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Articles published in J Clin Invest

Retrieve available abstracts of 63 articles:
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Single Articles


    August 2022
  1. DULMOVITS BM, Olson TS
    Does immune destruction drive all forms of bone marrow failure?
    J Clin Invest. 2022;132.
    PubMed     Abstract available


    July 2022
  2. EVANS EJ JR, DeGregori J
    Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


  3. JAKUBISON BL, Sarkar T, Gudmundsson KO, Singh S, et al
    ID2 and HIF-1alpha collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


    June 2022
  4. SELLAR RS, Sperling AS, Slabicki M, Gasser JA, et al
    Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells.
    J Clin Invest. 2022 Jun 28. pii: 153514. doi: 10.1172/JCI153514.
    PubMed     Abstract available


  5. FERRARA J, Prado-Acosta M
    Graft-versus-host disease: establishing IL-33 as an important costimulatory molecule.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


  6. LIN Q, Wu L, Chatla S, Chowdhury FA, et al
    Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


  7. GASPARINI SJ, Tessmer K, Reh M, Wieneke S, et al
    Transplanted human cones incorporate into the retina and function in a murine cone degeneration model.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


  8. CASADO JA, Valeri A, Sanchez-Dominguez R, Vela P, et al
    Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia.
    J Clin Invest. 2022 Jun 7. pii: 142842. doi: 10.1172/JCI142842.
    PubMed     Abstract available


  9. WICKS EE, Semenza GL
    Hypoxia-inducible factors: cancer progression and clinical translation.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


  10. LIANG J, Huang G, Liu X, Taghavifar F, et al
    The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


    May 2022
  11. KTENA YP, Koldobskiy MA, Barbato MI, Fu HH, et al
    Donor T-cell DNMT3a regulates alloreactivity in murine models of hematopoietic stem cell transplantation.
    J Clin Invest. 2022 May 24. pii: 158047. doi: 10.1172/JCI158047.
    PubMed     Abstract available


  12. DWYER GK, Mathews LR, Villegas JA, Lucas A, et al
    IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease.
    J Clin Invest. 2022 May 3. pii: 150927. doi: 10.1172/JCI150927.
    PubMed     Abstract available


    February 2022
  13. JIANG L, Hao Y, Shao C, Wu Q, et al
    ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance.
    J Clin Invest. 2022 Feb 8. pii: 143397. doi: 10.1172/JCI143397.
    PubMed     Abstract available


  14. BUTLER PC, Gale EA
    Reversing type 1 diabetes with stem cell-derived islets: a step closer to the dream?
    J Clin Invest. 2022;132.
    PubMed    


  15. SEEBAUER CT, Graus MS, Huang L, McCann A, et al
    Non-beta blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


    January 2022
  16. GUAN Y, Hasipek M, Jiang D, Tiwari AD, et al
    Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.
    J Clin Invest. 2022 Jan 27. pii: 149856. doi: 10.1172/JCI149856.
    PubMed     Abstract available


  17. OLIVA AD, Gupta R, Issa K, Abi Hachem R, et al
    Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.
    J Clin Invest. 2022 Jan 6. pii: 155506. doi: 10.1172/JCI155506.
    PubMed     Abstract available


  18. LI Z, Duan H, Jia Y, Zhao C, et al
    Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
    J Clin Invest. 2022;132.
    PubMed     Abstract available


    November 2021
  19. PERSAUD SP, Ritchey JK, Kim S, Lim S, et al
    Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation.
    J Clin Invest. 2021 Nov 2. pii: 145501. doi: 10.1172/JCI145501.
    PubMed     Abstract available


  20. TOKARZ VL, Delgado-Olguin P, Klip A
    Deprogram and reprogram to solve the riddle of insulin resistance.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  21. BRAEUER RR, Walker NM, Misumi K, Mazzoni-Putman S, et al
    Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    October 2021
  22. CHEN Z, Lu T, Huang L, Wang Z, et al
    Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    August 2021
  23. CHEN Y, Fang S, Ding Q, Jiang R, et al
    ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress.
    J Clin Invest. 2021 Aug 31. pii: e148329. doi: 10.1172/JCI148329.
    PubMed     Abstract available


