: The AMEDEO Literature Guide

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Drug Resistance

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Articles published in Antimicrob Agents Chemother
Retrieve available abstracts of 386 articles:
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Single Articles

August 2026

HU E-W, Kuo P-C, Li L-H, Yen C-S, et al
NagX, a periplasmic beta-N-acetylglucosaminidase, contributes to NagZ-independent beta-lactamase expression in Stenotrophomonas maltophilia.
Antimicrob Agents Chemother. 2026;70:e0024326.
PubMed Abstract available

HERNANDEZ-GARCIA M, Perez-Viso B, Nieto-Torres M, Garcia-Castillo M, et al
Addressing therapeutic options for KPC-3-producing ST307-Klebsiella pneumoniae: insights from in vitro evolution and mutant prevention strategies.
Antimicrob Agents Chemother. 2026;70:e0048826.
PubMed Abstract available

MAEDA A, Sato T, Fukuda A, Okubo T, et al
A community-based One Health approach to the pandemic dynamics of Escherichia coli ST131.
Antimicrob Agents Chemother. 2026;70:e0000726.
PubMed Abstract available

SCHUMANN A, O'Keefe IP, Ernst RK, Wiedmann M, et al
Acquired mutations in transcriptional regulator hns and lipopolysaccharide biosynthesis and modification genes impact colistin resistance and fitness of mcr-carrying E. coli.
Antimicrob Agents Chemother. 2026;70:e0045726.
PubMed Abstract available

CORRAL J, Perez-Varela M, Gaona M, Campoy S, et al
A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2026;70:e0164425.
PubMed Abstract available

ROME KJ, Terlecky AJ, Yen KK, Long T, et al
Intrinsic resistance networks shape cefiderocol susceptibility in ST258 Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2026;70:e0019726.
PubMed Abstract available

SASTRE-FEMENIA MA, Gomis-Font MA, Fernandez-Munoz A, Salazar-Londono D, et al
Characterizing the V516M penicillin-binding protein 2 (PBP2) mutation causing zidebactam resistance in Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2026;70:e0034626.
PubMed Abstract available

FERNANDEZ MA, Gomez Gomez MJ, Cisneros JM, Lepe JA, et al
Characterization of BAS-1, a novel class A beta-lactamase encoded in Bacteroides thetaiotaomicron.
Antimicrob Agents Chemother. 2026;70:e0039126.
PubMed Abstract available

KAPLE CE, Redmond SN, Cadnum JL, Hausman B, et al
Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a Clostridioides difficile isolate with reduced fidaxomicin susceptibility in an elderly man.
Antimicrob Agents Chemother. 2026;70:e0013026.
PubMed Abstract available

ZHU Z, Long T, Wang B, Ding W, et al
Genome-wide transposon screening uncovers phage resistance mechanisms and bidirectional effects on antibiotic susceptibility in carbapenem-resistant Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2026 Aug 5:e0050626. doi: 10.1128/aac.00506.
PubMed Abstract available

CHENG S, Clancy CJ, Fleres G, Badrane H, et al
Emergence of mutH(V76G) in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype.
Antimicrob Agents Chemother. 2026 Aug 5:e0018926. doi: 10.1128/aac.00189.
PubMed Abstract available

XIE O, Tan A, Nguyen TB, Hayes AJ, et al
Penicillin-resistant Streptococcus dysgalactiae subsp. equisimilis and the association with penicillin-binding protein mutations: a population genotypic and phenotypic study.
Antimicrob Agents Chemother. 2026 Aug 3:e0013726. doi: 10.1128/aac.00137.
PubMed Abstract available

July 2026

WU R, Kaur S, Payne M, Zhang L, et al
Multilevel HierCC typing scheme for global genomic epidemiology and antimicrobial resistance surveillance of Campylobacter jejuni.
Antimicrob Agents Chemother. 2026 Jul 28:e0031026. doi: 10.1128/aac.00310.
PubMed Abstract available

BAJPAI S, Sultany A, Carroll K, Zain R, et al
Selective digestive decontamination and antimicrobial resistance: defining thresholds before global implementation.
Antimicrob Agents Chemother. 2026 Jul 21:e0068126. doi: 10.1128/aac.00681.
PubMed

CORNISTEIN W, Staneloni MI
Reply to Bajpai et al., "Selective digestive decontamination and antimicrobial resistance: defining thresholds before global implementation".
Antimicrob Agents Chemother. 2026 Jul 21:e0071226. doi: 10.1128/aac.00712.
PubMed

HOME JL, Yeoh LM, McFadden GI, Goodman CD, et al
Mutations in apicoplast rRNA genes are associated with clindamycin resistance and impair the ability of malaria parasites to infect mosquitoes.
Antimicrob Agents Chemother. 2026 Jul 15:e0050726. doi: 10.1128/aac.00507.
PubMed Abstract available

CHIU P-W, Wang J-L, Hsueh S-C, Lee N-Y, et al
Cefiderocol nonsusceptibility among carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: data from the 2024 Antimicrobial Testing Leadership and Surveillance (ATLAS) program.
Antimicrob Agents Chemother. 2026 Jul 13:e0063426. doi: 10.1128/aac.00634.
PubMed Abstract available

KAPOOR A, Ghosh AK, Forman M, Skaist A, et al
A novel inhibitor of human cytomegalovirus acts through a specific antiviral mechanism that involves the helicase-primase complex.
Antimicrob Agents Chemother. 2026 Jul 13:e0197725. doi: 10.1128/aac.01977.
PubMed Abstract available

LIU H, Huang X, Li X, Li Y, et al
A genomic framework for tracking antibiotic resistance genes: global dissemination of cfr-family genes.
Antimicrob Agents Chemother. 2026 Jul 10:e0012226. doi: 10.1128/aac.00122.
PubMed Abstract available

MALLECOT E, Berti V, Petitjean M, Meyer J, et al
Influence of iron uptake systems on cefiderocol activity in Escherichia coli: At the crossroads of antibiotic resistance and virulence.
Antimicrob Agents Chemother. 2026 Jul 10:e0167925. doi: 10.1128/aac.01679.
PubMed Abstract available

PETERSIEL N, Howden BP, Giulieri S, Tong SYC, et al
An Achilles' heel for methicillin-resistant Staphylococcus aureus? Re-evaluating beta-lactam susceptibility of MRSA.
Antimicrob Agents Chemother. 2026 Jul 6:e0037426. doi: 10.1128/aac.00374.
PubMed Abstract available

HUANG Y-T, Kao C-Y, Kuo H-Y, Kao L-T, et al
Molecular epidemiology and emerging tet(X)-associated resistance of Elizabethkingia spp. in Taiwan, 2016-2022.
Antimicrob Agents Chemother. 2026;70:e0038726.
PubMed Abstract available

LASS-FLORL C, Steixner S, Bauer A, Meis JF, et al
Why intrinsic reduced susceptibility in rare fungal pathogens should be differentiated from intrinsic resistance: an ISHAM conceptual framework and narrative review.
Antimicrob Agents Chemother. 2026;70:e0026326.
PubMed Abstract available

LAMOTH F
New Perspectives on Antimicrobial Agents: Fosmanogepix.
Antimicrob Agents Chemother. 2026;70:e0032426.
PubMed Abstract available

XU J, Fu P, Xu H-M, Jing C-M, et al
Pediatric candidemia epidemiology and antifungal susceptibility profiles reported by the ISPED program in China, 2016-2024.
Antimicrob Agents Chemother. 2026;70:e0003126.
PubMed Abstract available

GAGLANI B, Andermann TM, Wate C, Oldan J, et al
Sulbactam-durlobactam and cefiderocol combination treatment of Burkholderia cenocepacia-associated Fitz-Hugh-Curtis syndrome.
Antimicrob Agents Chemother. 2026;70:e0154225.
PubMed Abstract available

June 2026

TERLECKY AJ, Thom KV, Kan VW, Jiang J, et al
Genomic diversity and topical antimicrobial resistance in Staphylococcus aureus from clinical and carriage populations in the New York-New Jersey region.
Antimicrob Agents Chemother. 2026 Jun 30:e0065426. doi: 10.1128/aac.00654.
PubMed Abstract available

HUA M, Wei H, Jiang Y, Gu C, et al
A monoclonal antibody targeting OXA23 restores carbapenem susceptibility in global epidemic carbapenem-resistant Acinetobacter baumannii.
Antimicrob Agents Chemother. 2026 Jun 25:e0179625. doi: 10.1128/aac.01796.
PubMed Abstract available

DE VOS MGJ, Jansen V, El Bouhlali O, Vlasblom AA, et al
Pyocyanin produced by Pseudomonas aeruginosa creates legacy effects that promote antibiotic resistance evolution in enterococci.
Antimicrob Agents Chemother. 2026 Jun 22:e0007826. doi: 10.1128/aac.00078.
PubMed Abstract available

DYCK KV, Hoogenkamp MA, Eichenseher F, Van Dijck P, et al
Phage-derived endolysin prevents dissemination of methicillin resistant Staphylococcus aureus during oral co-infection with Candida albicans.
Antimicrob Agents Chemother. 2026 Jun 15:e0181225. doi: 10.1128/aac.01812.
PubMed Abstract available

COLLAR GDS, Dornelles LS, Salvador JC, Pinto JB, et al
Consistent in vitro activity of sulbactam-durlobactam against genetically diverse carbapenem-resistant Acinetobacter baumannii in a high-endemic Brazilian setting.
Antimicrob Agents Chemother. 2026 Jun 12:e0010926. doi: 10.1128/aac.00109.
PubMed Abstract available

MIYASHITA N, Ogata M, Fukuda N, Yamura A, et al
Efficacy of garenoxacin in patients with macrolide-resistant Mycoplasma pneumoniae pneumonia.
Antimicrob Agents Chemother. 2026 Jun 11:e0002526. doi: 10.1128/aac.00025.
PubMed Abstract available

NOLAN AC, Kelly JB, Ahn J, Shinde D, et al
The beta-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2026 Jun 10:e0037726. doi: 10.1128/aac.00377.
PubMed Abstract available

