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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 64 articles:
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Single Articles


    June 2022
  1. TAYLOR JL, Pritchard HAT, Walsh KR, Strangward P, et al
    Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204581119.
    PubMed     Abstract available


  2. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
    PubMed     Abstract available


    May 2022
  3. LINSE S, Sormanni P, O'Connell DJ
    An aggregation inhibitor specific to oligomeric intermediates of Abeta42 derived from phage display libraries of stable, small proteins.
    Proc Natl Acad Sci U S A. 2022;119:e2121966119.
    PubMed     Abstract available


  4. ROGERS MA, Chang CCY, Maue RA, Melton EM, et al
    Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
    Proc Natl Acad Sci U S A. 2022;119:e2201646119.
    PubMed     Abstract available


    April 2022
  5. GUZMAN-VELEZ E, Diez I, Schoemaker D, Pardilla-Delgado E, et al
    Amyloid-beta and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2113641119.
    PubMed     Abstract available


    March 2022
  6. JIN C, Wang J, Wang Y, Jia B, et al
    Modulation of amyloid precursor protein cleavage by gamma-secretase activating protein through phase separation.
    Proc Natl Acad Sci U S A. 2022;119:e2122292119.
    PubMed     Abstract available


  7. SHIGEMORI K, Nomura S, Umeda T, Takeda S, et al
    Peripheral Abeta acts as a negative modulator of insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119:e2117723119.
    PubMed     Abstract available


    February 2022
  8. BELSARE KD, Wu H, Mondal D, Bond A, et al
    Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    January 2022
  9. PARK MH, Park KH, Choi BJ, Han WH, et al
    Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    December 2021
  10. MOULTON MJ, Barish S, Ralhan I, Chang J, et al
    Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    November 2021
  11. LATTANZI V, Andre I, Gasser U, Dubackic M, et al
    Amyloid beta 42 fibril structure based on small-angle scattering.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  12. PALMER CR, Liu CS, Romanow WJ, Lee MH, et al
    Altered cell and RNA isoform diversity in aging Down syndrome brains.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  13. GHOSH U, Yau WM, Collinge J, Tycko R, et al
    Structural differences in amyloid-beta fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021

  14. Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  15. PARKHITKO AA, Wang L, Filine E, Jouandin P, et al
    A genetic model of methionine restriction extends Drosophila health- and lifespan.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  16. HOU Y, Wei Y, Lautrup S, Yang B, et al
    NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021

  17. Correction for Sun et al., Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    July 2021
  18. WANG H, Robinson JL, Kocabas P, Gustafsson J, et al
    Genome-scale metabolic network reconstruction of model animals as a platform for translational research.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  19. WU Z, Chen C, Kang SS, Liu X, et al
    Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  20. SADE YAZDI D, Laor Bar-Yosef D, Adsi H, Kreiser T, et al
    Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease beta-amyloid polypeptide.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  21. LORD J, Jermy B, Green R, Wong A, et al
    Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  22. IPPATI S, Deng Y, van der Hoven J, Heu C, et al
    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-beta toxicity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  23. RAMESHA S, Rayaprolu S, Bowen CA, Giver CR, et al
    Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available



  24. Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    January 2021
  25. GHOSH U, Thurber KR, Yau WM, Tycko R, et al
    Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  26. GIOVINAZZO D, Bursac B, Sbodio JI, Nalluru S, et al
    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  27. AHMED F
    QnAs with Robert Tycko.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  28. KIM SH, Yang S, Lim KH, Ko E, et al
    Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  29. ELLWANGER DC, Wang S, Brioschi S, Shao Z, et al
    Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  30. LOHR KM, Frost B, Scherzer C, Feany MB, et al
    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
    Proc Natl Acad Sci U S A. 2020;117:33608-33618.
    PubMed     Abstract available


  31. BOYKO S, Surewicz K, Surewicz WK
    Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.
    Proc Natl Acad Sci U S A. 2020;117:31882-31890.
    PubMed     Abstract available


  32. SWANSON LW, Hahn JD, Sporns O
    Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.
    Proc Natl Acad Sci U S A. 2020;117:31470-31481.
    PubMed     Abstract available


  33. DUBEY S, Heinen S, Krantic S, McLaurin J, et al
    Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Dec 7. pii: 1908658117.
    PubMed     Abstract available


    November 2020
  34. LONNEMANN N, Hosseini S, Marchetti C, Skouras DB, et al
    The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 30. pii: 2009680117.
    PubMed     Abstract available


  35. CHO HJ, Huynh TT, Rogers BE, Mirica LM, et al
    Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 24. pii: 2014058117.
    PubMed     Abstract available


  36. ENGSTROM AK, Walker AC, Moudgal RA, Myrick DA, et al
    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:29133-29143.
    PubMed     Abstract available


    October 2020

  37. Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Oct 26. pii: 2019837117.
    PubMed    


    September 2020
  38. LAU SF, Cao H, Fu AKY, Ip NY, et al
    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 28. pii: 2008762117.
    PubMed     Abstract available


    August 2020
  39. O'CONNELL GC, Alder ML, Smothers CG, Chang JHC, et al
    Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage.
    Proc Natl Acad Sci U S A. 2020;117:20764-20775.
    PubMed     Abstract available


  40. CHAKRABORTY D, Straub JE, Thirumalai D
    Differences in the free energies between the excited states of Abeta40 and Abeta42 monomers encode their aggregation propensities.
    Proc Natl Acad Sci U S A. 2020;117:19926-19937.
    PubMed     Abstract available


