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Articles published in PLoS Comput Biol

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Single Articles


    December 2025
  1. LISOWSKI CM, King GM, Kosztin I
    Automated registration and clustering for enhanced localization atomic force microscopy of flexible membrane proteins.
    PLoS Comput Biol. 2025;21:e1013277.
    PubMed     Abstract available


  2. YANG L, Lu J, Wu X, Zhang X, et al
    Stable individualized brain computing model informed by spatiotemporal co-activity patterns.
    PLoS Comput Biol. 2025;21:e1013817.
    PubMed     Abstract available


  3. ZHANG L, Shi W, Zhao Z, Wang Z, et al
    Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics.
    PLoS Comput Biol. 2025;21:e1013822.
    PubMed     Abstract available


  4. BONTE T, Pourcelot O, Safieddine A, Slimani F, et al
    A deep learning approach for time-consistent cell cycle phase prediction from microscopy data.
    PLoS Comput Biol. 2025;21:e1013800.
    PubMed     Abstract available


  5. MARRAZZO G, De Martino F, Mukovskiy A, Giese MA, et al
    Neural encoding of biomechanically (im)possible human movements in occipitotemporal cortex.
    PLoS Comput Biol. 2025;21:e1013694.
    PubMed     Abstract available


    November 2025
  6. LIARDI A, Rosas FE, Carhart-Harris RL, Blackburne G, et al
    Null models for comparing information decomposition across complex systems.
    PLoS Comput Biol. 2025;21:e1013629.
    PubMed     Abstract available


  7. GAUTHAMAN RM, Menard B, Bonner MF
    Universal scale-free representations in human visual cortex.
    PLoS Comput Biol. 2025;21:e1013714.
    PubMed     Abstract available


  8. VARLEY TF, Mediano PAM, Patania A, Bongard J, et al
    The topology of synergy: Linking topological and information-theoretic approaches to higher-order interactions in complex systems.
    PLoS Comput Biol. 2025;21:e1013649.
    PubMed     Abstract available


    October 2025
  9. GATICA M, Atkinson-Clement C, Coronel-Oliveros C, Alkhawashki M, et al
    Understanding the high-order network plasticity mechanisms of ultrasound neuromodulation.
    PLoS Comput Biol. 2025;21:e1013514.
    PubMed     Abstract available


  10. LACHUER H, Moebel E, Mace AS, Masson A, et al
    Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy.
    PLoS Comput Biol. 2025;21:e1013556.
    PubMed     Abstract available


  11. RAIOLA M, Esteban I, Ivanovitch K, Sendra M, et al
    A method for analysing tissue motion and deformation during mammalian organogenesis.
    PLoS Comput Biol. 2025;21:e1013275.
    PubMed     Abstract available


  12. CHANG J, Yang Z, Zhou C
    Simultaneously determining regional heterogeneity and connection directionality from neural activity and symmetric connection.
    PLoS Comput Biol. 2025;21:e1013612.
    PubMed     Abstract available


  13. LEHUE F, Coronel-Oliveros C, Medel V, Liebe T, et al
    Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study.
    PLoS Comput Biol. 2025;21:e1012852.
    PubMed     Abstract available


  14. HIMMELBERG MM, Kwak Y, Carrasco M, Winawer J, et al
    Unpacking the V1 map: Differential covariation of preferred spatial frequency and cortical magnification across spatial dimensions.
    PLoS Comput Biol. 2025;21:e1013599.
    PubMed     Abstract available


  15. TIROUMALECHETTY A, Frankel EB, Kurshan PT
    WormSNAP: A software for fast, accurate, and unbiased detection of fluorescent puncta in C. elegans.
    PLoS Comput Biol. 2025;21:e1013643.
    PubMed     Abstract available


    September 2025
  16. PATTON A, Davidsen J
    Changing cognitive chimera states in human brain networks with age: Variations in cognitive integration and segregation.
    PLoS Comput Biol. 2025;21:e1013093.
    PubMed     Abstract available


  17. CALKA M, Badin P, Nazari MA, Rochette M, et al
    The G-OBIM tongue model: An accurate open-source biomechanical model of a male human tongue.
    PLoS Comput Biol. 2025;21:e1013378.
    PubMed     Abstract available


