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Articles published in Crit Care Med

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Single Articles


    December 2021
  1. HONORE PM, Redant S, Preseau T, Kaefer K, et al
    Procalcitonin as a Mediator in Sepsis: Are We Reinventing the Wheel?
    Crit Care Med. 2021;49:e1255-e1256.
    PubMed    


  2. KIMBALL SL, Levy MM
    Sepsis and the Opioid Crisis: Integrating Treatment for Two Public Health Emergencies.
    Crit Care Med. 2021;49:2151-2153.
    PubMed    


  3. BIBAN P, Marlow N, Te Pas AB, Fanaroff AA, et al
    Advances in Neonatal Critical Care: Pushing at the Boundaries and Connecting to Long-Term Outcomes.
    Crit Care Med. 2021;49:2003-2016.
    PubMed    


    November 2021
  4. RHEE C, Klompas M
    Conducting Sepsis Surveillance by Applying Sepsis-3 Criteria to Electronic Health Record Data: Promises and Potential Pitfalls.
    Crit Care Med. 2021;49:1983-1986.
    PubMed    


  5. EVANS L, Rhodes A, Alhazzani W, Antonelli M, et al
    Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.
    Crit Care Med. 2021;49:1974-1982.
    PubMed    


  6. MARTIN GS, Kane-Gill SL, Nadkarni V, Sorce LR, et al
    The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients.
    Crit Care Med. 2021;49:1849-1850.
    PubMed    


  7. SHAPPELL CN, Klompas M, Ochoa A, Rhee C, et al
    Likelihood of Bacterial Infection in Patients Treated With Broad-Spectrum IV Antibiotics in the Emergency Department.
    Crit Care Med. 2021;49:e1144-e1150.
    PubMed     Abstract available


    October 2021
  8. LEE HY, Lee J, Jung YS, Kwon WY, et al
    Preexisting Clinical Frailty Is Associated With Worse Clinical Outcomes in Patients With Sepsis.
    Crit Care Med. 2021 Oct 6. pii: 00003246-900000000-95052.
    PubMed     Abstract available


  9. MENON K, Schlapbach LJ, Akech S, Argent A, et al
    Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.
    Crit Care Med. 2021 Oct 6. pii: 00003246-900000000-95050.
    PubMed     Abstract available


  10. EVANS L, Rhodes A, Alhazzani W, Antonelli M, et al
    Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
    Crit Care Med. 2021 Oct 4. pii: 00003246-900000000-95059.
    PubMed    


  11. CHOTALIA M, Ali M, Hebballi R, Singh H, et al
    Hyperdynamic Left Ventricular Ejection Fraction in ICU Patients With Sepsis.
    Crit Care Med. 2021 Oct 4. pii: 00003246-900000000-95057.
    PubMed     Abstract available


  12. HAN X, Spicer A, Carey KA, Gilbert ER, et al
    Identifying High-Risk Subphenotypes and Associated Harms From Delayed Antibiotic Orders and Delivery.
    Crit Care Med. 2021;49:1694-1705.
    PubMed     Abstract available


    September 2021
  13. KHOWAJA AR, Willms AJ, Krause C, Carriere S, et al
    The Return on Investment of a Province-Wide Quality Improvement Initiative for Reducing In-Hospital Sepsis Rates and Mortality in British Columbia, Canada.
    Crit Care Med. 2021 Sep 29. pii: 00003246-900000000-95060.
    PubMed     Abstract available


  14. YU X, Chen J, Tang H, Tu Q, et al
    Identifying Prokineticin2 as a Novel Immunomodulatory Factor in Diagnosis and Treatment of Sepsis.
    Crit Care Med. 2021 Sep 27. pii: 00003246-900000000-95065.
    PubMed     Abstract available


  15. FRANK CE, Buchman TG, Simpson SQ, Sciarretta KL, et al
    Sepsis Among Medicare Beneficiaries: 4. Precoronavirus Disease 2019 Update January 2012-February 2020.
    Crit Care Med. 2021 Sep 27. pii: 00003246-900000000-95064.
    PubMed     Abstract available


  16. ASSOULINE B, Faivre A, Verissimo T, Sangla F, et al
    Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.
    Crit Care Med. 2021 Sep 27. pii: 00003246-900000000-95063.
    PubMed     Abstract available


  17. TAYLOR SP, Murphy S, Rios A, McWilliams A, et al
    Effect of a Multicomponent Sepsis Transition and Recovery Program on Mortality and Readmissions After Sepsis: The Improving Morbidity During Post-Acute Care Transitions for Sepsis Randomized Clinical Trial.
    Crit Care Med. 2021 Sep 16. pii: 00003246-900000000-95096.
    PubMed     Abstract available


  18. SATO R, Hasegawa D, Prasitlumkum N, Ueoka M, et al
    Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Crit Care Med. 2021 Sep 8. pii: 00003246-900000000-95105.
    PubMed     Abstract available


  19. YASUHARA S, Alston TA, Martyn JAJ
    Freshly Isolated Mitochondria as Therapeutic Agents in Sepsis: Can They Go Home Again?
    Crit Care Med. 2021;49:1584-1587.
    PubMed    


  20. KANTH SM, Torabi-Parizi P
    Personalized Sepsis Treatment: Are We There Yet?
    Crit Care Med. 2021;49:1576-1582.
    PubMed    


  21. GUINAULT D, Nicolau-Travers ML, Silva S, Cointault O, et al
    Expression of Exhaustion Markers on CD8+ T-Cell Patterns Predict Outcomes in Septic Patients Admitted to the ICU.
    Crit Care Med. 2021;49:1513-1523.
    PubMed     Abstract available


    August 2021
  22. TARABICHI Y, Cheng A, Bar-Shain D, McCrate BM, et al
    Improving Timeliness of Antibiotic Administration Using a Provider and Pharmacist Facing Sepsis Early Warning System in the Emergency Department Setting: A Randomized Controlled Quality Improvement Initiative.
    Crit Care Med. 2021 Aug 20. pii: 00003246-900000000-95111.
    PubMed     Abstract available


