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  Venous Thrombosis

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Articles published in Thromb Haemost

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Single Articles


    June 2025
  1. PITITTO GN, Maraziti G, Squizzato A, Becattini C, et al
    Direct oral anticoagulants for prevention of venous thromboembolism after cancer-related surgery: systematic review and network meta-analysis.
    Thromb Haemost. 2025 Jun 5. doi: 10.1055/a-2628-3967.
    PubMed     Abstract available


  2. VEDOVATI MC, Talerico R, Sacco C, Mazzetti M, et al
    Major Bleeding Risk Assessment in Patients with Cancer-Associated Venous Thromboembolism Treated with DOACs: Data from a Multicenter Cohort.
    Thromb Haemost. 2025 Jun 3. doi: 10.1055/a-2605-9015.
    PubMed     Abstract available


    May 2025
  3. TAFUR A, Brenner B, Demelo-Rodriguez P, Guirado Torrecillas L, et al
    Geographic and Racial Variation in Outcomes of Acute Venous Thromboembolism: Insights from the RIETE Registry.
    Thromb Haemost. 2025 May 19. doi: 10.1055/a-2615-4591.
    PubMed     Abstract available


  4. GMEINER J, Kaiser R, Fischer J, Kraechan A, et al
    Thromboembolic risk among patients on dual antiplatelet therapy with or without heparin thromboprophylaxis.
    Thromb Haemost. 2025 May 19. doi: 10.1055/a-2615-4785.
    PubMed     Abstract available


  5. MARZO C, Solanich T, Tassies D, Pina E, et al
    Consensus on the Management of the Clinical Challenges of Venous Thromboembolism in Special Situations.
    Thromb Haemost. 2025 May 13. doi: 10.1055/a-2595-1811.
    PubMed     Abstract available


  6. LUNDBECH M, Krag AE, Iversen LH, Brandsborg B, et al
    Elevated Thrombin Generation and Venous Thromboembolism Incidence in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Compared with Minimally Invasive Rectal Surgery.
    Thromb Haemost. 2025;125:460-469.
    PubMed     Abstract available


    April 2025
  7. YAN X, Huang W, Chen Y
    Serum MPO-DNA for Predicting the Risk of Venous Thromboembolism and the Effect of Statins in Patients with Spontaneous Intracerebral Hemorrhage.
    Thromb Haemost. 2025 Apr 28. doi: 10.1055/a-2595-1927.
    PubMed     Abstract available


  8. BIRRENKOTT DA, Kabrhel C
    The Plasma Proteome and Risk of Future Venous Thromboembolism-Results from the HUNT Study in Thrombosis and Haemostasis.
    Thromb Haemost. 2025 Apr 25. doi: 10.1055/a-2575-3388.
    PubMed    


  9. LEKNESSUND OGR, Hansen JB, Braekkan SK
    Resting heart rate and risk of incident venous thromboembolism - the Tromso study.
    Thromb Haemost. 2025 Apr 24. doi: 10.1055/a-2593-1679.
    PubMed     Abstract available


    March 2025
  10. LAROUCHE A, Dollo V, Mercier G, Singbo N, et al
    Impact of Obesity and Overweight on Heparin Dosing and Clinical Outcomes in Pediatric Patients with Venous Thromboembolism.
    Thromb Haemost. 2025 Mar 24. doi: 10.1055/a-2544-6183.
    PubMed     Abstract available


    February 2025
  11. JANATA K, Lipa AJ, Merrelaar A, Merrelaar M, et al
    Enhancing Pulmonary Embolism Risk Stratification: The National Early Warning Score and Its Integration into the ESC Classification.
    Thromb Haemost. 2025 Feb 24. doi: 10.1055/a-2544-3626.
    PubMed     Abstract available


    January 2025
  12. SOLER E, Roldan V, Marin F
    Stress, Partner Violence, and Coagulopathy: Unmasking New Triggers for Venous Thromboembolism.
    Thromb Haemost. 2025 Jan 27. doi: 10.1055/a-2520-8725.
    PubMed     Abstract available


