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	Explore this week’s CC Journal Club 90‑sec video • 4‑min audio • paper abstracts This week, 27 April 2025: Treatment-resistant hypertension Influenza transmission Nanoplastics in human brains Malaria elimination Chikungunya vaccine

Stroke

Free Subscription 28.04.2025 1 Am Heart J 1 Am J Cardiol 1 Am J Emerg Med 1 Ann Intern Med 1 Ann Neurol 1 BMC Neurol 1 Cerebrovasc Dis 1 Circ Cardiovasc Interv 1 Circ Cardiovasc Qual Outcomes 1 Circ Heart Fail 2 Circulation 1 Cochrane Database Syst Rev 1 Eur Heart J 3 Int J Stroke 5 J Neuroeng Rehabil 4 J Stroke Cerebrovasc Dis 1 JAMA Neurol 2 Lancet Neurol 2 Neurology 6 PLoS One 11 Stroke 1 World Neurosurg

Retrieve available abstracts of this week’s articles: HTML format

Single Articles

Am Heart J

1. DILLINGER JG, Pezel T, Batias L, Angoulvant D, et al
   Twice-a-day administration of aspirin in patients with diabetes mellitus or aspirin resistance after acute coronary syndrome: Rationale and design of the randomized ANDAMAN trial.
   Am Heart J. 2025 Apr 21:S0002-8703(25)00132-2. doi: 10.1016/j.ahj.2025.
   PubMed         Abstract available
   
   

   
   Am J Cardiol

2. REICHL JJ, Poljo A, Stolte T, Schmitt R, et al
   Association of Body Mass Index with Procedural Success and Outcomes in Patients undergoing Transcatheter Aortic Valve Implantation.
   Am J Cardiol. 2025 Apr 19:S0002-9149(25)00257.
   PubMed         Abstract available
   
   

   
   Am J Emerg Med

3. WILLIAMS K, Hayes L, Negrete A, Marjoncu D, et al
   Impact of antihypertensive administration strategy on time to thrombolysis in acute ischemic stroke.
   Am J Emerg Med. 2025;94:10-14.
   PubMed         Abstract available
   
   

   
   Ann Intern Med

4. ABDEL-QADIR H, Gunn M, Fang J, Odugbemi T, et al
   Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses : A Retrospective Cohort Study.
   Ann Intern Med. 2025 Apr 22. doi: 10.7326/ANNALS-24-01967.
   PubMed         Abstract available
   
   

   
   Ann Neurol

5. CERFONTAINE MN, Gravesteijn G, Hack RJ, Dijkstra KL, et al
   Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort - Implications for NOTCH3 Variant-Specific Disease Prediction.
   Ann Neurol. 2025 Apr 23. doi: 10.1002/ana.27240.
   PubMed         Abstract available
   
   

   
   BMC Neurol

6. MATERNE M, Lindvall MA, Appelros P, Eriksson O, et al
   Post-stroke fatigue: The role of comorbidities and its impact on quality of life.
   BMC Neurol. 2025;25:177.
   PubMed         Abstract available
   
   

   
   Cerebrovasc Dis

7. MIAO M, Ye C, Wang Z, Long J, et al
   Traditional lipid ratios and carotid atherosclerosis in patients with ischemic stroke.
   Cerebrovasc Dis. 2025 Apr 24:1-21. doi: 10.1159/000545676.
   PubMed         Abstract available
   
   

   
   Circ Cardiovasc Interv

8. KJAERGAARD J, Moller CH, Wiberg S, Mikkelsen AD, et al
   Efficacy of the Glucagon-Like Peptide-1 Agonist Exenatide in Patients Undergoing CABG or Aortic Valve Replacement: A Randomized Double-Blind Clinical Trial.
   Circ Cardiovasc Interv. 2025 Apr 23:e014961.
   PubMed         Abstract available
   
   

   
   Circ Cardiovasc Qual Outcomes

9. THANGARAJ PM, Oikonomou EK, Dhingra LS, Aminorroaya A, et al
   Computational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference.
   Circ Cardiovasc Qual Outcomes. 2025 Apr 22:e011306.
   PubMed         Abstract available
   
   

