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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 39 articles:
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Single Articles


    July 2025
  1. HORWITZ E, Dubash TD, Szabolcs A, Wittner BS, et al
    CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.
    Proc Natl Acad Sci U S A. 2025;122:e2507203122.
    PubMed     Abstract available


  2. SUN R, Jiang P, Wang Z, Yan B, et al
    DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers.
    Proc Natl Acad Sci U S A. 2025;122:e2413732122.
    PubMed     Abstract available


  3. ZOU Y, Wang Z, Jiang Q, Kong X, et al
    UFMylation: A supervisor of the HIF1alpha pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors.
    Proc Natl Acad Sci U S A. 2025;122:e2500562122.
    PubMed     Abstract available


  4. GUO J, Li K, Ming Y, Pan Y, et al
    A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
    Proc Natl Acad Sci U S A. 2025;122:e2504320122.
    PubMed     Abstract available


  5. LIM J, Jung HD, Park SY, Jeon M, et al
    Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets.
    Proc Natl Acad Sci U S A. 2025;122:e2425384122.
    PubMed     Abstract available


    June 2025
  6. ZENG W, Guo H, Liu Q, Wong WH, et al
    Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features.
    Proc Natl Acad Sci U S A. 2025;122:e2419202122.
    PubMed     Abstract available


  7. OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al
    Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420174122.
    PubMed     Abstract available


  8. DING Q, Liu J, Wang Y, Kim J, et al
    Dual-laser "808 and 1,064 nm" strategy that circumvents the Achilles' heel of photothermal therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2503574122.
    PubMed     Abstract available


    May 2025
  9. FERRERO G, Cardamone MD, Luca F, Bourk E, et al
    Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2502805122.
    PubMed     Abstract available


    April 2025
  10. CHEN YF, Zhang QH, Zhang ZW, Zhou YJ, et al
    SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2417586122.
    PubMed     Abstract available


  11. ZHAO X, Zhao Y, Li Z, Liu H, et al
    Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization.
    Proc Natl Acad Sci U S A. 2025;122:e2425000122.
    PubMed     Abstract available


    March 2025

  12. Correction for Qin et al., A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2502214122.
    PubMed    


  13. STAROSTECKA M, Jeong H, Hasenfeld P, Benito-Garagorri E, et al
    Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model.
    Proc Natl Acad Sci U S A. 2025;122:e2415475122.
    PubMed     Abstract available


    February 2025
  14. YI J, Du J, Chen X, Nie RC, et al
    A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2420383122.
    PubMed     Abstract available


  15. LEI L, Song Y, Yang L, Wang Y, et al
    Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2416796122.
    PubMed     Abstract available


    January 2025
  16. QIN G, Shao X, Liu X, Xu J, et al
    A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2421710122.
    PubMed     Abstract available


  17. ZHENG M, Wang S, Tang K, Kong R, et al
    The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2413890121.
    PubMed     Abstract available


    December 2024
  18. GONZALEZ-FERNANDEZ M, Perry C, Gerhards NM, Francica P, et al
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1.
    Proc Natl Acad Sci U S A. 2024;121:e2402849121.
    PubMed     Abstract available


  19. SINHA A, Saini KK, Chandramouli A, Tripathi K, et al
    ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis.
    Proc Natl Acad Sci U S A. 2024;121:e2408049121.
    PubMed     Abstract available


  20. MATSUZAKI T, Fujii M, Noro H, Togo S, et al
    Simultaneous visualization of membrane fluidity and morphology defines adhesion signatures of cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2412914121.
    PubMed     Abstract available


    November 2024
  21. DING X, Liang J, Sharko AC, Hilimire TA, et al
    Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors.
    Proc Natl Acad Sci U S A. 2024;121:e2414501121.
    PubMed     Abstract available


  22. ARULRAJ T, Wang H, Deshpande A, Varadhan R, et al
    Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade.
    Proc Natl Acad Sci U S A. 2024;121:e2410911121.
    PubMed     Abstract available


    October 2024
  23. LI C, Kaur A, Pavlidaki A, Spenle C, et al
    Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2404485121.
    PubMed     Abstract available


  24. BALDASSARRI I, Tavakol DN, Graney PL, Chramiec AG, et al
    An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche.
    Proc Natl Acad Sci U S A. 2024;121:e2405257121.
    PubMed     Abstract available



  25. Correction for Zhang et al., HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
    Proc Natl Acad Sci U S A. 2024;121:e2418194121.
    PubMed    


  26. ASEMOTA S, Effah W, Holt J, Johnson D, et al
    A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity.
    Proc Natl Acad Sci U S A. 2024;121:e2406837121.
    PubMed     Abstract available


    September 2024
  27. FENG X, Yang C, Huang Y, Su D, et al
    In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2406325121.
    PubMed     Abstract available


    August 2024
  28. CHIANG HC, Qi L, Mitra P, Huang Y, et al
    R-loop functions in Brca1-associated mammary tumorigenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2403600121.
    PubMed     Abstract available


    July 2024
  29. SHAH OS, Nasrazadani A, Foldi J, Atkinson JM, et al
    Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
    Proc Natl Acad Sci U S A. 2024;121:e2322068121.
    PubMed     Abstract available


  30. ZIN I, China A, Khan K, Nag JK, et al
    AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2303642121.
    PubMed     Abstract available


  31. ZHOU Q, Yu H, Chen Y, Ren J, et al
    The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11.
    Proc Natl Acad Sci U S A. 2024;121:e2320655121.
    PubMed     Abstract available


    June 2024
  32. RUAN ML, Ni WX, Chu JCH, Lam TL, et al
    Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers.
    Proc Natl Acad Sci U S A. 2024;121:e2316615121.
    PubMed     Abstract available


    May 2024
  33. CHEN J, Liu X, Zou Y, Gong J, et al
    A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation.
    Proc Natl Acad Sci U S A. 2024;121:e2306776121.
    PubMed     Abstract available


  34. ASHOKAN A, Sarkar S, Kamran MZ, Surnar B, et al
    Simultaneous targeting of peripheral and brain tumors with a therapeutic nanoparticle to disrupt metabolic adaptability at both sites.
    Proc Natl Acad Sci U S A. 2024;121:e2318119121.
    PubMed     Abstract available


  35. GOYETTE MA, Stevens LE, DePinho CR, Seehawer M, et al
    Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Proc Natl Acad Sci U S A. 2024;121:e2322688121.
    PubMed     Abstract available


    April 2024
  36. MONDAL DK, Xie C, Pascal GJ, Buraschi S, et al
    Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.
    Proc Natl Acad Sci U S A. 2024;121:e2317760121.
    PubMed     Abstract available


    March 2024
  37. WANG D, Tang M, Zhang P, Yang K, et al
    Activation of ERbeta hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2306814121.
    PubMed     Abstract available


  38. TAYLOR-PHILLIPS S, Jenkinson D, Stinton C, Kunar MA, et al
    Fatigue and vigilance in medical experts detecting breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2309576121.
    PubMed     Abstract available


  39. LAMIA KA
    Telling time in tumor samples reveals diversity of clock disruption.
    Proc Natl Acad Sci U S A. 2024;121:e2401496121.
    PubMed    


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