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Articles published in Proc Natl Acad Sci U S A

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Single Articles


    November 2025
  1. AYLON Y, Furth N, Pirona AC, Lavie A, et al
    p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2522646122.
    PubMed     Abstract available


    October 2025
  2. PIERCE SB, Kortbawi H, Gulsuner S, Mandell JB, et al
    Genetic regulation of the estrogen receptor and inherited predisposition to breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2517736122.
    PubMed     Abstract available


  3. BERGMAN RE, Keeton CI, Sinha IR, Ling JP, et al
    Distinct and convergent effects of SF3B1 mutations in human breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2505374122.
    PubMed     Abstract available


    September 2025
  4. SAGLIMBENI J, Esteva E, Canales J, Perez OA, et al
    Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2504645122.
    PubMed     Abstract available


  5. ZHANG J, Zhang J, Han L, Wu S, et al
    Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state.
    Proc Natl Acad Sci U S A. 2025;122:e2515009122.
    PubMed     Abstract available


  6. DANG CAO TL, Kawanishi K, Hashimoto S, Hengphasatporn K, et al
    Tumor-expressed GPNMB orchestrates Siglec-9(+) TAM polarization and EMT to promote metastasis in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2503081122.
    PubMed     Abstract available


  7. PERLA S, Stiegler AL, Yi JS, Enyenihi L, et al
    SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
    Proc Natl Acad Sci U S A. 2025;122:e2503631122.
    PubMed     Abstract available


    August 2025
  8. KHAN F, Liu Y, Whitfield D, Pang L, et al
    Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420793122.
    PubMed     Abstract available


  9. KARNER ER, Wang M, Goel HL, Mercurio AM, et al
    GATA3 promotes ferroptosis resistance by repressing integrin beta1 signaling.
    Proc Natl Acad Sci U S A. 2025;122:e2427304122.
    PubMed     Abstract available


  10. PADRAO N, Gregoricchio S, Eickhoff N, Dong J, et al
    TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2507571122.
    PubMed     Abstract available


  11. VUILLE JA, Tanriover C, Antmen E, Micalizzi DS, et al
    The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2425621122.
    PubMed     Abstract available


    July 2025
  12. BOYER JA, Rosen EY, Sharma M, Dorso MA, et al
    eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2424286122.
    PubMed     Abstract available


  13. HORWITZ E, Dubash TD, Szabolcs A, Wittner BS, et al
    CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.
    Proc Natl Acad Sci U S A. 2025;122:e2507203122.
    PubMed     Abstract available


  14. SUN R, Jiang P, Wang Z, Yan B, et al
    DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers.
    Proc Natl Acad Sci U S A. 2025;122:e2413732122.
    PubMed     Abstract available


  15. BARNET MB, Jackson KJL, Masle-Farquhar E, Russell A, et al
    Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy.
    Proc Natl Acad Sci U S A. 2025;122:e2314258122.
    PubMed     Abstract available


  16. ZOU Y, Wang Z, Jiang Q, Kong X, et al
    UFMylation: A supervisor of the HIF1alpha pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors.
    Proc Natl Acad Sci U S A. 2025;122:e2500562122.
    PubMed     Abstract available


  17. SURYAWANSHI RK, Patil CD, Borase H, Shukla D, et al
    Akt isoform specificity drives intrinsic immune regulation during HSV-1 infection.
    Proc Natl Acad Sci U S A. 2025;122:e2504962122.
    PubMed     Abstract available


  18. GUO J, Li K, Ming Y, Pan Y, et al
    A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
    Proc Natl Acad Sci U S A. 2025;122:e2504320122.
    PubMed     Abstract available


  19. LIM J, Jung HD, Park SY, Jeon M, et al
    Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets.
    Proc Natl Acad Sci U S A. 2025;122:e2425384122.
    PubMed     Abstract available


    June 2025
  20. ZENG W, Guo H, Liu Q, Wong WH, et al
    Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features.
    Proc Natl Acad Sci U S A. 2025;122:e2419202122.
    PubMed     Abstract available


  21. OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al
    Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420174122.
    PubMed     Abstract available


  22. CROWTHER AJ, Kashem SW, Jewell ME, Le Chang H, et al
    Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.
    Proc Natl Acad Sci U S A. 2025;122:e2411724122.
    PubMed     Abstract available


  23. DING Q, Liu J, Wang Y, Kim J, et al
    Dual-laser "808 and 1,064 nm" strategy that circumvents the Achilles' heel of photothermal therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2503574122.
    PubMed     Abstract available


  24. ZERILLO L, Zotti T, Tutela A, Madera JR, et al
    The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes.
    Proc Natl Acad Sci U S A. 2025;122:e2500711122.
    PubMed     Abstract available


  25. SHARMA B, Aswin K, Jain T, Nasreen A, et al
    Mgat4b-mediated selective N-glycosylation regulates melanocyte development and melanoma progression.
    Proc Natl Acad Sci U S A. 2025;122:e2423831122.
    PubMed     Abstract available


