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  Colorectal Neoplasms

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Articles published in Eur J Cancer

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Single Articles

    September 2020
  1. SOBRERO AF, Puccini A, Shi Q, Grothey A, et al
    A new prognostic and predictive tool for shared decision making in stage III colon cancer.
    Eur J Cancer. 2020;138:182-188.
    PubMed     Abstract available

    August 2020
  2. TSAI HL, Huang CW, Lin YW, Wang JH, et al
    Determination of the UGT1A1 polymorphism as guidance for irinotecan dose escalation in metastatic colorectal cancer treated with first-line bevacizumab and FOLFIRI (PURE FIST).
    Eur J Cancer. 2020;138:19-29.
    PubMed     Abstract available

  3. CARDONE C, Blauensteiner B, Moreno-Viedma V, Martini G, et al
    AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer.
    Eur J Cancer. 2020;138:1-10.
    PubMed     Abstract available

  4. STAHLER A, Stintzing S, von Einem JC, Westphalen CB, et al
    Single-nucleotide variants, tumour mutational burden and microsatellite instability in patients with metastatic colorectal cancer: Next-generation sequencing results of the FIRE-3 trial.
    Eur J Cancer. 2020;137:250-259.
    PubMed     Abstract available

  5. TEUFEL A, Gerken M, Furst A, Ebert M, et al
    Benefit of adjuvant chemotherapy in high-risk colon cancer: A 17-year population-based analysis of 6131 patients with Union for International Cancer Control stage II T4N0M0 colon cancer.
    Eur J Cancer. 2020;137:148-160.
    PubMed     Abstract available

  6. MARTIN-ROMANO P, Ammari S, El-Dakdoukti Y, Baldini C, et al
    Chemotherapy beyond immune checkpoint inhibitors in patients with metastatic colorectal cancer.
    Eur J Cancer. 2020;137:117-126.
    PubMed     Abstract available

  7. KURRECK A, Heinemann V, Fischer von Weikersthal L, Decker T, et al
    Impact of age on efficacy and early mortality of initial sequential treatment versus upfront combination chemotherapy in patients with metastatic colorectal cancer: a subgroup analysis of a phase III trial (AIO KRK0110, XELAVIRI study).
    Eur J Cancer. 2020;137:81-92.
    PubMed     Abstract available

    July 2020
  8. RAIMONDI A, Di Maio M, Morano F, Corallo S, et al
    Health-related quality of life in patients with RAS wild-type metastatic colorectal cancer treated with panitumumab-based first-line treatment strategy: A pre-specified secondary analysis of the Valentino study.
    Eur J Cancer. 2020;135:230-239.
    PubMed     Abstract available

    June 2020
  9. SAKAI D, Taniguchi H, Sugimoto N, Tamura T, et al
    Randomised phase II study of panitumumab plus irinotecan versus cetuximab plus irinotecan in patients with KRAS wild-type metastatic colorectal cancer refractory to fluoropyrimidine, irinotecan and oxaliplatin (WJOG 6510G).
    Eur J Cancer. 2020;135:11-21.
    PubMed     Abstract available

    May 2020
  10. PASQUALETTI G, Schirripa M, Dochy E, Fassan M, et al
    Thyroid hormones ratio is a major prognostic marker in advanced metastatic colorectal cancer: Results from the phase III randomised CORRECT trial.
    Eur J Cancer. 2020;133:66-73.
    PubMed     Abstract available

    April 2020
  11. BERGER MD, Ning Y, Stintzing S, Heinemann V, et al
    A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials.
    Eur J Cancer. 2020;131:89-97.
    PubMed     Abstract available

    March 2020
  12. ZLOBEC I, Dawson HE, Blank A, Bokhorst JM, et al
    Are tumour grade and tumour budding equivalent in colorectal cancer? A retrospective analysis of 771 patients.
    Eur J Cancer. 2020;130:139-145.
    PubMed     Abstract available

  13. KLINKHAMMER-SCHALKE M, Steinger B, Koller M, Zeman F, et al
    Diagnosing deficits in quality of life and providing tailored therapeutic options: Results of a randomised trial in 220 patients with colorectal cancer.
    Eur J Cancer. 2020;130:102-113.
    PubMed     Abstract available

  14. COHEN R, Vernerey D, Bellera C, Meurisse A, et al
    Guidelines for time-to-event end-point definitions in adjuvant randomised trials for patients with localised colon cancer: Results of the DATECAN initiative.
    Eur J Cancer. 2020;130:63-71.
    PubMed     Abstract available

