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90‑sec video • 4‑min audio • paper abstracts

This week, 27 April 2025:

  1. Treatment-resistant hypertension
  2. Influenza transmission
  3. Nanoplastics in human brains
  4. Malaria elimination
  5. Chikungunya vaccine

  Stroke

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31.03.2025

1 Am Heart J
4 BMC Neurol
1 BMJ
5 BMJ Open
2 Circ Cardiovasc Imaging
2 Circ Cardiovasc Interv
1 Circ Cardiovasc Qual Outcomes
2 Circ Genom Precis Med
1 Circ Heart Fail
1 Circulation
1 Cochrane Database Syst Rev
2 Crit Care Med
1 Eur Heart J
1 Eur J Vasc Endovasc Surg
1 Heart
4 Int J Cardiol
1 Int J Stroke
2 J Am Geriatr Soc
1 J Neuroeng Rehabil
1 J Stroke Cerebrovasc Dis
1 J Vasc Surg
1 JAMA
1 JAMA Neurol
2 Lancet Neurol
2 Neurol Clin Pract
2 Neurology
1 Phys Ther
9 PLoS One
21 Stroke


  Retrieve available abstracts of this week’s articles:
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Single Articles


    Am Heart J

  1. ZEYMER U, Hassinger F, Bramlage P, Schafer A, et al
    Hyperoxemic Oxygen Therapy in Patients with Acute Anterior Myocardial Infarction: HOT-AAMI - Design and Rationale of a Randomized Trial.
    Am Heart J. 2025 Mar 21:S0002-8703(25)00095-X. doi: 10.1016/j.ahj.2025.
    PubMed         Abstract available


    BMC Neurol

  2. CHEN R, Liu Z, Liao R, Liang H, et al
    The effect of sarcopenia on prognosis in patients with mild acute ischemic stroke: a prospective cohort study.
    BMC Neurol. 2025;25:130.
    PubMed         Abstract available

  3. JIA DM, Li X, Zhang BC, Zhang BR, et al
    Therapeutic efficacy of repetitive transcranial magnetic stimulation on gait and limb balance function in patients with lower limb dysfunction post-cerebral infarction: a systematic review and meta-analysis.
    BMC Neurol. 2025;25:126.
    PubMed         Abstract available

  4. ADEMOYEGUN AB, Awotidebe TO, Odetunde MO, Inaolaji SO, et al
    Effects of very early exercise on inflammatory markers and clinical outcomes in patients with ischaemic stroke- a randomized controlled trial.
    BMC Neurol. 2025;25:121.
    PubMed         Abstract available

  5. HEEGERS A, Rakers SE, van Twillert S, Moulaert VRM, et al
    Social Cognitive Treatment (T-ScEmo) for Various Neurological Patient Groups: Study Rationale and Protocol for a Randomized Control Trial (T-ScEmo4ALL).
    BMC Neurol. 2025;25:129.
    PubMed         Abstract available


    BMJ

  6. JURASCHEK SP, Hu JR, Cluett JL, Mita C, et al
    Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis.
    BMJ. 2025;388:e080507.
    PubMed         Abstract available


    BMJ Open

  7. BAIG SS, Mooney C, McKendrick K, Duffy KEM, et al
    TRanscutaneous lImb reCovEry Post-Stroke (TRICEPS): study protocol for a randomised, controlled, multiarm, multistage adaptive design trial.
    BMJ Open. 2025;15:e092520.
    PubMed         Abstract available

  8. PAN X, Du W, Liu Z
    Poor clinical outcome despite successful recanalisation in patients with acute myocardial infarction undergoing direct percutaneous coronary intervention: a retrospective cohort study.
    BMJ Open. 2025;15:e097434.
    PubMed         Abstract available


  9. Correction: Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial.
    BMJ Open. 2025;15:e091059corr2.
    PubMed        

  10. DAVIES A, Chapman S, Mullin S, Bakhbakhi D, et al
    Qualitative study exploring the barriers and facilitators to low-dose aspirin adherence in pregnant women with placental dysfunction risk in the UK.
    BMJ Open. 2025;15:e093888.
    PubMed         Abstract available

