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Articles published in Lancet Neurol

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Single Articles


    June 2022
  1. BAAK LM, Wagenaar N, van der Aa NE, Groenendaal F, et al
    Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study.
    Lancet Neurol. 2022;21:528-536.
    PubMed     Abstract available


  2. GONZALEZ F, Ferriero DM
    Stem cells for perinatal stroke.
    Lancet Neurol. 2022;21:497-499.
    PubMed    


  3. THE LANCET NEUROLOGY
    No area of stroke research should be left behind.
    Lancet Neurol. 2022;21:495.
    PubMed    


    May 2022
  4. ROTHWELL PM
    20 years of improvement in stroke care: the rewards from finally funding more research.
    Lancet Neurol. 2022;21:402-404.
    PubMed    


    April 2022
  5. BIVARD A, Zhao H, Churilov L, Campbell BCV, et al
    Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open-label trial.
    Lancet Neurol. 2022 Apr 29. pii: S1474-4422(22)00171.
    PubMed     Abstract available


  6. KVISTAD CE, Naess H, Helleberg BH, Idicula T, et al
    Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint, non-inferiority trial.
    Lancet Neurol. 2022 Apr 29. pii: S1474-4422(22)00124.
    PubMed     Abstract available


  7. COUTTS SB, Yu AYX
    Tenecteplase for acute stroke: the thrombolysis puzzle.
    Lancet Neurol. 2022 Apr 29. pii: S1474-4422(22)00172.
    PubMed    


  8. HILL G, Regan S, Francis R
    Research priorities to improve stroke outcomes.
    Lancet Neurol. 2022;21:312-313.
    PubMed    


    March 2022
  9. BONATI LH, Jansen O, de Borst GJ, Brown MM, et al
    Management of atherosclerotic extracranial carotid artery stenosis.
    Lancet Neurol. 2022;21:273-283.
    PubMed     Abstract available


    February 2022
  10. ZHAO J, Yuan F, Song C, Yin R, et al
    Safety and efficacy of three enteral feeding strategies in patients with severe stroke in China (OPENS): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.
    Lancet Neurol. 2022 Feb 24. pii: S1474-4422(22)00010.
    PubMed     Abstract available


  11. DZIEWAS R
    Nutrition in acute stroke management: food for thought.
    Lancet Neurol. 2022 Feb 24. pii: S1474-4422(22)00078.
    PubMed    


  12. GUTIERREZ J, Turan TN, Hoh BL, Chimowitz MI, et al
    Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment.
    Lancet Neurol. 2022 Feb 7. pii: S1474-4422(21)00376.
    PubMed     Abstract available


  13. SAMARASEKERA U
    Jeyaraj Pandian: passionate about improving stroke care in India.
    Lancet Neurol. 2022;21:120.
    PubMed    


    January 2022
  14. BAILLIEUL S, Dekkers M, Brill AK, Schmidt MH, et al
    Sleep apnoea and ischaemic stroke: current knowledge and future directions.
    Lancet Neurol. 2022;21:78-88.
    PubMed     Abstract available


  15. PUY L, Cordonnier C
    Stroke research in 2021: insights into the reorganisation of stroke care.
    Lancet Neurol. 2022;21:2-3.
    PubMed    


    December 2021
  16. FEIGIN VL
    Primary stroke prevention: useful thresholds?
    Lancet Neurol. 2021 Dec 16. pii: S1474-4422(21)00458.
    PubMed    


    November 2021
  17. SCHREUDER FHBM, van Nieuwenhuizen KM, Hofmeijer J, Vermeer SE, et al
    Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF): a randomised, open-label, phase 2 trial.
    Lancet Neurol. 2021;20:907-916.
    PubMed     Abstract available


    September 2021
  18. PANDIAN JD, Sebastian IA
    Integrated approach to stroke burden: are we doing enough?
    Lancet Neurol. 2021 Sep 3. pii: S1474-4422(21)00287.
    PubMed    



  19. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
    Lancet Neurol. 2021 Sep 3. pii: S1474-4422(21)00252.
    PubMed     Abstract available


