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  Asthma

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Articles published in Am J Respir Cell Mol Biol

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Single Articles


    February 2025
  1. OGAWA T, Maki Y, Takahashi S, Ono T, et al
    Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation.
    Am J Respir Cell Mol Biol. 2025;72:145-157.
    PubMed     Abstract available


    January 2025
  2. EL-HUSSEINI ZW, Karp T, Lan A, Gillett TE, et al
    Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression-Quantitative Trait Loci.
    Am J Respir Cell Mol Biol. 2025 Jan 21. doi: 10.1165/rcmb.2024-0251.
    PubMed     Abstract available


    December 2024
  3. LEE I, Ganesan A, Kalesinskas L, Zheng H, et al
    Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters.
    Am J Respir Cell Mol Biol. 2024 Dec 19. doi: 10.1165/rcmb.2024-0125.
    PubMed     Abstract available


  4. PINCUS AB, Pierce AB, Kappel N, Lebold KM, et al
    Parasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models.
    Am J Respir Cell Mol Biol. 2024 Dec 3. doi: 10.1165/rcmb.2024-0360.
    PubMed     Abstract available


  5. CHOUDHARY I, Lamichhane R, Singamsetty D, Vo T, et al
    Cell-Specific Contribution of IL-4 Receptor alpha Signaling Shapes the Overall Manifestation of Allergic Airway Disease.
    Am J Respir Cell Mol Biol. 2024;71:702-717.
    PubMed     Abstract available


    November 2024
  6. JANNU AK, Penn RB
    Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma.
    Am J Respir Cell Mol Biol. 2024 Nov 26. doi: 10.1165/rcmb.2024-0521.
    PubMed    


  7. CORTESELLI E, Alexis N
    Cough Variant Asthma: The Asthma Phenotype No One Coughs About.
    Am J Respir Cell Mol Biol. 2024 Nov 20. doi: 10.1165/rcmb.2024-0517.
    PubMed    


  8. WU A, Kuforiji A, Zhang Y, Xu D, et al
    TMEM16A Antagonism: Therapeutic Potential with Desensitization of beta-agonist Responsiveness in Asthma.
    Am J Respir Cell Mol Biol. 2024 Nov 19. doi: 10.1165/rcmb.2024-0231.
    PubMed     Abstract available


    October 2024
  9. CHEN Z, Jin K, Fang Z, Huang K, et al
    Sputum Metabolomic Signature and Dynamic Change of Cough Variant Asthma.
    Am J Respir Cell Mol Biol. 2024 Oct 11. doi: 10.1165/rcmb.2024-0219.
    PubMed     Abstract available


  10. WANG R, Liao G, Tang DD
    TET1 Regulates Nestin Expression and Human Airway Smooth Muscle Proliferation.
    Am J Respir Cell Mol Biol. 2024;71:420-429.
    PubMed     Abstract available


    September 2024
  11. CURTISS ML, Rothman PB
    Piecing Together the Role of IL-4 Receptor Alpha in Allergic Asthma One Cell at a Time.
    Am J Respir Cell Mol Biol. 2024 Sep 18. doi: 10.1165/rcmb.2024-0309.
    PubMed    


    August 2024
  12. GERBER AN
    Airway Smooth Muscle Dysfunction in Asthma: Releasing the Anchor.
    Am J Respir Cell Mol Biol. 2024 Aug 22. doi: 10.1165/rcmb.2024-0374.
    PubMed    


  13. PARK JA
    E-cad! That's a Big Switch from Epithelial Membrane Protein to Asthma Mediator.
    Am J Respir Cell Mol Biol. 2024 Aug 1. doi: 10.1165/rcmb.2024-0310.
    PubMed    


  14. WU D, Zhang X, Zimmerly KM, Wang R, et al
    Unconventional Activation of IRE1 Enhances Th17 Responses and Promotes Airway Neutrophilia.
    Am J Respir Cell Mol Biol. 2024;71:169-181.
    PubMed     Abstract available


    July 2024
  15. TANG H, Chen Z, Gan S, Guo Y, et al
    Soluble E-Cadherin Contributes to Airway Inflammation in Severe Asthma.
    Am J Respir Cell Mol Biol. 2024 Jul 30. doi: 10.1165/rcmb.2024-0133.
    PubMed     Abstract available


  16. KLEIN M, Gagnon PA, Salem M, Rouabhia M, et al
    MiR-155-5p Differentially Regulates IL-13Ralpha1 and IL-13Ralpha2 Expression and Signalling, Driving Abnormal Lung Epithelial Cell Phenotype in Severe Asthma.
    Am J Respir Cell Mol Biol. 2024 Jul 25. doi: 10.1165/rcmb.2024-0089.
    PubMed     Abstract available


