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Articles published in Crit Care Med

Retrieve available abstracts of 153 articles:
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Single Articles


    October 2022
  1. HONORE PM, Redant S, Djimafo P, Blackman S, et al
    Potential Confounders in Study Concluding Higher Lactate at Vasopressin Initiation Is Associated With Higher Mortality in Septic Shock.
    Crit Care Med. 2022;50:e775-e776.
    PubMed    


  2. KLOMPAS M, Goldberg SA
    Turning Back the Clock: Prehospital Antibiotics for Patients With Septic Shock.
    Crit Care Med. 2022;50:1537-1540.
    PubMed    


  3. JOUFFROY R, Gilbert B, Tourtier JP, Bloch-Laine E, et al
    Prehospital Bundle of Care Based on Antibiotic Therapy and Hemodynamic Optimization Is Associated With a 30-Day Mortality Decrease in Patients With Septic Shock.
    Crit Care Med. 2022;50:1440-1448.
    PubMed     Abstract available


    September 2022
  4. FIORINO C, Liu Y, Henao R, Ko ER, et al
    Host Gene Expression to Predict Sepsis Progression.
    Crit Care Med. 2022 Sep 30. pii: 00003246-990000000-00045.
    PubMed     Abstract available


  5. HONORE PM, Redant S, Djimafo P, Preseau T, et al
    Therapeutic Hyperthermia Leads to Improved Sepsis Survival: Beware of Potential Confounders!
    Crit Care Med. 2022;50:e734-e735.
    PubMed    


    August 2022
  6. KULA R
    Therapeutic Hyperthermia Is Associated With Improved Survival in Afebrile Critically Ill Patients With Sepsis: A Pilot Randomized Trial.
    Crit Care Med. 2022;50:e693-e694.
    PubMed    


  7. MENDELSOHN SA, Dellinger RP
    Sepsis Awareness Is Good, Please Do Not Let It Be Misunderstood.
    Crit Care Med. 2022;50:1277-1279.
    PubMed    


    July 2022
  8. NATH SS, Nachimuthu N
    Oversight in Executive Summary of Sepsis Guidelines 2021.
    Crit Care Med. 2022;50:e649.
    PubMed    


    June 2022
  9. FEICHTINGER S, de Man A, Dalia AA, Groose MK, et al
    Sepsis and Resuscitation: The Importance of Time.
    Crit Care Med. 2022;50:e615-e616.
    PubMed    


  10. VEZZA T, Victor VM
    Metformin: An Intriguing Protective Agent in Hospitalized Diabetic Patients With Sepsis.
    Crit Care Med. 2022;50:1018-1020.
    PubMed    


  11. SWEENEY DA, Kalil AC
    From Syphilis to Sepsis: Pilot Studies and the Importance of Staying Grounded.
    Crit Care Med. 2022;50:1015-1018.
    PubMed    


  12. HONORE PM, Redant S, Djimafo P, Preseau T, et al
    Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors!
    Crit Care Med. 2022;50:e611-e612.
    PubMed    


  13. DUGAR S, Khanna AK, Duggal A
    Is Early Vasopressor Safe in Septic Shock?
    Crit Care Med. 2022;50:e599-e600.
    PubMed    


  14. BRUBAKER LS, Saini A, Nguyen TC, Martinez-Vargas M, et al
    Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
    Crit Care Med. 2022;50:e557-e568.
    PubMed     Abstract available


  15. MUKHERJEE R, Tompkins CA, Ostberg NP, Joshi AU, et al
    Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.
    Crit Care Med. 2022;50:e504-e515.
    PubMed     Abstract available


    May 2022
  16. AGARWAL A, Oczkowski S, Sevransky J
    Phase 2 Vitamin C Sepsis Trials: Another Brick in the (Evidence) Wall?
    Crit Care Med. 2022;50:897-899.
    PubMed    


  17. RHEE C, Septimus EJ
    Heterogeneity in Clinical Presentations of Sepsis: Challenges and Implications for "One-Size-Fits-All" Time-to-Antibiotic Measures.
    Crit Care Med. 2022;50:886-889.
    PubMed    


  18. BARBASH IJ
    Moving Forward: Frailty and Adverse Sepsis Outcomes.
    Crit Care Med. 2022;50:880-882.
    PubMed    


  19. XU R, Miao L, Yang C, Zhu B, et al
    Key Role of Gut Microbiota in Neuroinflammation of Septic Patients.
    Crit Care Med. 2022;50:e500-e502.
    PubMed    


