ, Deep-Soboslay A, Tao R, et al
    Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus.
    Mol Psychiatry. 2022;27:2061-2067.
    PubMed     Abstract available


    March 2022
  26. HENKEL ND, Wu X, O'Donovan SM, Devine EA, et al
    Schizophrenia: a disorder of broken brain bioenergetics.
    Mol Psychiatry. 2022 Mar 9. pii: 10.1038/s41380-022-01494.
    PubMed     Abstract available


  27. MEALER RG, Williams SE, Noel M, Yang B, et al
    The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain.
    Mol Psychiatry. 2022 Mar 8. pii: 10.1038/s41380-022-01490.
    PubMed     Abstract available


    February 2022
  28. MCGUINNESS AJ, Davis JA, Dawson SL, Loughman A, et al
    A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia.
    Mol Psychiatry. 2022 Feb 22. pii: 10.1038/s41380-022-01456.
    PubMed     Abstract available


  29. HWANG I, Kim BS, Ko HR, Cho S, et al
    Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.
    Mol Psychiatry. 2022 Feb 15. pii: 10.1038/s41380-022-01458.
    PubMed     Abstract available


  30. DI BIASE MA, Geaghan MP, Reay WR, Seidlitz J, et al
    Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia.
    Mol Psychiatry. 2022 Feb 10. pii: 10.1038/s41380-022-01460.
    PubMed     Abstract available


  31. OLISLAGERS M, Rademaker K, Adan RAH, Lin BD, et al
    Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders.
    Mol Psychiatry. 2022;27:947-955.
    PubMed     Abstract available


  32. KIRSCHNER M, Hodzic-Santor B, Antoniades M, Nenadic I, et al
    Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
    Mol Psychiatry. 2022;27:1167-1176.
    PubMed     Abstract available


    January 2022
  33. MERIKANGAS AK, Shelly M, Knighton A, Kotler N, et al
    What genes are differentially expressed in individuals with schizophrenia? A systematic review.
    Mol Psychiatry. 2022 Jan 28. pii: 10.1038/s41380-021-01420.
    PubMed     Abstract available


  34. EL KHOUEIRY C, Cabungcal JH, Rovo Z, Fournier M, et al
    Developmental oxidative stress leads to T-type Ca(2+) channel hypofunction in thalamic reticular nucleus of mouse models pertinent to schizophrenia.
    Mol Psychiatry. 2022 Jan 25. pii: 10.1038/s41380-021-01425.
    PubMed     Abstract available


  35. LI W, Lv L, Luo XJ
    In vivo study sheds new light on the dendritic spine pathology hypothesis of schizophrenia.
    Mol Psychiatry. 2022 Jan 25. pii: 10.1038/s41380-022-01449.
    PubMed    


  36. SIMPSON EH, Gallo EF, Balsam PD, Javitch JA, et al
    How changes in dopamine D2 receptor levels alter striatal circuit function and motivation.
    Mol Psychiatry. 2022;27:436-444.
    PubMed     Abstract available


  37. NAIR PC, Miners JO, McKinnon RA, Langmead CJ, et al
    Binding of SEP-363856 within TAAR1 and the 5HT1A receptor: implications for the design of novel antipsychotic drugs.
    Mol Psychiatry. 2022;27:88-94.
    PubMed     Abstract available


    December 2021
  38. ERADY C, Amin K, Onilogbo TOAE, Tomasik J, et al
    Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder.
    Mol Psychiatry. 2021 Dec 23. pii: 10.1038/s41380-021-01405.
    PubMed     Abstract available


  39. HASSAN L, Peek N, Lovell K, Carvalho AF, et al
    Disparities in COVID-19 infection, hospitalisation and death in people with schizophrenia, bipolar disorder, and major depressive disorder: a cohort study of the UK Biobank.
    Mol Psychiatry. 2021 Dec 7. pii: 10.1038/s41380-021-01344.
    PubMed     Abstract available


  40. BAGAUTDINOVA J, Zoller D, Schaer M, Padula MC, et al
    Altered cortical thickness development in 22q11.2 deletion syndrome and association with psychotic symptoms.
    Mol Psychiatry. 2021;26:7671-7678.
    PubMed     Abstract available


