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  Alzheimer's Disease

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Articles published in J Neurochem

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    December 2017
  1. BRACZYNSKI AK, Schulz JB, Bach JP
    Vaccination strategies in tauopathies and synucleinopathies.
    J Neurochem. 2017;143:467-488.
    PubMed     Text format     Abstract available


    November 2017
  2. MOLNAR E
    New tool to tackle Alzheimer's disease: amyloid-beta protofibril-selective antibody AbSL: An Editorial Highlight for 'The conformational epitope for a new Abeta42 protofibril-selective antibody partially overlaps with the peptide N-terminal region' on
    J Neurochem. 2017 Nov 23. doi: 10.1111/jnc.14240.
    PubMed     Text format     Abstract available


  3. KUSAKARI S, Nawa M, Sudo K, Matsuoka M, et al
    Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease.
    J Neurochem. 2017 Nov 21. doi: 10.1111/jnc.14258.
    PubMed     Text format     Abstract available


  4. NDAY CM, Eleftheriadou D, Jackson G
    Shared Pathological Pathways of Alzheimer's disease with Specific Comorbidities: Current Perspectives and Interventions.
    J Neurochem. 2017 Nov 21. doi: 10.1111/jnc.14256.
    PubMed     Text format     Abstract available


  5. CHANEY A, Bauer M, Bochicchio D, Smigova A, et al
    Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe xPS1Deltae9 transgenic mouse model of Alzheimer's disease.
    J Neurochem. 2017 Nov 10. doi: 10.1111/jnc.14251.
    PubMed     Text format     Abstract available


    October 2017
  6. BEHL C, Ziegler C
    Beyond Amyloid - Widening the View on Alzheimer's Disease.
    J Neurochem. 2017 Oct 20. doi: 10.1111/jnc.14137.
    PubMed     Text format     Abstract available


  7. WILLIAM REBECK G, Pak DTS
    A mobile APP for sharing contacts on your cell: An Editorial Highlight for 'The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system' on page 11.
    J Neurochem. 2017;143:9-10.
    PubMed     Text format     Abstract available


  8. SOSA LJ, Caceres A, Dupraz S, Oksdath M, et al
    The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system.
    J Neurochem. 2017;143:11-29.
    PubMed     Text format     Abstract available


    August 2017
  9. ROUBROEKS JAY, Smith RG, van den Hove DLA, Lunnon K, et al
    Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases.
    J Neurochem. 2017 Aug 14. doi: 10.1111/jnc.14148.
    PubMed     Text format     Abstract available


    July 2017
  10. LAI AY, McLaurin J
    Rho-associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease.
    J Neurochem. 2017 Jul 19. doi: 10.1111/jnc.14130.
    PubMed     Text format     Abstract available


  11. CHENG S, Wani WY, Hottman DA, Jeong A, et al
    Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.
    J Neurochem. 2017;142:297-304.
    PubMed     Text format     Abstract available


  12. NIGAM SM, Xu S, Kritikou JS, Marosi K, et al
    Exercise and BDNF reduce Abeta production by enhancing alpha-secretase processing of APP.
    J Neurochem. 2017;142:286-296.
    PubMed     Text format     Abstract available


    May 2017
  13. TSE KH, Herrup K
    Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.
    J Neurochem. 2017 May 26. doi: 10.1111/jnc.14079.
    PubMed     Text format     Abstract available


  14. COULSON EJ, Bartlett PF
    An exercise path to preventing Alzheimer's disease: An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing alpha-secretase processing of APP'.
    J Neurochem. 2017 May 18. doi: 10.1111/jnc.14038.
    PubMed     Text format     Abstract available


  15. SILMAN I, Sussman JL
    Recent developments in structural studies on acetylcholinesterase.
    J Neurochem. 2017 May 15. doi: 10.1111/jnc.13992.
    PubMed     Text format     Abstract available


  16. RODRIGUEZ L, Mohamed NV, Desjardins A, Lippe R, et al
    Rab7A regulates tau secretion.
    J Neurochem. 2017;141:592-605.
    PubMed     Text format     Abstract available


    April 2017
  17. ARENDT T, Stieler J, Ueberham U
    Is sporadic Alzheimer's disease a developmental disorder?
    J Neurochem. 2017 Apr 11. doi: 10.1111/jnc.14036.
    PubMed     Text format     Abstract available