   
   Circ Heart Fail

10. RATCHFORD SM, Clifton HL, Gifford JR, LaSalle DT, et al
    Impact of Acute Antioxidant and Tetrahydrobiopterin (BH(4)) Administration on Locomotor Muscle Microvascular Function in Patients With Heart Failure.
    Circ Heart Fail. 2025 Apr 24:e012446. doi: 10.1161/CIRCHEARTFAILURE.124.012446.
    PubMed         Abstract available
    
    

    
    Circulation

11. LEE J, Balzraine B, Schweizer A, Kuzmanova V, et al
    Correction to: Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke.
    Circulation. 2025;151:e961.
    PubMed        
    
    
12. ZIMERMAN A, Kunzler ALF, Weber BN, Ran X, et al
    Intensive Lowering of LDL Cholesterol Levels With Evolocumab in Autoimmune or Inflammatory Diseases: An Analysis of the FOURIER Trial.
    Circulation. 2025 Apr 21. doi: 10.1161/CIRCULATIONAHA.124.072756.
    PubMed         Abstract available
    
    

    
    Cochrane Database Syst Rev

13. GOTTLIEB M, Carlson JN, Westrick J, Peksa GD, et al
    Endovascular thrombectomy with versus without intravenous thrombolysis for acute ischaemic stroke.
    Cochrane Database Syst Rev. 2025;4:CD015721.
    PubMed         Abstract available
    
    

    
    Eur Heart J

14. LEAR SA, McKee M, Hystad P, Byron Walker B, et al
    Social factors, health policy, and environment: implications for cardiovascular disease across the globe.
    Eur Heart J. 2025 Apr 22:ehaf212. doi: 10.1093.
    PubMed         Abstract available
    
    

    
    Int J Stroke

15. DEB B, Vasireddi S, Bhatia NK, Rogers AJ, et al
    Non-Cardiac and Cardiac Risk for Ischemic Stroke in Young Adults: The Stanford Y-CORE (Young Cardiovascular Outcomes and Risk Evaluation) Study.
    Int J Stroke. 2025 Apr 19:17474930251338611. doi: 10.1177/17474930251338611.
    PubMed         Abstract available
    
    
16. LYNCH EA, Nesbitt K, Gulyani A, Chan RJ, et al
    Do self-management interventions improve self-efficacy and health-related quality of life after stroke? A systematic review.
    Int J Stroke. 2025 Apr 24:17474930251340286. doi: 10.1177/17474930251340286.
    PubMed         Abstract available
    
    
17. LIU D, Yan H, Gao Y, Chen W, et al
    Effect of history of hypertension on efficacy of clopidogrel-aspirin in ischemic stroke.
    Int J Stroke. 2025 Apr 19:17474930251338618. doi: 10.1177/17474930251338618.
    PubMed         Abstract available
    
    

    
    J Neuroeng Rehabil

18. WANG H, Guo J, Zhang Y, Fu Z, et al
    Closed-loop rehabilitation of upper-limb dyskinesia after stroke: from natural motion to neuronal microfluidics.
    J Neuroeng Rehabil. 2025;22:87.
    PubMed         Abstract available
    
    
19. LEE SH, Kim J, Lee HJ, Kim YH, et al
    A wearable ankle-assisted robot for improving gait function and pattern in stroke patients.
    J Neuroeng Rehabil. 2025;22:89.
    PubMed         Abstract available
    
    
20. GERMANOTTA M, Mauro MC, Falchini F, Scotto Di Luzio F, et al
    A robotic rehabilitation intervention in a home setting during the Covid-19 outbreak: a feasibility pilot study in patients with stroke.
    J Neuroeng Rehabil. 2025;22:93.
    PubMed         Abstract available
    
    
21. MANSOUR S, Giles J, Nair KPS, Marshall R, et al
    A clinical trial evaluating feasibility and acceptability of a brain-computer interface for telerehabilitation in patients with stroke.
    J Neuroeng Rehabil. 2025;22:91.
    PubMed         Abstract available
    
    
22. OLANA DD, Abessa TG, Lamba D, Triccas LT, et al
    Effect of virtual reality-based upper limb training on activity of daily living and quality of life among stroke survivors: a systematic review and meta-analysis.
    J Neuroeng Rehabil. 2025;22:92.
    PubMed         Abstract available
    