  23. VALIK JK, Mellhammar L, Sunden-Cullberg J, Ward L, et al
    Peripheral Oxygen Saturation Facilitates Assessment of Respiratory Dysfunction in the Sequential Organ Failure Assessment Score With Implications for the Sepsis-3 Criteria.
    Crit Care Med. 2021 Aug 18. pii: 00003246-900000000-95113.
    PubMed     Abstract available


  24. TAKAYAMA W, Endo A, Morishita K, Otomo Y, et al
    Dielectric Blood Coagulometry for the Early Detection of Sepsis-Induced Disseminated Intravascular Coagulation: A Prospective Observational Study.
    Crit Care Med. 2021 Aug 9. pii: 00003246-900000000-95128.
    PubMed     Abstract available


  25. DELLINGER RP, Levy MM, Schorr CA, Townsend SR, et al
    50 Years of Sepsis Investigation/Enlightenment Among Adults-The Long and Winding Road.
    Crit Care Med. 2021 Aug 4. pii: 00003246-900000000-95133.
    PubMed    


  26. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Serum Agmatine Levels Were Negatively Correlated With the Severity of Sepsis: Beware of Potential Confounders!
    Crit Care Med. 2021;49:e810-e811.
    PubMed    


  27. PLOPPER GE, Sciarretta KL, Buchman TG
    Disparities in Sepsis Outcomes May Be Attributable to Access to Care.
    Crit Care Med. 2021;49:1358-1360.
    PubMed    


  28. PREST J, Sathananthan M, Jeganathan N
    Current Trends in Sepsis-Related Mortality in the United States.
    Crit Care Med. 2021;49:1276-1284.
    PubMed     Abstract available


  29. SHAH PK, Ginestra JC, Ungar LH, Junker P, et al
    A Simulated Prospective Evaluation of a Deep Learning Model for Real-Time Prediction of Clinical Deterioration Among Ward Patients.
    Crit Care Med. 2021;49:1312-1321.
    PubMed     Abstract available


  30. DESGROUAS M, Merdji H, Bretagnol A, Barin-Le Guellec C, et al
    Kinetic Glomerular Filtration Rate Equations in Patients With Shock: Comparison With the Iohexol-Based Gold-Standard Method.
    Crit Care Med. 2021;49:e761-e770.
    PubMed     Abstract available


    July 2021
  31. VAZQUEZ GUILLAMET MC, Dodda S, Liu L, Kollef MH, et al
    Race Does Not Impact Sepsis Outcomes When Considering Socioeconomic Factors in Multilevel Modeling.
    Crit Care Med. 2021 Jul 13. pii: 00003246-900000000-95151.
    PubMed     Abstract available


  32. SHAPPELL CN, Klompas M, Rhee C
    Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond.
    Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95161.
    PubMed    


  33. KARAKIKE E, Giamarellos-Bourboulis EJ, Kyprianou M, Fleischmann-Struzek C, et al
    Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2021 Jul 12. pii: 00003246-900000000-95156.
    PubMed     Abstract available



  34. Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis: Erratum.
    Crit Care Med. 2021;49:e740.
    PubMed    


  35. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Higher Levels of S-100beta-a Biomarker of Astrocyte and Glial Activation Were Associated With a Greater Delirium Duration in Sepsis and Traumatic Brain Injury Patients: Beware of Some Confounders!
    Crit Care Med. 2021;49:e736-e737.
    PubMed    


  36. HONORE PM, Redant S, Preseau T, Kaefer K, et al
    Heparin-Binding Protein Performs Better for Detecting Sepsis Among Patients Presenting With Signs of Systemic Infection Compared With Procalcitonin, C-Reactive Protein, and Lactate Level, and Heparin-Binding Protein Is Sufficient for Both Ruling in an
    Crit Care Med. 2021;49:e733-e734.
    PubMed    


  37. STAUNTON O, Staunton C
    We Are Not Waiting for a Cure for Sepsis-We Are Waiting for Leadership.
    Crit Care Med. 2021;49:1192-1193.
    PubMed    


  38. SHAH AD, MacCallum NS, Harris S, Brealey DA, et al
    Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative.
    Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005169.
    PubMed     Abstract available


  39. HOLDER AL, Shashikumar SP, Wardi G, Buchman TG, et al
    A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU.
    Crit Care Med. 2021 Jul 1. doi: 10.1097/CCM.0000000000005175.
    PubMed     Abstract available


  40. CHURPEK MM, Dumanian J, Dussault N, Bhavani SV, et al
    Determining the Electronic Signature of Infection in Electronic Health Record Data.
    Crit Care Med. 2021;49:e673-e682.
    PubMed     Abstract available


  41. YEHYA N, Fazelinia H, Lawrence GG, Spruce LA, et al
    Plasma Nucleosomes Are Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Med. 2021;49:1149-1158.
    PubMed     Abstract available


    June 2021
  42. ALRAWASHDEH M, Klompas M, Kimmel S, Larochelle MR, et al
    Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals.
    Crit Care Med. 2021 Jun 23. pii: 00003246-900000000-95191.
    PubMed     Abstract available


  43. HONORE PM, Redant S, Kaefer K, Barreto Gutierrez L, et al
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis and Septic Shock: Beware of Some Confounders!
    Crit Care Med. 2021;49:e659.
    PubMed    


  44. OXMAN DA
    Less Lumping and More Splitting: Why We Should Not Call COVID Sepsis.
    Crit Care Med. 2021;49:e656-e657.
    PubMed    


  45. PEJU E, Llitjos JF, Charpentier J, Francois A, et al
    Impact of Blood Product Transfusions on the Risk of ICU-Acquired Infections in Septic Shock.
    Crit Care Med. 2021;49:912-922.
    PubMed     Abstract available


    May 2021
  46. DE ROQUETAILLADE C, Mansouri S, Brumpt C, Neuwirth M, et al
    Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis.
    Crit Care Med. 2021 May 18. pii: 00003246-900000000-95220.
    PubMed     Abstract available


  47. GOETZ G, Hawlik K, Wild C
    Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis: An Update Systematic Review of Comparative Efficacy and Safety.
    Crit Care Med. 2021 May 3. pii: 00003246-900000000-95226.
    PubMed     Abstract available


