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Articles published in Proc Natl Acad Sci U S A

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    July 2021
  1. UPTON R, Banuelos A, Feng D, Biswas T, et al
    Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  2. PRADHAN AK, Maji S, Bhoopathi P, Talukdar S, et al
    Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1beta.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  3. DING Y, Liu Y, Lee DK, Tong Z, et al
    Cell lineage tracing links ERalpha loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  4. WANG R, Godet I, Yang Y, Salman S, et al
    Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  5. WOLFSBERGER J, Sakil HAM, Zhou L, van Bree N, et al
    TAp73 represses NF-kappaB-mediated recruitment of tumor-associated macrophages in breast cancer.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  6. ZHANG Y, Xie X, Yeganeh PN, Lee DJ, et al
    Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    February 2021
  7. JIMENEZ-SANCHEZ J, Bosque JJ, Jimenez Londono GA, Molina-Garcia D, et al
    Evolutionary dynamics at the tumor edge reveal metabolic imaging biomarkers.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  8. WIJSHAKE T, Zou Z, Chen B, Zhong L, et al
    Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  9. CHANG PH, Chen MC, Tsai YP, Tan GYT, et al
    Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  10. DAMAGHI M, West J, Robertson-Tessi M, Xu L, et al
    The harsh microenvironment in early breast cancer selects for a Warburg phenotype.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  11. SURESH BM, Li W, Zhang P, Wang KW, et al
    A general fragment-based approach to identify and optimize bioactive ligands targeting RNA.
    Proc Natl Acad Sci U S A. 2020;117:33197-33203.
    PubMed     Abstract available


  12. GAO Y, Chen X, He Q, Gimple RC, et al
    Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
    Proc Natl Acad Sci U S A. 2020;117:33295-33304.
    PubMed     Abstract available


  13. NOGALSKI MT, Shenk T
    HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement.
    Proc Natl Acad Sci U S A. 2020;117:31891-31901.
    PubMed     Abstract available


  14. KIM O, Park EY, Kwon SY, Shin S, et al
    Targeting progesterone signaling prevents metastatic ovarian cancer.
    Proc Natl Acad Sci U S A. 2020 Dec 1. pii: 2013595117.
    PubMed     Abstract available


    November 2020
  15. BARONE M, Muller M, Chiha S, Ren J, et al
    Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
    Proc Natl Acad Sci U S A. 2020 Nov 12. pii: 2007213117.
    PubMed     Abstract available


  16. WEAVER VM, Bissell MJ
    Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.
    Proc Natl Acad Sci U S A. 2020;117:27759-27760.
    PubMed    


    October 2020
  17. XUAN B, Ghosh D, Jiang J, Shao R, et al
    Vimentin filaments drive migratory persistence in polyploidal cancer cells.
    Proc Natl Acad Sci U S A. 2020;117:26756-26765.
    PubMed     Abstract available


  18. YANG PB, Hou PP, Liu FY, Hong WB, et al
    Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
    Proc Natl Acad Sci U S A. 2020 Oct 21. pii: 2002997117.
    PubMed     Abstract available


  19. PRATT SJP, Lee RM, Chang KT, Hernandez-Ochoa EO, et al
    Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca(2+) signals that are inhibited by oncogenic KRas.
    Proc Natl Acad Sci U S A. 2020;117:26008-26019.
    PubMed     Abstract available


  20. LOEILLET S, Herzog M, Puddu F, Legoix P, et al
    Trajectory and uniqueness of mutational signatures in yeast mutators.
    Proc Natl Acad Sci U S A. 2020;117:24947-24956.
    PubMed     Abstract available


    September 2020
  21. SPANGLE JM, Von T, Pavlick DC, Khotimsky A, et al
    PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-alpha inhibition.
    Proc Natl Acad Sci U S A. 2020;117:24427-24433.
    PubMed     Abstract available


  22. CHEN IX, Newcomer K, Pauken KE, Juneja VR, et al
    A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
    Proc Natl Acad Sci U S A. 2020;117:23684-23694.
    PubMed     Abstract available


    August 2020
  23. KHATIB A, Solaimuthu B, Ben Yosef M, Abu Rmaileh A, et al
    The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
    Proc Natl Acad Sci U S A. 2020 Aug 18. pii: 2010275117.
    PubMed     Abstract available


    July 2020
  24. MCLAUGHLIN LJ, Stojanovic L, Kogan AA, Rutherford JL, et al
    Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.
    Proc Natl Acad Sci U S A. 2020;117:17785-17795.
    PubMed     Abstract available