    November 2021
  41. ALKELAI A, Greenbaum L, Docherty AR, Shabalin AA, et al
    The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders.
    Mol Psychiatry. 2021 Nov 19. pii: 10.1038/s41380-021-01383.
    PubMed     Abstract available


  42. ZHANG R, Sjolander A, Ploner A, Lu D, et al
    Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants.
    Mol Psychiatry. 2021 Nov 19. pii: 10.1038/s41380-021-01387.
    PubMed     Abstract available


  43. NOTARAS M, Lodhi A, Dundar F, Collier P, et al
    Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids.
    Mol Psychiatry. 2021 Nov 17. pii: 10.1038/s41380-021-01316.
    PubMed     Abstract available


  44. EISENBERG DP, Kohn PD, Hegarty CE, Smith NR, et al
    Clinical correlation but no elevation of striatal dopamine synthesis capacity in two independent cohorts of medication-free individuals with schizophrenia.
    Mol Psychiatry. 2021 Nov 17. pii: 10.1038/s41380-021-01337.
    PubMed     Abstract available


  45. PLAVEN-SIGRAY P, Ikonen Victorsson P, Santillo A, Matheson GJ, et al
    Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis.
    Mol Psychiatry. 2021 Nov 10. pii: 10.1038/s41380-021-01349.
    PubMed     Abstract available


  46. CUENOD M, Steullet P, Cabungcal JH, Dwir D, et al
    Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia.
    Mol Psychiatry. 2021 Nov 10. pii: 10.1038/s41380-021-01374.
    PubMed     Abstract available


  47. ZHOU X
    Over-representation of potential SP4 target genes within schizophrenia-risk genes.
    Mol Psychiatry. 2021 Nov 8. pii: 10.1038/s41380-021-01376.
    PubMed     Abstract available


  48. SELLGREN CM, Imbeault S, Larsson MK, Oliveros A, et al
    Correction: GRK3 deficiency elicits brain immune activation and psychosis.
    Mol Psychiatry. 2021 Nov 8. pii: 10.1038/s41380-021-01371.
    PubMed    


  49. CAMPEAU A, Mills RH, Stevens T, Rossitto LA, et al
    Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia.
    Mol Psychiatry. 2021 Nov 5. pii: 10.1038/s41380-021-01339.
    PubMed     Abstract available


  50. GAO Y, Fan Y, Yang Z, Ma Q, et al
    Systems biological assessment of altered cytokine responses to bacteria and fungi reveals impaired immune functionality in schizophrenia.
    Mol Psychiatry. 2021 Nov 2. pii: 10.1038/s41380-021-01362.
    PubMed     Abstract available


  51. LI Q, Wang Z, Zong L, Ye L, et al
    Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function.
    Mol Psychiatry. 2021;26:6630-6642.
    PubMed     Abstract available


    October 2021
  52. CHAN SY, Brady RO, Lewandowski KE, Higgins A, et al
    Dynamic and progressive changes in thalamic functional connectivity over the first five years of psychosis.
    Mol Psychiatry. 2021 Oct 25. pii: 10.1038/s41380-021-01319.
    PubMed     Abstract available


  53. KHADIMALLAH I, Jenni R, Cabungcal JH, Cleusix M, et al
    Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia.
    Mol Psychiatry. 2021 Oct 22. pii: 10.1038/s41380-021-01313.
    PubMed     Abstract available


  54. WOLF DH, Zheng D, Kohler C, Turetsky BI, et al
    Effect of mGluR2 positive allosteric modulation on frontostriatal working memory activation in schizophrenia.
    Mol Psychiatry. 2021 Oct 20. pii: 10.1038/s41380-021-01320.
    PubMed     Abstract available


  55. YANG K, Longo L, Narita Z, Cascella N, et al
    A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance.
    Mol Psychiatry. 2021 Oct 12. pii: 10.1038/s41380-021-01331.
    PubMed     Abstract available


    September 2021
  56. LUO C, Pi X, Hu N, Wang X, et al
    Subtypes of schizophrenia identified by multi-omic measures associated with dysregulated immune function.
    Mol Psychiatry. 2021 Sep 29. pii: 10.1038/s41380-021-01308.
    PubMed     Abstract available


