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Alzheimer's Disease

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 75 articles: HTML format

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December 2025
1. WAGH AR, Glickman MH
   Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant UBB(+1).
   Proc Natl Acad Sci U S A. 2025;122:e2504528122.
   PubMed     Abstract available
   
   
   November 2025
2. AKHTER F, Akhter A, Zhu X, Schiff H, et al
   Amyloid-beta glycation induces neuronal mitochondrial dysfunction and Alzheimer's pathogenesis via VDAC1-dependent mtDNA efflux.
   Proc Natl Acad Sci U S A. 2025;122:e2505046122.
   PubMed     Abstract available
   
   
   
3. ULKU I, Ansari FE, Hancock MA, Zhou H, et al
   Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Abeta degradation pathway.
   Proc Natl Acad Sci U S A. 2025;122:e2507450122.
   PubMed     Abstract available
   
   
   
4. ARAGONES PEDROLA J, Dekker FA, Garfagnini T, Mayer G, et al
   FibrilPaint to determine the length of Tau amyloids in fluids.
   Proc Natl Acad Sci U S A. 2025;122:e2502847122.
   PubMed     Abstract available
   
   
   
5. WEARN A, Tardif CL, Leppert IR, Baracchini G, et al
   Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology.
   Proc Natl Acad Sci U S A. 2025;122:e2502674122.
   PubMed     Abstract available
   
   
   October 2025
6. ZHAO R, Sophanpanichkul P, Chadarevian JP, Ding Y, et al
   Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release.
   Proc Natl Acad Sci U S A. 2025;122:e2509903122.
   PubMed     Abstract available
   
   
   
7. RAVNDAL A, Fjell AM, Vidal-Pineiro D, Sorensen O, et al
   Sex differences in healthy brain aging are unlikely to explain higher Alzheimer's disease prevalence in women.
   Proc Natl Acad Sci U S A. 2025;122:e2510486122.
   PubMed     Abstract available
   
   
   
8. STANTON AE, Bubnys A, Agbas E, James B, et al
   Engineered 3D immuno-glial-neurovascular human miBrain model.
   Proc Natl Acad Sci U S A. 2025;122:e2511596122.
   PubMed     Abstract available
   
   
   September 2025
9. MCKAY CE, Deans M, Connor J, Saunders JC, et al
   Employing deep mutational scanning in the Escherichia coli periplasm to decode the thermodynamic landscape for amyloid formation.
   Proc Natl Acad Sci U S A. 2025;122:e2516165122.
   PubMed     Abstract available
   
   
   
10. BROTT BK, Raissi AJ, Micheva KD, Vielmetter J, et al
    C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruning.
    Proc Natl Acad Sci U S A. 2025;122:e2519253122.
    PubMed     Abstract available
    
    
    
11. DONG Z, Yin T, Deng Z, Zou H, et al
    Hybridoma-inspired strategy crafts tailored multifunctional exosomes for precision therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2424547122.
    PubMed     Abstract available
    
    
    
12. VERDUZCO ESPINOZA AP, Na N, Campanati L, Ngo P, et al
    Microglia-to-neuron signaling links APOE4 and inflammation to enhanced neuronal lipid metabolism and network activity.
    Proc Natl Acad Sci U S A. 2025;122:e2516103122.
    PubMed     Abstract available
    
    
    
13. ZHANG Y, Chen-Engerer HJ, Zhang K, Zott B, et al
    Amyloid beta-dependent neuronal silencing through synaptic decoupling.
    Proc Natl Acad Sci U S A. 2025;122:e2515113122.
    PubMed     Abstract available
    
    
    August 2025
14. FRUITMAN DAVIDI A, Shirenova S, Michaelovich D, Benedetti G, et al
    Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases.
    Proc Natl Acad Sci U S A. 2025;122:e2425081122.
    PubMed     Abstract available
    
    
    
15. LEE J, Lee B, Lee H, Kim EJE, et al
    Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.
    Proc Natl Acad Sci U S A. 2025;122:e2505217122.
    PubMed     Abstract available
    
    
    July 2025
16. BEERENDONK L, Mejias JF, Nuiten SA, de Gee JW, et al
    Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.
    Proc Natl Acad Sci U S A. 2025;122:e2419733122.
    PubMed     Abstract available
    
    
    