  48. ABRAHAM E
    Moving Forward With Refinement of Definitions for Sepsis.
    Crit Care Med. 2021;49:861-863.
    PubMed    


  49. RHEE C, Heil EL
    Toward More Rational Time-to-Antibiotic Metrics for Suspected Sepsis.
    Crit Care Med. 2021;49:858-860.
    PubMed    


    April 2021
  50. MOLINARI L, Heskia F, Peerapornratana S, Ronco C, et al
    Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
    Crit Care Med. 2021 Apr 30. pii: 00003246-900000000-95233.
    PubMed     Abstract available


  51. TAN K, Harazim M, Simpson A, Tan YC, et al
    Association Between Premorbid Beta-Blocker Exposure and Sepsis Outcomes-The Beta-Blockers in European and Australian/American Septic Patients (BEAST) Study.
    Crit Care Med. 2021 Apr 28. doi: 10.1097/CCM.0000000000005034.
    PubMed     Abstract available


  52. DE CARVALHO LRP, Abreu SC, de Castro LL, Andrade da Silva LH, et al
    Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis.
    Crit Care Med. 2021 Apr 19. pii: 00003246-900000000-95254.
    PubMed     Abstract available


  53. OH TK, Park HY, Song IA
    Depression and Long-Term Survival Among South Korean Sepsis Survivors: A Nationwide Cohort Study From 2011 to 2014.
    Crit Care Med. 2021 Apr 8. pii: 00003246-900000000-95275.
    PubMed     Abstract available


  54. LAT I, Coopersmith CM, De Backer D
    The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
    Crit Care Med. 2021;49:623-635.
    PubMed     Abstract available


  55. CARR AC
    Is "Mega-Dose" IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?
    Crit Care Med. 2021;49:e477-e478.
    PubMed    


  56. JORRES A
    Initial Arterial Blood Pressure Targets in Patients With Septic Shock: One Size Fits All or Made to Measure?
    Crit Care Med. 2021;49:719-721.
    PubMed    


  57. DEMISELLE J, Seegers V, Lemerle M, Meziani F, et al
    Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target? A Post Hoc Analysis of the Sepsis and Mean Arterial Pressure (SEPSISPAM) Trial.
    Crit Care Med. 2021;49:e412-e422.
    PubMed     Abstract available


  58. HARIRI G, Urbina T, Lavillegrand JR, Gasperment M, et al
    Exaggerated Microvascular Vasodilating Responses in Cirrhotic Patients With Septic Shock.
    Crit Care Med. 2021;49:e404-e411.
    PubMed     Abstract available


    March 2021
  59. REN X
    Potential Endotype Transition for Coronavirus Disease 2019-Related Sepsis With Longitudinal Transcriptome Profiling.
    Crit Care Med. 2021 Mar 16. pii: 00003246-900000000-95304.
    PubMed    


  60. JONES TW, Azimi H, Scott C, Newsome AS, et al
    Does Norepinephrine Exhibit a Time-Dose Relationship in Septic Shock?
    Crit Care Med. 2021;49:e345-e346.
    PubMed    


    February 2021
  61. BORN S, Dame C, Matthaus-Kramer C, Schlapbach LJ, et al
    Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016.
    Crit Care Med. 2021 Feb 23. doi: 10.1097/CCM.0000000000004919.
    PubMed     Abstract available


  62. WANG HE, Kabeto MM, Gray M, Wadley VG, et al
    Trajectory of Cognitive Decline After Sepsis.
    Crit Care Med. 2021 Feb 18. doi: 10.1097/CCM.0000000000004897.
    PubMed     Abstract available


  63. TAYLOR SP, Anderson WE, Beam K, Taylor B, et al
    The Association Between Antibiotic Delay Intervals and Hospital Mortality Among Patients Treated in the Emergency Department for Suspected Sepsis.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95342.
    PubMed     Abstract available


  64. DEMERLE KM, Angus DC, Baillie JK, Brant E, et al
    Sepsis Subclasses: A Framework for Development and Interpretation.
    Crit Care Med. 2021 Feb 15. pii: 00003246-900000000-95341.
    PubMed     Abstract available


  65. YU SC, Betthauser KD, Gupta A, Lyons PG, et al
    Comparison of Sepsis Definitions as Automated Criteria.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95354.
    PubMed     Abstract available


  66. COOPERSMITH CM, Antonelli M, Bauer SR, Deutschman CS, et al
    Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95348.
    PubMed     Abstract available


  67. BEESLEY SJ, Sorensen J, Walkey AJ, Tonna JE, et al
    Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis.
    Crit Care Med. 2021 Feb 12. pii: 00003246-900000000-95347.
    PubMed     Abstract available


  68. JACQUEMET PL, Schweizer R, Ruste M, Pozzi M, et al
    Venoarterial Extracorporeal Membranous Oxygenation Should Be Considered as an Appropriate Rescue Therapy for Sepsis-Induced Refractory Cardiogenic Shock.
    Crit Care Med. 2021;49:e210-e211.
    PubMed    


  69. MUNROE E, Prescott HC
    Late Mortality From Sepsis: What We Know and What It Means.
    Crit Care Med. 2021;49:353-355.
    PubMed    


  70. ROURKE EM, Kuttab HI, Lykins JD, Hughes MD, et al
    Fluid Resuscitation in Septic Patients With Comorbid Heart Failure.
    Crit Care Med. 2021;49:e201-e204.
    PubMed    


  71. TRIPATHI S, Kumar S, Kaushik S
    The Practice and Complications of Midline Catheters: A Systematic Review.
    Crit Care Med. 2021;49:e140-e150.
    PubMed     Abstract available


    January 2021
  72. ALHAZZANI W, Evans L, Alshamsi F, Moller MH, et al
    Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.
    Crit Care Med. 2021 Jan 28. doi: 10.1097/CCM.0000000000004899.
    PubMed     Abstract available


  73. KELLUM JA, Artigas A, Gunnerson KJ, Honore PM, et al
    Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004845.
    PubMed     Abstract available