  57. NAKAHARA T, Tsugawa S, Noda Y, Ueno F, et al
    Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of (1)H-magnetic resonance spectroscopy studies.
    Mol Psychiatry. 2021 Sep 28. pii: 10.1038/s41380-021-01297.
    PubMed     Abstract available


  58. SAARENTAUS EC, Havulinna AS, Mars N, Ahola-Olli A, et al
    Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants.
    Mol Psychiatry. 2021;26:4884-4895.
    PubMed     Abstract available


  59. JIA X, Goes FS, Locke AE, Palmer D, et al
    Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.
    Mol Psychiatry. 2021;26:5239-5250.
    PubMed     Abstract available


    August 2021
  60. STAUFFER EM, Bethlehem RAI, Warrier V, Murray GK, et al
    Grey and white matter microstructure is associated with polygenic risk for schizophrenia.
    Mol Psychiatry. 2021 Aug 30. pii: 10.1038/s41380-021-01260.
    PubMed     Abstract available


  61. LI Y, Li S, Liu J, Huo Y, et al
    The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia.
    Mol Psychiatry. 2021 Aug 10. pii: 10.1038/s41380-021-01261.
    PubMed    


  62. RAUBER S, Heming M, Repple J, Ruland T, et al
    Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses.
    Mol Psychiatry. 2021 Aug 6. pii: 10.1038/s41380-021-01244.
    PubMed     Abstract available


  63. TAKAYANAGI Y, Ishizuka K, Laursen TM, Yukitake H, et al
    From population to neuron: exploring common mediators for metabolic problems and mental illnesses.
    Mol Psychiatry. 2021;26:3931-3942.
    PubMed     Abstract available


  64. NI C, Jiang W, Wang Z, Wang Z, et al
    LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia.
    Mol Psychiatry. 2021;26:4511-4528.
    PubMed     Abstract available


  65. CLEYNEN I, Engchuan W, Hestand MS, Heung T, et al
    Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.
    Mol Psychiatry. 2021;26:4496-4510.
    PubMed     Abstract available


  66. GOBSHTIS N, Tfilin M, Fraifeld VE, Turgeman G, et al
    Transplantation of mesenchymal stem cells causes long-term alleviation of schizophrenia-like behaviour coupled with increased neurogenesis.
    Mol Psychiatry. 2021;26:4448-4463.
    PubMed     Abstract available


  67. GREENING DW, Notaras M, Chen M, Xu R, et al
    Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.
    Mol Psychiatry. 2021;26:4431-4447.
    PubMed     Abstract available


  68. HARRISON PJ, Hall N, Mould A, Al-Juffali N, et al
    Cellular calcium in bipolar disorder: systematic review and meta-analysis.
    Mol Psychiatry. 2021;26:4106-4116.
    PubMed     Abstract available


  69. BORGAN F, O'Daly O, Veronese M, Reis Marques T, et al
    The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study.
    Mol Psychiatry. 2021;26:4464-4474.
    PubMed     Abstract available


  70. KOWALEC K, Lu Y, Sariaslan A, Song J, et al
    Increased schizophrenia family history burden and reduced premorbid IQ in treatment-resistant schizophrenia: a Swedish National Register and Genomic Study.
    Mol Psychiatry. 2021;26:4487-4495.
    PubMed     Abstract available


    July 2021
  71. LIU Z, Palaniyappan L, Wu X, Zhang K, et al
    Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis.
    Mol Psychiatry. 2021 Jul 28. pii: 10.1038/s41380-021-01229.
    PubMed     Abstract available


  72. MURPHY CE, Weickert CS
    A new suspect in the unsolved case of neuroinflammation in schizophrenia.
    Mol Psychiatry. 2021 Jul 20. pii: 10.1038/s41380-021-01225.
    PubMed    


  73. WU X, Shukla R, Alganem K, Zhang X, et al
    Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity.
    Mol Psychiatry. 2021 Jul 16. pii: 10.1038/s41380-021-01205.
    PubMed     Abstract available