  20. WACKER DA, Burton SL, Berger JP, Hegg AJ, et al
    Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy.
    Crit Care Med. 2022;50:e458-e467.
    PubMed     Abstract available


  21. USHER MG, Tourani R, Webber B, Tignanelli CJ, et al
    Patient Heterogeneity and the J-Curve Relationship Between Time-to-Antibiotics and the Outcomes of Patients Admitted With Bacterial Infection.
    Crit Care Med. 2022;50:799-809.
    PubMed     Abstract available


    April 2022
  22. FIEST KM, Krewulak KD, Brundin-Mather R, Leia MP, et al
    Patient, Public, and Healthcare Professional's Sepsis Awareness, Knowledge, and Information Seeking Behaviors: A Scoping Review.
    Crit Care Med. 2022 Apr 29. pii: 00003246-990000000-00008.
    PubMed     Abstract available


  23. DREWRY A, Mohr NM
    Temperature Management in the ICU.
    Crit Care Med. 2022 Apr 15. pii: 00003246-990000000-00005.
    PubMed     Abstract available



  24. Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021: Erratum.
    Crit Care Med. 2022;50:e413-e414.
    PubMed    


  25. MATSUDA W, Yamamoto M
    How Should We Use Frailty Evaluation for Patients With Sepsis in the Clinical Practice?
    Crit Care Med. 2022;50:e399-e400.
    PubMed    


  26. CONWAY MORRIS A
    New Movement in Sepsis Immunotherapeutics-A Role for Prokineticin 2?
    Crit Care Med. 2022;50:714-716.
    PubMed    


  27. RIMAWI RH, Jacob JT
    Sepsis: The Gift That Keeps Giving.
    Crit Care Med. 2022;50:689-691.
    PubMed    


  28. WANG H, He H, Shen F
    Early Vasopressor Initiation Increases Mortality in Patients With Septic Shock: Less Intensive Intervention or More Critically Ill Patients?
    Crit Care Med. 2022;50:e402-e403.
    PubMed    


  29. CHALFIN DB
    Vasopressor Therapy Early, or Vasopressors Later? Still an Important Question in Septic Shock.
    Crit Care Med. 2022;50:717-718.
    PubMed    


  30. YEO HJ, Lee YS, Kim TH, Jang JH, et al
    Vasopressor Initiation Within 1 Hour of Fluid Loading Is Associated With Increased Mortality in Septic Shock Patients: Analysis of National Registry Data.
    Crit Care Med. 2022;50:e351-e360.
    PubMed     Abstract available


  31. SACHA GL, Kiser TH, Wright GC, Vandivier RW, et al
    Association Between Vasopressin Rebranding and Utilization in Patients With Septic Shock.
    Crit Care Med. 2022;50:644-654.
    PubMed     Abstract available


  32. SACHA GL, Lam SW, Wang L, Duggal A, et al
    Association of Catecholamine Dose, Lactate, and Shock Duration at Vasopressin Initiation With Mortality in Patients With Septic Shock.
    Crit Care Med. 2022;50:614-623.
    PubMed     Abstract available


  33. VENET F, Textoris J, Blein S, Rol ML, et al
    Immune Profiling Demonstrates a Common Immune Signature of Delayed Acquired Immunodeficiency in Patients With Various Etiologies of Severe Injury.
    Crit Care Med. 2022;50:565-575.
    PubMed     Abstract available


  34. PETERS VAN TON AM, Meijer-van Leijsen EMC, Bergkamp MI, Bronkhorst EM, et al
    Risk of Dementia and Structural Brain Changes Following Nonneurological Infections During 9-Year Follow-Up.
    Crit Care Med. 2022;50:554-564.
    PubMed     Abstract available


    March 2022
  35. CHATTERJEE AB
    The IMPACT of Transitional Care Management in Sepsis.
    Crit Care Med. 2022;50:525-527.
    PubMed    


  36. GREEN JM, Taylor HA
    Improving Sepsis Care: Is It Research? Promoting Clarity in a Zone of Confusion.
    Crit Care Med. 2022;50:516-519.
    PubMed    


  37. PATEL JJ, Ortiz-Reyes A, Dhaliwal R, Clarke J, et al
    IV Vitamin C in Critically Ill Patients: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2022;50:e304-e312.
    PubMed     Abstract available


  38. BARICHELLO T, Generoso JS, Dominguini D, Corneo E, et al
    Postmortem Evidence of Brain Inflammatory Markers and Injury in Septic Patients: A Systematic Review.
    Crit Care Med. 2022;50:e241-e252.
    PubMed     Abstract available