  24. QIAN J, LeSavage BL, Hubka KM, Ma C, et al
    Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  25. WU K, Kamimoto K, Zhang Y, Yang K, et al
    Basal-epithelial stem cells cross an alarmin checkpoint for post-viral lung disease.
    J Clin Invest. 2021 Aug 10. pii: e149336. doi: 10.1172/JCI149336.
    PubMed     Abstract available


    July 2021
  26. AHN JH, Kim J, Hong SP, Choi SY, et al
    Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    June 2021
  27. SHAIM H, Shanley M, Basar R, Daher M, et al
    Targeting the alphav integrin-TGF-beta axis improves natural killer cell function against glioblastoma stem cells.
    J Clin Invest. 2021 Jun 17. pii: e142116. doi: 10.1172/JCI142116.
    PubMed     Abstract available


  28. TANG XY, Xu L, Wang J, Hong Y, et al
    DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  29. SOCIE G, Kean LS, Zeiser R, Blazar BR, et al
    Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease.
    J Clin Invest. 2021 Jun 8. pii: e149296. doi: 10.1172/JCI149296.
    PubMed     Abstract available


  30. CARTER NM, Pomerantz JL
    Calcineurin inhibitors target Lck activation in graft-versus-host disease.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  31. LOONG JH, Wong TL, Tong M, Sharma R, et al
    Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    April 2021
  32. WANG L, Liu Y, Stratigopoulos G, Panigrahi S, et al
    Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    March 2021
  33. MUSCARELLA AM, Aguirre S, Hao X, Waldvogel SM, et al
    Exploiting bone niches: progression of disseminated tumor cells to metastasis.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  34. OSUKA S, Zhu D, Zhang Z, Li C, et al
    N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    February 2021
  35. FU J, Zuber J, Shonts B, Obradovic A, et al
    Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation.
    J Clin Invest. 2021 Feb 25. pii: 141698. doi: 10.1172/JCI141698.
    PubMed     Abstract available


  36. HE X, Wan J, Yang X, Zhang X, et al
    Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    January 2021
  37. FORTIN J, Bassi C, Ramachandran P, Li WY, et al
    Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.
    J Clin Invest. 2021 Jan 14. pii: 131698. doi: 10.1172/JCI131698.
    PubMed     Abstract available


  38. CAPITANO ML, Mohamad SF, Cooper S, Guo B, et al
    Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  39. GUENANTIN AC, Jebeniani I, Leschik J, Watrin E, et al
    Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  40. UEZUMI A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, et al
    Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


  41. MCGRATH MJ, Eramo MJ, Gurung R, Sriratana A, et al
    Defective lysosome reformation during autophagy causes skeletal muscle disease.
    J Clin Invest. 2021;131.
    PubMed     Abstract available


    December 2020
  42. CONGRAS A, Hoareau-Aveilla C, Caillet N, Tosolini M, et al
    ALK-transformed mature T lymphocytes restore early thymus progenitor features.
    J Clin Invest. 2020;130:6395-6408.
    PubMed     Abstract available


  43. FENG H, Xing W, Han Y, Sun J, et al
    Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.
    J Clin Invest. 2020;130:6354-6365.
    PubMed     Abstract available


    November 2020
  44. DE FRANCO E, Lytrivi M, Ibrahim H, Montaser H, et al
    YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.
    J Clin Invest. 2020 Nov 9. pii: 141455. doi: 10.1172/JCI141455.
    PubMed     Abstract available


  45. PRUDENCIO M, Humphrey J, Pickles S, Brown AL, et al
    Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
    J Clin Invest. 2020;130:6080-6092.
    PubMed     Abstract available


  46. BAIER J, Gansbauer M, Giessler C, Arnold H, et al
    Arginase impedes the resolution of colitis by altering the microbiome and metabolome.
    J Clin Invest. 2020;130:5703-5720.
    PubMed     Abstract available


