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Articles published in Crit Care Med

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Single Articles


    June 2018
  1. LEVY MM, Evans LE, Rhodes A
    The Surviving Sepsis Campaign Bundle: 2018 Update.
    Crit Care Med. 2018;46:997-1000.
    PubMed     Text format    


  2. JACOBS MC, Wiersinga WJ
    Interleukin-34: A New Player in the Sepsis Arena.
    Crit Care Med. 2018;46:1032-1033.
    PubMed     Text format    


  3. PROWLE JR
    Renal Blood Flow Measurement in Early Clinical Sepsis-Can You Catch a Shadow?
    Crit Care Med. 2018;46:1028-1030.
    PubMed     Text format    


  4. SHANKAR-HARI M, Rubenfeld GD
    Race, Ethnicity, and Sepsis: Beyond Adjusted Odds Ratios.
    Crit Care Med. 2018;46:1009-1010.
    PubMed     Text format    


  5. HENSLEY MK, Prescott HC
    Bad Brains, Bad Outcomes: Acute Neurologic Dysfunction and Late Death After Sepsis.
    Crit Care Med. 2018;46:1001-1002.
    PubMed     Text format    


    May 2018
  6. MCHALE TM, Garciarena CD, Fagan RP, Smith SGJ, et al
    Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis.
    Crit Care Med. 2018 May 18. doi: 10.1097/CCM.0000000000003219.
    PubMed     Text format     Abstract available


  7. LIMA A, van Rooij T, Ergin B, Sorelli M, et al
    Dynamic Contrast-Enhanced Ultrasound Identifies Microcirculatory Alterations in Sepsis-Induced Acute Kidney Injury.
    Crit Care Med. 2018 May 15. doi: 10.1097/CCM.0000000000003209.
    PubMed     Text format     Abstract available


  8. ESTENSSORO E, Kanoore Edul VS, Loudet CI, Osatnik J, et al
    Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina.
    Crit Care Med. 2018 May 8. doi: 10.1097/CCM.0000000000003208.
    PubMed     Text format     Abstract available


  9. MEARELLI F, Fiotti N, Giansante C, Casarsa C, et al
    Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study.
    Crit Care Med. 2018 May 7. doi: 10.1097/CCM.0000000000003206.
    PubMed     Text format     Abstract available


  10. ABU-KAF H, Mizrakli Y, Novack V, Dreiher J, et al
    Long-Term Survival of Young Patients Surviving ICU Admission With Severe Sepsis.
    Crit Care Med. 2018 May 7. doi: 10.1097/CCM.0000000000003205.
    PubMed     Text format     Abstract available


  11. LEWIS AJ, Zhang X, Griepentrog JE, Yuan D, et al
    Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis.
    Crit Care Med. 2018 May 4. doi: 10.1097/CCM.0000000000003190.
    PubMed     Text format     Abstract available


  12. KALIL AC, Van Schooneveld TC
    Is Procalcitonin-Guided Therapy Associated With Beneficial Outcomes in Critically Ill Patients With Sepsis?
    Crit Care Med. 2018;46:811-812.
    PubMed     Text format    


  13. STAUNTON O, Staunton C
    The Urgency of Now: Attacking the Sepsis Crisis.
    Crit Care Med. 2018;46:809-810.
    PubMed     Text format    


    April 2018
  14. MATHIEU C, Desrois M, Kober F, Lalevee N, et al
    Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study.
    Crit Care Med. 2018 Apr 7. doi: 10.1097/CCM.0000000000003146.
    PubMed     Text format     Abstract available


  15. MASSE MH, Richard MA, D'Aragon F, St-Arnaud C, et al
    Early Evidence of Sepsis-Associated Hyperperfusion-A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects.
    Crit Care Med. 2018 Apr 6. doi: 10.1097/CCM.0000000000003147.
    PubMed     Text format     Abstract available


  16. YOON J, Kym D, Hur J, Kim Y, et al
    Comparative Usefulness of Sepsis-3, Burn Sepsis, and Conventional Sepsis Criteria in Patients With Major Burns.
    Crit Care Med. 2018 Apr 3. doi: 10.1097/CCM.0000000000003144.
    PubMed     Text format     Abstract available


  17. CROUSER ED
    Sepsis-Induced Renal Failure: Ischemia or Toxemia?
    Crit Care Med. 2018;46:658-660.
    PubMed     Text format    


  18. KLOMPAS M, Rhee C
    Missed Opportunities for Better Sepsis Care or Misplaced Blame? Deconstructing Patients' Encounters in the Week Before Sepsis Hospitalizations.
    Crit Care Med. 2018;46:644-645.
    PubMed     Text format    


  19. NATHANSON BH
    First, Most, and Best: The Implications of Delays in Implementing Surviving Sepsis Campaign Guidelines.
    Crit Care Med. 2018;46:642-643.
    PubMed     Text format    


  20. SAVEL RH, Shiloh AL, Simon RJ, Kupfer Y, et al
    Using Big Data to See the Big Picture in Sepsis.
    Crit Care Med. 2018;46:640-641.
    PubMed     Text format    


    March 2018
  21. SKORUP P, Maudsdotter L, Tano E, Lipcsey M, et al
    Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model.
    Crit Care Med. 2018 Mar 27. doi: 10.1097/CCM.0000000000003139.
    PubMed     Text format     Abstract available


  22. SWEENEY TE, Azad TD, Donato M, Haynes WA, et al
    Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.
    Crit Care Med. 2018 Mar 13. doi: 10.1097/CCM.0000000000003084.
    PubMed     Text format     Abstract available


  23. LEE SH, Hsu TC, Lee MG, Chao CC, et al
    Nationwide Trend of Sepsis: A Comparison Among Octogenarians, Elderly, and Young Adults.
    Crit Care Med. 2018 Mar 10. doi: 10.1097/CCM.0000000000003085.
    PubMed     Text format     Abstract available


  24. SCHEER CS, Kuhn SO, Rehberg S
    Sepsis-3 Is a Positive Evolution in Discrimination Between Septic and Nonseptic Patients As Well As Sepsis Entities, Not a Step Backward.
    Crit Care Med. 2018;46:e273.
    PubMed     Text format    


  25. MACHADO FR, Azevedo LCP
    Sepsis: A Threat That Needs a Global Solution.
    Crit Care Med. 2018;46:454-459.
    PubMed     Text format    


  26. MEYER N, Harhay MO, Small DS, Prescott HC, et al
    Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis.
    Crit Care Med. 2018;46:354-360.
    PubMed     Text format     Abstract available


    February 2018
  27. ROSJO H, Masson S, Caironi P, Stridsberg M, et al
    Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.
    Crit Care Med. 2018 Feb 23. doi: 10.1097/CCM.0000000000003050.
    PubMed     Text format     Abstract available


  28. CHAUDHARY NS, Donnelly JP, Wang HE
    Racial Differences in Sepsis Mortality at U.S. Academic Medical Center-Affiliated Hospitals.
    Crit Care Med. 2018 Feb 12. doi: 10.1097/CCM.0000000000003020.
    PubMed     Text format     Abstract available


  29. SCHULER A, Wulf DA, Lu Y, Iwashyna TJ, et al
    The Impact of Acute Organ Dysfunction on Long-Term Survival in Sepsis.
    Crit Care Med. 2018 Feb 9. doi: 10.1097/CCM.0000000000003023.
    PubMed     Text format     Abstract available


  30. RYOO SM, Lee J, Lee YS, Lee JH, et al
    Lactate Level Versus Lactate Clearance for Predicting Mortality in Patients With Septic Shock Defined by Sepsis-3.
    Crit Care Med. 2018 Feb 9. doi: 10.1097/CCM.0000000000003030.
    PubMed     Text format     Abstract available


  31. PRESCOTT HC, Cope TM, Gesten FC, Ledneva TA, et al
    Reporting of Sepsis Cases for Performance Measurement Versus for Reimbursement in New York State.
    Crit Care Med. 2018 Feb 5. doi: 10.1097/CCM.0000000000003005.
    PubMed     Text format     Abstract available


  32. MORLEY PT
    Early Fluid Management in Sepsis: Yes.
    Crit Care Med. 2018;46:327-328.
    PubMed     Text format    


    January 2018
  33. LIN X, Luo H, Yan X, Song Z, et al
    Interleukin-34 Ameliorates Survival and Bacterial Clearance in Polymicrobial Sepsis.
    Crit Care Med. 2018 Jan 30. doi: 10.1097/CCM.0000000000003017.
    PubMed     Text format     Abstract available


  34. CHERRUAULT M, Le Goff M, Tamburini J, Pene F, et al
    Urgent Chemotherapy in Sepsis-Like Shock Related to Hematologic Malignancies.
    Crit Care Med. 2018 Jan 25. doi: 10.1097/CCM.0000000000002990.
    PubMed     Text format     Abstract available


  35. LYONS PG, Micek ST, Hampton N, Kollef MH, et al
    Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality.
    Crit Care Med. 2018 Jan 25. doi: 10.1097/CCM.0000000000002997.
    PubMed     Text format     Abstract available


  36. FAISAL M, Scally A, Richardson D, Beatson K, et al
    Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient's First Electronically Recorded Vital Signs and Blood Test Results.
    Crit Care Med. 2018 Jan 24. doi: 10.1097/CCM.0000000000002967.
    PubMed     Text format     Abstract available


  37. LEWIS AJ, Griepentrog JE, Zhang X, Angus DC, et al
    Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis: A Murine Trial.
    Crit Care Med. 2018 Jan 23. doi: 10.1097/CCM.0000000000003004.
    PubMed     Text format     Abstract available


  38. LIU VX, Escobar GJ, Chaudhary R, Prescott HC, et al
    Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization.
    Crit Care Med. 2018 Jan 5. doi: 10.1097/CCM.0000000000002960.
    PubMed     Text format     Abstract available