  15. KIM JW, Han SW, Cho JY, Chung IJ, et al
    Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial.
    Eur J Cancer. 2020;130:51-62.
    PubMed     Abstract available

    February 2020
  16. LUQUE-FERNANDEZ MA, Goncalves K, Salamanca-Fernandez E, Redondo-Sanchez D, et al
    Multimorbidity and short-term overall mortality among colorectal cancer patients in Spain: A population-based cohort study.
    Eur J Cancer. 2020;129:4-14.
    PubMed     Abstract available

    January 2020
  17. BHARDWAJ M, Weigl K, Tikk K, Holland-Letz T, et al
    Multiplex quantitation of 270 plasma protein markers to identify a signature for early detection of colorectal cancer.
    Eur J Cancer. 2020;127:30-40.
    PubMed     Abstract available

  18. FASTNER G, Sedlmayer F, Widder J, Metz M, et al
    Endocrine therapy with or without whole breast irradiation in low-risk breast cancer patients after breast-conserving surgery: 10-year results of the Austrian Breast and Colorectal Cancer Study Group 8A trial.
    Eur J Cancer. 2020;127:12-20.
    PubMed     Abstract available

  19. GINI A, Jansen EEL, Zielonke N, Meester RGS, et al
    Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review.
    Eur J Cancer. 2020 Jan 10. pii: S0959-8049(19)30870.
    PubMed     Abstract available

  20. ROMBOUTS AJM, Hugen N, Elferink MAG, Poortmans PMP, et al
    Increased risk for second primary rectal cancer after pelvic radiation therapy.
    Eur J Cancer. 2020;124:142-151.
    PubMed     Abstract available

    November 2019
  21. SUMMERS MG, Maughan TS, Kaplan R, Law PJ, et al
    Comprehensive analysis of colorectal cancer-risk loci and survival outcome: A prognostic role for CDH1 variants.
    Eur J Cancer. 2019;124:56-63.
    PubMed     Abstract available

  22. DUCREUX M, Petersen LN, Ohler L, Bergamo F, et al
    Safety and effectiveness of regorafenib in patients with metastatic colorectal cancer in routine clinical practice in the prospective, observational CORRELATE study.
    Eur J Cancer. 2019;123:146-154.
    PubMed     Abstract available

    October 2019
  23. SOLDEVILLA B, Carretero-Puche C, Gomez-Lopez G, Al-Shahrour F, et al
    The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications.
    Eur J Cancer. 2019;123:118-129.
    PubMed     Abstract available

    August 2019
  24. MUNEMOTO Y, Nakamura M, Takahashi M, Kotaka M, et al
    SAPPHIRE: a randomised phase II study of planned discontinuation or continuous treatment of oxaliplatin after six cycles of modified FOLFOX6 plus panitumumab in patients with colorectal cancer.
    Eur J Cancer. 2019;119:158-167.
    PubMed     Abstract available

  25. GALLOIS C, Artru P, Lievre A, Auclin E, et al
    Evaluation of two nutritional scores' association with systemic treatment toxicity and survival in metastatic colorectal cancer: an AGEO prospective multicentre study.
    Eur J Cancer. 2019;119:35-43.
    PubMed     Abstract available

    July 2019
  26. LOUPAKIS F, Intini R, Cremolini C, Orlandi A, et al
    A validated prognostic classifier for (V600E)BRAF-mutated metastatic colorectal cancer: the 'BRAF BeCool' study.
    Eur J Cancer. 2019;118:121-130.
    PubMed     Abstract available

  27. MILANO G
    More rationale for optimal sequencing of therapeutic monoclonal antibodies in metastatic colorectal cancer.
    Eur J Cancer. 2019;117:131-132.

    June 2019
  28. BROUWER NPM, Heil TC, Olde Rikkert MGM, Lemmens VEPP, et al
    The gap in postoperative outcome between older and younger patients with stage I-III colorectal cancer has been bridged; results from the Netherlands cancer registry.
    Eur J Cancer. 2019;116:1-9.
    PubMed     Abstract available

    May 2019
  29. VAUGHAN-SHAW PG, Zgaga L, Theodoratou E, Blackmur JP, et al
    Whether vitamin D supplementation protects against colorectal cancer risk remains an open question.
    Eur J Cancer. 2019;115:1-3.