  20. CASO V, Mosconi MG
    Lessons to be learned in intracerebral haemorrhage research.
    Lancet Neurol. 2021 Sep 2. pii: S1474-4422(21)00296.
    PubMed    


  21. HOWARD DPJ, Rothwell PM
    Asymptomatic carotid stenosis and stroke risk - Authors' reply.
    Lancet Neurol. 2021;20:699.
    PubMed    


  22. ABBOTT A
    Asymptomatic carotid stenosis and stroke risk.
    Lancet Neurol. 2021;20:698-699.
    PubMed    


  23. ROTHWELL PM, Buchan AM
    A new thrombolytic drug for acute ischaemic stroke.
    Lancet Neurol. 2021;20:687-689.
    PubMed    


  24. GUSEV EI, Martynov MY, Nikonov AA, Shamalov NA, et al
    Non-immunogenic recombinant staphylokinase versus alteplase for patients with acute ischaemic stroke 4.5 h after symptom onset in Russia (FRIDA): a randomised, open label, multicentre, parallel-group, non-inferiority trial.
    Lancet Neurol. 2021;20:721-728.
    PubMed     Abstract available


    July 2021
  25. BANDINI F, Vestito L, Filippi L
    Prehospital scales in acute ischaemic stroke management.
    Lancet Neurol. 2021;20:504.
    PubMed    


  26. DUVEKOT MHC, Venema E, Kerkhoff H, Dippel DWJ, et al
    Prehospital scales in acute ischaemic stroke management - Authors' reply.
    Lancet Neurol. 2021;20:504-505.
    PubMed    


    June 2021
  27. LI L, Poon MTC, Samarasekera NE, Perry LA, et al
    Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies.
    Lancet Neurol. 2021;20:437-447.
    PubMed     Abstract available


  28. HAEUSLER KG, Kirchhof P, Kunze C, Tutuncu S, et al
    Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study.
    Lancet Neurol. 2021;20:426-436.
    PubMed     Abstract available


  29. CHENG X, Dong Q
    Towards individualised secondary prevention after intracerebral haemorrhage.
    Lancet Neurol. 2021;20:411-413.
    PubMed    


  30. WASSERLAUF J, Volgman AS
    Monitoring for atrial fibrillation after stroke.
    Lancet Neurol. 2021;20:410-411.
    PubMed    


    May 2021
  31. SAMARASEKERA U
    Michael Moskowitz: solving the puzzle of migraine.
    Lancet Neurol. 2021 May 17. pii: S1474-4422(21)00141.
    PubMed    


  32. JORDAN LC, DeBaun MR, Donahue MJ
    Advances in neuroimaging to improve care in sickle cell disease.
    Lancet Neurol. 2021;20:398-408.
    PubMed     Abstract available


  33. HACHINSKI V, Avan A, Gilliland J, Oveisgharan S, et al
    A new definition of brain health.
    Lancet Neurol. 2021;20:335-336.
    PubMed    


    April 2021
  34. WEAVER NA, Kuijf HJ, Aben HP, Abrigo J, et al
    Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
    Lancet Neurol. 2021 Apr 23. pii: S1474-4422(21)00060.
    PubMed     Abstract available


  35. PANTONI L, Salvadori E
    Location of infarcts and post-stroke cognitive impairment.
    Lancet Neurol. 2021 Apr 23. pii: S1474-4422(21)00107.
    PubMed    


  36. BEST JG, Ambler G, Wilson D, Lee KJ, et al
    Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from
    Lancet Neurol. 2021;20:294-303.
    PubMed     Abstract available


  37. GREENBERG SM
    Cerebral microbleeds and prediction of intracranial haemorrhage.
    Lancet Neurol. 2021;20:252-254.
    PubMed    


  38. ZIAI WC, Al-Kawaz M
    Blood pressure management after endovascular therapy.
    Lancet Neurol. 2021;20:248-249.
    PubMed    