  18. ST-YVES G, Kay K, Naselaris T
    Variation in the geometry of concept manifolds across human visual cortex.
    PLoS Comput Biol. 2025;21:e1013416.
    PubMed     Abstract available


  19. XU Y, Prat CS, Sense F, van Rijn H, et al
    Default mode network connectivity predicts individual differences in long-term forgetting: Evidence for storage degradation, not retrieval failure.
    PLoS Comput Biol. 2025;21:e1013485.
    PubMed     Abstract available


  20. JACOB LPL, Bailes SM, Williams SD, Stringer C, et al
    Brainwide hemodynamics predict EEG neural rhythms across sleep and wakefulness in humans.
    PLoS Comput Biol. 2025;21:e1013497.
    PubMed     Abstract available


  21. PRADELLI F, Minervini G, Venkatesh P, Azad S, et al
    Mathematical modeling and simulation of tumor-induced angiogenesis in retinal hemangioblastoma.
    PLoS Comput Biol. 2025;21:e1012799.
    PubMed     Abstract available


    August 2025
  22. KRUPER J, Richie-Halford A, Qiao J, Gilmore A, et al
    A software ecosystem for brain tractometry processing, analysis, and insight.
    PLoS Comput Biol. 2025;21:e1013323.
    PubMed     Abstract available


  23. LI L, Uriyanghai U, Wai C, Yuan H, et al
    Temporal evolution of hemodynamics in murine arteriovenous fistula: A micro-CT based CFD study.
    PLoS Comput Biol. 2025;21:e1012985.
    PubMed     Abstract available


    July 2025
  24. KAYYALI M, Minchole A, Qian S, Young A, et al
    Anatomical-electrical coupling of cardiac axes: Definitions and population variability for advancing personalised ECG interpretation.
    PLoS Comput Biol. 2025;21:e1013161.
    PubMed     Abstract available


  25. KAY K, Prince JS, Gebhart T, Tuckute G, et al
    Disentangling signal and noise in neural responses through generative modeling.
    PLoS Comput Biol. 2025;21:e1012092.
    PubMed     Abstract available


  26. XIAO J, Yin Q, Li L, Meng Y, et al
    Tracking causal pathways in TMS-evoked brain responses.
    PLoS Comput Biol. 2025;21:e1013316.
    PubMed     Abstract available


  27. THEIS S, Mendieta-Serrano MA, Chapa-Y-Lazo B, Chen J, et al
    CellMet: Extracting 3D shape and topology metrics from confluent cells within tissues.
    PLoS Comput Biol. 2025;21:e1013260.
    PubMed     Abstract available


    June 2025
  28. STIKVOORT W, Perez-Ordoyo E, Mindlin I, Escrichs A, et al
    Nonequilibrium brain dynamics elicited as the origin of perturbative complexity.
    PLoS Comput Biol. 2025;21:e1013150.
    PubMed     Abstract available


  29. BAKER MR, Klassen BT, Jensen MA, Ojeda Valencia G, et al
    Parameterization of intraoperative human microelectrode recordings: Linking action potential morphology to brain anatomy.
    PLoS Comput Biol. 2025;21:e1013184.
    PubMed     Abstract available


  30. KANDASAMY A, Yeh YT, Serrano R, Mercola M, et al
    Uncertainty-aware traction force microscopy.
    PLoS Comput Biol. 2025;21:e1013079.
    PubMed     Abstract available


    May 2025
  31. BOTVINIK-NEZER R, Geuter S, Lindquist MA, Wager TD, et al
    Expectation generation and its effect on subsequent pain and visual perception.
    PLoS Comput Biol. 2025;21:e1013053.
    PubMed     Abstract available


  32. O'CONNOR OM, Dunlop MJ
    Cell-TRACTR: A transformer-based model for end-to-end segmentation and tracking of cells.
    PLoS Comput Biol. 2025;21:e1013071.
    PubMed     Abstract available


  33. VILLANUEVA-BAXARIAS I, Pellise-Tintore A, Perez-Rodriguez M, Nogue L, et al
    Understanding the hemodynamic changes in fetuses with coarctation of the aorta using a lumped model of fetal circulation.
    PLoS Comput Biol. 2025;21:e1013096.
    PubMed     Abstract available


