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Articles published in J Clin Invest

Retrieve available abstracts of 90 articles:
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Single Articles


    March 2026
  1. DE STEFANO MA, Ambrosio R, Luongo C, Porcelli T, et al
    Type 2 deiodinase-dependent surge in thyroid hormone controls muscle stem cell quiescence and self-renewal.
    J Clin Invest. 2026 Mar 5:e194925. doi: 10.1172/JCI194925.
    PubMed     Abstract available


  2. SONG P, Chen C, Franchini R, Duong B, et al
    N-acetyl-l-leucine lowers alpha-synuclein levels and improves synaptic function in Parkinson's disease models.
    J Clin Invest. 2026;136:e196137.
    PubMed     Abstract available


  3. SUN R, Gao C, Lu RO
    Tumor-intrinsic chromatin programs enforce immune evasion in glioblastoma.
    J Clin Invest. 2026;136:e203222.
    PubMed     Abstract available


  4. ZHU X, John AJ, Kim S, Wang L, et al
    Alcohol use disorder-associated gene FNDC4 alters glutamatergic and GABAergic neurogenesis in neural organoids.
    J Clin Invest. 2026;136:e193204.
    PubMed     Abstract available


    February 2026
  5. MARTENS MJ, Dutta D, Yu Y, Rein LE, et al
    The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers.
    J Clin Invest. 2026;136:e195228.
    PubMed     Abstract available


  6. KONISHI S, Enkhbayar K, Liu S, Miyashita N, et al
    TP53/TAU axis regulates microtubule bundling to control alveolar stem cell mediated regeneration.
    J Clin Invest. 2026 Feb 5:e194762. doi: 10.1172/JCI194762.
    PubMed     Abstract available


  7. CHEN S, Barajas S, Vemula S, Yang Y, et al
    Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.
    J Clin Invest. 2025;136:e184285.
    PubMed     Abstract available


    January 2026
  8. WU Z, Li N, Luo Z, Chen Z, et al
    Corrigendum to Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.
    J Clin Invest. 2026;136:e203674.
    PubMed    


  9. YUAN F, Wu X, Yuan H, Wang D, et al
    Glioblastoma stem cells resist cuproptosis with circadian variation of copper levels.
    J Clin Invest. 2026;136:e192599.
    PubMed     Abstract available


  10. WU H, Zhong X, Ma N, He Z, et al
    Selective disruption of RORgammat-CBFbeta interaction by IMU-935 prevents RORgammat-dependent Th17 autoimmunity but not thymocyte development.
    J Clin Invest. 2026;136:e185942.
    PubMed     Abstract available


    December 2025
  11. CHEN HC, Bang MF, Wang HH, Shpargel KB, et al
    UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes.
    J Clin Invest. 2025 Dec 16:e196325. doi: 10.1172/JCI196325.
    PubMed     Abstract available


  12. LEUNG CON, Gurung S, Chung KPS, Leung RWH, et al
    Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver-induced hepatocellular carcinoma by driving ITGB1-mediated beta-catenin activation.
    J Clin Invest. 2025;135:e182322.
    PubMed     Abstract available


  13. ADACHI Y, Chen W, Zhang C, Wang T, et al
    Targeting kinesin family member 20A sensitizes stem-like triple-negative breast cancer cells to standard chemotherapy.
    J Clin Invest. 2025;135:e182394.
    PubMed     Abstract available


  14. GU H, Weng L, Chen C, Hao X, et al
    Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche.
    J Clin Invest. 2025;135:e189051.
    PubMed     Abstract available


  15. WU Z, Li N, Luo Z, Chen Z, et al
    Expression of Concern for Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.
    J Clin Invest. 2025;135:e202595.
    PubMed    


    November 2025
  16. KINCROSS H, Mo YA, Wang X, Chang L, et al
    Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1.
    J Clin Invest. 2025 Nov 25:e181943. doi: 10.1172/JCI181943.
    PubMed     Abstract available


  17. LIN Y, Gu Q, Lu S, Pan Z, et al
    Corrigendum to Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease.
    J Clin Invest. 2025;135:e200847.
    PubMed    


  18. TAMBRALLI A, Knight JS
    Neutrophils take center stage in VEXAS syndrome pathogenesis.
    J Clin Invest. 2025;135:e199299.
    PubMed     Abstract available