  11. ZHANG R, Hong J, Zheng X, Chen S, et al
    Effects of poststroke heart rate variability on the neurological impairment severity and the prognosis among patients with ischaemic stroke: a scoping review.
    BMJ Open. 2025;15:e092826.
    PubMed         Abstract available


    Circ Cardiovasc Imaging

  12. MOON I, Lee J, Lee SA, Jeong D, et al
    Artificial Intelligence-Enhanced Analysis of Echocardiography-Based Radiomic Features for Myocardial Hypertrophy Detection and Etiology Differentiation.
    Circ Cardiovasc Imaging. 2025 Mar 27:e017436.
    PubMed         Abstract available

  13. SANTIAGUEL S, Schoeneberg L, Hu J, Huddleston C, et al
    Is 4D CMR Sufficient for Preoperative Planning?
    Circ Cardiovasc Imaging. 2025 Mar 26:e017802.
    PubMed        


    Circ Cardiovasc Interv

  14. DEL PORTILLO JH, Cepas-Guillen P, Kalavrouziotis D, Dumont E, et al
    Transcarotid Versus Surgical Aortic Valve Replacement for the Treatment of Severe Aortic Stenosis.
    Circ Cardiovasc Interv. 2025 Mar 26:e014928.
    PubMed         Abstract available

  15. SCHNEIDER DJ, McMahon SR, Angiolillo DJ, Fanaroff AC, et al
    Predictive Value of Platelet FcgammaRIIa in Patients Treated With PCI Compared With Medical Therapy Alone After Myocardial Infarction.
    Circ Cardiovasc Interv. 2025 Mar 26:e014939.
    PubMed         Abstract available


    Circ Cardiovasc Qual Outcomes

  16. GROVES CC, Damush TM, Myers LJ, Baye F, et al
    Enhancing Stroke Awareness and Activation Among High-Risk Populations: A Randomized Direct Mail Intervention in Diverse Healthcare Settings.
    Circ Cardiovasc Qual Outcomes. 2025 Mar 24:e011425.
    PubMed         Abstract available


    Circ Genom Precis Med

  17. NADERIAN M, Hamed ME, Vaseem AA, Norland K, et al
    Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events.
    Circ Genom Precis Med. 2025 Mar 28:e004968. doi: 10.1161/CIRCGEN.124.004968.
    PubMed         Abstract available

  18. LUXAMA JW, Knowles JW
    Many Journeys Originating at the Same Source to Arrive at Solutions to the Common Problem of High Lipoprotein(a).
    Circ Genom Precis Med. 2025 Mar 25:e005126. doi: 10.1161/CIRCGEN.125.005126.
    PubMed        


    Circ Heart Fail

  19. MONTALTO C, Savonitto S
    Transfusions in Heart Failure and Acute Myocardial Infarction: Novel Data Begets New Questions.
    Circ Heart Fail. 2025 Mar 26:e012877. doi: 10.1161/CIRCHEARTFAILURE.125.012877.
    PubMed        


    Circulation

  20. NIIRANEN TJ, Schnabel RB, Schutte AE, Biton Y, et al
    Hypertension and Atrial Fibrillation: A Frontier Review From the AF-SCREEN International Collaboration.
    Circulation. 2025;151:863-877.
    PubMed         Abstract available


    Cochrane Database Syst Rev

  21. STRAUSS SA, Ma GW, Seo C, Siracuse JJ, et al
    Ultrasound-guided versus anatomic landmark-guided percutaneous femoral artery access.
    Cochrane Database Syst Rev. 2025;3:CD014594.
    PubMed         Abstract available


    Crit Care Med

  22. DONOHUE C, Raye K, Pandharipande P, Dittus RS, et al
    A Systematic Review of the Prevalence and Characteristics of Oropharyngeal Dysphagia in Critically Ill Patients During the Acute and Postacute Recovery Phase.
    Crit Care Med. 2025 Mar 27. doi: 10.1097/CCM.0000000000006669.
    PubMed         Abstract available

