Retrieve available abstracts of 70 articles: HTML format
Single Articles
October 2025
SINGH B, Hossain MA, Liang XH, Fages J, et al Lnk Deficiency Enhances Translesion Synthesis to Alleviate Replication Stress and
Promote Hematopoietic Stem Cell Fitness.
J Clin Invest. 2025 Oct 30:e191713. doi: 10.1172/JCI191713. PubMedAbstract available
MULLIN C, Lin K, Choe E, Sha C, et al The hematopoietic stem cell MYB enhancer is essential and recurrently amplified
during T-cell leukemogenesis.
J Clin Invest. 2025 Oct 23:e187998. doi: 10.1172/JCI187998. PubMedAbstract available
MEI Y, Xu Y, Zhang X, Feng B, et al 3D cultured human medium spiny neurons functionally integrate and rescue motor
deficits in Huntington's disease mice.
J Clin Invest. 2025;135:e187941. PubMedAbstract available
MO J, Anastasaki C, Chen Z, Shipman T, et al Corrigendum for Humanized neurofibroma model from induced pluripotent stem cells
delineates tumor pathogenesis and developmental origins.
J Clin Invest. 2025;135:e199700. PubMed
WU Z, Li N, Luo Z, Chen Z, et al Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through
sympathetic innervation.
J Clin Invest. 2025;135:e193014. PubMedAbstract available
DUVAL AJ, Seker-Polat F, Rogozinska M, Kinali M, et al SOX9 drives a stem-like transcriptional state and platinum resistance in
high-grade serous ovarian cancer.
J Clin Invest. 2025;135:e186467. PubMedAbstract available
September 2025
PARK SH, Cheon DH, Kim YM, Choi Y, et al NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and
microbiota in murine colitis models.
J Clin Invest. 2025;135:e183093. PubMedAbstract available
JI L, Yan J, Losurdo NA, Wang H, et al Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with
microcephaly.
J Clin Invest. 2025;135:e186119. PubMedAbstract available
YANG J, Jiang Z, Fitzgerald DC, Ma C, et al Retraction of Adult neural stem cells expressing IL-10 confer potent
immunomodulation and remyelination in experimental autoimmune encephalitis.
J Clin Invest. 2025;135:e198608. PubMed
DENG Z, Law CS, Kurra S, Simchoni N, et al Activated STING in the thymic epithelium alters T cell development and selection
leading to autoimmunity.
J Clin Invest. 2025;135:e180252. PubMedAbstract available
ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al Corrigendum to Autophagy differentially regulates tissue tolerance of distinct
target organs in graft-versus-host disease models.
J Clin Invest. 2025;135:e198274. PubMed
August 2025
XU T, Heon-Roberts R, Moore T, Dubot P, et al Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological
mucopolysaccharidoses via brain protein hypersialylation.
J Clin Invest. 2025;135:e177430. PubMedAbstract available
July 2025
SAKA S, Lu Z, Wang Y, Liu P, et al Chromatin factor YY1 controls fetal hematopoietic stem cell migration and
engraftment in mice.
J Clin Invest. 2025 Jul 29:e188140. doi: 10.1172/JCI188140. PubMedAbstract available
SHAO JS, Lai AC, Huang WC, Wu KC, et al Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by
augmenting IL-17A production from ILC3s.
J Clin Invest. 2025 Jul 17:e187372. doi: 10.1172/JCI187372. PubMedAbstract available
SINGH AK, Bernabucci M, Dvorak NM, Haghighijoo Z, et al Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic
neuropathy models.
J Clin Invest. 2025;135:e183749. PubMedAbstract available
HUGHES EP, Syage AR, Mirzaei Mehrabad E, Lane TE, et al OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune
demyelination.
J Clin Invest. 2025;135:e187862. PubMedAbstract available
June 2025
TOMISHIMA SA, Kim DD, Porter N, Guha I, et al The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for
steady-state hematopoiesis in mice.
J Clin Invest. 2025 Jun 26:e180913. doi: 10.1172/JCI180913. PubMedAbstract available
May 2025
D'ADDIO F, Amabile G, Assi E, Maestroni A, et al TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.
J Clin Invest. 2025;135:e185783. PubMedAbstract available
SCHLEGEL N Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial
stem cell defects in inflammatory bowel disease.
J Clin Invest. 2025;135:e192640. PubMedAbstract available
HUANG Y, Xie X, Liu M, Zhang Y, et al Restoring mitochondrial function promotes hematopoietic reconstitution from cord
blood following cryopreservation-related functional decline.
J Clin Invest. 2025;135:e183607. PubMedAbstract available
April 2025
GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in
type 2 diabetes.
J Clin Invest. 2025;135:e183513. PubMedAbstract available
GAO C, Dai Y, Spezza PA, Boasiako P, et al Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to
lower platelet activation.
