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Articles published in Crit Care Med

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Single Articles


    April 2021
  1. OH TK, Park HY, Song IA
    Depression and Long-Term Survival Among South Korean Sepsis Survivors: A Nationwide Cohort Study From 2011 to 2014.
    Crit Care Med. 2021 Apr 8. pii: 00003246-900000000-95275.
    PubMed     Abstract available


  2. LAT I, Coopersmith CM, De Backer D
    The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
    Crit Care Med. 2021;49:623-635.
    PubMed     Abstract available


  3. CARR AC
    Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
    Crit Care Med. 2021;49:e477-e478.
    PubMed    


    March 2021
  4. REN X
    Potential Endotype Transition for Coronavirus Disease 2019-Related Sepsis With Longitudinal Transcriptome Profiling.
    Crit Care Med. 2021 Mar 16. pii: 00003246-900000000-95304.
    PubMed    


    February 2021
  5. BORN S, Dame C, Matthaus-Kramer C, Schlapbach LJ, et al
    Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016.
    Crit Care Med. 2021 Feb 23. doi: 10.1097/CCM.0000000000004919.
    PubMed     Abstract available


  6. WANG HE, Kabeto MM, Gray M, Wadley VG, et al
    Trajectory of Cognitive Decline After Sepsis.
    Crit Care Med. 2021 Feb 18. doi: 10.1097/CCM.0000000000004897.
    PubMed     Abstract available


  7. TAYLOR SP, Anderson WE, Beam K, Taylor B, et al
    The Association Between Antibiotic Delay Intervals and Hospital Mortality Among Patients Treated in the Emergency Department for Suspected Sepsis.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95342.
    PubMed     Abstract available


  8. DEMERLE KM, Angus DC, Baillie JK, Brant E, et al
    Sepsis Subclasses: A Framework for Development and Interpretation.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95341.
    PubMed     Abstract available


  9. YU SC, Betthauser KD, Gupta A, Lyons PG, et al
    Comparison of Sepsis Definitions as Automated Criteria.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95354.
    PubMed     Abstract available


  10. COOPERSMITH CM, Antonelli M, Bauer SR, Deutschman CS, et al
    Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95348.
    PubMed     Abstract available


  11. BEESLEY SJ, Sorensen J, Walkey AJ, Tonna JE, et al
    Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95347.
    PubMed     Abstract available


  12. JACQUEMET PL, Schweizer R, Ruste M, Pozzi M, et al
    Venoarterial Extracorporeal Membranous Oxygenation Should Be Considered as an Appropriate Rescue Therapy for Sepsis-Induced Refractory Cardiogenic Shock.
    Crit Care Med. 2021;49:e210-e211.
    PubMed    


  13. MUNROE E, Prescott HC
    Late Mortality From Sepsis: What We Know and What It Means.
    Crit Care Med. 2021;49:353-355.
    PubMed    


    January 2021
  14. ALHAZZANI W, Evans L, Alshamsi F, Moller MH, et al
    Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
    Crit Care Med. 2021 Jan 28. doi: 10.1097/CCM.0000000000004899.
    PubMed     Abstract available


  15. KELLUM JA, Artigas A, Gunnerson KJ, Honore PM, et al
    Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004845.
    PubMed     Abstract available


  16. LIZZA BD, Betthauser KD, Juang PH, Hampton NB, et al
    Racial Disparities in Readmissions Following Initial Hospitalization for Sepsis.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004809.
    PubMed     Abstract available


  17. BONAZZETTI C, Morena V, Giacomelli A, Oreni L, et al
    Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study.
    Crit Care Med. 2021;49:e31-e40.
    PubMed     Abstract available


    December 2020
  18. FARRAH K, McIntyre L, Doig CJ, Talarico R, et al
    Sepsis-Associated Mortality, Resource Use, and Healthcare Costs: A Propensity-Matched Cohort Study.
    Crit Care Med. 2020 Dec 17. doi: 10.1097/CCM.0000000000004777.
    PubMed     Abstract available


  19. PLATA-MENCHACA EP, Ferrer R
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis.
    Crit Care Med. 2020 Dec 8. doi: 10.1097/CCM.0000000000004776.
    PubMed    


  20. ROWE S, Alcheikh A
    Harm or Benefit of High-Dose Vitamin C in Adult Patients With Sepsis and Glucose-6-Phosphate Dehydrogenase Deficiency?
    Crit Care Med. 2020;48:e1356.
    PubMed    


  21. KADRI SS
    The Sepsis Proxy Pageant: Seeking Beauty in Imperfection.
    Crit Care Med. 2020;48:1917-1919.
    PubMed    


    November 2020
  22. LANKADEVA YR, Peiris RM, Okazaki N, Birchall IE, et al
    Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
    Crit Care Med. 2020 Nov 25. doi: 10.1097/CCM.0000000000004770.
    PubMed     Abstract available


  23. SWEENEY TE, Liesenfeld O, Wacker J, He YD, et al
    Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019.
    Crit Care Med. 2020 Nov 17. doi: 10.1097/CCM.0000000000004786.
    PubMed     Abstract available


  24. WU YL, Yo CH, Hsu WT, Qian F, et al
    Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2020 Nov 16. doi: 10.1097/CCM.0000000000004738.
    PubMed     Abstract available


  25. BANIASADI A, Rezaeirad S, Zare H, Ghassemi MM, et al
    Two-Step Imputation and AdaBoost-Based Classification for Early Prediction of Sepsis on Imbalanced Clinical Data.
    Crit Care Med. 2020 Nov 5. doi: 10.1097/CCM.0000000000004705.
    PubMed     Abstract available


    October 2020
  26. NESARAGI N, Patidar S
    Early Prediction of Sepsis From Clinical Data Using Ratio and Power-Based Features.
    Crit Care Med. 2020 Oct 13. doi: 10.1097/CCM.0000000000004691.
    PubMed     Abstract available


  27. HE Z, Du L, Zhang P, Zhao R, et al
    Early Sepsis Prediction Using Ensemble Learning With Deep Features and Artificial Features Extracted From Clinical Electronic Health Records.
    Crit Care Med. 2020 Oct 12. doi: 10.1097/CCM.0000000000004644.
    PubMed     Abstract available


  28. KEMPKER JA, Rudd KE, Wang HE, Martin GS, et al
    Sepsis Epidemiology Across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, Chasm-A Direct Application of the Institute for Health Metrics and Evaluation Case Definition to Hospital
    Crit Care Med. 2020 Oct 2. doi: 10.1097/CCM.0000000000004577.
    PubMed     Abstract available


  29. SCOTT HF, Brilli RJ, Paul R, Macias CG, et al
    Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement.
    Crit Care Med. 2020;48:e916-e926.
    PubMed     Abstract available


  30. LI X, Xu X, Xie F, Xu X, et al
    A Time-Phased Machine Learning Model for Real-Time Prediction of Sepsis in Critical Care.
    Crit Care Med. 2020;48:e884-e888.
    PubMed     Abstract available


  31. PARK S, Jeon K, Oh DK, Choi EY, et al
    Normothermia in Patients With Sepsis Who Present to Emergency Departments Is Associated With Low Compliance With Sepsis Bundles and Increased In-Hospital Mortality Rate.
    Crit Care Med. 2020;48:1462-1470.
    PubMed     Abstract available


  32. BOURNE DS, Davis BS, Gigli KH, Chang CH, et al
    Economic Analysis of Mandated Protocolized Sepsis Care in New York Hospitals.
    Crit Care Med. 2020;48:1411-1418.
    PubMed     Abstract available


  33. SCHLAPBACH LJ, Watson RS
    Adapting Pediatric Sepsis Criteria for Benchmarking and Quality Control - The Search for the Holy Grail Continues.
    Crit Care Med. 2020;48:1549-1551.
    PubMed    


  34. WALLEY KR, Boyd JH
    Lipoprotein Biology in Sepsis.
    Crit Care Med. 2020;48:1547-1549.
    PubMed    


  35. NOEL C, Schorr C
    Normothermia in Sepsis Warrants More Than a Lukewarm Response.
    Crit Care Med. 2020;48:1538-1540.
    PubMed    


    September 2020
  36. BHAVANI SV, Wolfe KS, Hrusch CL, Greenberg JA, et al
    Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.
    Crit Care Med. 2020 Sep 17. doi: 10.1097/CCM.0000000000004610.
    PubMed     Abstract available


    August 2020
  37. SHAPPELL CN, Klompas M, Rhee C
    Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?
    Crit Care Med. 2020 Aug 24. doi: 10.1097/CCM.0000000000004601.
    PubMed    


  38. BELTRAN-GARCIA J, Osca-Verdegal R, Pallardo FV, Ferreres J, et al
    Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches.
    Crit Care Med. 2020 Aug 18. doi: 10.1097/CCM.0000000000004625.
    PubMed     Abstract available


  39. YANG M, Liu C, Wang X, Li Y, et al
    An Explainable Artificial Intelligence Predictor for Early Detection of Sepsis.
    Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004550.
    PubMed     Abstract available


  40. MAVES RC
    Procalcitonin Is Not an Adequate Tool for Antimicrobial De-Escalation in Sepsis.
    Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004547.
    PubMed    


  41. MORRILL JH, Kormilitzin A, Nevado-Holgado AJ, Swaminathan S, et al
    Utilization of the Signature Method to Identify the Early Onset of Sepsis From Multivariate Physiological Time Series in Critical Care Monitoring.
    Crit Care Med. 2020 Aug 3. doi: 10.1097/CCM.0000000000004510.
    PubMed     Abstract available


  42. SATO R, Kuriyama A
    Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
    Crit Care Med. 2020;48:e722-e729.
    PubMed     Abstract available


  43. DEUTSCHMAN CS, Hellman J, Ferrer Roca R, De Backer D, et al
    The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities.
    Crit Care Med. 2020;48:1217-1232.
    PubMed     Abstract available


  44. GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
    Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
    Crit Care Med. 2020;48:1175-1179.
    PubMed     Abstract available


  45. LEVI M, Vincent JL, Tanaka K, Radford AH, et al
    Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
    Crit Care Med. 2020;48:1140-1147.
    PubMed     Abstract available


    July 2020
  46. BUSCH LM, Sun J, Eichacker PQ, Torabi-Parizi P, et al
    Inhibitory Immune Checkpoint Molecule Expression in Clinical Sepsis Studies: A Systematic Review.
    Crit Care Med. 2020 Jul 20. doi: 10.1097/CCM.0000000000004496.
    PubMed     Abstract available


  47. ZHOU Y, Xu W, Shao A
    Application Prospect of Mesenchymal Stem Cells in the Treatment of Sepsis.
    Crit Care Med. 2020;48:e634.
    PubMed    


  48. SCHINKEL M, Boerman AW, Nanayakkara PWB
    A Different Perspective on the Use of Sepsis Alert.
    Crit Care Med. 2020;48:e632-e633.
    PubMed    


  49. BARBASH IJ
    Disparities in Sepsis Outcomes: A Problem in Need of Solutions.
    Crit Care Med. 2020;48:1079-1080.
    PubMed    


    June 2020
  50. JAGAN N, Morrow LE, Walters RW, Plambeck RW, et al
    Sepsis and the Obesity Paradox: Size Matters in More Than One Way.
    Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004459.
    PubMed     Abstract available


  51. EGUIA E, Bunn C, Kulshrestha S, Markossian T, et al
    Trends, Cost, and Mortality From Sepsis After Trauma in the United States: An Evaluation of the National Inpatient Sample of Hospitalizations, 2012-2016.
    Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004451.
    PubMed     Abstract available


  52. ENGOREN M, Seelhammer T, Freundlich RE, Maile MD, et al
    A Comparison of Sepsis-2 (Systemic Inflammatory Response Syndrome Based) to Sepsis-3 (Sequential Organ Failure Assessment Based) Definitions-A Multicenter Retrospective Study.
    Crit Care Med. 2020 Jun 22. doi: 10.1097/CCM.0000000000004449.
    PubMed     Abstract available


  53. SATO R, Kuriyama A
    Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
    Crit Care Med. 2020 Jun 12. doi: 10.1097/CCM.0000000000004432.
    PubMed     Abstract available


  54. GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
    Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
    Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004430.
    PubMed     Abstract available


  55. LEVI M, Vincent JL, Tanaka K, Radford AH, et al
    Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
    Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004426.
    PubMed     Abstract available


  56. CAWCUTT KA, Beachy M, Peitz GJ
    Antibiotic Delivery in Sepsis: How Do We Improve?
    Crit Care Med. 2020;48:e540-e541.
    PubMed    


  57. COOKSLEY T, Haji-Michael P
    Oncologic Sepsis on the ICU: Two Decades of Improving Outcomes.
    Crit Care Med. 2020;48:925-926.
    PubMed    


  58. SEE H, Slonim AD
    Evaluating the Effect of Policy Changes on Sepsis Outcomes.
    Crit Care Med. 2020;48:919-920.
    PubMed    


  59. RHEE C, Strich JR, Klompas M, Yealy DM, et al
    SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care...But Now Is the Time to Improve SEP-1.
    Crit Care Med. 2020;48:779-782.
    PubMed    


    May 2020
  60. EHLER J, Petzold A, Sharshar T, Ely EW, et al
    Biomarker Panel to Differentiate Brain Injury From Brain Dysfunction in Patients With Sepsis-Associated Encephalopathy.
    Crit Care Med. 2020;48:e436-e437.
    PubMed    


    April 2020
  61. RUSH B, Danziger J, Walley KR, Kumar A, et al
    Treatment in Disproportionately Minority Hospitals Is Associated With Increased Risk of Mortality in Sepsis: A National Analysis.
    Crit Care Med. 2020 Apr 28. doi: 10.1097/CCM.0000000000004375.
    PubMed     Abstract available


  62. OSBORN TM
    Sepsis Mandates Help Clinicians and Patients.
    Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004342.
    PubMed    


  63. LEMIALE V, Pons S, Mirouse A, Tudesq JJ, et al
    Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique Study.
    Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004322.
    PubMed     Abstract available


  64. LINDELL RB, Nishisaki A, Weiss SL, Traynor DM, et al
    Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock.
    Crit Care Med. 2020 Apr 14. doi: 10.1097/CCM.0000000000004329.
    PubMed     Abstract available


  65. CHINAI B, Gaughan J, Schorr C
    Implementation of the Affordable Care Act: A Comparison of Outcomes in Patients With Severe Sepsis and Septic Shock Using the National Inpatient Sample.
    Crit Care Med. 2020 Apr 9. doi: 10.1097/CCM.0000000000004310.
    PubMed     Abstract available