  23. EHRENZELLER S, Klompas M
    Associations Between Prophylactic IV Antibiotics and Outcomes in Patients With Acute Severe Brain Injury Who Require Mechanical Ventilation: Systematic Review and Meta-Analysis.
    Crit Care Med. 2025 Mar 28. doi: 10.1097/CCM.0000000000006654.
    PubMed         Abstract available


    Eur Heart J

  24. KANG D, Choi KH
    Less harmful alternative for smoking: addressing concerns on the observational study of electronic cigarettes and cardiovascular outcomes.
    Eur Heart J. 2025 Mar 25:ehaf153. doi: 10.1093.
    PubMed        


    Eur J Vasc Endovasc Surg

  25. NANA P, Haulon S, Tsilimparis N, Le Houerou T, et al
    Fenestrated or Branched Endovascular Aortic Arch Repair Outcomes in Female Patients: A Retrospective Multicentre Analysis.
    Eur J Vasc Endovasc Surg. 2025 Mar 22:S1078-5884(25)00254.
    PubMed         Abstract available


    Heart

  26. SEVER PS, Rostamian S, Whiteley W, Ariti C, et al
    Long-term benefits of atorvastatin on the incidence of cardiovascular events: the ASCOT-Legacy 20-year follow-up.
    Heart. 2025 Mar 26:heartjnl-2024-325104. doi: 10.1136/heartjnl-2024-325104.
    PubMed         Abstract available


    Int J Cardiol

  27. GAO S, Li D, Qiao B, Gong Y, et al
    Association of elevated levels of soluble transferrin receptor with left ventricular remodeling and mortality in patients with heart failure: Evidence from observational and genetic investigations.
    Int J Cardiol. 2025 Mar 6:133133. doi: 10.1016/j.ijcard.2025.133133.
    PubMed         Abstract available

  28. STRACQUALURSI M, Nemola G, Santangelo G, Moscardelli S, et al
    Monitoring SGLT2 inhibition effectiveness on pulmonary systolic pressure in heart failure with reduced ejection fraction.
    Int J Cardiol. 2025;428:133136.
    PubMed         Abstract available

  29. PALM CL, de Wit S, Gorter TM, Rienstra M, et al
    Beyond the gut: Systemic levels of short-chain fatty acids are altered in patients with heart failure.
    Int J Cardiol. 2025;428:133124.
    PubMed         Abstract available

  30. YANG L, Yuan Z, Chen Y, Zeng Y, et al
    Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis.
    Int J Cardiol. 2025 Mar 24:133202. doi: 10.1016/j.ijcard.2025.133202.
    PubMed         Abstract available


    Int J Stroke

  31. JING X, Nogueira R, Nguyen TN, Tao C, et al
    Endovascular Treatment in Acute Intracranial Distal Medium Vessel Occlusion Stroke: Study Protocol and Rationale.
    Int J Stroke. 2025 Mar 25:17474930251332753. doi: 10.1177/17474930251332753.
    PubMed         Abstract available


    J Am Geriatr Soc

  32. CHEN Y, James BD, Capuano AW, Banerjee M, et al
    The Association of Dementia and Mild Cognitive Impairment With Outpatient Ambulatory Care Utilization in the Community.
    J Am Geriatr Soc. 2025 Mar 22. doi: 10.1111/jgs.19446.
    PubMed         Abstract available

  33. AHMED M, Ahsan A, Shafiq A, Hashmi TM, et al
    Invasive Versus Conservative Treatment Strategy in Older Patients With Non-ST Segment Elevation Acute Coronary Syndromes: A Meta-Analysis of Randomized Controlled Trials.
    J Am Geriatr Soc. 2025 Mar 26. doi: 10.1111/jgs.19447.
    PubMed         Abstract available


    J Neuroeng Rehabil

  34. BUTET S, Fleury M, Duche Q, Bannier E, et al
    EEG-fMRI neurofeedback versus motor imagery after stroke, a randomized controlled trial.
    J Neuroeng Rehabil. 2025;22:67.
    PubMed         Abstract available