    February 2022
  39. DURAND M, Hagimont E, Louis H, Asfar P, et al
    The beta1-Adrenergic Receptor Contributes to Sepsis-Induced Immunosuppression Through Modulation of Regulatory T-Cell Inhibitory Function.
    Crit Care Med. 2022 Feb 18. pii: 00003246-900000000-94984.
    PubMed     Abstract available


  40. GOMEZ H, Del Rio-Pertuz G, Priyanka P, Manrique-Caballero CL, et al
    Association of Metformin Use During Hospitalization and Mortality in Critically Ill Adults With Type 2 Diabetes Mellitus and Sepsis.
    Crit Care Med. 2022 Feb 7. pii: 00003246-900000000-95003.
    PubMed     Abstract available


  41. DREWRY AM, Mohr NM, Ablordeppey EA, Dalton CM, et al
    Therapeutic Hyperthermia Is Associated With Improved Survival in Afebrile Critically Ill Patients With Sepsis: A Pilot Randomized Trial.
    Crit Care Med. 2022 Feb 7. pii: 00003246-900000000-95002.
    PubMed     Abstract available


    January 2022
  42. INAGAWA T, Ohshimo S, Shime N
    Concerning the Association Between Delayed Administration of Antibiotics and Mortality in Patients With Suspected Sepsis.
    Crit Care Med. 2022;50:e87-e88.
    PubMed    


  43. PARKER MM
    Sepsis Definitions: I Know It When I See It.
    Crit Care Med. 2022;50:148-150.
    PubMed    


  44. YANG Y, Lu X, Xiao Z
    Insights on Blood Product Transfusions on ICU-Acquired Infections in Septic Shock.
    Crit Care Med. 2022;50:e102.
    PubMed    


    December 2021
  45. HONORE PM, Redant S, Preseau T, Kaefer K, et al
    Procalcitonin as a Mediator in Sepsis: Are We Reinventing the Wheel?
    Crit Care Med. 2021;49:e1255-e1256.
    PubMed    


  46. KIMBALL SL, Levy MM
    Sepsis and the Opioid Crisis: Integrating Treatment for Two Public Health Emergencies.
    Crit Care Med. 2021;49:2151-2153.
    PubMed    


  47. BIBAN P, Marlow N, Te Pas AB, Fanaroff AA, et al
    Advances in Neonatal Critical Care: Pushing at the Boundaries and Connecting to Long-Term Outcomes.
    Crit Care Med. 2021;49:2003-2016.
    PubMed    


    November 2021
  48. RHEE C, Klompas M
    Conducting Sepsis Surveillance by Applying Sepsis-3 Criteria to Electronic Health Record Data: Promises and Potential Pitfalls.
    Crit Care Med. 2021;49:1983-1986.
    PubMed    


  49. EVANS L, Rhodes A, Alhazzani W, Antonelli M, et al
    Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.
    Crit Care Med. 2021;49:1974-1982.
    PubMed    


  50. MARTIN GS, Kane-Gill SL, Nadkarni V, Sorce LR, et al
    The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients.
    Crit Care Med. 2021;49:1849-1850.
    PubMed    


  51. SHAPPELL CN, Klompas M, Ochoa A, Rhee C, et al
    Likelihood of Bacterial Infection in Patients Treated With Broad-Spectrum IV Antibiotics in the Emergency Department.
    Crit Care Med. 2021;49:e1144-e1150.
    PubMed     Abstract available


    October 2021
  52. LEE HY, Lee J, Jung YS, Kwon WY, et al
    Preexisting Clinical Frailty Is Associated With Worse Clinical Outcomes in Patients With Sepsis.
    Crit Care Med. 2021 Oct 6. pii: 00003246-900000000-95052.
    PubMed     Abstract available


  53. MENON K, Schlapbach LJ, Akech S, Argent A, et al
    Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.
    Crit Care Med. 2021 Oct 6. pii: 00003246-900000000-95050.
    PubMed     Abstract available


  54. EVANS L, Rhodes A, Alhazzani W, Antonelli M, et al
    Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
    Crit Care Med. 2021 Oct 4. pii: 00003246-900000000-95059.
    PubMed    


  55. CHOTALIA M, Ali M, Hebballi R, Singh H, et al
    Hyperdynamic Left Ventricular Ejection Fraction in ICU Patients With Sepsis.
    Crit Care Med. 2021 Oct 4. pii: 00003246-900000000-95057.
    PubMed     Abstract available