    March 2019
  30. ARGILES G, Andre T, Hollebecque A, Calvo A, et al
    Phase I dose-escalation of trifluridine/tipiracil in combination with oxaliplatin in patients with metastatic colorectal cancer.
    Eur J Cancer. 2019;112:12-19.
    PubMed     Abstract available

  31. PUCCINI A, Loupakis F, Stintzing S, Cao S, et al
    Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.
    Eur J Cancer. 2019;111:138-147.
    PubMed     Abstract available

    February 2019
  32. KOSUMI K, Hamada T, Zhang S, Liu L, et al
    Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial.
    Eur J Cancer. 2019;111:82-93.
    PubMed     Abstract available

  33. CASCINU S, Poli D, Zaniboni A, Lonardi S, et al
    The prognostic impact of primary tumour location in patients with stage II and stage III colon cancer receiving adjuvant therapy. A GISCAD analysis from three large randomised trials.
    Eur J Cancer. 2019;111:1-7.
    PubMed     Abstract available

  34. ANDERSSON TM, Engholm G, Lund AQ, Lourenco S, et al
    Avoidable cancers in the Nordic countries-the potential impact of increased physical activity on postmenopausal breast, colon and endometrial cancer.
    Eur J Cancer. 2019;110:42-48.
    PubMed     Abstract available

  35. CREMOLINI C, Marmorino F, Bergamo F, Aprile G, et al
    Phase II randomised study of maintenance treatment with bevacizumab or bevacizumab plus metronomic chemotherapy after first-line induction with FOLFOXIRI plus Bevacizumab for metastatic colorectal cancer patients: the MOMA trial.
    Eur J Cancer. 2019;109:175-182.
    PubMed     Abstract available

    January 2019
  36. MODEST DP, Pant S, Sartore-Bianchi A
    Treatment sequencing in metastatic colorectal cancer.
    Eur J Cancer. 2019;109:70-83.
    PubMed     Abstract available

    December 2018
  37. SCHWARTZ S, Szeto C, Tian Y, Cecchi F, et al
    Refining the selection of patients with metastatic colorectal cancer for treatment with temozolomide using proteomic analysis of O6-methylguanine-DNA-methyltransferase.
    Eur J Cancer. 2018;107:164-174.
    PubMed     Abstract available

  38. SUENAGA M, Stintzing S, Cao S, Zhang W, et al
    Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial.
    Eur J Cancer. 2018;107:100-114.
    PubMed     Abstract available

    November 2018
  39. HOLCH JW, Ricard I, Stintzing S, Fischer von Weikersthal L, et al
    Relevance of baseline carcinoembryonic antigen for first-line treatment against metastatic colorectal cancer with FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial).
    Eur J Cancer. 2018;106:115-125.
    PubMed     Abstract available

  40. BARANISKIN A, Buchberger B, Pox C, Graeven U, et al
    Efficacy of bevacizumab in first-line treatment of metastatic colorectal cancer: A systematic review and meta-analysis.
    Eur J Cancer. 2018;106:37-44.
    PubMed     Abstract available

  41. IMANISHI M, Yamamoto Y, Hamano Y, Yamada T, et al
    Efficacy of adjuvant chemotherapy after resection of pulmonary metastasis from colorectal cancer: a propensity score-matched analysis.
    Eur J Cancer. 2018;106:69-77.
    PubMed     Abstract available

    October 2018
    Synergistic activity of dasatinib in combination with beta-catenin blockade in colorectal cancer cells.
    Eur J Cancer. 2018 Oct 12. pii: S0959-8049(18)31366.

    September 2018
  43. SALEM ME, Yin J, Weinberg BA, Renfro LA, et al
    Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD dat
    Eur J Cancer. 2018;103:205-213.
    PubMed     Abstract available

  44. LORD AC, D'Souza N, Pucher PH, Moran BJ, et al
    Author response to comment on 'significance of extranodal tumour deposits in colorectal cancer: A systematic review and meta-analysis'.
    Eur J Cancer. 2018 Sep 25. pii: S0959-8049(18)31336.