  34. ZHAN Y, Musella F, Alber F
    MaxComp: Predicting single-cell chromatin compartments from 3D chromosome structures.
    PLoS Comput Biol. 2025;21:e1013114.
    PubMed     Abstract available


  35. YAMANE Y, Li Y, Matsumoto K, Kanai R, et al
    Optical Neuroimage Studio (OptiNiSt): Intuitive, scalable, extendable framework for optical neuroimage data analysis.
    PLoS Comput Biol. 2025;21:e1013087.
    PubMed     Abstract available


  36. SCHNITZERLEIN M, Greto E, Wegner A, Moller A, et al
    Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo.
    PLoS Comput Biol. 2025;21:e1011859.
    PubMed     Abstract available


    April 2025
  37. HICKL V, Khan A, Rossi RM, Silva BFB, et al
    Segmentation of dense and multi-species bacterial colonies using models trained on synthetic microscopy images.
    PLoS Comput Biol. 2025;21:e1012874.
    PubMed     Abstract available


  38. BARJUAN L, Zheng M, Serrano MA
    The multiscale self-similarity of the weighted human brain connectome.
    PLoS Comput Biol. 2025;21:e1012848.
    PubMed     Abstract available


  39. LEIBOVICH N, Goyal S
    Limitations and optimizations of cellular lineages tracking.
    PLoS Comput Biol. 2025;21:e1012880.
    PubMed     Abstract available


  40. GRABOT L, Merholz G, Winawer J, Heeger DJ, et al
    Traveling waves in the human visual cortex: An MEG-EEG model-based approach.
    PLoS Comput Biol. 2025;21:e1013007.
    PubMed     Abstract available


  41. VRIENS T, Vassena E, Pezzulo G, Baldassarre G, et al
    Meta-Reinforcement Learning reconciles surprise, value, and control in the anterior cingulate cortex.
    PLoS Comput Biol. 2025;21:e1013025.
    PubMed     Abstract available


  42. KE J, Song H, Bai Z, Rosenberg MD, et al
    Dynamic brain connectivity predicts emotional arousal during naturalistic movie-watching.
    PLoS Comput Biol. 2025;21:e1012994.
    PubMed     Abstract available


    March 2025
  43. ALTERIIS G, Sherwood O, Ciaramella A, Leech R, et al
    DySCo: A general framework for dynamic functional connectivity.
    PLoS Comput Biol. 2025;21:e1012795.
    PubMed     Abstract available


  44. SIGALAS E, Libedinsky C
    Mixed recurrent connectivity in primate prefrontal cortex.
    PLoS Comput Biol. 2025;21:e1012867.
    PubMed     Abstract available


  45. WANG Z, Yang Y, Huang Z, Zhao W, et al
    Exploring the transmission of cognitive task information through optimal brain pathways.
    PLoS Comput Biol. 2025;21:e1012870.
    PubMed     Abstract available


  46. DINNAGE R, Kleineberg M
    Generative AI extracts ecological meaning from the complex three dimensional shapes of bird bills.
    PLoS Comput Biol. 2025;21:e1012887.
    PubMed     Abstract available


  47. WANG T, Quast C, Bonner F, Kelm M, et al
    Investigation of hemodynamic bulk flow patterns caused by aortic stenosis using a combined 4D Flow MRI-CFD framework.
    PLoS Comput Biol. 2025;21:e1012467.
    PubMed     Abstract available


    January 2025
  48. BEN MESSAOUD R, Le Du V, Bousfiha C, Corsi MC, et al
    Low-dimensional controllability of brain networks.
    PLoS Comput Biol. 2025;21:e1012691.
    PubMed     Abstract available


  49. BADROU A, Mariano CA, Ramirez GO, Shankel M, et al
    Towards constructing a generalized structural 3D breathing human lung model based on experimental volumes, pressures, and strains.
    PLoS Comput Biol. 2025;21:e1012680.
    PubMed     Abstract available


  50. REN P, Cui X, Liang X
    Connectome-based biophysical models of pathological protein spreading in neurodegenerative diseases.
    PLoS Comput Biol. 2025;21:e1012743.
    PubMed     Abstract available