    June 2024
  17. LEGRAND C, Vanneste D, Hego A, Sabatel C, et al
    Lung Interstitial Macrophages Can Present Soluble Antigens and Induce Foxp3(+) Regulatory T Cells.
    Am J Respir Cell Mol Biol. 2024;70:446-456.
    PubMed     Abstract available


    May 2024
  18. SEOW CY
    SRF Overexpression, A Double Trouble that May Underlie Airway Hyperresponsiveness in Asthma.
    Am J Respir Cell Mol Biol. 2024 May 2. doi: 10.1165/rcmb.2024-0168.
    PubMed    


  19. DONOVAN C, Thorpe AE, Gomez HM, Carroll OR, et al
    The GPR84 Antagonist GLPG1205 Reduces Features of Disease in Experimental Severe Asthma.
    Am J Respir Cell Mol Biol. 2024;70:424-427.
    PubMed    


    April 2024
  20. SHARMA S, Gerber AN, Kraft M, Wenzel SE, et al
    Asthma Pathogenesis: Phenotypes, Therapies and Gaps. Summary of the Aspen Lung Conference 2023.
    Am J Respir Cell Mol Biol. 2024 Apr 18. doi: 10.1165/rcmb.2024-0082.
    PubMed     Abstract available


  21. HICKMAN E, Alexis NE, Rager JE, Jaspers I, et al
    Airway Proteotypes of E-Cigarette Users Overlap with Those Found in Asthmatics.
    Am J Respir Cell Mol Biol. 2024;70:326-328.
    PubMed    


    December 2023
  22. VAGHASIYA J, Dalvand A, Sikarwar A, Mangat D, et al
    Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor-dependent Airway Smooth Muscle Contraction.
    Am J Respir Cell Mol Biol. 2023;69:649-665.
    PubMed     Abstract available


    August 2023
  23. DIAO J, Lam M, Gregory KJ, Leach K, et al
    Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
    Am J Respir Cell Mol Biol. 2023;69:182-196.
    PubMed     Abstract available


    June 2023
  24. ZHAO J, Zhang Q, Yao D, Wang T, et al
    Prenatal LPS Exposure Promotes Allergic Airway Inflammation via Long Coding RNA NONMMUT033452.2, and Protein Binding Partner, Eef1D.
    Am J Respir Cell Mol Biol. 2023;68:610-624.
    PubMed     Abstract available


    April 2023
  25. WU YC, Moon HG, Bindokas VP, Phillips EH, et al
    Multi-Resolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung.
    Am J Respir Cell Mol Biol. 2023 Apr 5. doi: 10.1165/rcmb.2022-0353.
    PubMed     Abstract available


  26. ZEIN JG, Bazeley P, Meyers D, Bleecker E, et al
    A Between-Sex Comparison of the Genomic Architecture of Asthma.
    Am J Respir Cell Mol Biol. 2023;68:456-458.
    PubMed    


  27. WOO JA, Castano M, Kee TR, Lee J, et al
    A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14.
    Am J Respir Cell Mol Biol. 2023;68:417-429.
    PubMed     Abstract available


    March 2023
  28. SHI N, Zhang J, Chen SY
    DOCK2 Promotes Asthma Development by Eliciting Airway Epithelial-Mesenchymal Transition.
    Am J Respir Cell Mol Biol. 2023 Mar 8. doi: 10.1165/rcmb.2022-0273.
    PubMed     Abstract available


  29. ZHAO L, Luo JL, Ali MK, Spiekerkoetter E, et al
    The Human Respiratory Microbiome: Current Understandings and Future Directions.
    Am J Respir Cell Mol Biol. 2023;68:245-255.
    PubMed     Abstract available


    February 2023
  30. LINDEN DA, Einarsson GG
    Early-Life Dysbiosis and Th17 Asthma: Never Is Better than Late.
    Am J Respir Cell Mol Biol. 2023 Feb 16. doi: 10.1165/rcmb.2023-0023.
    PubMed    


  31. JARAMILLO AM, Harder AQ, Holguin F, Evans CM, et al
    Vagal Reflexes in Airway Hyperreactivity: Novel Pathways and a Note of Caution for Studies in Mice.
    Am J Respir Cell Mol Biol. 2023;68:231-233.
    PubMed    


  32. NAKANO H, Cook DN
    CD109 Pumps Up Type Two Dendritic Cells for Allergic Responses in the Airways.
    Am J Respir Cell Mol Biol. 2023;68:127-128.
    PubMed    


  33. AONO Y, Suzuki Y, Horiguchi R, Inoue Y, et al
    CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation.
    Am J Respir Cell Mol Biol. 2023;68:201-212.
    PubMed     Abstract available


    January 2023
  34. KOBAYASHI T, Yasuma T, Gabazza EC
    Inflammation during Pregnancy Predisposes to Childhood Asthma by Altering Long Noncoding RNA Expression.
    Am J Respir Cell Mol Biol. 2023 Jan 26. doi: 10.1165/rcmb.2023-0004.
    PubMed    


