Retrieve available abstracts of 53 articles: HTML format
Single Articles
May 2025
D'ADDIO F, Amabile G, Assi E, Maestroni A, et al TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.
J Clin Invest. 2025;135:e185783. PubMedAbstract available
SCHLEGEL N Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial
stem cell defects in inflammatory bowel disease.
J Clin Invest. 2025;135:e192640. PubMedAbstract available
HUANG Y, Xie X, Liu M, Zhang Y, et al Restoring mitochondrial function promotes hematopoietic reconstitution from cord
blood following cryopreservation-related functional decline.
J Clin Invest. 2025;135:e183607. PubMedAbstract available
April 2025
GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in
type 2 diabetes.
J Clin Invest. 2025;135:e183513. PubMedAbstract available
GAO C, Dai Y, Spezza PA, Boasiako P, et al Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to
lower platelet activation.
J Clin Invest. 2025;135:e189801. PubMedAbstract available
KANG M, Choi J, Han J, Araki T, et al Aberrant ERK signaling in astrocytes impairs learning and memory in
RASopathy-associated BRAF mutant mouse models.
J Clin Invest. 2025;135:e176631. PubMedAbstract available
March 2025
DELAFONTAINE S, Meyts I Oncostatin M silence and neopeptide: the value of exploring patients with rare
inherited bone marrow failure.
J Clin Invest. 2025;135:e190955. PubMedAbstract available
February 2025
LI H, Liu P, Xu S, Li Y, et al FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal
aging.
J Clin Invest. 2025;135:e191424. PubMed
WEI W, Gao X, Qian J, Li L, et al Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis
and survival.
J Clin Invest. 2025;135:e177375. PubMedAbstract available
January 2025
HAMAMOTO K, Zhu G, Lai Q, Lesperance J, et al HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription
and HSC dysregulation in NUP98-rearranged leukemia.
J Clin Invest. 2025;135:e184743. PubMedAbstract available
CUI X, Hou L, Yan B, Liu J, et al Sex dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment
via sex-specific Kdm5c/Cxcl12 signaling.
J Clin Invest. 2025 Jan 21:e182125. doi: 10.1172/JCI182125. PubMedAbstract available
GRIFFITH JW, Luster AD No bones about it: regulatory T cells promote fracture healing.
J Clin Invest. 2025;135:e188368. PubMedAbstract available
LI J, Bai J, Pham VT, Hashimoto M, et al Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative
phosphorylation and defective hematopoietic stem cells.
J Clin Invest. 2025 Jan 9:e184069. doi: 10.1172/JCI184069. PubMedAbstract available
CHEN S, Huang C, Li K, Cheng M, et al Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated
macrophages in mice.
J Clin Invest. 2025;135:e180893. PubMedAbstract available
CHEN YT, Jiang MM, Leynes C, Adeyeye M, et al ATRX silences Cartpt expression in osteoblastic cells during skeletal
development.
J Clin Invest. 2025;135:e163587. PubMedAbstract available
CAMPBELL K, Li Q Clonal hematopoiesis JAKs up plaque formation.
J Clin Invest. 2025;135:e187529. PubMedAbstract available
WANG BZ, Morsink MA, Kim SW, Luo LJ, et al Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated
cardiomyopathy.
J Clin Invest. 2025;135:e181630. PubMedAbstract available
December 2024
SAARELA D, Lis P, Gomes S, Nirujogi RS, et al Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical
samples.
J Clin Invest. 2024;135:e183592. PubMedAbstract available
DEFAMIE V, Aliar K, Sarkar S, Vyas F, et al Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in
organoid models of liver injury.
J Clin Invest. 2024;135:e164997. PubMedAbstract available
KIM Y, Kim SW, Saul D, Neyazi M, et al Regulation of sarcomere formation and function in the healthy heart requires a
titin intronic enhancer.
J Clin Invest. 2024;135:e183353. PubMedAbstract available
WU Q, Yu C, Yu F, Guo Y, et al Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven
mTOR pathway in hematopoietic progenitor cells.
J Clin Invest. 2024;134:e173403. PubMedAbstract available
PEACH T, Quattrocelli M The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative
capacity through nutraceuticals.
J Clin Invest. 2024;134:e185054. PubMedAbstract available
WANG Q, Hu T, Zhang Q, Zhang Y, et al Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor
stem cells.
J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595. PubMedAbstract available
November 2024
NAYAK RC, Emberesh S, Trump LR, Wellendorf AM, et al G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing
truncated-neutrophil elastase aggregates.
J Clin Invest. 2024;135:e177342. PubMedAbstract available
WANG S, Huang T, Wu Q, Yuan H, et al Lactate reprograms glioblastoma immunity through CBX3-regulated histone
lactylation.
J Clin Invest. 2024;134:e176851. PubMedAbstract available
ANCEL S, Michaud J, Migliavacca E, Jomard C, et al Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance
regenerative capacity during aging.
J Clin Invest. 2024 Nov 12:e163648. doi: 10.1172/JCI163648. PubMedAbstract available
PALLAVICINI G, Moccia A, Iegiani G, Parolisi R, et al Modeling primary microcephaly with human brain organoids reveals fundamental
roles of CIT kinase activity.