    May 2025
  26. FERRERO G, Cardamone MD, Luca F, Bourk E, et al
    Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2502805122.
    PubMed     Abstract available


    April 2025
  27. FOFFI E, Rugolo F, Ramamurthy N, Haight J, et al
    B cell-derived acetylcholine mitigates skin inflammation in mice through alpha9 nicotinic acetylcholine receptor-mediated signaling.
    Proc Natl Acad Sci U S A. 2025;122:e2501960122.
    PubMed     Abstract available


  28. CHEN YF, Zhang QH, Zhang ZW, Zhou YJ, et al
    SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2417586122.
    PubMed     Abstract available


  29. ZHAO X, Zhao Y, Li Z, Liu H, et al
    Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization.
    Proc Natl Acad Sci U S A. 2025;122:e2425000122.
    PubMed     Abstract available


    March 2025
  30. NAZERAI L, Tsiavou C, Vardouli L, Schmiegelow K, et al
    Thiopurine therapy enhances immune checkpoint inhibitor efficacy in low-mutational burden melanoma: A promising anticancer approach.
    Proc Natl Acad Sci U S A. 2025;122:e2423246122.
    PubMed     Abstract available


  31. STAROSTECKA M, Jeong H, Hasenfeld P, Benito-Garagorri E, et al
    Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model.
    Proc Natl Acad Sci U S A. 2025;122:e2415475122.
    PubMed     Abstract available


    February 2025
  32. YI J, Du J, Chen X, Nie RC, et al
    A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2420383122.
    PubMed     Abstract available


  33. LEI L, Song Y, Yang L, Wang Y, et al
    Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2416796122.
    PubMed     Abstract available


    January 2025
  34. KRAKOWIAK PA, Flores ME, Cuddy SR, Whitford AL, et al
    Co-option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection.
    Proc Natl Acad Sci U S A. 2025;122:e2413965122.
    PubMed     Abstract available


  35. CORRALES RM, Vincent J, Crobu L, Neish R, et al
    Tubulin detyrosination shapes Leishmania cytoskeletal architecture and virulence.
    Proc Natl Acad Sci U S A. 2025;122:e2415296122.
    PubMed     Abstract available


  36. QIN G, Shao X, Liu X, Xu J, et al
    A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2421710122.
    PubMed     Abstract available


  37. ZHENG M, Wang S, Tang K, Kong R, et al
    The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2413890121.
    PubMed     Abstract available


    December 2024
  38. GONZALEZ-FERNANDEZ M, Perry C, Gerhards NM, Francica P, et al
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1.
    Proc Natl Acad Sci U S A. 2024;121:e2402849121.
    PubMed     Abstract available


  39. CATTA-PRETA CMC, Ghosh K, Sacks DL, Ferreira TR, et al
    Single-cell atlas of Leishmania development in sandflies reveals the heterogeneity of transmitted parasites and their role in infection.
    Proc Natl Acad Sci U S A. 2024;121:e2406776121.
    PubMed     Abstract available


  40. SINHA A, Saini KK, Chandramouli A, Tripathi K, et al
    ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis.
    Proc Natl Acad Sci U S A. 2024;121:e2408049121.
    PubMed     Abstract available


  41. MATSUZAKI T, Fujii M, Noro H, Togo S, et al
    Simultaneous visualization of membrane fluidity and morphology defines adhesion signatures of cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2412914121.
    PubMed     Abstract available


  42. ROUBILLE S, Escure T, Juillard F, Corpet A, et al
    The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes.
    Proc Natl Acad Sci U S A. 2024;121:e2412258121.
    PubMed     Abstract available


    November 2024
  43. KASHYAP MP, Mishra B, Sinha R, Jin L, et al
    CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa.
    Proc Natl Acad Sci U S A. 2024;121:e2409274121.
    PubMed     Abstract available


  44. LADAK RJ, Choi JH, Luo J, Chen OJ, et al
    The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses.
    Proc Natl Acad Sci U S A. 2024;121:e2413018121.
    PubMed     Abstract available


  45. DING X, Liang J, Sharko AC, Hilimire TA, et al
    Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors.
    Proc Natl Acad Sci U S A. 2024;121:e2414501121.
    PubMed     Abstract available


  46. ARULRAJ T, Wang H, Deshpande A, Varadhan R, et al
    Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade.
    Proc Natl Acad Sci U S A. 2024;121:e2410911121.
    PubMed     Abstract available


    October 2024
  47. VALCIKOVA B, Vadovicova N, Smolkova K, Zacpalova M, et al
    eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
    Proc Natl Acad Sci U S A. 2024;121:e2321305121.
    PubMed     Abstract available


  48. LI C, Kaur A, Pavlidaki A, Spenle C, et al
    Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2404485121.
    PubMed     Abstract available


