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Articles published in Lancet

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    April 2024

  1. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a sys
    Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757.
    PubMed     Abstract available

  2. GE Z, Kan J, Gao X, Raza A, et al
    Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial.
    Lancet. 2024 Apr 5:S0140-6736(24)00473-2. doi: 10.1016/S0140-6736(24)00473.
    PubMed     Abstract available

  3. PARK SJ, Ahn JM, Kang DY, Yun SC, et al
    Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial.
    Lancet. 2024 Apr 4:S0140-6736(24)00413-6. doi: 10.1016/S0140-6736(24)00413.
    PubMed     Abstract available

  4. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
    Lancet. 2024 Apr 3:S0140-6736(24)00367-2. doi: 10.1016/S0140-6736(24)00367.
    PubMed     Abstract available

    March 2024
  5. VAHL TP, Thourani VH, Makkar RR, Hamid N, et al
    Transcatheter aortic valve implantation in patients with high-risk symptomatic native aortic regurgitation (ALIGN-AR): a prospective, multicentre, single-arm study.
    Lancet. 2024 Mar 26:S0140-6736(23)02806-4. doi: 10.1016/S0140-6736(23)02806.
    PubMed     Abstract available

  6. MELLO A, Stehr D, Bujarski K, Duchaine B, et al
    Visualising facial distortions in prosopometamorphopsia.
    Lancet. 2024;403:1176.

  7. Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021.
    Lancet. 2024 Mar 19:S0140-6736(24)00550-6. doi: 10.1016/S0140-6736(24)00550.
    PubMed     Abstract available

  8. CHEN WG, Edwards E, Iyengar S, Finkelstein R, et al
    Music and medicine: quickening the tempo of progress.
    Lancet. 2024 Mar 18:S0140-6736(24)00477-X. doi: 10.1016/S0140-6736(24)00477.

  9. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950-2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden
    Lancet. 2024 Mar 8:S0140-6736(24)00476-8. doi: 10.1016/S0140-6736(24)00476.
    PubMed     Abstract available

    February 2024
  10. CONSOLI A, Gory B
    Long-term results of mechanical thrombectomy for large ischaemic stroke.
    Lancet. 2024 Feb 8:S0140-6736(24)00158-2. doi: 10.1016/S0140-6736(24)00158.

  11. SARRAJ A, Abraham MG, Hassan AE, Blackburn S, et al
    Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial.
    Lancet. 2024 Feb 8:S0140-6736(24)00050-3. doi: 10.1016/S0140-6736(24)00050.
    PubMed     Abstract available

    January 2024
  12. BEN-SHLOMO Y, Darweesh S, Llibre-Guerra J, Marras C, et al
    The epidemiology of Parkinson's disease.
    Lancet. 2024;403:283-292.
    PubMed     Abstract available

    November 2023
  13. FROST R, Avgerinou C, Kalwarowsky S, Mahmood F, et al
    Enabling health and maintaining independence for older people at home (HomeHealth trial): a multicentre randomised controlled trial.
    Lancet. 2023;402 Suppl 1:S42.
    PubMed     Abstract available

  14. BARRADO-MARTIN Y, Frost R, Catchpole J, Rookes T, et al
    Goal setting as part of a holistic intervention to promote independence in older people with mild frailty: a process evaluation alongside a randomised controlled trial.
    Lancet. 2023;402 Suppl 1:S1.
    PubMed     Abstract available

  15. LIU L, Li X, Marshall IJ, Bhalla A, et al
    Trajectories of depressive symptoms 10 years after stroke and associated risk factors: a prospective cohort study.
    Lancet. 2023;402 Suppl 1:S64.
    PubMed     Abstract available

    October 2023
  16. MESSERLI FH, Bangalore S, Mandrola JM
    beta blockers switched to first-line therapy in hypertension.
    Lancet. 2023 Oct 13:S0140-6736(23)01733-6. doi: 10.1016/S0140-6736(23)01733.
    PubMed     Abstract available

  17. DIPPEL DWJ, Roozenbeek B
    Thrombectomy for acute ischaemic stroke without advanced imaging.
    Lancet. 2023 Oct 10:S0140-6736(23)02229-8. doi: 10.1016/S0140-6736(23)02229.