  39. LAUMANN TO, Ortega M, Hoyt CR, Seider NA, et al
    Brain network reorganisation in an adolescent after bilateral perinatal strokes.
    Lancet Neurol. 2021;20:255-256.
    PubMed    


    March 2021
  40. SCHMIDT R, Hofer E
    Identifying novel genetic risk loci for lacunar stroke.
    Lancet Neurol. 2021 Mar 25. pii: S1474-4422(21)00099.
    PubMed    


  41. TRAYLOR M, Persyn E, Tomppo L, Klasson S, et al
    Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
    Lancet Neurol. 2021 Mar 25. pii: S1474-4422(21)00031.
    PubMed     Abstract available


  42. ENGELTER ST, Traenka C, Gensicke H, Schaedelin SA, et al
    Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial.
    Lancet Neurol. 2021 Mar 22. pii: S1474-4422(21)00044.
    PubMed     Abstract available


  43. HOWARD DPJ, Gaziano L, Rothwell PM
    Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.
    Lancet Neurol. 2021;20:193-202.
    PubMed     Abstract available


  44. VAN DIJCK JTJM, Kompanje EJO, Nederkoorn PJ, Peul WC, et al
    Advanced consent for acute stroke trials - Authors' reply.
    Lancet Neurol. 2021;20:170-171.
    PubMed    


  45. SHAMY M, Dewar B, Niznick N, Nicholls S, et al
    Advanced consent for acute stroke trials.
    Lancet Neurol. 2021;20:170.
    PubMed    


  46. SPENCE JD
    Treatment of asymptomatic carotid stenosis.
    Lancet Neurol. 2021;20:163-165.
    PubMed    


    February 2021
  47. MAZIGHI M, Richard S, Lapergue B, Sibon I, et al
    Safety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial.
    Lancet Neurol. 2021 Feb 26. pii: S1474-4422(20)30483.
    PubMed     Abstract available


    January 2021
  48. DUVEKOT MHC, Venema E, Rozeman AD, Moudrous W, et al
    Comparison of eight prehospital stroke scales to detect intracranial large-vessel occlusion in suspected stroke (PRESTO): a prospective observational study.
    Lancet Neurol. 2021 Jan 7. pii: S1474-4422(20)30439.
    PubMed     Abstract available


  49. GOYAL M, Marko M
    Optimising prehospital stroke triage in a changing landscape.
    Lancet Neurol. 2021 Jan 7. pii: S1474-4422(20)30488.
    PubMed    


  50. TSIVGOULIS G, Katsanos AH
    Important advances in stroke research in 2020.
    Lancet Neurol. 2021;20:2-3.
    PubMed    


    December 2020
  51. WU S, Anderson CS
    Healthy eating for secondary stroke prevention.
    Lancet Neurol. 2020 Dec 18. pii: S1474-4422(20)30450.
    PubMed    


  52. ENGLISH C, MacDonald-Wicks L, Patterson A, Attia J, et al
    The role of diet in secondary stroke prevention.
    Lancet Neurol. 2020 Dec 18. pii: S1474-4422(20)30433.
    PubMed     Abstract available


  53. SILBERGLEIT R, Dickert NW
    Context and principles must drive alternatives to consent in emergency research.
    Lancet Neurol. 2020;19:968-969.
    PubMed    


    November 2020
  54. THE LANCET NEUROLOGY
    A unified European action plan on stroke.
    Lancet Neurol. 2020 Nov 6. pii: S1474-4422(20)30409.
    PubMed    


    October 2020
  55. MERETOJA A, Yassi N, Wu TY, Churilov L, et al
    Tranexamic acid in patients with intracerebral haemorrhage (STOP-AUST): a multicentre, randomised, placebo-controlled, phase 2 trial.
    Lancet Neurol. 2020 Oct 28. pii: S1474-4422(20)30369.
    PubMed     Abstract available


  56. KOMPANJE EJO, van Dijck JTJM, Chalos V, van den Berg SA, et al
    Informed consent procedures for emergency interventional research in patients with traumatic brain injury and ischaemic stroke.
    Lancet Neurol. 2020 Oct 21. pii: S1474-4422(20)30276.
    PubMed     Abstract available