  74. HEURICH M, Focking M, Mongan D, Cagney G, et al
    Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis.
    Mol Psychiatry. 2021 Jul 5. pii: 10.1038/s41380-021-01197.
    PubMed     Abstract available


  75. SHA Z, Schijven D, Francks C
    Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization.
    Mol Psychiatry. 2021 Jul 1. pii: 10.1038/s41380-021-01204.
    PubMed     Abstract available


  76. STEIXNER-KUMAR AA, Daguano Gastaldi V, Seidel J, Rosenberger A, et al
    Preadult polytoxicomania-strong environmental underpinnings and first genetic hints.
    Mol Psychiatry. 2021;26:3211-3222.
    PubMed     Abstract available


  77. CLIFTON NE, Rees E, Holmans PA, Pardinas AF, et al
    Genetic association of FMRP targets with psychiatric disorders.
    Mol Psychiatry. 2021;26:2977-2990.
    PubMed     Abstract available


    June 2021
  78. ZHU X, Cabungcal JH, Cuenod M, Uliana DL, et al
    Thalamic reticular nucleus impairments and abnormal prefrontal control of dopamine system in a developmental model of schizophrenia: prevention by N-acetylcysteine.
    Mol Psychiatry. 2021 Jun 30. pii: 10.1038/s41380-021-01198.
    PubMed     Abstract available


  79. GUAN F, Ni T, Zhu W, Williams LK, et al
    Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction.
    Mol Psychiatry. 2021 Jun 30. pii: 10.1038/s41380-021-01201.
    PubMed     Abstract available


  80. GAO WJ, Yang SS, Mack NR, Chamberlin LA, et al
    Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction.
    Mol Psychiatry. 2021 Jun 23. pii: 10.1038/s41380-021-01196.
    PubMed     Abstract available


  81. ROGDAKI M, Devroye C, Ciampoli M, Veronese M, et al
    Correction: Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.
    Mol Psychiatry. 2021 Jun 22. pii: 10.1038/s41380-021-01192.
    PubMed    


  82. RADHAKRISHNAN R, Skosnik PD, Ranganathan M, Naganawa M, et al
    In vivo evidence of lower synaptic vesicle density in schizophrenia.
    Mol Psychiatry. 2021 Jun 16. pii: 10.1038/s41380-021-01184.
    PubMed     Abstract available


  83. DEMICHELE-SWEET MAA, Klei L, Creese B, Harwood JC, et al
    Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.
    Mol Psychiatry. 2021 Jun 10. pii: 10.1038/s41380-021-01152.
    PubMed     Abstract available


  84. TIGARET CM, Lin TE, Morrell ER, Sykes L, et al
    Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.
    Mol Psychiatry. 2021;26:1748-1760.
    PubMed     Abstract available


  85. BYRNE EM, Zhu Z, Qi T, Skene NG, et al
    Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders.
    Mol Psychiatry. 2021;26:2070-2081.
    PubMed     Abstract available


  86. PEREZ JM, Berto S, Gleason K, Ghose S, et al
    Hippocampal subfield transcriptome analysis in schizophrenia psychosis.
    Mol Psychiatry. 2021;26:2577-2589.
    PubMed     Abstract available


  87. CAO H, Zhou H, Cannon TD
    Functional connectome-wide associations of schizophrenia polygenic risk.
    Mol Psychiatry. 2021;26:2553-2561.
    PubMed     Abstract available


  88. MA L, Shcherbina A, Chetty S
    Variations and expression features of CYP2D6 contribute to schizophrenia risk.
    Mol Psychiatry. 2021;26:2605-2615.
    PubMed     Abstract available


    May 2021
  89. WEISSLEDER C, North HF, Bitar M, Fullerton JM, et al
    Reduced adult neurogenesis is associated with increased macrophages in the subependymal zone in schizophrenia.
    Mol Psychiatry. 2021 May 31. pii: 10.1038/s41380-021-01149.
    PubMed     Abstract available


  90. DI BIASE MA, Cetin-Karayumak S, Lyall AE, Zalesky A, et al
    White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.
    Mol Psychiatry. 2021 May 24. pii: 10.1038/s41380-021-01128.
    PubMed     Abstract available