  56. HAN X, Spicer A, Carey KA, Gilbert ER, et al
    Identifying High-Risk Subphenotypes and Associated Harms From Delayed Antibiotic Orders and Delivery.
    Crit Care Med. 2021;49:1694-1705.
    PubMed     Abstract available


    September 2021
  57. KHOWAJA AR, Willms AJ, Krause C, Carriere S, et al
    The Return on Investment of a Province-Wide Quality Improvement Initiative for Reducing In-Hospital Sepsis Rates and Mortality in British Columbia, Canada.
    Crit Care Med. 2021 Sep 29. pii: 00003246-900000000-95060.
    PubMed     Abstract available


  58. YU X, Chen J, Tang H, Tu Q, et al
    Identifying Prokineticin2 as a Novel Immunomodulatory Factor in Diagnosis and Treatment of Sepsis.
    Crit Care Med. 2021 Sep 27. pii: 00003246-900000000-95065.
    PubMed     Abstract available


  59. FRANK CE, Buchman TG, Simpson SQ, Sciarretta KL, et al
    Sepsis Among Medicare Beneficiaries: 4. Precoronavirus Disease 2019 Update January 2012-February 2020.
    Crit Care Med. 2021 Sep 27. pii: 00003246-900000000-95064.
    PubMed     Abstract available


  60. ASSOULINE B, Faivre A, Verissimo T, Sangla F, et al
    Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.
    Crit Care Med. 2021 Sep 27. pii: 00003246-900000000-95063.
    PubMed     Abstract available


  61. TAYLOR SP, Murphy S, Rios A, McWilliams A, et al
    Effect of a Multicomponent Sepsis Transition and Recovery Program on Mortality and Readmissions After Sepsis: The Improving Morbidity During Post-Acute Care Transitions for Sepsis Randomized Clinical Trial.
    Crit Care Med. 2021 Sep 16. pii: 00003246-900000000-95096.
    PubMed     Abstract available


  62. SATO R, Hasegawa D, Prasitlumkum N, Ueoka M, et al
    Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Crit Care Med. 2021 Sep 8. pii: 00003246-900000000-95105.
    PubMed     Abstract available


  63. YASUHARA S, Alston TA, Martyn JAJ
    Freshly Isolated Mitochondria as Therapeutic Agents in Sepsis: Can They Go Home Again?
    Crit Care Med. 2021;49:1584-1587.
    PubMed    


  64. KANTH SM, Torabi-Parizi P
    Personalized Sepsis Treatment: Are We There Yet?
    Crit Care Med. 2021;49:1576-1582.
    PubMed    


  65. GUINAULT D, Nicolau-Travers ML, Silva S, Cointault O, et al
    Expression of Exhaustion Markers on CD8+ T-Cell Patterns Predict Outcomes in Septic Patients Admitted to the ICU.
    Crit Care Med. 2021;49:1513-1523.
    PubMed     Abstract available


    August 2021
  66. TARABICHI Y, Cheng A, Bar-Shain D, McCrate BM, et al
    Improving Timeliness of Antibiotic Administration Using a Provider and Pharmacist Facing Sepsis Early Warning System in the Emergency Department Setting: A Randomized Controlled Quality Improvement Initiative.
    Crit Care Med. 2021 Aug 20. pii: 00003246-900000000-95111.
    PubMed     Abstract available


  67. VALIK JK, Mellhammar L, Sunden-Cullberg J, Ward L, et al
    Peripheral Oxygen Saturation Facilitates Assessment of Respiratory Dysfunction in the Sequential Organ Failure Assessment Score With Implications for the Sepsis-3 Criteria.
    Crit Care Med. 2021 Aug 18. pii: 00003246-900000000-95113.
    PubMed     Abstract available


  68. TAKAYAMA W, Endo A, Morishita K, Otomo Y, et al
    Dielectric Blood Coagulometry for the Early Detection of Sepsis-Induced Disseminated Intravascular Coagulation: A Prospective Observational Study.
    Crit Care Med. 2021 Aug 9. pii: 00003246-900000000-95128.
    PubMed     Abstract available


  69. DELLINGER RP, Levy MM, Schorr CA, Townsend SR, et al
    50 Years of Sepsis Investigation/Enlightenment Among Adults-The Long and Winding Road.
    Crit Care Med. 2021 Aug 4. pii: 00003246-900000000-95133.
    PubMed    


  70. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Serum Agmatine Levels Were Negatively Correlated With the Severity of Sepsis: Beware of Potential Confounders!
    Crit Care Med. 2021;49:e810-e811.
    PubMed    