SUN W, Tian M, Wang X, Jiang S, et al
The protective effect of Schisandrin C against methicillin-resistant Staphylococcus aureus-induced otitis media.
Antimicrob Agents Chemother. 2026 Jun 10:e0009526. doi: 10.1128/aac.00095.
PubMed Abstract available

CHARPENTIER C, Montrouge T, Wirden M, Avettand-Fenoel V, et al
A French national observatory of people with HIV initiating lenacapavir-based treatment after regulatory approval.
Antimicrob Agents Chemother. 2026 Jun 10:e0022826. doi: 10.1128/aac.00228.
PubMed Abstract available

WIEDERHOLD NP, Patterson HP, Sanders C, Canete-Gibas C, et al
Manogepix demonstrates potent in vitro activity against Aspergillus, Coccidioides, Scopulariopsis/Microascus, Rasamsonia, and Purpureocillium species, including strains with in vitro resistance to other antifungals.
Antimicrob Agents Chemother. 2026 Jun 4:e0047626. doi: 10.1128/aac.00476.
PubMed Abstract available

KUNZ COYNE AJ, Judd C, Lucas K, Al Musawa M, et al
Ceftazidime-avibactam for multidrug-resistant gram-negative infections: outcomes and timing of initiation across 22 U.S. medical centers.
Antimicrob Agents Chemother. 2026;70:e0026826.
PubMed Abstract available

WANG Y, Wang Y, Zhai W, Chen W, et al
Emergence of tet(X4)-positive Klebsiella isolates from aquatic products in Hainan, China.
Antimicrob Agents Chemother. 2026;70:e0161825.
PubMed Abstract available

WALKER MM, Roberts JA, Li Y, Naicker S, et al
Evaluating the efficacy of ceftazidime/avibactam plus amikacin combination therapy as a carbapenem-sparing agent against ceftazidime/avibactam-resistant Escherichia coli using a hollow fiber infection model: a proof-of-concept study.
Antimicrob Agents Chemother. 2026;70:e0137725.
PubMed Abstract available

LIU Y, Hong H, Huang Q, Fan L, et al
Characterization of KPC-160, a novel Omega-loop-deleted KPC variant on a dual-copy plasmid that confers cefiderocol resistance.
Antimicrob Agents Chemother. 2026;70:e0135825.
PubMed Abstract available

MORGAN GM, Kimbrough JH, Karr MH, Thompson J, et al
Determination of frequency of spontaneous resistance for gepotidacin and levofloxacin against a collection of gram-positive and gram-negative organisms.
Antimicrob Agents Chemother. 2026;70:e0183225.
PubMed Abstract available

YI Q-L, Xu K-W, Guo P-H, Li L, et al
Surveillance for invasive candidiasis in China (CHIF-NET 2018-2021): rising antifungal resistance observed in a nationwide longitudinal study.
Antimicrob Agents Chemother. 2026;70:e0003526.
PubMed Abstract available

WU M, Chen Y, Su M, Wu H, et al
Domestic travel as a driver for the dissemination of mcr-1 in healthy travelers in China: a prospective, genomic epidemiological and gut microbiome study.
Antimicrob Agents Chemother. 2026;70:e0174625.
PubMed Abstract available

May 2026

DEKA N, Brauer AL, Connerton K, Hanson BM, et al
Pangenome analysis of Proteus mirabilis reveals lineage-specific antimicrobial resistance profiles and discordant genotype-phenotype correlations.
Antimicrob Agents Chemother. 2026 May 29:e0176825. doi: 10.1128/aac.01768.
PubMed Abstract available

GONZALEZ-PINTO L, Monge-Olivares L, Perez-Rodriguez G, Aja-Macaya P, et al
Genetic and biochemical characterization of OXA-1054, a carbapenem-hydrolyzing class D beta-lactamase conferring broad-spectrum beta-lactam resistance in Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2026 May 29:e0180525. doi: 10.1128/aac.01805.
PubMed Abstract available

AMUSIN DB, Simons LM, Garcia DS, Gatesy SWM, et al
Identification of Streptococcus pyogenes isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis.
Antimicrob Agents Chemother. 2026 May 29:e0035426. doi: 10.1128/aac.00354.
PubMed Abstract available

GOTTESDIENER LS, Li Y, Greenwood-Quaintance KE, Komarow L, et al
Resistance to novel beta-lactam/beta-lactamase inhibitors among carbapenem-resistant Pseudomonas aeruginosa and clinical implications in the prospective observational Pseudomonas study.
Antimicrob Agents Chemother. 2026 May 15:e0038825. doi: 10.1128/aac.00388.
PubMed Abstract available

VAHEDI-SHAHANDASHTI R, Nickel A-S, Eisele D, Lass-Florl C, et al
Can voriconazole gradient diffusion testing results be extrapolated to isavuconazole and posaconazole in Aspergillus spp.? Comparative analysis with CLSI broth microdilution and cyp51A gene sequencing.
Antimicrob Agents Chemother. 2026 May 15:e0181325. doi: 10.1128/aac.01813.
PubMed Abstract available

CAI G, Zhang Z
Global surveillance of Candida albicans: MIC distributions, resistance patterns, and temporal trends from the Antimicrobial Testing Leadership and Surveillance program (2015-2024).
Antimicrob Agents Chemother. 2026 May 12:e0161725. doi: 10.1128/aac.01617.
PubMed Abstract available

LU W, Li L, Lin X, Liu D, et al
Identification and characteristics of a novel fosfomycin glutathione transferase, FosA12, from an MDR clinical isolate of Proteus vulgaris.
Antimicrob Agents Chemother. 2026;70:e0113825.
PubMed Abstract available

DORAZIO AJ, Kline EG, Squires KM, Shah S, et al
Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel beta-lactams.
Antimicrob Agents Chemother. 2026;70:e0191025.
PubMed Abstract available

STELLFOX ME, Doi Y
Case Commentary: When one target is not enough-PBP3 insertions and target redundancy in Escherichia coli.
Antimicrob Agents Chemother. 2026;70:e0005326.
PubMed Abstract available

DOS SANTOS AR, Bonifaz A, Bombassaro A, Machado ACdS, et al
Establishment of epidemiological cutoff values for clinically relevant Sporothrix species using CLSI-broth microdilution.
Antimicrob Agents Chemother. 2026;70:e0190725.
PubMed Abstract available

YAMADA T, Maeda M, Nakagawa M, Yaguchi T, et al
The entire CYP51B locus in azole-resistant isolates of the dermatophyte Trichophyton indotineae revealed by optical genome mapping.
Antimicrob Agents Chemother. 2026;70:e0181725.
PubMed Abstract available

LE ROY C, Guiraud J, Byambaa O, Balcon C, et al
In vitro selection and characterization of resistance to pristinamycin in Mycoplasma genitalium.
Antimicrob Agents Chemother. 2026;70:e0009426.
PubMed Abstract available

PEREZ-RODRIGUEZ G, Aja-Macaya P, Gonzalez-Pinto L, Taltavull B, et al
Emergence of KPC-producing Pseudomonas aeruginosa in Spain: insights into an outbreak and resistance to the novel carbapenem/beta-lactamase inhibitor combinations imipenem/relebactam and meropenem/vaborbactam.
Antimicrob Agents Chemother. 2026;70:e0165725.
PubMed Abstract available

ZHOU M, Yang Z, Wang M, Jia R, et al
Identification and characteristics of a novel acquired aminoglycoside phosphotransferase, APH(3')-IVb, from Riemerella anatipestifer.
Antimicrob Agents Chemother. 2026;70:e0163125.
PubMed Abstract available

KUNZ COYNE AJ, Gray R, Gonnabathula P, May ES, et al
Comparative in vitro activity of aztreonam-avibactam and aztreonam plus ceftazidime-avibactam against Stenotrophomonas maltophilia complex.
Antimicrob Agents Chemother. 2026;70:e0145625.
PubMed Abstract available

VOLYNKINA IA, Bortyazh MO, Chen C-W, Tereshchenkov AG, et al
Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression.
Antimicrob Agents Chemother. 2026;70:e0153925.
PubMed Abstract available

ROYER G, Danjean M, Rodriguez C, Fihman V, et al
Piperacillin-tazobactam resistance in Klebsiella pneumoniae is often associated with IS26-mediated bla(SHV-1) amplification in a widespread Klebsiella-adapted plasmid.
Antimicrob Agents Chemother. 2026;70:e0168225.
PubMed Abstract available

SHROPSHIRE WC, Borjan J, Fonseca IY, Pham K, et al
Clinical and genomic determinants associated with emergent ceftazidime-avibactam plus aztreonam non-susceptibility in ceftazidime-avibactam resistant Escherichia coli.
Antimicrob Agents Chemother. 2026;70:e0186025.
PubMed Abstract available

FABRIZIO C, Valzano F, Giuliano S, Morelli E, et al
Optimizing target inactivation to treat multidrug-resistant Escherichia coli with NDM and PBP3 mutations: "going the extra mile".
Antimicrob Agents Chemother. 2026;70:e0088725.
PubMed Abstract available

April 2026

ZHU J, Wang Y, Mei C, Weng Y, et al
OmpK36 GD insertion induces RpoS-dependent bla(KPC) overexpression in carbapenem-resistant Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2026 Apr 20:e0182425. doi: 10.1128/aac.01824.
PubMed Abstract available

YANG Z, Zhang Y, Li D, Wang S, et al
Drug-resistant clinical Candida responded to 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in vitro via enhanced ROS release.
Antimicrob Agents Chemother. 2026 Apr 17:e0164525. doi: 10.1128/aac.01645.
PubMed Abstract available

GARCIA-RIVERA C, Roda-Garcia JJ, Rodriguez JC, Molina-Pardines C, et al
Bridging clinical and environmental reservoirs: antimicrobial resistance in the emerging pathogen Shewanella algae.
Antimicrob Agents Chemother. 2026 Apr 15:e0189125. doi: 10.1128/aac.01891.
PubMed Abstract available