  19. DONG G, Liu J, Jin W, Zhou H, et al
    UBA1-depleted neutrophils disrupt immune homeostasis and induce VEXAS-like autoinflammatory disease in mice.
    J Clin Invest. 2025;135:e193011.
    PubMed     Abstract available


    October 2025
  20. SINGH B, Hossain MA, Liang XH, Fages J, et al
    Lnk Deficiency Enhances Translesion Synthesis to Alleviate Replication Stress and Promote Hematopoietic Stem Cell Fitness.
    J Clin Invest. 2025 Oct 30:e191713. doi: 10.1172/JCI191713.
    PubMed     Abstract available


  21. MULLIN C, Lin K, Choe E, Sha C, et al
    The hematopoietic stem cell MYB enhancer is essential and recurrently amplified during T-cell leukemogenesis.
    J Clin Invest. 2025 Oct 23:e187998. doi: 10.1172/JCI187998.
    PubMed     Abstract available


  22. MEI Y, Xu Y, Zhang X, Feng B, et al
    3D cultured human medium spiny neurons functionally integrate and rescue motor deficits in Huntington's disease mice.
    J Clin Invest. 2025;135:e187941.
    PubMed     Abstract available


  23. MO J, Anastasaki C, Chen Z, Shipman T, et al
    Corrigendum for Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.
    J Clin Invest. 2025;135:e199700.
    PubMed    


  24. WU Z, Li N, Luo Z, Chen Z, et al
    Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.
    J Clin Invest. 2025;135:e193014.
    PubMed     Abstract available


  25. DUVAL AJ, Seker-Polat F, Rogozinska M, Kinali M, et al
    SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer.
    J Clin Invest. 2025;135:e186467.
    PubMed     Abstract available


    September 2025
  26. PARK SH, Cheon DH, Kim YM, Choi Y, et al
    NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models.
    J Clin Invest. 2025;135:e183093.
    PubMed     Abstract available


  27. JI L, Yan J, Losurdo NA, Wang H, et al
    Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.
    J Clin Invest. 2025;135:e186119.
    PubMed     Abstract available


  28. YANG J, Jiang Z, Fitzgerald DC, Ma C, et al
    Retraction of Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.
    J Clin Invest. 2025;135:e198608.
    PubMed    


  29. VIRGILIO E, Tielens S, Bonfield G, Nian FS, et al
    Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome.
    J Clin Invest. 2025 Sep 9:e195756. doi: 10.1172/JCI195756.
    PubMed     Abstract available


  30. DENG Z, Law CS, Kurra S, Simchoni N, et al
    Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity.
    J Clin Invest. 2025;135:e180252.
    PubMed     Abstract available


  31. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Corrigendum to Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2025;135:e198274.
    PubMed    


    August 2025
  32. XU T, Heon-Roberts R, Moore T, Dubot P, et al
    Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.
    J Clin Invest. 2025;135:e177430.
    PubMed     Abstract available


    July 2025
  33. SAKA S, Lu Z, Wang Y, Liu P, et al
    Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice.
    J Clin Invest. 2025 Jul 29:e188140. doi: 10.1172/JCI188140.
    PubMed     Abstract available


  34. SHAO JS, Lai AC, Huang WC, Wu KC, et al
    Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s.
    J Clin Invest. 2025 Jul 17:e187372. doi: 10.1172/JCI187372.
    PubMed     Abstract available


  35. SINGH AK, Bernabucci M, Dvorak NM, Haghighijoo Z, et al
    Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.
    J Clin Invest. 2025;135:e183749.
    PubMed     Abstract available


  36. HUGHES EP, Syage AR, Mirzaei Mehrabad E, Lane TE, et al
    OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.
    J Clin Invest. 2025;135:e187862.
    PubMed     Abstract available


    June 2025
  37. TOMISHIMA SA, Kim DD, Porter N, Guha I, et al
    The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice.
    J Clin Invest. 2025 Jun 26:e180913. doi: 10.1172/JCI180913.
    PubMed     Abstract available


    May 2025
  38. D'ADDIO F, Amabile G, Assi E, Maestroni A, et al
    TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.
    J Clin Invest. 2025;135:e185783.
    PubMed     Abstract available


  39. SCHLEGEL N
    Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial stem cell defects in inflammatory bowel disease.
    J Clin Invest. 2025;135:e192640.
    PubMed     Abstract available


  40. HUANG Y, Xie X, Liu M, Zhang Y, et al
    Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.
    J Clin Invest. 2025;135:e183607.
    PubMed     Abstract available