  18. BENDSZUS M, Fiehler J, Subtil F, Bonekamp S, et al
    Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial.
    Lancet. 2023 Oct 10:S0140-6736(23)02032-9. doi: 10.1016/S0140-6736(23)02032.
    PubMed     Abstract available

    August 2023
  19. MAKKAR RR, Kapadia S, Chakravarty T, Cubeddu RJ, et al
    Outcomes of repeat transcatheter aortic valve replacement with balloon-expandable valves: a registry study.
    Lancet. 2023 Aug 31:S0140-6736(23)01636-7. doi: 10.1016/S0140-6736(23)01636.
    PubMed     Abstract available

  20. MAJOIE CB, Cavalcante F, Gralla J, Yang P, et al
    Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials.
    Lancet. 2023 Aug 25:S0140-6736(23)01142-X. doi: 10.1016/S0140-6736(23)01142.
    PubMed     Abstract available

    Does thrombolysis add value to thrombectomy for acute ischaemic stroke?
    Lancet. 2023 Aug 25:S0140-6736(23)01202-3. doi: 10.1016/S0140-6736(23)01202.

  22. WILKOFF BL, Filippatos G, Leclercq C, Gold MR, et al
    Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial.
    Lancet. 2023 Aug 24:S0140-6736(23)00912-1. doi: 10.1016/S0140-6736(23)00912.
    PubMed     Abstract available

    July 2023
  23. STRANDELL A, Hellgren M
    Time to stop routine prescription of low-molecular-weight heparin to women with recurrent pregnancy loss and inherited thrombophilia.
    Lancet. 2023;402:6-7.

    June 2023
  24. HUANG C, Huang L, Wang Y, Li X, et al
    6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.
    Lancet. 2023 Jun 12:S0140-6736(23)00810-3. doi: 10.1016/S0140-6736(23)00810.
    PubMed     Abstract available

    May 2023
  25. MA L, Hu X, Song L, Chen X, et al
    The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial.
    Lancet. 2023 May 24:S0140-6736(23)00806-1. doi: 10.1016/S0140-6736(23)00806.
    PubMed     Abstract available

    April 2023
    Even more benefit with endovascular treatment for patients with acute ischaemic stroke: MR CLEAN-LATE.
    Lancet. 2023;401:1317-1319.

  27. HAWKEY C
    Helicobacter pylori eradication and aspirin: a puzzle yet to be solved - Author's reply.
    Lancet. 2023;401:1266.

  28. GATTA L, Zullo A, Vaira D
    Helicobacter pylori eradication and aspirin: a puzzle yet to be solved.
    Lancet. 2023;401:1265-1266.

  29. LI Y, Liang Z, Stone GW, Han Y, et al
    BRIGHT-4 trial: bivalirudin strikes back - Authors' reply.
    Lancet. 2023;401:1158.

  30. PIRIOU PG, Manigold T, Letocart V, Guerin P, et al
    BRIGHT-4 trial: bivalirudin strikes back.
    Lancet. 2023;401:1157-1158.

    March 2023
  31. OLTHUIS SGH, Pirson FAV, Pinckaers FME, Hinsenveld WH, et al
    Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase
    Lancet. 2023 Mar 29:S0140-6736(23)00575-5. doi: 10.1016/S0140-6736(23)00575.
    PubMed     Abstract available

  32. KLOK FA, Siegerink B
    Ordinal outcomes add value to clinical trials.
    Lancet. 2023;401:995.

  33. HE J, Ouyang N, Guo X, Sun G, et al
    Effectiveness of a non-physician community health-care provider-led intensive blood pressure intervention versus usual care on cardiovascular disease (CRHCP): an open-label, blinded-endpoint, cluster-randomised trial.
    Lancet. 2023 Mar 2:S0140-6736(22)02603-4. doi: 10.1016/S0140-6736(22)02603.
    PubMed     Abstract available

    February 2023
  34. WANG Y, Li S, Pan Y, Li H, et al
    Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial.
    Lancet. 2023 Feb 8:S0140-6736(22)02600-9. doi: 10.1016/S0140-6736(22)02600.
    PubMed     Abstract available

  35. MENON BK, Singh N, Sylaja PN
    Tenecteplase use in patients with acute ischaemic stroke.
    Lancet. 2023 Feb 8:S0140-6736(22)02633-2. doi: 10.1016/S0140-6736(22)02633.

    January 2023
  36. WERRING DJ, Banerjee G
    Convexity subarachnoid haemorrhage.
    Lancet. 2023;401:193-194.

    November 2022

  37. Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial.
    Lancet. 2022;400:1693-1703.
    PubMed     Abstract available

  38. YANG P, Song L, Zhang Y, Zhang X, et al
    Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial.
    Lancet. 2022;400:1585-1596.
    PubMed     Abstract available

  39. MISTRY EA, Nguyen TN
    Blood pressure goals after mechanical thrombectomy: a moving target.
    Lancet. 2022;400:1558-1559.