  39. KURODA K, Wake H, Mori S, Hinotsu S, et al
    Decrease in Histidine-Rich Glycoprotein as a Novel Biomarker to Predict Sepsis Among Systemic Inflammatory Response Syndrome.
    Crit Care Med. 2018 Jan 4. doi: 10.1097/CCM.0000000000002947.
    PubMed     Text format     Abstract available


  40. JOHNSON AEW, Aboab J, Raffa JD, Pollard TJ, et al
    A Comparative Analysis of Sepsis Identification Methods in an Electronic Database.
    Crit Care Med. 2018 Jan 4. doi: 10.1097/CCM.0000000000002965.
    PubMed     Text format     Abstract available


  41. PRUINELLI L, Westra BL, Yadav P, Hoff A, et al
    Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock.
    Crit Care Med. 2018 Jan 2. doi: 10.1097/CCM.0000000000002949.
    PubMed     Text format     Abstract available


  42. DOTSON B
    Calcium Channel Blockers and Sepsis Outcomes.
    Crit Care Med. 2018;46:e97-e98.
    PubMed     Text format    


  43. DELMAS B, Jabot J, Chanareille P, Ferdynus C, et al
    Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions.
    Crit Care Med. 2018;46:93-99.
    PubMed     Text format     Abstract available


  44. LANKADEVA YR, Kosaka J, Evans RG, Bellomo R, et al
    Urinary Oxygenation as a Surrogate Measure of Medullary Oxygenation During Angiotensin II Therapy in Septic Acute Kidney Injury.
    Crit Care Med. 2018;46:e41-e48.
    PubMed     Text format     Abstract available


  45. TYLER PD, Stone DJ, Geisler BP, McLennan S, et al
    Racial and Geographic Disparities in Interhospital ICU Transfers.
    Crit Care Med. 2018;46:e76-e80.
    PubMed     Text format     Abstract available


  46. MIANO TA, Lam S
    The Healthy User Effect in Studies of Statins in the Critically Ill.
    Crit Care Med. 2018;46:e95.
    PubMed     Text format    


    December 2017
  47. NEMATI S, Holder A, Razmi F, Stanley MD, et al
    An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU.
    Crit Care Med. 2017 Dec 26. doi: 10.1097/CCM.0000000000002936.
    PubMed     Text format     Abstract available


  48. IANKOVA I, Thompson-Leduc P, Kirson NY, Rice B, et al
    Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2017 Dec 21. doi: 10.1097/CCM.0000000000002928.
    PubMed     Text format     Abstract available


  49. SEMERARO F, Colucci M, Caironi P, Masson S, et al
    Platelet Drop and Fibrinolytic Shutdown in Patients With Sepsis.
    Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002919.
    PubMed     Text format     Abstract available


  50. ROBERTS BW, Mohr NM, Ablordeppey E, Drewry AM, et al
    Association Between Partial Pressure of Arterial Carbon Dioxide and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department.
    Crit Care Med. 2017 Dec 19. doi: 10.1097/CCM.0000000000002918.
    PubMed     Text format     Abstract available


  51. VALLEY TS, Nallamothu BK, Heung M, Iwashyna TJ, et al
    Hospital Variation in Renal Replacement Therapy for Sepsis in the United States.
    Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002878.
    PubMed     Text format     Abstract available


  52. PHILLIPS GS, Osborn TM, Terry KM, Gesten F, et al
    The New York Sepsis Severity Score: Development of a Risk-Adjusted Severity Model for Sepsis.
    Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002824.
    PubMed     Text format     Abstract available


  53. KIKUTANI K, Ohshimo S, Shime N
    Potential Confounders of Procalcitonin-Guided Antibiotic Therapy for Sepsis.
    Crit Care Med. 2017;45:e1310-e1311.
    PubMed     Text format    


  54. KRAMER AH
    Is A Hemoglobin Concentration As Low As 7 g/dL Adequate For All Critically Ill Patients With Sepsis? Legitimate Doubts Remain!
    Crit Care Med. 2017;45:2101-2102.
    PubMed     Text format    


  55. ERWIN BL, Denaburg MA, Barker AB, McArdle PJ, et al
    Evaluation of Vasopressin for Septic Shock in Patients on Chronic Renin-Angiotensin-Aldosterone System Inhibitors.
    Crit Care Med. 2017;45:e1226-e1232.
    PubMed     Text format     Abstract available


  56. DU W, Liu D, Long Y, Wang X, et al
    The beta-Blocker Esmolol Restores the Vascular Waterfall Phenomenon After Acute Endotoxemia.
    Crit Care Med. 2017;45:e1247-e1253.
    PubMed     Text format     Abstract available


  57. JAMME M, Daviaud F, Charpentier J, Marin N, et al
    Time Course of Septic Shock in Immunocompromised and Nonimmunocompromised Patients.
    Crit Care Med. 2017;45:2031-2039.
    PubMed     Text format     Abstract available


  58. DUPUIS C, Garrouste-Orgeas M, Bailly S, Adrie C, et al
    Effect of Transfusion on Mortality and Other Adverse Events Among Critically Ill Septic Patients: An Observational Study Using a Marginal Structural Cox Model.
    Crit Care Med. 2017;45:1972-1980.
    PubMed     Text format     Abstract available


    November 2017
  59. LEISMAN DE, Doerfler ME, Schneider SM, Masick KD, et al
    Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock.
    Crit Care Med. 2017 Nov 3. doi: 10.1097/CCM.0000000000002834.
    PubMed     Text format     Abstract available


  60. CASEY JD, Semler MW, Bastarache JA
    Aspirin for Sepsis Prophylaxis: An Ounce of Prevention?
    Crit Care Med. 2017;45:1959-1960.
    PubMed     Text format    


  61. JAWA RS, Kew RR
    Sepsis in the Critically Ill-Does Gender Matter?
    Crit Care Med. 2017;45:1957-1959.
    PubMed     Text format    


  62. SPOLARICS Z
    Victims or Culprits, B Cells May Serve as Markers for Mortality Risk and Targeted Therapy in Sepsis.
    Crit Care Med. 2017;45:1951-1952.
    PubMed     Text format    


  63. LIU VX, Walkey AJ
    Machine Learning and Sepsis: On the Road to Revolution.
    Crit Care Med. 2017;45:1946-1947.
    PubMed     Text format    


  64. COQUEREL D, Chagnon F, Sainsily X, Dumont L, et al
    ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.
    Crit Care Med. 2017;45:e1139-e1148.
    PubMed     Text format     Abstract available


  65. MOSKOWITZ A, Patel PV, Grossestreuer AV, Chase M, et al
    Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection.
    Crit Care Med. 2017;45:1813-1819.
    PubMed     Text format     Abstract available


    October 2017
  66. STEELAND S, Van Ryckeghem S, Vandewalle J, Ballegeer M, et al
    Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
    Crit Care Med. 2017 Oct 31. doi: 10.1097/CCM.0000000000002813.
    PubMed     Text format     Abstract available


  67. RUSH B, Tyler PD, Stone DJ, Geisler BP, et al
    Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis.
    Crit Care Med. 2017 Oct 24. doi: 10.1097/CCM.0000000000002777.
    PubMed     Text format     Abstract available


  68. YEHYA N, Wong HR
    Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002754.
    PubMed     Text format     Abstract available


  69. PUTHUCHEARY ZA, Sun Y, Zeng K, Vu LH, et al
    Sepsis Reduces Bone Strength Before Morphologic Changes Are Identifiable.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002732.
    PubMed     Text format     Abstract available


  70. WONG HR, Sweeney TE, Hart KW, Khatri P, et al
    Pediatric Sepsis Endotypes Among Adults With Sepsis.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002733.
    PubMed     Text format     Abstract available


  71. EHLENBACH WJ, Gilmore-Bykovskyi A, Repplinger MD, Westergaard RP, et al
    Sepsis Survivors Admitted to Skilled Nursing Facilities: Cognitive Impairment, Activities of Daily Living Dependence, and Survival.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002755.
    PubMed     Text format     Abstract available


  72. MEYER NJ, Reilly JP, Anderson BJ, Palakshappa JA, et al
    Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration.
    Crit Care Med. 2017 Oct 6. doi: 10.1097/CCM.0000000000002749.
    PubMed     Text format     Abstract available


  73. VITORIO D, Nassar AP Jr, Caruso P
    Procalcitonin Clearance and Prognosis in Sepsis: Are There Really an Optimal Cutoff and Time Interval?
    Crit Care Med. 2017;45:e1097-e1098.
    PubMed     Text format    


  74. PFORTMUELLER CA, Meisel C, Schefold JC
    Interpreting Immune Mediator Dysbalance in Sepsis.
    Crit Care Med. 2017;45:e1094-e1095.
    PubMed     Text format    


  75. RIMAWI RH
    Bad Response or Bad Luck? A New Versus Recrudescent Sepsis Readmission.
    Crit Care Med. 2017;45:1788-1789.
    PubMed     Text format    


  76. LANSPA MJ, Morris AH
    The Importance of Clinical Context on Assessing Outcomes in Sepsis.
    Crit Care Med. 2017;45:1783-1785.
    PubMed     Text format    


  77. NUGENT KL, Coopersmith CM
    Fluid Management in Sepsis-Is There a Golden Hour (or Two)?
    Crit Care Med. 2017;45:1773-1775.
    PubMed     Text format    


  78. GRASSELLI G, Scaravilli V, Di Bella S, Biffi S, et al
    Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impact on Patients' Outcome.
    Crit Care Med. 2017;45:1726-1733.
    PubMed     Text format     Abstract available


    September 2017
  79. ANNANE D, Pastores SM, Rochwerg B, Arlt W, et al
    Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.
    Crit Care Med. 2017 Sep 21. doi: 10.1097/CCM.0000000000002737.
    PubMed     Text format     Abstract available


  80. JONES JM, Fingar KR, Miller MA, Coffey R, et al
    Racial Disparities in Sepsis-Related In-Hospital Mortality: Using a Broad Case Capture Method and Multivariate Controls for Clinical and Hospital Variables, 2004-2013.
    Crit Care Med. 2017 Sep 12. doi: 10.1097/CCM.0000000000002699.
    PubMed     Text format     Abstract available