  13. HOFMANN E, Stalder O, Mean M, Rodondi N, et al
    Anemia and Prognosis in Patients with Acute Venous Thromboembolism.
    Thromb Haemost. 2025 Jan 27. doi: 10.1055/a-2510-6301.
    PubMed     Abstract available


  14. KEMPERS E, Visser C, Geijteman E, Goedegebuur J, et al
    Discontinuation of anticoagulants and occurrence of bleeding and thromboembolic events in vitamin K antagonist users with a life-limiting disease.
    Thromb Haemost. 2025 Jan 24. doi: 10.1055/a-2524-5334.
    PubMed     Abstract available


  15. AGNELLI G, Hoffmann U, Hainaut P, Gaine S, et al
    Treatment of Venous Thromboembolism with Edoxaban over 18 Months: Results from ETNA-VTE Europe.
    Thromb Haemost. 2025 Jan 16. doi: 10.1055/a-2497-4089.
    PubMed     Abstract available


  16. KONSTANTINIDES S, Christodoulou K, Mohr K, Uphaus T, et al
    Hospital Costs of Intracranial Haemorrhage in Patients with Acute Pulmonary Embolism: Possible Implications for Emerging Therapies.
    Thromb Haemost. 2025 Jan 8. doi: 10.1055/a-2511-4599.
    PubMed     Abstract available


    December 2024
  17. MOHR K, Neusius T, Barco S, Konstantinides S, et al
    Socio-Economic Burden of Pulmonary Embolism in Europe: Shifting Priorities and Challenges for Novel Reperfusion Strategies.
    Thromb Haemost. 2024 Dec 19. doi: 10.1055/a-2505-8711.
    PubMed     Abstract available


  18. BITSADZE V, Nikolaeva MG, Mousty E, Khizroeva J, et al
    Venous Thromboembolism at Low Risk of Recurrence in Young Women: Stress and Violence Associated with Recurrence. An International Case-Control Study.
    Thromb Haemost. 2024 Dec 18. doi: 10.1055/a-2484-0923.
    PubMed     Abstract available


  19. GUAN Y, Gan Z, Li S, Cao X, et al
    C-reactive protein, genetic susceptibility, and the long-term risk of venous thromboembolism in patients with past cancer.
    Thromb Haemost. 2024 Dec 3. doi: 10.1055/a-2495-1350.
    PubMed     Abstract available


    November 2024
  20. BRAEKKAN SK, Onsaker AL, Nost TH, Tang W, et al
    The plasma proteome and risk of future venous thromboembolism - results from the HUNT study.
    Thromb Haemost. 2024 Nov 25. doi: 10.1055/a-2484-0836.
    PubMed     Abstract available


  21. BARBA R
    Are More Patients with Thromboembolic Disease Dying Now Than Before?
    Thromb Haemost. 2024 Nov 11. doi: 10.1055/a-2436-4669.
    PubMed    


  22. GRANDONE E, Mastroianno M, Pacilli G, Colaizzo D, et al
    Blood Loss in Women of Childbearing Potential Taking Oral Anticoagulants for Venous Thromboembolism (The BLEED Study).
    Thromb Haemost. 2024 Nov 6. doi: 10.1055/a-2461-6822.
    PubMed     Abstract available


  23. XIAN W, Tao Y, You C, Sun R, et al
    Brisk walking pace offsets venous thromboembolism risk equivalent to established monogenic mutations.
    Thromb Haemost. 2024 Nov 5. doi: 10.1055/a-2461-3349.
    PubMed     Abstract available


    October 2024
  24. LYU Y, Li H, Liu X, Zhang X, et al
    Estimated GFR Decline is Causally Associated with Acute Pulmonary Embolism: A Nested Case-Control and Mendelian Randomization Study.
    Thromb Haemost. 2024 Oct 14. doi: 10.1055/a-2439-5200.
    PubMed     Abstract available


  25. RANALLI P, Ten Cate H
    Venous Thromboembolism Prophylaxis after hematopoietic cell transplantation: still a challenge for haematologists and haemostasiologists.
    Thromb Haemost. 2024 Oct 4. doi: 10.1055/a-2434-5010.
    PubMed     Abstract available