    March 2017
  18. PUCHOWICZ MA, Seyfried TN
    Novel ketone body therapy for managing Alzheimer's disease: An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's diseas
    J Neurochem. 2017 Mar 15. doi: 10.1111/jnc.13979.
    PubMed     Text format     Abstract available


  19. BRANDT R, Bakota L
    Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection.
    J Neurochem. 2017 Mar 7. doi: 10.1111/jnc.14011.
    PubMed     Text format     Abstract available


    February 2017
  20. GRALLE M
    The neuronal insulin receptor in its environment.
    J Neurochem. 2017;140:359-367.
    PubMed     Text format     Abstract available


    January 2017
  21. PAWLOSKY RJ, Kemper MF, Kashiwaya Y, King MT, et al
    Effects of a dietary ketone ester on hippocampal glycolytic and TCA cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease.
    J Neurochem. 2017 Jan 18. doi: 10.1111/jnc.13958.
    PubMed     Text format     Abstract available


  22. YAMIN G, Teplow DB
    Pittsburgh Compound-B (PiB) binds amyloid beta-protein protofibrils.
    J Neurochem. 2017;140:210-215.
    PubMed     Text format     Abstract available


    December 2016
  23. WHYTE LS, Lau AA, Hemsley KM, Hopwood JJ, et al
    Endo-lysosomal and autophagic dysfunction: A driving factor in Alzheimer's disease?
    J Neurochem. 2016 Dec 27. doi: 10.1111/jnc.13935.
    PubMed     Text format     Abstract available


  24. SALMINEN A, Kauppinen A, Kaarniranta K
    Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease.
    J Neurochem. 2016 Dec 17. doi: 10.1111/jnc.13932.
    PubMed     Text format     Abstract available


  25. YI B, Sahn JJ, Ardestani PM, Evans AK, et al
    Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuro-inflammation in experimental models of Alzheimer's disease.
    J Neurochem. 2016 Dec 7. doi: 10.1111/jnc.13917.
    PubMed     Text format     Abstract available


    November 2016
  26. ELLISON EM, Abner EL, Lovell MA
    Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease.
    J Neurochem. 2016 Nov 27. doi: 10.1111/jnc.13912.
    PubMed     Text format     Abstract available


    September 2016
  27. IMAMURA O, Arai M, Dateki M, Takishima K, et al
    Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis.
    J Neurochem. 2016 Sep 24. doi: 10.1111/jnc.13856.
    PubMed     Text format     Abstract available


  28. MURAMATSU I, Yoshiki H, Uwada J, Masuoka T, et al
    Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions.
    J Neurochem. 2016 Sep 14. doi: 10.1111/jnc.13843.
    PubMed     Text format     Abstract available


    June 2016
  29. URIBE-ARIAS A, Posada-Duque RA, Gonzalez-Billault C, Villegas A, et al
    p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease.
    J Neurochem. 2016 Jun 8. doi: 10.1111/jnc.13697.
    PubMed     Text format     Abstract available


  30. HENDERSON BW, Gentry EG, Rush T, Troncoso JC, et al
    Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-beta levels in brain.
    J Neurochem. 2016 Jun 1. doi: 10.1111/jnc.13688.
    PubMed     Text format     Abstract available


    May 2016
  31. GOLDE TE
    Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies.
    J Neurochem. 2016 May 4. doi: 10.1111/jnc.13583.
    PubMed     Text format     Abstract available


  32. KIM J, Yoon H, Chung DE, Brown JL, et al
    miR-186 is decreased in aged brain and suppresses BACE1 expression.
    J Neurochem. 2016;137:436-45.
    PubMed     Text format     Abstract available


    April 2016
  33. CARLRED L, Michno W, Kaya I, Sjovall P, et al
    Probing Amyloid-beta Pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI Imaging Mass Spectrometry.
    J Neurochem. 2016 Apr 26. doi: 10.1111/jnc.13645.
    PubMed     Text format     Abstract available


  34. VAN WAALWIJK VAN DOORN LJ, Koel-Simmelink MJ, Haussmann U, Klafki H, et al
    Validation of soluble amyloid-beta precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases.
    J Neurochem. 2016;137:112-21.
    PubMed     Text format     Abstract available


