Retrieve available abstracts of 70 articles: HTML format
Single Articles
September 2025
SAGLIMBENI J, Esteva E, Canales J, Perez OA, et al Peritumoral macrophages recruit eosinophils to promote antitumor immune responses
in breast cancer.
Proc Natl Acad Sci U S A. 2025;122:e2504645122. PubMedAbstract available
ZHANG J, Zhang J, Han L, Wu S, et al Inflammation awakens dormant cancer cells by modulating the
epithelial-mesenchymal phenotypic state.
Proc Natl Acad Sci U S A. 2025;122:e2515009122. PubMedAbstract available
DANG CAO TL, Kawanishi K, Hashimoto S, Hengphasatporn K, et al Tumor-expressed GPNMB orchestrates Siglec-9(+) TAM polarization and EMT to
promote metastasis in triple-negative breast cancer.
Proc Natl Acad Sci U S A. 2025;122:e2503081122. PubMedAbstract available
PERLA S, Stiegler AL, Yi JS, Enyenihi L, et al SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX
transcription factor signaling axis.
Proc Natl Acad Sci U S A. 2025;122:e2503631122. PubMedAbstract available
August 2025
KHAN F, Liu Y, Whitfield D, Pang L, et al Macrophage TBK1 signaling drives the development and outgrowth of breast cancer
brain metastasis.
Proc Natl Acad Sci U S A. 2025;122:e2420793122. PubMedAbstract available
KARNER ER, Wang M, Goel HL, Mercurio AM, et al GATA3 promotes ferroptosis resistance by repressing integrin beta1 signaling.
Proc Natl Acad Sci U S A. 2025;122:e2427304122. PubMedAbstract available
PADRAO N, Gregoricchio S, Eickhoff N, Dong J, et al TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer.
Proc Natl Acad Sci U S A. 2025;122:e2507571122. PubMedAbstract available
VUILLE JA, Tanriover C, Antmen E, Micalizzi DS, et al The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis.
Proc Natl Acad Sci U S A. 2025;122:e2425621122. PubMedAbstract available
July 2025
BOYER JA, Rosen EY, Sharma M, Dorso MA, et al eIF4A controls translation of estrogen receptor alpha and is a therapeutic target
in advanced breast cancer.
Proc Natl Acad Sci U S A. 2025;122:e2424286122. PubMedAbstract available
HORWITZ E, Dubash TD, Szabolcs A, Wittner BS, et al CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy
following mitotic inhibitors.
Proc Natl Acad Sci U S A. 2025;122:e2507203122. PubMedAbstract available
SUN R, Jiang P, Wang Z, Yan B, et al DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and
innate immune response in CDK12-deregulated cancers.
Proc Natl Acad Sci U S A. 2025;122:e2413732122. PubMedAbstract available
BARNET MB, Jackson KJL, Masle-Farquhar E, Russell A, et al Common inherited loss-of-function mutations in the innate sensor NOD2 contribute
to exceptional immune response to cancer immunotherapy.
Proc Natl Acad Sci U S A. 2025;122:e2314258122. PubMedAbstract available
ZOU Y, Wang Z, Jiang Q, Kong X, et al UFMylation: A supervisor of the HIF1alpha pathway and a potential therapeutic target
for anti-PD-1 combination therapy in hypoxic tumors.
Proc Natl Acad Sci U S A. 2025;122:e2500562122. PubMedAbstract available
SURYAWANSHI RK, Patil CD, Borase H, Shukla D, et al Akt isoform specificity drives intrinsic immune regulation during HSV-1
infection.
Proc Natl Acad Sci U S A. 2025;122:e2504962122. PubMedAbstract available
GUO J, Li K, Ming Y, Pan Y, et al A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing
IGF2BP2-mediated c-MYC translation in TNBC.
Proc Natl Acad Sci U S A. 2025;122:e2504320122. PubMedAbstract available
LIM J, Jung HD, Park SY, Jeon M, et al Genome-scale knockout simulation and clustering analysis of drug-resistant breast
cancer cells reveal drug sensitization targets.
Proc Natl Acad Sci U S A. 2025;122:e2425384122. PubMedAbstract available
June 2025
ZENG W, Guo H, Liu Q, Wong WH, et al Improving polygenic prediction from whole-genome sequencing data by leveraging
predicted epigenomic features.