  45. GOOTJES EC, Bakkerus L, Ten Tije AJ, Witteveen PO, et al
    The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer.
    Eur J Cancer. 2018;103:160-164.
    PubMed     Abstract available

  46. HAMADA T, Liu L, Nowak JA, Mima K, et al
    Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
    Eur J Cancer. 2018;103:98-107.
    PubMed     Abstract available

  47. HIRST Y, Stoffel S, Baio G, McGregor L, et al
    Uptake of the English Bowel (Colorectal) Cancer Screening Programme: an update 5 years after the full roll-out.
    Eur J Cancer. 2018 Sep 6. pii: S0959-8049(18)31120.
    PubMed     Abstract available

    August 2018
  48. MADI A, Fisher D, Maughan TS, Colley JP, et al
    Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.
    Eur J Cancer. 2018;102:31-39.
    PubMed     Abstract available

  49. TEJPAR S, Yan P, Piessevaux H, Dietrich D, et al
    Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial.
    Eur J Cancer. 2018;99:66-77.
    PubMed     Abstract available

    July 2018
  50. ARANDA E, Garcia Alfonso P, Benavides M, Sanchez Ruiz A, et al
    First-line mFOLFOX plus cetuximab followed by mFOLFOX plus cetuximab or single-agent cetuximab as maintenance therapy in patients with metastatic colorectal cancer: Phase II randomised MACRO2 TTD study.
    Eur J Cancer. 2018 Jul 24. pii: S0959-8049(18)30938.
    PubMed     Abstract available

  51. HEGEWISCH-BECKER S, Nopel-Dunnebacke S, Hinke A, Graeven U, et al
    Impact of primary tumour location and RAS/BRAF mutational status in metastatic colorectal cancer treated with first-line regimens containing oxaliplatin and bevacizumab: Prognostic factors from the AIO KRK0207 first-line and maintenance therapy trial.
    Eur J Cancer. 2018;101:105-113.
    PubMed     Abstract available

  52. GELLI M, Huguenin JFL, de Baere T, Benhaim L, et al
    Peritoneal and extraperitoneal relapse after previous curative treatment of peritoneal metastases from colorectal cancer: What survival can we expect?
    Eur J Cancer. 2018;100:94-103.
    PubMed     Abstract available

    June 2018
  53. GOEY KKH, Sorbye H, Glimelius B, Adams RA, et al
    Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group.
    Eur J Cancer. 2018;100:35-45.
    PubMed     Abstract available

  54. STOCKER G, Hacker UT, Fiteni F, John Mahachie J, et al
    Clinical consequences of chemotherapy dose reduction in obese patients with stage III colon cancer: A retrospective analysis from the PETACC 3 study.
    Eur J Cancer. 2018;99:49-57.
    PubMed     Abstract available

    May 2018
  55. APARICIO T, Ducreux M, Faroux R, Barbier E, et al
    Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials.
    Eur J Cancer. 2018;98:1-9.
    PubMed     Abstract available

  56. APARICIO T, Bouche O, Francois E, Retornaz F, et al
    Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer.
    Eur J Cancer. 2018;97:16-24.
    PubMed     Abstract available

  57. AUCLIN E, Andre T, Taieb J, Benetkiewicz M, et al
    Low-level postoperative carcinoembryonic antigen improves survival outcomes stratification in patients with stage II colon cancer treated with standard adjuvant treatments.
    Eur J Cancer. 2018 May 3. pii: S0959-8049(18)30782.

  58. GOEY KKH, Mahmoud R, Sorbye H, Glimelius B, et al
    Reporting of patient characteristics and stratification factors in phase 3 trials investigating first-line systemic treatment of metastatic colorectal cancer: A systematic review.
    Eur J Cancer. 2018;96:115-124.
    PubMed     Abstract available

    April 2018
  59. MARGALIT O, Mamtani R, Yang YX, Reiss KA, et al
    A new look at the International Duration Evaluation of Adjuvant therapy (IDEA) classification-Defining novel predictive and prognostic markers in stage III colon cancer.
    Eur J Cancer. 2018;96:105-110.
    PubMed     Abstract available

  60. MATSUDA C, Ishiguro M, Teramukai S, Kajiwara Y, et al
    A randomised-controlled trial of 1-year adjuvant chemotherapy with oral tegafur-uracil versus surgery alone in stage II colon cancer: SACURA trial.
    Eur J Cancer. 2018;96:54-63.
    PubMed     Abstract available

    March 2018
  61. TACHON G, Frouin E, Karayan-Tapon L, Auriault ML, et al
    Heterogeneity of mismatch repair defect in colorectal cancer and its implications in clinical practice.
    Eur J Cancer. 2018 Mar 5. pii: S0959-8049(18)30121.