  35. FALKER C, Hartmann A, Guett I, Dohler F, et al
    Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.
    J Neurochem. 2016;137:88-100.
    PubMed     Text format     Abstract available


    March 2016
  36. BEN HALIMA S, Siegel G, Rajendran L
    miR-186 in Alzheimer's disease: a big hope for a small RNA?
    J Neurochem. 2016 Mar 30. doi: 10.1111/jnc.13573.
    PubMed     Text format     Abstract available


  37. CAPPAI R
    'From past to future' - deciphering the molecular basis of Alzheimer's disease through the pages of the Journal of Neurochemistry.
    J Neurochem. 2016 Mar 21. doi: 10.1111/jnc.13546.
    PubMed     Text format     Abstract available


  38. MARCIANI DJ
    A retrospective analysis of the Alzheimer's disease vaccine progress - The critical need for new development strategies.
    J Neurochem. 2016 Mar 15. doi: 10.1111/jnc.13608.
    PubMed     Text format     Abstract available


  39. RYAZANTSEVA M, Skobeleva K, Glushankova L, Kaznacheyeva E, et al
    Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.
    J Neurochem. 2016;136:1085-95.
    PubMed     Text format     Abstract available


    January 2016
  40. SOMAVARAPU AK, Kepp KP
    Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's Disease.
    J Neurochem. 2016 Jan 12. doi: 10.1111/jnc.13535.
    PubMed     Text format     Abstract available


  41. FREEMAN LC, Ting JP
    The pathogenic role of the inflammasome in neurodegenerative diseases.
    J Neurochem. 2016;136 Suppl 1:29-38.
    PubMed     Text format     Abstract available


    December 2015
  42. LEE TH, Park SH, You MH, Lim JH, et al
    A potential therapeutic effect of Saikosaponin C as a novel dual-target anti-Alzheimer agent.
    J Neurochem. 2015 Dec 28. doi: 10.1111/jnc.13515.
    PubMed     Text format     Abstract available


    November 2015
  43. TANG Y, Peng Y, Liu J, Shi L, et al
    Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APP /PSEN1dE9 mouse model of Alzheimer's disease.
    J Neurochem. 2015 Nov 18. doi: 10.1111/jnc.13437.
    PubMed     Text format     Abstract available


  44. GAO L, Tian M, Zhao HY, Xu QQ, et al
    TrkB Activation by 7, 8-Dihydroxyflavone Increases Synapse AMPA Subunits and Ameliorates Spatial Memory Deficits in a Mouse Model of Alzheimer's Disease.
    J Neurochem. 2015 Nov 18. doi: 10.1111/jnc.13432.
    PubMed     Text format     Abstract available


  45. LEE C, Low CY, Francis PT, Attems J, et al
    An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease.
    J Neurochem. 2015 Nov 12. doi: 10.1111/jnc.13429.
    PubMed     Text format     Abstract available


  46. LIAN H, Zheng H
    Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.
    J Neurochem. 2015 Nov 6. doi: 10.1111/jnc.13424.
    PubMed     Text format     Abstract available


  47. BELAIDI AA, Bush AI
    Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics.
    J Neurochem. 2015 Nov 6. doi: 10.1111/jnc.13425.
    PubMed     Text format     Abstract available


  48. ZHANG Q, Wu HH, Wang Y, Gu GJ, et al
    Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer's disease.
    J Neurochem. 2015 Nov 3. doi: 10.1111/jnc.13413.
    PubMed     Text format     Abstract available


    October 2015
  49. MINTER MR, Taylor JM, Crack PJ
    The contribution of neuro-inflammation to amyloid toxicity in Alzheimer's disease.
    J Neurochem. 2015 Oct 28. doi: 10.1111/jnc.13411.
    PubMed     Text format     Abstract available


  50. ISHIKI A, Kamada M, Kawamura Y, Terao C, et al
    Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies and frontotemporal lobar degeneration.
    J Neurochem. 2015 Oct 20. doi: 10.1111/jnc.13399.
    PubMed     Text format     Abstract available


  51. WHITCOMB DJ, Molnar E
    Is riluzole a new drug for Alzheimer's disease?
    J Neurochem. 2015;135:207-9.
    PubMed     Text format     Abstract available


  52. COULSON EJ, Andersen OM
    The A-B-C for SORting APP.
    J Neurochem. 2015;135:1-3.
    PubMed     Text format     Abstract available