    October 2022
  40. BISTERVELS IM, Buchmuller A, Wiegers HMG, Ni Ainle F, et al
    Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial.
    Lancet. 2022 Oct 28. pii: S0140-6736(22)02128.
    PubMed     Abstract available

  41. MACKENZIE IS, Hawkey CJ, Ford I, Greenlaw N, et al
    Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.
    Lancet. 2022;400:1195-1205.
    PubMed     Abstract available

    September 2022
  42. SHOAMANESH A, Mundl H, Smith EE, Masjuan J, et al
    Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial.
    Lancet. 2022 Sep 2. pii: S0140-6736(22)01588.
    PubMed     Abstract available

  43. DIENER HC, Rothwell PM
    Antithrombotic drugs in secondary stroke prevention: still some way to go.
    Lancet. 2022 Sep 2. pii: S0140-6736(22)01703.

    July 2022
  44. MACSWEENEY S, Subramanian G, Podlasek A, Auer D, et al
    Urgent need to update NICE guidelines on imaging for transient ischaemic attack.
    Lancet. 2022 Jul 12. pii: S0140-6736(22)01281.

  45. KHATRI P
    Intravenous thrombolysis before thrombectomy for acute ischaemic stroke.
    Lancet. 2022;400:76-78.

  46. MITCHELL PJ, Yan B, Churilov L, Dowling RJ, et al
    Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial.
    Lancet. 2022;400:116-125.
    PubMed     Abstract available

  47. FISCHER U, Kaesmacher J, Strbian D, Eker O, et al
    Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial.
    Lancet. 2022;400:104-115.
    PubMed     Abstract available

    June 2022
  48. SANDSET EC, Tsvigoulis G
    Tenecteplase for acute ischaemic stroke.
    Lancet. 2022 Jun 28. pii: S0140-6736(22)01107.

  49. MENON BK, Buck BH, Singh N, Deschaintre Y, et al
    Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial.
    Lancet. 2022 Jun 28. pii: S0140-6736(22)01054.
    PubMed     Abstract available

    May 2022
  50. DELGADO-LISTA J, Alcala-Diaz JF, Torres-Pena JD, Quintana-Navarro GM, et al
    Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial.
    Lancet. 2022 May 4. pii: S0140-6736(22)00122.
    PubMed     Abstract available

    April 2022
  51. PICCINI JP, Caso V, Connolly SJ, Fox KAA, et al
    Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study.
    Lancet. 2022;399:1383-1390.
    PubMed     Abstract available

    March 2022

  52. Progress in health among regions of Ethiopia, 1990-2019: a subnational country analysis for the Global Burden of Disease Study 2019.
    Lancet. 2022 Mar 11. pii: S0140-6736(21)02868.
    PubMed     Abstract available

    February 2022
  53. ALMEKHLAFI MA, Coutts SB
    Anti-thrombotics cause harm in the setting of stroke thrombectomy.
    Lancet. 2022 Feb 28. pii: S0140-6736(22)00335.

  54. VAN DER STEEN W, van de Graaf RA, Chalos V, Lingsma HF, et al
    Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial.
    Lancet. 2022 Feb 28. pii: S0140-6736(22)00014.
    PubMed     Abstract available

    January 2022
  55. SHAH SJ, Borlaug BA, Chung ES, Cutlip DE, et al
    Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial.
    Lancet. 2022 Jan 31. pii: S0140-6736(22)00016.
    PubMed     Abstract available

    November 2021
  56. JOVIN TG, Nogueira RG, Lansberg MG, Demchuk AM, et al
    Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
    Lancet. 2021 Nov 11. pii: S0140-6736(21)01341.
    PubMed     Abstract available

  57. DIPPEL D, Roozenbeek B
    Late thrombectomy for ischaemic stroke.
    Lancet. 2021 Nov 11. pii: S0140-6736(21)02097.

    October 2021
  58. KIM CJ, Park MW, Kim MC, Choo EH, et al
    Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised tr
    Lancet. 2021;398:1305-1316.
    PubMed     Abstract available

    September 2021
  59. TULAMO R, Venermo M
    Intervention for asymptomatic carotid artery stenosis.
    Lancet. 2021;398:1025-1027.

    August 2021
  60. SVENNBERG E, Friberg L, Frykman V, Al-Khalili F, et al
    Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01637.
    PubMed     Abstract available

  61. HALLIDAY A, Bulbulia R, Bonati LH, Chester J, et al
    Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01910.
    PubMed     Abstract available

  62. JOSEPH P, Roshandel G, Gao P, Pais P, et al
    Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01827.
    PubMed     Abstract available

  63. FREEDMAN B, Lowres N
    High-intensity atrial fibrillation screening to prevent stroke.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01785.