Proc Natl Acad Sci U S A. 2025;122:e2419202122. PubMedAbstract available
OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al Reproductive state controls transcription in the murine liver, with implications
for breast cancer liver metastasis.
Proc Natl Acad Sci U S A. 2025;122:e2420174122. PubMedAbstract available
CROWTHER AJ, Kashem SW, Jewell ME, Le Chang H, et al Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable
mouse model of chronic neuropathic itch.
Proc Natl Acad Sci U S A. 2025;122:e2411724122. PubMedAbstract available
DING Q, Liu J, Wang Y, Kim J, et al Dual-laser "808 and 1,064 nm" strategy that circumvents the Achilles' heel of
photothermal therapy.
Proc Natl Acad Sci U S A. 2025;122:e2503574122. PubMedAbstract available
ZERILLO L, Zotti T, Tutela A, Madera JR, et al The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in
keratinocytes.
Proc Natl Acad Sci U S A. 2025;122:e2500711122. PubMedAbstract available
SHARMA B, Aswin K, Jain T, Nasreen A, et al Mgat4b-mediated selective N-glycosylation regulates melanocyte development and
melanoma progression.
Proc Natl Acad Sci U S A. 2025;122:e2423831122. PubMedAbstract available
May 2025
FERRERO G, Cardamone MD, Luca F, Bourk E, et al Nonproteolytic ubiquitination regulates chromatin occupancy by the
NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells.
Proc Natl Acad Sci U S A. 2025;122:e2502805122. PubMedAbstract available
April 2025
FOFFI E, Rugolo F, Ramamurthy N, Haight J, et al B cell-derived acetylcholine mitigates skin inflammation in mice through alpha9
nicotinic acetylcholine receptor-mediated signaling.
Proc Natl Acad Sci U S A. 2025;122:e2501960122. PubMedAbstract available
CHEN YF, Zhang QH, Zhang ZW, Zhou YJ, et al SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via
altering HER2 trafficking in HER2-positive breast cancer.
Proc Natl Acad Sci U S A. 2025;122:e2417586122. PubMedAbstract available
ZHAO X, Zhao Y, Li Z, Liu H, et al Proximity-activated DNA scanning encoded sequencing for massive access to
membrane proteins nanoscale organization.
Proc Natl Acad Sci U S A. 2025;122:e2425000122. PubMedAbstract available
March 2025
NAZERAI L, Tsiavou C, Vardouli L, Schmiegelow K, et al Thiopurine therapy enhances immune checkpoint inhibitor efficacy in
low-mutational burden melanoma: A promising anticancer approach.
Proc Natl Acad Sci U S A. 2025;122:e2423246122. PubMedAbstract available
STAROSTECKA M, Jeong H, Hasenfeld P, Benito-Garagorri E, et al Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+
breast cancer organoid model.
Proc Natl Acad Sci U S A. 2025;122:e2415475122. PubMedAbstract available
February 2025
YI J, Du J, Chen X, Nie RC, et al A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy
resistance in ER-positive breast cancer.
Proc Natl Acad Sci U S A. 2025;122:e2420383122. PubMedAbstract available
LEI L, Song Y, Yang L, Wang Y, et al Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly
to suppress breast cancer progression and metastasis.
Proc Natl Acad Sci U S A. 2025;122:e2416796122. PubMedAbstract available
January 2025
KRAKOWIAK PA, Flores ME, Cuddy SR, Whitford AL, et al Co-option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for
reactivation from latent infection.
Proc Natl Acad Sci U S A. 2025;122:e2413965122. PubMedAbstract available
CORRALES RM, Vincent J, Crobu L, Neish R, et al Tubulin detyrosination shapes Leishmania cytoskeletal architecture and virulence.
Proc Natl Acad Sci U S A. 2025;122:e2415296122. PubMedAbstract available
QIN G, Shao X, Liu X, Xu J, et al A signaling molecule from intratumor bacteria promotes trastuzumab resistance in
breast cancer cells.
Proc Natl Acad Sci U S A. 2025;122:e2421710122. PubMedAbstract available
ZHENG M, Wang S, Tang K, Kong R, et al The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in
breast cancer cells.
Proc Natl Acad Sci U S A. 2025;122:e2413890121. PubMedAbstract available
December 2024
GONZALEZ-FERNANDEZ M, Perry C, Gerhards NM, Francica P, et al Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by
Huntingtin and BAP1.