  66. GALIATSATOS P, Follin A, Alghanim F, Sherry M, et al
    The Association Between Neighborhood Socioeconomic Disadvantage and Readmissions for Patients Hospitalized With Sepsis.
    Crit Care Med. 2020 Apr 8. doi: 10.1097/CCM.0000000000004307.
    PubMed     Abstract available


  67. STRICH JR, Wang J, Eichacker PQ
    Sepsis Bundles That Focus on Clinician Judgment and Proven Interventions Are Needed to Increase Bundle Compliance and Effectiveness.
    Crit Care Med. 2020;48:602-605.
    PubMed    


  68. ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
    Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
    Crit Care Med. 2020;48:484-490.
    PubMed     Abstract available


  69. MATSUDA W
    Should We Restrict ICU Admission for Frail Septic Patients?
    Crit Care Med. 2020;48:e342-e343.
    PubMed    


  70. CARLTON EF, Prescott HC
    The authors reply.
    Crit Care Med. 2020;48:e334-e335.
    PubMed    


  71. PATEL S, Katanga JA, Burman S, Said H, et al
    Making Sense of Readmissions.
    Crit Care Med. 2020;48:e333-e334.
    PubMed    


  72. SWEENEY DA, Kalil AC
    Be Quick But Don't Hurry: Septic Shock, Staphylococcus aureus Bacteremia, and the Timing of Appropriate Antibiotics.
    Crit Care Med. 2020;48:608-609.
    PubMed    


  73. SILVA AYO, Amorim EA, Barbosa-Silva MC, Lima MN, et al
    Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice.
    Crit Care Med. 2020;48:e290-e298.
    PubMed     Abstract available


  74. CORL KA, Zeba F, Caffrey AR, Hermenau M, et al
    Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus aureus Bacteremia.
    Crit Care Med. 2020;48:525-532.
    PubMed     Abstract available


  75. LACHMANN G, Knaak C, Vorderwulbecke G, La Rosee P, et al
    Hyperferritinemia in Critically Ill Patients.
    Crit Care Med. 2020;48:459-465.
    PubMed     Abstract available


    March 2020
  76. ALHAZZANI W, Moller MH, Arabi YM, Loeb M, et al
    Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).
    Crit Care Med. 2020 Mar 27. doi: 10.1097/CCM.0000000000004363.
    PubMed     Abstract available


  77. HENDRICKSON CM, Matthay MA
    Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults.
    Crit Care Med. 2020;48:428-430.
    PubMed    


  78. BUSCH LM, Kalil AC, Kadri SS
    Predicting Sepsis Mortality and Costs Using Medicare Claims: A Method to the Madness.
    Crit Care Med. 2020;48:424-426.
    PubMed    


  79. LEVY MM
    Identifying the Burden of Sepsis With Big Data.
    Crit Care Med. 2020;48:422-423.
    PubMed    


  80. RHEE C, Klompas M
    The Eye-Popping Costs Associated With Sepsis Diagnoses Among Medicare Beneficiaries.
    Crit Care Med. 2020;48:420-422.
    PubMed    


  81. WHITNEY JE, Zhang B, Koterba N, Chen F, et al
    Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.
    Crit Care Med. 2020;48:344-352.
    PubMed     Abstract available


  82. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:302-318.
    PubMed     Abstract available


  83. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:289-301.
    PubMed     Abstract available


  84. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:276-288.
    PubMed     Abstract available


  85. KUTTAB HI, Ward MA
    The authors reply.
    Crit Care Med. 2020;48:e260-e261.
    PubMed    


  86. JONES TW, Finder S, Newsome AS, Smith SE, et al
    Getting to the Heart of the Matter: What We Know About Fluid Resuscitation in Septic Heart Failure Patients.
    Crit Care Med. 2020;48:e259-e260.
    PubMed    


  87. LAW AC, Stevens JP, Walkey AJ
    The authors reply.
    Crit Care Med. 2020;48:e249-e250.
    PubMed    


  88. OUD L
    Trends of Time to Hospital Mortality Versus Timing of Death Among Patients With Septic Shock in Administrative Data.
    Crit Care Med. 2020;48:e249.
    PubMed    


  89. MARRARO GA, Spada C, Zeng Y
    Administrative Database and Empiric Therapy Are Always Useful for Appropriate Treatment of Pediatric Patients?
    Crit Care Med. 2020;48:438-440.
    PubMed    


  90. JILANI SM, Giroir BP
    Septic Shock in Children: When Should Prevention Start and Treatment End?
    Crit Care Med. 2020;48:426-428.
    PubMed    


  91. ZADOR Z, Landry A, Balas M, Marshall JC, et al
    Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness.
    Crit Care Med. 2020;48:338-343.
    PubMed     Abstract available


  92. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:329-337.
    PubMed     Abstract available


  93. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:319-328.
    PubMed     Abstract available


  94. BELLETTI A, Nagy A, Sartorelli M, Mucchetti M, et al
    Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials.
    Crit Care Med. 2020;48:398-405.
    PubMed     Abstract available


    February 2020
  95. CARLTON EF, Donnelly JP, Hensley MK, Cornell TT, et al
    New Medical Device Acquisition During Pediatric Severe Sepsis Hospitalizations.
    Crit Care Med. 2020 Feb 27. doi: 10.1097/CCM.0000000000004272.
    PubMed     Abstract available


  96. BINNIE A, Tsang JLY, Hu P, Carrasqueiro G, et al
    Epigenetics of Sepsis.
    Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004247.
    PubMed     Abstract available


  97. KWON MY, Ghanta S, Ng J, Tsoyi K, et al
    Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
    Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004244.
    PubMed     Abstract available


  98. ISHII J, Ohshimo S, Shime N
    Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program.
    Crit Care Med. 2020;48:e161-e162.
    PubMed    


  99. BUCHMAN TG, Zehnbauer BA
    Exploring the Epigenetics of Severe Sepsis: First Step in a Long Journey.
    Crit Care Med. 2020;48:254-255.
    PubMed    


  100. REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
    Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
    Crit Care Med. 2020;48:210-217.
    PubMed     Abstract available


  101. PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
    Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2020;48:200-209.
    PubMed     Abstract available


  102. BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
    Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
    Crit Care Med. 2020;48:142-150.
    PubMed     Abstract available


  103. SARIA S, Henry KE
    Too Many Definitions of Sepsis: Can Machine Learning Leverage the Electronic Health Record to Increase Accuracy and Bring Consensus?
    Crit Care Med. 2020;48:137-141.
    PubMed    


  104. AFSHAR M, Markossian T, Joyce C
    The authors reply.
    Crit Care Med. 2020;48:e162-e163.
    PubMed    


    January 2020
  105. ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
    Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
    Crit Care Med. 2020 Jan 13. doi: 10.1097/CCM.0000000000004179.
    PubMed     Abstract available


  106. LEMASLE L, Blet A, Geven C, Cherifa M, et al
    Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
    Crit Care Med. 2020;48:49-55.
    PubMed     Abstract available


    December 2019
  107. REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
    Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
    Crit Care Med. 2019 Dec 17. doi: 10.1097/CCM.0000000000004145.
    PubMed     Abstract available


  108. BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
    Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
    Crit Care Med. 2019 Dec 11. doi: 10.1097/CCM.0000000000004097.
    PubMed     Abstract available


  109. XIE J, Wang H, Kang Y, Zhou L, et al
    The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey.
    Crit Care Med. 2019 Dec 5. doi: 10.1097/CCM.0000000000004155.
    PubMed     Abstract available


  110. PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
    Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2019 Dec 3. doi: 10.1097/CCM.0000000000004132.
    PubMed     Abstract available


  111. OUD L
    The Impact of Atrial Fibrillation on Short-Term Mortality and Resource Utilization in Sepsis.
    Crit Care Med. 2019;47:e1032.
    PubMed    


    November 2019
  112. PROUT AJ, Talisa VB, Carcillo JA, Decker BK, et al
    Bacterial and Fungal Etiology of Sepsis in Children in the United States: Reconsidering Empiric Therapy.
    Crit Care Med. 2019 Nov 27. doi: 10.1097/CCM.0000000000004140.
    PubMed     Abstract available


  113. SHUBIN NJ, Navalkar K, Sampson D, Yager TD, et al
    Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
    Crit Care Med. 2019 Nov 8. doi: 10.1097/CCM.0000000000004083.
    PubMed     Abstract available


  114. OSUCHOWSKI MF, Rosengart MR
    Change Is the Only Constant: How to Adopt the New Trends in Sepsis Modeling?
    Crit Care Med. 2019;47:1673-1675.
    PubMed    


  115. HOPKINS RO
    Acquired Brain Injury Following Sepsis.
    Crit Care Med. 2019;47:1658-1659.
    PubMed    


  116. SIMPSON SQ
    Sepsis Biomarkers and Physician Judgment in the Emergency Room.
    Crit Care Med. 2019;47:1656-1657.
    PubMed    


    October 2019
  117. SHIMADA T, Topchiy E, Leung AKK, Kong HJ, et al
    Very Low Density Lipoprotein Receptor Sequesters Lipopolysaccharide Into Adipose Tissue During Sepsis.
    Crit Care Med. 2019 Oct 23. doi: 10.1097/CCM.0000000000004064.
    PubMed     Abstract available


  118. LI X, Zhu J, Tian L, Ma X, et al
    Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-kappaB Signaling Pathway.
    Crit Care Med. 2019 Oct 21. doi: 10.1097/CCM.0000000000004065.
    PubMed     Abstract available


  119. YAN X, Tu H, Liu Y, Chen T, et al
    Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis.
    Crit Care Med. 2019 Oct 17. doi: 10.1097/CCM.0000000000004070.
    PubMed     Abstract available


  120. NUSSHAG C, Rupp C, Schmitt F, Krautkramer E, et al
    Cell Cycle Biomarkers and Soluble Urokinase-Type Plasminogen Activator Receptor for the Prediction of Sepsis-Induced Acute Kidney Injury Requiring Renal Replacement Therapy: A Prospective, Exploratory Study.
    Crit Care Med. 2019 Oct 4. doi: 10.1097/CCM.0000000000004042.
    PubMed     Abstract available


  121. PELTAN ID, Liu VX
    More Than We Bargained For: The "Dominating" Cost Effectiveness of Sepsis Quality Improvement?
    Crit Care Med. 2019;47:1464-1467.
    PubMed    


  122. PARKER RI
    Cancer and Sepsis: Adding Insult to Injury-As if Either Alone Were Not Enough?
    Crit Care Med. 2019;47:1452-1453.
    PubMed    


  123. LEVY MM
    Implementation of Sepsis Bundles: Just Do It!!
    Crit Care Med. 2019;47:1450-1451.
    PubMed    


    September 2019
  124. OH SY, Cho S, Kim GH, Jang EJ, et al
    Incidence and Outcomes of Sepsis in Korea: A Nationwide Cohort Study From 2007 to 2016.
    Crit Care Med. 2019 Sep 30. doi: 10.1097/CCM.0000000000004041.
    PubMed     Abstract available


  125. GOULDEN R
    Alternative Explanations for the Obesity Paradox in Sepsis.
    Crit Care Med. 2019;47:e790.
    PubMed    


  126. PITTA MR, Campos FM
    Comment on "Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients".
    Crit Care Med. 2019;47:e789-e790.
    PubMed    


  127. SURESH K, D'Alessio F
    Immune Checkpoint Inhibitor Use in Sepsis: Monitoring Immune Checkpoint Inhibitor Toxicity.
    Crit Care Med. 2019;47:e788.
    PubMed    


  128. OUD L
    Reporting Epidemiologic Studies in Sepsis Combining the International Classification of Diseases, 9th Edition and International Classification of Diseases, 10th Edition Codes.
    Crit Care Med. 2019;47:e785.
    PubMed    


    August 2019
  129. KUTTAB HI, Lykins JD, Hughes MD, Wroblewski K, et al
    Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock.
    Crit Care Med. 2019 Aug 7. doi: 10.1097/CCM.0000000000003960.
    PubMed     Abstract available


  130. STORTZ JA, Hollen MK, Nacionales DC, Horiguchi H, et al
    Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
    Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003926.
    PubMed     Abstract available


  131. GIANNINI HM, Ginestra JC, Chivers C, Draugelis M, et al
    A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice.
    Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003891.
    PubMed     Abstract available


  132. EHLENBACH WJ, Sonnen JA, Montine TJ, Larson EB, et al
    Association Between Sepsis and Microvascular Brain Injury.
    Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003924.
    PubMed     Abstract available


  133. WEISS SL, Zhang D, Bush J, Graham K, et al
    Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis.
    Crit Care Med. 2019 Aug 2. doi: 10.1097/CCM.0000000000003931.
    PubMed     Abstract available


  134. SAMUELS DC, Hulgan T, Fessel JP, Billings FT 4th, et al
    Mitochondrial DNA Haplogroups and Delirium During Sepsis.
    Crit Care Med. 2019;47:1065-1071.
    PubMed     Abstract available


  135. GAZMURI RJ, Anez de Gomez CI, Siddiqui M, Schechtman J, et al
    Severe Sepsis and Septic Shock Early Management Bundle Risks Aiding Vasopressor Misuse.
    Crit Care Med. 2019;47:e717.
    PubMed    


  136. LEE JT, Mikkelsen ME
    Risk Stratification Tools in Sepsis: From Acute Physiology and Chronic Health Evaluation to Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2019;47:1159-1161.
    PubMed    


  137. PARKER RI
    Sepsis: From Little Findings Big Ideas Grow.
    Crit Care Med. 2019;47:1152-1153.
    PubMed    


    July 2019
  138. MIAO H, Shi J, Wang C, Lu G, et al
    Continuous Renal Replacement Therapy in Pediatric Severe Sepsis: A Propensity Score-Matched Prospective Multicenter Cohort Study in the PICU.
    Crit Care Med. 2019 Jul 31. doi: 10.1097/CCM.0000000000003901.
    PubMed     Abstract available


  139. PEPPER DJ, Sun J, Cui X, Welsh J, et al
    Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).
    Crit Care Med. 2019 Jul 31. doi: 10.1097/CCM.0000000000003892.
    PubMed     Abstract available


  140. HENSLEY MK, Donnelly JP, Carlton EF, Prescott HC, et al
    Epidemiology and Outcomes of Cancer-Related Versus Non-Cancer-Related Sepsis Hospitalizations.
    Crit Care Med. 2019 Jul 25. doi: 10.1097/CCM.0000000000003896.
    PubMed     Abstract available


