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Autoimmune Disorders

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 74 articles: HTML format

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February 2026
1. CUI T, Wen Q, An Z, Kang J, et al
   Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1-astrocytic integrin alpha4 interaction.
   Proc Natl Acad Sci U S A. 2026;123:e2520566123.
   PubMed     Abstract available
   
   
   
2. LIAN L, Jang B, Huayamares SG, Shakked A, et al
   Lipid nanoparticle GM-CSF replacement for autoimmune pulmonary alveolar proteinosis.
   Proc Natl Acad Sci U S A. 2026;123:e2511483123.
   PubMed     Abstract available
   
   
   
3. SONG Y, Huang X, Wei L, Shen W, et al
   TRIM21enhances IL-17A signaling and drives autoimmune myocarditis by promoting TRAF3 lysosomaldegradation in cardiac fibroblasts.
   Proc Natl Acad Sci U S A. 2026;123:e2426265123.
   PubMed     Abstract available
   
   
   
4. OLCHANYI MD, Schreier DR, Li J, Maffei C, et al
   Probabilistic mapping and automated segmentation of human brainstem white matter bundles.
   Proc Natl Acad Sci U S A. 2026;123:e2509321123.
   PubMed     Abstract available
   
   
   
5. 
   Correction for Curtis et al., Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases.
   Proc Natl Acad Sci U S A. 2026;123:e2538063123.
   PubMed    
   
   
   January 2026
6. GERVAIS A, Bastard P, Zhang Q, Jaffar-Bandjee MC, et al
   Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis.
   Proc Natl Acad Sci U S A. 2026;123:e2532212123.
   PubMed     Abstract available
   
   
   
7. KOMIYAMA S, Kodaira Y, Maeda R, Sugiura Y, et al
   M cell-dependent commensal uptake confers encephalitogenic phenotypes on gammadeltaT17 cells in Peyer's patches.
   Proc Natl Acad Sci U S A. 2026;123:e2506550123.
   PubMed     Abstract available
   
   
   
8. GUAN Y, Yu Y, Fu M, Xu H, et al
   Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes.
   Proc Natl Acad Sci U S A. 2026;123:e2503783123.
   PubMed     Abstract available
   
   
   December 2025
9. FRATUS M, Alam MA
   A closed-loop microneedle-integrated physiological model for predictive glycemic management.
   Proc Natl Acad Sci U S A. 2025;122:e2523517122.
   PubMed     Abstract available
   
   
   
10. TAGHIPOUR-MIRAKMAHALEH R, Morin F, Zhang Y, Bourhoven L, et al
    Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2424988122.
    PubMed     Abstract available
    
    
    
11. JIA L, Liu M, Ji H, Lei J, et al
    Glomerular endothelial cells eliminate nicotinamide adenine dinucleotide to instruct CD103(+) T cells in human lupus nephritis.
    Proc Natl Acad Sci U S A. 2025;122:e2507422122.
    PubMed     Abstract available
    
    
    November 2025
12. KAPNICK SM, Gosselin EA, Tsai SJ, Oakes RS, et al
    Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity.
    Proc Natl Acad Sci U S A. 2025;122:e2409563122.
    PubMed     Abstract available
    
    
    October 2025
13. BAYER AC, Sanmarco LM, Pellerin A, Masi G, et al
    Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology.
    Proc Natl Acad Sci U S A. 2025;122:e2505984122.
    PubMed     Abstract available
    
    
    
14. TRSELIC T, Pelo N, Martin de Fremont G, Iyer VS, et al
    Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility.
    Proc Natl Acad Sci U S A. 2025;122:e2426917122.
    PubMed     Abstract available
    
    
    
15. 
    Correction for Zhao et al., Blood-labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus.
    Proc Natl Acad Sci U S A. 2025;122:e2525323122.
    PubMed    
    
    
    September 2025
16. MYKICKI N, Eble JA, Weighardt H, Gonnelli E, et al
    AhR signaling in skin-resident CD207(+) cells is involved in UV-B-induced amelioration of neuroinflammation.
    Proc Natl Acad Sci U S A. 2025;122:e2424009122.
    PubMed     Abstract available
    
    
    August 2025
17. CURTIS SD, Liu T, Bai Y, Wang Y, et al
    Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases.
    Proc Natl Acad Sci U S A. 2025;122:e2426890122.
    PubMed     Abstract available
    