  26. DU HC, Zheng YF, Shen MQ, Deng BY, et al
    Reply to "Commentary: 'No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study' ".
    Thromb Haemost. 2024 Oct 3. doi: 10.1055/s-0044-1791679.
    PubMed    


    September 2024
  27. BIONDI F, Alberti M, Montemaggi E, D'Alleva A, et al
    Not just CTEPH: a narrative review on the spectrum approach to post pulmonary embolism conditions.
    Thromb Haemost. 2024 Sep 19. doi: 10.1055/a-2418-7895.
    PubMed     Abstract available


  28. LANTING V, Takada T, Bosch F, Marshall A, et al
    Risk of recurrent venous thromboembolism in patients with cancer: an individual patient data meta-analysis and development of a prediction model.
    Thromb Haemost. 2024 Sep 19. doi: 10.1055/a-2418-3960.
    PubMed     Abstract available


  29. DE CORTE P, Milhoranca I, Mechsner S, Oberg SA, et al
    Unravelling the causal relationship between endometriosis and the risk for developing venous thromboembolism: a pooled analysis.
    Thromb Haemost. 2024 Sep 2. doi: 10.1055/a-2407-9498.
    PubMed     Abstract available


  30. DOLDI F, Gessler N, Anwar O, Kahle AK, et al
    In-Hospital Pulmonary Arterial Embolism after Catheter Ablation of Over 45,000 Cardiac Arrhythmias: Individualized Case Analysis of Multicentric Data.
    Thromb Haemost. 2024;124:861-869.
    PubMed     Abstract available


    August 2024
  31. GLISE SANDBLAD K, Svensson CJ, Svennerholm K, Philipson J, et al
    Time trends and excess mortality compared to population controls after a first-time pulmonary embolism or deep vein thrombosis.
    Thromb Haemost. 2024 Aug 23. doi: 10.1055/a-2402-6192.
    PubMed     Abstract available


  32. KAPTEIJN MY, Bakker N, Koekkoek JAF, Versteeg HH, et al
    Venous Thromboembolism in Patients with Glioblastoma: Molecular Mechanisms and Clinical Implications.
    Thromb Haemost. 2024 Aug 21. doi: 10.1055/s-0044-1789592.
    PubMed     Abstract available


  33. KONSTANTINIDES SV
    Shifting Priorities in the Prevention of Venous Thromboembolism: Time to Focus on Overall Cardiovascular Health.
    Thromb Haemost. 2024 Aug 12. doi: 10.1055/s-0044-1788926.
    PubMed    


  34. PASTORI D, Palareti G
    Open Issues in the Choice and Management of Direct Oral Anticoagulants in Patients with Cancer-Related Venous Thromboembolism.
    Thromb Haemost. 2024 Aug 6. doi: 10.1055/s-0044-1788997.
    PubMed    


  35. PASTORI D, Sciacqua A
    Educational Attainment, Obesity, and Venous Thromboembolism. Is Only Matter of Weight?
    Thromb Haemost. 2024 Aug 1. doi: 10.1055/s-0044-1788904.
    PubMed    


    July 2024
  36. MUJOVIC N, Potpara TS
    Pulmonary Thromboembolism After Catheter Ablation of Cardiac Arrhythmias.
    Thromb Haemost. 2024 Jul 16. doi: 10.1055/a-2366-7245.
    PubMed     Abstract available


  37. GRANAT LM, Li H, Ondeck M, Osantowski B, et al
    Venous Thromboembolism Post-Allogeneic Hematopoietic Cell Transplant: Risk Factors, Incidence and Outcomes.
    Thromb Haemost. 2024 Jul 15. doi: 10.1055/a-2365-8883.
    PubMed     Abstract available


    June 2024
  38. LIU J, Zhang Y, Zeng B
    Commentary: "No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study".
    Thromb Haemost. 2024 Jun 6. doi: 10.1055/s-0044-1787653.
    PubMed    


    May 2024
  39. GORAYA SR, O'Hare C, Grace KA, Schaeffer WJ, et al
    Optimizing Use of High-Sensitivity Troponin for Risk-Stratification of Acute Pulmonary Embolism.
    Thromb Haemost. 2024 May 24. doi: 10.1055/s-0044-1786820.
    PubMed     Abstract available