  91. CHADHA R, Alganem K, Mccullumsmith RE, Meador-Woodruff JH, et al
    mTOR kinase activity disrupts a phosphorylation signaling network in schizophrenia brain.
    Mol Psychiatry. 2021 May 14. pii: 10.1038/s41380-021-01135.
    PubMed     Abstract available


  92. KARIMI B, Silwal P, Booth S, Padmanabhan N, et al
    Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus.
    Mol Psychiatry. 2021 May 12. pii: 10.1038/s41380-021-01146.
    PubMed     Abstract available


  93. ROGDAKI M, Devroye C, Ciampoli M, Veronese M, et al
    Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.
    Mol Psychiatry. 2021 May 12. pii: 10.1038/s41380-021-01108.
    PubMed     Abstract available


  94. SELLGREN CM, Imbeault S, Larsson MK, Oliveros A, et al
    GRK3 deficiency elicits brain immune activation and psychosis.
    Mol Psychiatry. 2021 May 12. pii: 10.1038/s41380-021-01106.
    PubMed     Abstract available


    April 2021
  95. LI Y, Ma C, Li W, Yang Y, et al
    A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression.
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    FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors.
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    Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes.
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    An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data.
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    Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain.
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    Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population.
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    MAP2 is differentially phosphorylated in schizophrenia, altering its function.
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    Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function.
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    Polygenic risk for autism, attention-deficit hyperactivity disorder, schizophrenia, major depressive disorder, and neuroticism is associated with the experience of childhood abuse.
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    Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence.
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    Altered temporal, but intact spatial, features of transient network dynamics in psychosis.
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    Natural killer cells in first-episode psychosis: an innate immune signature?
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    Incomplete hippocampal inversion in schizophrenia: prevalence, severity, and impact on hippocampal structure.
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    The two-cell model of glucose metabolism: a hypothesis of schizophrenia.
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    Correction: Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population.
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    Genome-wide DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia in the Chinese Han population.
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    Advances in schizophrenia research: glycobiology, white matter abnormalities, and their interactions.
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    November 2020
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    The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies.
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    Neurexins in autism and schizophrenia-a review of patient mutations, mouse models and potential future directions.
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    Imaging synaptic dopamine availability in individuals at clinical high-risk for psychosis: a [(11)C]-(+)-PHNO PET with methylphenidate challenge study.
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    October 2020
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    A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia.
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    Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis.
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    Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis.
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    Identifying multimodal signatures underlying the somatic comorbidity of psychosis: the COMMITMENT roadmap.
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    Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.
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    Exploring the neuropsychiatric spectrum using high-content functional analysis of single-cell signaling networks.
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    Dopamine dysregulation in psychotic relapse after antipsychotic discontinuation: an [(18)F]DOPA and [(11)C]raclopride PET study in first-episode psychosis.
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    Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia.
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    Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids.
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    July 2020
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    Optogenetic manipulation of an ascending arousal system tunes cortical broadband gamma power and reveals functional deficits relevant to schizophrenia.
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    Topology predicts long-term functional outcome in early psychosis.
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    June 2020
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    Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis.
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    Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.
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    Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia.
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    May 2020
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    Cortical cellular diversity and development in schizophrenia.
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    Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies.
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    White matter integrity, duration of untreated psychosis, and antipsychotic treatment response in medication-naive first-episode psychosis patients.
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    Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine.
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    GABA-A receptor differences in schizophrenia: a positron emission tomography study using [(11)C]Ro154513.
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  150. KOSHIYAMA D, Fukunaga M, Okada N, Morita K, et al
    Differences in fractional anisotropy between the patients with schizophrenia and healthy comparison subjects.
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  152. PASSOS IC, Mwangi B
    Machine learning-guided intervention trials to predict treatment response at an individual patient level: an important second step following randomized clinical trials.
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    March 2020
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    Correction: MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.
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  155. GORDOVEZ FJA, McMahon FJ
    The genetics of bipolar disorder.
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  156. SONDERBY IE, Gustafsson O, Doan NT, Hibar DP, et al
    Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.
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    February 2020
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    Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation.
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    January 2020
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    The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine.
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    Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks.
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    Host-parasite interaction associated with major mental illness.
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