J Clin Invest. 2025;135:e189801. PubMedAbstract available
KANG M, Choi J, Han J, Araki T, et al Aberrant ERK signaling in astrocytes impairs learning and memory in
RASopathy-associated BRAF mutant mouse models.
J Clin Invest. 2025;135:e176631. PubMedAbstract available
March 2025
DELAFONTAINE S, Meyts I Oncostatin M silence and neopeptide: the value of exploring patients with rare
inherited bone marrow failure.
J Clin Invest. 2025;135:e190955. PubMedAbstract available
February 2025
LI H, Liu P, Xu S, Li Y, et al FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal
aging.
J Clin Invest. 2025;135:e191424. PubMed
WEI W, Gao X, Qian J, Li L, et al Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis
and survival.
J Clin Invest. 2025;135:e177375. PubMedAbstract available
January 2025
HAMAMOTO K, Zhu G, Lai Q, Lesperance J, et al HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription
and HSC dysregulation in NUP98-rearranged leukemia.
J Clin Invest. 2025;135:e184743. PubMedAbstract available
CUI X, Hou L, Yan B, Liu J, et al Sex dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment
via sex-specific Kdm5c/Cxcl12 signaling.
J Clin Invest. 2025 Jan 21:e182125. doi: 10.1172/JCI182125. PubMedAbstract available
GRIFFITH JW, Luster AD No bones about it: regulatory T cells promote fracture healing.
J Clin Invest. 2025;135:e188368. PubMedAbstract available
LI J, Bai J, Pham VT, Hashimoto M, et al Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative
phosphorylation and defective hematopoietic stem cells.
J Clin Invest. 2025 Jan 9:e184069. doi: 10.1172/JCI184069. PubMedAbstract available
CHEN S, Huang C, Li K, Cheng M, et al Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated
macrophages in mice.
J Clin Invest. 2025;135:e180893. PubMedAbstract available
CHEN YT, Jiang MM, Leynes C, Adeyeye M, et al ATRX silences Cartpt expression in osteoblastic cells during skeletal
development.
J Clin Invest. 2025;135:e163587. PubMedAbstract available
CAMPBELL K, Li Q Clonal hematopoiesis JAKs up plaque formation.
J Clin Invest. 2025;135:e187529. PubMedAbstract available
WANG BZ, Morsink MA, Kim SW, Luo LJ, et al Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated
cardiomyopathy.
J Clin Invest. 2025;135:e181630. PubMedAbstract available
December 2024
SAARELA D, Lis P, Gomes S, Nirujogi RS, et al Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical
samples.
J Clin Invest. 2024;135:e183592. PubMedAbstract available
DEFAMIE V, Aliar K, Sarkar S, Vyas F, et al Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in
organoid models of liver injury.
J Clin Invest. 2024;135:e164997. PubMedAbstract available
KIM Y, Kim SW, Saul D, Neyazi M, et al Regulation of sarcomere formation and function in the healthy heart requires a
titin intronic enhancer.
J Clin Invest. 2024;135:e183353. PubMedAbstract available
WU Q, Yu C, Yu F, Guo Y, et al Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven
mTOR pathway in hematopoietic progenitor cells.
J Clin Invest. 2024;134:e173403. PubMedAbstract available
PEACH T, Quattrocelli M The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative
capacity through nutraceuticals.
J Clin Invest. 2024;134:e185054. PubMedAbstract available
WANG Q, Hu T, Zhang Q, Zhang Y, et al Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor
stem cells.
J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595. PubMedAbstract available
November 2024
NAYAK RC, Emberesh S, Trump LR, Wellendorf AM, et al G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing
truncated-neutrophil elastase aggregates.
J Clin Invest. 2024;135:e177342. PubMedAbstract available
WANG S, Huang T, Wu Q, Yuan H, et al Lactate reprograms glioblastoma immunity through CBX3-regulated histone
lactylation.
J Clin Invest. 2024;134:e176851. PubMedAbstract available
ANCEL S, Michaud J, Migliavacca E, Jomard C, et al Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance
regenerative capacity during aging.
J Clin Invest. 2024 Nov 12:e163648. doi: 10.1172/JCI163648. PubMedAbstract available
PALLAVICINI G, Moccia A, Iegiani G, Parolisi R, et al Modeling primary microcephaly with human brain organoids reveals fundamental
roles of CIT kinase activity.
J Clin Invest. 2024;134:e175435. PubMedAbstract available
October 2024
LIU Q, Huang J, Ding H, Tao Y, et al Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models
through its disulfide bond catalytic activity.
J Clin Invest. 2024;134:e177077. PubMedAbstract available
SINHA S, Callow BW, Farfel AP, Roy S, et al Breast cancers that disseminate to bone marrow acquire aggressive phenotypes
through CX43-related tumor-stroma tunnels.