  35. WILBURN AN, McAlees JW, Haslam DB, Graspeuntner S, et al
    Delayed Microbial Maturation Durably Exacerbates Th17 Driven Asthma in Mice.
    Am J Respir Cell Mol Biol. 2023 Jan 9. doi: 10.1165/rcmb.2022-0367.
    PubMed     Abstract available


  36. XU S, Karmacharya N, Woo J, Cao G, et al
    Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation-Contraction Coupling.
    Am J Respir Cell Mol Biol. 2023;68:39-48.
    PubMed     Abstract available


  37. HAO Y, Garcia-de-Alba-Rivas C
    Selective Inhibition of Extracellular Signal-regulated Kinases 1 and 2: When Less Is More.
    Am J Respir Cell Mol Biol. 2023;68:1-2.
    PubMed    


    November 2022
  38. PEDERSON WP, Ellerman LM, Sandoval EC, Boitano S, et al
    Development of a Novel Mouse Model of Menopause-associated Asthma.
    Am J Respir Cell Mol Biol. 2022;67:605-609.
    PubMed    


    October 2022
  39. TAN NS, Mukherjee M, Lim SY, Rouers A, et al
    A Unique CD27(-)IgD(-) B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity.
    Am J Respir Cell Mol Biol. 2022;67:506-511.
    PubMed    


  40. PEREZ-ZOGHBI JF, Sajorda DR, Webb DA, Arnold LA, et al
    Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.
    Am J Respir Cell Mol Biol. 2022;67:482-490.
    PubMed     Abstract available


  41. ASOSINGH K, Frimel M, Zlojutro V, Grant D, et al
    Preclinical Four-Dimensional Functional Lung Imaging and Quantification of Regional Airflow: A New Standard in Lung Function Evaluation in Murine Models.
    Am J Respir Cell Mol Biol. 2022;67:423-429.
    PubMed     Abstract available


    September 2022
  42. SHAH SD, Nayak AP, Sharma P, Villalba DR, et al
    Targeted Inhibition of Select ERK1/2 Functions Mitigates Pathological Features of Asthma in Mice.
    Am J Respir Cell Mol Biol. 2022 Sep 6. doi: 10.1165/rcmb.2022-0110.
    PubMed     Abstract available


    August 2022
  43. FENG Y, Chen S, Xiong L, Chang C, et al
    Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.
    Am J Respir Cell Mol Biol. 2022 Aug 5. doi: 10.1165/rcmb.2021-0109.
    PubMed     Abstract available


  44. KOZIK AJ, Holguin F, Segal LN, Chatila TA, et al
    Microbiome, Metabolism, and Immunoregulation of Asthma: An American Thoracic Society and National Institute of Allergy and Infectious Diseases Workshop Report.
    Am J Respir Cell Mol Biol. 2022;67:155-163.
    PubMed     Abstract available


    July 2022
  45. NAYAK AP, An SS
    Anxiolytics for Bronchodilation: Refinements to GABAA Agonists for Asthma Relief.
    Am J Respir Cell Mol Biol. 2022 Jul 28. doi: 10.1165/rcmb.2022-0287.
    PubMed    


  46. DO-UMEHARA HC, Chen C, Zhang Q, Schleimer RP, et al
    Suppression of Allergic Asthma by Loss of Function of Miz1-Mediated Th1 Skewing.
    Am J Respir Cell Mol Biol. 2022 Jul 14. doi: 10.1165/rcmb.2022-0135.
    PubMed     Abstract available


  47. WONG JTH, Elliot JG, Wang KCW, James AL, et al
    Does "Skippy" Wheeze? Evidence of Airway Remodeling in the Australian Kangaroo.
    Am J Respir Cell Mol Biol. 2022;67:125-127.
    PubMed    


    June 2022
  48. CURTISS ML, Deshane JS
    "Stick a Fork in Me; I'm Done": Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death.
    Am J Respir Cell Mol Biol. 2022;66:593-595.
    PubMed    


  49. GOUNNI AS, Koussih L
    SUMO Wrestling in the Airway Epithelium: Does It Regulate Thymic Stromal Lymphopoietin?
    Am J Respir Cell Mol Biol. 2022;66:591-592.
    PubMed    


    May 2022
  50. SCHOETTLER N, Dissanayake E, Craven MW, Yee JS, et al
    New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
    Am J Respir Cell Mol Biol. 2022 May 17. doi: 10.1165/rcmb.2022-0043.
    PubMed     Abstract available


    April 2022
  51. LEWIS BW, Britt RD Jr
    Maternal Allergen Exposures and Development of Asthma: Kids are Airways Nervy.
    Am J Respir Cell Mol Biol. 2022 Apr 21. doi: 10.1165/rcmb.2022-0101.
    PubMed    