    
    
18. ZHAO Z, Li A, Zhu Y, Cen S, et al
    Blood-labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus.
    Proc Natl Acad Sci U S A. 2025;122:e2423240122.
    PubMed     Abstract available
    
    
    
19. NEMATULLAH M, Fatma M, Zhou G, Prajapati B, et al
    Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity.
    Proc Natl Acad Sci U S A. 2025;122:e2427052122.
    PubMed     Abstract available
    
    
    July 2025
20. SIMKA M
    Previous epidemiological studies support the idea of ileal microbiota triggering multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2514491122.
    PubMed    
    
    
    
21. JIANG Y, Liu Q, Stridh P, Kockum I, et al
    Multiomics integration prioritizes potential drug targets for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2425537122.
    PubMed     Abstract available
    
    
    June 2025
22. ATKINSON KC, Desfor S, Feri M, Sekyi MT, et al
    Decreased mitochondrial activity in the demyelinating cerebellum of progressive multiple sclerosis and chronic EAE contributes to Purkinje cell loss.
    Proc Natl Acad Sci U S A. 2025;122:e2421806122.
    PubMed     Abstract available
    
    
    
23. 
    Editorial Expression of Concern for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2512750122.
    PubMed    
    
    
    May 2025
24. JENSEN LT, Fugger L
    Immune perturbation by the ileal microbiota in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2506777122.
    PubMed    
    
    
    
25. GUPTA S, Arnab S, Nguyen KL, Reed M, et al
    Sex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2 activation in a model of MS and CNP.
    Proc Natl Acad Sci U S A. 2025;122:e2426771122.
    PubMed     Abstract available
    
    
    
26. YOON H, Gerdes LA, Beigel F, Sun Y, et al
    Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.
    Proc Natl Acad Sci U S A. 2025;122:e2419689122.
    PubMed     Abstract available
    
    
    April 2025
27. MECHELLI R, Umeton R, Bellucci G, Bigi R, et al
    A disease-specific convergence of host and Epstein-Barr virus genetics in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2418783122.
    PubMed     Abstract available
    
    
    
28. HOU J, Magliozzi R, Chen Y, Wu J, et al
    Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination.
    Proc Natl Acad Sci U S A. 2025;122:e2426786122.
    PubMed     Abstract available
    
    
    
29. MOLITOR TP, Hayashi G, Lin MY, Dunn CJ, et al
    Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator.
    Proc Natl Acad Sci U S A. 2025;122:e2422172122.
    PubMed     Abstract available
    
    
    March 2025
30. ORR N, Steinman L
    Epstein-Barr virus and the immune microenvironment in multiple sclerosis: Insights from high-dimensional brain tissue imaging.
    Proc Natl Acad Sci U S A. 2025;122:e2425670122.
    PubMed     Abstract available
    
    
    
31. SATTARNEZHAD N, Kockum I, Thomas OG, Liu Y, et al
    Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls.
    Proc Natl Acad Sci U S A. 2025;122:e2424986122.
    PubMed     Abstract available
    
    
    
32. GHIMIRE S, Lehman PC, Aguilar Meza LS, Shahi SK, et al
    Specific microbial ratio in the gut microbiome is associated with multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2413953122.
    PubMed     Abstract available
    
    
    February 2025
33. RAD LM, Hughes KR, Wheeler SN, Decker JT, et al
    Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis.
    Proc Natl Acad Sci U S A. 2025;122:e2409852122.
    PubMed     Abstract available
    
    
    
34. 
    Correction for Cao et al., Circadian clock cryptochrome proteins regulate autoimmunity.
    Proc Natl Acad Sci U S A. 2025;122:e2425633121.
    PubMed    
    
    
    December 2024
35. LANZ TV, Robinson WH
    Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles connects the two main risk factors of multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2420070121.
    PubMed    
    
    
    November 2024
36. OKAMOTO M, Kuratani A, Okuzaki D, Kamiyama N, et al
    IFN-gamma-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.
    Proc Natl Acad Sci U S A. 2024;121:e2401692121.
    PubMed     Abstract available
    
    
    
37. MOURAD NI, Perota A, Xhema D, Duchi R, et al
    Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy.
    Proc Natl Acad Sci U S A. 2024;121:e2409138121.
    PubMed     Abstract available
    
