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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 51 articles:
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    May 2018
  1. CALLENDER JA, Yang Y, Lorden G, Stephenson NL, et al
    Protein kinase Calpha gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.
    Proc Natl Acad Sci U S A. 2018 May 29. pii: 1805046115.
    PubMed     Text format     Abstract available


    March 2018
  2. ADLER DH, Wisse LEM, Ittyerah R, Pluta JB, et al
    Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology.
    Proc Natl Acad Sci U S A. 2018 Mar 28. pii: 1801093115.
    PubMed     Text format     Abstract available


  3. BAO J, Qin M, Mahaman YAR, Zhang B, et al
    BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 1800498115.
    PubMed     Text format     Abstract available


  4. LORENZI M, Altmann A, Gutman B, Wray S, et al
    Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics.
    Proc Natl Acad Sci U S A. 2018 Mar 6. pii: 1706100115.
    PubMed     Text format     Abstract available


    February 2018
  5. ZHOU HH, Singh V, Johnson SC, Wahba G, et al
    Statistical tests and identifiability conditions for pooling and analyzing multisite datasets.
    Proc Natl Acad Sci U S A. 2018;115:1481-1486.
    PubMed     Text format     Abstract available


  6. ZHOU X, Chen Y, Mok KY, Zhao Q, et al
    Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2018 Feb 5. pii: 1715554115.
    PubMed     Text format     Abstract available


  7. HOU Y, Lautrup S, Cordonnier S, Wang Y, et al
    NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
    Proc Natl Acad Sci U S A. 2018 Feb 5. pii: 1718819115.
    PubMed     Text format     Abstract available


    January 2018
  8. LERDKRAI C, Asavapanumas N, Brawek B, Kovalchuk Y, et al
    Intracellular Ca(2+) stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 22. pii: 1714409115.
    PubMed     Text format     Abstract available


  9. BENNETT RE, Robbins AB, Hu M, Cao X, et al
    Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 22. pii: 1710329115.
    PubMed     Text format     Abstract available


  10. HAN KH, Arlian BM, Macauley MS, Paulson JC, et al
    Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid beta.
    Proc Natl Acad Sci U S A. 2018;115:E372-E381.
    PubMed     Text format     Abstract available


  11. CONDELLO C, Lemmin T, Stohr J, Nick M, et al
    Structural heterogeneity and intersubject variability of Abeta in familial and sporadic Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 8. pii: 1714966115.
    PubMed     Text format     Abstract available


  12. CHEN C, Wang Z, Zhang Z, Liu X, et al
    The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2018 Jan 2. pii: 1718683115.
    PubMed     Text format     Abstract available


    November 2017
  13. RASMUSSEN J, Mahler J, Beschorner N, Kaeser SA, et al
    Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Nov 20. pii: 201713215.
    PubMed     Text format     Abstract available


  14. YANG J, Zhang X, Yuan P, Yang J, et al
    Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Nov 6. pii: 201706248.
    PubMed     Text format     Abstract available


    October 2017
  15. VOLMAR CH, Salah-Uddin H, Janczura KJ, Halley P, et al
    M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.
    Proc Natl Acad Sci U S A. 2017;114:E9135-E9144.
    PubMed     Text format     Abstract available


  16. ANDREW RJ, Fernandez CG, Stanley M, Jiang H, et al
    Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 23. pii: 201708568.
    PubMed     Text format     Abstract available


  17. MANO T, Nagata K, Nonaka T, Tarutani A, et al
    Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 17. pii: 201707151.
    PubMed     Text format     Abstract available


  18. RUBINSZTEIN DC
    RIPK1 promotes inflammation and beta-amyloid accumulation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201715241.
    PubMed     Text format    


    September 2017
  19. OFENGEIM D, Mazzitelli S, Ito Y, DeWitt JP, et al
    RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Sep 13. pii: 201714175.
    PubMed     Text format     Abstract available


  20. PARASKEVAIDI M, Morais CLM, Lima KMG, Snowden JS, et al
    Differential diagnosis of Alzheimer's disease using spectrochemical analysis of blood.
    Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201701517.
    PubMed     Text format     Abstract available


    July 2017
  21. KESKIN AD, Kekus M, Adelsberger H, Neumann U, et al
    BACE inhibition-dependent repair of Alzheimer's pathophysiology.
    Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708106.
    PubMed     Text format     Abstract available


    June 2017
  22. KUNDRA R, Ciryam P, Morimoto RI, Dobson CM, et al
    Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201618417.
    PubMed     Text format     Abstract available


    May 2017
  23. LI Q, Navakkode S, Rothkegel M, Soong TW, et al
    Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 May 8. pii: 201613700.
    PubMed     Text format     Abstract available


    March 2017
  24. WANG BJ, Her GM, Hu MK, Chen YW, et al
    ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 28. pii: 201618804.
    PubMed     Text format     Abstract available


  25. ZHANG Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, et al
    Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
    Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201615036.
    PubMed     Text format     Abstract available


    January 2017
  26. PERANI D, Farsad M, Ballarini T, Lubian F, et al
    The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia.
    Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201610909.
    PubMed     Text format     Abstract available


  27. KELLEHER RJ 3RD, Shen J
    Presenilin-1 mutations and Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Jan 12. pii: 201619574.
    PubMed     Text format    


    December 2016
  28. HABCHI J, Chia S, Limbocker R, Mannini B, et al
    Systematic development of small molecules to inhibit specific microscopic steps of Abeta42 aggregation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2016 Dec 23. pii: 201615613.
    PubMed     Text format     Abstract available