  51. GROS O, Passmore JB, Borst NO, Kutra D, et al
    Spherical harmonics texture extraction for versatile analysis of biological objects.
    PLoS Comput Biol. 2025;21:e1012349.
    PubMed     Abstract available


    December 2024
  52. FORRESTER M, Petros S, Cattell O, Lai YM, et al
    Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses.
    PLoS Comput Biol. 2024;20:e1012647.
    PubMed     Abstract available


  53. VANSLAMBROUCK M, Thiels W, Vangheel J, van Bavel C, et al
    Image-based force inference by biomechanical simulation.
    PLoS Comput Biol. 2024;20:e1012629.
    PubMed     Abstract available


  54. YUAN M, Goovaerts S, Vanneste M, Matthews H, et al
    Mapping genes for human face shape: Exploration of univariate phenotyping strategies.
    PLoS Comput Biol. 2024;20:e1012617.
    PubMed     Abstract available


  55. STASINSKI J, Taher H, Meier JM, Schirner M, et al
    Homeodynamic feedback inhibition control in whole-brain simulations.
    PLoS Comput Biol. 2024;20:e1012595.
    PubMed     Abstract available


  56. CELIKER E, Woodrow C, Guadayol O, Davranoglou LR, et al
    Mechanical network equivalence between the katydid and mammalian inner ears.
    PLoS Comput Biol. 2024;20:e1012641.
    PubMed     Abstract available


  57. KANG J, Park HJ
    Integration of partially observed multimodal and multiscale neural signals for estimating a neural circuit using dynamic causal modeling.
    PLoS Comput Biol. 2024;20:e1012655.
    PubMed     Abstract available


  58. BRYANT AG, Aquino K, Parkes L, Fornito A, et al
    Extracting interpretable signatures of whole-brain dynamics through systematic comparison.
    PLoS Comput Biol. 2024;20:e1012692.
    PubMed     Abstract available


    October 2024
  59. CHEN L, Huang ZH, Sun Y, Domaratzki M, et al
    Conditional probabilistic diffusion model driven synthetic radiogenomic applications in breast cancer.
    PLoS Comput Biol. 2024;20:e1012490.
    PubMed     Abstract available


  60. ISHAR J, Tam YM, Mages S, Klughammer J, et al
    BoReMi: Bokeh-based jupyter-interface for registering spatio-molecular data to related microscopy images.
    PLoS Comput Biol. 2024;20:e1012504.
    PubMed     Abstract available


  61. RANJAN A, Swain JK, Ahluwalia BS, Melandso F, et al
    3-D Visualization of Atlantic salmon skin through Ultrasound and Photoacoustic Microscopy.
    PLoS Comput Biol. 2024;20:e1011709.
    PubMed     Abstract available


  62. YU S, Wu J, Shao Y, Qiu D, et al
    A novel classification framework for genome-wide association study of whole brain MRI images using deep learning.
    PLoS Comput Biol. 2024;20:e1012527.
    PubMed     Abstract available


  63. COCUZZA CV, Sanchez-Romero R, Ito T, Mill RD, et al
    Distributed network flows generate localized category selectivity in human visual cortex.
    PLoS Comput Biol. 2024;20:e1012507.
    PubMed     Abstract available


    September 2024
  64. FRANCO JP, Bossaerts P, Murawski C
    The neural dynamics associated with computational complexity.
    PLoS Comput Biol. 2024;20:e1012447.
    PubMed     Abstract available


    August 2024
  65. RAMOS JDS, Vieira IHP, Rocha WS, Esquerdo RP, et al
    A transfer learning approach to identify Plasmodium in microscopic images.
    PLoS Comput Biol. 2024;20:e1012327.
    PubMed     Abstract available


  66. GUNNARSSON EB, Kim S, Choi B, Schmid JK, et al
    Understanding patient-derived tumor organoid growth through an integrated imaging and mathematical modeling framework.
    PLoS Comput Biol. 2024;20:e1012256.
    PubMed     Abstract available