LOPEZ-CAUSAPE C, Bonet M, Taltavull B, Medina-Retiga P, et al
PaREx: an open-source pipeline for the automated analysis of Pseudomonas aeruginosa resistomes from whole-genome sequences.
Antimicrob Agents Chemother. 2026;70:e0132625.
PubMed Abstract available

BAILEY DC, Castaneda-Barba S, Barry KE, Treerat P, et al
In vivo evolution of resistance to contemporary beta-lactam/beta-lactamase inhibitor combinations during treatment of a KPC-producing Serratia marcescens infection.
Antimicrob Agents Chemother. 2026;70:e0165125.
PubMed Abstract available

SHEN C, Wang L, Zhang Y, Zhang L, et al
Pseudomonas aeruginosa tRNA nucleotidyltransferase Cca controls resistance and tolerance to aminoglycoside antibiotics by regulating the MexXY multidrug efflux pump.
Antimicrob Agents Chemother. 2026;70:e0165325.
PubMed Abstract available

FUNCK T, McGowen K, Sullivan MR, Zinga S, et al
Ribosomal protection as a linezolid resistance mechanism in Mycobacterium abscessus.
Antimicrob Agents Chemother. 2026;70:e0160525.
PubMed Abstract available

JEAN-PIERRE V, Moulieras M, Pantel A, Aujoulat F, et al
Molecular basis of linezolid resistance in Finegoldia spp. from orthopedic infections.
Antimicrob Agents Chemother. 2026;70:e0170225.
PubMed Abstract available

HONG Y-P, Liao Y-S, Chen B-H, Wang Y-W, et al
Epidemiology and genomics of azithromycin-resistant extensively drug-resistant Salmonella enterica serovar Typhimurium in Taiwan.
Antimicrob Agents Chemother. 2026;70:e0133425.
PubMed Abstract available

March 2026

XI B, Wu Y
Peroxin Pex8 couples stress responses, antifungal tolerance, and virulence regulation in Candida albicans.
Antimicrob Agents Chemother. 2026 Mar 24:e0166225. doi: 10.1128/aac.01662.
PubMed Abstract available

KRANKEL L, Hauser J, Slavetinsky J, Zinser A, et al
Polygenic, cell-envelope adaptations drive high-frequency daptomycin resistance in Staphylococcus capitis NRCS-A from neonatal sepsis and NEC.
Antimicrob Agents Chemother. 2026 Mar 24:e0141425. doi: 10.1128/aac.01414.
PubMed Abstract available

SANCHEZ-OSUNA M, Bierge P, Gomez-Sanchez I, Guitart-Matas J, et al
Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate.
Antimicrob Agents Chemother. 2026 Mar 23:e0194825. doi: 10.1128/aac.01948.
PubMed Abstract available

ARASTEHFAR A, Daneshnia F, Hovhannisyan H, Cabrera N, et al
Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization.
Antimicrob Agents Chemother. 2026 Mar 23:e0180125. doi: 10.1128/aac.01801.
PubMed Abstract available

SANTANA DJ, Cauldron NC, Rogers PD, Cuomo CA, et al
Deciphering the multidrug resistance paradigm in Candida auris.
Antimicrob Agents Chemother. 2026 Mar 16:e0106224. doi: 10.1128/aac.01062.
PubMed Abstract available

YAO L, Tian T, Zou D, Lu X, et al
Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae.
Antimicrob Agents Chemother. 2026 Mar 11:e0170625. doi: 10.1128/aac.01706.
PubMed Abstract available

JOUSSET AB, Girlich D, Oueslati S, Birer A, et al
In vivo selection of CMY-219 conferring resistance to ceftazidime-avibactam in an OXA-484-producing E. coli ST410.
Antimicrob Agents Chemother. 2026;70:e0133525.
PubMed Abstract available

LEHMAN D, Hetzler AE, Friedrich T, Strouse MM, et al
Variable chlorhexidine MICs across Klebsiella species from a single facility.
Antimicrob Agents Chemother. 2026;70:e0143625.
PubMed Abstract available

BAI Y-M, Gao X-J, Yue C, Cai Z-P, et al
Salmonella Stanley ST29 carrying IncHI2/ST3-bla(NDM-5) plasmid emerged in a 4-month-old infant with diarrhea.
Antimicrob Agents Chemother. 2026;70:e0147125.
PubMed Abstract available

ROYER M, Cabanel N, Gutierrez A, Royer G, et al
The mecillinam resistome in Klebsiella pneumoniae: how resistance to a one-target beta-lactam triggers a diversity of responses.
Antimicrob Agents Chemother. 2026;70:e0120725.
PubMed Abstract available

WANG J, Zhu J, Wu W, Luo R, et al
Clinical outcomes and safety of eravacycline in hematology: a multicenter, real-world study.
Antimicrob Agents Chemother. 2026;70:e0128725.
PubMed Abstract available

DING R, Ma K, Zhang K, Liu J, et al
Broxyquinoline enhances antibacterial activity of colistin and attenuates LPS-induced inflammation.
Antimicrob Agents Chemother. 2026;70:e0139825.
PubMed Abstract available

GONZALEZ-DIAZ A, Pinto M, Cadenas-Jimenez I, Duarte S, et al
First identification and molecular characterization of CTX-M-15 extended-spectrum beta-lactamase and OXA-9 beta-lactamase in Haemophilus influenzae in the Iberian Peninsula.
Antimicrob Agents Chemother. 2026;70:e0164925.
PubMed Abstract available

YANG X, Ning W, Yuan Y, Hou X, et al
Novel metabolic adaptation driven by glycoside hydrolase family 25 protein contributes to increasing trimethoprim-sulfamethoxazole resistance in clinical human Brucella melitensis isolates in China.
Antimicrob Agents Chemother. 2026;70:e0128425.
PubMed Abstract available

PONTIKIS K, Karaiskos I, Sakagianni A, Mouloudi E, et al
Comparative effectiveness of two antimicrobial regimens for the treatment of pan-drug-resistant Acinetobacter baumannii infections: results from the DESPAIR study.
Antimicrob Agents Chemother. 2026;70:e0115425.
PubMed Abstract available

HANDELMAN M, Sarkar A, Varshavsky A, Shadkchan Y, et al
Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel genes contributing to triazole resistance.
Antimicrob Agents Chemother. 2026 Mar 4:e0163525. doi: 10.1128/aac.01635.
PubMed Abstract available

YIN T, Qu B, Zhang Q, Xu S, et al
Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects.
Antimicrob Agents Chemother. 2026 Mar 3:e0069425. doi: 10.1128/aac.00694.
PubMed Abstract available

February 2026

CHEN J, Sun Z, Su J, Li P, et al
Functional characterization of a novel class A carbapenemase CAE-1 in carbapenem-resistant Pseudomonas aeruginosa clinical isolates.
Antimicrob Agents Chemother. 2026 Feb 23:e0136225. doi: 10.1128/aac.01362.
PubMed Abstract available

ZHANG R, Zhang C, Liu J, Kong X, et al
Therapeutic effect of eravacycline against carbapenem-resistant hypervirulent Klebsiella pneumoniae in mouse models.
Antimicrob Agents Chemother. 2026 Feb 23:e0123725. doi: 10.1128/aac.01237.
PubMed Abstract available

LI P, Xiao Y, Luo R, Zhang J, et al
Comparative genomic, phenotypic, and clinical characterization of ST11-KL25 and ST11-KL64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital, 2020-2023.
Antimicrob Agents Chemother. 2026 Feb 19:e0108025. doi: 10.1128/aac.01080.
PubMed Abstract available

WIEDERHOLD NP, Najvar LK, Jaramillo R, Olivo M, et al
The novel second-generation triterpenoid SCY-247 maintains in vitro and in vivo activity against resistant Candida glabrata.
Antimicrob Agents Chemother. 2026 Feb 19:e0162525. doi: 10.1128/aac.01625.
PubMed Abstract available

DELLIS C, Laros G, Georgiou K, Zhang L, et al
Iotadentification of SQ109 analogs with enhanced antimicrobial activity against methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2026 Feb 18:e0154525. doi: 10.1128/aac.01545.
PubMed Abstract available

LEE Y-L, Wang W-Y, Huang Y-T, Ho M-W, et al
In vitro activity of aztreonam-avibactam and distribution of carbapenemase genes in ceftazidime-avibactam-resistant carbapenem-resistant Enterobacterales: data from the global Antimicrobial Testing Leadership and Surveillance, 2019-2023.
Antimicrob Agents Chemother. 2026 Feb 18:e0154925. doi: 10.1128/aac.01549.
PubMed Abstract available

MA D, Arya R, Knapick BA, Sadaka NM, et al
Methicillin-resistant Staphylococcus aureus has phenotypic variation in mecA expression that alters antibiotic sensitivity.
Antimicrob Agents Chemother. 2026 Feb 12:e0039625. doi: 10.1128/aac.00396.
PubMed Abstract available

NISHIHARA Y, Nakano R, Nakano A, Suzuki Y, et al
Differences in beta-lactamase activity and carbapenem resistance among the Bacillus cereus group.
Antimicrob Agents Chemother. 2026 Feb 9:e0130225. doi: 10.1128/aac.01302.
PubMed Abstract available

ZHENG X, You X, Liu Y, Wu B, et al
Spatiotemporal dynamics and multiple driving factors of antimicrobial resistance in China during the COVID-19 pandemic (2019-2023): a provincial panel data analysis.
Antimicrob Agents Chemother. 2026 Feb 9:e0160025. doi: 10.1128/aac.01600.
PubMed Abstract available

COLLINGS H, Stone M, Chrysostomou M, Hirst A, et al
A systematic literature review and (network) meta-analysis of the effectiveness of ceftolozane/tazobactam versus aminoglycosides/polymyxins and ceftazidime/avibactam for treating adult patients with multidrug-resistant Pseudomonas aeruginosa infection
Antimicrob Agents Chemother. 2026;70:e0073525.
PubMed Abstract available

MOHAMMAD S, Al Namer Y, Rahimeh W, Albalas M, et al
Effectiveness and safety of meropenem-vaborbactam versus ceftazidime-avibactam in multidrug-resistant Gram-negative infections: a systematic review and meta-analysis with trial sequential analysis.
Antimicrob Agents Chemother. 2026;70:e0154625.
PubMed Abstract available