  74. LIZZA BD, Betthauser KD, Juang PH, Hampton NB, et al
    Racial Disparities in Readmissions Following Initial Hospitalization for Sepsis.
    Crit Care Med. 2021 Jan 20. doi: 10.1097/CCM.0000000000004809.
    PubMed     Abstract available


  75. BONAZZETTI C, Morena V, Giacomelli A, Oreni L, et al
    Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study.
    Crit Care Med. 2021;49:e31-e40.
    PubMed     Abstract available


  76. HANSON SJ, Patel N, Petersen TL, Feng M, et al
    The authors reply.
    Crit Care Med. 2021;49:e111-e112.
    PubMed    


  77. ARCOVERDE DE SOUSA D, Spessoto AB
    Peripherally Inserted Central Catheter Versus Central Venous Catheter: It Is Time to Use Different Approaches and Metrics for a More Useful Comparison.
    Crit Care Med. 2021;49:e109-e110.
    PubMed    


  78. BARANOWSKY A, Appelt J, Kleber C, Lange T, et al
    Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor.
    Crit Care Med. 2021;49:e41-e52.
    PubMed     Abstract available


  79. VERBOOM DM, van de Groep K, Boel CHE, Haas PJA, et al
    The Diagnostic Yield of Routine Admission Blood Cultures in Critically Ill Patients.
    Crit Care Med. 2021;49:60-69.
    PubMed     Abstract available


  80. WONG HR, Hart KW, Lindsell CJ, Sweeney TE, et al
    External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients.
    Crit Care Med. 2021;49:e98-e101.
    PubMed     Abstract available


  81. SEVRANSKY JE, Agarwal A, Jabaley CS, Rochwerg B, et al
    Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients.
    Crit Care Med. 2021;49:151-155.
    PubMed    


    December 2020
  82. FARRAH K, McIntyre L, Doig CJ, Talarico R, et al
    Sepsis-Associated Mortality, Resource Use, and Healthcare Costs: A Propensity-Matched Cohort Study.
    Crit Care Med. 2020 Dec 17. doi: 10.1097/CCM.0000000000004777.
    PubMed     Abstract available


  83. PLATA-MENCHACA EP, Ferrer R
    Procalcitonin Is Useful for Antibiotic Deescalation in Sepsis.
    Crit Care Med. 2020 Dec 8. doi: 10.1097/CCM.0000000000004776.
    PubMed    


  84. ROWE S, Alcheikh A
    Harm or Benefit of High-Dose Vitamin C in Adult Patients With Sepsis and Glucose-6-Phosphate Dehydrogenase Deficiency?
    Crit Care Med. 2020;48:e1356.
    PubMed    


  85. KADRI SS
    The Sepsis Proxy Pageant: Seeking Beauty in Imperfection.
    Crit Care Med. 2020;48:1917-1919.
    PubMed    


    November 2020
  86. LANKADEVA YR, Peiris RM, Okazaki N, Birchall IE, et al
    Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C.
    Crit Care Med. 2020 Nov 25. doi: 10.1097/CCM.0000000000004770.
    PubMed     Abstract available


  87. SWEENEY TE, Liesenfeld O, Wacker J, He YD, et al
    Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019.
    Crit Care Med. 2020 Nov 17. doi: 10.1097/CCM.0000000000004786.
    PubMed     Abstract available


  88. WU YL, Yo CH, Hsu WT, Qian F, et al
    Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2020 Nov 16. doi: 10.1097/CCM.0000000000004738.
    PubMed     Abstract available


  89. BANIASADI A, Rezaeirad S, Zare H, Ghassemi MM, et al
    Two-Step Imputation and AdaBoost-Based Classification for Early Prediction of Sepsis on Imbalanced Clinical Data.
    Crit Care Med. 2020 Nov 5. doi: 10.1097/CCM.0000000000004705.
    PubMed     Abstract available


    October 2020
  90. NESARAGI N, Patidar S
    Early Prediction of Sepsis From Clinical Data Using Ratio and Power-Based Features.
    Crit Care Med. 2020 Oct 13. doi: 10.1097/CCM.0000000000004691.
    PubMed     Abstract available


  91. HE Z, Du L, Zhang P, Zhao R, et al
    Early Sepsis Prediction Using Ensemble Learning With Deep Features and Artificial Features Extracted From Clinical Electronic Health Records.
    Crit Care Med. 2020 Oct 12. doi: 10.1097/CCM.0000000000004644.
    PubMed     Abstract available


  92. KEMPKER JA, Rudd KE, Wang HE, Martin GS, et al
    Sepsis Epidemiology Across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, Chasm-A Direct Application of the Institute for Health Metrics and Evaluation Case Definition to Hospital
    Crit Care Med. 2020 Oct 2. doi: 10.1097/CCM.0000000000004577.
    PubMed     Abstract available


  93. SCOTT HF, Brilli RJ, Paul R, Macias CG, et al
    Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement.
    Crit Care Med. 2020;48:e916-e926.
    PubMed     Abstract available


  94. LI X, Xu X, Xie F, Xu X, et al
    A Time-Phased Machine Learning Model for Real-Time Prediction of Sepsis in Critical Care.
    Crit Care Med. 2020;48:e884-e888.
    PubMed     Abstract available


  95. PARK S, Jeon K, Oh DK, Choi EY, et al
    Normothermia in Patients With Sepsis Who Present to Emergency Departments Is Associated With Low Compliance With Sepsis Bundles and Increased In-Hospital Mortality Rate.
    Crit Care Med. 2020;48:1462-1470.
    PubMed     Abstract available


  96. BOURNE DS, Davis BS, Gigli KH, Chang CH, et al
    Economic Analysis of Mandated Protocolized Sepsis Care in New York Hospitals.
    Crit Care Med. 2020;48:1411-1418.
    PubMed     Abstract available


  97. SCHLAPBACH LJ, Watson RS
    Adapting Pediatric Sepsis Criteria for Benchmarking and Quality Control - The Search for the Holy Grail Continues.
    Crit Care Med. 2020;48:1549-1551.
    PubMed    