17. FALLOT LB, Pinc JR, Buselmeier JE, Palchak JC, et al
    An aminosterol breaks the autocatalytic cycle of Abeta(42) aggregation and protects cell membranes from its soluble aggregates.
    Proc Natl Acad Sci U S A. 2025;122:e2417944122.
    PubMed     Abstract available
    
    
    June 2025
18. TIAN L, Long G, Zhu S, Wang Y, et al
    Nanoimmunomodulation of the Abeta-STING feedback machinery in microglia for Alzheimer's disease treatment.
    Proc Natl Acad Sci U S A. 2025;122:e2427257122.
    PubMed     Abstract available
    
    
    May 2025
19. 
    Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2509530122.
    PubMed    
    
    
    
20. KOH Y, Vazquez-Rosa E, Gao F, Li H, et al
    Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.
    Proc Natl Acad Sci U S A. 2025;122:e2417224122.
    PubMed     Abstract available
    
    
    
21. CHEN W, Liu X, Munoz VR, Kahn CR, et al
    Loss of insulin signaling in microglia impairs cellular uptake of Abeta and neuroinflammatory response exacerbating AD-like neuropathology.
    Proc Natl Acad Sci U S A. 2025;122:e2501527122.
    PubMed     Abstract available
    
    
    April 2025
22. PAULSON AL, Zhang L, Prichard AM, Singer AC, et al
    40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2419364122.
    PubMed     Abstract available
    
    
    March 2025
23. YIN C, Imms P, Chowdhury NF, Chaudhari NN, et al
    Deep learning to quantify the pace of brain aging in relation to neurocognitive changes.
    Proc Natl Acad Sci U S A. 2025;122:e2413442122.
    PubMed     Abstract available
    
    
    
24. JOHNSON EA, Nowar R, Viola KL, Huang W, et al
    Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism for the treatment of neurodegenerative diseases.
    Proc Natl Acad Sci U S A. 2025;122:e2402117122.
    PubMed     Abstract available
    
    
    
25. ZHANG X, Vlkolinsky R, Wu C, Dolatabadi N, et al
    S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity.
    Proc Natl Acad Sci U S A. 2025;122:e2418179122.
    PubMed     Abstract available
    
    
    February 2025
26. NGUYEN L, Ajredini R, Guo S, Romano LEL, et al
    CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk.
    Proc Natl Acad Sci U S A. 2025;122:e2416885122.
    PubMed     Abstract available
    
    
    
27. YANG X, Wang Y, Qiao Y, Lin J, et al
    Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2420324122.
    PubMed     Abstract available
    
    
    
28. JIANG WI, Cao Y, Xue Y, Ji Y, et al
    Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.
    Proc Natl Acad Sci U S A. 2025;122:e2417515122.
    PubMed     Abstract available
    
    
    January 2025
29. SNEIDERIENE G, Gonzalez Diaz A, Adhikari SD, Wei J, et al
    Lipid-induced condensate formation from the Alzheimer's Abeta peptide triggers amyloid aggregation.
    Proc Natl Acad Sci U S A. 2025;122:e2401307122.
    PubMed     Abstract available
    
    
    December 2024
30. CHAKRABORTY P, Ibanez de Opakua A, Purslow JA, Fromm SA, et al
    GSK3beta phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.
    Proc Natl Acad Sci U S A. 2024;121:e2414176121.
    PubMed     Abstract available
    
    
    
31. NATALE F, Spinelli M, Rinaudo M, Gulisano W, et al
    Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2402604121.
    PubMed     Abstract available
    
    
    
32. KRISTENSEN M
    Insulin-inspired peptides may open new pathways to treat Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2419741121.
    PubMed    
    
    
    October 2024
33. KAMEI N, Ikeda K, Ohmoto Y, Fujisaki S, et al
    Insulin-inspired hippocampal neuron-targeting technology for protein drug delivery.
    Proc Natl Acad Sci U S A. 2024;121:e2407936121.
    PubMed     Abstract available
    
    
    September 2024
34. SATO K, Takayama KI, Saito Y, Inoue S, et al
    ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
    Proc Natl Acad Sci U S A. 2024;121:e2406854121.
    PubMed     Abstract available
    
    
    
35. ZHANG N, Zhang R, Jiang L, Gao Z, et al
    Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance.
    Proc Natl Acad Sci U S A. 2024;121:e2314337121.
    PubMed     Abstract available
    
    
    
36. JENSEN AMG, Raska J, Fojtik P, Monti G, et al
    The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2408262121.
    PubMed     Abstract available
    