OMACHI R, Imai K, Sato A, Tanaka M, et al
Spread of dual-class drug-resistant Mycoplasma genitalium in Tokyo, Japan, 2023-2025.
Antimicrob Agents Chemother. 2026;70:e0136725.
PubMed Abstract available

FAN M, Zhang Z, Liu X, Deng L, et al
Phylogenetic diversification and fitness trade-offs of TetA variants in mediating eravacycline resistance in Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2026;70:e0067125.
PubMed Abstract available

FINGLETON C, Zeden MS, Bueno E, Cava F, et al
Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics.
Antimicrob Agents Chemother. 2026;70:e0127625.
PubMed Abstract available

LIU Y, Cui P, Sun J, Ru S, et al
A short antimicrobial peptides family demonstrates efficacy to infection via a multimodal mechanism of action.
Antimicrob Agents Chemother. 2026;70:e0134325.
PubMed Abstract available

TIREAU B, Hamane S, Weber S, Benderdouche M, et al
Comparison of gradient concentration strip and EUCAST methods for itraconazole and posaconazole MICs in Trichophyton indotineae.
Antimicrob Agents Chemother. 2026;70:e0129325.
PubMed Abstract available

BAEZ-BARROSO G-A, Rodriguez-Coello A, Vazquez-Ucha JC, Lopez-Arguello S, et al
Antibacterial activity of enmetazobactam against Acinetobacter spp.: a molecular dissection of mechanism of action and resistance determinants.
Antimicrob Agents Chemother. 2026;70:e0120625.
PubMed Abstract available

ALHOTHALI MT, Seemann T, Andersson P, Sherry N, et al
Rising burden of enterococcal bacteremia in Victoria, Australia: population-based incidence and antimicrobial resistance trends from three decades of surveillance.
Antimicrob Agents Chemother. 2026 Feb 4:e0152625. doi: 10.1128/aac.01526.
PubMed Abstract available

SONG Y, Buil JB, Zoll J, Tehupeiory-Kooreman M, et al
Characteristics of individual cyp51A SNPs and combinations thereof impacting the azole phenotype in TR(34)-mediated resistance genotypes of Aspergillus fumigatus.
Antimicrob Agents Chemother. 2026 Feb 3:e0152825. doi: 10.1128/aac.01528.
PubMed Abstract available

January 2026

LEPAK A, Bhavnani SM, Castanheira M, Rubino CM, et al
Evaluation of an in vivo pulmonary aspergillosis model for triazole susceptibility breakpoint development.
Antimicrob Agents Chemother. 2026 Jan 30:e0164325. doi: 10.1128/aac.01643.
PubMed Abstract available

ARUN B, Sharma R, Valle Q, Bui NM, et al
A genomics-informed mechanism-based pharmacokinetic/pharmacodynamic model of cefiderocol and ceftazidime/avibactam against carbapenem-resistant Achromobacter xylosoxidans.
Antimicrob Agents Chemother. 2026 Jan 26:e0126325. doi: 10.1128/aac.01263.
PubMed Abstract available

SHARMA P, Dean D, Read TD
Putative azithromycin resistance mutations in Chlamydia trachomatis are globally distributed but arose before azithromycin was discovered.
Antimicrob Agents Chemother. 2026 Jan 26:e0170825. doi: 10.1128/aac.01708.
PubMed Abstract available

ZHOU W, Chen D, Dong X, Yang T, et al
Emergence and genomic adaptation of the globally disseminated ST2250 lineage within the Staphylococcus aureus complex.
Antimicrob Agents Chemother. 2026 Jan 26:e0162825. doi: 10.1128/aac.01628.
PubMed Abstract available

SHAO Y, Lan X, Zhang X, Wang L, et al
fosZ, a novel plasmid-borne fosfomycin resistance gene in Pseudomonas species, especially carbapenem-resistant Pseudomonas aeruginosa isolates.
Antimicrob Agents Chemother. 2026 Jan 14:e0075025. doi: 10.1128/aac.00750.
PubMed Abstract available

ANEKE CI, Shahegh SS, Freeman AF, Zerbe C, et al
Beyond Fumigatus: a molecular portrait of clinical Aspergillus diversity, pathogenicity, and antifungal resistance.
Antimicrob Agents Chemother. 2026 Jan 13:e0118425. doi: 10.1128/aac.01184.
PubMed Abstract available

CASTANHEIRA M, Kimbrough JH, Morgan GM, Karr M, et al
Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-beta-lactamase-producing Enterobacterales.
Antimicrob Agents Chemother. 2026;70:e0084225.
PubMed Abstract available

LACKNER M, Toepfer S, Keniya MV, Lax C, et al
The molecular basis of intrinsic resistance to azoles in Rhizopus arrhizus.
Antimicrob Agents Chemother. 2026;70:e0133725.
PubMed Abstract available

VAN HELDEN SR, Bleick CR, Holger DJ, El Ghali A, et al
Impact of Pseudomonas aeruginosa biofilm exopolysaccharide composition on bacteriophage and bacteriophage-antibiotic combination activity.
Antimicrob Agents Chemother. 2026;70:e0092525.
PubMed Abstract available

VARIK V, Wang G, Kritikos G, Banzhaf M, et al
Synergistic activity of rifampicin and polymyxin B against intracellular Gram-negative ESKAPE pathogens involves bacterial membrane alterations and enhanced oxidative damages.
Antimicrob Agents Chemother. 2026;70:e0131925.
PubMed Abstract available

December 2025

LLORENTE J, Sempere J, Llamosi M, Perez-Garcia C, et al
Emergence of antibiotic-resistant pneumococcal serotypes causing invasive pneumococcal disease in children, Spain.
Antimicrob Agents Chemother. 2025 Dec 31:e0153025. doi: 10.1128/aac.01530.
PubMed Abstract available

LUO J, Liu M, Ai W, Zheng X, et al
Gtr9 mutation trades phage resistance for carbapenem sensitivity to potentiate phage-meropenem therapy against carbapenem-resistant Acinetobacter baumannii in vitro.
Antimicrob Agents Chemother. 2025 Dec 30:e0135525. doi: 10.1128/aac.01355.
PubMed Abstract available

HINTERWIRTH A, Chen C, Yan D, Zhong L, et al
Co-selection of genetic antibiotic resistance in Streptococcus pneumoniae after repeated azithromycin mass drug administrations in Niger.
Antimicrob Agents Chemother. 2025 Dec 23:e0156225. doi: 10.1128/aac.01562.
PubMed Abstract available

PARK J, Choi S, Jeon YR, Kim L-H, et al
Evaluation of clofazimine-bedaquiline combination as a candidate regimen for macrolide-resistant Mycobacterium avium complex infection.
Antimicrob Agents Chemother. 2025 Dec 19:e0151125. doi: 10.1128/aac.01511.
PubMed Abstract available

MAHADEVAN R, Garcia E, Sharma R, Qiu H, et al
A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant Klebsiella pneumoniae isolates with diverse phenotypic and genotypic resistance mechanisms.
Antimicrob Agents Chemother. 2025 Dec 19:e0078225. doi: 10.1128/aac.00782.
PubMed Abstract available

LEONARD VHJ, Vidales DB, Taft BR, Hesse MJ, et al
Identification and characterization of a novel inhibitor of influenza A virus that acts by blocking nucleoprotein oligomerization.
Antimicrob Agents Chemother. 2025 Dec 19:e0114925. doi: 10.1128/aac.01149.
PubMed Abstract available

APPLEBACH E, Amburgey-Crovetti K, Bakotic WL, Adhikari TB, et al
Prevalence and diversity of antifungal resistance in Fusarium isolates across clinical and agricultural settings in the United States.
Antimicrob Agents Chemother. 2025;69:e0120825.
PubMed Abstract available

NODARI CS, Bai Q, Cayo R, Streling AP, et al
ISAba1-mediated bla(ADC) disruption restores third-generation cephalosporin susceptibility in a clinical Acinetobacter baumannii isolate.
Antimicrob Agents Chemother. 2025;69:e0070725.
PubMed Abstract available

CADENAS-JIMENEZ I, Gonzalez-Diaz A, Berbel D, Costa-Primo R, et al
First report of a DIM-1-producing Pseudomonas aeruginosa in Spain: genomic characterization and resistance determinants.
Antimicrob Agents Chemother. 2025;69:e0131125.
PubMed Abstract available

HESELPOTH RD, Euler CW, Fischetti VA
Second-generation lysocins as therapeutics for treating Pseudomonas aeruginosa infections.
Antimicrob Agents Chemother. 2025;69:e0131225.
PubMed Abstract available

HUSSEIN M, Crawford S, Baker M, Floyd H, et al
Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress.
Antimicrob Agents Chemother. 2025;69:e0100725.
PubMed Abstract available

ALVARADO-OROSCO N, Gomis-Font MA, Sastre-Femenia MA, Ribera Ortiz S, et al
First nationwide survey on Pseudomonas aeruginosa in Bolivia: susceptibility profiles, resistome, and genomic epidemiology.
Antimicrob Agents Chemother. 2025;69:e0116325.
PubMed Abstract available

WANGCHINDA W, Wu JY, Abbo LM, Ackley R, et al
Effectiveness of imipenem-relebactam for multidrug-resistant Pseudomonas aeruginosa in pneumonia and bloodstream infections in the United States (MIRAGE).
Antimicrob Agents Chemother. 2025;69:e0132525.
PubMed Abstract available

FU Y, Zhang Y, Zhao J, Xie J, et al
Emergence of co-resistance to imipenem/relebactam and ceftazidime/avibactam in clinical Klebsiella pneumoniae ST11 clone due to KPC-2 N132S and CTX-M-65 S130G/P167S substitutions.
Antimicrob Agents Chemother. 2025;69:e0089125.
PubMed Abstract available

VANACHAYANGKUL P, Ruamsap N, Caridha D, Imerbsin R, et al
Preclinical in vitro and in vivo evaluation of omadacycline against multidrug-resistant Acinetobacter baumannii.
Antimicrob Agents Chemother. 2025;69:e0093225.
PubMed Abstract available