  71. PLOPPER GE, Sciarretta KL, Buchman TG
    Disparities in Sepsis Outcomes May Be Attributable to Access to Care.
    Crit Care Med. 2021;49:1358-1360.
    PubMed    


  72. PREST J, Sathananthan M, Jeganathan N
    Current Trends in Sepsis-Related Mortality in the United States.
    Crit Care Med. 2021;49:1276-1284.
    PubMed     Abstract available


  73. SHAH PK, Ginestra JC, Ungar LH, Junker P, et al
    A Simulated Prospective Evaluation of a Deep Learning Model for Real-Time Prediction of Clinical Deterioration Among Ward Patients.
    Crit Care Med. 2021;49:1312-1321.
    PubMed     Abstract available


  74. DESGROUAS M, Merdji H, Bretagnol A, Barin-Le Guellec C, et al
    Kinetic Glomerular Filtration Rate Equations in Patients With Shock: Comparison With the Iohexol-Based Gold-Standard Method.
    Crit Care Med. 2021;49:e761-e770.
    PubMed     Abstract available


    July 2021
  75. VAZQUEZ GUILLAMET MC, Dodda S, Liu L, Kollef MH, et al
    Race Does Not Impact Sepsis Outcomes When Considering Socioeconomic Factors in Multilevel Modeling.
    Crit Care Med. 2021 Jul 13. pii: 00003246-900000000-95151.
    PubMed     Abstract available


  76. SHAPPELL CN, Klompas M, Rhee C
    Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond.
    Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95161.
    PubMed    


  77. KARAKIKE E, Giamarellos-Bourboulis EJ, Kyprianou M, Fleischmann-Struzek C, et al
    Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95156.
    PubMed     Abstract available



  78. Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis: Erratum.
    Crit Care Med. 2021;49:e740.
    PubMed    


  79. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Higher Levels of S-100beta-a Biomarker of Astrocyte and Glial Activation Were Associated With a Greater Delirium Duration in Sepsis and Traumatic Brain Injury Patients: Beware of Some Confounders!
    Crit Care Med. 2021;49:e736-e737.
    PubMed    


  80. HONORE PM, Redant S, Preseau T, Kaefer K, et al
    Heparin-Binding Protein Performs Better for Detecting Sepsis Among Patients Presenting With Signs of Systemic Infection Compared With Procalcitonin, C-Reactive Protein, and Lactate Level, and Heparin-Binding Protein Is Sufficient for Both Ruling in an
    Crit Care Med. 2021;49:e733-e734.
    PubMed    


  81. STAUNTON O, Staunton C
    We Are Not Waiting for a Cure for Sepsis-We Are Waiting for Leadership.
    Crit Care Med. 2021;49:1192-1193.
    PubMed    


  82. SHAH AD, MacCallum NS, Harris S, Brealey DA, et al
    Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative.
    Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005169.
    PubMed     Abstract available


  83. HOLDER AL, Shashikumar SP, Wardi G, Buchman TG, et al
    A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU.
    Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005175.
    PubMed     Abstract available


  84. CHURPEK MM, Dumanian J, Dussault N, Bhavani SV, et al
    Determining the Electronic Signature of Infection in Electronic Health Record Data.
    Crit Care Med. 2021;49:e673-e682.
    PubMed     Abstract available


  85. YEHYA N, Fazelinia H, Lawrence GG, Spruce LA, et al
    Plasma Nucleosomes Are Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Med. 2021;49:1149-1158.
    PubMed     Abstract available


    June 2021
  86. ALRAWASHDEH M, Klompas M, Kimmel S, Larochelle MR, et al
    Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals.
    Crit Care Med. 2021 Jun 23. pii: 00003246-900000000-95191.
    PubMed     Abstract available


  87. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis and Septic Shock: Beware of Some Confounders!
    Crit Care Med. 2021;49:e659.
    PubMed    


  88. OXMAN DA
    Less Lumping and More Splitting: Why We Should Not Call COVID Sepsis.
    Crit Care Med. 2021;49:e656-e657.
    PubMed    


  89. PEJU E, Llitjos JF, Charpentier J, Francois A, et al
    Impact of Blood Product Transfusions on the Risk of ICU-Acquired Infections in Septic Shock.
    Crit Care Med. 2021;49:912-922.
    PubMed     Abstract available


    May 2021
  90. DE ROQUETAILLADE C, Mansouri S, Brumpt C, Neuwirth M, et al
    Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis.
    Crit Care Med. 2021 May 18. pii: 00003246-900000000-95220.
    PubMed     Abstract available