  141. PARK CHL, de Almeida JP, de Oliveira GQ, Rizk SI, et al
    Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial.
    Crit Care Med. 2019 Jul 25. doi: 10.1097/CCM.0000000000003900.
    PubMed     Abstract available


  142. KASHIOURIS MG, Zemore Z, Kimball Z, Stefanou C, et al
    Supply Chain Delays in Antimicrobial Administration After the Initial Clinician Order and Mortality in Patients With Sepsis.
    Crit Care Med. 2019 Jul 24. doi: 10.1097/CCM.0000000000003921.
    PubMed     Abstract available


  143. AFSHAR M, Arain E, Ye C, Gilbert E, et al
    Patient Outcomes and Cost-Effectiveness of a Sepsis Care Quality Improvement Program in a Health System.
    Crit Care Med. 2019 Jul 15. doi: 10.1097/CCM.0000000000003919.
    PubMed     Abstract available


  144. BEALE R
    Enough Is As Good As a Feast.
    Crit Care Med. 2019;47:1004-1006.
    PubMed    


  145. MUTHUMALAIAPPAN K
    Efficacy of Mesenchymal Stem/Stromal Cell Infusion in Septic Patients Is a Puzzle Worthy of Attention.
    Crit Care Med. 2019;47:1001-1002.
    PubMed    


  146. TAPIA P, Gatica S, Cortes-Rivera C, Otero C, et al
    Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.
    Crit Care Med. 2019;47:942-950.
    PubMed     Abstract available


  147. SCHLOSSER K, Wang JP, Dos Santos C, Walley KR, et al
    Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.
    Crit Care Med. 2019;47:918-925.
    PubMed     Abstract available


    June 2019
  148. ANTCLIFFE DB, Gordon AC
    Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock?
    Crit Care Med. 2019 Jun 3. doi: 10.1097/CCM.0000000000003833.
    PubMed    


  149. DORNAS W
    Damaging Effects of Oxygen in Induced Sepsis-Like Condition.
    Crit Care Med. 2019;47:e535-e536.
    PubMed    


  150. JOFFE AR, deCaen A
    Not Enough Evidence to Use Plasma Exchange for Sepsis or Thrombocytopenia-Associated Multiple Organ Failure in Children.
    Crit Care Med. 2019;47:e533-e534.
    PubMed    


  151. BERG RMG, Asghar MS
    Luxury Perfusion in Patients With Sepsis?
    Crit Care Med. 2019;47:e533.
    PubMed    


  152. LI S, Wang S, Priyanka P, Kellum JA, et al
    Acute Kidney Injury in Critically Ill Patients After Noncardiac Major Surgery: Early Versus Late Onset.
    Crit Care Med. 2019;47:e437-e444.
    PubMed     Abstract available


    May 2019
  153. RHEE C, Wang R, Zhang Z, Fram D, et al
    Epidemiology of Hospital-Onset Versus Community-Onset Sepsis in U.S. Hospitals and Association With Mortality: A Retrospective Analysis Using Electronic Clinical Data.
    Crit Care Med. 2019 May 24. doi: 10.1097/CCM.0000000000003817.
    PubMed     Abstract available


  154. GINESTRA JC, Giannini HM, Schweickert WD, Meadows L, et al
    Clinician Perception of a Machine Learning-Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock.
    Crit Care Med. 2019 May 24. doi: 10.1097/CCM.0000000000003803.
    PubMed     Abstract available


  155. CROUSER ED, Parrillo JE, Seymour CW, Angus DC, et al
    Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients.
    Crit Care Med. 2019 May 17. doi: 10.1097/CCM.0000000000003799.
    PubMed     Abstract available


  156. DESAI R, Hanna B, Singh S, Omar A, et al
    Trends and Outcomes in Sepsis Hospitalizations With and Without Atrial Fibrillation: A Nationwide Inpatient Analysis.
    Crit Care Med. 2019 May 13. doi: 10.1097/CCM.0000000000003806.
    PubMed     Abstract available


  157. SIMPSON SQ
    Sepsis Epidemiology From Administrative Data: Going, Going....
    Crit Care Med. 2019;47:739-740.
    PubMed    


  158. CROUSER ED, Caldwell CC, Hotchkiss RS
    What Is the Skinny on Obesity During Sepsis?
    Crit Care Med. 2019;47:735-736.
    PubMed    


  159. CAWCUTT KA, Kalil AC
    Saved From Sepsis: Can Immunotherapy Improve Acute and Postacute Outcomes?
    Crit Care Med. 2019;47:733-735.
    PubMed    


  160. WOOLUM JA, Flannery AH
    The authors reply.
    Crit Care Med. 2019;47:e435-e436.
    PubMed    


  161. PATEL JJ, Bergl P
    Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.
    Crit Care Med. 2019;47:e434-e435.
    PubMed    


  162. MORELLI A, Sanfilippo F, Rehberg S, Ertmer C, et al
    The authors reply.
    Crit Care Med. 2019;47:e432-e433.
    PubMed    


  163. PETITJEANS F, Leroy S, Geloen A, Pichot C, et al
    On the Right Track, Finally?
    Crit Care Med. 2019;47:e431-e432.
    PubMed    


  164. ROSSAINT J, Zarbock A
    A Novel Approach for the Targeted Inhibition of Platelet Activation-Separating the Good From the Bad.
    Crit Care Med. 2019;47:741-743.
    PubMed    


  165. GRUMAZ S, Grumaz C, Vainshtein Y, Stevens P, et al
    Enhanced Performance of Next-Generation Sequencing Diagnostics Compared With Standard of Care Microbiological Diagnostics in Patients Suffering From Septic Shock.
    Crit Care Med. 2019;47:e394-e402.
    PubMed     Abstract available


    April 2019
  166. CORL KA, Prodromou M, Merchant RC, Gareen I, et al
    The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study.
    Crit Care Med. 2019 Apr 12. doi: 10.1097/CCM.0000000000003779.
    PubMed     Abstract available


  167. HIGGINS AM, Peake SL, Bellomo R, Cooper DJ, et al
    Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.
    Crit Care Med. 2019 Apr 8. doi: 10.1097/CCM.0000000000003762.
    PubMed     Abstract available


  168. WIEDERMANN CJ
    Hypoalbuminemia and the Risk of Acute Kidney Injury in Sepsis.
    Crit Care Med. 2019;47:e377-e378.
    PubMed    


  169. ARGENT AC
    Readmission After Hospitalization for Pediatric Severe Sepsis-Data From a U.S. Database.
    Crit Care Med. 2019;47:612-613.
    PubMed    


  170. BAUER PR
    The Sicker Are Sicker: A Tale of Late Outcome After Sepsis.
    Crit Care Med. 2019;47:610-611.
    PubMed    


  171. HURST SD, Coopersmith CM
    Can We Compare Sepsis Outcomes on a Hospital Level If Documentation Is Variable (or Inaccurate)?
    Crit Care Med. 2019;47:599-600.
    PubMed    


  172. FISHER J, Linder A, Caironi P, Russell JA, et al
    The authors reply.
    Crit Care Med. 2019;47:e378-e379.
    PubMed    


  173. MENARD CE, Kumar A, Houston DS, Turgeon AF, et al
    Evolution and Impact of Thrombocytopenia in Septic Shock: A Retrospective Cohort Study.
    Crit Care Med. 2019;47:558-565.
    PubMed     Abstract available


  174. LEIJTE GP, Kiers D, van der Heijden W, Jansen A, et al
    Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
    Crit Care Med. 2019;47:508-516.
    PubMed     Abstract available


    March 2019
  175. KOHOUTOVA M, Horak J, Jarkovska D, Martinkova V, et al
    Vagus Nerve Stimulation Attenuates Multiple Organ Dysfunction in Resuscitated Porcine Progressive Sepsis.
    Crit Care Med. 2019 Mar 25. doi: 10.1097/CCM.0000000000003714.
    PubMed     Abstract available


  176. BOURCIER S, Hindlet P, Guidet B, Dechartres A, et al
    Reporting of Organ Support Outcomes in Septic Shock Randomized Controlled Trials: A Methodologic Review-The Sepsis Organ Support Study.
    Crit Care Med. 2019 Mar 19. doi: 10.1097/CCM.0000000000003746.
    PubMed     Abstract available


  177. CHANG EY, Stevens ES, Bakinde N
    Sepsis in Non-ICU Patients: A Call for Guideline Reassessment.
    Crit Care Med. 2019;47:e266.
    PubMed    


  178. SKLAR MC, Dos Santos CC, Lawler PR
    Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Survival in Sepsis: Causal Inference Through Human Genetics.
    Crit Care Med. 2019;47:489-491.
    PubMed    


  179. SIMPSON SQ
    Surveillance for Adult Sepsis Events: An Idea Whose Time Has Come.
    Crit Care Med. 2019;47:467-468.
    PubMed    


  180. RHEE C, Zhang Z, Kadri SS, Murphy DJ, et al
    Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria.
    Crit Care Med. 2019;47:307-314.
    PubMed     Abstract available


  181. KELLY BJ, Lautenbach E, Han JH
    The authors reply.
    Crit Care Med. 2019;47:e275-e276.
    PubMed    


  182. PATNAIK R, Gurjar M
    Is Combined Biomarkers a Future Tool for Early Prediction of Mortality Among Septic Patients?
    Crit Care Med. 2019;47:e275.
    PubMed    


  183. REDFERN OC, Smith GB, Prytherch DR, Meredith P, et al
    The authors reply.
    Crit Care Med. 2019;47:e266-e267.
    PubMed    


    February 2019
  184. PEPPER DJ, Demirkale CY, Sun J, Rhee C, et al
    Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients.
    Crit Care Med. 2019 Feb 14. doi: 10.1097/CCM.0000000000003692.
    PubMed     Abstract available


  185. KUSHIMOTO S, Abe T, Ogura H, Shiraishi A, et al
    Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsi
    Crit Care Med. 2019 Feb 14. doi: 10.1097/CCM.0000000000003688.
    PubMed     Abstract available


  186. HOTCHKISS RS, Colston E, Yende S, Angus DC, et al
    Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 (BMS-936559).
    Crit Care Med. 2019 Feb 8. doi: 10.1097/CCM.0000000000003685.
    PubMed     Abstract available


  187. ILKO SA, Vakkalanka JP, Ahmed A, Harland KK, et al
    Central Venous Access Capability and Critical Care Telemedicine Decreases Inter-Hospital Transfer Among Severe Sepsis Patients: A Mixed Methods Design.
    Crit Care Med. 2019 Feb 5. doi: 10.1097/CCM.0000000000003686.
    PubMed     Abstract available


  188. GRANJA T, Korner A, Gluck C, Hohmann JD, et al
    Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study.
    Crit Care Med. 2019 Feb 5. doi: 10.1097/CCM.0000000000003682.
    PubMed     Abstract available


  189. KRAFT BD, Chen L, Suliman HB, Piantadosi CA, et al
    Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis.
    Crit Care Med. 2019 Feb 5. doi: 10.1097/CCM.0000000000003681.
    PubMed     Abstract available


  190. BOSCH NA, Cohen DM, Walkey AJ
    Risk Factors for New-Onset Atrial Fibrillation in Patients With Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2019;47:280-287.
    PubMed     Abstract available


  191. DE GROOTH HJ, Girbes AR
    Corticosteroids in Sepsis: Clouded by Heterogeneity.
    Crit Care Med. 2019;47:e163-e164.
    PubMed    


  192. SCHURR JW, McLaughlin KC, Szumita PM
    Defining the Role of Corticosteroids in Sepsis: Adjunctive Therapy for Shock Reversal.
    Crit Care Med. 2019;47:e157-e158.
    PubMed    


  193. MARTIN B, Bennett TD
    Sepsis Computable Phenotypes in the Service of Observational Research.
    Crit Care Med. 2019;47:303-305.
    PubMed    


  194. OCZKOWSKI SJ, Rochwerg B, Alhazzani W, Siemieniuk RAC, et al
    The authors reply.
    Crit Care Med. 2019;47:e158-e159.
    PubMed    


  195. WOOLUM JA, Flannery AH
    The authors reply.
    Crit Care Med. 2019;47:e154.
    PubMed    


  196. OLANIPEKUN TO, Bakinde N, Effoe VS, Snyder R, et al
    Further Considerations on the Benefits of Thiamine Administration in Patients With Septic Shock.
    Crit Care Med. 2019;47:e153-e154.
    PubMed    


  197. MORELLI A, Sanfilippo F, Arnemann P, Hessler M, et al
    The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.
    Crit Care Med. 2019;47:e89-e95.
    PubMed     Abstract available


    January 2019
  198. KIM J, Kim YA, Hwangbo B, Kim MJ, et al
    Effect of Antihypertensive Medications on Sepsis-Related Outcomes: A Population-Based Cohort Study.
    Crit Care Med. 2019 Jan 24. doi: 10.1097/CCM.0000000000003654.
    PubMed     Abstract available


  199. CARLTON EF, Kohne JG, Shankar-Hari M, Prescott HC, et al
    Readmission Diagnoses After Pediatric Severe Sepsis Hospitalization.
    Crit Care Med. 2019 Jan 22. doi: 10.1097/CCM.0000000000003646.
    PubMed     Abstract available


  200. GARDNER AK, Ghita GL, Wang Z, Ozrazgat-Baslanti T, et al
    The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
    Crit Care Med. 2019 Jan 18. doi: 10.1097/CCM.0000000000003655.
    PubMed     Abstract available


  201. DAHABA AA
    Can We Improve Long-Term Survival of Patients With Severe Sepsis at ICU Admission?
    Crit Care Med. 2019;47:e71.
    PubMed    


  202. WALKEY AJ
    Exploring the Pathways Revealed by International Sepsis Benchmarking.
    Crit Care Med. 2019;47:135-137.
    PubMed    


  203. LANKADEVA YR, Kosaka J, Iguchi N, Evans RG, et al
    Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury.
    Crit Care Med. 2019;47:e36-e43.
    PubMed     Abstract available


  204. LU C, Liu Q, Yuan H, Wang L, et al
    Implementation of the Smart Use of Antibiotics Program to Reduce Unnecessary Antibiotic Use in a Neonatal ICU: A Prospective Interrupted Time-Series Study in a Developing Country.
    Crit Care Med. 2019;47:e1-e7.
    PubMed     Abstract available


    December 2018
  205. BARBASH IJ, Davis B, Kahn JM
    National Performance on the Medicare SEP-1 Sepsis Quality Measure.
    Crit Care Med. 2018 Dec 21. doi: 10.1097/CCM.0000000000003613.
    PubMed     Abstract available