KENT JE, Elane M, Leyn S, Zlamal J, et al
Mutations in two-component signaling systems drive experimental evolution of tigecycline and colistin resistance in Acinetobacter baumannii.
Antimicrob Agents Chemother. 2025;69:e0080925.
PubMed Abstract available

COOPER K, Murthy K, Balzer T, Parkinson S, et al
In vitro and in vivo characterization of Bisphosphocin Nu-3-a novel broad-spectrum antimicrobial compound with high potency against resistant pathogens.
Antimicrob Agents Chemother. 2025;69:e0094825.
PubMed Abstract available

TAKEI K, Kanamori H, Sakata R, Ogawa M, et al
High-risk clonal expansion of IMP-producing Enterobacter cloacae complex in regional Japanese healthcare settings.
Antimicrob Agents Chemother. 2025;69:e0095325.
PubMed Abstract available

YOUSSEF EG, Gebremariam T, Gu Y, Patterson H, et al
Efficacy assessments of EL219, a next-generation polyene antifungal, in immunosuppressed mice infected with drug-sensitive and drug-resistant Aspergillus isolates.
Antimicrob Agents Chemother. 2025 Dec 5:e0140025. doi: 10.1128/aac.01400.
PubMed Abstract available

November 2025

FUNK OG, Li J, Khan I, Cusumano JA, et al
Ceftobiprole alone versus ampicillin-ceftriaxone against borderline-penicillin-resistant, ampicillin-susceptible, and vancomycin-resistant Enterococcus faecalis isolates.
Antimicrob Agents Chemother. 2025 Nov 24:e0105025. doi: 10.1128/aac.01050.
PubMed Abstract available

LAVOIE T, Sierra T, Daffinee K, Pogue JM, et al
Unlocking potentials: the impact of meropenem, meropenem-vaborbactam, and ceftazidime-avibactam in combating carbapenem-resistant Enterobacter cloacae.
Antimicrob Agents Chemother. 2025 Nov 19:e0090625. doi: 10.1128/aac.00906.
PubMed Abstract available

HASHIMOTO Y, Dao DT, Kasuga I, Takemura T, et al
Ongoing independent evolution of linezolid and vancomycin-resistance pELF-type linear plasmids across the One Health spectrum.
Antimicrob Agents Chemother. 2025 Nov 18:e0116825. doi: 10.1128/aac.01168.
PubMed Abstract available

DARNELL RL, Knottenbelt MK, Rose OE, Cleary CSB, et al
Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis.
Antimicrob Agents Chemother. 2025 Nov 18:e0062925. doi: 10.1128/aac.00629.
PubMed Abstract available

BEH JQ, Wick RR, Howden BP, Connor CH, et al
Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations.
Antimicrob Agents Chemother. 2025 Nov 11:e0109725. doi: 10.1128/aac.01097.
PubMed Abstract available

FINDLAY J, Nordmann P, Jayol A, Seth-Smith HMB, et al
Carbapenem resistance in a Klebsiella quasipneumoniae isolate resulting from production of CTX-M-33 and OmpK36 porin deficiency.
Antimicrob Agents Chemother. 2025 Nov 6:e0121425. doi: 10.1128/aac.01214.
PubMed

HE G, Zeng S, Banki LT, Zhou W, et al
Clinical emergence of inducible macrolide resistance mediated by acquired erm(41) C28T mutation in Mycobacterium abscessus.
Antimicrob Agents Chemother. 2025 Nov 6:e0115325. doi: 10.1128/aac.01153.
PubMed Abstract available

XUE R, Gao S, de Hoog S, van Diepeningen A, et al
Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability.
Antimicrob Agents Chemother. 2025;69:e0096125.
PubMed Abstract available

WIEDERHOLD NP
Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child.
Antimicrob Agents Chemother. 2025;69:e0107225.
PubMed Abstract available

MASSIC L, Doorley LA, Jones SJ, Richardson I, et al
Acquired amphotericin B resistance attributed to a mutated ERG3 in Candidozyma auris.
Antimicrob Agents Chemother. 2025;69:e0060125.
PubMed Abstract available

RAMIREZ D, Ramirez DM, Arora R, Arthur G, et al
Noncytotoxic polymyxin derivatives enhance antibiotic action against multidrug-resistant Gram-negative bacteria.
Antimicrob Agents Chemother. 2025;69:e0071225.
PubMed Abstract available

KUNZ COYNE AJ, Gray R, May E, Curry H, et al
Molecular and pharmacodynamic insights into beta-lactam therapy for high-inoculum Enterobacter cloacae complex infections.
Antimicrob Agents Chemother. 2025;69:e0117025.
PubMed Abstract available

WANG C, Feng Y, Zong Z
Colistin heteroresistance in Enterobacter due to base heterozygosity at certain phoP and phoQ locations.
Antimicrob Agents Chemother. 2025;69:e0071325.
PubMed Abstract available

LODISE TP, Min J, Nathanson BH, Yucel E, et al
Comparison of early treatment with ceftolozane/tazobactam versus polymyxin-based therapy of pneumonia due to MDR Pseudomonas aeruginosa (PUMA).
Antimicrob Agents Chemother. 2025;69:e0056925.
PubMed Abstract available

MORAN-BARRIO J, Giacone L, Brambilla L, Fabbri C, et al
The lipoprotein biosynthesis pathway: key to OXA-mediated carbapenem resistance in Acinetobacter baumannii.
Antimicrob Agents Chemother. 2025 Nov 4:e0109925. doi: 10.1128/aac.01099.
PubMed Abstract available

MOHAMAD M, Hurst MM, Elkrewi E, Randall CP, et al
Nature of bacitracin resistance in Staphylococcus aureus.
Antimicrob Agents Chemother. 2025 Nov 4:e0087525. doi: 10.1128/aac.00875.
PubMed Abstract available

October 2025

HODBERT E, Lemenand O, Thibaut S, Coeffic T, et al
Exploring multidrug resistance patterns in community-acquired Escherichia coli urinary tract infections with machine learning.
Antimicrob Agents Chemother. 2025 Oct 31:e0042225. doi: 10.1128/aac.00422.
PubMed Abstract available

SUN L, Lei T, Liu Y, Lu S, et al
In vivo development of elevated linezolid resistance mediated by a deletion in ribosomal protein L3 in clinical Enterococcus faecium.
Antimicrob Agents Chemother. 2025 Oct 28:e0087125. doi: 10.1128/aac.00871.
PubMed Abstract available

MARCH VFA, Zwyer M, Loiseau C, Brites D, et al
Variability in intrinsic drug tolerance in Mycobacterium tuberculosis corresponds with phylogenetic lineage.
Antimicrob Agents Chemother. 2025 Oct 21:e0099625. doi: 10.1128/aac.00996.
PubMed Abstract available

SHAW S, Pragasam AK, Chowdhury G, Samanta P, et al
Genomic portrayal of emerging carbapenem-resistant El Tor variant Vibrio cholerae O1.
Antimicrob Agents Chemother. 2025 Oct 17:e0074025. doi: 10.1128/aac.00740.
PubMed Abstract available

FRIAES A, Mamede R, Santos B, Marrao G, et al
Increase of macrolide resistance among Streptococcus pyogenes pharyngitis driven by a mef(A)-msr(D)/emm2-ST55 lineage in Portugal (2014-2019).
Antimicrob Agents Chemother. 2025 Oct 10:e0096825. doi: 10.1128/aac.00968.
PubMed Abstract available

ALVARADO CASAS ML, Triana Diaz JA, Montilla-Escudero E, Prada Cardozo DA, et al
Genomic epidemiology of Colombian resistant Candida auris isolates.
Antimicrob Agents Chemother. 2025 Oct 7:e0072525. doi: 10.1128/aac.00725.
PubMed Abstract available

DONG X, Xiang Y, Li Y, Zhang Y, et al
Lineage-specific evolution and resistance-virulence divergence in Klebsiella pneumoniae ST268: a global population genomic analysis.
Antimicrob Agents Chemother. 2025;69:e0070325.
PubMed Abstract available

RAKA V, Jangra M, Kaur P, Dadwal R, et al
Preclinical evaluation of tridecaptin M: in vitro and in vivo efficacy against colistin-resistant Gram-negative bacterial pathogens and pharmacokinetics.
Antimicrob Agents Chemother. 2025;69:e0108325.
PubMed Abstract available

ALARCON RIOS AC, Zwep LB, Vriesendorp B, Knibbe CAJ, et al
Colistin resistance dynamics in Pseudomonas aeruginosa under biofilm and planktonic growth.
Antimicrob Agents Chemother. 2025;69:e0042125.
PubMed Abstract available

WAN T-W, Shintani M, Kojima KK, Moriguchi N, et al
Transposition of Tn552-II (a Tn552 derivative) to the conjugative pCtra plasmid family in pediatric multidrug-resistant community-associated MRSA.
Antimicrob Agents Chemother. 2025;69:e0064725.
PubMed Abstract available

September 2025

VENA A, Bartalucci C, Muccio M, Tiseo G, et al
Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant Candida parapsilosis bloodstream infections.
Antimicrob Agents Chemother. 2025 Sep 30:e0035525. doi: 10.1128/aac.00355.
PubMed Abstract available

SHINOHARA T, Wada A, Abe M, Oiki S, et al
A zinc-chelating cyclic alkyl polyamine compound is efficient and safe in a murine model of multidrug-resistant Candida auris infection.
Antimicrob Agents Chemother. 2025 Sep 26:e0085625. doi: 10.1128/aac.00856.
PubMed Abstract available

PETERSEN S, Diricks M, Utpatel C, Schulenburg H, et al
Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.
Antimicrob Agents Chemother. 2025 Sep 22:e0057625. doi: 10.1128/aac.00576.
PubMed Abstract available

ZENG Q, Huang H, Lu J, Wu L, et al
Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study.
Antimicrob Agents Chemother. 2025 Sep 22:e0064425. doi: 10.1128/aac.00644.
PubMed Abstract available