    
    August 2024
37. 
    Retraction for Janczura et al., Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.
    Proc Natl Acad Sci U S A. 2024;121:e2415279121.
    PubMed    
    
    
    
38. YAN K, Zhang C, Kang J, Montenegro P, et al
    Cortical neurodegeneration caused by Psen1 mutations is independent of Abeta.
    Proc Natl Acad Sci U S A. 2024;121:e2409343121.
    PubMed     Abstract available
    
    
    
39. FRANK M, Ni P, Jensen M, Gerstein MB, et al
    Leveraging a large language model to predict protein phase transition: A physical, multiscale, and interpretable approach.
    Proc Natl Acad Sci U S A. 2024;121:e2320510121.
    PubMed     Abstract available
    
    
    
40. WEI X, Campagna JJ, Jagodzinska B, Wi D, et al
    A therapeutic small molecule enhances gamma-oscillations and improves cognition/memory in Alzheimer's disease model mice.
    Proc Natl Acad Sci U S A. 2024;121:e2400420121.
    PubMed     Abstract available
    
    
    
41. PLASCENCIA-VILLA G, Castellani RJ, Perry G
    Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2412255121.
    PubMed    
    
    
    July 2024
42. PANWAR A, Rentsendorj A, Jhun M, Cohen RM, et al
    Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration.
    Proc Natl Acad Sci U S A. 2024;121:e2401420121.
    PubMed     Abstract available
    
    
    
43. MALAQUIN S, Lerchundi R, Mougel E, Valette J, et al
    Capturing alterations of intracellular-extracellular lactate distribution in the brain using diffusion-weighted MR spectroscopy in vivo.
    Proc Natl Acad Sci U S A. 2024;121:e2403635121.
    PubMed     Abstract available
    
    
    June 2024
44. AXELL E, Hu J, Lindberg M, Dear AJ, et al
    The role of shear forces in primary and secondary nucleation of amyloid fibrils.
    Proc Natl Acad Sci U S A. 2024;121:e2322572121.
    PubMed     Abstract available
    
    
    May 2024
45. TURNER GR, Hewan P, Wearn A, van Dooren R, et al
    Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.
    Proc Natl Acad Sci U S A. 2024;121:e2322617121.
    PubMed     Abstract available
    
    
    April 2024
46. SINGH PK, Simoes-Pires EN, Chen ZL, Torrente D, et al
    Lecanemab blocks the effects of the Abeta/fibrinogen complex on blood clots and synapse toxicity in organotypic culture.
    Proc Natl Acad Sci U S A. 2024;121:e2314450121.
    PubMed     Abstract available
    
    
    March 2024
47. MAMMERI NE, Dregni AJ, Duan P, Hong M, et al
    Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation.
    Proc Natl Acad Sci U S A. 2024;121:e2316175121.
    PubMed     Abstract available
    
    
    December 2023
48. ZHANG H, Chen Y, Yu M, Xi Y, et al
    Nasal delivery of polymeric nanoDisc mobilizes a synergy of central and peripheral amyloid-beta clearance to treat Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2304213120.
    PubMed     Abstract available
    
    
    
49. WANG W, Ma X, Bhatta S, Shao C, et al
    Intraneuronal beta-amyloid impaired mitochondrial proteostasis through the impact on LONP1.
    Proc Natl Acad Sci U S A. 2023;120:e2316823120.
    PubMed     Abstract available
    
    
    
50. ZHANG J, Wickizer C, Ding W, Van R, et al
    In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.
    Proc Natl Acad Sci U S A. 2023;120:e2310131120.
    PubMed     Abstract available
    
    
    November 2023
51. BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al
    In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.
    Proc Natl Acad Sci U S A. 2023;120:e2311565120.
    PubMed     Abstract available
    
    
    
52. NIERE F, Uneri A, McArdle CJ, Deng Z, et al
    Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2301534120.
    PubMed     Abstract available
    
    
    October 2023
53. DUAN P, Dregni AJ, Mammeri NE, Hong M, et al
    Structure of the nonhelical filament of the Alzheimer's disease tau core.
    Proc Natl Acad Sci U S A. 2023;120:e2310067120.
    PubMed     Abstract available
    
    
    
54. MONTENEGRO P, Chen P, Kang J, Lee SH, et al
    Human Presenilin-1 delivered by AAV9 rescues impaired gamma-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice.
    Proc Natl Acad Sci U S A. 2023;120:e2306714120.
    PubMed     Abstract available
    