  91. GOETZ G, Hawlik K, Wild C
    Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis: An Update Systematic Review of Comparative Efficacy and Safety.
    Crit Care Med. 2021 May 3. pii: 00003246-900000000-95226.
    PubMed     Abstract available


  92. ABRAHAM E
    Moving Forward With Refinement of Definitions for Sepsis.
    Crit Care Med. 2021;49:861-863.
    PubMed    


  93. RHEE C, Heil EL
    Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis.
    Crit Care Med. 2021;49:858-860.
    PubMed    


    April 2021
  94. MOLINARI L, Heskia F, Peerapornratana S, Ronco C, et al
    Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
    Crit Care Med. 2021 Apr 30. pii: 00003246-900000000-95233.
    PubMed     Abstract available


  95. TAN K, Harazim M, Simpson A, Tan YC, et al
    Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes-The Beta-Blockers in European and Australian/American Septic Patients (BEAST) Study.
    Crit Care Med. 2021 Apr 28. doi: 10.1097/CCM.0000000000005034.
    PubMed     Abstract available


  96. DE CARVALHO LRP, Abreu SC, de Castro LL, Andrade da Silva LH, et al
    Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis.
    Crit Care Med. 2021 Apr 19. pii: 00003246-900000000-95254.
    PubMed     Abstract available


  97. OH TK, Park HY, Song IA
    Depression and Long-Term Survival Among South Korean Sepsis Survivors: A Nationwide Cohort Study From 2011 to 2014.
    Crit Care Med. 2021 Apr 8. pii: 00003246-900000000-95275.
    PubMed     Abstract available


  98. LAT I, Coopersmith CM, De Backer D
    The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
    Crit Care Med. 2021;49:623-635.
    PubMed     Abstract available


  99. CARR AC
    Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
    Crit Care Med. 2021;49:e477-e478.
    PubMed    


  100. JORRES A
    Initial Arterial Blood Pressure Targets in Patients With Septic Shock: One Size Fits All or Made to Measure?
    Crit Care Med. 2021;49:719-721.
    PubMed    


  101. DEMISELLE J, Seegers V, Lemerle M, Meziani F, et al
    Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target? A Post Hoc Analysis of the Sepsis and Mean Arterial Pressure (SEPSISPAM) Trial.
    Crit Care Med. 2021;49:e412-e422.
    PubMed     Abstract available


  102. HARIRI G, Urbina T, Lavillegrand JR, Gasperment M, et al
    Exaggerated Microvascular Vasodilating Responses in Cirrhotic Patients With Septic Shock.
    Crit Care Med. 2021;49:e404-e411.
    PubMed     Abstract available


    March 2021
  103. REN X
    Potential Endotype Transition for Coronavirus Disease 2019-Related Sepsis With Longitudinal Transcriptome Profiling.
    Crit Care Med. 2021 Mar 16. pii: 00003246-900000000-95304.
    PubMed    


  104. JONES TW, Azimi H, Scott C, Newsome AS, et al
    Does Norepinephrine Exhibit a Time-Dose Relationship in Septic Shock?
    Crit Care Med. 2021;49:e345-e346.
    PubMed    


    February 2021
  105. BORN S, Dame C, Matthaus-Kramer C, Schlapbach LJ, et al
    Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016.
    Crit Care Med. 2021 Feb 23. doi: 10.1097/CCM.0000000000004919.
    PubMed     Abstract available


  106. WANG HE, Kabeto MM, Gray M, Wadley VG, et al
    Trajectory of Cognitive Decline After Sepsis.
    Crit Care Med. 2021 Feb 18. doi: 10.1097/CCM.0000000000004897.
    PubMed     Abstract available


  107. TAYLOR SP, Anderson WE, Beam K, Taylor B, et al
    The Association Between Antibiotic Delay Intervals and Hospital Mortality Among Patients Treated in the Emergency Department for Suspected Sepsis.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95342.
    PubMed     Abstract available


  108. DEMERLE KM, Angus DC, Baillie JK, Brant E, et al
    Sepsis Subclasses: A Framework for Development and Interpretation.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95341.
    PubMed     Abstract available


  109. YU SC, Betthauser KD, Gupta A, Lyons PG, et al
    Comparison of Sepsis Definitions as Automated Criteria.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95354.
    PubMed     Abstract available


  110. COOPERSMITH CM, Antonelli M, Bauer SR, Deutschman CS, et al
    Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95348.
    PubMed     Abstract available


  111. BEESLEY SJ, Sorensen J, Walkey AJ, Tonna JE, et al
    Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95347.
    PubMed     Abstract available