  40. ROY DC, Wang TF, Lun R, Zahrai A, et al
    Circulating Blood Biomarkers and Risk of Venous Thromboembolism in Cancer Patients: A Systematic Review and Meta-Analysis.
    Thromb Haemost. 2024 May 20. doi: 10.1055/a-2330-1371.
    PubMed     Abstract available


  41. XIANG H, Liu M, Zhou C, Huang Y, et al
    Tea Consumption, Milk or Sweeteners Addition, Genetic Variation in Caffeine Metabolism, and Incident Venous Thromboembolism.
    Thromb Haemost. 2024 May 10. doi: 10.1055/s-0044-1786819.
    PubMed     Abstract available


  42. DU HC, Deng BY
    Obesity-Related Traits Mediate the Effects of Educational Attainment on the Risk of Varicose Veins, Venous Thromboembolism, and Phlebitis.
    Thromb Haemost. 2024 May 10. doi: 10.1055/s-0044-1786970.
    PubMed     Abstract available


  43. NYGREN D, Torisson G, Happonen L, Mellhammar L, et al
    Proteomic Characterization of Plasma in Lemierre's Syndrome.
    Thromb Haemost. 2024;124:432-440.
    PubMed     Abstract available


    April 2024
  44. SUETA D, Yamashita Y, Morimoto T, Chatani R, et al
    Edoxaban, Rivaroxaban or Apixaban for Cancer-Associated Venous Thromboembolism in the Real World: Insights from the COMMAND VTE Registry-2.
    Thromb Haemost. 2024 Apr 29. doi: 10.1055/a-2316-5269.
    PubMed     Abstract available


  45. WANG Y, Hu X, Wang X, Li L, et al
    Exploring the Two-Way Link Between Migraines and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.
    Thromb Haemost. 2024 Apr 24. doi: 10.1055/a-2313-0311.
    PubMed     Abstract available


  46. HUANG Z, Zheng Z, Pang L, Fu K, et al
    The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.
    Thromb Haemost. 2024 Apr 17. doi: 10.1055/a-2308-2290.
    PubMed     Abstract available


  47. CHOI D, Froess JD, Lawler PR, Neal MD, et al
    Whole Blood Viscosity and Thromboembolic Events in Hospitalized Patients with COVID-19: Post hoc Analysis of the ATTACC/ACTIV-4a Trial.
    Thromb Haemost. 2024 Apr 16. doi: 10.1055/s-0044-1786030.
    PubMed    


  48. LIANG B, Zha L, Peng B, Chen Q, et al
    Association of Cardiovascular Health with the Incidence of Venous Thromboembolism: A Prospective Study of 275,149 Participants from the UK Biobank.
    Thromb Haemost. 2024 Apr 12. doi: 10.1055/a-2305-6631.
    PubMed     Abstract available


  49. DANILATOU V, Dimopoulos D, Kostoulas T, Douketis J, et al
    Machine learning-based predictive models for patients with venous thromboembolism: A Systematic Review.
    Thromb Haemost. 2024 Apr 4. doi: 10.1055/a-2299-4758.
    PubMed     Abstract available


    February 2024
  50. DU HC, Zheng YF, Shen MQ, Deng BY, et al
    No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study.
    Thromb Haemost. 2024 Feb 22. doi: 10.1055/s-0044-1781425.
    PubMed     Abstract available


  51. YU J, Wang T, Zhang X, Chen Q, et al
    Anti-thrombotic Effects Mediated by a Novel Dual-Target Peptide Inhibiting Both Platelet Aggregation and Thrombin Activity without Causing Bleeding.
    Thromb Haemost. 2024;124:108-121.
    PubMed     Abstract available


    January 2024
  52. COHEN AT, Creeper KJ, Alikhan R, Er C, et al
    Early Time Courses of Recurrent Venous Thromboembolism and Bleeding during Apixaban or Dalteparin Therapy for Patients with Cancer.
    Thromb Haemost. 2024 Jan 9. doi: 10.1055/s-0043-1778642.
    PubMed     Abstract available


    December 2023
  53. HU T, Su P, Yang F, Ying J, et al
    Circulating Cytokines and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.
    Thromb Haemost. 2023 Dec 18. doi: 10.1055/s-0043-1777351.
    PubMed     Abstract available