  25. CALLMANN CE, Cole LE, Kusmierz CD, Huang Z, et al
    Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2020 Jul 15. pii: 2005794117.
    PubMed     Abstract available


  26. ZERVANTONAKIS IK, Poskus MD, Scott AL, Selfors LM, et al
    Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
    Proc Natl Acad Sci U S A. 2020;117:16500-16508.
    PubMed     Abstract available


    June 2020
  27. GRAVES JD, Lee YJ, Liu K, Li G, et al
    E2F1 sumoylation as a protective cellular mechanism in oxidative stress response.
    Proc Natl Acad Sci U S A. 2020;117:14958-14969.
    PubMed     Abstract available


  28. ZHU N, Zhang J, Du Y, Qin X, et al
    Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer.
    Proc Natl Acad Sci U S A. 2020 Jun 12. pii: 1910278117.
    PubMed     Abstract available


    April 2020
  29. LEE S, Hu Y, Loo SK, Tan Y, et al
    Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2020 Apr 22. pii: 1921333117.
    PubMed     Abstract available


  30. CARVAJAL-GARCIA J, Cho JE, Carvajal-Garcia P, Feng W, et al
    Mechanistic basis for microhomology identification and genome scarring by polymerase theta.
    Proc Natl Acad Sci U S A. 2020;117:8476-8485.
    PubMed     Abstract available


  31. LEUNG KK, Wilson GM, Kirkemo LL, Riley NM, et al
    Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes.
    Proc Natl Acad Sci U S A. 2020;117:7764-7775.
    PubMed     Abstract available


  32. KUMAR S, Singh SK, Viswakarma N, Sondarva G, et al
    Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
    Proc Natl Acad Sci U S A. 2020;117:7961-7970.
    PubMed     Abstract available


    March 2020
  33. YI Y, Chen D, Ao J, Zhang W, et al
    Transcriptional suppression of AMPKalpha1 promotes breast cancer metastasis upon oncogene activation.
    Proc Natl Acad Sci U S A. 2020 Mar 19. pii: 1914786117.
    PubMed     Abstract available


  34. NA TY, Schecterson L, Mendonsa AM, Gumbiner BM, et al
    The functional activity of E-cadherin controls tumor cell metastasis at multiple steps.
    Proc Natl Acad Sci U S A. 2020;117:5931-5937.
    PubMed     Abstract available


  35. PHILLIPS JW, Pan Y, Tsai BL, Xie Z, et al
    Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers.
    Proc Natl Acad Sci U S A. 2020;117:5269-5279.
    PubMed     Abstract available


  36. KESAVAN R, Fromel T, Zukunft S, Laban H, et al
    Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
    Proc Natl Acad Sci U S A. 2020 Mar 2. pii: 1921381117.
    PubMed     Abstract available


    February 2020
  37. SCHNELL M, Mittal S, Falahkheirkhah K, Mittal A, et al
    All-digital histopathology by infrared-optical hybrid microscopy.
    Proc Natl Acad Sci U S A. 2020;117:3388-3396.
    PubMed     Abstract available


  38. BRANDT AC, McNally L, Lorimer EL, Unger B, et al
    Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.
    Proc Natl Acad Sci U S A. 2020;117:3627-3636.
    PubMed     Abstract available


  39. XIONG G, Chen J, Zhang G, Wang S, et al
    Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.
    Proc Natl Acad Sci U S A. 2020;117:3748-3758.
    PubMed     Abstract available


  40. COSTALES MG, Aikawa H, Li Y, Childs-Disney JL, et al
    Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
    Proc Natl Acad Sci U S A. 2020;117:2406-2411.
    PubMed     Abstract available


    January 2020
  41. PUGACHEVA EM, Kubo N, Loukinov D, Tajmul M, et al
    CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention.
    Proc Natl Acad Sci U S A. 2020;117:2020-2031.
    PubMed     Abstract available


  42. GALLAGHER FA, Woitek R, McLean MA, Gill AB, et al
    Imaging breast cancer using hyperpolarized carbon-13 MRI.
    Proc Natl Acad Sci U S A. 2020 Jan 21. pii: 1913841117.
    PubMed     Abstract available


  43. BLOCKHUYS S, Zhang X, Wittung-Stafshede P
    Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration.
    Proc Natl Acad Sci U S A. 2020 Jan 13. pii: 1910722117.
    PubMed     Abstract available