    

    
    J Stroke Cerebrovasc Dis

23. FAVILLA CG, Mullen MT, Konecky S, McCardell T, et al
    Pre-hospital LVO Detection: One Size Does Not Fit All.
    J Stroke Cerebrovasc Dis. 2025 Apr 17:108323.
    PubMed         Abstract available
    
    
24. SHANG J, Wu Y, Zhang L, Jiang X, et al
    Joint effect of modifiable risk factors and genetic susceptibility on ischaemic stroke.
    J Stroke Cerebrovasc Dis. 2025;34:108313.
    PubMed         Abstract available
    
    
25. KESTEN J, Mlynash M, Yuen N, Seners P, et al
    Acute ischemic stroke patient factors associated with poor outcomes in patients with favorable collaterals and successful thrombectomy.
    J Stroke Cerebrovasc Dis. 2025;34:108311.
    PubMed         Abstract available
    
    
26. FARMANI V, Kniep H, Maros ME, Lyashevska O, et al
    Estimating Individualized Effectiveness of Receiving Successful Recanalization for Ischemic Stroke Cases Using Machine Learning Techniques.
    J Stroke Cerebrovasc Dis. 2025 Apr 18:108324.
    PubMed         Abstract available
    
    

    
    JAMA Neurol

27. BUTCHER KS, Buck B, Dowlatshahi D, Gioia LC, et al
    Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage.
    JAMA Neurol. 2025 Apr 21:e250586. doi: 10.1001/jamaneurol.2025.0586.
    PubMed         Abstract available
    
    

    
    Lancet Neurol

28. DONNERS SJA, van Velzen TJ, Cheng SF, Gregson J, et al
    Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial.
    Lancet Neurol. 2025;24:389-399.
    PubMed         Abstract available
    
    
29. HO JK, Hankey GJ
    Carotid revascularisation for carotid stenosis.
    Lancet Neurol. 2025;24:372-373.
    PubMed        
    
    

    
    Neurology

30. VAN AMERONGEN S, Peskind ER, Tripodis Y, Adler CH, et al
    Catecholamine Dysregulation in Former American Football Players: Findings From the DIAGNOSE CTE Research Project.
    Neurology. 2025;104:e213584.
    PubMed         Abstract available
    
    
31. ZHANG Y, Yang S, Wang S, Zou X, et al
    Prevalence and 10-Year Risk of Intracerebral Hemorrhage in Central China Using Estimates From the 1 Million Cross-Sectional Study.
    Neurology. 2025;104:e213545.
    PubMed         Abstract available
    
    

    
    PLoS One

32. LIU J, Jiang S, Cui X, Bai X, et al
    Relationship between cardio-ankle vascular index value and stroke in hypertension patients cardio-ankle vascular index >==9.
    PLoS One. 2025;20:e0321298.
    PubMed         Abstract available
    
    
33. YANG J, Ma YM, Yang L, Li P, et al
    Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1.
    PLoS One. 2025;20:e0321006.
    PubMed         Abstract available
    
    
34. OSKARSSON V, Salomaa V, Jousilahti P, Palmieri L, et al
    Cardiovascular disease outcomes in relation to 25-hydroxyvitamin D and its seasonal variation: Results from the BiomarCaRE consortium.
    PLoS One. 2025;20:e0319607.
    PubMed         Abstract available
    
    
35. BEAUREGARD LH, Bazarian JJ, Johnson BD, Cheng H, et al
    Investigating omega-3 fatty acids' neuroprotective effects in repetitive subconcussive neural injury: Study protocol for a randomized placebo-controlled trial.
    PLoS One. 2025;20:e0321808.
    PubMed         Abstract available
    
    
36. HELANDER M, Iirola T, Ylikotila P, Nordquist H, et al
    Evaluation of pre- and in-hospital workflows and time intervals with acute ischemic stroke patients.
    PLoS One. 2025;20:e0319783.
    PubMed         Abstract available
    
    
37. HE W, Shi J, Qian Y, Fan T, et al
    Evidence to shared genetic correlation of ischemic stroke and intracerebral hemorrhage and cardiovascular related traits.
    PLoS One. 2025;20:e0320479.
    PubMed         Abstract available
    