  206. KLOMPAS M, Rhee C
    Current Sepsis Mandates Are Overly Prescriptive, and Some Aspects May Be Harmful.
    Crit Care Med. 2018 Dec 4. doi: 10.1097/CCM.0000000000003579.
    PubMed    


  207. VARGAS M, Servillo G
    The End of Corticosteroid in Sepsis: Fragile Results From Fragile Trials.
    Crit Care Med. 2018;46:e1228.
    PubMed    


  208. GOODWIN AJ
    Can Serial Quick Sequential (Sepsis-Related) Organ Failure Assessment Measurement Aid in Sepsis Identification and Triage Decisions?
    Crit Care Med. 2018;46:2046-2048.
    PubMed    


  209. KEMPKER JA, Martin GS
    Severity and Timing of Onset Drive Economic Costs and Clinical Outcomes With Sepsis.
    Crit Care Med. 2018;46:2043-2044.
    PubMed    


    November 2018
  210. RHEE C, Jentzsch MS, Kadri SS, Seymour CW, et al
    Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons.
    Crit Care Med. 2018 Nov 13. doi: 10.1097/CCM.0000000000003554.
    PubMed     Abstract available


  211. MEHTA NM
    Nutritional Status and Outcomes in Pediatric Severe Sepsis-Size Matters.
    Crit Care Med. 2018;46:1886-1887.
    PubMed    


  212. CARLTON EF, Prescott HC
    Variation in Sepsis-Related Mortality; Implications for Performance Improvement.
    Crit Care Med. 2018;46:1871-1873.
    PubMed    


  213. WALLEY KR, Boyd JH, Kong HJ, Russell JA, et al
    Low Low-Density Lipoprotein Levels Are Associated With, But Do Not Causally Contribute to, Increased Mortality in Sepsis.
    Crit Care Med. 2018 Nov 1. doi: 10.1097/CCM.0000000000003551.
    PubMed     Abstract available


    October 2018
  214. LINDELL RB, Nishisaki A, Weiss SL, Balamuth F, et al
    Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database.
    Crit Care Med. 2018 Oct 31. doi: 10.1097/CCM.0000000000003541.
    PubMed     Abstract available


  215. CHUNG KP, Chen GY, Chuang TY, Huang YT, et al
    Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study.
    Crit Care Med. 2018 Oct 30. doi: 10.1097/CCM.0000000000003517.
    PubMed     Abstract available


  216. LAI CC, Wang YH, Wang CY, Wang HC, et al
    Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers.
    Crit Care Med. 2018 Oct 9. doi: 10.1097/CCM.0000000000003475.
    PubMed     Abstract available


  217. SRINIVASAN V
    Probiotics in Pediatric Severe Sepsis: The Time Has Come to Trust Our 'Gut'!
    Crit Care Med. 2018;46:1707-1708.
    PubMed    


  218. MARIK PE, Farkas JD
    The Changing Paradigm of Sepsis: Early Diagnosis, Early Antibiotics, Early Pressors, and Early Adjuvant Treatment.
    Crit Care Med. 2018;46:1690-1692.
    PubMed    


  219. KANJILAL S, Kalil AC, Klompas M
    What Is the Best Treatment for Vancomycin-Resistant Enterococcal Bloodstream Infections?
    Crit Care Med. 2018;46:1700-1703.
    PubMed    


    September 2018
  220. RANZANI OT, Shankar-Hari M, Harrison DA, Rabello LS, et al
    A Comparison of Mortality From Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis-Specific Patient Characteristics.
    Crit Care Med. 2018 Sep 20. doi: 10.1097/CCM.0000000000003438.
    PubMed     Abstract available


  221. HASSLACHER J, Joannidis M
    Secretoneurin in Sepsis: Is It the Brain?
    Crit Care Med. 2018;46:e959.
    PubMed    


  222. CLAXTON AJ, Thompson-Leduc P, Kirson NY, Rice B, et al
    Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis: Author Correction.
    Crit Care Med. 2018;46:1560.
    PubMed    


  223. EVANS LE
    Progress Toward "Ruling Out" Sepsis.
    Crit Care Med. 2018;46:1553-1554.
    PubMed    


  224. LEWIS AJ, Lee JS, Rosengart MR
    Translational Sepsis Research: Spanning the Divide.
    Crit Care Med. 2018;46:1497-1505.
    PubMed     Abstract available


    August 2018
  225. REDFERN OC, Smith GB, Prytherch DR, Meredith P, et al
    A Comparison of the Quick Sequential (Sepsis-Related) Organ Failure Assessment Score and the National Early Warning Score in Non-ICU Patients With/Without Infection.
    Crit Care Med. 2018 Aug 20. doi: 10.1097/CCM.0000000000003359.
    PubMed     Abstract available


  226. KIEVLAN DR, Zhang LA, Chang CH, Angus DC, et al
    Evaluation of Repeated Quick Sepsis-Related Organ Failure Assessment Measurements Among Patients With Suspected Infection.
    Crit Care Med. 2018 Aug 20. doi: 10.1097/CCM.0000000000003360.
    PubMed     Abstract available


  227. KIDSON KM, Henderson WR, Hutcheon JA
    Case Fatality and Adverse Outcomes Are Reduced in Pregnant Women With Severe Sepsis or Septic Shock Compared With Age-Matched Comorbid-Matched Nonpregnant Women.
    Crit Care Med. 2018 Aug 9. doi: 10.1097/CCM.0000000000003348.
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  228. IRVING SY, Daly B, Verger J, Typpo KV, et al
    The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study.
    Crit Care Med. 2018 Aug 7. doi: 10.1097/CCM.0000000000003351.
    PubMed     Abstract available


  229. HANIFFA R, Beane A, Dondorp AM
    Is the Tail Wagging the Dog in Sepsis?
    Crit Care Med. 2018;46:e818.
    PubMed    


  230. PANNU S, Crouser ED
    Blue Light Illuminates a Novel Sepsis Treatment.
    Crit Care Med. 2018;46:1381-1382.
    PubMed    


  231. SIMPSON SQ
    Sepsis-The "Gift" That Keeps on Giving, Regardless of Age.
    Crit Care Med. 2018;46:1378-1380.
    PubMed    


  232. GAUGHAN J
    Sepsis Redefined...Again.
    Crit Care Med. 2018;46:1378.
    PubMed    


    July 2018
  233. PAOLI CJ, Reynolds MA, Sinha M, Gitlin M, et al
    Epidemiology and Costs of Sepsis in the United States-An Analysis Based on Timing of Diagnosis and Severity Level.
    Crit Care Med. 2018 Jul 25. doi: 10.1097/CCM.0000000000003342.
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  234. HATFIELD KM, Dantes RB, Baggs J, Sapiano MRP, et al
    Assessing Variability in Hospital-Level Mortality Among U.S. Medicare Beneficiaries With Hospitalizations for Severe Sepsis and Septic Shock.
    Crit Care Med. 2018 Jul 17. doi: 10.1097/CCM.0000000000003324.
    PubMed     Abstract available


  235. WU J, Han B, Fanelli V, Wen X, et al
    Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome.
    Crit Care Med. 2018 Jul 2. doi: 10.1097/CCM.0000000000003265.
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  236. ROCHWERG B, Oczkowski SJ, Siemieniuk RAC, Agoritsas T, et al
    Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis.
    Crit Care Med. 2018 Jul 2. doi: 10.1097/CCM.0000000000003262.
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  237. THAMM K, Schrimpf C, Retzlaff J, Idowu TO, et al
    Molecular Regulation of Acute Tie2 Suppression in Sepsis.
    Crit Care Med. 2018 Jul 2. doi: 10.1097/CCM.0000000000003269.
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  238. AKYOL BEYOGLU C, Koksal GM, Esquinas AM
    Association Between PaCO2 and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department-Is PaCO2 a Predictive Parameter for Hospital Discharge?
    Crit Care Med. 2018;46:e718.
    PubMed    


  239. GERLACH AT
    Sepsis Biomarkers...The Long and Winding Road.
    Crit Care Med. 2018;46:1194-1195.
    PubMed    


  240. KELLY BJ, Lautenbach E, Nachamkin I, Coffin SE, et al
    Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis.
    Crit Care Med. 2018;46:1106-1113.
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    June 2018
  241. RHEE C, Filbin MR, Massaro AF, Bulger AL, et al
    Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
    Crit Care Med. 2018 Jun 28. doi: 10.1097/CCM.0000000000003261.
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  242. COOPERSMITH CM, De Backer D, Deutschman CS, Ferrer R, et al
    Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock.
    Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003225.
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  243. ANGURANA SK, Bansal A, Singhi S, Aggarwal R, et al
    Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial.
    Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003279.
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  244. CHUANG YC, Lin HY, Chen PY, Lin CY, et al
    Survival of Patients With Vancomycin-Resistant Enterococcus faecium Bacteremia Treated With Conventional or High Doses of Daptomycin or Linezolid Is Associated With the Rate of Bacterial Clearance.
    Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003264.
    PubMed     Abstract available


  245. LEVY MM, Evans LE, Rhodes A
    The Surviving Sepsis Campaign Bundle: 2018 Update.
    Crit Care Med. 2018;46:997-1000.
    PubMed    


  246. JACOBS MC, Wiersinga WJ
    Interleukin-34: A New Player in the Sepsis Arena.
    Crit Care Med. 2018;46:1032-1033.
    PubMed    


  247. PROWLE JR
    Renal Blood Flow Measurement in Early Clinical Sepsis-Can You Catch a Shadow?
    Crit Care Med. 2018;46:1028-1030.
    PubMed    


  248. SHANKAR-HARI M, Rubenfeld GD
    Race, Ethnicity, and Sepsis: Beyond Adjusted Odds Ratios.
    Crit Care Med. 2018;46:1009-1010.
    PubMed    


  249. HENSLEY MK, Prescott HC
    Bad Brains, Bad Outcomes: Acute Neurologic Dysfunction and Late Death After Sepsis.
    Crit Care Med. 2018;46:1001-1002.
    PubMed    


    May 2018
  250. MCHALE TM, Garciarena CD, Fagan RP, Smith SGJ, et al
    Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis.
    Crit Care Med. 2018 May 18. doi: 10.1097/CCM.0000000000003219.
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  251. LIMA A, van Rooij T, Ergin B, Sorelli M, et al
    Dynamic Contrast-Enhanced Ultrasound Identifies Microcirculatory Alterations in Sepsis-Induced Acute Kidney Injury.
    Crit Care Med. 2018 May 15. doi: 10.1097/CCM.0000000000003209.
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  252. ESTENSSORO E, Kanoore Edul VS, Loudet CI, Osatnik J, et al
    Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina.
    Crit Care Med. 2018 May 8. doi: 10.1097/CCM.0000000000003208.
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  253. MEARELLI F, Fiotti N, Giansante C, Casarsa C, et al
    Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study.
    Crit Care Med. 2018 May 7. doi: 10.1097/CCM.0000000000003206.
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  254. ABU-KAF H, Mizrakli Y, Novack V, Dreiher J, et al
    Long-Term Survival of Young Patients Surviving ICU Admission With Severe Sepsis.
    Crit Care Med. 2018 May 7. doi: 10.1097/CCM.0000000000003205.
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  255. LEWIS AJ, Zhang X, Griepentrog JE, Yuan D, et al
    Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis.
    Crit Care Med. 2018 May 4. doi: 10.1097/CCM.0000000000003190.
    PubMed     Abstract available


  256. KALIL AC, Van Schooneveld TC
    Is Procalcitonin-Guided Therapy Associated With Beneficial Outcomes in Critically Ill Patients With Sepsis?
    Crit Care Med. 2018;46:811-812.
    PubMed    


  257. STAUNTON O, Staunton C
    The Urgency of Now: Attacking the Sepsis Crisis.
    Crit Care Med. 2018;46:809-810.
    PubMed    


    April 2018
  258. MATHIEU C, Desrois M, Kober F, Lalevee N, et al
    Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study.
    Crit Care Med. 2018 Apr 7. doi: 10.1097/CCM.0000000000003146.
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  259. MASSE MH, Richard MA, D'Aragon F, St-Arnaud C, et al
    Early Evidence of Sepsis-Associated Hyperperfusion-A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects.
    Crit Care Med. 2018 Apr 6. doi: 10.1097/CCM.0000000000003147.
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  260. YOON J, Kym D, Hur J, Kim Y, et al
    Comparative Usefulness of Sepsis-3, Burn Sepsis, and Conventional Sepsis Criteria in Patients With Major Burns.
    Crit Care Med. 2018 Apr 3. doi: 10.1097/CCM.0000000000003144.
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  261. CROUSER ED
    Sepsis-Induced Renal Failure: Ischemia or Toxemia?
    Crit Care Med. 2018;46:658-660.
    PubMed    


  262. KLOMPAS M, Rhee C
    Missed Opportunities for Better Sepsis Care or Misplaced Blame? Deconstructing Patients' Encounters in the Week Before Sepsis Hospitalizations.
    Crit Care Med. 2018;46:644-645.
    PubMed    


  263. NATHANSON BH
    First, Most, and Best: The Implications of Delays in Implementing Surviving Sepsis Campaign Guidelines.
    Crit Care Med. 2018;46:642-643.
    PubMed    


  264. SAVEL RH, Shiloh AL, Simon RJ, Kupfer Y, et al
    Using Big Data to See the Big Picture in Sepsis.
    Crit Care Med. 2018;46:640-641.
    PubMed    


    March 2018
  265. SKORUP P, Maudsdotter L, Tano E, Lipcsey M, et al
    Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model.
    Crit Care Med. 2018 Mar 27. doi: 10.1097/CCM.0000000000003139.
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  266. SWEENEY TE, Azad TD, Donato M, Haynes WA, et al
    Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.
    Crit Care Med. 2018 Mar 13. doi: 10.1097/CCM.0000000000003084.
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  267. LEE SH, Hsu TC, Lee MG, Chao CC, et al
    Nationwide Trend of Sepsis: A Comparison Among Octogenarians, Elderly, and Young Adults.
    Crit Care Med. 2018 Mar 10. doi: 10.1097/CCM.0000000000003085.
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  268. SCHEER CS, Kuhn SO, Rehberg S
    Sepsis-3 Is a Positive Evolution in Discrimination Between Septic and Nonseptic Patients As Well As Sepsis Entities, Not a Step Backward.
    Crit Care Med. 2018;46:e273.
    PubMed    