  64. LOWRES N, Freedman B
    Population screening for atrial fibrillation to prevent stroke.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01750.

  65. SVENDSEN JH, Diederichsen SZ, Hojberg S, Krieger DW, et al
    Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01698.
    PubMed     Abstract available

  66. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis.
    Lancet. 2021 Aug 26. pii: S0140-6736(21)01921.
    PubMed     Abstract available

  67. BURKART KG, Brauer M, Aravkin AY, Godwin WW, et al
    Estimating the cause-specific relative risks of non-optimal temperature on daily mortality: a two-part modelling approach applied to the Global Burden of Disease Study.
    Lancet. 2021;398:685-697.
    PubMed     Abstract available

    July 2021
  68. KATSOULARIS I, Fonseca-Rodriguez O, Farrington P, Lindmark K, et al
    Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study.
    Lancet. 2021 Jul 29. pii: S0140-6736(21)00896.
    PubMed     Abstract available

  69. MAFHAM M, Baigent C
    What is the association of COVID-19 with heart attacks and strokes?
    Lancet. 2021 Jul 29. pii: S0140-6736(21)01071.

    May 2021
  70. KOO BK, Kang J, Park KW, Rhee TM, et al
    Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial.
    Lancet. 2021 May 14. pii: S0140-6736(21)01063.
    PubMed     Abstract available

  71. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis.
    Lancet. 2021;397:1625-1636.
    PubMed     Abstract available

    April 2021
  72. VAN DER MEIJ A, Wermer MJH
    Vagus nerve stimulation: a potential new treatment for ischaemic stroke.
    Lancet. 2021;397:1520-1521.

  73. DAWSON J, Liu CY, Francisco GE, Cramer SC, et al
    Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.
    Lancet. 2021;397:1545-1553.
    PubMed     Abstract available

  74. GALLI M, Benenati S, Capodanno D, Franchi F, et al
    Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
    Lancet. 2021;397:1470-1483.
    PubMed     Abstract available

  75. BAYAS A, Menacher M, Christ M, Behrens L, et al
    Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination.
    Lancet. 2021 Apr 14. pii: S0140-6736(21)00872.

    March 2021
  76. TUNA MA, Rothwell PM
    Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis.
    Lancet. 2021;397:902-912.
    PubMed     Abstract available

    February 2021
  77. BENJAMIN LA, Phiri T, Simister R, Solomon T, et al
    Recognising HIV infection in systems of care for stroke.
    Lancet. 2021;397:794.

  78. PANDIAN JD, Kalkonde Y, Sebastian IA, Bosch J, et al
    Recognising HIV infection in systems of care for stroke - Authors' reply.
    Lancet. 2021;397:794-795.

  79. LANGLEY RE, Gilbert DC, Duong T, Clarke NW, et al
    Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme.
    Lancet. 2021;397:581-591.
    PubMed     Abstract available

    December 2020
  80. SCOTT IU, Campochiaro PA, Newman NJ, Biousse V, et al
    Retinal vascular occlusions.
    Lancet. 2020;396:1927-1940.
    PubMed     Abstract available

    November 2020
  81. GENCER B, Marston NA, Im K, Cannon CP, et al
    Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials.
    Lancet. 2020;396:1637-1643.
    PubMed     Abstract available

  82. THOMALLA G, Boutitie F, Ma H, Koga M, et al
    Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data.
    Lancet. 2020 Nov 6. pii: S0140-6736(20)32163.
    PubMed     Abstract available

    October 2020
  83. PANDIAN JD, Kalkonde Y, Sebastian IA, Felix C, et al
    Stroke systems of care in low-income and middle-income countries: challenges and opportunities.
    Lancet. 2020;396:1443-1451.
    PubMed     Abstract available

  84. LANGHORNE P, Audebert HJ, Cadilhac DA, Kim J, et al
    Stroke systems of care in high-income countries: what is optimal?
    Lancet. 2020;396:1433-1442.
    PubMed     Abstract available

    September 2020

  85. NCD Countdown 2030: pathways to achieving Sustainable Development Goal target 3.4.
    Lancet. 2020;396:918-934.
    PubMed     Abstract available

  86. MAKKAR RR, Cheng W, Waksman R, Satler LF, et al
    Self-expanding intra-annular versus commercially available transcatheter heart valves in high and extreme risk patients with severe aortic stenosis (PORTICO IDE): a randomised, controlled, non-inferiority trial.
    Lancet. 2020;396:669-683.
    PubMed     Abstract available

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