    April 2025
  41. GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al
    Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes.
    J Clin Invest. 2025;135:e183513.
    PubMed     Abstract available


  42. GAO C, Dai Y, Spezza PA, Boasiako P, et al
    Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation.
    J Clin Invest. 2025;135:e189801.
    PubMed     Abstract available


  43. KANG M, Choi J, Han J, Araki T, et al
    Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.
    J Clin Invest. 2025;135:e176631.
    PubMed     Abstract available


    March 2025
  44. DELAFONTAINE S, Meyts I
    Oncostatin M silence and neopeptide: the value of exploring patients with rare inherited bone marrow failure.
    J Clin Invest. 2025;135:e190955.
    PubMed     Abstract available


    February 2025
  45. LI H, Liu P, Xu S, Li Y, et al
    FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
    J Clin Invest. 2025;135:e191424.
    PubMed    


  46. WEI W, Gao X, Qian J, Li L, et al
    Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival.
    J Clin Invest. 2025;135:e177375.
    PubMed     Abstract available


    January 2025
  47. HAMAMOTO K, Zhu G, Lai Q, Lesperance J, et al
    HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.
    J Clin Invest. 2025;135:e184743.
    PubMed     Abstract available


  48. CUI X, Hou L, Yan B, Liu J, et al
    Sex dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling.
    J Clin Invest. 2025 Jan 21:e182125. doi: 10.1172/JCI182125.
    PubMed     Abstract available


  49. GRIFFITH JW, Luster AD
    No bones about it: regulatory T cells promote fracture healing.
    J Clin Invest. 2025;135:e188368.
    PubMed     Abstract available


  50. LI J, Bai J, Pham VT, Hashimoto M, et al
    Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells.
    J Clin Invest. 2025 Jan 9:e184069. doi: 10.1172/JCI184069.
    PubMed     Abstract available


  51. CHEN S, Huang C, Li K, Cheng M, et al
    Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice.
    J Clin Invest. 2025;135:e180893.
    PubMed     Abstract available


  52. CHEN YT, Jiang MM, Leynes C, Adeyeye M, et al
    ATRX silences Cartpt expression in osteoblastic cells during skeletal development.
    J Clin Invest. 2025;135:e163587.
    PubMed     Abstract available


  53. CAMPBELL K, Li Q
    Clonal hematopoiesis JAKs up plaque formation.
    J Clin Invest. 2025;135:e187529.
    PubMed     Abstract available


  54. WANG BZ, Morsink MA, Kim SW, Luo LJ, et al
    Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
    J Clin Invest. 2025;135:e181630.
    PubMed     Abstract available


    December 2024
  55. SAARELA D, Lis P, Gomes S, Nirujogi RS, et al
    Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.
    J Clin Invest. 2024;135:e183592.
    PubMed     Abstract available


  56. DEFAMIE V, Aliar K, Sarkar S, Vyas F, et al
    Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury.
    J Clin Invest. 2024;135:e164997.
    PubMed     Abstract available


  57. KIM Y, Kim SW, Saul D, Neyazi M, et al
    Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
    J Clin Invest. 2024;135:e183353.
    PubMed     Abstract available


  58. WU Q, Yu C, Yu F, Guo Y, et al
    Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells.
    J Clin Invest. 2024;134:e173403.
    PubMed     Abstract available


  59. PEACH T, Quattrocelli M
    The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals.
    J Clin Invest. 2024;134:e185054.
    PubMed     Abstract available


  60. WANG Q, Hu T, Zhang Q, Zhang Y, et al
    Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells.
    J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595.
    PubMed     Abstract available


    November 2024
  61. NAYAK RC, Emberesh S, Trump LR, Wellendorf AM, et al
    G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates.
    J Clin Invest. 2024;135:e177342.
    PubMed     Abstract available


  62. WANG S, Huang T, Wu Q, Yuan H, et al
    Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation.
    J Clin Invest. 2024;134:e176851.
    PubMed     Abstract available


  63. ANCEL S, Michaud J, Migliavacca E, Jomard C, et al
    Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
    J Clin Invest. 2024 Nov 12:e163648. doi: 10.1172/JCI163648.
    PubMed     Abstract available


  64. PALLAVICINI G, Moccia A, Iegiani G, Parolisi R, et al
    Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity.
    J Clin Invest. 2024;134:e175435.
    PubMed     Abstract available