  49. BALDASSARRI I, Tavakol DN, Graney PL, Chramiec AG, et al
    An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche.
    Proc Natl Acad Sci U S A. 2024;121:e2405257121.
    PubMed     Abstract available


  50. ASEMOTA S, Effah W, Holt J, Johnson D, et al
    A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity.
    Proc Natl Acad Sci U S A. 2024;121:e2406837121.
    PubMed     Abstract available


    September 2024
  51. FENG X, Yang C, Huang Y, Su D, et al
    In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2406325121.
    PubMed     Abstract available


  52. LOY CJ, Servellita V, Sotomayor-Gonzalez A, Bliss A, et al
    Plasma cell-free RNA signatures of inflammatory syndromes in children.
    Proc Natl Acad Sci U S A. 2024;121:e2403897121.
    PubMed     Abstract available


    August 2024
  53. MUKOHARA F, Iwata K, Ishino T, Inozume T, et al
    Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2320189121.
    PubMed     Abstract available


  54. PIRONON N, Bourrat E, Prost C, Chen M, et al
    Splice modulation strategy applied to deep intronic variants in COL7A1 causing recessive dystrophic epidermolysis bullosa.
    Proc Natl Acad Sci U S A. 2024;121:e2401781121.
    PubMed     Abstract available


  55. CHIANG HC, Qi L, Mitra P, Huang Y, et al
    R-loop functions in Brca1-associated mammary tumorigenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2403600121.
    PubMed     Abstract available


    July 2024
  56. SHAH OS, Nasrazadani A, Foldi J, Atkinson JM, et al
    Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
    Proc Natl Acad Sci U S A. 2024;121:e2322068121.
    PubMed     Abstract available


  57. ZIN I, China A, Khan K, Nag JK, et al
    AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2303642121.
    PubMed     Abstract available


  58. ZHOU Q, Yu H, Chen Y, Ren J, et al
    The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11.
    Proc Natl Acad Sci U S A. 2024;121:e2320655121.
    PubMed     Abstract available


    June 2024
  59. DI LEO L, Pagliuca C, Kishk A, Rizza S, et al
    AMBRA1 levels predict resistance to MAPK inhibitors in melanoma.
    Proc Natl Acad Sci U S A. 2024;121:e2400566121.
    PubMed     Abstract available


  60. RUAN ML, Ni WX, Chu JCH, Lam TL, et al
    Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers.
    Proc Natl Acad Sci U S A. 2024;121:e2316615121.
    PubMed     Abstract available


  61. NEBO ID, Frew JW, Gudjonsson JE, Petukhova L, et al
    Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies.
    Proc Natl Acad Sci U S A. 2024;121:e2404503121.
    PubMed    


  62. JIN L, Kashyap MP, Haque ST, Li C, et al
    Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race?
    Proc Natl Acad Sci U S A. 2024;121:e2405298121.
    PubMed    


    May 2024

  63. Correction for Ichimura et al., Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2408646121.
    PubMed    


  64. CHEN J, Liu X, Zou Y, Gong J, et al
    A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation.
    Proc Natl Acad Sci U S A. 2024;121:e2306776121.
    PubMed     Abstract available


  65. ASHOKAN A, Sarkar S, Kamran MZ, Surnar B, et al
    Simultaneous targeting of peripheral and brain tumors with a therapeutic nanoparticle to disrupt metabolic adaptability at both sites.
    Proc Natl Acad Sci U S A. 2024;121:e2318119121.
    PubMed     Abstract available


  66. GOYETTE MA, Stevens LE, DePinho CR, Seehawer M, et al
    Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Proc Natl Acad Sci U S A. 2024;121:e2322688121.
    PubMed     Abstract available


    April 2024
  67. MONDAL DK, Xie C, Pascal GJ, Buraschi S, et al
    Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.
    Proc Natl Acad Sci U S A. 2024;121:e2317760121.
    PubMed     Abstract available


  68. ICHIMURA Y, Konishi R, Shobo M, Tanaka R, et al
    Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2313070121.
    PubMed     Abstract available


  69. PIRES L, Khattak S, Pratavieira S, Calcada C, et al
    Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma.
    Proc Natl Acad Sci U S A. 2024;121:e2316303121.
    PubMed     Abstract available


    March 2024
  70. WANG D, Tang M, Zhang P, Yang K, et al
    Activation of ERbeta hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2306814121.
    PubMed     Abstract available


  71. GOUPIL E, Lacroix L, Briere J, Guga S, et al
    OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis.
    Proc Natl Acad Sci U S A. 2024;121:e2308570121.
    PubMed     Abstract available


  72. TAYLOR-PHILLIPS S, Jenkinson D, Stinton C, Kunar MA, et al
    Fatigue and vigilance in medical experts detecting breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2309576121.
    PubMed     Abstract available


  73. LAMIA KA
    Telling time in tumor samples reveals diversity of clock disruption.
    Proc Natl Acad Sci U S A. 2024;121:e2401496121.
    PubMed    


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