    September 2020
  57. FIFI JT, Mocco J
    COVID-19 related stroke in young individuals.
    Lancet Neurol. 2020;19:713-715.
    PubMed    


    August 2020

  58. Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial.
    Lancet Neurol. 2020;19:661-669.
    PubMed     Abstract available



  59. Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial.
    Lancet Neurol. 2020;19:651-660.
    PubMed     Abstract available


  60. KWAKKEL G, Meskers C, Ward NS
    Time for the next stage of stroke recovery trials.
    Lancet Neurol. 2020;19:636-637.
    PubMed    


    July 2020
  61. FASSBENDER K, Walter S, Grunwald IQ, Merzou F, et al
    Prehospital stroke management in the thrombectomy era.
    Lancet Neurol. 2020;19:601-610.
    PubMed     Abstract available


  62. MOHR JP, Overbey JR, Hartmann A, Kummer RV, et al
    Medical management with interventional therapy versus medical management alone for unruptured brain arteriovenous malformations (ARUBA): final follow-up of a multicentre, non-blinded, randomised controlled trial.
    Lancet Neurol. 2020;19:573-581.
    PubMed     Abstract available


    May 2020
  63. HURFORD R, Wolters FJ, Li L, Lau KK, et al
    Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study.
    Lancet Neurol. 2020;19:413-421.
    PubMed     Abstract available


  64. HERMANN DM, Bassetti CL, Marx U, Audoli-Inthavong ML, et al
    Refining endpoints for stroke recovery trials.
    Lancet Neurol. 2020;19:381-382.
    PubMed    


  65. UCHIYAMA S
    Intensive medical management of intracranial arterial stenosis.
    Lancet Neurol. 2020;19:371-373.
    PubMed    


  66. THE LANCET NEUROLOGY
    The fight against stroke must go on.
    Lancet Neurol. 2020;19:369.
    PubMed    


  67. MORGAN J
    Werner Hacke: a new era for stroke patients.
    Lancet Neurol. 2020;19:387.
    PubMed    


    March 2020
  68. CHABRIAT H, Bassetti CL, Marx U, Audoli-Inthavong ML, et al
    Safety and efficacy of GABAA alpha5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial.
    Lancet Neurol. 2020;19:226-233.
    PubMed     Abstract available


  69. CRAMER SC
    Issues important to the design of stroke recovery trials.
    Lancet Neurol. 2020;19:197-198.
    PubMed    


  70. GOYAL M, Ospel J
    Challenges to stroke care 5 years after endovascular therapy became the standard.
    Lancet Neurol. 2020;19:210-211.
    PubMed    


    January 2020
  71. STINEAR CM, Lang CE, Zeiler S, Byblow WD, et al
    Advances and challenges in stroke rehabilitation.
    Lancet Neurol. 2020 Jan 28. pii: S1474-4422(19)30415.
    PubMed     Abstract available


  72. WU S, Cheng Y, Wu B, Liu M, et al
    Stroke research in 2019: towards optimising treatment and prevention.
    Lancet Neurol. 2020;19:2-3.
    PubMed    


    December 2019
  73. SCHONEWILLE WJ
    BEST evidence on mechanical thrombectomy for patients with vertebrobasilar occlusion.
    Lancet Neurol. 2019 Dec 9. pii: S1474-4422(19)30477.
    PubMed    


  74. LIU X, Dai Q, Ye R, Zi W, et al
    Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial.
    Lancet Neurol. 2019 Dec 9. pii: S1474-4422(19)30395.
    PubMed     Abstract available


    November 2019
  75. AHMADI M, Laumeier I, Ihl T, Steinicke M, et al
    A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial.
    Lancet Neurol. 2019 Nov 7. pii: S1474-4422(19)30369.
    PubMed     Abstract available


  76. LI L
    Support programme for secondary prevention of stroke: inspiration to continue?
    Lancet Neurol. 2019 Nov 7. pii: S1474-4422(19)30410.
    PubMed    