  54. STEINER D, Horvath-Puho E, Jorgensen H, Laugesen K, et al
    Risk of depression after venous thromboembolism in patients with hematological cancer: A population-based cohort study.
    Thromb Haemost. 2023 Dec 11. doi: 10.1055/a-2225-5428.
    PubMed     Abstract available


  55. UJUETA F
    Dietary manganese and the incidence of venous thromboembolism: Evidence for minerals and vitamins and comorbidities linked to venous thromboembolism.
    Thromb Haemost. 2023 Dec 11. doi: 10.1055/a-2225-5513.
    PubMed     Abstract available


    November 2023
  56. HUANG Y, Zhang Y, Yang S, Xiang H, et al
    Association and pathways between dietary manganese intake and incident venous thromboembolism.
    Thromb Haemost. 2023 Nov 20. doi: 10.1055/a-2213-8939.
    PubMed     Abstract available


    October 2023
  57. SIGUENZA P, Lopez Nunez JJ, Falga Tirado C, Gomez-Cuervo C, et al
    Enoxaparin for the long-term therapy of venous thromboembolism in patients with cancer and renal insufficiency.
    Thromb Haemost. 2023 Oct 13. doi: 10.1055/a-2191-7510.
    PubMed     Abstract available


  58. DIX C, Moloney M, Tran H, McFayden J, et al
    Venous thromboembolism and estrogen-containing gender-affirming hormone therapy.
    Thromb Haemost. 2023 Oct 10. doi: 10.1055/a-2188-8898.
    PubMed     Abstract available


  59. HUSSAINI P, Larsen TL, Ghanima W, Dahm AEA, et al
    Risk factors for bleeding in cancer patients treated with conventional dose followed by low dose apixaban for venous thromboembolism.
    Thromb Haemost. 2023 Oct 10. doi: 10.1055/a-2188-8773.
    PubMed     Abstract available


  60. MARTIN KA, Zakai NA
    Venous Thromboembolism and Obesity: Moving Toward a Better Understanding of the Population-Attributable Risk.
    Thromb Haemost. 2023 Oct 9. doi: 10.1055/s-0043-1776010.
    PubMed    


  61. GOLDHABER SZ
    Obesity and Pulmonary Embolism: Can we Dismantle the "Obesity Paradox".
    Thromb Haemost. 2023 Oct 6. doi: 10.1055/a-2187-0966.
    PubMed     Abstract available


    September 2023
  62. ROLDAN V, Soler-Espejo E, Marin F
    Predicting Bleeding in Cancer-Associated Venous Thromboembolism: Another Milestone Achieved.
    Thromb Haemost. 2023 Sep 11. doi: 10.1055/s-0043-1775582.
    PubMed    


    August 2023
  63. KONSTANTINIDES S
    Kidney Disease and Cancer Risk in Patients with Venous Thromboembolism: What Does it Mean for Clinical Practice?
    Thromb Haemost. 2023 Aug 11. doi: 10.1055/a-2152-4762.
    PubMed     Abstract available


  64. FRISCHMUTH T, Tondel BG, Braekkan SK, Hansen JB, et al
    The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study.
    Thromb Haemost. 2023 Aug 7. doi: 10.1055/s-0043-1772212.
    PubMed     Abstract available


  65. COHEN AT, Wallenhorst C, Choudhuri S, Nassar A, et al
    A novel risk prediction score for clinically significant bleeding in patients anticoagulated for venous thromboembolism with active cancer.
    Thromb Haemost. 2023 Aug 1. doi: 10.1055/a-2145-7238.
    PubMed     Abstract available


    July 2023
  66. CHAN N, Germini F
    Patterns and persistence of anticoagulant use in the treatment of venous thromboembolism: insights from South Korea.
    Thromb Haemost. 2023 Jul 18. doi: 10.1055/a-2131-7066.
    PubMed     Abstract available


  67. CHAN N, Xu K
    Risk factors for venous thromboembolism in women of childbearing age.
    Thromb Haemost. 2023 Jul 7. doi: 10.1055/a-2125-3290.
    PubMed     Abstract available