Proc Natl Acad Sci U S A. 2024;121:e2402849121. PubMedAbstract available
CATTA-PRETA CMC, Ghosh K, Sacks DL, Ferreira TR, et al Single-cell atlas of Leishmania development in sandflies reveals the
heterogeneity of transmitted parasites and their role in infection.
Proc Natl Acad Sci U S A. 2024;121:e2406776121. PubMedAbstract available
SINHA A, Saini KK, Chandramouli A, Tripathi K, et al ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC
metastasis.
Proc Natl Acad Sci U S A. 2024;121:e2408049121. PubMedAbstract available
MATSUZAKI T, Fujii M, Noro H, Togo S, et al Simultaneous visualization of membrane fluidity and morphology defines adhesion
signatures of cancer cells.
Proc Natl Acad Sci U S A. 2024;121:e2412914121. PubMedAbstract available
ROUBILLE S, Escure T, Juillard F, Corpet A, et al The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1
quiescent genomes.
Proc Natl Acad Sci U S A. 2024;121:e2412258121. PubMedAbstract available
November 2024
KASHYAP MP, Mishra B, Sinha R, Jin L, et al CD2 expressing innate lymphoid and T cells are critical effectors of
immunopathogenesis in hidradenitis suppurativa.
Proc Natl Acad Sci U S A. 2024;121:e2409274121. PubMedAbstract available
LADAK RJ, Choi JH, Luo J, Chen OJ, et al The 4EHP-mediated translational repression of cGAS impedes the host immune
response against DNA viruses.
Proc Natl Acad Sci U S A. 2024;121:e2413018121. PubMedAbstract available
DING X, Liang J, Sharko AC, Hilimire TA, et al Mediator kinase inhibitors suppress triple-negative breast cancer growth and
extend tumor suppression by mTOR and AKT inhibitors.
Proc Natl Acad Sci U S A. 2024;121:e2414501121. PubMedAbstract available
ARULRAJ T, Wang H, Deshpande A, Varadhan R, et al Virtual patient analysis identifies strategies to improve the performance of
predictive biomarkers for PD-1 blockade.
Proc Natl Acad Sci U S A. 2024;121:e2410911121. PubMedAbstract available
October 2024
VALCIKOVA B, Vadovicova N, Smolkova K, Zacpalova M, et al eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
Proc Natl Acad Sci U S A. 2024;121:e2321305121. PubMedAbstract available
LI C, Kaur A, Pavlidaki A, Spenle C, et al Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer,
triggering antitumor immunity.
Proc Natl Acad Sci U S A. 2024;121:e2404485121. PubMedAbstract available
BALDASSARRI I, Tavakol DN, Graney PL, Chramiec AG, et al An engineered model of metastatic colonization of human bone marrow reveals
breast cancer cell remodeling of the hematopoietic niche.
Proc Natl Acad Sci U S A. 2024;121:e2405257121. PubMedAbstract available
ASEMOTA S, Effah W, Holt J, Johnson D, et al A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role
of androgen receptor, JAK-STAT, and lineage plasticity.
Proc Natl Acad Sci U S A. 2024;121:e2406837121. PubMedAbstract available
September 2024
FENG X, Yang C, Huang Y, Su D, et al In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative
breast cancer.
Proc Natl Acad Sci U S A. 2024;121:e2406325121. PubMedAbstract available
LOY CJ, Servellita V, Sotomayor-Gonzalez A, Bliss A, et al Plasma cell-free RNA signatures of inflammatory syndromes in children.
Proc Natl Acad Sci U S A. 2024;121:e2403897121. PubMedAbstract available
August 2024
MUKOHARA F, Iwata K, Ishino T, Inozume T, et al Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity.
Proc Natl Acad Sci U S A. 2024;121:e2320189121. PubMedAbstract available
PIRONON N, Bourrat E, Prost C, Chen M, et al Splice modulation strategy applied to deep intronic variants in COL7A1 causing
recessive dystrophic epidermolysis bullosa.
Proc Natl Acad Sci U S A. 2024;121:e2401781121. PubMedAbstract available
CHIANG HC, Qi L, Mitra P, Huang Y, et al R-loop functions in Brca1-associated mammary tumorigenesis.