  77. BAYONA-ORTIZ H, Useche JN, Yanez N, Velasco SC, et al
    Availability of stroke units in Colombia.
    Lancet Neurol. 2019;18:988.
    PubMed    


    October 2019
  78. THE LANCET NEUROLOGY
    Global prevention of stroke: focus on the individual?
    Lancet Neurol. 2019;18:903.
    PubMed    


    September 2019
  79. FLOEL A
    Computerised speech and language therapy in post-stroke aphasia.
    Lancet Neurol. 2019;18:806-807.
    PubMed    


  80. PALMER R, Dimairo M, Cooper C, Enderby P, et al
    Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS): a multicentre, single-blinded, randomised controlled trial.
    Lancet Neurol. 2019;18:821-833.
    PubMed     Abstract available


    July 2019
  81. SAPOSNIK G, Hachinski V
    The pathway towards an effective reduction of stroke burden worldwide: teamwork.
    Lancet Neurol. 2019;18:622-623.
    PubMed    


    June 2019
  82. HILL MD, Benavente OR
    The uncertain role for phosphodiesterase inhibitors in stroke prevention.
    Lancet Neurol. 2019;18:515-517.
    PubMed    


  83. STINEAR CM
    Dopamine for motor recovery after stroke: where to from here?
    Lancet Neurol. 2019;18:514-515.
    PubMed    


  84. FORD GA, Bhakta BB, Cozens A, Hartley S, et al
    Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial.
    Lancet Neurol. 2019;18:530-538.
    PubMed     Abstract available


  85. THE LANCET NEUROLOGY
    Adding stroke to the political agenda in Europe.
    Lancet Neurol. 2019;18:513.
    PubMed    


    May 2019
  86. TSIVGOULIS G, Katsanos AH
    Can cerebral microbleeds predict stroke recurrence?
    Lancet Neurol. 2019 May 22. pii: S1474-4422(19)30194.
    PubMed    


  87. CHRISTENSEN H
    Antiplatelets after intracerebral haemorrhage: treat the patient, not the brain imaging.
    Lancet Neurol. 2019 May 21. pii: S1474-4422(19)30189.
    PubMed    


    April 2019
  88. DICHGANS M, Pulit SL, Rosand J
    Stroke genetics: discovery, biology, and clinical applications.
    Lancet Neurol. 2019 Apr 8. pii: S1474-4422(19)30043.
    PubMed     Abstract available


  89. BRAININ M
    Stroke epidemiology in China: which are the next steps?
    Lancet Neurol. 2019;18:325-326.
    PubMed    


  90. WU S, Wu B, Liu M, Chen Z, et al
    Stroke in China: advances and challenges in epidemiology, prevention, and management.
    Lancet Neurol. 2019;18:394-405.
    PubMed     Abstract available


    March 2019

  91. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
    Lancet Neurol. 2019 Mar 11. pii: S1474-4422(19)30034.
    PubMed     Abstract available


  92. GORELICK PB
    The global burden of stroke: persistent and disabling.
    Lancet Neurol. 2019 Mar 11. pii: S1474-4422(19)30030.
    PubMed    


  93. MELIS M, Ricci S, Toni D
    Optimal stroke prevention in patients with PFO.
    Lancet Neurol. 2019;18:231.
    PubMed    


  94. DICHGANS M
    Dementia risk after transient ischaemic attack and stroke.
    Lancet Neurol. 2019;18:223-225.
    PubMed    


  95. HANKEY GJ
    Prasugrel or clopidogrel for long-term secondary stroke prevention?
    Lancet Neurol. 2019;18:222-223.
    PubMed    


  96. PENDLEBURY ST, Rothwell PM
    Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study.
    Lancet Neurol. 2019;18:248-258.
    PubMed     Abstract available


    January 2019
  97. WARDLAW JM, Bath PM
    Stroke research in 2018: extended time windows, refined benefit, and lifestyle prevention targets.
    Lancet Neurol. 2019;18:2-3.
    PubMed    


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