J Clin Invest. 2024;134:e175435. PubMedAbstract available
October 2024
LIU Q, Huang J, Ding H, Tao Y, et al Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models
through its disulfide bond catalytic activity.
J Clin Invest. 2024;134:e177077. PubMedAbstract available
SINHA S, Callow BW, Farfel AP, Roy S, et al Breast cancers that disseminate to bone marrow acquire aggressive phenotypes
through CX43-related tumor-stroma tunnels.
J Clin Invest. 2024;134:e170953. PubMedAbstract available
GHOTBI E, Tchegnon E, Chen Z, Li S, et al Transcription factor KROX20 marks epithelial stem cells for hair follicle
formation.
J Clin Invest. 2024 Oct 3:e180160. doi: 10.1172/JCI180160. PubMedAbstract available
CHEN CL, Tsukamoto H, Liu JC, Kashiwabara C, et al Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
J Clin Invest. 2024;134:e186923. PubMed
September 2024
YANG H, Ping X, Zhou J, Ailifeire H, et al Reversible cold-induced lens opacity in a hibernator reveals a molecular target
for treating cataracts.
J Clin Invest. 2024;134:e169666. PubMedAbstract available
LIU H, Zhao XF, Lu YN, Hayes LR, et al CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of
C9orf72 hexanucleotide repeat RNA.
J Clin Invest. 2024;134:e179016. PubMedAbstract available
DESCHAMPS P, Wacheux M, Gosseye A, Morabito M, et al CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic
myelomonocytic leukemia.
J Clin Invest. 2024;134:e180738. PubMedAbstract available
XING W, Feng H, Jiang B, Gao B, et al Itm2a expression marks periosteal skeletal stem cells that contribute to bone
fracture healing.
J Clin Invest. 2024;134:e176528. PubMedAbstract available
August 2024
BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al Deciphering bone marrow engraftment after allogeneic stem cell transplantation in
humans using single cell analyses.
J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331. PubMedAbstract available
WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of
mesenchymal cells and chronic lung allograft dysfunction.
J Clin Invest. 2024;134:e168393. PubMedAbstract available
SRIDHAR A, DeSantiago J, Chen H, Pavel MA, et al Modulation of NOX2 causes obesity-mediated atrial fibrillation.
J Clin Invest. 2024;134:e175447. PubMedAbstract available
SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al CHIP: a clonal odyssey of the bone marrow niche.
J Clin Invest. 2024;134:e180068. PubMedAbstract available
July 2024
WU K, Zhang Y, Yin-DeClue H, Sun K, et al A correctable immune niche for epithelial stem-cell reprogramming and post-viral
lung diseases.
J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092. PubMedAbstract available
June 2024
MAROM R, Song IW, Busse EC, Washington ME, et al The IFITM5 mutation in osteogenesis imperfecta type V is associated with an
ERK/SOX9-dependent osteoprogenitor differentiation defect.
J Clin Invest. 2024;134:e170369. PubMedAbstract available
May 2024
SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al Susceptibility to innate immune activation in genetically mediated myocarditis.
J Clin Invest. 2024;134:e180254. PubMedAbstract available
SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al Osteochondroprogenitor cells and neutrophils expressing p21 and senescence
markers modulate fracture repair.
J Clin Invest. 2024;134:e179834. PubMedAbstract available
LEOW DM, Ng YK, Wang LC, Koh HW, et al Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver
steatosis in spinal muscular atrophy.
J Clin Invest. 2024;134:e173702. PubMedAbstract available
LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al Generation of allogenic and xenogeneic functional muscle stem cells for
intramuscular transplantation.
J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998. PubMedAbstract available
April 2024
MOE A, Rayasam A, Sauber G, Shah RK, et al Type 2 cannabinoid receptor expression on microglial cells regulates
neuroinflammation during graft versus host disease.
J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205. PubMedAbstract available
SONG X, Tiek D, Miki S, Huang T, et al RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic
targets in adult glioma.
J Clin Invest. 2024;134:e173789. PubMedAbstract available
KEAN LS, Blazar BR Major breakthroughs in hematopoietic stem cell transplantation and future
challenges in clinical implementation.
J Clin Invest. 2024;134:e179944. PubMed
NORTH D, Chakraverty R The road to refractory graft-versus-host disease is paved with good intentions.
J Clin Invest. 2024;134:e177728. PubMedAbstract available
ZHANG P, Fleming P, Andoniou CE, Waltner OG, et al IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone
marrow transplantation.
J Clin Invest. 2024;134:e174184. PubMedAbstract available
March 2024
MA H, Lu C, Ziegler J, Liu A, et al Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and
reduces graft-versus-host disease in mice.
J Clin Invest. 2024;134:e180350. PubMed
ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al Autophagy differentially regulates tissue tolerance of distinct target organs in
graft-versus-host disease models.
J Clin Invest. 2024;134:e167369. PubMedAbstract available
January 2024
LUO M, Bao L, Xue Y, Zhu M, et al ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis
through activation of NRF2.
J Clin Invest. 2024;134:e171166. PubMedAbstract available