  98. WALLEY KR, Boyd JH
    Lipoprotein Biology in Sepsis.
    Crit Care Med. 2020;48:1547-1549.
    PubMed    


  99. NOEL C, Schorr C
    Normothermia in Sepsis Warrants More Than a Lukewarm Response.
    Crit Care Med. 2020;48:1538-1540.
    PubMed    


    September 2020
  100. BHAVANI SV, Wolfe KS, Hrusch CL, Greenberg JA, et al
    Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.
    Crit Care Med. 2020 Sep 17. doi: 10.1097/CCM.0000000000004610.
    PubMed     Abstract available


    August 2020
  101. SHAPPELL CN, Klompas M, Rhee C
    Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?
    Crit Care Med. 2020 Aug 24. doi: 10.1097/CCM.0000000000004601.
    PubMed    


  102. BELTRAN-GARCIA J, Osca-Verdegal R, Pallardo FV, Ferreres J, et al
    Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches.
    Crit Care Med. 2020 Aug 18. doi: 10.1097/CCM.0000000000004625.
    PubMed     Abstract available


  103. YANG M, Liu C, Wang X, Li Y, et al
    An Explainable Artificial Intelligence Predictor for Early Detection of Sepsis.
    Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004550.
    PubMed     Abstract available


  104. MAVES RC
    Procalcitonin Is Not an Adequate Tool for Antimicrobial De-Escalation in Sepsis.
    Crit Care Med. 2020 Aug 6. doi: 10.1097/CCM.0000000000004547.
    PubMed    


  105. MORRILL JH, Kormilitzin A, Nevado-Holgado AJ, Swaminathan S, et al
    Utilization of the Signature Method to Identify the Early Onset of Sepsis From Multivariate Physiological Time Series in Critical Care Monitoring.
    Crit Care Med. 2020 Aug 3. doi: 10.1097/CCM.0000000000004510.
    PubMed     Abstract available


  106. SATO R, Kuriyama A
    Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
    Crit Care Med. 2020;48:e722-e729.
    PubMed     Abstract available


  107. DEUTSCHMAN CS, Hellman J, Ferrer Roca R, De Backer D, et al
    The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities.
    Crit Care Med. 2020;48:1217-1232.
    PubMed     Abstract available


  108. GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
    Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
    Crit Care Med. 2020;48:1175-1179.
    PubMed     Abstract available


  109. LEVI M, Vincent JL, Tanaka K, Radford AH, et al
    Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
    Crit Care Med. 2020;48:1140-1147.
    PubMed     Abstract available


    July 2020
  110. BUSCH LM, Sun J, Eichacker PQ, Torabi-Parizi P, et al
    Inhibitory Immune Checkpoint Molecule Expression in Clinical Sepsis Studies: A Systematic Review.
    Crit Care Med. 2020 Jul 20. doi: 10.1097/CCM.0000000000004496.
    PubMed     Abstract available


  111. ZHOU Y, Xu W, Shao A
    Application Prospect of Mesenchymal Stem Cells in the Treatment of Sepsis.
    Crit Care Med. 2020;48:e634.
    PubMed    


  112. SCHINKEL M, Boerman AW, Nanayakkara PWB
    A Different Perspective on the Use of Sepsis Alert.
    Crit Care Med. 2020;48:e632-e633.
    PubMed    


  113. BARBASH IJ
    Disparities in Sepsis Outcomes: A Problem in Need of Solutions.
    Crit Care Med. 2020;48:1079-1080.
    PubMed    


    June 2020
  114. JAGAN N, Morrow LE, Walters RW, Plambeck RW, et al
    Sepsis and the Obesity Paradox: Size Matters in More Than One Way.
    Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004459.
    PubMed     Abstract available


  115. EGUIA E, Bunn C, Kulshrestha S, Markossian T, et al
    Trends, Cost, and Mortality From Sepsis After Trauma in the United States: An Evaluation of the National Inpatient Sample of Hospitalizations, 2012-2016.
    Crit Care Med. 2020 Jun 25. doi: 10.1097/CCM.0000000000004451.
    PubMed     Abstract available


  116. ENGOREN M, Seelhammer T, Freundlich RE, Maile MD, et al
    A Comparison of Sepsis-2 (Systemic Inflammatory Response Syndrome Based) to Sepsis-3 (Sequential Organ Failure Assessment Based) Definitions-A Multicenter Retrospective Study.
    Crit Care Med. 2020 Jun 22. doi: 10.1097/CCM.0000000000004449.
    PubMed     Abstract available


  117. SATO R, Kuriyama A
    Venoarterial Extracorporeal Membranous Oxygenation: Treatment Option for Sepsis-Induced Cardiogenic Shock? A Systematic Review.
    Crit Care Med. 2020 Jun 12. doi: 10.1097/CCM.0000000000004432.
    PubMed     Abstract available


  118. GREGOROWICZ AJ, Costello PG, Gajdosik DA, Purakal J, et al
    Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis.
    Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004430.
    PubMed     Abstract available


  119. LEVI M, Vincent JL, Tanaka K, Radford AH, et al
    Effect of a Recombinant Human Soluble Thrombomodulin on Baseline Coagulation Biomarker Levels and Mortality Outcome in Patients With Sepsis-Associated Coagulopathy.
    Crit Care Med. 2020 Jun 11. doi: 10.1097/CCM.0000000000004426.
    PubMed     Abstract available


  120. CAWCUTT KA, Beachy M, Peitz GJ
    Antibiotic Delivery in Sepsis: How Do We Improve?
    Crit Care Med. 2020;48:e540-e541.
    PubMed    


  121. COOKSLEY T, Haji-Michael P
    Oncologic Sepsis on the ICU: Two Decades of Improving Outcomes.
    Crit Care Med. 2020;48:925-926.
    PubMed    


  122. SEE H, Slonim AD
    Evaluating the Effect of Policy Changes on Sepsis Outcomes.
    Crit Care Med. 2020;48:919-920.
    PubMed    


  123. RHEE C, Strich JR, Klompas M, Yealy DM, et al
    SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care...But Now Is the Time to Improve SEP-1.
    Crit Care Med. 2020;48:779-782.
    PubMed    