  62. MARGALIT O, Mamtani R, Yang YX, Reiss KA, et al
    Assessing the prognostic value of carcinoembryonic antigen levels in stage I and II colon cancer.
    Eur J Cancer. 2018;94:1-5.
    PubMed     Abstract available

  63. OGURA A, Akiyoshi T, Yamamoto N, Kawachi H, et al
    Pattern of programmed cell death-ligand 1 expression and CD8-positive T-cell infiltration before and after chemoradiotherapy in rectal cancer.
    Eur J Cancer. 2018;91:11-20.
    PubMed     Abstract available

    February 2018
  64. YOSHINO T, Hsu Y, Nasroulah F
    Response to Letter to the Editor, 'Pharmacokinetics partly explains the relationship between CEA level and survival of colorectal cancer patients treated with ramucirumab,' by Ibrahim et al.
    Eur J Cancer. 2018 Feb 9. pii: S0959-8049(18)30084.

  65. ZOU D, Lou J, Ke J, Mei S, et al
    Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression.
    Eur J Cancer. 2018;93:1-9.
    PubMed     Abstract available

    January 2018
  66. VAN ROOIJEN KL, Shi Q, Goey KKH, Meyers J, et al
    Prognostic value of primary tumour resection in synchronous metastatic colorectal cancer: Individual patient data analysis of first-line randomised trials from the ARCAD database.
    Eur J Cancer. 2018;91:99-106.
    PubMed     Abstract available

  67. IBRAHIM S, Raoul W, Lecomte T, Paintaud G, et al
    Pharmacokinetics partly explains the relationship between carcinoembryonic antigen level and survival of colorectal cancer patients treated with ramucirumab.
    Eur J Cancer. 2018 Jan 9. pii: S0959-8049(17)31461.

  68. VON MOOS R, Koeberle D, Schacher S, Hayoz S, et al
    Neoadjuvant radiotherapy combined with capecitabine and sorafenib in patients with advanced KRAS-mutated rectal cancer: A phase I/II trial (SAKK 41/08).
    Eur J Cancer. 2018;89:82-89.
    PubMed     Abstract available

  69. SWETS M, Kuppen PJK, Blok EJ, Gelderblom H, et al
    Are pathological high-risk features in locally advanced rectal cancer a useful selection tool for adjuvant chemotherapy?
    Eur J Cancer. 2018;89:1-8.
    PubMed     Abstract available

    December 2017
  70. VAN CUTSEM E, Mayer RJ, Laurent S, Winkler R, et al
    The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer.
    Eur J Cancer. 2017;90:63-72.
    PubMed     Abstract available

    November 2017
  71. MODEST DP, Denecke T, Pratschke J, Ricard I, et al
    Surgical treatment options following chemotherapy plus cetuximab or bevacizumab in metastatic colorectal cancer-central evaluation of FIRE-3.
    Eur J Cancer. 2017;88:77-86.
    PubMed     Abstract available

  72. COHEN R, Buhard O, Cervera P, Hain E, et al
    Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency.
    Eur J Cancer. 2017;86:266-274.
    PubMed     Abstract available

    October 2017
  73. SUENAGA M, Schirripa M, Cao S, Zhang W, et al
    Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.
    Eur J Cancer. 2017;86:197-206.
    PubMed     Abstract available

  74. KEIKES L, Koopman M, Tanis PJ, Lemmens VEPP, et al
    Evaluating the scientific basis of quality indicators in colorectal cancer care: A systematic review.
    Eur J Cancer. 2017;86:166-177.
    PubMed     Abstract available

  75. PREVOSTEL C, Blache P
    The dose-dependent effect of SOX9 and its incidence in colorectal cancer.
    Eur J Cancer. 2017;86:150-157.
    PubMed     Abstract available

  76. MALKA D, Rotolo F, Boige V
    First-line treatment in metastatic colorectal cancer: Important or crucial?
    Eur J Cancer. 2017;84:363-366.

    September 2017
  77. TURATI F, Bravi F, Di Maso M, Bosetti C, et al
    Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and colorectal cancer risk.
    Eur J Cancer. 2017;85:86-94.
    PubMed     Abstract available

    August 2017
  78. KWAKMAN JJM, Baars A, van Zweeden AA, de Mol P, et al
    Case series of patients treated with the oral fluoropyrimidine S-1 after capecitabine-induced coronary artery vasospasm.
    Eur J Cancer. 2017;81:130-134.

    January 2017
  79. CHAN AK, Siriwardena AK
    Management of synchronous liver metastases and the recommendations of the second St. Gallen European Organisation for Research and Treatment of Cancer consensus conference on the management of rectal cancer.
    Eur J Cancer. 2017;71:51-52.

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