  81. WANG HE, Jones AR, Donnelly JP
    Revised National Estimates of Emergency Department Visits for Sepsis in the United States.
    Crit Care Med. 2017;45:1443-1449.
    PubMed     Text format     Abstract available


  82. AGAROSSI A, Pintaudi G
    Antimicrobials and Progression to Septic Shock in Severe Sepsis Patients: Is Delay the Only Thing That Matters?
    Crit Care Med. 2017;45:e988-e989.
    PubMed     Text format    


  83. MARSHALL JC
    Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis.
    Crit Care Med. 2017;45:1582-1583.
    PubMed     Text format    


  84. GAUDILLIERE B, Angst MS, Hotchkiss RS
    Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!
    Crit Care Med. 2017;45:1577-1578.
    PubMed     Text format    


  85. RHEE C, Klompas M
    What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition.
    Crit Care Med. 2017;45:1569-1571.
    PubMed     Text format    


  86. DEUTSCHMAN CS
    Sepsis-3: Seeing the Entire Picture.
    Crit Care Med. 2017;45:1567-1569.
    PubMed     Text format    


  87. SPRUNG CL, Trahtemberg U
    What Definition Should We Use for Sepsis and Septic Shock?
    Crit Care Med. 2017;45:1564-1567.
    PubMed     Text format    


  88. FADEL F, Andre-Gregoire G, Gravez B, Bauvois B, et al
    Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock.
    Crit Care Med. 2017;45:e954-e962.
    PubMed     Text format     Abstract available


    August 2017
  89. VAN VUGHT LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, et al
    Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.
    Crit Care Med. 2017 Aug 11. doi: 10.1097/CCM.0000000000002649.
    PubMed     Text format     Abstract available


  90. ZHAI Q, Lai D, Cui P, Zhou R, et al
    Selective Activation of Basal Forebrain Cholinergic Neurons Attenuates Polymicrobial Sepsis-Induced Inflammation via the Cholinergic Anti-Inflammatory Pathway.
    Crit Care Med. 2017 Aug 10. doi: 10.1097/CCM.0000000000002646.
    PubMed     Text format     Abstract available


  91. TRAUER J, Muhi S, McBryde ES, Al Harbi SA, et al
    Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.
    Crit Care Med. 2017 Aug 9. doi: 10.1097/CCM.0000000000002654.
    PubMed     Text format     Abstract available


  92. KALIL AC, Kellum JA
    Is Early Goal-Directed Therapy Harmful to Patients With Sepsis and High Disease Severity?
    Crit Care Med. 2017;45:1265-1267.
    PubMed     Text format    


    July 2017
  93. SHANKAR-HARI M, Singer M, Spencer J
    Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?
    Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002627.
    PubMed     Text format     Abstract available


  94. DEMERLE KM, Royer SC, Mikkelsen ME, Prescott HC, et al
    Readmissions for Recurrent Sepsis: New or Relapsed Infection?
    Crit Care Med. 2017 Jul 22. doi: 10.1097/CCM.0000000000002626.
    PubMed     Text format     Abstract available


  95. VAN VUGHT LA, Holman R, de Jonge E, de Keizer NF, et al
    Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis.
    Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002590.
    PubMed     Text format     Abstract available


  96. CHURPEK MM, Snyder A, Sokol S, Pettit NN, et al
    Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores.
    Crit Care Med. 2017 Jul 21. doi: 10.1097/CCM.0000000000002648.
    PubMed     Text format     Abstract available


  97. MACHADO FR, Ferreira EM, Sousa JL, Silva C, et al
    Quality Improvement Initiatives in Sepsis in an Emerging Country: Does the Institution's Main Source of Income Influence the Results? An Analysis of 21,103 Patients.
    Crit Care Med. 2017 Jul 6. doi: 10.1097/CCM.0000000000002585.
    PubMed     Text format     Abstract available