    October 2024
  65. LIU Q, Huang J, Ding H, Tao Y, et al
    Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity.
    J Clin Invest. 2024;134:e177077.
    PubMed     Abstract available


  66. SINHA S, Callow BW, Farfel AP, Roy S, et al
    Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels.
    J Clin Invest. 2024;134:e170953.
    PubMed     Abstract available


  67. GHOTBI E, Tchegnon E, Chen Z, Li S, et al
    Transcription factor KROX20 marks epithelial stem cells for hair follicle formation.
    J Clin Invest. 2024 Oct 3:e180160. doi: 10.1172/JCI180160.
    PubMed     Abstract available


  68. CHEN CL, Tsukamoto H, Liu JC, Kashiwabara C, et al
    Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
    J Clin Invest. 2024;134:e186923.
    PubMed    


    September 2024
  69. YANG H, Ping X, Zhou J, Ailifeire H, et al
    Reversible cold-induced lens opacity in a hibernator reveals a molecular target for treating cataracts.
    J Clin Invest. 2024;134:e169666.
    PubMed     Abstract available


  70. LIU H, Zhao XF, Lu YN, Hayes LR, et al
    CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA.
    J Clin Invest. 2024;134:e179016.
    PubMed     Abstract available


  71. DESCHAMPS P, Wacheux M, Gosseye A, Morabito M, et al
    CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia.
    J Clin Invest. 2024;134:e180738.
    PubMed     Abstract available


  72. XING W, Feng H, Jiang B, Gao B, et al
    Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing.
    J Clin Invest. 2024;134:e176528.
    PubMed     Abstract available


    August 2024
  73. BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al
    Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single cell analyses.
    J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331.
    PubMed     Abstract available


  74. WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al
    MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.
    J Clin Invest. 2024;134:e168393.
    PubMed     Abstract available


  75. SRIDHAR A, DeSantiago J, Chen H, Pavel MA, et al
    Modulation of NOX2 causes obesity-mediated atrial fibrillation.
    J Clin Invest. 2024;134:e175447.
    PubMed     Abstract available


  76. SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al
    CHIP: a clonal odyssey of the bone marrow niche.
    J Clin Invest. 2024;134:e180068.
    PubMed     Abstract available


    July 2024
  77. WU K, Zhang Y, Yin-DeClue H, Sun K, et al
    A correctable immune niche for epithelial stem-cell reprogramming and post-viral lung diseases.
    J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092.
    PubMed     Abstract available


    June 2024
  78. MAROM R, Song IW, Busse EC, Washington ME, et al
    The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.
    J Clin Invest. 2024;134:e170369.
    PubMed     Abstract available


    May 2024
  79. SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al
    Susceptibility to innate immune activation in genetically mediated myocarditis.
    J Clin Invest. 2024;134:e180254.
    PubMed     Abstract available


  80. SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al
    Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
    J Clin Invest. 2024;134:e179834.
    PubMed     Abstract available


  81. LEOW DM, Ng YK, Wang LC, Koh HW, et al
    Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy.
    J Clin Invest. 2024;134:e173702.
    PubMed     Abstract available


  82. LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al
    Generation of allogenic and xenogeneic functional muscle stem cells for intramuscular transplantation.
    J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998.
    PubMed     Abstract available


    April 2024
  83. MOE A, Rayasam A, Sauber G, Shah RK, et al
    Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease.
    J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205.
    PubMed     Abstract available


  84. SONG X, Tiek D, Miki S, Huang T, et al
    RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.
    J Clin Invest. 2024;134:e173789.
    PubMed     Abstract available


  85. KEAN LS, Blazar BR
    Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation.
    J Clin Invest. 2024;134:e179944.
    PubMed    


  86. NORTH D, Chakraverty R
    The road to refractory graft-versus-host disease is paved with good intentions.
    J Clin Invest. 2024;134:e177728.
    PubMed     Abstract available


  87. ZHANG P, Fleming P, Andoniou CE, Waltner OG, et al
    IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.
    J Clin Invest. 2024;134:e174184.
    PubMed     Abstract available


    March 2024
  88. MA H, Lu C, Ziegler J, Liu A, et al
    Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.
    J Clin Invest. 2024;134:e180350.
    PubMed    


  89. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2024;134:e167369.
    PubMed     Abstract available


    January 2024
  90. LUO M, Bao L, Xue Y, Zhu M, et al
    ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.
    J Clin Invest. 2024;134:e171166.
    PubMed     Abstract available


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