  112. JACQUEMET PL, Schweizer R, Ruste M, Pozzi M, et al
    Venoarterial Extracorporeal Membranous Oxygenation Should Be Considered as an Appropriate Rescue Therapy for Sepsis-Induced Refractory Cardiogenic Shock.
    Crit Care Med. 2021;49:e210-e211.
    PubMed    


  113. MUNROE E, Prescott HC
    Late Mortality From Sepsis: What We Know and What It Means.
    Crit Care Med. 2021;49:353-355.
    PubMed    


  114. ROURKE EM, Kuttab HI, Lykins JD, Hughes MD, et al
    Fluid Resuscitation in Septic Patients With Comorbid Heart Failure.
    Crit Care Med. 2021;49:e201-e204.
    PubMed    


  115. TRIPATHI S, Kumar S, Kaushik S
    The Practice and Complications of Midline Catheters: A Systematic Review.
    Crit Care Med. 2021;49:e140-e150.
    PubMed     Abstract available


    January 2021
  116. ALHAZZANI W, Evans L, Alshamsi F, Moller MH, et al
    Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
    Crit Care Med. 2021 Jan 28. doi: 10.1097/CCM.0000000000004899.
    PubMed     Abstract available


  117. KELLUM JA, Artigas A, Gunnerson KJ, Honore PM, et al
    Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004845.
    PubMed     Abstract available


  118. LIZZA BD, Betthauser KD, Juang PH, Hampton NB, et al
    Racial Disparities in Readmissions Following Initial Hospitalization for Sepsis.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004809.
    PubMed     Abstract available


  119. BONAZZETTI C, Morena V, Giacomelli A, Oreni L, et al
    Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study.
    Crit Care Med. 2021;49:e31-e40.
    PubMed     Abstract available


  120. HANSON SJ, Patel N, Petersen TL, Feng M, et al
    The authors reply.
    Crit Care Med. 2021;49:e111-e112.
    PubMed    


  121. ARCOVERDE DE SOUSA D, Spessoto AB
    Peripherally Inserted Central Catheter Versus Central Venous Catheter: It Is Time to Use Different Approaches and Metrics for a More Useful Comparison.
    Crit Care Med. 2021;49:e109-e110.
    PubMed    


  122. BARANOWSKY A, Appelt J, Kleber C, Lange T, et al
    Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor.
    Crit Care Med. 2021;49:e41-e52.
    PubMed     Abstract available


  123. VERBOOM DM, van de Groep K, Boel CHE, Haas PJA, et al
    The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients.
    Crit Care Med. 2021;49:60-69.
    PubMed     Abstract available


  124. WONG HR, Hart KW, Lindsell CJ, Sweeney TE, et al
    External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients.
    Crit Care Med. 2021;49:e98-e101.
    PubMed     Abstract available


  125. SEVRANSKY JE, Agarwal A, Jabaley CS, Rochwerg B, et al
    Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients.
    Crit Care Med. 2021;49:151-155.
    PubMed    


    December 2020
  126. FARRAH K, McIntyre L, Doig CJ, Talarico R, et al
    Sepsis-Associated Mortality, Resource Use, and Healthcare Costs: A Propensity-Matched Cohort Study.
    Crit Care Med. 2020 Dec 17. doi: 10.1097/CCM.0000000000004777.
    PubMed     Abstract available


  127. PLATA-MENCHACA EP, Ferrer R
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis.
    Crit Care Med. 2020 Dec 8. doi: 10.1097/CCM.0000000000004776.
    PubMed    


  128. ROWE S, Alcheikh A
    Harm or Benefit of High-Dose Vitamin C in Adult Patients With Sepsis and Glucose-6-Phosphate Dehydrogenase Deficiency?
    Crit Care Med. 2020;48:e1356.
    PubMed    


  129. KADRI SS
    The Sepsis Proxy Pageant: Seeking Beauty in Imperfection.
    Crit Care Med. 2020;48:1917-1919.
    PubMed    


    November 2020
  130. LANKADEVA YR, Peiris RM, Okazaki N, Birchall IE, et al
    Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
    Crit Care Med. 2020 Nov 25. doi: 10.1097/CCM.0000000000004770.
    PubMed     Abstract available


  131. SWEENEY TE, Liesenfeld O, Wacker J, He YD, et al
    Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019.
    Crit Care Med. 2020 Nov 17. doi: 10.1097/CCM.0000000000004786.
    PubMed     Abstract available