    November 2016
  29. WOERMAN AL, Aoyagi A, Patel S, Kazmi SA, et al
    Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.
    Proc Natl Acad Sci U S A. 2016 Nov 28. pii: 201616344.
    PubMed     Text format     Abstract available


    October 2016
  30. KATSOURI L, Lim YM, Blondrath K, Eleftheriadou I, et al
    PPARgamma-coactivator-1alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model.
    Proc Natl Acad Sci U S A. 2016;113:12292-12297.
    PubMed     Text format     Abstract available


  31. ZHANG X, Mormino EC, Sun N, Sperling RA, et al
    Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2016 Oct 4. pii: 201611073.
    PubMed     Text format     Abstract available


    August 2016
  32. EISENBERG DS, Sawaya MR
    Implications for Alzheimer's disease of an atomic resolution structure of amyloid-beta(1-42) fibrils.
    Proc Natl Acad Sci U S A. 2016 Aug 9. pii: 201610806.
    PubMed     Text format    


    April 2016
  33. BETTAYEB K, Hooli BV, Parrado AR, Randolph L, et al
    Relevance of the COPI complex for Alzheimer's disease progression in vivo.
    Proc Natl Acad Sci U S A. 2016 Apr 25. pii: 201604176.
    PubMed     Text format     Abstract available


  34. FU AK, Hung KW, Yuen MY, Zhou X, et al
    IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
    Proc Natl Acad Sci U S A. 2016 Apr 18. pii: 201604032.
    PubMed     Text format     Abstract available


  35. CIRYAM P, Kundra R, Freer R, Morimoto RI, et al
    A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.
    Proc Natl Acad Sci U S A. 2016 Apr 11. pii: 201516604.
    PubMed     Text format     Abstract available


  36. PINOTSI D, Michel CH, Buell AK, Laine RF, et al
    Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
    Proc Natl Acad Sci U S A. 2016;113:3815-9.
    PubMed     Text format     Abstract available


    March 2016
  37. SENEVIRATNE U, Nott A, Bhat VB, Ravindra KC, et al
    S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.
    Proc Natl Acad Sci U S A. 2016 Mar 24. pii: 201521318.
    PubMed     Text format     Abstract available


  38. SPRINGER SA, Schwarz F, Altheide TK, Varki NM, et al
    Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness.
    Proc Natl Acad Sci U S A. 2016;113:E1591-2.
    PubMed     Text format    


  39. LIU G, Jiang Q
    Alzheimer's disease CD33 rs3865444 variant does not contribute to cognitive performance.
    Proc Natl Acad Sci U S A. 2016 Mar 1. pii: 201600852.
    PubMed     Text format    


    February 2016
  40. MARSH SE, Abud EM, Lakatos A, Karimzadeh A, et al
    The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function.
    Proc Natl Acad Sci U S A. 2016 Feb 16. pii: 201525466.
    PubMed     Text format     Abstract available


    January 2016
  41. URBAN S
    Nicastrin guards Alzheimer's gate.
    Proc Natl Acad Sci U S A. 2016 Jan 25. pii: 201524151.
    PubMed     Text format    


  42. HAWKES K
    Genomic evidence for the evolution of human postmenopausal longevity.
    Proc Natl Acad Sci U S A. 2016;113:17-8.
    PubMed     Text format    


  43. SCHWARZ F, Springer SA, Altheide TK, Varki NM, et al
    Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.
    Proc Natl Acad Sci U S A. 2016;113:74-9.
    PubMed     Text format     Abstract available


    September 2015
  44. ZHU L, Zhong M, Elder GA, Sano M, et al
    Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2015 Sep 8. pii: 201510011.
    PubMed     Text format     Abstract available


    July 2015
  45. OHNISHI T, Yanazawa M, Sasahara T, Kitamura Y, et al
    Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly.
    Proc Natl Acad Sci U S A. 2015 Jul 29. pii: 201421182.
    PubMed     Text format     Abstract available


  46. ZHANG X, Tian Y, Zhang C, Tian X, et al
    Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2015 Jul 21. pii: 201505420.
    PubMed     Text format     Abstract available


  47. CORBETT GT, Gonzalez FJ, Pahan K
    Activation of peroxisome proliferator-activated receptor alpha stimulates ADAM10-mediated proteolysis of APP.
    Proc Natl Acad Sci U S A. 2015;112:8445-50.
    PubMed     Text format     Abstract available


    June 2015
  48. GOWRISHANKAR S, Yuan P, Wu Y, Schrag M, et al
    Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.
    Proc Natl Acad Sci U S A. 2015 Jun 29. pii: 201510329.
    PubMed     Text format     Abstract available


    May 2015
  49. SUN L, Zhao L, Yang G, Yan C, et al
    Structural basis of human gamma-secretase assembly.
    Proc Natl Acad Sci U S A. 2015;112:6003-8.
    PubMed     Text format     Abstract available


    April 2015
  50. ABELEIN A, Graslund A, Danielsson J
    Zinc as chaperone-mimicking agent for retardation of amyloid beta peptide fibril formation.
    Proc Natl Acad Sci U S A. 2015;112:5407-12.
    PubMed     Text format     Abstract available


  51. BARRIO JR, Small GW, Wong KP, Huang SC, et al
    In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.
    Proc Natl Acad Sci U S A. 2015 Apr 6. pii: 201409952.
    PubMed     Text format     Abstract available


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