    May 2020
  124. EHLER J, Petzold A, Sharshar T, Ely EW, et al
    Biomarker Panel to Differentiate Brain Injury From Brain Dysfunction in Patients With Sepsis-Associated Encephalopathy.
    Crit Care Med. 2020;48:e436-e437.
    PubMed    


    April 2020
  125. RUSH B, Danziger J, Walley KR, Kumar A, et al
    Treatment in Disproportionately Minority Hospitals Is Associated With Increased Risk of Mortality in Sepsis: A National Analysis.
    Crit Care Med. 2020 Apr 28. doi: 10.1097/CCM.0000000000004375.
    PubMed     Abstract available


  126. OSBORN TM
    Sepsis Mandates Help Clinicians and Patients.
    Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004342.
    PubMed    


  127. LEMIALE V, Pons S, Mirouse A, Tudesq JJ, et al
    Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique Study.
    Crit Care Med. 2020 Apr 17. doi: 10.1097/CCM.0000000000004322.
    PubMed     Abstract available


  128. LINDELL RB, Nishisaki A, Weiss SL, Traynor DM, et al
    Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock.
    Crit Care Med. 2020 Apr 14. doi: 10.1097/CCM.0000000000004329.
    PubMed     Abstract available


  129. CHINAI B, Gaughan J, Schorr C
    Implementation of the Affordable Care Act: A Comparison of Outcomes in Patients With Severe Sepsis and Septic Shock Using the National Inpatient Sample.
    Crit Care Med. 2020 Apr 9. doi: 10.1097/CCM.0000000000004310.
    PubMed     Abstract available


  130. GALIATSATOS P, Follin A, Alghanim F, Sherry M, et al
    The Association Between Neighborhood Socioeconomic Disadvantage and Readmissions for Patients Hospitalized With Sepsis.
    Crit Care Med. 2020 Apr 8. doi: 10.1097/CCM.0000000000004307.
    PubMed     Abstract available


  131. STRICH JR, Wang J, Eichacker PQ
    Sepsis Bundles That Focus on Clinician Judgment and Proven Interventions Are Needed to Increase Bundle Compliance and Effectiveness.
    Crit Care Med. 2020;48:602-605.
    PubMed    


  132. ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
    Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
    Crit Care Med. 2020;48:484-490.
    PubMed     Abstract available


  133. MATSUDA W
    Should We Restrict ICU Admission for Frail Septic Patients?
    Crit Care Med. 2020;48:e342-e343.
    PubMed    


  134. CARLTON EF, Prescott HC
    The authors reply.
    Crit Care Med. 2020;48:e334-e335.
    PubMed    


  135. PATEL S, Katanga JA, Burman S, Said H, et al
    Making Sense of Readmissions.
    Crit Care Med. 2020;48:e333-e334.
    PubMed    


  136. SWEENEY DA, Kalil AC
    Be Quick But Don't Hurry: Septic Shock, Staphylococcus aureus Bacteremia, and the Timing of Appropriate Antibiotics.
    Crit Care Med. 2020;48:608-609.
    PubMed    


  137. SILVA AYO, Amorim EA, Barbosa-Silva MC, Lima MN, et al
    Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice.
    Crit Care Med. 2020;48:e290-e298.
    PubMed     Abstract available


  138. CORL KA, Zeba F, Caffrey AR, Hermenau M, et al
    Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus aureus Bacteremia.
    Crit Care Med. 2020;48:525-532.
    PubMed     Abstract available


  139. LACHMANN G, Knaak C, Vorderwulbecke G, La Rosee P, et al
    Hyperferritinemia in Critically Ill Patients.
    Crit Care Med. 2020;48:459-465.
    PubMed     Abstract available


    March 2020
  140. ALHAZZANI W, Moller MH, Arabi YM, Loeb M, et al
    Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).
    Crit Care Med. 2020 Mar 27. doi: 10.1097/CCM.0000000000004363.
    PubMed     Abstract available


  141. HENDRICKSON CM, Matthay MA
    Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults.
    Crit Care Med. 2020;48:428-430.
    PubMed    


  142. BUSCH LM, Kalil AC, Kadri SS
    Predicting Sepsis Mortality and Costs Using Medicare Claims: A Method to the Madness.
    Crit Care Med. 2020;48:424-426.
    PubMed    


  143. LEVY MM
    Identifying the Burden of Sepsis With Big Data.
    Crit Care Med. 2020;48:422-423.
    PubMed    


  144. RHEE C, Klompas M
    The Eye-Popping Costs Associated With Sepsis Diagnoses Among Medicare Beneficiaries.
    Crit Care Med. 2020;48:420-422.
    PubMed    


  145. WHITNEY JE, Zhang B, Koterba N, Chen F, et al
    Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.
    Crit Care Med. 2020;48:344-352.
    PubMed     Abstract available


  146. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:302-318.
    PubMed     Abstract available


  147. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:289-301.
    PubMed     Abstract available


  148. BUCHMAN TG, Simpson SQ, Sciarretta KL, Finne KP, et al
    Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018.
    Crit Care Med. 2020;48:276-288.
    PubMed     Abstract available


  149. KUTTAB HI, Ward MA
    The authors reply.
    Crit Care Med. 2020;48:e260-e261.
    PubMed    


  150. JONES TW, Finder S, Newsome AS, Smith SE, et al
    Getting to the Heart of the Matter: What We Know About Fluid Resuscitation in Septic Heart Failure Patients.
    Crit Care Med. 2020;48:e259-e260.
    PubMed    


  151. LAW AC, Stevens JP, Walkey AJ
    The authors reply.
    Crit Care Med. 2020;48:e249-e250.
    PubMed    


  152. OUD L
    Trends of Time to Hospital Mortality Versus Timing of Death Among Patients With Septic Shock in Administrative Data.
    Crit Care Med. 2020;48:e249.
    PubMed    


  153. MARRARO GA, Spada C, Zeng Y
    Administrative Database and Empiric Therapy Are Always Useful for Appropriate Treatment of Pediatric Patients?
    Crit Care Med. 2020;48:438-440.
    PubMed    