J Clin Invest. 2024;134:e170953. PubMedAbstract available
GHOTBI E, Tchegnon E, Chen Z, Li S, et al Transcription factor KROX20 marks epithelial stem cells for hair follicle
formation.
J Clin Invest. 2024 Oct 3:e180160. doi: 10.1172/JCI180160. PubMedAbstract available
CHEN CL, Tsukamoto H, Liu JC, Kashiwabara C, et al Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
J Clin Invest. 2024;134:e186923. PubMed
September 2024
YANG H, Ping X, Zhou J, Ailifeire H, et al Reversible cold-induced lens opacity in a hibernator reveals a molecular target
for treating cataracts.
J Clin Invest. 2024;134:e169666. PubMedAbstract available
LIU H, Zhao XF, Lu YN, Hayes LR, et al CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of
C9orf72 hexanucleotide repeat RNA.
J Clin Invest. 2024;134:e179016. PubMedAbstract available
DESCHAMPS P, Wacheux M, Gosseye A, Morabito M, et al CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic
myelomonocytic leukemia.
J Clin Invest. 2024;134:e180738. PubMedAbstract available
XING W, Feng H, Jiang B, Gao B, et al Itm2a expression marks periosteal skeletal stem cells that contribute to bone
fracture healing.
J Clin Invest. 2024;134:e176528. PubMedAbstract available
August 2024
BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al Deciphering bone marrow engraftment after allogeneic stem cell transplantation in
humans using single cell analyses.
J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331. PubMedAbstract available
WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of
mesenchymal cells and chronic lung allograft dysfunction.
J Clin Invest. 2024;134:e168393. PubMedAbstract available
SRIDHAR A, DeSantiago J, Chen H, Pavel MA, et al Modulation of NOX2 causes obesity-mediated atrial fibrillation.
J Clin Invest. 2024;134:e175447. PubMedAbstract available
SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al CHIP: a clonal odyssey of the bone marrow niche.
J Clin Invest. 2024;134:e180068. PubMedAbstract available
July 2024
WU K, Zhang Y, Yin-DeClue H, Sun K, et al A correctable immune niche for epithelial stem-cell reprogramming and post-viral
lung diseases.
J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092. PubMedAbstract available
June 2024
MAROM R, Song IW, Busse EC, Washington ME, et al The IFITM5 mutation in osteogenesis imperfecta type V is associated with an
ERK/SOX9-dependent osteoprogenitor differentiation defect.
J Clin Invest. 2024;134:e170369. PubMedAbstract available
May 2024
SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al Susceptibility to innate immune activation in genetically mediated myocarditis.
J Clin Invest. 2024;134:e180254. PubMedAbstract available
SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al Osteochondroprogenitor cells and neutrophils expressing p21 and senescence
markers modulate fracture repair.
J Clin Invest. 2024;134:e179834. PubMedAbstract available
LEOW DM, Ng YK, Wang LC, Koh HW, et al Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver
steatosis in spinal muscular atrophy.
J Clin Invest. 2024;134:e173702. PubMedAbstract available
LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al Generation of allogenic and xenogeneic functional muscle stem cells for
intramuscular transplantation.
J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998. PubMedAbstract available
April 2024
MOE A, Rayasam A, Sauber G, Shah RK, et al Type 2 cannabinoid receptor expression on microglial cells regulates
neuroinflammation during graft versus host disease.
J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205. PubMedAbstract available
SONG X, Tiek D, Miki S, Huang T, et al RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic
targets in adult glioma.
J Clin Invest. 2024;134:e173789. PubMedAbstract available
KEAN LS, Blazar BR Major breakthroughs in hematopoietic stem cell transplantation and future
challenges in clinical implementation.
J Clin Invest. 2024;134:e179944. PubMed
NORTH D, Chakraverty R The road to refractory graft-versus-host disease is paved with good intentions.
J Clin Invest. 2024;134:e177728. PubMedAbstract available
ZHANG P, Fleming P, Andoniou CE, Waltner OG, et al IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone
marrow transplantation.
J Clin Invest. 2024;134:e174184. PubMedAbstract available
March 2024
MA H, Lu C, Ziegler J, Liu A, et al Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and
reduces graft-versus-host disease in mice.
J Clin Invest. 2024;134:e180350. PubMed
ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al Autophagy differentially regulates tissue tolerance of distinct target organs in
graft-versus-host disease models.
J Clin Invest. 2024;134:e167369. PubMedAbstract available
January 2024
LUO M, Bao L, Xue Y, Zhu M, et al ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis
through activation of NRF2.
J Clin Invest. 2024;134:e171166. PubMedAbstract available