    J Stroke Cerebrovasc Dis

  35. QURESHI AI, Bhatti IA, Gillani SA, Fakih R, et al
    Factors and Outcomes Associated with National Institutes of Health Stroke Scale Scores in Acute Ischemic Stroke Patients Undergoing Thrombectomy in United States.
    J Stroke Cerebrovasc Dis. 2025 Mar 21:108292.
    PubMed         Abstract available


    J Vasc Surg

  36. COLLINS V, Adler LSF, Geller JE, Hamilton C, et al
    Carotid Endarterectomy is Less Expensive than Transcarotid Artery Revascularization.
    J Vasc Surg. 2025 Mar 24:S0741-5214(25)00626-3. doi: 10.1016/j.jvs.2025.
    PubMed         Abstract available


    JAMA

  37. KHAN F, Yogendrakumar V, Lun R, Ganesh A, et al
    Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis.
    JAMA. 2025 Mar 26:e252033. doi: 10.1001/jama.2025.2033.
    PubMed         Abstract available


    JAMA Neurol

  38. SHEFNER JM, Cudkowicz ME, Genge A, Hardiman O, et al
    Reldesemtiv in Amyotrophic Lateral Sclerosis: Results From the COURAGE-ALS Randomized Clinical Trial.
    JAMA Neurol. 2025 Mar 24:e250241. doi: 10.1001/jamaneurol.2025.0241.
    PubMed         Abstract available


    Lancet Neurol

  39. CAVALCANTE F, Treurniet K, Kaesmacher J, Kappelhof M, et al
    Intravenous thrombolysis before endovascular treatment versus endovascular treatment alone for patients with large vessel occlusion and carotid tandem lesions: individual participant data meta-analysis of six randomised trials.
    Lancet Neurol. 2025;24:305-315.
    PubMed         Abstract available

  40. SALMAN RA, Thrippleton MJ
    Pharmacological therapy for cerebral cavernous malformations.
    Lancet Neurol. 2025;24:276-277.
    PubMed        


    Neurol Clin Pract

  41. SUN S, Lomachinsky V, Smith LH, Newhouse JP, et al
    Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke.
    Neurol Clin Pract. 2025;15:e200452.
    PubMed         Abstract available

  42. KENNELLY M, Webb AJ, Ack SE, Kwak GH, et al
    Practice-Pattern Variation in Neurocritical Care Blood Pressure Control Reveals Opportunities for Improved Long-Term Hypertension Control.
    Neurol Clin Pract. 2025;15:e200453.
    PubMed         Abstract available


    Neurology

  43. POLINENI S, Polineni P, Santos D, Daniel D, et al
    Associations Between Measures of Structural Racism and Acute Ischemic Stroke Incidence in the United States.
    Neurology. 2025;104:e213413.
    PubMed         Abstract available

  44. YAQUB A, Bis JC, Frenzel S, Koini M, et al
    Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies.
    Neurology. 2025;104:e213421.
    PubMed         Abstract available


    Phys Ther

  45. MILLER T, Ouyang H, Tsang CSL, Calderon-Juarez M, et al
    Motor Impairment and Disuse Are Independent Predictors of Vascular Outcomes Poststroke.
    Phys Ther. 2025;105:pzaf002.
    PubMed         Abstract available


    PLoS One

  46. ZHOU Y, Yang Q, Zhou Z, Yang X, et al
    Systemic immune-inflammation index is associated with clinical outcome of acute ischemic stroke patients after intravenous thrombolysis treatment.
    PLoS One. 2025;20:e0319920.
    PubMed         Abstract available

  47. LI C, Liu Y, Mao H, Yang W, et al
    Oncosis is the predominant type of cell death in rhabdomyolysis following exertional heat stroke.
    PLoS One. 2025;20:e0308586.
    PubMed         Abstract available

  48. WANG L, Wang H, Wang Y, Wang Y, et al
    Effect of different concentrations of heparin-locking solution for central venous catheters in hemodialysis patients: A systematic review and meta-analysis.
    PLoS One. 2025;20:e0320207.
    PubMed         Abstract available