  269. MACHADO FR, Azevedo LCP
    Sepsis: A Threat That Needs a Global Solution.
    Crit Care Med. 2018;46:454-459.
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  270. MEYER N, Harhay MO, Small DS, Prescott HC, et al
    Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis.
    Crit Care Med. 2018;46:354-360.
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    February 2018
  271. ROSJO H, Masson S, Caironi P, Stridsberg M, et al
    Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.
    Crit Care Med. 2018 Feb 23. doi: 10.1097/CCM.0000000000003050.
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  272. CHAUDHARY NS, Donnelly JP, Wang HE
    Racial Differences in Sepsis Mortality at U.S. Academic Medical Center-Affiliated Hospitals.
    Crit Care Med. 2018 Feb 12. doi: 10.1097/CCM.0000000000003020.
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  273. SCHULER A, Wulf DA, Lu Y, Iwashyna TJ, et al
    The Impact of Acute Organ Dysfunction on Long-Term Survival in Sepsis.
    Crit Care Med. 2018 Feb 9. doi: 10.1097/CCM.0000000000003023.
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  274. RYOO SM, Lee J, Lee YS, Lee JH, et al
    Lactate Level Versus Lactate Clearance for Predicting Mortality in Patients With Septic Shock Defined by Sepsis-3.
    Crit Care Med. 2018 Feb 9. doi: 10.1097/CCM.0000000000003030.
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  275. PRESCOTT HC, Cope TM, Gesten FC, Ledneva TA, et al
    Reporting of Sepsis Cases for Performance Measurement Versus for Reimbursement in New York State.
    Crit Care Med. 2018 Feb 5. doi: 10.1097/CCM.0000000000003005.
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  276. MORLEY PT
    Early Fluid Management in Sepsis: Yes.
    Crit Care Med. 2018;46:327-328.
    PubMed    


    January 2018
  277. LIN X, Luo H, Yan X, Song Z, et al
    Interleukin-34 Ameliorates Survival and Bacterial Clearance in Polymicrobial Sepsis.
    Crit Care Med. 2018 Jan 30. doi: 10.1097/CCM.0000000000003017.
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  278. CHERRUAULT M, Le Goff M, Tamburini J, Pene F, et al
    Urgent Chemotherapy in Sepsis-Like Shock Related to Hematologic Malignancies.
    Crit Care Med. 2018 Jan 25. doi: 10.1097/CCM.0000000000002990.
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  279. LYONS PG, Micek ST, Hampton N, Kollef MH, et al
    Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality.
    Crit Care Med. 2018 Jan 25. doi: 10.1097/CCM.0000000000002997.
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  280. FAISAL M, Scally A, Richardson D, Beatson K, et al
    Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient's First Electronically Recorded Vital Signs and Blood Test Results.
    Crit Care Med. 2018 Jan 24. doi: 10.1097/CCM.0000000000002967.
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  281. LEWIS AJ, Griepentrog JE, Zhang X, Angus DC, et al
    Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis: A Murine Trial.
    Crit Care Med. 2018 Jan 23. doi: 10.1097/CCM.0000000000003004.
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  282. LIU VX, Escobar GJ, Chaudhary R, Prescott HC, et al
    Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization.
    Crit Care Med. 2018 Jan 5. doi: 10.1097/CCM.0000000000002960.
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  283. KURODA K, Wake H, Mori S, Hinotsu S, et al
    Decrease in Histidine-Rich Glycoprotein as a Novel Biomarker to Predict Sepsis Among Systemic Inflammatory Response Syndrome.
    Crit Care Med. 2018 Jan 4. doi: 10.1097/CCM.0000000000002947.
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  284. JOHNSON AEW, Aboab J, Raffa JD, Pollard TJ, et al
    A Comparative Analysis of Sepsis Identification Methods in an Electronic Database.
    Crit Care Med. 2018 Jan 4. doi: 10.1097/CCM.0000000000002965.
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  285. PRUINELLI L, Westra BL, Yadav P, Hoff A, et al
    Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock.
    Crit Care Med. 2018 Jan 2. doi: 10.1097/CCM.0000000000002949.
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  286. DOTSON B
    Calcium Channel Blockers and Sepsis Outcomes.
    Crit Care Med. 2018;46:e97-e98.
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  287. DELMAS B, Jabot J, Chanareille P, Ferdynus C, et al
    Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions.
    Crit Care Med. 2018;46:93-99.
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  288. LANKADEVA YR, Kosaka J, Evans RG, Bellomo R, et al
    Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic Acute Kidney Injury.
    Crit Care Med. 2018;46:e41-e48.
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  289. TYLER PD, Stone DJ, Geisler BP, McLennan S, et al
    Racial and Geographic Disparities in Interhospital ICU Transfers.
    Crit Care Med. 2018;46:e76-e80.
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  290. MIANO TA, Lam S
    The Healthy User Effect in Studies of Statins in the Critically Ill.
    Crit Care Med. 2018;46:e95.
    PubMed    


  291. KRAMER AA
    A Self-Fulfilling Hypothesis.
    Crit Care Med. 2018;46:158-159.
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    December 2017
  292. NEMATI S, Holder A, Razmi F, Stanley MD, et al
    An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU.
    Crit Care Med. 2017 Dec 26. doi: 10.1097/CCM.0000000000002936.
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  293. IANKOVA I, Thompson-Leduc P, Kirson NY, Rice B, et al
    Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2017 Dec 21. doi: 10.1097/CCM.0000000000002928.
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  294. SEMERARO F, Colucci M, Caironi P, Masson S, et al
    Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis.
    Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002919.
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  295. ROBERTS BW, Mohr NM, Ablordeppey E, Drewry AM, et al
    Association Between Partial Pressure of Arterial Carbon Dioxide and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department.
    Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002918.
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  296. VALLEY TS, Nallamothu BK, Heung M, Iwashyna TJ, et al
    Hospital Variation in Renal Replacement Therapy for Sepsis in the United States.
    Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002878.
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  297. PHILLIPS GS, Osborn TM, Terry KM, Gesten F, et al
    The New York Sepsis Severity Score: Development of a Risk-Adjusted Severity Model for Sepsis.
    Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002824.
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  298. KIKUTANI K, Ohshimo S, Shime N
    Potential Confounders of Procalcitonin-Guided Antibiotic Therapy for Sepsis.
    Crit Care Med. 2017;45:e1310-e1311.
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  299. KRAMER AH
    Is A Hemoglobin Concentration As Low As 7 g/dL Adequate For All Critically Ill Patients With Sepsis? Legitimate Doubts Remain!
    Crit Care Med. 2017;45:2101-2102.
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  300. ERWIN BL, Denaburg MA, Barker AB, McArdle PJ, et al
    Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors.
    Crit Care Med. 2017;45:e1226-e1232.
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  301. DU W, Liu D, Long Y, Wang X, et al
    The beta-Blocker Esmolol Restores the Vascular Waterfall Phenomenon After Acute Endotoxemia.
    Crit Care Med. 2017;45:e1247-e1253.
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  302. JAMME M, Daviaud F, Charpentier J, Marin N, et al
    Time Course of Septic Shock in Immunocompromised and Nonimmunocompromised Patients.
    Crit Care Med. 2017;45:2031-2039.
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  303. DUPUIS C, Garrouste-Orgeas M, Bailly S, Adrie C, et al
    Effect of Transfusion on Mortality and Other Adverse Events Among Critically Ill Septic Patients: An Observational Study Using a Marginal Structural Cox Model.
    Crit Care Med. 2017;45:1972-1980.
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    November 2017
  304. LEISMAN DE, Doerfler ME, Schneider SM, Masick KD, et al
    Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock.
    Crit Care Med. 2017 Nov 3. doi: 10.1097/CCM.0000000000002834.
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  305. CASEY JD, Semler MW, Bastarache JA
    Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?
    Crit Care Med. 2017;45:1959-1960.
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  306. JAWA RS, Kew RR
    Sepsis in the Critically Ill-Does Gender Matter?
    Crit Care Med. 2017;45:1957-1959.
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  307. SPOLARICS Z
    Victims or Culprits, B Cells May Serve as Markers for Mortality Risk and Targeted Therapy in Sepsis.
    Crit Care Med. 2017;45:1951-1952.
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  308. LIU VX, Walkey AJ
    Machine Learning and Sepsis: On the Road to Revolution.
    Crit Care Med. 2017;45:1946-1947.
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  309. COQUEREL D, Chagnon F, Sainsily X, Dumont L, et al
    ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.
    Crit Care Med. 2017;45:e1139-e1148.
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  310. MOSKOWITZ A, Patel PV, Grossestreuer AV, Chase M, et al
    Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection.
    Crit Care Med. 2017;45:1813-1819.
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    October 2017
  311. STEELAND S, Van Ryckeghem S, Vandewalle J, Ballegeer M, et al
    Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
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  312. RUSH B, Tyler PD, Stone DJ, Geisler BP, et al
    Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis.
    Crit Care Med. 2017 Oct 24. doi: 10.1097/CCM.0000000000002777.
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  313. YEHYA N, Wong HR
    Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002754.
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  314. PUTHUCHEARY ZA, Sun Y, Zeng K, Vu LH, et al
    Sepsis Reduces Bone Strength Before Morphologic Changes Are Identifiable.
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    Pediatric Sepsis Endotypes Among Adults With Sepsis.
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  316. EHLENBACH WJ, Gilmore-Bykovskyi A, Repplinger MD, Westergaard RP, et al
    Sepsis Survivors Admitted to Skilled Nursing Facilities: Cognitive Impairment, Activities of Daily Living Dependence, and Survival.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002755.
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  317. MEYER NJ, Reilly JP, Anderson BJ, Palakshappa JA, et al
    Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002749.
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  318. VITORIO D, Nassar AP Jr, Caruso P
    Procalcitonin Clearance and Prognosis in Sepsis: Are There Really an Optimal Cutoff and Time Interval?
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    PubMed    


  319. PFORTMUELLER CA, Meisel C, Schefold JC
    Interpreting Immune Mediator Dysbalance in Sepsis.
    Crit Care Med. 2017;45:e1094-e1095.
    PubMed    


  320. RIMAWI RH
    Bad Response or Bad Luck? A New Versus Recrudescent Sepsis Readmission.
    Crit Care Med. 2017;45:1788-1789.
    PubMed    


  321. LANSPA MJ, Morris AH
    The Importance of Clinical Context on Assessing Outcomes in Sepsis.
    Crit Care Med. 2017;45:1783-1785.
    PubMed    


  322. NUGENT KL, Coopersmith CM
    Fluid Management in Sepsis-Is There a Golden Hour (or Two)?
    Crit Care Med. 2017;45:1773-1775.
    PubMed    


  323. GRASSELLI G, Scaravilli V, Di Bella S, Biffi S, et al
    Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impact on Patients' Outcome.
    Crit Care Med. 2017;45:1726-1733.
    PubMed     Abstract available


    September 2017
  324. ANNANE D, Pastores SM, Rochwerg B, Arlt W, et al
    Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.
    Crit Care Med. 2017 Sep 21. doi: 10.1097/CCM.0000000000002737.
    PubMed     Abstract available


  325. JONES JM, Fingar KR, Miller MA, Coffey R, et al
    Racial Disparities in Sepsis-Related In-Hospital Mortality: Using a Broad Case Capture Method and Multivariate Controls for Clinical and Hospital Variables, 2004-2013.
    Crit Care Med. 2017 Sep 12. doi: 10.1097/CCM.0000000000002699.
    PubMed     Abstract available


  326. WANG HE, Jones AR, Donnelly JP
    Revised National Estimates of Emergency Department Visits for Sepsis in the United States.
    Crit Care Med. 2017;45:1443-1449.
    PubMed     Abstract available


  327. AGAROSSI A, Pintaudi G
    Antimicrobials and Progression to Septic Shock in Severe Sepsis Patients: Is Delay the Only Thing That Matters?
    Crit Care Med. 2017;45:e988-e989.
    PubMed    


  328. MARSHALL JC
    Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis.
    Crit Care Med. 2017;45:1582-1583.
    PubMed    


  329. GAUDILLIERE B, Angst MS, Hotchkiss RS
    Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!
    Crit Care Med. 2017;45:1577-1578.
    PubMed    


  330. RHEE C, Klompas M
    What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition.
    Crit Care Med. 2017;45:1569-1571.
    PubMed    


  331. DEUTSCHMAN CS
    Sepsis-3: Seeing the Entire Picture.
    Crit Care Med. 2017;45:1567-1569.
    PubMed    


  332. SPRUNG CL, Trahtemberg U
    What Definition Should We Use for Sepsis and Septic Shock?
    Crit Care Med. 2017;45:1564-1567.
    PubMed    


  333. FADEL F, Andre-Gregoire G, Gravez B, Bauvois B, et al
    Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock.
    Crit Care Med. 2017;45:e954-e962.
    PubMed     Abstract available


    August 2017
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    Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.
    Crit Care Med. 2017 Aug 11. doi: 10.1097/CCM.0000000000002649.
    PubMed     Abstract available


  335. ZHAI Q, Lai D, Cui P, Zhou R, et al
    Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway.
    Crit Care Med. 2017 Aug 10. doi: 10.1097/CCM.0000000000002646.
    PubMed     Abstract available


  336. TRAUER J, Muhi S, McBryde ES, Al Harbi SA, et al
    Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
    Crit Care Med. 2017 Aug 9. doi: 10.1097/CCM.0000000000002654.
    PubMed     Abstract available


  337. KALIL AC, Kellum JA
    Is Early Goal-Directed Therapy Harmful to Patients With Sepsis and High Disease Severity?
    Crit Care Med. 2017;45:1265-1267.
    PubMed    


    July 2017
  338. SHANKAR-HARI M, Singer M, Spencer J
    Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?
    Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002627.
    PubMed     Abstract available


  339. DEMERLE KM, Royer SC, Mikkelsen ME, Prescott HC, et al
    Readmissions for Recurrent Sepsis: New or Relapsed Infection?
    Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002626.
    PubMed     Abstract available


  340. VAN VUGHT LA, Holman R, de Jonge E, de Keizer NF, et al
    Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis.
    Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002590.
    PubMed     Abstract available


  341. CHURPEK MM, Snyder A, Sokol S, Pettit NN, et al
    Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores.
    Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002648.
    PubMed     Abstract available


  342. MACHADO FR, Ferreira EM, Sousa JL, Silva C, et al
    Quality Improvement Initiatives in Sepsis in an Emerging Country: Does the Institution's Main Source of Income Influence the Results? An Analysis of 21,103 Patients.
    Crit Care Med. 2017 Jul 6. doi: 10.1097/CCM.0000000000002585.
    PubMed     Abstract available