    

    
    Stroke

38. KHAN F, Yogendrakumar V, Menon BK
    Endovascular Thrombectomy for Ischemic Stroke With Large Infarct.
    Stroke. 2025 Apr 25. doi: 10.1161/STROKEAHA.125.050897.
    PubMed         Abstract available
    
    
39. XU Y, Xiao L, Zhang P, Shi W, et al
    One-Year Outcome After Endovascular Thrombectomy for Basilar Artery Occlusion With Mild Deficits.
    Stroke. 2025 Apr 25. doi: 10.1161/STROKEAHA.124.050389.
    PubMed         Abstract available
    
    
40. VOS EM, Peeters-Scholte CMPCD, Boiten J, Hund HM, et al
    Safety, Tolerability, and Pharmacokinetics of the Neuroprotectant 2-Iminobiotin in Patients With Large-Vessel Occlusion Ischemic Stroke Treated With Endovascular Thrombectomy.
    Stroke. 2025 Apr 24. doi: 10.1161/STROKEAHA.125.050560.
    PubMed         Abstract available
    
    
41. DALLI LL, Andrew NE, Olaiya MT, Cadilhac DA, et al
    Sex Differences in Prescription, Initiation, and Discontinuation of Secondary Prevention Medications After Stroke.
    Stroke. 2025 Apr 24. doi: 10.1161/STROKEAHA.124.050207.
    PubMed         Abstract available
    
    
42. SCHUBERT KM, Zieglgansberger D, Bicciato G, Abraira L, et al
    Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality.
    Stroke. 2025 Apr 24. doi: 10.1161/STROKEAHA.124.050045.
    PubMed         Abstract available
    
    
43. MAURY A, Benzakoun J, Bani-Sadr A, Ter Schiphorst A, et al
    Diagnostic Accuracy of Finger-Like Projections and Subarachnoid Hemorrhage for Cerebral Amyloid Angiopathy: Pathological Validation From Lobar Hematoma Evacuation or Brain Biopsy.
    Stroke. 2025 Apr 24. doi: 10.1161/STROKEAHA.124.050159.
    PubMed         Abstract available
    
    
44. YU JB, Hong C, Ren XW, Guo W, et al
    FTY720 Modulating Microglia-Mediated Cholesterol Recycling via TREM2 Promotes Remyelination Following Ischemic Damage.
    Stroke. 2025 Apr 22. doi: 10.1161/STROKEAHA.124.049745.
    PubMed         Abstract available
    
    
45. HATAB I, Kneihsl M, Arnold M, Pokorny T, et al
    Role of NT-proBNP for Atrial Fibrillation Detection After Ischemic Stroke: A Time-Dependent Relationship.
    Stroke. 2025 Apr 21. doi: 10.1161/STROKEAHA.124.049249.
    PubMed         Abstract available
    
    
46. VU S, Mahmoud N, Sivakumar S, Yazdanian F, et al
    Dilemmas in Secondary Stroke Prevention.
    Stroke. 2025 Apr 21. doi: 10.1161/STROKEAHA.124.050403.
    PubMed         Abstract available
    
    
47. HANMER J, Arnold J, Hall A, Ratcliff JJ, et al
    Cost-Effectiveness Analysis of Early Minimally Invasive Removal of Intracerebral Hemorrhage.
    Stroke. 2025 Apr 25. doi: 10.1161/STROKEAHA.124.048493.
    PubMed         Abstract available
    
    
48. YUAN L, Wang Y, Hu X, Zuo Y, et al
    Time-of-Day-Dependent Effects of Rehabilitation on Motor Recovery After Experimental Focal Cerebral Ischemia.
    Stroke. 2025 Apr 25. doi: 10.1161/STROKEAHA.125.050084.
    PubMed         Abstract available
    
    

    
    World Neurosurg

49. LUO R, Liu T, Li W, Zhu C, et al
    Age-Dependent Risk Factors for Hemorrhagic Events in Moyamoya Disease: The Role of Collateral Vessels.
    World Neurosurg. 2025 Apr 21:124000. doi: 10.1016/j.wneu.2025.124000.
    PubMed         Abstract available
    
    

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