    
    
55. ABSKHARON R, Pan H, Sawaya MR, Seidler PM, et al
    Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
    Proc Natl Acad Sci U S A. 2023;120:e2300258120.
    PubMed     Abstract available
    
    
    
56. LU K, Li C, Liu J, Wang J, et al
    Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice.
    Proc Natl Acad Sci U S A. 2023;120:e2303878120.
    PubMed     Abstract available
    
    
    
57. LIM CM, Gonzalez Diaz A, Fuxreiter M, Pun FW, et al
    Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.
    Proc Natl Acad Sci U S A. 2023;120:e2300215120.
    PubMed     Abstract available
    
    
    September 2023
58. LOPES JR, Zhang X, Mayrink J, Tatematsu BK, et al
    Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309221120.
    PubMed     Abstract available
    
    
    
59. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
    PubMed     Abstract available
    
    
    
60. CHEN ZL, Singh PK, Calvano M, Norris EH, et al
    A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309389120.
    PubMed     Abstract available
    
    
    August 2023
61. SOULA M, Maslarova A, Harvey RE, Valero M, et al
    Interictal epileptiform discharges affect memory in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2302676120.
    PubMed     Abstract available
    
    
    
62. NAKANO-KOBAYASHI A, Canela A, Yoshihara T, Hagiwara M, et al
    Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
    Proc Natl Acad Sci U S A. 2023;120:e2303809120.
    PubMed     Abstract available
    
    
    July 2023
63. CAZZARO S, Woo JA, Wang X, Liu T, et al
    Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2217128120.
    PubMed     Abstract available
    
    
    June 2023
64. THACKER D, Barghouth M, Bless M, Zhang E, et al
    Direct observation of secondary nucleation along the fibril surface of the amyloid beta 42 peptide.
    Proc Natl Acad Sci U S A. 2023;120:e2220664120.
    PubMed     Abstract available
    
    
    
65. ENNERFELT H, Holliday C, Shapiro DA, Zengeler KE, et al
    CARD9 attenuates Abeta pathology and modifies microglial responses in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2303760120.
    PubMed     Abstract available
    
    
    May 2023
66. KREUTZER AG, Guaglianone G, Yoo S, Parrocha CMT, et al
    Probing differences among Abeta oligomers with two triangular trimers derived from Abeta.
    Proc Natl Acad Sci U S A. 2023;120:e2219216120.
    PubMed     Abstract available
    
    
    
67. ZHOU GF, Tang J, Ma YL, Fu X, et al
    ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
    Proc Natl Acad Sci U S A. 2023;120:e2220148120.
    PubMed     Abstract available
    
    
    
68. GHOSH S, Tugarinov V, Clore GM
    Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-beta42 aggregation and fibril formation.
    Proc Natl Acad Sci U S A. 2023;120:e2305823120.
    PubMed     Abstract available
    
    
    
69. MILLER A, Wei J, Meehan S, Dobson CM, et al
    Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
    Proc Natl Acad Sci U S A. 2023;120:e2216234120.
    PubMed     Abstract available
    
    
    
70. CHEN W, Huang Q, Lazdon EK, Gomes A, et al
    Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2220684120.
    PubMed     Abstract available
    
    
    
71. YANG XK, Zhang FL, Jin XK, Jiao YT, et al
    Nanoelectrochemistry reveals how soluble Abeta(42) oligomers alter vesicular storage and release of glutamate.
    Proc Natl Acad Sci U S A. 2023;120:e2219994120.
    PubMed     Abstract available
    
    
    
72. HASSANI SA, Neumann A, Russell J, Jones CK, et al
    M(1)-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.
    Proc Natl Acad Sci U S A. 2023;120:e2216792120.
    PubMed     Abstract available
    
    
    March 2023
73. CONDELLO C, Ayers JI, Dalgard CL, Garcia Garcia MM, et al
    Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Abeta prions.
    Proc Natl Acad Sci U S A. 2023;120:e2220984120.
    PubMed     Abstract available
    
    
    
74. YANG H, Yuan P, Wu Y, Shi M, et al
    EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
    Proc Natl Acad Sci U S A. 2023;120:e2300769120.
    PubMed     Abstract available
    
    
    
75. LEE M, Yau WM, Louis JM, Tycko R, et al
    Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions.
    Proc Natl Acad Sci U S A. 2023;120:e2218831120.
    PubMed     Abstract available
    
    

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