  154. JILANI SM, Giroir BP
    Septic Shock in Children: When Should Prevention Start and Treatment End?
    Crit Care Med. 2020;48:426-428.
    PubMed    


  155. ZADOR Z, Landry A, Balas M, Marshall JC, et al
    Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness.
    Crit Care Med. 2020;48:338-343.
    PubMed     Abstract available


  156. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:329-337.
    PubMed     Abstract available


  157. ZIMMERMAN JJ, Banks R, Berg RA, Zuppa A, et al
    Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.
    Crit Care Med. 2020;48:319-328.
    PubMed     Abstract available


  158. BELLETTI A, Nagy A, Sartorelli M, Mucchetti M, et al
    Effect of Continuous Epinephrine Infusion on Survival in Critically Ill Patients: A Meta-Analysis of Randomized Trials.
    Crit Care Med. 2020;48:398-405.
    PubMed     Abstract available


    February 2020
  159. CARLTON EF, Donnelly JP, Hensley MK, Cornell TT, et al
    New Medical Device Acquisition During Pediatric Severe Sepsis Hospitalizations.
    Crit Care Med. 2020 Feb 27. doi: 10.1097/CCM.0000000000004272.
    PubMed     Abstract available


  160. BINNIE A, Tsang JLY, Hu P, Carrasqueiro G, et al
    Epigenetics of Sepsis.
    Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004247.
    PubMed     Abstract available


  161. KWON MY, Ghanta S, Ng J, Tsoyi K, et al
    Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
    Crit Care Med. 2020 Feb 20. doi: 10.1097/CCM.0000000000004244.
    PubMed     Abstract available


  162. ISHII J, Ohshimo S, Shime N
    Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program.
    Crit Care Med. 2020;48:e161-e162.
    PubMed    


  163. BUCHMAN TG, Zehnbauer BA
    Exploring the Epigenetics of Severe Sepsis: First Step in a Long Journey.
    Crit Care Med. 2020;48:254-255.
    PubMed    


  164. REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
    Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
    Crit Care Med. 2020;48:210-217.
    PubMed     Abstract available


  165. PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
    Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2020;48:200-209.
    PubMed     Abstract available


  166. BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
    Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
    Crit Care Med. 2020;48:142-150.
    PubMed     Abstract available


  167. SARIA S, Henry KE
    Too Many Definitions of Sepsis: Can Machine Learning Leverage the Electronic Health Record to Increase Accuracy and Bring Consensus?
    Crit Care Med. 2020;48:137-141.
    PubMed    


  168. AFSHAR M, Markossian T, Joyce C
    The authors reply.
    Crit Care Med. 2020;48:e162-e163.
    PubMed    


    January 2020
  169. ROSENQVIST M, Bengtsson-Toni M, Tham J, Lanbeck P, et al
    Improved Outcomes After Regional Implementation of Sepsis Alert: A Novel Triage Model.
    Crit Care Med. 2020 Jan 13. doi: 10.1097/CCM.0000000000004179.
    PubMed     Abstract available


  170. LEMASLE L, Blet A, Geven C, Cherifa M, et al
    Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
    Crit Care Med. 2020;48:49-55.
    PubMed     Abstract available


    December 2019
  171. REYNA MA, Josef CS, Jeter R, Shashikumar SP, et al
    Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.
    Crit Care Med. 2019 Dec 17. doi: 10.1097/CCM.0000000000004145.
    PubMed     Abstract available


  172. BINNIE A, Walsh CJ, Hu P, Dwivedi DJ, et al
    Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
    Crit Care Med. 2019 Dec 11. doi: 10.1097/CCM.0000000000004097.
    PubMed     Abstract available


  173. XIE J, Wang H, Kang Y, Zhou L, et al
    The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey.
    Crit Care Med. 2019 Dec 5. doi: 10.1097/CCM.0000000000004155.
    PubMed     Abstract available


  174. PRASAD PA, Fang MC, Abe-Jones Y, Calfee CS, et al
    Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
    Crit Care Med. 2019 Dec 3. doi: 10.1097/CCM.0000000000004132.
    PubMed     Abstract available


  175. OUD L
    The Impact of Atrial Fibrillation on Short-Term Mortality and Resource Utilization in Sepsis.
    Crit Care Med. 2019;47:e1032.
    PubMed    


    November 2019
  176. PROUT AJ, Talisa VB, Carcillo JA, Decker BK, et al
    Bacterial and Fungal Etiology of Sepsis in Children in the United States: Reconsidering Empiric Therapy.
    Crit Care Med. 2019 Nov 27. doi: 10.1097/CCM.0000000000004140.
    PubMed     Abstract available


  177. SHUBIN NJ, Navalkar K, Sampson D, Yager TD, et al
    Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
    Crit Care Med. 2019 Nov 8. doi: 10.1097/CCM.0000000000004083.
    PubMed     Abstract available


  178. OSUCHOWSKI MF, Rosengart MR
    Change Is the Only Constant: How to Adopt the New Trends in Sepsis Modeling?
    Crit Care Med. 2019;47:1673-1675.
    PubMed    


  179. HOPKINS RO
    Acquired Brain Injury Following Sepsis.
    Crit Care Med. 2019;47:1658-1659.
    PubMed    


  180. SIMPSON SQ
    Sepsis Biomarkers and Physician Judgment in the Emergency Room.
    Crit Care Med. 2019;47:1656-1657.
    PubMed    


    October 2019
  181. SHIMADA T, Topchiy E, Leung AKK, Kong HJ, et al
    Very Low Density Lipoprotein Receptor Sequesters Lipopolysaccharide Into Adipose Tissue During Sepsis.
    Crit Care Med. 2019 Oct 23. doi: 10.1097/CCM.0000000000004064.
    PubMed     Abstract available


  182. LI X, Zhu J, Tian L, Ma X, et al
    Agmatine Protects Against the Progression of Sepsis Through the Imidazoline I2 Receptor-Ribosomal S6 Kinase 2-Nuclear Factor-kappaB Signaling Pathway.
    Crit Care Med. 2019 Oct 21. doi: 10.1097/CCM.0000000000004065.
    PubMed     Abstract available