SICELOFF AT, Ohta N, Norman KN, Loneragan GH, et al
Correction for Siceloff et al., "Antimicrobial Resistance Hidden within Multiserovar Salmonella Populations".
Antimicrob Agents Chemother. 2025 Sep 18:e0092625. doi: 10.1128/aac.00926.
PubMed

MARTIN-VICENTE A, Nywening AV, Xie J, Thorn HI, et al
Genetic analysis of common triazole resistance mechanisms in a collection of Aspergillus lentulus clinical isolates from the United States.
Antimicrob Agents Chemother. 2025 Sep 12:e0069025. doi: 10.1128/aac.00690.
PubMed Abstract available

TURNER AM, Kinsella P, Miller WR, Carter GP, et al
Therapeutic approach to difficult-to-treat multidrug-resistant enterococcal infections.
Antimicrob Agents Chemother. 2025 Sep 11:e0106024. doi: 10.1128/aac.01060.
PubMed Abstract available

SCANGARELLA-OMAN NE, Butler DL, Breton J, Brown D, et al
Efficacy and in vitro activity of gepotidacin against bacterial uropathogens, including subsets with molecularly characterized resistance mechanisms and genotypes/epidemiological clones, in females with uncomplicated urinary tract infections: results
Antimicrob Agents Chemother. 2025 Sep 9:e0163924. doi: 10.1128/aac.01639.
PubMed Abstract available

SCANGARELLA-OMAN NE, Butler DL, Breton J, Brown D, et al
Efficacy and in vitro activity of gepotidacin against bacterial uropathogens, including drug-resistant phenotypes, in females with uncomplicated urinary tract infections: results from two global, pivotal, phase 3 trials (EAGLE-2 and EAGLE-3).
Antimicrob Agents Chemother. 2025 Sep 9:e0164024. doi: 10.1128/aac.01640.
PubMed Abstract available

YU H, Peng W, Li H, Zhang Y, et al
Agricultural propiconazole residues promote triazole cross-resistance in Cryptococcus neoformans through ERG11 and efflux pump overexpression.
Antimicrob Agents Chemother. 2025;69:e0076525.
PubMed Abstract available

CASTILLO-RAMIREZ S, Aguilar-Vera A, Kumar A, Evans B, et al
Acinetobacter baumannii: much more than a human pathogen.
Antimicrob Agents Chemother. 2025;69:e0080125.
PubMed Abstract available

WANG C, Huang H, Valera L, Parcella K, et al
Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499.
Antimicrob Agents Chemother. 2025 Sep 3:e0030925. doi: 10.1128/aac.00309.
PubMed Abstract available

August 2025

LAI Y-T, Dingens AS, DeMouth M, Helmold Hait S, et al
Fostemsavir analog BMS-818251 has enhanced viral neutralization potency and similar escape mutation profile.
Antimicrob Agents Chemother. 2025 Aug 27:e0191024. doi: 10.1128/aac.01910.
PubMed Abstract available

REITLER P, DeJarnette CA, Kumar R, Tucker KM, et al
A screen to identify antifungal antagonists reveals a variety of pharmacotherapies that induce echinocandin tolerance in Candida albicans.
Antimicrob Agents Chemother. 2025 Aug 18:e0048425. doi: 10.1128/aac.00484.
PubMed Abstract available

BARKER KS, Santana DJ, Zhang Q, Peters TL, et al
Mutations in TAC1B drive increased CDR1 and MDR1 expression and azole resistance in Candida auris.
Antimicrob Agents Chemother. 2025 Aug 18:e0030025. doi: 10.1128/aac.00300.
PubMed Abstract available

BUYUKYANBOLU E, Argotsinger J, Beck ET, Chamberland RR, et al
Activity of ampicillin-sulbactam, sulbactam-durlobactam, and comparators against Acinetobacter baumannii-calcoaceticus complex strains isolated from respiratory and bloodstream sources: results from ACNBio study.
Antimicrob Agents Chemother. 2025;69:e0037925.
PubMed Abstract available

KUBIN CJ, Garzia C, Uhlemann A-C
Acinetobacter baumannii treatment strategies: a review of therapeutic challenges and considerations.
Antimicrob Agents Chemother. 2025;69:e0106324.
PubMed Abstract available

SARAL SARIYER A, Leus IV, Tambat R, Farjana M, et al
Mutations in the proximal binding site and F-loop of AdeJ confer resistance to efflux pump inhibitors.
Antimicrob Agents Chemother. 2025;69:e0009025.
PubMed Abstract available

MELETIADIS J, Jorgensen KM, Astvad KMT, Abou-Chakra N, et al
EUCAST olorofim MICs for 3,550 Danish mold and dermatophyte isolates from 2020 to 2023.
Antimicrob Agents Chemother. 2025;69:e0035325.
PubMed Abstract available

ZHANG W, Peng K, Liu M, Luo X, et al
Detection of SXT/R391 integrative conjugative elements carrying tigecycline resistance genes in Shewanella spp. isolated from retail seafood.
Antimicrob Agents Chemother. 2025;69:e0174224.
PubMed Abstract available

VAHEDI-SHAHANDASHTI R, Hofer I, Leighton H, Fothergill J, et al
The impact of respiratory tract mimicking media on antifungal susceptibility testing.
Antimicrob Agents Chemother. 2025;69:e0022525.
PubMed Abstract available

OJHA S, Chatterjee P, Beuria TK
Inhibition of efflux pumps by FDA-approved drugs oxiconazole and sertaconazole restores antibiotic susceptibility in multidrug-resistant S. aureus.
Antimicrob Agents Chemother. 2025 Aug 4:e0032025. doi: 10.1128/aac.00320.
PubMed Abstract available

July 2025

VIDUCIC D, Obranic S, Matovina M, Babic F, et al
Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens.
Antimicrob Agents Chemother. 2025 Jul 31:e0074225. doi: 10.1128/aac.00742.
PubMed Abstract available

NONG L, Liu X, Wang X, de Leeuw W, et al
Driving factors for beta-lactam resistance gene amplification during de novo resistance evolution in E. coli.
Antimicrob Agents Chemother. 2025 Jul 23:e0044125. doi: 10.1128/aac.00441.
PubMed Abstract available

FANG Y, Song M, Zhang Y, Wu Z, et al
Evolution of XDR Pseudomonas aeruginosa ST463 strains with two plasmids harboring multiple antimicrobial resistance genes.
Antimicrob Agents Chemother. 2025 Jul 23:e0169724. doi: 10.1128/aac.01697.
PubMed Abstract available

YAMADA AY, de Souza AR, Madalosso G, de Assis DB, et al
Emergence of carbapenem-resistant Acinetobacter baumannii clonal complex 2 in multiple hospitals in Sao Paulo state, Brazil.
Antimicrob Agents Chemother. 2025 Jul 23:e0186524. doi: 10.1128/aac.01865.
PubMed Abstract available

WU Y, Dai Y, Lu H, Jiang X, et al
Osh2 mediates Candida species resistance to miltefosine by regulating zymosterol accumulation.
Antimicrob Agents Chemother. 2025 Jul 23:e0042725. doi: 10.1128/aac.00427.
PubMed Abstract available

BARKER KS, Patterson HP, Morschhauser J, Cuomo CA, et al
Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris (Candidozyma auris), Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus).
Antimicrob Agents Chemother. 2025 Jul 23:e0068025. doi: 10.1128/aac.00680.
PubMed Abstract available

TUANYOK A, Nakajima C, Noll T, Khan MSR, et al
Genomic insights into ceftazidime resistance in Burkholderia pseudomallei: discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating penA duplication and amplification.
Antimicrob Agents Chemother. 2025 Jul 21:e0022025. doi: 10.1128/aac.00220.
PubMed Abstract available

BELLO-LOPEZ E, Kawabata A, Cantero J, Mendoza S, et al
Genomic epidemiology reveals antibiotic resistance transfer and polyclonal dissemination of Acinetobacter baumannii in a Paraguayan hospital.
Antimicrob Agents Chemother. 2025 Jul 8:e0007725. doi: 10.1128/aac.00077.
PubMed Abstract available

GATTI M, Rinaldi M, Cojutti PG, Bonazzetti C, et al
A pre-post quasi-experimental study of antimicrobial stewardship exploring the impact of a multidisciplinary approach aimed at attaining an aggressive joint pharmacokinetic/pharmacodynamic target with ceftazidime/avibactam on treatment outcome of KPC-
Antimicrob Agents Chemother. 2025;69:e0048825.
PubMed Abstract available

HOU Y, Pi R, Jia J, Wu Z, et al
Limited predictive power of known resistance genes for phenotypic drug resistance in clinical Mycobacterium abscessus complex from Beijing in China.
Antimicrob Agents Chemother. 2025;69:e0184724.
PubMed Abstract available

FERRREIRA CDO, Leturiondo AL, Dos Santos CG, da Silva JB, et al
Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.
Antimicrob Agents Chemother. 2025;69:e0155024.
PubMed Abstract available

OUTEDA-GARCIA M, Garcia-Pose A, Guijarro-Sanchez P, Rodriguez-Coello A, et al
The novel polymyxin analogue SPR206 exhibits higher activity than colistin against both colistin-susceptible and colistin-resistant strains of Acinetobacter baumannii.
Antimicrob Agents Chemother. 2025;69:e0194024.
PubMed Abstract available

RAJAKANI SG, Xavier BB, Nguyen NM, Lin Q, et al
Characterization of genome-wide transpositions induced by colistin exposure in multi-drug-resistant Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2025;69:e0157424.
PubMed Abstract available

VAHEDI-SHAHANDASHTI R, Moroder E, Lass-Florl C
Candida parapsilosis and echinocandins: should the clinical laboratory drop anidulafungin Etest from the susceptibility testing panel?
Antimicrob Agents Chemother. 2025 Jul 1:e0024125. doi: 10.1128/aac.00241.
PubMed Abstract available

June 2025

ANDREANI J, Truffot A, Tilloy V, Jardin H, et al
Long-range PCRs and next-generation sequencing to detect cytomegalovirus drug resistance-associated mutations.
Antimicrob Agents Chemother. 2025 Jun 25:e0014125. doi: 10.1128/aac.00141.
PubMed Abstract available