  132. WU YL, Yo CH, Hsu WT, Qian F, et al
    Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2020 Nov 16. doi: 10.1097/CCM.0000000000004738.
    PubMed     Abstract available


  133. BANIASADI A, Rezaeirad S, Zare H, Ghassemi MM, et al
    Two-Step Imputation and AdaBoost-Based Classification for Early Prediction of Sepsis on Imbalanced Clinical Data.
    Crit Care Med. 2020 Nov 5. doi: 10.1097/CCM.0000000000004705.
    PubMed     Abstract available


    October 2020
  134. NESARAGI N, Patidar S
    Early Prediction of Sepsis From Clinical Data Using Ratio and Power-Based Features.
    Crit Care Med. 2020 Oct 13. doi: 10.1097/CCM.0000000000004691.
    PubMed     Abstract available


  135. HE Z, Du L, Zhang P, Zhao R, et al
    Early Sepsis Prediction Using Ensemble Learning With Deep Features and Artificial Features Extracted From Clinical Electronic Health Records.
    Crit Care Med. 2020 Oct 12. doi: 10.1097/CCM.0000000000004644.
    PubMed     Abstract available


  136. KEMPKER JA, Rudd KE, Wang HE, Martin GS, et al
    Sepsis Epidemiology Across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, Chasm-A Direct Application of the Institute for Health Metrics and Evaluation Case Definition to Hospital
    Crit Care Med. 2020 Oct 2. doi: 10.1097/CCM.0000000000004577.
    PubMed     Abstract available


    April 2020
  137. MATSUDA W
    Should We Restrict ICU Admission for Frail Septic Patients?
    Crit Care Med. 2020;48:e342-e343.
    PubMed    


  138. CARLTON EF, Prescott HC
    The authors reply.
    Crit Care Med. 2020;48:e334-e335.
    PubMed    


  139. PATEL S, Katanga JA, Burman S, Said H, et al
    Making Sense of Readmissions.
    Crit Care Med. 2020;48:e333-e334.
    PubMed    


  140. SWEENEY DA, Kalil AC
    Be Quick But Don't Hurry: Septic Shock, Staphylococcus aureus Bacteremia, and the Timing of Appropriate Antibiotics.
    Crit Care Med. 2020;48:608-609.
    PubMed    


  141. SILVA AYO, Amorim EA, Barbosa-Silva MC, Lima MN, et al
    Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice.
    Crit Care Med. 2020;48:e290-e298.
    PubMed     Abstract available


  142. CORL KA, Zeba F, Caffrey AR, Hermenau M, et al
    Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus aureus Bacteremia.
    Crit Care Med. 2020;48:525-532.
    PubMed     Abstract available


  143. LACHMANN G, Knaak C, Vorderwulbecke G, La Rosee P, et al
    Hyperferritinemia in Critically Ill Patients.
    Crit Care Med. 2020;48:459-465.
    PubMed     Abstract available


    March 2020
  144. KUTTAB HI, Ward MA
    The authors reply.
    Crit Care Med. 2020;48:e260-e261.
    PubMed    


  145. JONES TW, Finder S, Newsome AS, Smith SE, et al
    Getting to the Heart of the Matter: What We Know About Fluid Resuscitation in Septic Heart Failure Patients.
    Crit Care Med. 2020;48:e259-e260.
    PubMed    


  146. LAW AC, Stevens JP, Walkey AJ
    The authors reply.
    Crit Care Med. 2020;48:e249-e250.
    PubMed    


  147. OUD L
    Trends of Time to Hospital Mortality Versus Timing of Death Among Patients With Septic Shock in Administrative Data.
    Crit Care Med. 2020;48:e249.
    PubMed    


  148. MARRARO GA, Spada C, Zeng Y
    Administrative Database and Empiric Therapy Are Always Useful for Appropriate Treatment of Pediatric Patients?
    Crit Care Med. 2020;48:438-440.
    PubMed    


  149. JILANI SM, Giroir BP
    Septic Shock in Children: When Should Prevention Start and Treatment End?
    Crit Care Med. 2020;48:426-428.
    PubMed    


  150. ZADOR Z, Landry A, Balas M, Marshall JC, et al
    Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness.
    Crit Care Med. 2020;48:338-343.
    PubMed     Abstract available


  151. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:329-337.
    PubMed     Abstract available


  152. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:319-328.
    PubMed     Abstract available


  153. BELLETTI A, Nagy A, Sartorelli M, Mucchetti M, et al
    Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials.
    Crit Care Med. 2020;48:398-405.
    PubMed     Abstract available


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