    October 2020
  47. MO J, Anastasaki C, Chen Z, Shipman T, et al
    Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.
    J Clin Invest. 2020 Oct 27. pii: 139807. doi: 10.1172/JCI139807.
    PubMed     Abstract available


  48. ALMOTIRI A, Alzahrani HAA, Menendez-Gonzalez JB, Abdelfattah A, et al
    Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia.
    J Clin Invest. 2020 Oct 27. pii: 129115. doi: 10.1172/JCI129115.
    PubMed     Abstract available


  49. TIAN Y, Meng L, Wang Y, Li B, et al
    Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction.
    J Clin Invest. 2020 Oct 22. pii: 136774. doi: 10.1172/JCI136774.
    PubMed     Abstract available


  50. SCHULMAN S, El-Darzi E, Florido MH, Friesen M, et al
    A coagulation defect arising from heterozygous premature termination of tissue factor.
    J Clin Invest. 2020;130:5302-5312.
    PubMed     Abstract available


  51. LOVNICKI J, Gan Y, Feng T, Li Y, et al
    LIN28B promotes the development of neuroendocrine prostate cancer.
    J Clin Invest. 2020;130:5338-5348.
    PubMed     Abstract available


  52. MACE EM, Paust S, Conte MI, Baxley RM, et al
    Human NK cell deficiency as a result of biallelic mutations in MCM10.
    J Clin Invest. 2020;130:5272-5286.
    PubMed     Abstract available


    September 2020
  53. BIRESSI S, Filareto A, Rando TA
    Stem cell therapy for muscular dystrophies.
    J Clin Invest. 2020 Sep 18. pii: 142031. doi: 10.1172/JCI142031.
    PubMed     Abstract available


    August 2020
  54. BRINKMEIER ML, Bando H, Camarano AC, Fujio S, et al
    Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors.
    J Clin Invest. 2020;130:4501-4515.
    PubMed     Abstract available


  55. PINZON-GUZMAN C, Sangadala S, Riera KM, Popova EY, et al
    Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.
    J Clin Invest. 2020;130:4396-4410.
    PubMed     Abstract available


    July 2020
  56. HU B, Lv X, Chen H, Xue P, et al
    Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones.
    J Clin Invest. 2020;130:3483-3498.
    PubMed     Abstract available


    June 2020
  57. WACLAWICZEK A, Hamilton A, Rouault-Pierre K, Abarrategi A, et al
    Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia.
    J Clin Invest. 2020;130:3038-3050.
    PubMed     Abstract available


    May 2020
  58. LU H, Xie Y, Tran L, Lan J, et al
    Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness.
    J Clin Invest. 2020 May 19. pii: 138577. doi: 10.1172/JCI138577.
    PubMed     Abstract available


    April 2020
  59. KREUTMAIR S, Erlacher M, Andrieux G, Istvanffy R, et al
    Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
    J Clin Invest. 2020 Apr 27. pii: 126215. doi: 10.1172/JCI126215.
    PubMed     Abstract available


  60. DUTTA R, Zhang TY, Kohnke T, Thomas D, et al
    Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2.
    J Clin Invest. 2020;130:1843-1849.
    PubMed     Abstract available


    March 2020
  61. LI L, Ghorbani M, Weisz-Hubshman M, Rousseau J, et al
    Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
    J Clin Invest. 2020;130:1431-1445.
    PubMed     Abstract available


    January 2020
  62. ASHLEY RJ, Yan H, Wang N, Hale J, et al
    Steroid-resistance in Diamond Blackfan anemia associates with p57Kip2 dysregulation in erythroid progenitors.
    J Clin Invest. 2020 Jan 21. pii: 132284. doi: 10.1172/JCI132284.
    PubMed     Abstract available


    December 2019
  63. OPPEZZO A, Bourseguin J, Renaud E, Pawlikowska P, et al
    Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
    J Clin Invest. 2019 Dec 26. pii: 131540. doi: 10.1172/JCI131540.
    PubMed     Abstract available


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