  98. NI CHEALLAIGH C, Sheedy FJ
    Shields Up-Systemic Protection Provided by microRNA-21 During Sepsis?
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  99. MARRARO GA, Genovese U, Spada C, Piga MA, et al
    Can the Treatment Approach of Sepsis With Balanced Crystalloid Fluids Translate Into Therapy for Acute Respiratory Distress Syndrome if Considered as "Lung-Limited Sepsis"?
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  100. PRESCOTT HC, Donnelly JP
    Penalizing Readmissions After Sepsis Could Do More Harm Than Good.
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    June 2017
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    Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort.
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  102. LEE CC, Lee MG, Lee WC, Lai CC, et al
    Preadmission Use of Calcium Channel Blocking Agents Is Associated With Improved Outcomes in Patients With Sepsis: A Population-Based Propensity Score-Matched Cohort Study.
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  103. HE X, Su F, Xie K, Taccone FS, et al
    Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis.
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  104. LEISMAN DE, Sethna CB
    Renin-Angiotensin-Aldosterone System Blockade Use in Sepsis Patients: Did It Impact Renal Outcomes?
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  105. GAINES S, Alverdy JC
    Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.
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  106. FRAIMOW HS
    Safe at First, But Not Reaching Second: Implications of Delayed Second Doses of Antimicrobials in Patients Presenting to Emergency Departments With Sepsis.
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  107. DAVIS AL, Carcillo JA, Aneja RK, Deymann AJ, et al
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  108. PELTAN ID, Mitchell KH, Rudd KE, Mann BA, et al
    Physician Variation in Time to Antimicrobial Treatment for Septic Patients Presenting to the Emergency Department.
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  109. HENNING DJ, Carey JR, Oedorf K, Day DE, et al
    The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock.
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  110. RUSSELL JA, Lee T, Singer J, Boyd JH, et al
    The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.
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  111. TERRASINI N, Lionetti V
    Exosomes in Critical Illness.
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    May 2017
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    The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
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  113. STANA F, Vujovic M, Mayaki D, Leduc-Gaudet JP, et al
    Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.
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  114. DEUTSCHMAN CS
    "Defining" Sepsis: Moving Toward Measuring the "Dysregulated Host Response".
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  115. MARIK PE
    Glucocorticosteroids as Adjunctive Therapy for Acute Respiratory Distress Syndrome and Sepsis? Yes, But Not as Monotherapy.
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  116. LEVY MM
    Antibiotics in Sepsis: The New Frontier.
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  117. JUNG B, Mahul M, Breilh D, Legeron R, et al
    Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under- and Overdosing.
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  118. BERGAMIN FS, Almeida JP, Landoni G, Galas FRBG, et al
    Liberal Versus Restrictive Transfusion Strategy in Critically Ill Oncologic Patients: The Transfusion Requirements in Critically Ill Oncologic Patients Randomized Controlled Trial.
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  119. DREWRY AM, Ablordeppey EA, Murray ET, Stoll CRT, et al
    Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis.
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    Sepsis-Associated 30-Day Risk-Standardized Readmissions: Analysis of a Nationwide Medicare Sample.
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    Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis.
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    MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis.
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  124. ARULKUMARAN N, Sixma ML, Jentho E, Ceravola E, et al
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    Population-Based Epidemiology of Sepsis in a Subdistrict of Beijing.
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  126. PINTO BB, Dyson A, Umbrello M, Carre JE, et al
    Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand.
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  127. SCICLUNA BP, van der Poll T
    Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.
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  128. WALLEY KR
    New Approaches to Modifying Inotropy in Sepsis-Induced Myocardial Dysfunction.
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  129. SIMPSON SQ
    Surviving Transfer for Sepsis: Size Matters-Or Does It?
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  130. LAUPLAND KB, Niven DJ
    The Normal Abnormal Vital Sign of Sepsis.
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  131. DEUTSCHMAN CS
    Sepsis-3: Of Love and Bliss.
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  132. ALDER MN, Opoka AM, Lahni P, Hildeman DA, et al
    Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.
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    Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis.
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    March 2017
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    Association Between Hospital Case Volume of Sepsis, Adherence to Evidence-Based Processes of Care and Patient Outcomes.
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  138. MCKOWN AC, McGuinn EM, Ware LB, Wang L, et al
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  139. SCHUETZ P, Birkhahn R, Sherwin R, Jones AE, et al
    Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
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  141. PEPPER DJ
    Adipose Tissue Measurements in Patients With Sepsis.
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  142. KUHN SO, Meissner K, Rehberg S
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  143. MOROWITZ MJ, Di Caro V, Pang D, Cummings J, et al
    Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.
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    Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study.
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  148. WHILES BB, Deis AS, Simpson SQ
    Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients.
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  149. BRENT AJ
    Meta-Analysis of Time to Antimicrobial Therapy in Sepsis: Confounding as Well as Bias.
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  150. BRIASSOULIS G, Ilia S
    Vitamin D Deficiency in Sepsis: "Body Humors" Imbalance or Sepsis "Epiphenomenon"?
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  151. BHARDWAJ A, Mikkelsen ME
    Sepsis Quality Improvement Initiatives: Prepare for the Marathon, Not the Sprint.
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  152. ALVERDY JC, Krezalek MA
    Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.
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  158. COZ YATACO A, Jaehne AK, Rivers EP
    Protocolized Early Sepsis Care Is Not Only Helpful for Patients: It Prevents Medical Errors.
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  163. CROUSER ED, Hotchkiss RS
    Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.
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  164. RIE M
    Rural Sepsis Mortality: Patient Emergency Care Preference Impacts Resuscitation Outcome Value.
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    Source Control in Sepsis Urgent or Not So Fast?
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    1457: THE RELATIONSHIP BETWEEN BLOOD PRESSURE VARIABILITY AND LACTATE IN EARLY SEPSIS RESUSCITATION.
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  198. GUIRGIS F, Sterling S, Smotherman C, Moore F, et al
    1456: A COMPARISON OF SOFA USING SPO2/FIO2 RATIO TO SOFA, SIRS, AND QSOFA FOR SEPSIS MORTALITY.
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  199. YUNE H, Kim K, Jo YH, Kim J, et al
    1453: INFUSION OF METHYLENE BLUE IN SEVERE SEPSIS AND SEPTIC SHOCK: A RANDOMIZED CONTROLLED TRIAL.
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  200. JAIMES F, Londono J, Nino C, Valencia M, et al
    1452: NO IMPROVEMENT WITH EGDT OR ANTIBIOTICS IN PATIENTS WITH SEPSIS: AN INSTRUMENTAL VARIABLE ANALYSIS.
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  201. HARTOG C, Matt B, Kortgen A, Konig C, et al
    1446: WHAT MATTERS MOST TO SURVIVORS OF SEPSIS? DEVELOPMENT OF PATIENT-REPORTED QUALITY-OF-LIFE DOMAINS.
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  202. SAKHUJA A, Kumar G, Vallabhajosyula S, Kashyap R, et al
    1445: WHO CAN BE CALLED "ELDERLY" FOR SEVERE SEPSIS MORTALITY?
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  203. LEVY E, Zinter M, Madden K, Randolph A, et al
    1444: MANNOSE-BINDING LECTIN AND PEDIATRIC SEPSIS SUSCEPTIBILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS.
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  204. HANDY B, Jones P, Ostlund R Jr, Schuetz P, et al
    1440: VALIDATION OF THE ELECSYS BRAHMS PROCALCITONIN ASSAY IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK.
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  205. MILZMAN D, Paik M, Shuster K, Floyd R, et al
    1438: EARLY DETERMINATION OF OUTCOMES FOR SIRS VS QSOFA IN ED SEPSIS PATIENTS.
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  206. WALKER J, Peters M, Nadel S, Pathan N, et al
    1436: THE ABILITY OF SEPSIS CRITERIA TO PREDICT SERIOUS BACTERIAL INFECTION IN CRITICALLY ILL CHILDREN.
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  207. MORESCO B, Root K, Cuellar C, Harkins L, et al
    1435: EVALUATION OF EARLY MANAGEMENT OF SEPSIS AND COMPLIANCE WITH SEPSIS GUIDELINES.
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  208. WISKAR K, Boyd J, Rush B
    1434: ASSOCIATION BETWEEN HOSPITAL CHARACTERISTICS AND MORTALITY IN SEPSIS.
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  209. TAYLOR S, Gandy T, Karvestski C, Templin M, et al
    1428: INCIDENCE, PREDICTORS, AND ALTERNATE DIAGNOSES OF PATIENTS WITH FALSE-POSITIVE SEVERE SEPSIS.
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  210. FERREIRA J, Adams C, Tucker C, Allen B, et al
    1427: EFFICACY OF NON-WEIGHT-BASED VASOPRESSOR DOSING IN CRITICALLY ILL PATIENTS WITH SEVERE SEPSIS.
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  211. LEISMAN D, D'Amore J, Gribben J, Ward M, et al
    1426: BUNDLE COMPLIANCE EFFECT GREATER IN HEMODYNAMICALLY STABLE SEPSIS PATIENTS WITH INTERMEDIATE LACTATE.
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  212. SPECTOR R, Blau S
    1425: SEPSIS MANAGEMENT: THE EFFECT OF PROTOCOL INITIATION ON PATIENT OUTCOME.
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  213. PARK JR, Kim Y, Park T, Oh WY, et al
    1423: MICROCIRCULATORY ALTERATIONS IN HEMORRHAGIC SHOCK AND SEPSIS WITH OPTICAL COHERENCE TOMOGRAPHY.
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  214. PEARSON D, Benson A, Blanset J, Lovett K, et al
    1422: COMMON REASONS CORE MEASURES ARE NOT MET IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK.
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  215. PELTAN I, Mitchell K, Rudd K, Mann B, et al
    1421: PREHOSPITAL LEVEL OF CARE, PREHOSPITAL IV ACCESS, AND TIMING OF ANTIBIOTICS IN SEPSIS.
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  216. IBARRA F, Rowden A, Dzintars K, Lindsley J, et al
    1418: UTILITY OF A SEVERE SEPSIS ORDER SET IN A MEDICAL INTENSIVE CARE UNIT.
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  217. WOZNIAK J, Dargin J
    1416: THE EFFECT OF PROVIDING CLINICAL PERFORMANCE FEEDBACK ON COMPLIANCE WITH SEPSIS TREATMENT BUNDLES.
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  218. WOZNIAK J, Dargin J
    1415: THE EFFECT OF PROVIDING CLINICAL PERFORMANCE FEEDBACK ON COMPLIANCE WITH SEPSIS TREATMENT BUNDLES.
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  219. HUANG C, Daniels R, Lembo A, Heymann T, et al
    1413: MENTAL, PHYSIOLOGIC, AND FUNCTIONAL DISABILITIES IN POST-SEPSIS SYNDROME: AN INTERNATIONAL SURVEY.
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  220. NGUYEN T, Marini J, Lam F, Cohen D, et al
    1411: PORCINE MODEL OF STAPHYLOCOCCUS AUREUS SEPSIS-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION.
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  221. STEGER A, Pedersen A, Shears E, Hurst L, et al
    1409: A NURSE-LED APPROACH TO IMPROVE EARLY SEPSIS CARE IN THE EMERGENCY DEPARTMENT.
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  222. SHAH T, Rech M, Sterk E
    1406: IMPACT OF THE EMERGENCY DEPARTMENT SEPSIS SCREENING TOOL ON OUTCOMES IN PATIENTS WITH SEPSIS.
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  223. SAKHUJA A, Kumar G, Vallabhajosyula S, Kashani K, et al
    1405: SEASONAL VARIATIONS IN SEVERE SEPSIS HOSPITALIZATIONS.
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  224. TAYLOR S, Roohollahi A, Karvetski C, Templin M, et al
    1403: DOES CIRRHOSIS AFFECT THE PROGNOSTIC UTILITY OF LACTATE FOR SEVERE SEPSIS?
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  225. ATEELI H, Jaffer F, Goel K, Low SW, et al
    1402: CURB-65 SCORE CORRELATES WITH ICU ADMISSION AND IN-HOSPITAL MORTALITY IN PATIENTS WITH SEPSIS.
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  226. CUSTER J, Bhutta A, Bagdure D, Holloway A, et al
    1399: OUTCOMES OF PEDIATRIC PATIENTS WITH SEPSIS MANAGED ON EXTRACORPOREAL MEMBRANE OXYGENATION.
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  227. HOSHINO K, Kawano Y, Maruyama J, Mizunuma M, et al
    1398: PLASMINOGEN ACTIVATOR INHIBITOR-1 IS THE MOST PREDICTIVE MARKER OF MORTALITY IN SEPSIS.
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  228. HUANG C, Daniels R, Lembo A, Heymann T, et al
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  229. LEISMAN D, Huang V, Zhou Q, Gribben J, et al
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  230. TANNEHILL D, O'Brien J, Kasal J, Subramanian S, et al
    1395: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS AND SEPTIC SHOCK PATIENTS.
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  231. MCHUGH W, McDonough K, Carlton E, Kidwell K, et al
    1394: PERSONALIZED IMMUNOMODULATION IN HIGH-RISK SEPSIS PATIENTS IN A PEDIATRIC CRITICAL CARE UNIT.
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  233. FUKUDA S, Randolph A, Ihara K, Cox R, et al
    1390: PEROXYNITRITE DECOMPOSITION CATALYST REDUCES NOREPINEPHRINE REQUIREMENT DURING SEPSIS IN OVINE MODEL.
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  234. MOORE C, Ainsworth J, Wang Y, Barnes L, et al
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  235. RUSH B, Wiskar K, Boyd J
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    1387: FLECAINIDE ATTENUATES SEPSIS-INDUCED ACUTE LUNG INJURY BY CONTROLLING INFLAMMATORY RESPONSE.
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    1384: SUCCESS WITH IMPLEMENTATION OF A SYSTEM-BASED SEPSIS MANAGEMENT PROGRAM.
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  240. AAKRE C, Kitson J, Herasevich V
    1380: TIME-MOTION ANALYSIS AND ECONOMIC IMPACT OF SOFA SCORE INTEGRATION INTO THE NEW SEPSIS-3 DEFINITION.
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    1376: THE EFFECT OF EMERGENCY ROOM FLUID RESUSCITATION ON PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK.
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    1370: VOLUME ADMINISTRATION AND OUTCOMES IN OBESE PATIENTS WITH SEPSIS IN THE ERA OF PROTOCOLIZED CARE.
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  249. LI X, Guo L, Yuan Y, Zhan CG, et al
    1368: SYNTHETIC HDL AS AN EFFECTIVE THERAPY FOR SEPSIS.
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    1366: CLINICAL IMPLICATIONS OF THE PLASMA EPHA2 RECEPTOR LEVEL IN PATIENTS WITH SEPSIS.
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  251. TANNEHILL D, Sharpe B, Miller M, Saifo A, et al
    1365: SEPSIS-3 APPLIED TO A HISTORICAL COHORT OF SEVERE SEPSIS PATIENTS TREATED OUTSIDE THE ICU.
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  252. GASPERINO J, Gabriel-Jocson E, Perez E, Levy R, et al
    1364: COMPARISON OF THE QSOFA SCORE AND SIRS CRITERIA IN PATIENTS WITH KNOWN OR SUSPECTED SEPSIS.
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  253. ZHAI X, Jiang L, Yang Z, Yu T, et al
    1363: EFFECT OF ULINASTATIN ON MICROCIRCULATION DURING SEPSIS IN A RAT CECAL LIGATION AND PUNCTURE MODEL.
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  254. VALLABHAJOSYULA S, Jentzer J, Geske J, Kashani K, et al
    1362: LONG-TERM NEW-ONSET HEART FAILURE IN PATIENTS WITH MYOCARDIAL DYSFUNCTION IN SEPSIS AND SEPTIC SHOCK.
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  255. WALSH M, Hobbs B, Giancarelli A, Bhullar I, et al
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    1354: AN AGGRESSIVE SEPSIS IDENTIFICATION INITIATIVE INCREASES FALSE-POSITIVE DIAGNOSES.
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    1352: IMPACT OF MITOCHONDRIAL ROS SCAVENGERS ON CARDIAC MECHANICS IN A MURINE MODEL OF SEPSIS.
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    1347: USEFULNESS OF SEPSIS BIOMARKERS ACCORDING TO THE NEW DEFINITIONS OF SEPSIS.
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    1344: PLASMA RIP3, A REGULATOR OF NECROPTOSIS, IS ASSOCIATED WITH MORTALITY & ORGAN DYSFUNCTION IN SEPSIS.
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    1342: INTERHOSPITAL TRANSFER OF PATIENTS WITH SEPSIS ACROSS THE UNITED STATES.
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  293. HIRANO Y, Aziz M, Weng-Lang Y, Ochani M, et al
    21: THE ROLE OF JUNCTIONAL ADHESION MOLECULE C IN THE AGING PHENOTYPE OF NEUTROPHILS DURING SEPSIS.
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  294. JOHNSON A, Celi LA, Raffa J, Pollard T, et al
    18: EXTERNAL VALIDATION OF THE SEPSIS-3 GUIDELINES.
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  295. ENKHBAATAR P
    Cellular Therapy for Sepsis: A New Hope?
    Crit Care Med. 2016;44:2296-2298.
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  296. KEMPKER JA, Martin GS
    Does Sepsis Case Mix Heterogeneity Prevent Outcome Comparisons?
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  297. TOWNSEND SR
    Collaborating for Success in Sepsis Quality Improvement.
    Crit Care Med. 2016;44:2275-2277.
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    November 2016
  298. ZHANG Z, Li Q
    Identifying Sepsis in Clinical Database With Sepsis-3 Definition.
    Crit Care Med. 2016;44:e1145-e1146.
    PubMed     Text format    