Proc Natl Acad Sci U S A. 2024;121:e2403600121. PubMedAbstract available
July 2024
SHAH OS, Nasrazadani A, Foldi J, Atkinson JM, et al Spatial molecular profiling of mixed invasive ductal and lobular breast cancers
reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and
mutations.
Proc Natl Acad Sci U S A. 2024;121:e2322068121. PubMedAbstract available
ZIN I, China A, Khan K, Nag JK, et al AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer
cells.
Proc Natl Acad Sci U S A. 2024;121:e2303642121. PubMedAbstract available
ZHOU Q, Yu H, Chen Y, Ren J, et al The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine
uptake and ferroptosis by modulating SLC7A11.
Proc Natl Acad Sci U S A. 2024;121:e2320655121. PubMedAbstract available
June 2024
DI LEO L, Pagliuca C, Kishk A, Rizza S, et al AMBRA1 levels predict resistance to MAPK inhibitors in melanoma.
Proc Natl Acad Sci U S A. 2024;121:e2400566121. PubMedAbstract available
RUAN ML, Ni WX, Chu JCH, Lam TL, et al Iridium(III) carbene complexes as potent girdin inhibitors against metastatic
cancers.
Proc Natl Acad Sci U S A. 2024;121:e2316615121. PubMedAbstract available
NEBO ID, Frew JW, Gudjonsson JE, Petukhova L, et al Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies.
Proc Natl Acad Sci U S A. 2024;121:e2404503121. PubMed
JIN L, Kashyap MP, Haque ST, Li C, et al Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are
there differences based on anatomical location, gender, and race?
Proc Natl Acad Sci U S A. 2024;121:e2405298121. PubMed
May 2024
Correction for Ichimura et al., Autoimmunity against melanoma
differentiation-associated gene 5 induces interstitial lung disease mimicking
dermatomyositis in mice.
Proc Natl Acad Sci U S A. 2024;121:e2408646121. PubMed
CHEN J, Liu X, Zou Y, Gong J, et al A high-fat diet promotes cancer progression by inducing gut microbiota-mediated
leucine production and PMN-MDSC differentiation.
Proc Natl Acad Sci U S A. 2024;121:e2306776121. PubMedAbstract available
ASHOKAN A, Sarkar S, Kamran MZ, Surnar B, et al Simultaneous targeting of peripheral and brain tumors with a therapeutic
nanoparticle to disrupt metabolic adaptability at both sites.
Proc Natl Acad Sci U S A. 2024;121:e2318119121. PubMedAbstract available
GOYETTE MA, Stevens LE, DePinho CR, Seehawer M, et al Cancer-stromal cell interactions in breast cancer brain metastases induce
glycocalyx-mediated resistance to HER2-targeting therapies.
Proc Natl Acad Sci U S A. 2024;121:e2322688121. PubMedAbstract available
April 2024
MONDAL DK, Xie C, Pascal GJ, Buraschi S, et al Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer
progression.
Proc Natl Acad Sci U S A. 2024;121:e2317760121. PubMedAbstract available
ICHIMURA Y, Konishi R, Shobo M, Tanaka R, et al Autoimmunity against melanoma differentiation-associated gene 5 induces
interstitial lung disease mimicking dermatomyositis in mice.
Proc Natl Acad Sci U S A. 2024;121:e2313070121. PubMedAbstract available
PIRES L, Khattak S, Pratavieira S, Calcada C, et al Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates
malignant melanoma.
Proc Natl Acad Sci U S A. 2024;121:e2316303121. PubMedAbstract available
March 2024
WANG D, Tang M, Zhang P, Yang K, et al Activation of ERbeta hijacks the splicing machinery to trigger R-loop formation in
triple-negative breast cancer.
Proc Natl Acad Sci U S A. 2024;121:e2306814121. PubMedAbstract available
GOUPIL E, Lacroix L, Briere J, Guga S, et al OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the
intercellular bridge in late cytokinesis.
Proc Natl Acad Sci U S A. 2024;121:e2308570121. PubMedAbstract available
TAYLOR-PHILLIPS S, Jenkinson D, Stinton C, Kunar MA, et al Fatigue and vigilance in medical experts detecting breast cancer.
Proc Natl Acad Sci U S A. 2024;121:e2309576121. PubMedAbstract available
LAMIA KA Telling time in tumor samples reveals diversity of clock disruption.
Proc Natl Acad Sci U S A. 2024;121:e2401496121. PubMed