  183. YAN X, Tu H, Liu Y, Chen T, et al
    Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis.
    Crit Care Med. 2019 Oct 17. doi: 10.1097/CCM.0000000000004070.
    PubMed     Abstract available


  184. NUSSHAG C, Rupp C, Schmitt F, Krautkramer E, et al
    Cell Cycle Biomarkers and Soluble Urokinase-Type Plasminogen Activator Receptor for the Prediction of Sepsis-Induced Acute Kidney Injury Requiring Renal Replacement Therapy: A Prospective, Exploratory Study.
    Crit Care Med. 2019 Oct 4. doi: 10.1097/CCM.0000000000004042.
    PubMed     Abstract available


    September 2019
  185. OH SY, Cho S, Kim GH, Jang EJ, et al
    Incidence and Outcomes of Sepsis in Korea: A Nationwide Cohort Study From 2007 to 2016.
    Crit Care Med. 2019 Sep 30. doi: 10.1097/CCM.0000000000004041.
    PubMed     Abstract available


    July 2019
  186. BEALE R
    Enough Is As Good As a Feast.
    Crit Care Med. 2019;47:1004-1006.
    PubMed    


  187. MUTHUMALAIAPPAN K
    Efficacy of Mesenchymal Stem/Stromal Cell Infusion in Septic Patients Is a Puzzle Worthy of Attention.
    Crit Care Med. 2019;47:1001-1002.
    PubMed    


  188. TAPIA P, Gatica S, Cortes-Rivera C, Otero C, et al
    Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.
    Crit Care Med. 2019;47:942-950.
    PubMed     Abstract available


  189. SCHLOSSER K, Wang JP, Dos Santos C, Walley KR, et al
    Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.
    Crit Care Med. 2019;47:918-925.
    PubMed     Abstract available


    June 2019
  190. LI S, Wang S, Priyanka P, Kellum JA, et al
    Acute Kidney Injury in Critically Ill Patients After Noncardiac Major Surgery: Early Versus Late Onset.
    Crit Care Med. 2019;47:e437-e444.
    PubMed     Abstract available


    May 2019
  191. WOOLUM JA, Flannery AH
    The authors reply.
    Crit Care Med. 2019;47:e435-e436.
    PubMed    


  192. PATEL JJ, Bergl P
    Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.
    Crit Care Med. 2019;47:e434-e435.
    PubMed    


  193. MORELLI A, Sanfilippo F, Rehberg S, Ertmer C, et al
    The authors reply.
    Crit Care Med. 2019;47:e432-e433.
    PubMed    


  194. PETITJEANS F, Leroy S, Geloen A, Pichot C, et al
    On the Right Track, Finally?
    Crit Care Med. 2019;47:e431-e432.
    PubMed    


  195. ROSSAINT J, Zarbock A
    A Novel Approach for the Targeted Inhibition of Platelet Activation-Separating the Good From the Bad.
    Crit Care Med. 2019;47:741-743.
    PubMed    


  196. GRUMAZ S, Grumaz C, Vainshtein Y, Stevens P, et al
    Enhanced Performance of Next-Generation Sequencing Diagnostics Compared With Standard of Care Microbiological Diagnostics in Patients Suffering From Septic Shock.
    Crit Care Med. 2019;47:e394-e402.
    PubMed     Abstract available


    April 2019
  197. FISHER J, Linder A, Caironi P, Russell JA, et al
    The authors reply.
    Crit Care Med. 2019;47:e378-e379.
    PubMed    


  198. MENARD CE, Kumar A, Houston DS, Turgeon AF, et al
    Evolution and Impact of Thrombocytopenia in Septic Shock: A Retrospective Cohort Study.
    Crit Care Med. 2019;47:558-565.
    PubMed     Abstract available


  199. LEIJTE GP, Kiers D, van der Heijden W, Jansen A, et al
    Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.
    Crit Care Med. 2019;47:508-516.
    PubMed     Abstract available


    March 2019
  200. KELLY BJ, Lautenbach E, Han JH
    The authors reply.
    Crit Care Med. 2019;47:e275-e276.
    PubMed    


  201. PATNAIK R, Gurjar M
    Is Combined Biomarkers a Future Tool for Early Prediction of Mortality Among Septic Patients?
    Crit Care Med. 2019;47:e275.
    PubMed    


  202. REDFERN OC, Smith GB, Prytherch DR, Meredith P, et al
    The authors reply.
    Crit Care Med. 2019;47:e266-e267.
    PubMed    


    February 2019
  203. OCZKOWSKI SJ, Rochwerg B, Alhazzani W, Siemieniuk RAC, et al
    The authors reply.
    Crit Care Med. 2019;47:e158-e159.
    PubMed    


  204. WOOLUM JA, Flannery AH
    The authors reply.
    Crit Care Med. 2019;47:e154.
    PubMed    


  205. OLANIPEKUN TO, Bakinde N, Effoe VS, Snyder R, et al
    Further Considerations on the Benefits of Thiamine Administration in Patients With Septic Shock.
    Crit Care Med. 2019;47:e153-e154.
    PubMed    


  206. MORELLI A, Sanfilippo F, Arnemann P, Hessler M, et al
    The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.
    Crit Care Med. 2019;47:e89-e95.
    PubMed     Abstract available


    January 2019
  207. LANKADEVA YR, Kosaka J, Iguchi N, Evans RG, et al
    Effects of Fluid Bolus Therapy on Renal Perfusion, Oxygenation, and Function in Early Experimental Septic Kidney Injury.
    Crit Care Med. 2019;47:e36-e43.
    PubMed     Abstract available


  208. LU C, Liu Q, Yuan H, Wang L, et al
    Implementation of the Smart Use of Antibiotics Program to Reduce Unnecessary Antibiotic Use in a Neonatal ICU: A Prospective Interrupted Time-Series Study in a Developing Country.
    Crit Care Med. 2019;47:e1-e7.
    PubMed     Abstract available


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