  67. DEAN WF, Nawara TJ, Albert RM, Mattheyses AL, et al
    OOPS: Object-Oriented Polarization Software for analysis of fluorescence polarization microscopy images.
    PLoS Comput Biol. 2024;20:e1011723.
    PubMed     Abstract available


  68. MAHJOORY K, Bahmer A, Henry MJ
    Convolutional neural networks can identify brain interactions involved in decoding spatial auditory attention.
    PLoS Comput Biol. 2024;20:e1012376.
    PubMed     Abstract available


  69. SEELER D, Grdseloff N, Rodel CJ, Kloft C, et al
    Novel mathematical approach to accurately quantify 3D endothelial cell morphology and vessel geometry based on fluorescently marked endothelial cell contours: Application to the dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos.
    PLoS Comput Biol. 2024;20:e1011924.
    PubMed     Abstract available


    July 2024
  70. CHEN AA, Clark K, Dewey BE, DuVal A, et al
    PARE: A framework for removal of confounding effects from any distance-based dimension reduction method.
    PLoS Comput Biol. 2024;20:e1012241.
    PubMed     Abstract available


    June 2024
  71. SANDA P, Hlinka J, van den Berg M, Skoch A, et al
    Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression.
    PLoS Comput Biol. 2024;20:e1012099.
    PubMed     Abstract available


  72. YAO T, Pajaziti E, Quail M, Schievano S, et al
    Image2Flow: A proof-of-concept hybrid image and graph convolutional neural network for rapid patient-specific pulmonary artery segmentation and CFD flow field calculation from 3D cardiac MRI data.
    PLoS Comput Biol. 2024;20:e1012231.
    PubMed     Abstract available


    May 2024
  73. DAGNINO PC, Escrichs A, Lopez-Gonzalez A, Gosseries O, et al
    Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation.
    PLoS Comput Biol. 2024;20:e1011350.
    PubMed     Abstract available


  74. CHUNG MK, Huang SG, Carroll IC, Calhoun VD, et al
    Topological state-space estimation of functional human brain networks.
    PLoS Comput Biol. 2024;20:e1011869.
    PubMed     Abstract available


  75. RYU J, Nejatbakhsh A, Torkashvand M, Gangadharan S, et al
    Versatile multiple object tracking in sparse 2D/3D videos via deformable image registration.
    PLoS Comput Biol. 2024;20:e1012075.
    PubMed     Abstract available


  76. CONTE M, Woodall RT, Gutova M, Chen BT, et al
    Structural and practical identifiability of contrast transport models for DCE-MRI.
    PLoS Comput Biol. 2024;20:e1012106.
    PubMed     Abstract available


    March 2024
  77. TOYOSHIMA Y, Sato H, Nagata D, Kanamori M, et al
    Ensemble dynamics and information flow deduction from whole-brain imaging data.
    PLoS Comput Biol. 2024;20:e1011848.
    PubMed     Abstract available


  78. LIU P, Bo K, Ding M, Fang R, et al
    Emergence of Emotion Selectivity in Deep Neural Networks Trained to Recognize Visual Objects.
    PLoS Comput Biol. 2024;20:e1011943.
    PubMed     Abstract available


  79. WANG HT, Meisler SL, Sharmarke H, Clarke N, et al
    Continuous evaluation of denoising strategies in resting-state fMRI connectivity using fMRIPrep and Nilearn.
    PLoS Comput Biol. 2024;20:e1011942.
    PubMed     Abstract available


    February 2024
  80. CHEN LD, Caprio MA, Chen DM, Kouba AJ, et al
    Enhancing predictive performance for spectroscopic studies in wildlife science through a multi-model approach: A case study for species classification of live amphibians.
    PLoS Comput Biol. 2024;20:e1011876.
    PubMed     Abstract available


  81. ESCHWEILER D, Yilmaz R, Baumann M, Laube I, et al
    Denoising diffusion probabilistic models for generation of realistic fully-annotated microscopy image datasets.
    PLoS Comput Biol. 2024;20:e1011890.
    PubMed     Abstract available


  82. SOULOS P, Isik L
    Disentangled deep generative models reveal coding principles of the human face processing network.
    PLoS Comput Biol. 2024;20:e1011887.
    PubMed     Abstract available


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