  49. KODANI Y, Nagami S, Yokozeki A, Fukunaga S, et al
    Current status of Tele-speech language therapy by type and support for patients with post-stroke aphasia: A scoping review.
    PLoS One. 2025;20:e0319805.
    PubMed         Abstract available

  50. LIU F, Jones AYM, Tsang RCC, Yam TTT, et al
    Effects of inspiratory muscle training on respiratory function, diaphragmatic thickness, balance control, exercise capacity and quality of life in people after stroke: A randomized controlled trial protocol.
    PLoS One. 2025;20:e0319899.
    PubMed         Abstract available

  51. WHITE DAE, Jewett M, Burns M, Rodriguez C, et al
    A quality improvement initiative to increase HIV post-exposure prophylaxis treatment for emergency department patients after sexual assault: A pre-post study.
    PLoS One. 2025;20:e0320690.
    PubMed         Abstract available

  52. BENDER L, Sichtermann T, Dorn C, Minkenberg J, et al
    Exploring Aachen minipigs as in vivo model for human intracranial studies: Focus on hind limb artery diameters.
    PLoS One. 2025;20:e0320606.
    PubMed         Abstract available

  53. ZHANG W, Lin H, Zhu Z, Zhu K, et al
    Epsin bioactive coating reduced in-stent intimal hyperplasia by promoting early phase reendothelialization and inhibiting smooth muscle cell proliferation.
    PLoS One. 2025;20:e0318019.
    PubMed         Abstract available

  54. KATONA A, von Koch S, Andell P, Volz S, et al
    Long-term prognosis after coronary bifurcation PCI-A nationwide observational study.
    PLoS One. 2025;20:e0317628.
    PubMed         Abstract available


    Stroke

  55. STAESSENS S, Vandelanotte S, Francois O, Boulleaux E, et al
    Association Between Thrombus Composition and Etiology in Patients With Acute Ischemic Stroke Treated by Thrombectomy.
    Stroke. 2025;56:1026-1035.
    PubMed         Abstract available

  56. CADILHAC DA, Birhanu MM, Churilov L, Zhao H, et al
    Costs and Benefits of the Melbourne Mobile Stroke Unit Compared With Standard Ambulance: Causal Analysis Using Observational Linked Data.
    Stroke. 2025;56:948-956.
    PubMed         Abstract available

  57. SINGH N, Bala F, Ademola A, Almekhlafi M, et al
    Safety, Functional Disability, Healthcare Utilization, and Quality-of-Life Outcomes in Elderly Receiving Alteplase and Tenecteplase: A Secondary Analysis From the AcT Trial.
    Stroke. 2025 Mar 24. doi: 10.1161/STROKEAHA.124.049512.
    PubMed         Abstract available

  58. MAILLARD A, Pipiras E, Jarnoux P, Aloui C, et al
    Identity-by-Descent Analysis Uncovering a Founder Event in a Novel Hereditary Small Vessel Cerebral Disease.
    Stroke. 2025 Mar 24. doi: 10.1161/STROKEAHA.124.049839.
    PubMed         Abstract available

  59. SAPKOTA S, Maillard P, Stickel AM, Tarraf W, et al
    Multimodal Associations of Modifiable Risk Factors on White Matter Injury: The SOL-INCA-MRI Study (HCHS/SOL).
    Stroke. 2025 Mar 24. doi: 10.1161/STROKEAHA.124.049904.
    PubMed         Abstract available

  60. SHAWKAT A, Barreto AD, Broderick JP, Derdeyn CP, et al
    Comparison of Local and Centrally Adjudicated Modified Rankin Scale Scores in the MOST Trial.
    Stroke. 2025 Mar 24. doi: 10.1161/STROKEAHA.124.049825.
    PubMed         Abstract available

  61. PENSATO U, Demchuk AM, Donnan GA
    Submaximal Angioplasty for Severe Intracranial Atherosclerotic Stenosis: Benefit of Revascularization at Last.
    Stroke. 2025;56:e114-e118.
    PubMed         Abstract available

  62. XU H, Yang Y, Zhou Q, Huo R, et al
    Map3k3 (I441M) Knock-In Mouse Model of Cerebral Cavernous Malformations.
    Stroke. 2025;56:1010-1025.
    PubMed         Abstract available