  299. ZIMMERMAN JJ, Davis R
    Imprecise (Sepsis) Medicine Can Become Precise.
    Crit Care Med. 2016;44:e1143-e1144.
    PubMed     Text format    


  300. SAVEL RH, Simon RJ, Kupfer Y
    Unraveling the Mysterious Relationship Between Obesity and Outcomes in Patients With Sepsis.
    Crit Care Med. 2016;44:2104-2105.
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  301. COHEN M, Falcone P, Kusnezov D, Paragas J, et al
    Sepsis and Presidential Initiatives.
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    October 2016
  302. JAEHNE AK, Rivers EP
    Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly.
    Crit Care Med. 2016.
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  303. YOUKEE D, Hulme W, Roberts T, Daniels R, et al
    Time Matters: Antibiotic Timing in Sepsis and Septic Shock.
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  304. SHIRAKURA Y, Kuriyama A
    Timing of Antibiotic Administration in Sepsis and Septic Shock: The Impact That a Meta-Analysis Does Not Depict.
    Crit Care Med. 2016;44:e1004.
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  305. MARRARO GA, Genovese U
    The Treatment of Severe Sepsis in the Pediatric Age: Long-Awaited Prospects and New Challenges Are Looming.
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    September 2016
  306. PREAU S, Bortolotti P, Colling D, Dewavrin F, et al
    Diagnostic Accuracy of the Inferior Vena Cava Collapsibility to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis and Acute Circulatory Failure.
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  307. SWEENEY TE, Khatri P
    Benchmarking Sepsis Gene Expression Diagnostics Using Public Data.
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  308. SCHEER CS, Fuchs C, Kuhn SO, Vollmer M, et al
    Quality Improvement Initiative for Severe Sepsis and Septic Shock Reduces 90-Day Mortality: A 7.5-Year Observational Study.
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  309. ZIMMERMAN JJ, Sullivan E, Yager TD, Cheng C, et al
    Diagnostic Accuracy of a Host Gene Expression Signature That Discriminates Clinical Severe Sepsis Syndrome and Infection-Negative Systemic Inflammation Among Critically Ill Children.
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  310. SEPULVEDA M, Gonano LA, Viotti M, Morell M, et al
    Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis.
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  311. MIRA JC, Gentile LF, Mathias BJ, Efron PA, et al
    Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
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  312. DALLI J, Colas RA, Quintana C, Barragan-Bradford D, et al
    Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.
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  313. MELLA JR, Chiswick E, Stepien D, Moitra R, et al
    Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.
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  314. PAREKH D, Patel JM, Scott A, Lax S, et al
    Vitamin D Deficiency in Human and Murine Sepsis.
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  315. AARVOLD AB, Ryan HM, Magee LA, von Dadelszen P, et al
    Multiple Organ Dysfunction Score Is Superior to the Obstetric-Specific Sepsis in Obstetrics Score in Predicting Mortality in Septic Obstetric Patients.
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  316. OAMI T, Watanabe E, Hatano M, Sunahara S, et al
    Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model.
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  317. BEESLEY SJ, Wilson EL, Lanspa MJ, Grissom CK, et al
    Relative Bradycardia in Patients With Septic Shock Requiring Vasopressor Therapy.
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  318. MOHR NM, Harland KK, Shane DM, Ahmed A, et al
    Rural Patients With Severe Sepsis or Septic Shock who Bypass Rural Hospitals Have Increased Mortality: An Instrumental Variables Approach.
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  319. MARTINEZ ML, Ferrer R, Torrents E, Guillamat-Prats R, et al
    Impact of Source Control in Patients With Severe Sepsis and Septic Shock.
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  320. BUNGER R, Mallet RT
    Metabolomics and Receiver Operating Characteristic Analysis: A Promising Approach for Sepsis Diagnosis.
    Crit Care Med. 2016;44:1784-5.
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    August 2016
  321. LI X, Kondo Y, Bao Y, Staudenmaier L, et al
    Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis.
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  322. TSOYI K, Hall SR, Dalli J, Colas RA, et al
    Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.
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  323. FITZGERALD JC, Basu RK, Akcan-Arikan A, Izquierdo LM, et al
    Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability.
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  324. WONG HR, Cvijanovich NZ, Anas N, Allen GL, et al
    Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype.
    Crit Care Med. 2016.
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  325. DELANEY A
    Protocolized Sepsis Care Is Not Helpful for Patients.
    Crit Care Med. 2016.
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  326. SAVAS G, Kalay N
    beta-Blocker Therapy Could Inflate the Diagnosis of Severe Sepsis.
    Crit Care Med. 2016;44:e765-6.
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  327. HAYES AJ, Mole DJ
    Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibition During Sepsis Dampens the Early Systemic Inflammatory Response.
    Crit Care Med. 2016;44:1628-9.
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  328. CROUSER ED
    Sepsis-Induced Endoplasmic Reticulum Stress: A Matter of Life and Death?
    Crit Care Med. 2016;44:1626-7.
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  329. HALBACH J, Bickler S, De Maio A
    The Molecular Complexity of Sepsis: Expression of Peroxisome Proliferator-Activated Receptor-alpha, the Tip of the Iceberg?
    Crit Care Med. 2016;44:1617-8.
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  330. ANDERSON-SHAW L
    Surviving Severe Sepsis: Is That Enough?
    Crit Care Med. 2016;44:1603-4.
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  331. MARSHALL JC
    Sepsis-3: What is the Meaning of a Definition?
    Crit Care Med. 2016;44:1459-60.
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    July 2016
  332. THOMPSON MP, Reeves MJ, Bogan BL, DiGiovine B, et al
    Protocol-Based Resuscitation Bundle to Improve Outcomes in Septic Shock Patients: Evaluation of the Michigan Health and Hospital Association Keystone Sepsis Collaborative.
    Crit Care Med. 2016.
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  333. LINDNER HA, Balaban U, Sturm T, Wei C, et al
    An Algorithm for Systemic Inflammatory Response Syndrome Criteria-Based Prediction of Sepsis in a Polytrauma Cohort.
    Crit Care Med. 2016.
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  334. GALLAGHER J, Killian AJ, Coopersmith CM
    Is A Diagnosis of Sepsis Sufficient to Warrant Stress Ulcer Prophylaxis?
    Crit Care Med. 2016;44:1450-1452.
    PubMed     Text format    


  335. KLOMPAS M, Rhee C
    We Need Better Tools for Sepsis Surveillance.
    Crit Care Med. 2016;44:1441-1442.
    PubMed     Text format    


  336. KEMPKER JA, Martin GS
    Sepsis to the Fore: Taking the Lead in Critical Care Admissions.
    Crit Care Med. 2016;44:1435-1436.
    PubMed     Text format    