  343. NI CHEALLAIGH C, Sheedy FJ
    Shields Up-Systemic Protection Provided by microRNA-21 During Sepsis?
    Crit Care Med. 2017;45:1261-1263.
    PubMed    


  344. MARRARO GA, Genovese U, Spada C, Piga MA, et al
    Can the Treatment Approach of Sepsis With Balanced Crystalloid Fluids Translate Into Therapy for Acute Respiratory Distress Syndrome if Considered as "Lung-Limited Sepsis"?
    Crit Care Med. 2017;45:1246-1248.
    PubMed    


  345. PRESCOTT HC, Donnelly JP
    Penalizing Readmissions After Sepsis Could Do More Harm Than Good.
    Crit Care Med. 2017;45:1243-1244.
    PubMed    


    June 2017
  346. LEISMAN DE, Goldman C, Doerfler ME, Masick KD, et al
    Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort.
    Crit Care Med. 2017 Jun 30. doi: 10.1097/CCM.0000000000002574.
    PubMed     Abstract available


  347. LEE CC, Lee MG, Lee WC, Lai CC, et al
    Preadmission Use of Calcium Channel Blocking Agents Is Associated With Improved Outcomes in Patients With Sepsis: A Population-Based Propensity Score-Matched Cohort Study.
    Crit Care Med. 2017 Jun 27. doi: 10.1097/CCM.0000000000002550.
    PubMed     Abstract available


  348. HE X, Su F, Xie K, Taccone FS, et al
    Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis.
    Crit Care Med. 2017 Jun 14. doi: 10.1097/CCM.0000000000002524.
    PubMed     Abstract available


  349. LEISMAN DE, Sethna CB
    Renin-Angiotensin-Aldosterone System Blockade Use in Sepsis Patients: Did It Impact Renal Outcomes?
    Crit Care Med. 2017;45:e624.
    PubMed    


  350. GAINES S, Alverdy JC
    Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.
    Crit Care Med. 2017;45:1106-1107.
    PubMed    


  351. FRAIMOW HS
    Safe at First, But Not Reaching Second: Implications of Delayed Second Doses of Antimicrobials in Patients Presenting to Emergency Departments With Sepsis.
    Crit Care Med. 2017;45:1097-1098.
    PubMed    


  352. DAVIS AL, Carcillo JA, Aneja RK, Deymann AJ, et al
    American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock.
    Crit Care Med. 2017;45:1061-1093.
    PubMed     Abstract available


  353. PELTAN ID, Mitchell KH, Rudd KE, Mann BA, et al
    Physician Variation in Time to Antimicrobial Treatment for Septic Patients Presenting to the Emergency Department.
    Crit Care Med. 2017;45:1011-1018.
    PubMed     Abstract available


  354. HENNING DJ, Carey JR, Oedorf K, Day DE, et al
    The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock.
    Crit Care Med. 2017;45:e575-e582.
    PubMed     Abstract available


  355. RUSSELL JA, Lee T, Singer J, Boyd JH, et al
    The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.
    Crit Care Med. 2017;45:940-948.
    PubMed     Abstract available


  356. TERRASINI N, Lionetti V
    Exosomes in Critical Illness.
    Crit Care Med. 2017;45:1054-1060.
    PubMed     Abstract available


    May 2017
  357. STERLING SA, Puskarich MA, Glass AF, Guirgis F, et al
    The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
    Crit Care Med. 2017 May 24. doi: 10.1097/CCM.0000000000002512.
    PubMed     Abstract available


  358. STANA F, Vujovic M, Mayaki D, Leduc-Gaudet JP, et al
    Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.
    Crit Care Med. 2017 May 22. doi: 10.1097/CCM.0000000000002520.
    PubMed     Abstract available


  359. DEUTSCHMAN CS
    "Defining" Sepsis: Moving Toward Measuring the "Dysregulated Host Response".
    Crit Care Med. 2017;45:927-930.
    PubMed    


  360. MARIK PE
    Glucocorticosteroids as Adjunctive Therapy for Acute Respiratory Distress Syndrome and Sepsis? Yes, But Not as Monotherapy.
    Crit Care Med. 2017;45:910-911.
    PubMed    


  361. LEVY MM
    Antibiotics in Sepsis: The New Frontier.
    Crit Care Med. 2017;45:907-908.
    PubMed    


  362. JUNG B, Mahul M, Breilh D, Legeron R, et al
    Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under- and Overdosing.
    Crit Care Med. 2017;45:e470-e478.
    PubMed     Abstract available


  363. BERGAMIN FS, Almeida JP, Landoni G, Galas FRBG, et al
    Liberal Versus Restrictive Transfusion Strategy in Critically Ill Oncologic Patients: The Transfusion Requirements in Critically Ill Oncologic Patients Randomized Controlled Trial.
    Crit Care Med. 2017;45:766-773.
    PubMed     Abstract available


  364. DREWRY AM, Ablordeppey EA, Murray ET, Stoll CRT, et al
    Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis.
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    April 2017
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    Sepsis-Associated 30-Day Risk-Standardized Readmissions: Analysis of a Nationwide Medicare Sample.
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    Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis.
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    MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis.
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  368. EMRATH ET, Fortenberry JD, Travers C, McCracken CE, et al
    Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis.
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    Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery.
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    Population-Based Epidemiology of Sepsis in a Subdistrict of Beijing.
    Crit Care Med. 2017 Apr 18. doi: 10.1097/CCM.0000000000002414.
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  371. PINTO BB, Dyson A, Umbrello M, Carre JE, et al
    Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand.
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    PubMed     Abstract available


  372. SCICLUNA BP, van der Poll T
    Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.
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  373. WALLEY KR
    New Approaches to Modifying Inotropy in Sepsis-Induced Myocardial Dysfunction.
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  374. SIMPSON SQ
    Surviving Transfer for Sepsis: Size Matters-Or Does It?
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  375. LAUPLAND KB, Niven DJ
    The Normal Abnormal Vital Sign of Sepsis.
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  376. DEUTSCHMAN CS
    Sepsis-3: Of Love and Bliss.
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  377. ALDER MN, Opoka AM, Lahni P, Hildeman DA, et al
    Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.
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    Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis.
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    March 2017
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    Association Between Hospital Case Volume of Sepsis, Adherence to Evidence-Based Processes of Care and Patient Outcomes.
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    Delayed Second Dose Antibiotics for Patients Admitted From the Emergency Department With Sepsis: Prevalence, Risk Factors, and Outcomes.
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    Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis.
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  382. MOSS TJ, Calland JF, Enfield KB, Gomez-Manjarres DC, et al
    New-Onset Atrial Fibrillation in the Critically Ill.
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  383. MCKOWN AC, McGuinn EM, Ware LB, Wang L, et al
    Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis.
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  384. SCHUETZ P, Birkhahn R, Sherwin R, Jones AE, et al
    Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
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  385. FRENCKEN JF, van Vught LA, Peelen LM, Ong DS, et al
    An Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study.
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  386. PEPPER DJ
    Adipose Tissue Measurements in Patients With Sepsis.
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  387. KUHN SO, Meissner K, Rehberg S
    Fluid Resuscitation in Sepsis: "Get the Balance Right".
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  388. MOROWITZ MJ, Di Caro V, Pang D, Cummings J, et al
    Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.
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    Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study.
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    The Changes in Pulse Pressure Variation or Stroke Volume Variation After a "Tidal Volume Challenge" Reliably Predict Fluid Responsiveness During Low Tidal Volume Ventilation.
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    February 2017
  391. HOOGENDIJK AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, et al
    Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-kappaB in Multiple Cell Types.
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    Delays From First Medical Contact to Antibiotic Administration for Sepsis.
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  393. WHILES BB, Deis AS, Simpson SQ
    Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients.
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  394. BRENT AJ
    Meta-Analysis of Time to Antimicrobial Therapy in Sepsis: Confounding as Well as Bias.
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  395. BRIASSOULIS G, Ilia S
    Vitamin D Deficiency in Sepsis: "Body Humors" Imbalance or Sepsis "Epiphenomenon"?
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  396. BHARDWAJ A, Mikkelsen ME
    Sepsis Quality Improvement Initiatives: Prepare for the Marathon, Not the Sprint.
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  397. ALVERDY JC, Krezalek MA
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    January 2017
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    December 2016
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    1500: STEROID USE FOR REFRACTORY HYPOTENSION IN CONGENITAL DIAPHRAGMATIC HERNIA INCREASES SEPSIS RISK.
    Crit Care Med. 2016;44.
    PubMed    


  424. JUNE A, Bhutta A, Holloway A, Bagdure D, et al
    1493: OUTCOMES OF PATIENTS WITH SEPSIS RELATED TO STAPHALOCOCCUS AUREUS MANAGED WITH ECMO.
    Crit Care Med. 2016;44.
    PubMed    


  425. KYO M, Ohshimo S, Kida Y, Shime N, et al
    1492: THE VALIDATION OF QSOFA CRITERIA FOR SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  426. SAITO N, Kawasaki A, Akizuki N, Namiki M, et al
    1491: ANTITHROMBIN III DEFICIENCY RELATES TO MORTALITY IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  427. BLAU S, Spector R
    1487: SEPSIS CARE IN NEW YORK STATE: SERVING TWO MASTERS.
    Crit Care Med. 2016;44.
    PubMed    


  428. DICK-PEREZ R, Mohr N, Harland K, Ahmed A, et al
    1479: ED CHARGES PREDICT SEVERITY OF ILLNESS AND MORTALITY IN PATIENTS WITH SEVERE SEPSIS/SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  429. EL QADDOUMI H, Roy A, Davis J, Katsikeris F, et al
    1478: PRESENTATION AND COURSE OF PRENATAL SEPSIS IN AN ACADEMIC MEDICAL CENTER.
    Crit Care Med. 2016;44.
    PubMed    


  430. GRAHAM J, Krall B, Presente A, Saucier J, et al
    1477: SOFA SCORES IN PATIENTS TRIGGERING AN EMR-BASED SEPSIS ALERT.
    Crit Care Med. 2016;44.
    PubMed    


  431. NAZER L, Abusara A, Hawari F
    1476: ASSESSING THE 3RD INTERNATIONAL CONSENSUS DEFINITION FOR SEPTIC SHOCK (SEPSIS-3) IN CANCER PATIENTS.
    Crit Care Med. 2016;44.
    PubMed    


  432. DELUCA P, Ali S, Fryckberg A, Vyas N, et al
    1475: ASSESSMENT OF NONCOMPLIANCE WITH BUNDLE THERAPY FOR THE TREATMENT OF SEPSIS ON THE INPATIENT FLOOR.
    Crit Care Med. 2016;44.
    PubMed    


  433. HARTKOPP B, Fletcher S, Ekengren F, Berg G, et al
    1473: TERTIARY HOSPITAL SEPSIS CHAMPION: EDUCATION REVEALS NEEDS AND INCREASES TRANSFERS.
    Crit Care Med. 2016;44.
    PubMed    


  434. JIM F, Li J, Peng Z
    1472: ACTIVATION OF THE CHOLINERGIC ANTIINFLAMMATORY PATHWAY IMPROVES SEPSIS-INDUCED HYPERGLYCEMIA.
    Crit Care Med. 2016;44.
    PubMed    


  435. JAIMES F, Castano P, Plaza M, Molina F, et al
    1470: ANTIBIOTICS PRESCRIPTION IS NOT ASSOCIATED WITH PROGNOSIS IN SEPSIS: A PROSPECTIVE COHORT STUDY.
    Crit Care Med. 2016;44.
    PubMed    


  436. LIMA K, Caynak R, Lara F, Tran N, et al
    1469: LACTATE MONITORING FOR SEVERE SEPSIS AND SEPTIC SHOCK: ARE ALL LACTATE MEASUREMENTS THE SAME?
    Crit Care Med. 2016;44.
    PubMed    


  437. WEISS S, Balamuth F, Fitzgerald J, Hensley J, et al
    1468: EPIDEMIOLOGY OF DEATH FOLLOWING PEDIATRIC SEPSIS: WHEN, WHY, AND HOW SEPTIC KIDS DIE.
    Crit Care Med. 2016;44.
    PubMed    


  438. FRENCKEN J, Donker D, Horn J, Van Der Poll T, et al
    1462: MYOCARDIAL INJURY DURING SEPSIS: INCIDENCE AND ASSOCIATION WITH MORTALITY.
    Crit Care Med. 2016;44.
    PubMed    


  439. BREUER R, Hassinger A
    1461: THE PEDIATRIC PROVIDER EXPERIENCE WITH SEPSIS AND SEPTIC SHOCK (PRESS) STUDY.
    Crit Care Med. 2016;44.
    PubMed    


  440. ZILBERBERG M, Shorr A, Micek S, Williams M, et al
    1460: EPIDEMIOLOGY AND OUTCOMES OF SEPSIS-ASSOCIATED COAGULOPATHY IN SEVERE SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  441. TAKAUJI S, Hayakawa M, Ono K, Fujita S, et al
    1459: VENOARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATION FOR SEVERE SEPSIS AND SEPTIC SHOCK IN 3,195 ADULTS.
    Crit Care Med. 2016;44.
    PubMed    


  442. NOURIEL J, Millis S, Ottolini J, Wilburn J, et al
    1457: THE RELATIONSHIP BETWEEN BLOOD PRESSURE VARIABILITY AND LACTATE IN EARLY SEPSIS RESUSCITATION.
    Crit Care Med. 2016;44.
    PubMed    


  443. GUIRGIS F, Sterling S, Smotherman C, Moore F, et al
    1456: A COMPARISON OF SOFA USING SPO2/FIO2 RATIO TO SOFA, SIRS, AND QSOFA FOR SEPSIS MORTALITY.
    Crit Care Med. 2016;44.
    PubMed    


  444. YUNE H, Kim K, Jo YH, Kim J, et al
    1453: INFUSION OF METHYLENE BLUE IN SEVERE SEPSIS AND SEPTIC SHOCK: A RANDOMIZED CONTROLLED TRIAL.
    Crit Care Med. 2016;44.
    PubMed    


  445. JAIMES F, Londono J, Nino C, Valencia M, et al
    1452: NO IMPROVEMENT WITH EGDT OR ANTIBIOTICS IN PATIENTS WITH SEPSIS: AN INSTRUMENTAL VARIABLE ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  446. HARTOG C, Matt B, Kortgen A, Konig C, et al
    1446: WHAT MATTERS MOST TO SURVIVORS OF SEPSIS? DEVELOPMENT OF PATIENT-REPORTED QUALITY-OF-LIFE DOMAINS.
    Crit Care Med. 2016;44.
    PubMed    