  52. LEBOLD KM, Drake MG, Pincus AB, Pierce AB, et al
    Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite Exposed Mice.
    Am J Respir Cell Mol Biol. 2022 Apr 1. doi: 10.1165/rcmb.2021-0535.
    PubMed     Abstract available


  53. PEEBLES RS JR
    IL-13 Protects against SARS-CoV-2?
    Am J Respir Cell Mol Biol. 2022;66:351-352.
    PubMed    


    March 2022
  54. LIANG S, Zhou Z, Yu C, Zhou Z, et al
    CBX4 Regulates Long-Form Thymic Stromal Lymphopoietin-Mediated Airway Inflammation Through SUMOylation in HDM-Induced Asthma.
    Am J Respir Cell Mol Biol. 2022 Mar 31. doi: 10.1165/rcmb.2021-0301.
    PubMed     Abstract available


  55. GUO F, Hao Y, Zhang L, Croteau-Chonka DC, et al
    The Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium.
    Am J Respir Cell Mol Biol. 2022 Mar 30. doi: 10.1165/rcmb.2021-0305.
    PubMed     Abstract available


  56. ZHAO MZ, Liu HZ, Geng XR, Liu ZG, et al
    Identification of a Fraction of Cross-Reactive Th2 Cells in Patients with Allergic Asthma.
    Am J Respir Cell Mol Biol. 2022;66:343-346.
    PubMed    


  57. WU X, Johnson JR
    Drivers of Type 2 Inflammation in Allergic Airway Disease: Wnt You Like to Know?
    Am J Respir Cell Mol Biol. 2022;66:245-247.
    PubMed    


    February 2022
  58. LIAO G, Wang R, Tang DD
    Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells.
    Am J Respir Cell Mol Biol. 2022;66:223-234.
    PubMed     Abstract available


    January 2022
  59. PANGANIBAN RA, Lu Q
    A Long Non-Coding RNA "lnc"ed to Asthma Genetics.
    Am J Respir Cell Mol Biol. 2022 Jan 14. doi: 10.1165/rcmb.2021-0534.
    PubMed    


  60. BONSER LR, Eckalbar WL, Rodriguez L, Shen J, et al
    The Type 2 Asthma Mediator IL-13 Inhibits SARS-CoV-2 Infection of Bronchial Epithelium.
    Am J Respir Cell Mol Biol. 2022 Jan 4. doi: 10.1165/rcmb.2021-0364.
    PubMed     Abstract available


  61. CAO G, Lam H, Jude JA, Karmacharya N, et al
    Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation.
    Am J Respir Cell Mol Biol. 2022;66:96-106.
    PubMed     Abstract available


    December 2021
  62. RAI N, Arteaga-Solis E, Goldklang M, Zelonina T, et al
    The Role of Secreted Frizzled Related Protein-1 in Allergic Asthma.
    Am J Respir Cell Mol Biol. 2021 Dec 20. doi: 10.1165/rcmb.2020-0314.
    PubMed     Abstract available


  63. VLAHOS R
    SPLUNC1 alpha6 Peptidomimetic: A Novel Therapeutic for Asthma.
    Am J Respir Cell Mol Biol. 2021 Dec 14. doi: 10.1165/rcmb.2021-0451.
    PubMed    


  64. LI YK, Zhang XX, Yang Y, Gao J, et al
    Convergent Evidence Supports TH2LCRR as a Novel Asthma Susceptibility Gene.
    Am J Respir Cell Mol Biol. 2021 Dec 1. doi: 10.1165/rcmb.2020-0481.
    PubMed     Abstract available


  65. SMITH GJ, Tovar A, McFadden K, Moran TP, et al
    A Murine Model of Ozone-induced Nonatopic Asthma from the Collaborative Cross.
    Am J Respir Cell Mol Biol. 2021;65:672-674.
    PubMed    


    November 2021
  66. WRENNALL JA, Ahmad S, Worthington EN, Wu T, et al
    A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model.
    Am J Respir Cell Mol Biol. 2021 Nov 22. doi: 10.1165/rcmb.2020-0452.
    PubMed     Abstract available


  67. TAM JKC, Tran T
    Plk1 in Asthma - Ready for Primetime?
    Am J Respir Cell Mol Biol. 2021 Nov 8. doi: 10.1165/rcmb.2021-0425.
    PubMed    


    May 2021
  68. REDDY KD, Lan A, Boudewijn IM, Rathnayake SNH, et al
    Current-Smoking alters Gene Expression and DNA Methylation in the Nasal Epithelium of Asthmatics.
    Am J Respir Cell Mol Biol. 2021 May 14. doi: 10.1165/rcmb.2020-0553.
    PubMed     Abstract available


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