  337. REILLY JP
    Predicting and Eventually Preventing the Future: Sepsis Risk in Community-Dwelling Adults.
    Crit Care Med. 2016;44:1425-1426.
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    June 2016
  338. HONORE PM, Nguyen HB, Gong M, Chawla LS, et al
    Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis.
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  339. SHANKAR-HARI M, Harrison DA, Rowan KM
    Differences in Impact of Definitional Elements on Mortality Precludes International Comparisons of Sepsis Epidemiology-A Cohort Study Illustrating the Need for Standardized Reporting.
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  340. KISSOON N, Daniels R, van der Poll T, Finfer S, et al
    Sepsis-The Final Common Pathway to Death From Multiple Organ Failure in Infection.
    Crit Care Med. 2016;44:e446.
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  341. SEELY AJ
    Treating Sepsis: Nearest Neighbors and Predicting Beginnings.
    Crit Care Med. 2016;44:1261-2.
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  342. CHEN J, Thiemermann C
    Selenium and Niacin for Sepsis Therapy: The Sum Is Greater Than Its Parts.
    Crit Care Med. 2016;44:1256-7.
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  343. GALVAGNO SM JR
    Outcomes Following Sepsis and Cardiopulmonary Resuscitation: Fare Thee Well or Worse for Wear?
    Crit Care Med. 2016;44:1232-3.
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  344. MARIK PE
    "Vitamin S" (Steroids) and Vitamin C for the Treatment of Severe Sepsis and Septic Shock!
    Crit Care Med. 2016;44:1228-9.
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    May 2016
  345. MOORMAN JR, Lake DE, Ivanov PC
    Early Detection of Sepsis-A Role for Network Physiology?
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  346. GUENANCIA C, Laurent G, Bruyere R, Quenot JP, et al
    New-Onset Atrial Fibrillation in Sepsis: So Common, but So Different.
    Crit Care Med. 2016;44:e306-e307.
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  347. WARD PA
    In Sepsis, Complement Is Alive and Well.
    Crit Care Med. 2016;44:1026-1027.
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  348. DEUTSCHMAN CS
    Imprecise Medicine: The Limitations of Sepsis-3.
    Crit Care Med. 2016;44:857-858.
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  349. VINCENT JL, Sampath R
    The authors reply.
    Crit Care Med. 2016;44:e315.
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  350. MITTAL S, Mohan A, Guleria R, Agarwal R, et al
    Rapid Diagnosis of Infection in Critically Ill: Is Molecular Diagnosis the Magic Bullet?
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  351. CONTENTI J, Levraut J
    The authors reply.
    Crit Care Med. 2016;44:e311-2.
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  352. BOULAIN T, Ehrmann S, Lakhal K
    beta-Blockade and Septic Shock Phenotype.
    Crit Care Med. 2016;44:e310-1.
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  353. CORDEIRO VENTURA A, Bousso A
    The authors reply.
    Crit Care Med. 2016;44:e310.
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  354. KLEIBER N, Tromp K, Tibboel D, de Wildt SN, et al
    Trial Recruitment in the Pediatric Intensive Care: Ask Consent Before You Start?!
    Crit Care Med. 2016;44:e309-e310.
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  355. CORDEIRO VENTURA A
    The author replies.
    Crit Care Med. 2016;44:e308-9.
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  356. SLAIN KN, Shein SL, Rotta AT
    The Dose Makes the Poison: Comparing Epinephrine With Dopamine in Pediatric Septic Shock.
    Crit Care Med. 2016;44:e308.
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    April 2016
  357. SHEN HN, Lu CL, Yang HH
    Risk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study.
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  358. MOORE JX, Donnelly JP, Griffin R, Howard G, et al
    Defining Sepsis Mortality Clusters in the United States.
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  359. NEUGEBAUER S, Giamarellos-Bourboulis EJ, Pelekanou A, Marioli A, et al
    Metabolite Profiles in Sepsis: Developing Prognostic Tools Based on the Type of Infection.
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  360. SASSOON CS, Zhu E, Fang L, Subramanian VS, et al
    Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis.
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  361. GENGA K, Russell JA
    Early Liberal Fluids for Sepsis Patients Are Harmful.
    Crit Care Med. 2016.
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  362. ALAM N, Nanayakkara PW
    Time for a Randomized Controlled Trial to Investigate Optimal Time to Antibiotics for Patients With Sepsis.
    Crit Care Med. 2016;44:e236-7.
    PubMed     Text format    


  363. KUMAR A
    Systematic Bias in Meta-Analyses of Time to Antimicrobial in Sepsis Studies.
    Crit Care Med. 2016;44:e234-5.
    PubMed     Text format    


  364. DONG JZ, Wang LP, Zhu JH
    Appropriate Antibiotic Therapy and WBC in Sepsis: Factors to Consider.
    Crit Care Med. 2016;44:e231.
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  365. SCHEER C, Fuchs C, Rehberg S
    Biomarkers in Severe Sepsis and Septic Shock: Just Listen to the Heart?
    Crit Care Med. 2016;44:849-50.
    PubMed     Text format    


  366. GELOEN A, Quintin L
    Reverse Physiology, i.e., Cellular Versus Integrative Versus Comparative Physiology? alpha-2 Agonists and Septic Shock.
    Crit Care Med. 2016;44:e238-9.
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  367. STERLING SA, Puskarich MA, Jones AE
    The authors reply.
    Crit Care Med. 2016;44:e237.
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  368. STERLING SA, Puskarich MA, Jones AE
    The authors reply.
    Crit Care Med. 2016;44:e235-6.
    PubMed     Text format    


  369. VENTURA AC, Goes PF
    The authors reply.
    Crit Care Med. 2016;44:e233-4.
    PubMed     Text format    


  370. COLLETI J JR, de Carvalho WB
    First-Line Vasoactive Drugs for Pediatric Septic Shock: Changing the Paradigm?
    Crit Care Med. 2016;44:e232-3.
    PubMed     Text format    


  371. KOLLEF MH, Micek ST
    The authors reply.
    Crit Care Med. 2016;44:e231-2.
    PubMed     Text format    


  372. OSTHOFF M, Sidler JA, Lakatos B, Frei R, et al
    Low-Dose Acetylsalicylic Acid Treatment and Impact on Short-Term Mortality in Staphylococcus aureus Bloodstream Infection: A Propensity Score-Matched Cohort Study.
    Crit Care Med. 2016;44:773-81.
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  373. THIERY-ANTIER N, Binquet C, Vinault S, Meziani F, et al
    Is Thrombocytopenia an Early Prognostic Marker in Septic Shock?
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  374. BRASSARD P, Zaar M, Thaning P, Secher NH, et al
    Sympathetic Vasoconstrictor Responsiveness of the Leg Vasculature During Experimental Endotoxemia and Hypoxia in Humans.
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  375. MINEJIMA E, Bensman J, She RC, Mack WJ, et al
    A Dysregulated Balance of Proinflammatory and Anti-Inflammatory Host Cytokine Response Early During Therapy Predicts Persistence and Mortality in Staphylococcus aureus Bacteremia.
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  376. ATKINSON SJ, Nolan M, Klingbeil L, Harmon K, et al
    Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis.
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  377. JENNEWEIN C, Tran N, Kanczkowski W, Heerdegen L, et al
    Mortality of Septic Mice Strongly Correlates With Adrenal Gland Inflammation.
    Crit Care Med. 2016;44:e190-9.
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  378. RHEE C
    Cytokine Imbalance Predicts Poor Outcomes in Staphylococcus aureus Bacteremia--But What Can We Do About It?
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    March 2016
  379. WANG HE, Donnelly JP, Griffin R, Levitan EB, et al
    Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis.
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  380. SMITH JA, Mayeux PR, Schnellmann RG
    Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis.
    Crit Care Med. 2016.
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  381. SASABUCHI Y, Matsui H, Lefor AK, Fushimi K, et al
    Risks and Benefits of Stress Ulcer Prophylaxis for Patients With Severe Sepsis.
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  382. YENDE S, Austin S, Rhodes A, Finfer S, et al
    Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials.
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  383. ZHANG LA, Parker RS, Swigon D, Banerjee I, et al
    A One-Nearest-Neighbor Approach to Identify the Original Time of Infection Using Censored Baboon Sepsis Data.
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  384. VAN VUGHT LA, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, et al
    Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response.
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  385. BAUMBACH P, Gotz T, Gunther A, Weiss T, et al
    Prevalence and Characteristics of Chronic Intensive Care-Related Pain: The Role of Severe Sepsis and Septic Shock.
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  386. LIU ZJ, Liu JL, Qu HP
    Could Lactate Become a Biomarker of Hypoxia and a Target of Resuscitation in Sepsis?
    Crit Care Med. 2016;44:e178.
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  387. SEYMOUR CW, Coopersmith CM, Deutschman CS, Gesten F, et al
    Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria.
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  388. ANGUS DC, Seymour CW, Coopersmith CM, Deutschman CS, et al
    A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria.
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  389. PRESCOTT HC
    Toward a Nuanced Understanding of the Role of Infection in Readmissions After Sepsis.
    Crit Care Med. 2016;44:634-5.
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  390. CASSERLY B, Levy MM
    The authors reply.
    Crit Care Med. 2016;44:e178-9.
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  391. WILLIAMS JM, Greenslade JH, Chu K, Brown AF, et al
    Severity Scores in Emergency Department Patients With Presumed Infection: A Prospective Validation Study.
    Crit Care Med. 2016;44:539-47.
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  392. HAWARI FI, Nazer LH, Addassi A, Rimawi D, et al
    Predictors of ICU Admission in Patients With Cancer and the Related Characteristics and Outcomes: A 5-Year Registry-Based Study.
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  393. MIKACENIC C, Hansen EE, Radella F, Gharib SA, et al
    Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome.
    Crit Care Med. 2016;44:496-502.
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    February 2016
  394. LEWIS AJ, Yuan D, Zhang X, Angus DC, et al
    Use of Biotelemetry to Define Physiology-Based Deterioration Thresholds in a Murine Cecal Ligation and Puncture Model of Sepsis.
    Crit Care Med. 2016.
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  395. BURNHAM JP, Kollef MH
    Timing of Appropriate Antibiotics in Sepsis: How Much Does Each Hour Matter?
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  396. JOHNSON DW, Kalil AC
    Is Interleukin-1 Receptor Blockade Ready for Prime Time in Patients With Severe Sepsis and Macrophage Activation Syndrome?
    Crit Care Med. 2016;44:443-4.
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  397. CORDEIRO VENTURA A, Shieh HH
    The authors reply.
    Crit Care Med. 2016;44:e111-2.
    PubMed     Text format    


  398. LALGUDI GANESAN S, Jayashree M
    Dopamine in Pediatric Fluid-Refractory Septic Shock: Too Early to Sound the Death Knell?
    Crit Care Med. 2016;44:e110-1.
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  399. STERLING SA, Puskarich MA, Jones AE
    The authors reply.
    Crit Care Med. 2016;44:e110.
    PubMed     Text format    