AI Q, Wang S, Chen Z, Zheng S, et al
Synergistic antibacterial activity and prevention of drug resistance of daptomycin combined with fosfomycin against methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2025 Jun 18:e0160924. doi: 10.1128/aac.01609.
PubMed Abstract available

LEUS IV, Zgurskaya HI
No two are alike: on the role of Klebsiella pneumoniae permeability barriers in antibiotic susceptibility and persistence.
Antimicrob Agents Chemother. 2025 Jun 17:e0008525. doi: 10.1128/aac.00085.
PubMed Abstract available

MEEKES LM, Heikema AP, Tompa M, Astorga Alsina AL, et al
Proteogenomic analysis demonstrates increased bla(OXA-48) copy numbers and OmpK36 loss as contributors to carbapenem resistance in Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2025 Jun 13:e0010725. doi: 10.1128/aac.00107.
PubMed Abstract available

WANG K, Xu J, Lu X, Yin P, et al
Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.
Antimicrob Agents Chemother. 2025 Jun 12:e0169524. doi: 10.1128/aac.01695.
PubMed Abstract available

WAITES JT, Crabb DM, Ratliff AE, Waites KB, et al
Antimicrobial susceptibility and genetic mechanisms of resistance of Ureaplasma isolates in North America between 2012 and 2023.
Antimicrob Agents Chemother. 2025;69:e0186824.
PubMed Abstract available

MATEO-VARGAS MA, Rodriguez-Pallares S, Arca-Suarez J, Lopez-Cerero L, et al
Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants.
Antimicrob Agents Chemother. 2025;69:e0149424.
PubMed Abstract available

May 2025

LIU X, Qu X, Zhang R, Zhang Y, et al
Synergistic combination of next-generation polymyxin MRX-8 and meropenem against carbapenem-resistant A. baumannii.
Antimicrob Agents Chemother. 2025 May 27:e0191224. doi: 10.1128/aac.01912.
PubMed Abstract available

XIE L, Li J, Peng Q, Liu X, et al
Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYE.
Antimicrob Agents Chemother. 2025 May 23:e0185824. doi: 10.1128/aac.01858.
PubMed Abstract available

NELSON ME, Little JL, Kristich CJ
Correction for Nelson et al., "Pbp4 provides transpeptidase activity to the FtsW-PbpB peptidoglycan synthase to drive cephalosporin resistance in Enterococcus faecalis".
Antimicrob Agents Chemother. 2025 May 20:e0059425. doi: 10.1128/aac.00594.
PubMed

LI X, Zhou L, Wang D, Wu Q, et al
Population pharmacokinetics study on nebulized and intravenous administration of polymyxin B in patients with pneumonia caused by multidrug-resistant gram-negative bacteria.
Antimicrob Agents Chemother. 2025;69:e0004425.
PubMed Abstract available

HIKAL AF, Zhao S, Foley S, Khan AA, et al
The newly identified grdA gene confers high-level plazomicin resistance in Salmonella enterica serovars.
Antimicrob Agents Chemother. 2025;69:e0160624.
PubMed Abstract available

LACROIX M, Moreau J, Zampaloni C, Bissantz C, et al
In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii.
Antimicrob Agents Chemother. 2025;69:e0153524.
PubMed Abstract available

April 2025

LEE J, Lee I, Lee K-B, Lee SS, et al
Comparative effectiveness and safety of colistin-based versus high-dose ampicillin/sulbactam-based combination therapy for nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii.
Antimicrob Agents Chemother. 2025 Apr 23:e0188024. doi: 10.1128/aac.01880.
PubMed Abstract available

ZHANG Y, Zhou B, Kong J, Hu P, et al
Prevalence and characteristics of tigecycline- and carbapenem-resistant adeN-truncated Acinetobacter baumannii: a genomic epidemiological analysis.
Antimicrob Agents Chemother. 2025 Apr 23:e0184324. doi: 10.1128/aac.01843.
PubMed Abstract available

SZEL V, Phelan JE, Georghiou SB, Dolinger DL, et al
The ahpC c-54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 2025 Apr 22:e0026525. doi: 10.1128/aac.00265.
PubMed Abstract available

SHERRY NL, Lee JYH, Giulieri SG, Connor CH, et al
Genomics for antimicrobial resistance-progress and future directions.
Antimicrob Agents Chemother. 2025 Apr 14:e0108224. doi: 10.1128/aac.01082.
PubMed Abstract available

ARDIZZONI E, Mulders W, De Diego Fuertes M, Hayrapetyan A, et al
Phenotypic and genotypic resistance to bedaquiline in patients with multi-drug-resistant tuberculosis-experiences from Armenia.
Antimicrob Agents Chemother. 2025 Apr 9:e0183924. doi: 10.1128/aac.01839.
PubMed Abstract available

HUANG H, Chen Y, Zhang L, Wan P, et al
Identification and characterization of a novel major facilitator superfamily (MFS) efflux pump conferring multidrug resistance in Staphylococcus aureus and Staphylococcus epidermidis.
Antimicrob Agents Chemother. 2025 Apr 7:e0173924. doi: 10.1128/aac.01739.
PubMed Abstract available

SASTRE-FEMENIA MA, Gomis-Font MA, Oliver A
Mutant prevention concentrations and phenotypic and genomic profiling of first-step resistance mechanisms to classical and novel beta-lactams in Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2025;69:e0194224.
PubMed Abstract available

SADER HS, Castanheira M, Arends SJR, Doyle TB, et al
Antimicrobial susceptibility of Stenotrophomonas maltophilia from United States medical centers (2019-2023).
Antimicrob Agents Chemother. 2025;69:e0012425.
PubMed Abstract available

SAMPER-CATIVIELA C, Torre-Fuentes L, Dieguez-Roda B, Maex M, et al
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
Antimicrob Agents Chemother. 2025;69:e0073824.
PubMed Abstract available

MA Y, Pirolo M, Giarratana L, Leth Nielsen K, et al
Chromosomal genes modulating fosfomycin susceptibility in uropathogenic Escherichia coli: a genome-wide analysis.
Antimicrob Agents Chemother. 2025;69:e0141724.
PubMed Abstract available

PROENCA AM, Rang CU, Chao L
A link between aging and persistence.
Antimicrob Agents Chemother. 2025;69:e0131324.
PubMed Abstract available

HUSSAIN A, Bhando T, Casius A, Gupta R, et al
Deciphering meropenem persistence in Acinetobacter baumannii facilitates discovery of anti-persister activity of thymol.
Antimicrob Agents Chemother. 2025;69:e0138124.
PubMed Abstract available

March 2025

SONG Y, An Q, Chen S, Dai H, et al
Antimicrobial resistance of pet-derived bacteria in China, 2000-2020.
Antimicrob Agents Chemother. 2025 Mar 26:e0165724. doi: 10.1128/aac.01657.
PubMed Abstract available

PEROUTKA-BIGUS N, Brooks EJ, Ramey ME, D'Erasmo H, et al
Contribution of front-line, standard-of-care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease.
Antimicrob Agents Chemother. 2025 Mar 26:e0190124. doi: 10.1128/aac.01901.
PubMed Abstract available

HUANG H, Wan P, Chen Y, Luo X, et al
Phenotypic and genetic stepwise changes in Staphylococcus aureus during in vitro adaptive laboratory evolution under the selective pressure of tigecycline.
Antimicrob Agents Chemother. 2025 Mar 26:e0007225. doi: 10.1128/aac.00072.
PubMed Abstract available

KIM M-J, Zarnowski R, Jones R, Nett JE, et al
Vesicle inhibition reduces Candida biofilm resistance.
Antimicrob Agents Chemother. 2025 Mar 26:e0004525. doi: 10.1128/aac.00045.
PubMed Abstract available

MAHE A, Verneuil N, Coupri D, Hartke A, et al
D-alanylation of lipoteichoic acids inhibitor provides anti-virulence and anti-resistance effects against methicillin-resistant Staphylococcus epidermidis.
Antimicrob Agents Chemother. 2025 Mar 21:e0182224. doi: 10.1128/aac.01822.
PubMed Abstract available

MUNITA JM, Tamma PD
Fighting resistance with redundancy: a path forward for treating antimicrobial-resistant infections?
Antimicrob Agents Chemother. 2025 Mar 14:e0012125. doi: 10.1128/aac.00121.
PubMed Abstract available

PETERSEN ME, Khamas AB, Ostergaard LJ, Jorgensen NP, et al
Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus.
Antimicrob Agents Chemother. 2025 Mar 14:e0148324. doi: 10.1128/aac.01483.
PubMed Abstract available

ZHAO L, Li C, Wang M, Zhou M, et al
Potent antiviral activity of simnotrelvir against key epidemic SARS-CoV-2 variants with a high resistance barrier.
Antimicrob Agents Chemother. 2025 Mar 10:e0155624. doi: 10.1128/aac.01556.
PubMed Abstract available

YU Z, Hu H, Liu X, Liu J, et al
Clinical outcomes and pharmacokinetics/pharmacodynamics of intravenous polymyxin B treatment for various site carbapenem-resistant gram-negative bacterial infections: a prospective observational multicenter study.
Antimicrob Agents Chemother. 2025 Mar 6:e0185924. doi: 10.1128/aac.01859.
PubMed Abstract available

LEMAITRE N, Dewitte A, Rakotomanimana F, Gooden D, et al
Assessing the threat of Yersinia pestis harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC.
Antimicrob Agents Chemother. 2025;69:e0149724.
PubMed Abstract available

ROJAS LJ, Nielsen TB, Pantapalangkoor P, Taracila MA, et al
Restoring cefepime activity against multidrug-resistant KPC-producing Klebsiella pneumoniae by combination with boronic acid inhibitors, MB076 and S02030.
Antimicrob Agents Chemother. 2025;69:e0096424.
PubMed Abstract available

DORAZIO AJ, Kline EG, Squires KM, Pogue JM, et al
Restoring ceftolozane susceptibility: a role for diazabicyclooctane beta-lactamase inhibitors?
Antimicrob Agents Chemother. 2025;69:e0154324.
PubMed Abstract available