  53. CERVELLATI C, Trentini A, Romani A, Bellini T, et al
    Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study.
    J Neurochem. 2015;135:395-401.
    PubMed     Text format     Abstract available


  54. HUNSBERGER HC, Weitzner DS, Rudy CC, Hickman JE, et al
    Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression.
    J Neurochem. 2015;135:381-94.
    PubMed     Text format     Abstract available


  55. XIE C, Soeda Y, Shinzaki Y, In Y, et al
    Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau.
    J Neurochem. 2015;135:19-26.
    PubMed     Text format     Abstract available


  56. HERMEY G, Schmidt N, Bluhm B, Mensching D, et al
    SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.
    J Neurochem. 2015;135:60-75.
    PubMed     Text format     Abstract available


    September 2015
  57. SLEMMON JR, Shapiro A, Mercken M, Streffer J, et al
    Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Abeta42 and influence of disease on the total-Abeta42/Abeta40 ratio.
    J Neurochem. 2015 Sep 1. doi: 10.1111/jnc.13297.
    PubMed     Text format     Abstract available


  58. BAGLIETTO-VARGAS D, Chen Y, Suh D, Ager RR, et al
    Short-term modern life-like stress exacerbates Abeta-pathology and synapse loss in 3xTg-AD mice.
    J Neurochem. 2015;134:915-26.
    PubMed     Text format     Abstract available


  59. SUN LH, Ban T, Liu CD, Chen QX, et al
    Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.
    J Neurochem. 2015;134:1139-51.
    PubMed     Text format     Abstract available


  60. SANTHANAM AV, d'Uscio LV, He T, Das P, et al
    Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.
    J Neurochem. 2015;134:1129-38.
    PubMed     Text format     Abstract available


  61. DE JAGER M, Drukarch B, Hofstee M, Breve J, et al
    Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity.
    J Neurochem. 2015;134:1116-28.
    PubMed     Text format     Abstract available


  62. AKHTER R, Sanphui P, Das H, Saha P, et al
    The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in beta-amyloid-induced neuron death.
    J Neurochem. 2015;134:1091-103.
    PubMed     Text format     Abstract available


    August 2015
  63. IMAMURA O, Arai M, Dateki M, Toru O, et al
    Nicotinic acetylcholine receptors mediate donepezil-induced oligodendrocyte differentiation.
    J Neurochem. 2015 Aug 28. doi: 10.1111/jnc.13294.
    PubMed     Text format     Abstract available


  64. JI B, Chen CJ, Bando K, Ashino H, et al
    Distinct Binding of Amyloid Imaging Ligands to Unique Amyloid-beta Deposited in the Presubiculum of Alzheimer's Disease.
    J Neurochem. 2015 Aug 28. doi: 10.1111/jnc.13293.
    PubMed     Text format     Abstract available


    July 2015
  65. MARCELLO E, Gardoni F, Di Luca M
    Alzheimer's disease and modern lifestyle: what is the role of stress?
    J Neurochem. 2015 Jul 23. doi: 10.1111/jnc.13210.
    PubMed     Text format     Abstract available


  66. POSADA-DUQUE RA, Lopez-Tobon A, Piedrahita D, Gonzalez-Billault C, et al
    p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing.
    J Neurochem. 2015;134:354-70.
    PubMed     Text format     Abstract available


    June 2015
  67. BRUGGINK KA, Kuiperij HB, Gloerich J, Otte-Holler I, et al
    Dickkopf-related protein 3 is a potential Abeta-associated protein in Alzheimer's Disease.
    J Neurochem. 2015 Jun 27. doi: 10.1111/jnc.13216.
    PubMed     Text format     Abstract available


  68. QUAN X, Yue W, Luo Y, Cao J, et al
    The protein arginine methyltransferase PRMT5 regulates Abeta-induced toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease.
    J Neurochem. 2015 Jun 18. doi: 10.1111/jnc.13191.
    PubMed     Text format     Abstract available


    April 2015
  69. LIU XY, Li HL, Su JB, Ding FH, et al
    Regulation of RAGE splicing by hnRNP A1 and Tra2beta-1 and its potential role in AD pathogenesis.
    J Neurochem. 2015;133:187-98.
    PubMed     Text format     Abstract available


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