  400. CROSS A
    Endotoxin: Back to the Future.
    Crit Care Med. 2016;44:450-1.
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  401. SWEENEY DA, Kalil AC
    Choosing the Duration of Therapy for Bacteremia: Keep Calm and Work With Your Infectious Disease and Antibiotic Stewardship Colleagues.
    Crit Care Med. 2016;44:439-40.
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  402. DONNINO MW, Andersen LW, Chase M, Berg KM, et al
    Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Crit Care Med. 2016;44:360-7.
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  403. CHARBONNEY E, Tsang JY, Li Y, Klein D, et al
    Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications.
    Crit Care Med. 2016;44:335-41.
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  404. DANEMAN N, Rishu AH, Xiong W, Bagshaw SM, et al
    Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients.
    Crit Care Med. 2016;44:256-64.
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    January 2016
  405. LI D, Zou L, Feng Y, Xu G, et al
    Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis.
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  406. STANDAGE SW, Waworuntu RL, Delaney MA, Maskal SM, et al
    Nonhematopoietic Peroxisome Proliferator-Activated Receptor-alpha Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis.
    Crit Care Med. 2016.
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  407. NEYRA JA, Canepa-Escaro F, Yee J, Yessayan L, et al
    The authors reply.
    Crit Care Med. 2016;44:e53-4.
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  408. JO S, Jeong T, Lee JB, Jin YH, et al
    Hyperchloremia Versus Nonhyperchloremia or Hyperchloremia Versus Normochloremia?
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  417. WRIGHT BJ, Weingart SD
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  421. SINHA S, Pati J
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  424. ZHOU F, Hongjun K, Hui L, Liang P, et al
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  425. TSAI-NGUYEN G, Endicott-Yazdani T, Smith A, Gardner R, et al
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  426. BITTNER E, Linde-Zwirble W, Hansell D, Sahatjian J, et al
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  427. BATESON M, Hunter A, Patton A, Rooney K, et al
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  428. GANDHI A, Patel R, Victor N
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  429. KATO T, Matsuura K, Nakagawa T, Miki Y, et al
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  430. SOARES A
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  431. ARMAIGNAC D, Fuxa H, Lamoureux J, Valle C, et al
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  432. YNOSENCIO T, Smith A, Endicott-Yazdani T, Gardner R, et al
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  433. SHIH YN, Chen YT, Seethala R, Aisiku I, et al
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  434. BANSAL V, Mangi M, Moreno-Franco P, Emir F, et al
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  435. SANUTH B, Wang K
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  436. HAN M, Fitzgerald J, Balamuth F, Chilutti M, et al
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  437. PAPPADA S, Feeney J, Papadimos T, Salinas J, et al
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  438. AN G, Cockrell C
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  439. KRUER R, Rozycki A, Jarrell A
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  440. NICOLAS L, Samraj R, Philip J
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  443. MATHIEU JF, Boucher S, Pellerin JP
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  458. BINEY I, Amin R, Mehari A
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  459. MENG YH, Chen KF
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  507. SANDQUIST M, Clee M, Patel S, Nagaraj U, et al
    24: HIGH INCIDENCE OF NEUROIMAGING ABNORMALITIES AFTER PEDIATRIC SEPSIS.
    Crit Care Med. 2015;43.
    PubMed     Text format    


  508. SOLEZ K
    Multibiomarker Article Gives a Taste of What the Era of Regenerative Medicine/Tissue Engineering Pathology Will Be Like.
    Crit Care Med. 2015;43:e599-600.
    PubMed     Text format    


  509. VINCENT JL
    The author replies.
    Crit Care Med. 2015;43:e596-7.
    PubMed     Text format    


  510. WALKER CA, Griffith DM, Gray AJ, Datta D, et al
    "Lactate Shift," Rather Than "Lactate Clearance," for Serial Blood Lactate Monitoring?
    Crit Care Med. 2015;43:e596.
    PubMed     Text format    


  511. MICKIEWICZ B, Vogel HJ
    The authors reply.
    Crit Care Med. 2015;43:e593.
    PubMed     Text format    


  512. VISWAN A, Azim A, Sinha N
    Nuclear Magnetic Resonance-Based Metabolic Markers Can Be a True Signature of Diagnosis in Critical Care Setting.
    Crit Care Med. 2015;43:e592-3.
    PubMed     Text format    


  513. JELLY CA, Alston TA
    Release of Endotoxin After an Arrest.
    Crit Care Med. 2015;43:2687-8.
    PubMed     Text format    


  514. VAN DEN BERGH WM
    The Big Difference Between Direct and Nonstop Flights Is the Intermediate Stop Along the Way to the Final Destination.
    Crit Care Med. 2015;43:2685-6.
    PubMed     Text format    


  515. GRIMALDI D, Sauneuf B, Guivarch E, Ricome S, et al
    High Level of Endotoxemia Following Out-of-Hospital Cardiac Arrest Is Associated With Severity and Duration of Postcardiac Arrest Shock.
    Crit Care Med. 2015;43:2597-604.
    PubMed     Text format     Abstract available


  516. CONTENTI J, Occelli C, Corraze H, Lemoel F, et al
    Long-Term beta-Blocker Therapy Decreases Blood Lactate Concentration in Severely Septic Patients.
    Crit Care Med. 2015;43:2616-22.
    PubMed     Text format     Abstract available


    November 2015
  517. SUN A, Netzer G, Small DS, Hanish A, et al
    Association Between Index Hospitalization and Hospital Readmission in Sepsis Survivors.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  518. MASSON S, Caironi P, Fanizza C, Carrer S, et al
    Sequential N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin Measurements During Albumin Replacement in Patients With Severe Sepsis or Septic Shock.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  519. JIANG S, Zhao X, Zhao Y, He X, et al
    Can Spontaneous Hypothermia Induce Higher Mortality in Sepsis?
    Crit Care Med. 2015;43:e528-e529.
    PubMed     Text format    


  520. STALLONE JN
    Corticosteroid Therapy in Sepsis: When Is a Good Thing Too Much of a Good Thing?
    Crit Care Med. 2015;43:2519-2520.
    PubMed     Text format    


  521. HOTCHKISS RS, Crouser E
    Imaging Apoptosis in Sepsis-A Technology We Would Die for!
    Crit Care Med. 2015;43:2506-2508.
    PubMed     Text format    


  522. DREWRY AM, Fuller BM, Skrupky LP, Hotchkiss RS, et al
    The authors reply.
    Crit Care Med. 2015;43:e529-30.
    PubMed     Text format    


  523. WANG Q, Yokoo H, Takashina M, Sakata K, et al
    Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages.
    Crit Care Med. 2015;43:e508-20.
    PubMed     Text format     Abstract available


  524. PANG D, Aneja RK
    Levosimendan for Septic Myocardial Dysfunction: Not Yet Ready for Prime Time.
    Crit Care Med. 2015;43:2522-3.
    PubMed     Text format    


  525. ZIMMERMAN JJ
    On the Threshold of a Dream.
    Crit Care Med. 2015;43:2504-6.
    PubMed     Text format    


  526. LINDER A, Arnold R, Boyd JH, Zindovic M, et al
    Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.
    Crit Care Med. 2015;43:2378-86.
    PubMed     Text format     Abstract available


  527. VINCENT JL, Brealey D, Libert N, Abidi NE, et al
    Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections.
    Crit Care Med. 2015;43:2283-91.
    PubMed     Text format     Abstract available


  528. VENTURA AM, Shieh HH, Bousso A, Goes PF, et al
    Double-Blind Prospective Randomized Controlled Trial of Dopamine Versus Epinephrine as First-Line Vasoactive Drugs in Pediatric Septic Shock.
    Crit Care Med. 2015;43:2292-302.
    PubMed     Text format     Abstract available


  529. AI J, Guo L, Zheng Z, Wang SX, et al
    Corticosteroid Therapy Benefits Septic Mice With Adrenal Insufficiency But Harms Septic Mice Without Adrenal Insufficiency.
    Crit Care Med. 2015;43:e490-8.
    PubMed     Text format     Abstract available


    October 2015
  530. SHAKOORY B, Carcillo JA, Chatham WW, Amdur RL, et al
    Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  531. MASTERSON C, O'Toole D, Leo A, McHale P, et al
    Effects and Mechanisms by Which Hypercapnic Acidosis Inhibits Sepsis-Induced Canonical Nuclear Factor-kappaB Signaling in the Lung.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  532. FORD DW, Goodwin AJ, Simpson AN, Johnson E, et al
    A Severe Sepsis Mortality Prediction Model and Score for Use With Administrative Data.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  533. FAINE BA, Noack JM, Wong T, Messerly JT, et al
    Interhospital Transfer Delays Appropriate Treatment for Patients With Severe Sepsis and Septic Shock: A Retrospective Cohort Study.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  534. SHEN HN, Li CY
    Risk Factors of Readmissions Among Severe Sepsis Survivors.
    Crit Care Med. 2015;43:e461.
    PubMed     Text format    


  535. ZILBERBERG MD, Shorr AF
    Appropriate Antibiotic Treatment in Severe Sepsis and Septic Shock: Timing Is Everything.
    Crit Care Med. 2015;43:2258-9.
    PubMed     Text format    


  536. FEIN IA
    Sepsis Redux: Bigger and Badder Than Ever.
    Crit Care Med. 2015;43:2251-2.
    PubMed     Text format    


  537. RINSCHEN MM
    (Sugar-) Sweet Biomarkers? Clinical Proteomics Enters Sepsis Research.
    Crit Care Med. 2015;43:2245-6.
    PubMed     Text format    


  538. GOODWIN AJ, Rice DA, Simpson KN, Ford DW, et al
    The authors reply.
    Crit Care Med. 2015;43:e461-2.
    PubMed     Text format    


  539. ANNANE D
    Evidence to Practice Gap: The Case of Dopamine.
    Crit Care Med. 2015;43:2259-60.
    PubMed     Text format    


  540. BOERMA EC
    The Future Is Back; Back to the Future!
    Crit Care Med. 2015;43:2253-4.
    PubMed     Text format    


  541. CALZAVACCA P, Evans RG, Bailey M, Bellomo R, et al
    Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury.
    Crit Care Med. 2015;43:e431-9.
    PubMed     Text format     Abstract available