  447. SAKHUJA A, Kumar G, Vallabhajosyula S, Kashyap R, et al
    1445: WHO CAN BE CALLED "ELDERLY" FOR SEVERE SEPSIS MORTALITY?
    Crit Care Med. 2016;44.
    PubMed    


  448. LEVY E, Zinter M, Madden K, Randolph A, et al
    1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  449. HANDY B, Jones P, Ostlund R Jr, Schuetz P, et al
    1440: VALIDATION OF THE ELECSYS BRAHMS PROCALCITONIN ASSAY IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  450. MILZMAN D, Paik M, Shuster K, Floyd R, et al
    1438: EARLY DETERMINATION OF OUTCOMES FOR SIRS VS QSOFA IN ED SEPSIS PATIENTS.
    Crit Care Med. 2016;44.
    PubMed    


  451. WALKER J, Peters M, Nadel S, Pathan N, et al
    1436: THE ABILITY OF SEPSIS CRITERIA TO PREDICT SERIOUS BACTERIAL INFECTION IN CRITICALLY ILL CHILDREN.
    Crit Care Med. 2016;44.
    PubMed    


  452. MORESCO B, Root K, Cuellar C, Harkins L, et al
    1435: EVALUATION OF EARLY MANAGEMENT OF SEPSIS AND COMPLIANCE WITH SEPSIS GUIDELINES.
    Crit Care Med. 2016;44.
    PubMed    


  453. WISKAR K, Boyd J, Rush B
    1434: ASSOCIATION BETWEEN HOSPITAL CHARACTERISTICS AND MORTALITY IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  454. TAYLOR S, Gandy T, Karvestski C, Templin M, et al
    1428: INCIDENCE, PREDICTORS, AND ALTERNATE DIAGNOSES OF PATIENTS WITH FALSE-POSITIVE SEVERE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  455. FERREIRA J, Adams C, Tucker C, Allen B, et al
    1427: EFFICACY OF NON-WEIGHT-BASED VASOPRESSOR DOSING IN CRITICALLY ILL PATIENTS WITH SEVERE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  456. LEISMAN D, D'Amore J, Gribben J, Ward M, et al
    1426: BUNDLE COMPLIANCE EFFECT GREATER IN HEMODYNAMICALLY STABLE SEPSIS PATIENTS WITH INTERMEDIATE LACTATE.
    Crit Care Med. 2016;44.
    PubMed    


  457. SPECTOR R, Blau S
    1425: SEPSIS MANAGEMENT: THE EFFECT OF PROTOCOL INITIATION ON PATIENT OUTCOME.
    Crit Care Med. 2016;44.
    PubMed    


  458. PARK JR, Kim Y, Park T, Oh WY, et al
    1423: MICROCIRCULATORY ALTERATIONS IN HEMORRHAGIC SHOCK AND SEPSIS WITH OPTICAL COHERENCE TOMOGRAPHY.
    Crit Care Med. 2016;44.
    PubMed    


  459. PEARSON D, Benson A, Blanset J, Lovett K, et al
    1422: COMMON REASONS CORE MEASURES ARE NOT MET IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  460. PELTAN I, Mitchell K, Rudd K, Mann B, et al
    1421: PREHOSPITAL LEVEL OF CARE, PREHOSPITAL IV ACCESS, AND TIMING OF ANTIBIOTICS IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  461. IBARRA F, Rowden A, Dzintars K, Lindsley J, et al
    1418: UTILITY OF A SEVERE SEPSIS ORDER SET IN A MEDICAL INTENSIVE CARE UNIT.
    Crit Care Med. 2016;44.
    PubMed    


  462. WOZNIAK J, Dargin J
    1416: THE EFFECT OF PROVIDING CLINICAL PERFORMANCE FEEDBACK ON COMPLIANCE WITH SEPSIS TREATMENT BUNDLES.
    Crit Care Med. 2016;44.
    PubMed    


  463. WOZNIAK J, Dargin J
    1415: THE EFFECT OF PROVIDING CLINICAL PERFORMANCE FEEDBACK ON COMPLIANCE WITH SEPSIS TREATMENT BUNDLES.
    Crit Care Med. 2016;44.
    PubMed    


  464. HUANG C, Daniels R, Lembo A, Heymann T, et al
    1413: MENTAL, PHYSIOLOGIC, AND FUNCTIONAL DISABILITIES IN POST-SEPSIS SYNDROME: AN INTERNATIONAL SURVEY.
    Crit Care Med. 2016;44.
    PubMed    


  465. NGUYEN T, Marini J, Lam F, Cohen D, et al
    1411: PORCINE MODEL OF STAPHYLOCOCCUS AUREUS SEPSIS-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION.
    Crit Care Med. 2016;44.
    PubMed    


  466. STEGER A, Pedersen A, Shears E, Hurst L, et al
    1409: A NURSE-LED APPROACH TO IMPROVE EARLY SEPSIS CARE IN THE EMERGENCY DEPARTMENT.
    Crit Care Med. 2016;44.
    PubMed    


  467. SHAH T, Rech M, Sterk E
    1406: IMPACT OF THE EMERGENCY DEPARTMENT SEPSIS SCREENING TOOL ON OUTCOMES IN PATIENTS WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  468. SAKHUJA A, Kumar G, Vallabhajosyula S, Kashani K, et al
    1405: SEASONAL VARIATIONS IN SEVERE SEPSIS HOSPITALIZATIONS.
    Crit Care Med. 2016;44.
    PubMed    


  469. TAYLOR S, Roohollahi A, Karvetski C, Templin M, et al
    1403: DOES CIRRHOSIS AFFECT THE PROGNOSTIC UTILITY OF LACTATE FOR SEVERE SEPSIS?
    Crit Care Med. 2016;44.
    PubMed    


  470. ATEELI H, Jaffer F, Goel K, Low SW, et al
    1402: CURB-65 SCORE CORRELATES WITH ICU ADMISSION AND IN-HOSPITAL MORTALITY IN PATIENTS WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  471. CUSTER J, Bhutta A, Bagdure D, Holloway A, et al
    1399: OUTCOMES OF PEDIATRIC PATIENTS WITH SEPSIS MANAGED ON EXTRACORPOREAL MEMBRANE OXYGENATION.
    Crit Care Med. 2016;44.
    PubMed    


  472. HOSHINO K, Kawano Y, Maruyama J, Mizunuma M, et al
    1398: PLASMINOGEN ACTIVATOR INHIBITOR-1 IS THE MOST PREDICTIVE MARKER OF MORTALITY IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  473. HUANG C, Daniels R, Lembo A, Heymann T, et al
    1397: SEPSIS SURVIVORS' SATISFACTION WITH SUPPORT SERVICES DURING AND AFTER THEIR HOSPITALIZATION.
    Crit Care Med. 2016;44.
    PubMed    


  474. LEISMAN D, Huang V, Zhou Q, Gribben J, et al
    1396: DELAYED 2ND-DOSE ANTIBIOTICS FOR ED SEPSIS PATIENTS: PREVALENCE, RISK FACTORS, & ASSOCIATED OUTCOMES.
    Crit Care Med. 2016;44.
    PubMed    


  475. TANNEHILL D, O'Brien J, Kasal J, Subramanian S, et al
    1395: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS AND SEPTIC SHOCK PATIENTS.
    Crit Care Med. 2016;44.
    PubMed    


  476. MCHUGH W, McDonough K, Carlton E, Kidwell K, et al
    1394: PERSONALIZED IMMUNOMODULATION IN HIGH-RISK SEPSIS PATIENTS IN A PEDIATRIC CRITICAL CARE UNIT.
    Crit Care Med. 2016;44.
    PubMed    


  477. MAHAPATRA S, Ying L, Steinman L, Cornfield D, et al
    1393: AN AMYLOIDOGENIC HEXAPEPTIDE, AMYLIN, ATTENUATES INFLAMMATION AND ACUTE LUNG INJURY IN MURINE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  478. FUKUDA S, Randolph A, Ihara K, Cox R, et al
    1390: PEROXYNITRITE DECOMPOSITION CATALYST REDUCES NOREPINEPHRINE REQUIREMENT DURING SEPSIS IN OVINE MODEL.
    Crit Care Med. 2016;44.
    PubMed    


  479. MOORE C, Ainsworth J, Wang Y, Barnes L, et al
    1389: OPTIMIZED PREDICTIVE MONITORING OF NON-INTENSIVE CARE UNIT PATIENTS AT RISK FOR SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  480. RUSH B, Wiskar K, Boyd J
    1388: ASSOCIATION OF WEEKEND ADMISSION WITH SEPSIS MORTALITY IN THE UNITED STATES.
    Crit Care Med. 2016;44.
    PubMed    


  481. KWAK S
    1387: FLECAINIDE ATTENUATES SEPSIS-INDUCED ACUTE LUNG INJURY BY CONTROLLING INFLAMMATORY RESPONSE.
    Crit Care Med. 2016;44.
    PubMed    


  482. TRAN N, Lima K, Caynak R, Scobino C, et al
    1385: EVALUATION OF PROCALCITONIN-DIRECTED TREATMENT OF SEPSIS IN PEDIATRIC INTENSIVE CARE PATIENTS.
    Crit Care Med. 2016;44.
    PubMed    


  483. STILL M, Carpenter D, Holder C, Murphy D, et al
    1384: SUCCESS WITH IMPLEMENTATION OF A SYSTEM-BASED SEPSIS MANAGEMENT PROGRAM.
    Crit Care Med. 2016;44.
    PubMed    


  484. RINATO K, Pretto-Sparkuhl A, Mauch H, Viti L, et al
    1383: IMPACT OF AN ENHANCED "CODE SEPSIS" PROGRAM ON MORTALITY OF ED PATIENTS PRESENTING WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  485. AAKRE C, Kitson J, Herasevich V
    1380: TIME-MOTION ANALYSIS AND ECONOMIC IMPACT OF SOFA SCORE INTEGRATION INTO THE NEW SEPSIS-3 DEFINITION.
    Crit Care Med. 2016;44.
    PubMed    


  486. LEWIS A, Yuan D, Zhang X, Collage R, et al
    1379: BLUE LIGHT THERAPY MODULATES THE SYSTEMIC RESPONSE TO SEPSIS IN MICE AND HUMANS.
    Crit Care Med. 2016;44.
    PubMed    


  487. SATO R, Kuriyama A, Takada T, Nasu M, et al
    1377: PREVALENCE AND RISK FACTORS OF SEPSIS-INDUCED CARDIOMYOPATHY: A RETROSPECTIVE COHORT STUDY.
    Crit Care Med. 2016;44.
    PubMed    


  488. GELVEZ J, Olarte JL, Williams L, Darnell C, et al
    1376: THE EFFECT OF EMERGENCY ROOM FLUID RESUSCITATION ON PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  489. HUDCOVA J, Poutsiaka D, Khan M, Waqas A, et al
    1374: UTILITY OF PRESEPSIN IN DISTINGUISHING SEPSIS FROM SYSTEMIC INFLAMMATORY RESPONSE SYNDROME.
    Crit Care Med. 2016;44.
    PubMed    


  490. LIMA L, McCracken C, Fortenberry J, Hebbar K, et al
    1373: UTILITY OF PLASMA EXCHANGE IN PEDIATRIC SEVERE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  491. MIKACENIC C, Price B, Harju-Baker S, Katz R, et al
    1372: DEVELOPMENT OF A ROBUST BIOMARKER PREDICTIVE MODEL FOR DEATH IN ICU PATIENTS WITH SIRS AND SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  492. SCOTT H, Brou L, Deakyne S, Bajaj L, et al
    1371: USING LACTATE AND BLOOD PRESSURE TO CLASSIFY SHOCK IN PEDIATRIC SEPSIS: AN EHR-BASED APPROACH.
    Crit Care Med. 2016;44.
    PubMed    


  493. TAYLOR B, Gunn E, Templin M, Karvestski C, et al
    1370: VOLUME ADMINISTRATION AND OUTCOMES IN OBESE PATIENTS WITH SEPSIS IN THE ERA OF PROTOCOLIZED CARE.
    Crit Care Med. 2016;44.
    PubMed    


  494. LI X, Guo L, Yuan Y, Zhan CG, et al
    1368: SYNTHETIC HDL AS AN EFFECTIVE THERAPY FOR SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  495. CHUNG KS, Kim CY, Lee SH, Kim SK, et al
    1366: CLINICAL IMPLICATIONS OF THE PLASMA EPHA2 RECEPTOR LEVEL IN PATIENTS WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  496. TANNEHILL D, Sharpe B, Miller M, Saifo A, et al
    1365: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS PATIENTS TREATED OUTSIDE THE ICU.
    Crit Care Med. 2016;44.
    PubMed    


  497. GASPERINO J, Gabriel-Jocson E, Perez E, Levy R, et al
    1364: COMPARISON OF THE QSOFA SCORE AND SIRS CRITERIA IN PATIENTS WITH KNOWN OR SUSPECTED SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  498. ZHAI X, Jiang L, Yang Z, Yu T, et al
    1363: EFFECT OF ULINASTATIN ON MICROCIRCULATION DURING SEPSIS IN A RAT CECAL LIGATION AND PUNCTURE MODEL.
    Crit Care Med. 2016;44.
    PubMed    


  499. VALLABHAJOSYULA S, Jentzer J, Geske J, Kashani K, et al
    1362: LONG-TERM NEW-ONSET HEART FAILURE IN PATIENTS WITH MYOCARDIAL DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  500. WALSH M, Hobbs B, Giancarelli A, Bhullar I, et al
    1357: THE EFFECT OF OBESITY ON MORTALITY IN TRAUMA PATIENTS WITH SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  501. TAYLOR B, Alexander M, Karvestski C, Templin M, et al
    1354: AN AGGRESSIVE SEPSIS IDENTIFICATION INITIATIVE INCREASES FALSE-POSITIVE DIAGNOSES.
    Crit Care Med. 2016;44.
    PubMed    


  502. LANTRY J, April M
    1353: SEPSIS CLINICAL CRITERIA IN ED PATIENTS ADMITTED TO AN ICU: AN EXTERNAL VALIDATION STUDY OF QSOFA.
    Crit Care Med. 2016;44.
    PubMed    


