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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 73 articles:
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Single Articles


    November 2022
  1. RUBIN DE CELIS MF, Garcia-Martin R, Syed I, Lee J, et al
    PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.
    Proc Natl Acad Sci U S A. 2022;119:e2206923119.
    PubMed     Abstract available


  2. PENG V, Cao S, Trsan T, Bando JK, et al
    Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.
    Proc Natl Acad Sci U S A. 2022;119:e2214900119.
    PubMed     Abstract available


  3. LIAO Y, Fan L, Bin P, Zhu C, et al
    GABA signaling enforces intestinal germinal center B cell differentiation.
    Proc Natl Acad Sci U S A. 2022;119:e2215921119.
    PubMed     Abstract available


    October 2022
  4. KWIATKOWSKI AJ, Helm EY, Stewart JM, Drashansky TT, et al
    Treatment with an antigen-specific dual microparticle system reverses advanced multiple sclerosis in mice.
    Proc Natl Acad Sci U S A. 2022;119:e2205417119.
    PubMed     Abstract available


  5. BEHRANGI N, Heinig L, Frintrop L, Santrau E, et al
    Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5.
    Proc Natl Acad Sci U S A. 2022;119:e2204509119.
    PubMed     Abstract available


    September 2022
  6. ZHU Z, Chen X, Wang C, Cheng L, et al
    Novel genes/loci validate the small effect size of ERBB2 in patients with myasthenia gravis.
    Proc Natl Acad Sci U S A. 2022;119:e2207273119.
    PubMed    


  7. CHIA R, Saez-Atienzar S, Drachman DB, Traynor BJ, et al
    Reply to Zhu et al.: Implications of CHRNB1 and ERBB2 in the pathobiology of myasthenia gravis.
    Proc Natl Acad Sci U S A. 2022;119:e2209096119.
    PubMed    


    August 2022
  8. MEYER T, Shimon D, Youssef S, Yankovitz G, et al
    NAD(+) metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity.
    Proc Natl Acad Sci U S A. 2022;119:e2211310119.
    PubMed     Abstract available


  9. DIEBOLD M, Galli E, Kopf A, Sanderson NSR, et al
    High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2022;119:e2205042119.
    PubMed     Abstract available


  10. GIRDHAR K, Huang Q, Chow IT, Vatanen T, et al
    A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.
    Proc Natl Acad Sci U S A. 2022;119:e2120028119.
    PubMed     Abstract available


  11. XIA M, Zhang C, Chen Y, Zhao X, et al
    Transcription factor EB coordinates environmental cues to regulate T regulatory cells' mitochondrial fitness and function.
    Proc Natl Acad Sci U S A. 2022;119:e2205469119.
    PubMed     Abstract available


    July 2022
  12. FRESQUET M, Lockhart-Cairns MP, Rhoden SJ, Jowitt TA, et al
    Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch.
    Proc Natl Acad Sci U S A. 2022;119:e2202209119.
    PubMed     Abstract available


    June 2022
  13. ZAHOOR I, Suhail H, Datta I, Ahmed ME, et al
    Blood-based untargeted metabolomics in relapsing-remitting multiple sclerosis revealed the testable therapeutic target.
    Proc Natl Acad Sci U S A. 2022;119:e2123265119.
    PubMed     Abstract available


  14. KIM S, Lu HC, Steelman AJ, Li J, et al
    Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1beta production and CD4 T cell activation in autoimmune demyelination.
    Proc Natl Acad Sci U S A. 2022;119:e2117636119.
    PubMed     Abstract available


  15. DAMATO V, Theorell J, Al-Diwani A, Kienzler AK, et al
    Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders.
    Proc Natl Acad Sci U S A. 2022;119:e2121804119.
    PubMed     Abstract available



  16. Correction for Chia et al., Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.
    Proc Natl Acad Sci U S A. 2022;119:e2206754119.
    PubMed    


    May 2022
  17. MANRY J, Bastard P, Gervais A, Le Voyer T, et al
    The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
    Proc Natl Acad Sci U S A. 2022;119:e2200413119.
    PubMed     Abstract available


  18. KISSLER S
    Toward a precision medicine approach for autoimmunity.
    Proc Natl Acad Sci U S A. 2022;119:e2204841119.
    PubMed    


    April 2022
  19. YU L, He L, Gan B, Ti R, et al
    Structural insights into sphingosine-1-phosphate receptor activation.
    Proc Natl Acad Sci U S A. 2022;119:e2117716119.
    PubMed     Abstract available


  20. POLICHENI AN, Teh CE, Robbins A, Tuzlak S, et al
    PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease.
    Proc Natl Acad Sci U S A. 2022;119:e2120149119.
    PubMed     Abstract available


  21. POSTIGO-FERNANDEZ J, Firdessa-Fite R, Creusot RJ
    Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2022;119:e2110987119.
    PubMed     Abstract available


  22. HWANG D, Seyedsadr MS, Ishikawa LLW, Boehm A, et al
    CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.
    Proc Natl Acad Sci U S A. 2022;119:e2111804119.
    PubMed     Abstract available


    March 2022
  23. SARRAZIN N, Chavret-Reculon E, Bachelin C, Felfli M, et al
    Failed remyelination of the nonhuman primate optic nerve leads to axon degeneration, retinal damages, and visual dysfunction.
    Proc Natl Acad Sci U S A. 2022;119:e2115973119.
    PubMed     Abstract available


  24. GUPTA A, Smith P, Bournazos S, Ravetch JV, et al
    A novel mouse strain optimized for chronic human antibody administration.
    Proc Natl Acad Sci U S A. 2022;119:e2123002119.
    PubMed     Abstract available