  63. FANDLER-HOFLER S, Murthy SB
    Hematoma Expansion in Intracerebral Hemorrhage: Time Is the Enemy.
    Stroke. 2025;56:848-849.
    PubMed        

  64. HEITKAMP C, Flottmann F, Faizy TD, Heitkamp A, et al
    General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke.
    Stroke. 2025 Mar 25. doi: 10.1161/STROKEAHA.124.049358.
    PubMed         Abstract available

  65. KNIEP H, Gellissen S, Thomalla G, Bendszus M, et al
    Thrombectomy With Low ASPECTS: The Roles of Infarct Volume and Postacute Neurological Status.
    Stroke. 2025 Mar 25. doi: 10.1161/STROKEAHA.124.050052.
    PubMed         Abstract available

  66. FILCHENKO I, Eberhard-Moscicka AK, Picard JL, Schmidt MH, et al
    Thalamic Stroke and Sleep Study: Sleep-Wake, Autonomic Regulation, and Cognition.
    Stroke. 2025 Mar 26. doi: 10.1161/STROKEAHA.124.049156.
    PubMed         Abstract available

  67. KOJIMA N, Koido M, He Y, Shimmori Y, et al
    Recurrent Stroke Prediction by Applying a Stroke Polygenic Risk Score in the Japanese Population.
    Stroke. 2025 Mar 26. doi: 10.1161/STROKEAHA.124.047786.
    PubMed         Abstract available

  68. MANDEL DM, Shu L, Chang C, Jack N, et al
    Factors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection.
    Stroke. 2025 Mar 27. doi: 10.1161/STROKEAHA.124.048215.
    PubMed         Abstract available

  69. RAYMOND J, Darsaut TE, Saleme S, Rouchaud A, et al
    Transvenous Approach for the Treatment of Cerebral Arteriovenous Malformations: A Randomized Comparison With Transarterial Embolization.
    Stroke. 2025 Mar 27. doi: 10.1161/STROKEAHA.124.049109.
    PubMed         Abstract available

  70. ULLMAN N, Vossough A, Beslow LA, Ichord R, et al
    FLAIR Vascular Hyperintensities as Imaging Biomarker in Pediatric Acute Ischemic Stroke.
    Stroke. 2025 Mar 28. doi: 10.1161/STROKEAHA.124.048717.
    PubMed         Abstract available

  71. YOGENDRAKUMAR V, Campbell BCV, Johns H, Churilov L, et al
    Association of Ischemic Core Hypodensity With Thrombectomy Treatment Effect in Large Core Stroke: A Secondary Analysis of the SELECT2 Randomized Controlled Trial.
    Stroke. 2025 Mar 28. doi: 10.1161/STROKEAHA.124.048899.
    PubMed         Abstract available

  72. KHAWAR H, McFarlane S, Libman RB
    Stroke Mimics at 30 Years: Where We Have Been, Where We Are Now, and Where We Are Going.
    Stroke. 2025 Jan 13. doi: 10.1161/STROKEAHA.124.048067.
    PubMed         Abstract available

  73. AYKAN SA, Lai JH, Sugimoto K, Aykan O, et al
    Impaired Resting-State Functional Connectivity in Cerebral Autosomal-Dominant Arteriopathy, Subcortical Infarcts, and Leukoencephalopathy Mutant Mice.
    Stroke. 2025;56:987-995.
    PubMed         Abstract available

  74. PEARCEY GEP, Barry AJ, Sandhu MS, Carroll TJ, et al
    Acute Intermittent Hypoxia in People Living With Chronic Stroke: A Case Series.
    Stroke. 2025 Feb 25. doi: 10.1161/STROKEAHA.124.046620.
    PubMed         Abstract available

  75. RAFAEL-PATINO J, Fischi-Gomez E, Madrona A, Ravano V, et al
    Diffusion Imaging Protocol Heterogeneity Biases Ischemic Core Volume, Location, and Clinical Associations in Acute Stroke.
    Stroke. 2025;56:915-925.
    PubMed         Abstract available


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