  503. HAILESELASSIE B, Su E, Nino D, Liu H, et al
    1352: IMPACT OF MITOCHONDRIAL ROS SCAVENGERS ON CARDIAC MECHANICS IN A MURINE MODEL OF SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  504. KAWANO Y, Hoshino K, Irie Y, Izutani Y, et al
    1347: USEFULNESS OF SEPSIS BIOMARKERS ACCORDING TO THE NEW DEFINITIONS OF SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  505. REILLY J, Shashaty M, Anderson B, Palakshappa J, et al
    1344: PLASMA RIP3, A REGULATOR OF NECROPTOSIS, IS ASSOCIATED WITH MORTALITY & ORGAN DYSFUNCTION IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  506. WEST A, Mangubat PM, Giles K, Guynn A, et al
    1343: ANALYZING ACCURACY AND EARLY DETERMINANTS OF SEVERE SEPSIS USING REAL-TIME EMR INTEGRATED ALGORITHM.
    Crit Care Med. 2016;44.
    PubMed    


  507. TYLER P, Celi LA, Rush B
    1342: INTERHOSPITAL TRANSFER OF PATIENTS WITH SEPSIS ACROSS THE UNITED STATES.
    Crit Care Med. 2016;44.
    PubMed    


  508. MARIK P, Bittner E, Hansell D, Sahatjian J, et al
    1341: FLUID ADMINISTRATION IN SEPSIS/SEPTIC SHOCK, PATTERNS AND OUTCOMES: LARGE NATIONAL DATABASE ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  509. AMES S, Davis B, Carcillo J, Angus D, et al
    1338: HOSPITAL-LEVEL VARIATION IN RISK-ADJUSTED MORTALITY FOR PEDIATRIC SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  510. MAYR F, Balakumar V, Talisa V, Fine M, et al
    1336: UNDERSTANDING THE BURDEN OF UNPLANNED SEPSIS READMISSIONS.
    Crit Care Med. 2016;44.
    PubMed    


  511. SALOMON J, Serrao K, Guardiola J, Bonura A, et al
    1335: EARLY DETECTION OF PEDIATRIC SEPSIS USING AN ELECTRONIC MEDICAL RECORD-BASED SCREENING TOOL.
    Crit Care Med. 2016;44.
    PubMed    


  512. LU M, Chen E
    1334: MMF PROTECTS AGAINST LIVER INJURY DURING SEPSIS VIA REGULATION OF MAPK AND NF-KappaB PATHWAYS.
    Crit Care Med. 2016;44.
    PubMed    


  513. PROUT A, Talisa V, Mayr F, Yende S, et al
    1333: PEDIATRIC SEPSIS AND SEPTIC SHOCK: RISK FACTORS AND COMORBID CONDITIONS.
    Crit Care Med. 2016;44.
    PubMed    


  514. KASAL J, Stoll B, Katyal A, Tannehill D, et al
    1331: ASSESSMENT OF QSOFA AND OTHER CRITERIA IN SEPSIS WITH NORMAL BLOOD PRESSURE AND INTERMEDIATE LACTATE.
    Crit Care Med. 2016;44.
    PubMed    


  515. ZHANG LA, Parker R, Banerjee I, Clermont G, et al
    1330: SEPSIS ENDOTYPES AND THEIR PHYSIOLOGIC CHARACTERIZATION USING VITAL SIGNS.
    Crit Care Med. 2016;44.
    PubMed    


  516. FAY K, Klingensmith N, Lyons J, Ramonell K, et al
    1329: CD43 SIGNALING CONTROLS SURVIVAL, TH2 SKEWING, AND MEMORY T CELL APOPTOSIS DURING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  517. KILLIEN E, Farris R, Watson R, Flanagin M, et al
    1328: DETERIORATION IN HEALTH-RELATED QUALITY OF LIFE IS COMMON AMONG CHILDREN SURVIVING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  518. MENG X, Zhai Y, Ao L, Hui H, et al
    1326: AGING ELEVATES MYOCARDIAL TLR2 LEVELS TO AUGMENT CARDIAC DYSFUNCTION AND MORTALITY DURING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  519. SUZUKI K, Okada H, Takada C, Oda K, et al
    1325: HYDROCORTISONE THERAPY WITH CAR PEPTIDE PROTECTS THE INJURED ENDOTHELIAL GLYCOCALYX IN SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  520. FOUNTAIN S, Perry J 3rd, Stoffer B, Raschke R, et al
    1278: DESIGN OF AN ELECTRONIC MEDICAL RECORD-BASED ALERT SYSTEM TO DETECT THE ONSET OF SEVERE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  521. PENOYER D, Snyder J, Inderwiesen P, Geddie P, et al
    1229: SEPSIS CORE MEASURES AND BLOOD CULTURE DOCUMENTATION: TIMING IS EVERYTHING!
    Crit Care Med. 2016;44.
    PubMed    


  522. BORGES N, Bavare A, Cruz A, Patel B, et al
    1204: RAPID RESPONSE TO PEDIATRIC SEPSIS IN A TERTIARY CHILDREN'S HOSPITAL: BATTLING COMPLEXITY.
    Crit Care Med. 2016;44.
    PubMed    


  523. BALDAWI M, Al-Jubouri M, Watson J, Kathrin Jaehne A, et al
    1104: THE POTENTIAL FINANCIAL CONSEQUENCE OF THE NEW SEPSIS-3 SEPSIS DEFINITIONS.
    Crit Care Med. 2016;44.
    PubMed    


  524. BLAHA K, Diaz F, Quilodran J, Medina T, et al
    934: SAFETY AND EFFICACY OF A PREVENTIVE STRATEGY FOR FLUID OVERLOAD IN CHILDREN WITH SEPSIS AND PARDS.
    Crit Care Med. 2016;44.
    PubMed    


  525. PANG D, Wu Y, Cummings J, Panigrahy A, et al
    721: MICROGLIAL ACTIVATION CORRELATES WITH CYTOTOXIC EDEMA IN A MURINE MODEL OF SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  526. SADAKA F, Korobey M, Dumm A, Wegener G, et al
    692: PRACTICE PATTERNS FOR ANTIBIOTIC DE-ESCALATION IN MRSA CULTURE-NEGATIVE SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  527. ZILBERBERG M, Nathanson B, Sulham K, Fan W, et al
    645: HOSPITAL RESOURCE USE ASSOCIATED WITH TREATMENT OF ACINETOBACTER BAUMANNII PNEUMONIA AND SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  528. ALCAMO A, Alessi L, Noona Vehovic S, Pang D, et al
    626: MULTIDRUG-RESISTANT ORGANISM SEPSIS IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS: A BURGEONING PROBLEM.
    Crit Care Med. 2016;44.
    PubMed    


  529. GUL F, Kemal Arslantas M, Bilgili B, Besir A, et al
    482: SERUM VITAMIN D LEVEL VARIATION IN SIRS, SEPSIS, AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  530. HASSINGER A, Breuer R
    434: SEPSIS DRILLS: A MULTIDISCIPLINARY SEPSIS EDUCATIONAL PROGRAM IN A PEDIATRIC HOSPITAL.
    Crit Care Med. 2016;44.
    PubMed    


  531. VILLAR J, Lighthall G
    333: SERUM LACTATE LEVEL PREDICTS 3-DAY, 30-DAY, AND 1-YEAR MORTALITY IN PATIENTS WITH AND WITHOUT SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  532. MORGAN R, Sutton R, Kilbaugh T, Lautz A, et al
    287: PULMONARY VASODILATOR THERAPY IN A SWINE MODEL OF PEDIATRIC SEPSIS-ASSOCIATED CARDIAC ARREST.
    Crit Care Med. 2016;44.
    PubMed    


  533. VALLABHAJOSYULA S, Kashyap R, Geske J, Sakhuja A, et al
    185: DOPPLER-DEFINED ACUTE PULMONARY HYPERTENSION IN SEPSIS AND SEPTIC SHOCK.
    Crit Care Med. 2016;44.
    PubMed    


  534. HIRATA JI, Ohya M
    107: OXIDANT/ANTIOXIDANT TREATMENT INFLUENCES PULMONARY DNA VIA MTH1 MODIFICATIONS IN SEPSIS-INDUCED ALI.
    Crit Care Med. 2016;44.
    PubMed    


  535. VALLABHAJOSYULA S, Kashyap R, Geske J, Kumar M, et al
    28: RIGHT VENTRICULAR DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK: AN EIGHT-YEAR ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  536. VALLABHAJOSYULA S, Jentzer J, Geske J, Sakhuja A, et al
    23: CARDIORENAL SYNDROME IN SEPSIS AND SEPTIC SHOCK: THE MAYO CLINIC EXPERIENCE.
    Crit Care Med. 2016;44.
    PubMed    


  537. KATSIOS C, Doumouras A, Shaefi S, Novack V, et al
    22: CONSERVATIVE FLUID STRATEGIES DECREASE MORTALITY IN SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.
    Crit Care Med. 2016;44.
    PubMed    


  538. HIRANO Y, Aziz M, Weng-Lang Y, Ochani M, et al
    21: THE ROLE OF JUNCTIONAL ADHESION MOLECULE C IN THE AGING PHENOTYPE OF NEUTROPHILS DURING SEPSIS.
    Crit Care Med. 2016;44.
    PubMed    


  539. JOHNSON A, Celi LA, Raffa J, Pollard T, et al
    18: EXTERNAL VALIDATION OF THE SEPSIS-3 GUIDELINES.
    Crit Care Med. 2016;44.
    PubMed    


  540. ENKHBAATAR P
    Cellular Therapy for Sepsis: A New Hope?
    Crit Care Med. 2016;44:2296-2298.
    PubMed    


  541. KEMPKER JA, Martin GS
    Does Sepsis Case Mix Heterogeneity Prevent Outcome Comparisons?
    Crit Care Med. 2016;44:2288-2289.
    PubMed    


  542. TOWNSEND SR
    Collaborating for Success in Sepsis Quality Improvement.
    Crit Care Med. 2016;44:2275-2277.
    PubMed    


    November 2016
  543. ZHANG Z, Li Q
    Identifying Sepsis in Clinical Database With Sepsis-3 Definition.
    Crit Care Med. 2016;44:e1145-e1146.
    PubMed    


  544. ZIMMERMAN JJ, Davis R
    Imprecise (Sepsis) Medicine Can Become Precise.
    Crit Care Med. 2016;44:e1143-e1144.
    PubMed    


  545. SAVEL RH, Simon RJ, Kupfer Y
    Unraveling the Mysterious Relationship Between Obesity and Outcomes in Patients With Sepsis.
    Crit Care Med. 2016;44:2104-2105.
    PubMed    


  546. COHEN M, Falcone P, Kusnezov D, Paragas J, et al
    Sepsis and Presidential Initiatives.
    Crit Care Med. 2016;44:1963-1965.
    PubMed    


    October 2016
  547. JAEHNE AK, Rivers EP
    Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly.
    Crit Care Med. 2016.
    PubMed    


  548. YOUKEE D, Hulme W, Roberts T, Daniels R, et al
    Time Matters: Antibiotic Timing in Sepsis and Septic Shock.
    Crit Care Med. 2016;44:e1016-e1017.
    PubMed    


  549. SHIRAKURA Y, Kuriyama A
    Timing of Antibiotic Administration in Sepsis and Septic Shock: The Impact That a Meta-Analysis Does Not Depict.
    Crit Care Med. 2016;44:e1004.
    PubMed    


  550. MARRARO GA, Genovese U
    The Treatment of Severe Sepsis in the Pediatric Age: Long-Awaited Prospects and New Challenges Are Looming.
    Crit Care Med. 2016;44:1960-1962.
    PubMed    


    September 2016
  551. PREAU S, Bortolotti P, Colling D, Dewavrin F, et al
    Diagnostic Accuracy of the Inferior Vena Cava Collapsibility to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis and Acute Circulatory Failure.
    Crit Care Med. 2016.
    PubMed     Abstract available


  552. SWEENEY TE, Khatri P
    Benchmarking Sepsis Gene Expression Diagnostics Using Public Data.
    Crit Care Med. 2016.
    PubMed     Abstract available


  553. SCHEER CS, Fuchs C, Kuhn SO, Vollmer M, et al
    Quality Improvement Initiative for Severe Sepsis and Septic Shock Reduces 90-Day Mortality: A 7.5-Year Observational Study.
    Crit Care Med. 2016.
    PubMed     Abstract available


  554. ZIMMERMAN JJ, Sullivan E, Yager TD, Cheng C, et al
    Diagnostic Accuracy of a Host Gene Expression Signature That Discriminates Clinical Severe Sepsis Syndrome and Infection-Negative Systemic Inflammation Among Critically Ill Children.
    Crit Care Med. 2016.
    PubMed     Abstract available


  555. SEPULVEDA M, Gonano LA, Viotti M, Morell M, et al
    Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
    Crit Care Med. 2016.
    PubMed     Abstract available


  556. MIRA JC, Gentile LF, Mathias BJ, Efron PA, et al
    Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
    Crit Care Med. 2016.
    PubMed     Abstract available


  557. DALLI J, Colas RA, Quintana C, Barragan-Bradford D, et al
    Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.
    Crit Care Med. 2016.
    PubMed     Abstract available


  558. MELLA JR, Chiswick E, Stepien D, Moitra R, et al
    Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.
    Crit Care Med. 2016.
    PubMed     Abstract available


  559. PAREKH D, Patel JM, Scott A, Lax S, et al
    Vitamin D Deficiency in Human and Murine Sepsis.
    Crit Care Med. 2016.
    PubMed     Abstract available


  560. AARVOLD AB, Ryan HM, Magee LA, von Dadelszen P, et al
    Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients.
    Crit Care Med. 2016.
    PubMed     Abstract available


  561. OAMI T, Watanabe E, Hatano M, Sunahara S, et al
    Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model.
    Crit Care Med. 2016.
    PubMed     Abstract available


  562. BEESLEY SJ, Wilson EL, Lanspa MJ, Grissom CK, et al
    Relative Bradycardia in Patients With Septic Shock Requiring Vasopressor Therapy.
    Crit Care Med. 2016.
    PubMed     Abstract available


  563. MOHR NM, Harland KK, Shane DM, Ahmed A, et al
    Rural Patients With Severe Sepsis or Septic Shock who Bypass Rural Hospitals Have Increased Mortality: An Instrumental Variables Approach.
    Crit Care Med. 2016.
    PubMed     Abstract available


  564. MARTINEZ ML, Ferrer R, Torrents E, Guillamat-Prats R, et al
    Impact of Source Control in Patients With Severe Sepsis and Septic Shock.
    Crit Care Med. 2016.
    PubMed     Abstract available


    April 2016
  565. RHEE C
    Cytokine Imbalance Predicts Poor Outcomes in Staphylococcus aureus Bacteremia--But What Can We Do About It?
    Crit Care Med. 2016;44:846-7.
    PubMed    


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