  542. FAWZY A, Evans SR, Walkey AJ
    Practice Patterns and Outcomes Associated With Choice of Initial Vasopressor Therapy for Septic Shock.
    Crit Care Med. 2015;43:2141-6.
    PubMed     Text format     Abstract available


    September 2015
  543. SUN A, Mikkelsen ME
    The Evolution of Sepsis Performance Metrics: From Mortality to Hospital Readmission.
    Crit Care Med. 2015;43:2031-2.
    PubMed     Text format    


  544. SIVAPALAN P, Staehr Jensen JU
    Timing of Therapy in Sepsis: Are Early Antibiotics Important for Prognosis?
    Crit Care Med. 2015;43:2030-1.
    PubMed     Text format    


  545. DELLINGER RP
    The Future of Sepsis Performance Improvement.
    Crit Care Med. 2015;43:1787-9.
    PubMed     Text format    


  546. ZOU L, Chen HH, Li D, Xu G, et al
    Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  547. FREEBAIRN R
    Action and Reaction: The Role of Catecholamine Agonists and Antagonists in Septic Shock.
    Crit Care Med. 2015;43:2039-40.
    PubMed     Text format    


  548. REILLY JP, Christie JD
    Primed for Injury: Cigarette Smokers and Acute Respiratory Distress Syndrome.
    Crit Care Med. 2015;43:2015-6.
    PubMed     Text format    


  549. NEYRA JA, Canepa-Escaro F, Li X, Manllo J, et al
    Association of Hyperchloremia With Hospital Mortality in Critically Ill Septic Patients.
    Crit Care Med. 2015;43:1938-44.
    PubMed     Text format     Abstract available


  550. CALFEE CS, Matthay MA, Kangelaris KN, Siew ED, et al
    Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
    Crit Care Med. 2015;43:1790-7.
    PubMed     Text format     Abstract available


  551. KIMMOUN A, Louis H, Al Kattani N, Delemazure J, et al
    beta1-Adrenergic Inhibition Improves Cardiac and Vascular Function in Experimental Septic Shock.
    Crit Care Med. 2015;43:e332-40.
    PubMed     Text format     Abstract available


    August 2015
  552. ZONNEVELD R, Molema G, Plotz FB
    Analyzing Neutrophil Morphology, Mechanics, and Motility in Sepsis: Options and Challenges for Novel Bedside Technologies.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  553. GUTIERREZ JUNCO SM, Paipa Merchan AJ, Heredia Rodriguez M, Gomez Herreras JI, et al
    The Resuscitation Bundle of the Surviving Sepsis Campaign Beyond Early Goal-Directed Therapy: What's Next?
    Crit Care Med. 2015;43:e319-e320.
    PubMed     Text format    


  554. GINGO MR, Morris A
    HIV Infection and Severe Sepsis: A Bitter Pill to Swallow.
    Crit Care Med. 2015;43:1779-1781.
    PubMed     Text format    


  555. HARRISON AM, Herasevich V, Gajic O
    Automated Sepsis Detection, Alert, and Clinical Decision Support: Act on It or Silence the Alarm?
    Crit Care Med. 2015;43:1776-1777.
    PubMed     Text format    


  556. LEVY MM, Townsend SR, Schorr C, Dellinger RP, et al
    The authors reply.
    Crit Care Med. 2015;43:e320-1.
    PubMed     Text format    


  557. MADSEN TE, Napoli AM
    Factors Associated With Progression to Septic Shock: Why Gender?
    Crit Care Med. 2015;43:e319.
    PubMed     Text format    


  558. WONG HR, Cvijanovich NZ, Anas N, Allen GL, et al
    A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury.
    Crit Care Med. 2015;43:1646-53.
    PubMed     Text format     Abstract available


  559. LIPMAN J, Roberts J
    Does Appropriate Antibiotic Therapy Mean Only Adequate Spectrum and Timing?
    Crit Care Med. 2015;43:1773-4.
    PubMed     Text format    


    July 2015
  560. GUINOT PG, Dupont H, Longrois D
    Some Questioning About the Assessment of Renal Perfusion in Sepsis.
    Crit Care Med. 2015;43:e262-4.
    PubMed     Text format    


  561. SAUTHOFF H, Hay JG
    New Drug for Sepsis on the Cheap?
    Crit Care Med. 2015;43:1551-2.
    PubMed     Text format    


  562. HIGGINS TL
    Variability in Risk-Adjusted Sepsis Mortality: How Much Is Too Much?
    Crit Care Med. 2015;43:1530-1.
    PubMed     Text format    


  563. SCHNELL D, Darmon M
    The authors reply.
    Crit Care Med. 2015;43:e264.
    PubMed     Text format    


  564. GRADWOHL-MATIS I, Dunser MW
    Reverse Physiology: Applying an Antihypertensive Drug to Increase Arterial Blood Pressure in Septic Shock.
    Crit Care Med. 2015;43:1548-50.
    PubMed     Text format    


  565. RAMSEY KM, Akula SM
    Co-Reactivation of Cytomegalovirus and Human Herpesvirus-6 Among ICU Patients: There's Smoke, But Is There Fire?
    Crit Care Med. 2015;43:1539-40.
    PubMed     Text format    


  566. EFRON PA, Mohr AM
    The Monocyte That Wasn't.
    Crit Care Med. 2015;43:1532-4.
    PubMed     Text format    


  567. JIA P, Teng J, Zou J, Fang Y, et al
    Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway.
    Crit Care Med. 2015;43:e250-9.
    PubMed     Text format     Abstract available


  568. LOPEZ ROA P, Hill JA, Kirby KA, Leisenring WM, et al
    Coreactivation of Human Herpesvirus 6 and Cytomegalovirus Is Associated With Worse Clinical Outcome in Critically Ill Adults.
    Crit Care Med. 2015;43:1415-22.
    PubMed     Text format     Abstract available


    June 2015
  569. CHANG DW, Tseng CH, Shapiro MF
    Rehospitalizations Following Sepsis: Common and Costly.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  570. STERLING SA, Miller WR, Pryor J, Puskarich MA, et al
    The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  571. ZHANG D, Micek ST, Kollef MH
    Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients With Sepsis.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  572. ALHAMDI Y, Abrams ST, Cheng Z, Jing S, et al
    Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  573. PAGE DB, Donnelly JP, Wang HE
    Community-, Healthcare-, and Hospital-Acquired Severe Sepsis Hospitalizations in the University HealthSystem Consortium.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  574. KOHLHAUER M, Lidouren F, Remy-Jouet I, Mongardon N, et al
    Hypothermic Total Liquid Ventilation Is Highly Protective Through Cerebral Hemodynamic Preservation and Sepsis-Like Mitigation After Asphyxial Cardiac Arrest.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  575. DECOUX A, Tian Y, DeLeon-Pennell KY, Nguyen NT, et al
    Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  576. QURAISHI SA, De Pascale G, Needleman JS, Nakazawa H, et al
    Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  577. DONNELLY JP, Hohmann SF, Wang HE
    Unplanned Readmissions After Hospitalization for Severe Sepsis at Academic Medical Center-Affiliated Hospitals.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  578. VAN ROESSEL S, van der Laan AM, de Pont AC
    What is the best heparin to treat sepsis with?
    Crit Care Med. 2015;43:e212-3.
    PubMed     Text format    


  579. FULLERTON JN
    Increased mortality in "cold sepsis": the result of a frozen immune response?
    Crit Care Med. 2015;43:1327-9.
    PubMed     Text format    


  580. ZARYCHANSKI R, Kumar A
    The authors reply.
    Crit Care Med. 2015;43:e213.
    PubMed     Text format    


    May 2015
  581. VINCENT JL, Marshall JC, Dellinger RP, Simonson SG, et al
    Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  582. RHEE C, Murphy MV, Li L, Platt R, et al
    Lactate Testing in Suspected Sepsis: Trends and Predictors of Failure to Measure Levels.
    Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  583. RAGHUNATHAN K, Konoske R
    The authors reply.
    Crit Care Med. 2015;43:e156.
    PubMed     Text format    


  584. WEI H, Cao X, Zeng Q, Zhang F, et al
    Ghrelin inhibits proinflammatory responses and prevents cognitive impairment in septic rats.
    Crit Care Med. 2015;43:e143-50.
    PubMed     Text format     Abstract available


  585. SJODING MW, Iwashyna TJ, Dimick JB, Cooke CR, et al
    Gaming hospital-level pneumonia 30-day mortality and readmission measures by legitimate changes to diagnostic coding.
    Crit Care Med. 2015;43:989-95.
    PubMed     Text format     Abstract available


  586. HARRON K, Parslow R, Mok Q, Tibby SM, et al
    Monitoring quality of care through linkage of administrative data: national trends in bloodstream infection in U.K. PICUs 2003-2012.
    Crit Care Med. 2015;43:1070-8.
    PubMed     Text format     Abstract available


  587. LAGU T, Lindenauer P
    Can we make performance measures more resilient to the effects of coding?
    Crit Care Med. 2015;43:1141-3.
    PubMed     Text format    


  588. PUSKARICH MA, Sterling SA
    Decompensation to shock: what is the risk?
    Crit Care Med. 2015;43:1139-40.
    PubMed     Text format    


    April 2015
  589. BUCHMAN TG
    You tell me.
    Crit Care Med. 2015;43:727-8.
    PubMed     Text format    


  590. RAFFRAY L, Douchet I, Augusto JF, Youssef J, et al
    Septic shock sera containing circulating histones induce dendritic cell-regulated necrosis in fatal septic shock patients.
    Crit Care Med. 2015;43:e107-16.
    PubMed     Text format     Abstract available


  591. JESCHKE MG, Pinto R, Kraft R, Nathens AB, et al
    Morbidity and survival probability in burn patients in modern burn care.
    Crit Care Med. 2015;43:808-15.
    PubMed     Text format     Abstract available


  592. ORTEGO A, Gaieski DF, Fuchs BD, Jones T, et al
    Hospital-based acute care use in survivors of septic shock.
    Crit Care Med. 2015;43:729-37.
    PubMed     Text format     Abstract available


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