  44. WINKLER I, Bitter C, Winkler S, Weichenhan D, et al
    Identification of Ppargamma-modulated miRNA hubs that target the fibrotic tumor microenvironment.
    Proc Natl Acad Sci U S A. 2020;117:454-463.
    PubMed     Abstract available


  45. LIN CW, Xie J, Zhang D, Han KH, et al
    Immunity against cancer cells may promote their proliferation and metastasis.
    Proc Natl Acad Sci U S A. 2020;117:426-431.
    PubMed     Abstract available


    December 2019
  46. GREENE KS, Lukey MJ, Wang X, Blank B, et al
    SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
    Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1911954116.
    PubMed     Abstract available


  47. FU X, Pereira R, De Angelis C, Veeraraghavan J, et al
    FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer.
    Proc Natl Acad Sci U S A. 2019 Dec 11. pii: 1911584116.
    PubMed     Abstract available


  48. BANERJEE S, Wei T, Wang J, Lee JJ, et al
    Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.
    Proc Natl Acad Sci U S A. 2019;116:24881-24891.
    PubMed     Abstract available


    November 2019
  49. HJELMELAND AB, Patel RP
    SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer.
    Proc Natl Acad Sci U S A. 2019;116:23376-23378.
    PubMed    


  50. YOU S, Barkalifa R, Chaney EJ, Tu H, et al
    Label-free visualization and characterization of extracellular vesicles in breast cancer.
    Proc Natl Acad Sci U S A. 2019 Nov 15. pii: 1909243116.
    PubMed     Abstract available


  51. RODRIGUES-FERREIRA S, Nehlig A, Moindjie H, Monchecourt C, et al
    Improving breast cancer sensitivity to paclitaxel by increasing aneuploidy.
    Proc Natl Acad Sci U S A. 2019 Nov 4. pii: 1910824116.
    PubMed     Abstract available


    October 2019
  52. KREUZALER P, Clarke MA, Brown EJ, Wilson CH, et al
    Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.
    Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 1903485116.
    PubMed     Abstract available


  53. HAGERLING C, Gonzalez H, Salari K, Wang CY, et al
    Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer.
    Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 1907660116.
    PubMed     Abstract available


  54. HE C, Danes JM, Hart PC, Zhu Y, et al
    SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.
    Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 1902308116.
    PubMed     Abstract available


    May 2019
  55. MOROTTI M, Bridges E, Valli A, Choudhry H, et al
    Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
    Proc Natl Acad Sci U S A. 2019 May 31. pii: 1818521116.
    PubMed     Abstract available



  56. Correction for Kroger et al., Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells.
    Proc Natl Acad Sci U S A. 2019 May 28. pii: 1907473116.
    PubMed    


  57. BAI J, Wu K, Cao MH, Yang Y, et al
    SCF(FBXO22) targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis.
    Proc Natl Acad Sci U S A. 2019 May 28. pii: 1820990116.
    PubMed     Abstract available


    April 2019
  58. VERMA S, Yeddula N, Soda Y, Zhu Q, et al
    BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling.
    Proc Natl Acad Sci U S A. 2019;116:7363-7370.
    PubMed     Abstract available


  59. SHANBHAG V, Jasmer-McDonald K, Zhu S, Martin AL, et al
    ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis.
    Proc Natl Acad Sci U S A. 2019;116:6836-6841.
    PubMed     Abstract available


    March 2019
  60. ZHANG J, Goliwas KF, Wang W, Taufalele PV, et al
    Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells.
    Proc Natl Acad Sci U S A. 2019 Mar 28. pii: 1809964116.
    PubMed     Abstract available


  61. CROW M, Lim N, Ballouz S, Pavlidis P, et al
    Predictability of human differential gene expression.
    Proc Natl Acad Sci U S A. 2019;116:6491-6500.
    PubMed     Abstract available


  62. KROGER C, Afeyan A, Mraz J, Eaton EN, et al
    Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells.
    Proc Natl Acad Sci U S A. 2019 Mar 25. pii: 1812876116.
    PubMed     Abstract available



  63. Correction for Blasco-Benito et al., Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.
    Proc Natl Acad Sci U S A. 2019 Mar 18. pii: 1903209116.
    PubMed    


    February 2019
  64. CHUANG PK, Hsiao M, Hsu TL, Chang CF, et al
    Signaling pathway of globo-series glycosphingolipids and beta1,3-galactosyltransferase V (beta3GalT5) in breast cancer.
    Proc Natl Acad Sci U S A. 2019;116:3518-3523.
    PubMed     Abstract available