    July 2020
  41. PEEPLES L
    Inner Workings: A pulse of hope in the fight against Alzheimer's.
    Proc Natl Acad Sci U S A. 2020 Jul 15. pii: 2013084117.
    PubMed    


    June 2020
  42. APRILE FA, Sormanni P, Podpolny M, Chhangur S, et al
    Rational design of a conformation-specific antibody for the quantification of Abeta oligomers.
    Proc Natl Acad Sci U S A. 2020;117:13509-13518.
    PubMed     Abstract available


  43. DEAR AJ, Michaels TCT, Meisl G, Klenerman D, et al
    Kinetic diversity of amyloid oligomers.
    Proc Natl Acad Sci U S A. 2020;117:12087-12094.
    PubMed     Abstract available


    May 2020
  44. TORNQUIST M, Cukalevski R, Weininger U, Meisl G, et al
    Ultrastructural evidence for self-replication of Alzheimer-associated Abeta42 amyloid along the sides of fibrils.
    Proc Natl Acad Sci U S A. 2020;117:11265-11273.
    PubMed     Abstract available


    April 2020
  45. REZAI AR, Ranjan M, D'Haese PF, Haut MW, et al
    Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound.
    Proc Natl Acad Sci U S A. 2020 Apr 13. pii: 2002571117.
    PubMed     Abstract available


  46. WERNER ER, Keller MA, Sailer S, Lackner K, et al
    The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.
    Proc Natl Acad Sci U S A. 2020;117:7792-7798.
    PubMed     Abstract available


    March 2020
  47. CENDROWSKA U, Silva PJ, Ait-Bouziad N, Muller M, et al
    Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.
    Proc Natl Acad Sci U S A. 2020;117:6866-6874.
    PubMed     Abstract available


  48. WELIKOVITCH LA, Do Carmo S, Magloczky Z, Malcolm JC, et al
    Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
    Proc Natl Acad Sci U S A. 2020;117:6844-6854.
    PubMed     Abstract available


  49. WOO JA, Liu T, Fang CC, Castano MA, et al
    beta-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates.
    Proc Natl Acad Sci U S A. 2020;117:5006-5015.
    PubMed     Abstract available


  50. CHOI JH, Han J, Theodoropoulos PC, Zhong X, et al
    Essential requirement for nicastrin in marginal zone and B-1 B cell development.
    Proc Natl Acad Sci U S A. 2020;117:4894-4901.
    PubMed     Abstract available


    February 2020
  51. SEN T, Saha P, Jiang T, Sen N, et al
    Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 12. pii: 1916895117.
    PubMed     Abstract available


  52. PENG J, Zhao T
    Reduction in TOM1 expression exacerbates Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 1917589117.
    PubMed    


  53. MARTINI AC, Baglietto-Vargas D, Medeiros R, LaFerla FM, et al
    Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 1917743117.
    PubMed    


    December 2019
  54. HAQUE RU, Levey AI
    Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1912954116.
    PubMed     Abstract available


  55. ARNSTEN AFT, Datta D, Leslie S, Yang ST, et al
    Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1903671116.
    PubMed     Abstract available



  56. Correction for Wang et al., Spatiotemporal activation of the C/EBPbeta/delta-secretase axis regulates the pathogenesis of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 1920626117.
    PubMed    


    November 2019
  57. AIKAWA T, Ren Y, Yamazaki Y, Tachibana M, et al
    ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
    Proc Natl Acad Sci U S A. 2019;116:23790-23796.
    PubMed     Abstract available


  58. PARK MH, Lee M, Nam G, Kim M, et al
    N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice.
    Proc Natl Acad Sci U S A. 2019 Nov 4. pii: 1916318116.
    PubMed     Abstract available


    October 2019
  59. CHEN ZL, Singh P, Wong J, Horn K, et al
    An antibody against HK blocks Alzheimer's disease peptide beta-amyloid-induced bradykinin release in human plasma.
    Proc Natl Acad Sci U S A. 2019 Oct 28. pii: 1914831116.
    PubMed     Abstract available


  60. SHARMA A, Kazim SF, Larson CS, Ramakrishnan A, et al
    Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.
    Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 1903566116.
    PubMed     Abstract available


    August 2019
  61. LOPEZ T, Mustafa Z, Chen C, Lee KB, et al
    Functional selection of protease inhibitory antibodies.
    Proc Natl Acad Sci U S A. 2019;116:16314-16319.
    PubMed     Abstract available


  62. DREGNI AJ, Mandala VS, Wu H, Elkins MR, et al
    In vitro 0N4R tau fibrils contain a monomorphic beta-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.
    Proc Natl Acad Sci U S A. 2019;116:16357-16366.
    PubMed     Abstract available


    July 2019
  63. MICHAELS TCT, Weber CA, Mahadevan L
    Optimal control strategies for inhibition of protein aggregation.
    Proc Natl Acad Sci U S A. 2019;116:14593-14598.
    PubMed     Abstract available


    June 2019
  64. HU ZW, Vugmeyster L, Au DF, Ostrovsky D, et al
    Molecular structure of an N-terminal phosphorylated beta-amyloid fibril.
    Proc Natl Acad Sci U S A. 2019;116:11253-11258.
    PubMed     Abstract available


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