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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 51 articles:
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Single Articles


    November 2022
  1. CONDELLO C, Maxwell AM, Castillo E, Aoyagi A, et al
    Abeta and tau prions feature in the neuropathogenesis of Down syndrome.
    Proc Natl Acad Sci U S A. 2022;119:e2212954119.
    PubMed     Abstract available


  2. DENG J, Ji Y, Zhu F, Liu L, et al
    Mapping secretome-mediated interaction between paired neuron-macrophage single cells.
    Proc Natl Acad Sci U S A. 2022;119:e2200944119.
    PubMed     Abstract available


    October 2022
  3. DEHGHAN A, Pinto RC, Karaman I, Huang J, et al
    Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2206083119.
    PubMed     Abstract available


  4. WANG X, Rimal S, Tantray I, Geng J, et al
    Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1.
    Proc Natl Acad Sci U S A. 2022;119:e2202322119.
    PubMed     Abstract available


  5. HUANG Y, Lemke G
    Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.
    Proc Natl Acad Sci U S A. 2022;119:e2204306119.
    PubMed     Abstract available


  6. HUANG Y, Rafael Guimaraes T, Todd N, Ferguson C, et al
    G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2204828119.
    PubMed     Abstract available


  7. TIAN J, Ren M, Zhao P, Luo S, et al
    Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain.
    Proc Natl Acad Sci U S A. 2022;119:e2202536119.
    PubMed     Abstract available


    September 2022
  8. ORTI-CASAN N, Zuhorn IS, Naude PJW, De Deyn PP, et al
    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2201137119.
    PubMed     Abstract available


  9. NGIAN ZK, Tan YY, Choo CT, Lin WQ, et al
    Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties.
    Proc Natl Acad Sci U S A. 2022;119:e2204179119.
    PubMed     Abstract available


    August 2022
  10. SAROJA SR, Gorbachev K, Julia T, Goate AM, et al
    Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2022;119:e2108870119.
    PubMed     Abstract available


  11. MURRAY KA, Hu CJ, Griner SL, Pan H, et al
    De novo designed protein inhibitors of amyloid aggregation and seeding.
    Proc Natl Acad Sci U S A. 2022;119:e2206240119.
    PubMed     Abstract available


    June 2022
  12. TAYLOR JL, Pritchard HAT, Walsh KR, Strangward P, et al
    Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204581119.
    PubMed     Abstract available


  13. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
    PubMed     Abstract available


    May 2022
  14. LINSE S, Sormanni P, O'Connell DJ
    An aggregation inhibitor specific to oligomeric intermediates of Abeta42 derived from phage display libraries of stable, small proteins.
    Proc Natl Acad Sci U S A. 2022;119:e2121966119.
    PubMed     Abstract available


  15. ROGERS MA, Chang CCY, Maue RA, Melton EM, et al
    Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
    Proc Natl Acad Sci U S A. 2022;119:e2201646119.
    PubMed     Abstract available


    April 2022
  16. GUZMAN-VELEZ E, Diez I, Schoemaker D, Pardilla-Delgado E, et al
    Amyloid-beta and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2113641119.
    PubMed     Abstract available


    March 2022
  17. JIN C, Wang J, Wang Y, Jia B, et al
    Modulation of amyloid precursor protein cleavage by gamma-secretase activating protein through phase separation.
    Proc Natl Acad Sci U S A. 2022;119:e2122292119.
    PubMed     Abstract available


  18. SHIGEMORI K, Nomura S, Umeda T, Takeda S, et al
    Peripheral Abeta acts as a negative modulator of insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119:e2117723119.
    PubMed     Abstract available


    February 2022
  19. BELSARE KD, Wu H, Mondal D, Bond A, et al
    Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    January 2022
  20. PARK MH, Park KH, Choi BJ, Han WH, et al
    Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    December 2021
  21. MOULTON MJ, Barish S, Ralhan I, Chang J, et al
    Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    November 2021
  22. LATTANZI V, Andre I, Gasser U, Dubackic M, et al
    Amyloid beta 42 fibril structure based on small-angle scattering.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  23. PALMER CR, Liu CS, Romanow WJ, Lee MH, et al
    Altered cell and RNA isoform diversity in aging Down syndrome brains.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  24. GHOSH U, Yau WM, Collinge J, Tycko R, et al
    Structural differences in amyloid-beta fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021

  25. Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  26. PARKHITKO AA, Wang L, Filine E, Jouandin P, et al
    A genetic model of methionine restriction extends Drosophila health- and lifespan.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  27. HOU Y, Wei Y, Lautrup S, Yang B, et al
    NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021

  28. Correction for Sun et al., Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    July 2021
  29. WANG H, Robinson JL, Kocabas P, Gustafsson J, et al
    Genome-scale metabolic network reconstruction of model animals as a platform for translational research.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  30. WU Z, Chen C, Kang SS, Liu X, et al
    Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  31. SADE YAZDI D, Laor Bar-Yosef D, Adsi H, Kreiser T, et al
    Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease beta-amyloid polypeptide.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  32. LORD J, Jermy B, Green R, Wong A, et al
    Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  33. IPPATI S, Deng Y, van der Hoven J, Heu C, et al
    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-beta toxicity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  34. RAMESHA S, Rayaprolu S, Bowen CA, Giver CR, et al
    Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available



  35. Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    January 2021
  36. GHOSH U, Thurber KR, Yau WM, Tycko R, et al
    Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  37. GIOVINAZZO D, Bursac B, Sbodio JI, Nalluru S, et al
    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  38. AHMED F
    QnAs with Robert Tycko.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  39. KIM SH, Yang S, Lim KH, Ko E, et al
    Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  40. ELLWANGER DC, Wang S, Brioschi S, Shao Z, et al
    Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  41. LOHR KM, Frost B, Scherzer C, Feany MB, et al
    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
    Proc Natl Acad Sci U S A. 2020;117:33608-33618.
    PubMed     Abstract available


  42. BOYKO S, Surewicz K, Surewicz WK
    Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.
    Proc Natl Acad Sci U S A. 2020;117:31882-31890.
    PubMed     Abstract available


  43. SWANSON LW, Hahn JD, Sporns O
    Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.
    Proc Natl Acad Sci U S A. 2020;117:31470-31481.
    PubMed     Abstract available


  44. DUBEY S, Heinen S, Krantic S, McLaurin J, et al
    Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Dec 7. pii: 1908658117.
    PubMed     Abstract available


    November 2020
  45. LONNEMANN N, Hosseini S, Marchetti C, Skouras DB, et al
    The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 30. pii: 2009680117.
    PubMed     Abstract available


  46. CHO HJ, Huynh TT, Rogers BE, Mirica LM, et al
    Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 24. pii: 2014058117.
    PubMed     Abstract available


  47. ENGSTROM AK, Walker AC, Moudgal RA, Myrick DA, et al
    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:29133-29143.
    PubMed     Abstract available


    October 2020

  48. Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Oct 26. pii: 2019837117.
    PubMed    


    September 2020
  49. LAU SF, Cao H, Fu AKY, Ip NY, et al
    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 28. pii: 2008762117.
    PubMed     Abstract available


    August 2020
  50. O'CONNELL GC, Alder ML, Smothers CG, Chang JHC, et al
    Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage.
    Proc Natl Acad Sci U S A. 2020;117:20764-20775.
    PubMed     Abstract available


  51. CHAKRABORTY D, Straub JE, Thirumalai D
    Differences in the free energies between the excited states of Abeta40 and Abeta42 monomers encode their aggregation propensities.
    Proc Natl Acad Sci U S A. 2020;117:19926-19937.
    PubMed     Abstract available


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