  65. ONDECK MG, Kumar A, Placone JK, Plunkett CM, et al
    Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling.
    Proc Natl Acad Sci U S A. 2019;116:3502-3507.
    PubMed     Abstract available


  66. JIA D, Lu M, Jung KH, Park JH, et al
    Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways.
    Proc Natl Acad Sci U S A. 2019;116:3909-3918.
    PubMed     Abstract available


  67. SLEDGE GW
    Targeting CXCR4-induced desmoplasia to improve checkpoint inhibition in breast cancer.
    Proc Natl Acad Sci U S A. 2019 Feb 22. pii: 1900368116.
    PubMed    


  68. VOUTOURI C, Kirkpatrick ND, Chung E, Mpekris F, et al
    Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.
    Proc Natl Acad Sci U S A. 2019;116:2662-2671.
    PubMed     Abstract available


  69. LI X, Gruosso T, Zuo D, Omeroglu A, et al
    Infiltration of CD8(+) T cells into tumor cell clusters in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2019 Feb 7. pii: 1817652116.
    PubMed     Abstract available


  70. BLASCO-BENITO S, Moreno E, Seijo-Vila M, Tundidor I, et al
    Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.
    Proc Natl Acad Sci U S A. 2019 Feb 7. pii: 1815034116.
    PubMed     Abstract available


  71. KUBLI SP, Bassi C, Roux C, Wakeham A, et al
    AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.
    Proc Natl Acad Sci U S A. 2019 Feb 7. pii: 1815126116.
    PubMed     Abstract available


    January 2019
  72. CHEN IX, Chauhan VP, Posada J, Ng MR, et al
    Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
    Proc Natl Acad Sci U S A. 2019 Jan 30. pii: 1815515116.
    PubMed     Abstract available


  73. KOBOLD S
    Innate and adaptive immunity combined for cancer treatment.
    Proc Natl Acad Sci U S A. 2019;116:1087-1088.
    PubMed    


  74. ZHANG S, Zhang H, Ghia EM, Huang J, et al
    Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.
    Proc Natl Acad Sci U S A. 2019 Jan 8. pii: 1816262116.
    PubMed     Abstract available


    December 2018
  75. TOMINAGA K, Minato H, Murayama T, Sasahara A, et al
    Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
    Proc Natl Acad Sci U S A. 2018 Dec 26. pii: 1806851116.
    PubMed     Abstract available


  76. BOCCI F, Gearhart-Serna L, Boareto M, Ribeiro M, et al
    Toward understanding cancer stem cell heterogeneity in the tumor microenvironment.
    Proc Natl Acad Sci U S A. 2018 Dec 26. pii: 1815345116.
    PubMed     Abstract available


  77. KAPLANOV I, Carmi Y, Kornetsky R, Shemesh A, et al
    Blocking IL-1beta reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
    Proc Natl Acad Sci U S A. 2018 Dec 13. pii: 1812266115.
    PubMed     Abstract available


  78. TOKUYAMA M, Kong Y, Song E, Jayewickreme T, et al
    ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses.
    Proc Natl Acad Sci U S A. 2018;115:12565-12572.
    PubMed     Abstract available


  79. LIU C, Sun L, Yang J, Liu T, et al
    FSIP1 regulates autophagy in breast cancer.
    Proc Natl Acad Sci U S A. 2018 Dec 3. pii: 1809681115.
    PubMed     Abstract available


    November 2018
  80. MATSUNUMA R, Chan DW, Kim BJ, Singh P, et al
    DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.
    Proc Natl Acad Sci U S A. 2018 Nov 29. pii: 1810598115.
    PubMed     Abstract available


    October 2018
  81. SUN XX, Chen Y, Su Y, Wang X, et al
    SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.
    Proc Natl Acad Sci U S A. 2018;115:10983-10988.
    PubMed     Abstract available


  82. LIANG W, Li Q, Ferrara N
    Metastatic growth instructed by neutrophil-derived transferrin.
    Proc Natl Acad Sci U S A. 2018;115:11060-11065.
    PubMed     Abstract available


    September 2018
  83. REESE JM, Bruinsma ES, Nelson AW, Chernukhin I, et al
    ERbeta-mediated induction of cystatins results in suppression of TGFbeta signaling and inhibition of triple-negative breast cancer metastasis.
    Proc Natl Acad Sci U S A. 2018 Sep 26. pii: 1807751115.
    PubMed     Abstract available