    
    October 2024
38. DROSU N, Anderson M, Bilodeau PA, Nishiyama S, et al
    CD4 T cells restricted to DRB1*15:01 recognize two Epstein-Barr virus glycoproteins capable of intracellular antigen presentation.
    Proc Natl Acad Sci U S A. 2024;121:e2416097121.
    PubMed     Abstract available
    
    
    
39. 
    Correction for Poon et al., Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2420080121.
    PubMed    
    
    
    September 2024
40. LI W, He S, Tan J, Li N, et al
    Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
    Proc Natl Acad Sci U S A. 2024;121:e2316161121.
    PubMed     Abstract available
    
    
    
41. OURY J, Gamallo-Lana B, Santana L, Steyaert C, et al
    Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.
    Proc Natl Acad Sci U S A. 2024;121:e2408324121.
    PubMed     Abstract available
    
    
    
42. LI T, Yum S, Wu J, Li M, et al
    cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice.
    Proc Natl Acad Sci U S A. 2024;121:e2411747121.
    PubMed     Abstract available
    
    
    August 2024
43. DENEEN B
    Pipe dream: Remyelination therapy for multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2414324121.
    PubMed    
    
    
    
44. ALAKHRAS NS, Zhang W, Barros N, Sharma A, et al
    An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation.
    Proc Natl Acad Sci U S A. 2024;121:e2400153121.
    PubMed     Abstract available
    
    
    
45. POON MM, Lorrain KI, Stebbins KJ, Edu GC, et al
    Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407974121.
    PubMed     Abstract available
    
    
    July 2024
46. NATARAJAN C, Le LHD, Gunasekaran M, Tracey KJ, et al
    Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis.
    Proc Natl Acad Sci U S A. 2024;121:e2322577121.
    PubMed     Abstract available
    
    
    June 2024
47. FAISSNER S, Motte J, Sgodzai M, Geis C, et al
    Successful use of anti-CD19 CAR T cells in severe treatment-refractory stiff-person syndrome.
    Proc Natl Acad Sci U S A. 2024;121:e2403227121.
    PubMed     Abstract available
    
    
    
48. PARK J, Lee J, Hur Y, Kim CJ, et al
    ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
    Proc Natl Acad Sci U S A. 2024;121:e2322009121.
    PubMed     Abstract available
    
    
    
49. RAKEBRANDT N, Yassini N, Kolz A, Schorer M, et al
    Innate acting memory Th1 cells modulate heterologous diseases.
    Proc Natl Acad Sci U S A. 2024;121:e2312837121.
    PubMed     Abstract available
    
    
    
50. SULADZE S, Sarkar R, Rodina N, Bokvist K, et al
    Atomic resolution structure of full-length human insulin fibrils.
    Proc Natl Acad Sci U S A. 2024;121:e2401458121.
    PubMed     Abstract available
    
    
    May 2024
51. 
    Correction for Ichimura et al., Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2408646121.
    PubMed    
    
    
    April 2024
52. COSTANZA M, Ciotti A, Consonni A, Cipelletti B, et al
    CNS autoimmune response in the MAM/pilocarpine rat model of epileptogenic cortical malformation.
    Proc Natl Acad Sci U S A. 2024;121:e2319607121.
    PubMed     Abstract available
    
    
    
53. THOMAS MA, Naik P, Wang H, Giles JT, et al
    The monocyte cell surface is a unique site of autoantigen generation in rheumatoid arthritis.
    Proc Natl Acad Sci U S A. 2024;121:e2304199121.
    PubMed     Abstract available
    
    
    
54. ICHIMURA Y, Konishi R, Shobo M, Tanaka R, et al
    Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2313070121.
    PubMed     Abstract available
    
    
    March 2024
55. VENEGAS-SOLIS F, Staliunaite L, Rudolph E, Munch CC, et al
    A type I interferon regulatory network for human plasmacytoid dendritic cells based on heparin, membrane-bound and soluble BDCA-2.
    Proc Natl Acad Sci U S A. 2024;121:e2312404121.
    PubMed     Abstract available
    
    
    
56. YIN R, Melton S, Huseby ES, Kardar M, et al
    How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease.
    Proc Natl Acad Sci U S A. 2024;121:e2318599121.
    PubMed     Abstract available
    
    
    