  25. CHUNDER R, Weier A, Maurer H, Luber N, et al
    Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination.
    Proc Natl Acad Sci U S A. 2022;119:e2117034119.
    PubMed     Abstract available


    February 2022
  26. LIU D, Zhao Z, She Y, Zhang L, et al
    TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  27. AMENDT T, Allies G, Nicolo A, El Ayoubi O, et al
    Autoreactive antibodies control blood glucose by regulating insulin homeostasis.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  28. GUO X, Kimura A, Namekata K, Harada C, et al
    ASK1 signaling regulates phase-specific glial interactions during neuroinflammation.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  29. BUCALA RJ
    Targeting fibrocytes in autoimmunity.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed    


  30. CHIA R, Saez-Atienzar S, Murphy N, Chio A, et al
    Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    January 2022
  31. WANG Y, Guo L, Yin X, McCarthy EC, et al
    Pathogenic TNF-alpha drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    December 2021
  32. MONAGHAN KL, Aesoph D, Ammer AG, Zheng W, et al
    Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  33. FERNANDO R, Caldera O, Smith TJ
    Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  34. CHANDRAN V, Bermudez ML, Koka M, Chandran B, et al
    Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  35. MA Q, Caillier SJ, Muzic S, Wilson MR, et al
    Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  36. LANDEGREN N, Ishii N, Aranda-Guillen M, Gunnarsson HI, et al
    A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  37. VAN DER VAART J, Bosmans L, Sijbesma SF, Knoops K, et al
    Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  38. IRIKI H, Takahashi H, Wada N, Nomura H, et al
    Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    November 2021
  39. FORAY AP, Candon S, Hildebrand S, Marquet C, et al
    De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  40. CHOI JK, Yu CR, Bing SJ, Jittayasothorn Y, et al
    IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  41. VARATHARAJ A, Carare RO, Weller RO, Gawne-Cain M, et al
    Gadolinium enhancement of cranial nerves: Implications for interstitial fluid drainage from brainstem into cranial nerves in humans.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  42. VON HERRATH M, Bonifacio E
    How benign autoimmunity becomes detrimental in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  43. WANG J, Jalali Motlagh N, Wang C, Wojtkiewicz GR, et al
    d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021
  44. RAMIREZ DG, Ciccaglione M, Upadhyay AK, Pham VT, et al
    Detecting insulitis in type 1 diabetes with ultrasound phase-change contrast agents.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  45. ANDERSON AM, Landry LG, Alkanani AA, Pyle L, et al
    Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  46. MANOUCHEHRI N, Stuve O
    Choroid plexus volumetrics and brain inflammation in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    September 2021
  47. YANG K, O'Cearbhaill ED, Liu SS, Zhou A, et al
    A therapeutic convection-enhanced macroencapsulation device for enhancing beta cell viability and insulin secretion.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  48. FLEISCHER V, Gonzalez-Escamilla G, Ciolac D, Albrecht P, et al
    Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  49. HARTLEHNERT M, Borsch AL, Li X, Burmeister M, et al
    Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021
  50. LAROCHELLE C, Wasser B, Jamann H, Loffel JT, et al
    Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  51. SINGH KD, Jara ZP, Harford T, Saha PP, et al
    Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  52. LONGBRAKE EE, Hafler DA
    (23)Na imaging: Worth its salt for understanding multiple sclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  53. JING X, Yao Y, Wu D, Hong H, et al
    IFP35 family proteins promote neuroinflammation and multiple sclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    July 2021
  54. JUUL-MADSEN K, Troldborg A, Wittenborn TR, Axelsen MG, et al
    Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available



  55. Correction for Ostkamp et al., Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  56. BRYAN CM, Rocklin GJ, Bick MJ, Ford A, et al
    Computational design of a synthetic PD-1 agonist.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  57. HUHN K, Linz P, Pemsel F, Michalke B, et al
    Skin sodium is increased in male patients with multiple sclerosis and related animal models.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  58. COLOMBO E, Triolo D, Bassani C, Bedogni F, et al
    Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  59. PATERGNANI S, Bonora M, Ingusci S, Previati M, et al
    Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  60. PYFROM S, Paneru B, Knox JJ, Cancro MP, et al
    The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  61. HUANG YS, Tseng WY, Clanchy FIL, Topping LM, et al
    Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  62. UMEDA M, Yoshida N, Hisada R, Burbano C, et al
    ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-beta1.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  63. BARNES SE, Han MH
    CD317 puts the brakes on dendritic cell trafficking to the CNS.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    April 2021
  64. ZHELEZNYAKOVA GY, Piket E, Needhamsen M, Hagemann-Jensen M, et al
    Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available



  65. Correction to Supporting Information for Luo et al., The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    March 2021
  66. SUN T, Yu Y, Wu X, Acevedo A, et al
    Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  67. RAVENEY BJE, Sato W, Takewaki D, Zhang C, et al
    Involvement of cytotoxic Eomes-expressing CD4(+) T cells in secondary progressive multiple sclerosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  68. TOROK O, Schreiner B, Schaffenrath J, Tsai HC, et al
    Pericytes regulate vascular immune homeostasis in the CNS.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  69. WANG MY, Dean ED, Quittner-Strom E, Zhu Y, et al
    Glucagon blockade restores functional beta-cell mass in type 1 diabetic mice and enhances function of human islets.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    February 2021
  70. TEO W, Caprariello AV, Morgan ML, Luchicchi A, et al
    Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  71. MITCHELL AM, Alkanani AA, McDaniel KA, Pyle L, et al
    T-cell responses to hybrid insulin peptides prior to type 1 diabetes development.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  72. MUNOZ M, Hegazy AN, Brunner TM, Holecska V, et al
    Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  73. MARSLAND R 3RD, Howell O, Mayer A, Mehta P, et al
    Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


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