  68. QIAO L, Yao Y, Wu D, Xu R, et al
    The validation and modification of the Caprini risk assessment model (RAM) for evaluating venous thromboembolism (VTE) after joint arthroplasty.
    Thromb Haemost. 2023 Jul 4. doi: 10.1055/a-2122-7780.
    PubMed     Abstract available


  69. KHORANA AA
    Immune Checkpoint Inhibitors And Venous Thromboembolism: The More Things Change....
    Thromb Haemost. 2023 Jul 3. doi: 10.1055/a-2121-9679.
    PubMed     Abstract available


    June 2023
  70. GAUGLER JO, Righini M, Robert-Ebadi H, Sanchez O, et al
    Obesity as a Predictor for Pulmonary Embolism and Performance of the Age-Adjusted D-Dimer Strategy in Obese Patients with Suspected Pulmonary Embolism.
    Thromb Haemost. 2023 Jun 12. doi: 10.1055/s-0043-57018.
    PubMed     Abstract available


  71. YOON D, Jeong HE, Choi S, Shin JY, et al
    Dynamic Patterns and Persistence of Anticoagulation Therapy in Patients with Venous Thromboembolism in South Korea: A Nationwide Cohort Study.
    Thromb Haemost. 2023 Jun 7. doi: 10.1055/a-2107-0815.
    PubMed     Abstract available


  72. TSAI CT, Chao TF
    Incidence and Risk Factors for Pregnancy-Associated Venous Thromboembolism: Are There Differences between East and West?
    Thromb Haemost. 2023 Jun 5. doi: 10.1055/s-0043-1769736.
    PubMed    


  73. GRANDONE E, Antonucci E, Colaizzo D, De Laurenzo A, et al
    Venous thromboembolism in women of childbearing age: insights from the START registry.
    Thromb Haemost. 2023 Jun 1. doi: 10.1055/s-0043-1769592.
    PubMed     Abstract available


    May 2023
  74. LE SEVE JD, Guedon AF, Bordenave S, Agard C, et al
    Risk Factors of Venous Thromboembolic Disease in Cancer Patients Treated with Immune Checkpoint Inhibitor.
    Thromb Haemost. 2023 May 31. doi: 10.1055/s-0043-1769609.
    PubMed     Abstract available


  75. MILLING TJ
    The Hard Bargain of Anticoagulation after Intracranial Haemorrhage, in the setting of Venous Thromboembolism: Between a rock and a hard place.
    Thromb Haemost. 2023 May 22. doi: 10.1055/a-2097-0775.
    PubMed     Abstract available


  76. GIANNIS D, Goldin M, Rahman H, Sison CP, et al
    Risk factors for post-discharge major thromboembolism and mortality in hospitalized patients with COVID-19 with cardiovascular comorbidities.
    Thromb Haemost. 2023 May 5. doi: 10.1055/a-2087-3003.
    PubMed     Abstract available


  77. XU K, Chan NC
    Recurrent Thrombosis and Bleeding in Patients with Cancer-Associated Venous Thromboembolism Receiving Anticoagulation: Are These Modifiable Risk Factors for Mortality?
    Thromb Haemost. 2023;123:487-489.
    PubMed    


    April 2023
  78. JOHNSEN SP, Jensen M, Munster AB, Frost L, et al
    Small-area analysis of treatment and clinical outcomes in patients with venous thromboembolism in Denmark: a nationwide cohort study.
    Thromb Haemost. 2023 Apr 13. doi: 10.1055/a-2073-4336.
    PubMed     Abstract available


  79. GORMAN J, Candeloro M, Schulman S
    Anticoagulant management and outcomes in non-traumatic intracranial hemorrhage complicated by venous thromboembolism: a retrospective chart review.
    Thromb Haemost. 2023 Apr 4. doi: 10.1055/a-2068-6464.
    PubMed     Abstract available


    March 2023
  80. KONSTANTINIDES S
    Modern lung scintigraphy techniques for optimising the diagnosis of pulmonary embolism: Great expectations, still waiting to be met.
    Thromb Haemost. 2023 Mar 19. doi: 10.1055/a-2057-8672.
    PubMed     Abstract available


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