57. ANEES F, Montoya DA, Pisetsky DS, Payne CK, et al
    DNA corona on nanoparticles leads to an enhanced immunostimulatory effect with implications for autoimmune diseases.
    Proc Natl Acad Sci U S A. 2024;121:e2319634121.
    PubMed     Abstract available
    
    
    February 2024
58. IVERSEN R, Sollid LM
    Dissecting autoimmune encephalitis through the lens of intrathecal B cells.
    Proc Natl Acad Sci U S A. 2024;121:e2401337121.
    PubMed    
    
    
    
59. ADAMS C, Manouchehrinia A, Quach HL, Quach DL, et al
    Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans.
    Proc Natl Acad Sci U S A. 2024;121:e2302259121.
    PubMed     Abstract available
    
    
    
60. CHEN Y, Chen K, Zhu H, Qin H, et al
    Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling.
    Proc Natl Acad Sci U S A. 2024;121:e2314561121.
    PubMed     Abstract available
    
    
    
61. THEORELL J, Harrison R, Williams R, Raybould MIJ, et al
    Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis.
    Proc Natl Acad Sci U S A. 2024;121:e2311049121.
    PubMed     Abstract available
    
    
    
62. QIN C, Dong MH, Zhou LQ, Wang W, et al
    Single-cell analysis of refractory anti-SRP necrotizing myopathy treated with anti-BCMA CAR-T cell therapy.
    Proc Natl Acad Sci U S A. 2024;121:e2315990121.
    PubMed     Abstract available
    
    
    
63. SELCK C, Jhala G, De George DJ, Kwong CJ, et al
    Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes.
    Proc Natl Acad Sci U S A. 2024;121:e2315419121.
    PubMed     Abstract available
    
    
    January 2024
64. SUTTER PA, Willis CM, Menoret A, Nicaise AM, et al
    Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses.
    Proc Natl Acad Sci U S A. 2024;121:e2306816121.
    PubMed     Abstract available
    
    
    
65. AHMED AR, Kalesinskas M, Kaveri SV
    Restoring immune tolerance in pemphigus vulgaris.
    Proc Natl Acad Sci U S A. 2024;121:e2317762121.
    PubMed     Abstract available
    
    
    
66. GOTTLIEB A, Pham HPT, Saltarrelli JG, Lindsey JW, et al
    Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells.
    Proc Natl Acad Sci U S A. 2024;121:e2315857121.
    PubMed     Abstract available
    
    
    December 2023
67. DIJKSTRA DJ, van de Bovenkamp FS, Abendstein L, Zuijderduijn R, et al
    Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
    Proc Natl Acad Sci U S A. 2023;120:e2310666120.
    PubMed     Abstract available
    
    
    
68. YE C, Clements SA, Gu W, Geurts AM, et al
    Deletion of Vbeta3(+)CD4(+) T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8(+) T cells.
    Proc Natl Acad Sci U S A. 2023;120:e2312039120.
    PubMed     Abstract available
    
    
    
69. SHIMO Y, Cathomas F, Lin HY, Chan KL, et al
    Social stress induces autoimmune responses against the brain.
    Proc Natl Acad Sci U S A. 2023;120:e2305778120.
    PubMed     Abstract available
    
    
    November 2023
70. SCHMIDT H, Raj T, O'Neill TJ, Muschaweckh A, et al
    Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
    Proc Natl Acad Sci U S A. 2023;120:e2309205120.
    PubMed     Abstract available
    
    
    
71. THOMANN AS, McQuade CA, Pinjusic K, Kolz A, et al
    A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity.
    Proc Natl Acad Sci U S A. 2023;120:e2300733120.
    PubMed     Abstract available
    
    
    September 2023
72. GRUCHOT J, Lewen I, Dietrich M, Reiche L, et al
    Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.
    Proc Natl Acad Sci U S A. 2023;120:e2308187120.
    PubMed     Abstract available
    
    
    
73. GAN T, Wang D
    Picobirnaviruses encode proteins that are functional bacterial lysins.
    Proc Natl Acad Sci U S A. 2023;120:e2309647120.
    PubMed     Abstract available
    
    
    
74. GARCIA CORRALES AV, Verberk SGS, Haidar M, Grajchen E, et al
    Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination.
    Proc Natl Acad Sci U S A. 2023;120:e2301030120.
    PubMed     Abstract available
    
    

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