  84. GURYEV EL, Volodina NO, Shilyagina NY, Gudkov SV, et al
    Radioactive ((90)Y) upconversion nanoparticles conjugated with recombinant targeted toxin for synergistic nanotheranostics of cancer.
    Proc Natl Acad Sci U S A. 2018;115:9690-9695.
    PubMed     Abstract available


  85. LAN J, Lu H, Samanta D, Salman S, et al
    Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment.
    Proc Natl Acad Sci U S A. 2018 Sep 21. pii: 1809695115.
    PubMed     Abstract available


  86. CHU B, He A, Tian Y, He W, et al
    Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples.
    Proc Natl Acad Sci U S A. 2018;115:E8863-E8872.
    PubMed     Abstract available


    August 2018
  87. ARVANITIS CD, Askoxylakis V, Guo Y, Datta M, et al
    Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
    Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 1807105115.
    PubMed     Abstract available


  88. GRITHER WR, Longmore GD
    Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain.
    Proc Natl Acad Sci U S A. 2018;115:E7786-E7794.
    PubMed     Abstract available


  89. DATTA S, Misra SK, Saha ML, Lahiri N, et al
    Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells.
    Proc Natl Acad Sci U S A. 2018;115:8087-8092.
    PubMed     Abstract available


  90. FOULDS CE
    Disrupting a negative feedback loop drives endocrine therapy-resistant breast cancer.
    Proc Natl Acad Sci U S A. 2018 Aug 6. pii: 1811263115.
    PubMed    


    July 2018
  91. REN C, Zhang G, Han F, Fu S, et al
    Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
    Proc Natl Acad Sci U S A. 2018;115:7949-7954.
    PubMed     Abstract available


  92. WANG B, Li D, Kovalchuk I, Apel IJ, et al
    miR-34a directly targets tRNAi(Met) precursors and affects cellular proliferation, cell cycle, and apoptosis.
    Proc Natl Acad Sci U S A. 2018;115:7392-7397.
    PubMed     Abstract available


  93. XIAO T, Li W, Wang X, Xu H, et al
    Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.
    Proc Natl Acad Sci U S A. 2018 Jul 9. pii: 1722617115.
    PubMed     Abstract available


  94. LEE JJ, van de Ven RAH, Zaganjor E, Ng MR, et al
    Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.
    Proc Natl Acad Sci U S A. 2018;115:7057-7062.
    PubMed     Abstract available


    June 2018
  95. MITTAL S, Yeh K, Leslie LS, Kenkel S, et al
    Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology.
    Proc Natl Acad Sci U S A. 2018;115:E5651-E5660.
    PubMed     Abstract available


  96. SUN X, Wang X, Tang Z, Grivainis M, et al
    Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression.
    Proc Natl Acad Sci U S A. 2018;115:E5526-E5535.
    PubMed     Abstract available


  97. DE SEMIR D, Bezrookove V, Nosrati M, Dar AA, et al
    PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.
    Proc Natl Acad Sci U S A. 2018 Jun 4. pii: 1804779115.
    PubMed     Abstract available


    May 2018
  98. ROY B, Venkatachalapathy S, Ratna P, Wang Y, et al
    Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors.
    Proc Natl Acad Sci U S A. 2018;115:E4741-E4750.
    PubMed     Abstract available


  99. SEO A, Steinberg-Shemer O, Unal S, Casadei S, et al
    Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1.
    Proc Natl Acad Sci U S A. 2018;115:5241-5246.
    PubMed     Abstract available


  100. LAI X, Stiff A, Duggan M, Wesolowski R, et al
    Modeling combination therapy for breast cancer with BET and immune checkpoint inhibitors.
    Proc Natl Acad Sci U S A. 2018 May 7. pii: 1721559115.
    PubMed     Abstract available


    April 2018
  101. NAIR P, Vilcek J
    Profile of Alexander Y. Rudensky, winner of the 2018 Vilcek Prize in Biomedical Science.
    Proc Natl Acad Sci U S A. 2018;115:4301-4304.
    PubMed    


  102. VEGA-RUBIN-DE-CELIS S, Zou Z, Fernandez AF, Ci B, et al
    Increased autophagy blocks HER2-mediated breast tumorigenesis.
    Proc Natl Acad Sci U S A. 2018;115:4176-4181.
    PubMed     Abstract available


  103. ZHAO L, Huang S, Mei S, Yang Z, et al
    Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis.
    Proc Natl Acad Sci U S A. 2018;115:E3673-E3681.
    PubMed     Abstract available


    March 2018
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