CORNISTEIN W, Balasini C, Nuccetelli Y, Rodriguez VM, et al
Prevalence and mortality associated with multidrug-resistant infections in adult intensive care units in Argentina (PREV-AR).
Antimicrob Agents Chemother. 2025;69:e0142624.
PubMed Abstract available

February 2025

YU H, Wang L, Liu X, Zheng J, et al
Mechanistic insights into the multitarget synergistic efficacy of farrerol and beta-lactam antibiotics in combating methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2025 Feb 28:e0155124. doi: 10.1128/aac.01551.
PubMed Abstract available

FU S-Y, Chen X-Z, Yi P-C, Gao J, et al
Optimizing phage therapy for carbapenem-resistant Enterobacter cloacae bacteremia: insights into dose and timing.
Antimicrob Agents Chemother. 2025 Feb 26:e0168324. doi: 10.1128/aac.01683.
PubMed Abstract available

FILE TM JR, Ramirez JA, Wilde AM
New Perspectives on Antimicrobial Agents: Omadacycline for community-acquired pneumonia, skin and soft tissue infections, and nontuberculous mycobacteria (focus on M. abscessus).
Antimicrob Agents Chemother. 2025;69:e0108724.
PubMed Abstract available

BONCOMPAGNI SR, Riccobono E, Cusi MG, Di Pilato V, et al
Evidence of dissemination of a clc-type integrative and conjugative element to Stenotrophomonas maltophilia, mediating acquisition of sul1 and other resistance determinants.
Antimicrob Agents Chemother. 2025;69:e0155424.
PubMed Abstract available

ROSON-CALERO N, Gomis Font MA, Ruiz-Soriano A, Just-Baringo X, et al
In vitro potentiation of tetracyclines in Pseudomonas aeruginosa by RW01, a new cyclic peptide.
Antimicrob Agents Chemother. 2025;69:e0145924.
PubMed Abstract available

RODRIGUEZ L, Lee HW, Li J, Martin R, et al
SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants.
Antimicrob Agents Chemother. 2025;69:e0123824.
PubMed Abstract available

GHEBREKRISTOS Y, Ahmed A, Beylis N, Singh S, et al
Xpert MTB/RIF Ultra-resistant and MTBDRplus-susceptible rifampicin results in people with tuberculosis: utility of FluoroType MTBDR and deep sequencing.
Antimicrob Agents Chemother. 2025 Feb 7:e0167124. doi: 10.1128/aac.01671.
PubMed Abstract available

January 2025

FORRISTER NM, McCarty TP, Pappas PG
New Perspectives on Antimicrobial Agents: Rezafungin.
Antimicrob Agents Chemother. 2025;69:e0064623.
PubMed Abstract available

LI T, Zhu Y, Xiang G, Xu Z, et al
Adaptive evolution of extensive drug resistance and persistence in epidemic ST11 KPC-producing Klebsiella pneumoniae during antimicrobial chemotherapy.
Antimicrob Agents Chemother. 2025;69:e0123524.
PubMed Abstract available

KOENIG C, Monogue ML, Shields RK, Sakon CM, et al
Cefiderocol pharmacokinetics during acute pulmonary exacerbations in hospitalized adult persons with cystic fibrosis.
Antimicrob Agents Chemother. 2025;69:e0153924.
PubMed Abstract available

HE Z, Huang Y, Li W, Zhang H, et al
Characterization and genomic analysis of the highly virulent Acinetobacter baumannii ST1791 strain dominating in Anhui, China.
Antimicrob Agents Chemother. 2025;69:e0126224.
PubMed Abstract available

MORITA D, Mukhopadhyay AK, Chowdhury G, Maruyama F, et al
Genomic epidemiology and genetic characteristics of clinical Campylobacter species cocirculating in West Bengal, India, 2019, using whole genome analysis.
Antimicrob Agents Chemother. 2025;69:e0110824.
PubMed Abstract available

WANG J, Liu X, Song Y, Liu Z, et al
LC-AMP-I1, a novel venom-derived antimicrobial peptide from the wolf spider Lycosa coelestis.
Antimicrob Agents Chemother. 2025;69:e0042424.
PubMed Abstract available

WIEDERHOLD NP, Patterson HP, Ferrer D, Garcia V, et al
Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity.
Antimicrob Agents Chemother. 2025;69:e0098824.
PubMed Abstract available

ZHU Q, Wijnants S, Feil R, Van Genechten W, et al
The stress-protectant molecule trehalose mediates fluconazole tolerance in Candida glabrata.
Antimicrob Agents Chemother. 2025 Jan 24:e0134924. doi: 10.1128/aac.01349.
PubMed Abstract available

VOGENSEN VB, Singh S, Allende CJ, Engelthaler DM, et al
Fluoroquinolones and rifampin combination in the backdrop of heteroresistant tuberculosis.
Antimicrob Agents Chemother. 2025 Jan 16:e0108424. doi: 10.1128/aac.01084.
PubMed Abstract available

SADER HS, Smart JI, Mendes RE, Castanheira M, et al
Ceftobiprole activity against multidrug-resistant Staphylococcus aureus clinical isolates collected in the United States from 2016 through 2022.
Antimicrob Agents Chemother. 2025 Jan 13:e0140224. doi: 10.1128/aac.01402.
PubMed Abstract available

December 2024

JEHANNE Q, Benejat L, Ducournau A, Aptel J, et al
Increasing rates of erm(B) and erm(N) in human Campylobacter coli and Campylobacter jejuni erythromycin-resistant isolates between 2018 and 2023 in France.
Antimicrob Agents Chemother. 2024 Dec 31:e0166824. doi: 10.1128/aac.01668.
PubMed Abstract available

OLLINGER TL, Zarnowski R, Parker JE, Kelly SL, et al
Genetic interaction analysis of Candida glabrata transcription factors CST6 and UPC2A in the regulation of respiration and fluconazole susceptibility.
Antimicrob Agents Chemother. 2024 Dec 23:e0129424. doi: 10.1128/aac.01294.
PubMed Abstract available

ZAGALIOTIS P, Michalik-Provasek J, Mavridou E, Naing E, et al
Bacteriophage treatment is effective against carbapenem-resistant Klebsiella pneumoniae (KPC) in a neutropenic murine model of gastrointestinal translocation and renal infection.
Antimicrob Agents Chemother. 2024 Dec 20:e0091924. doi: 10.1128/aac.00919.
PubMed Abstract available

GHATBALE P, Sah GP, Dunham S, Khong E, et al
In vitro resensitization of multidrug-resistant clinical isolates of Enterococcus faecium and E. faecalis through phage-antibiotic synergy.
Antimicrob Agents Chemother. 2024 Dec 19:e0074024. doi: 10.1128/aac.00740.
PubMed Abstract available

HIRAYAMA T, Miyazaki T, Tanaka R, Kitahori N, et al
TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1 expression.
Antimicrob Agents Chemother. 2024 Dec 18:e0150824. doi: 10.1128/aac.01508.
PubMed Abstract available

HEINE HS, Purcell BK, Duncan C, Miller L, et al
Evaluation of a potent LpxC inhibitor for post-exposure prophylaxis treatment of antibiotic-resistant Burkholderia pseudomallei in a murine infection model.
Antimicrob Agents Chemother. 2024 Dec 13:e0129524. doi: 10.1128/aac.01295.
PubMed Abstract available

BLANCO-MARTIN T, Gonzalez-Pinto L, Aja-Macaya P, Rodriguez-Pallares S, et al
Mutant prevention concentrations, in vitro resistance evolution dynamics, and mechanisms of resistance to imipenem and imipenem/relebactam in carbapenem-susceptible Klebsiella pneumoniae isolates showing ceftazidime/avibactam resistance.
Antimicrob Agents Chemother. 2024;68:e0112024.
PubMed Abstract available

LE TM, Eubank TA, McKelvey AM, Cao X, et al
Fidaxomicin resistance in Clostridioides difficile: a systematic review and predictive modeling with RNA polymerase binding sites.
Antimicrob Agents Chemother. 2024;68:e0120624.
PubMed Abstract available

ZHAO H, Hu Y, Nie D, Li N, et al
A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity.
Antimicrob Agents Chemother. 2024;68:e0056524.
PubMed Abstract available

RODRIGUEZ-PALLARES S, Blanco-Martin T, Lence E, Aja-Macaya P, et al
In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC beta-lactamase in Klebsiella aerogenes.
Antimicrob Agents Chemother. 2024;68:e0130724.
PubMed Abstract available

XU T, Wu W, Huang L, Liu B, et al
Novel plasmid-mediated CMY variant (CMY-192) conferring ceftazidime-avibactam resistance in multidrug-resistant Escherichia coli.
Antimicrob Agents Chemother. 2024;68:e0090624.
PubMed Abstract available

WANG L, Li Y, Xiu L, Hu L, et al
Multigeographic clinical assessment of a molecular diagnostic assay for detection of key codons to predict decreased susceptibility or resistance to cephalosporins in Neisseria gonorrhoeae.
Antimicrob Agents Chemother. 2024;68:e0116524.
PubMed Abstract available

YANG C, Wang L, Lv J, Wen Y, et al
Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2024;68:e0101924.
PubMed Abstract available

ARAGAW WW, Gebresilase TT, Negatu DA, Dartois V, et al
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus.
Antimicrob Agents Chemother. 2024;68:e0105124.
PubMed Abstract available

MELENDEZ JH, Edwards VL, Muniz Tirado A, Hardick J, et al
Local emergence and global evolution of Neisseria gonorrhoeae with high-level resistance to azithromycin.
Antimicrob Agents Chemother. 2024;68:e0092724.
PubMed Abstract available

November 2024

BUSH NG, Diez-Santos I, Sankara Krishna P, Clavijo B, et al
Insights into antibiotic resistance promoted by quinolone exposure.
Antimicrob Agents Chemother. 2024 Nov 26:e0099724. doi: 10.1128/aac.00997.
PubMed Abstract available

JIA H, Li X, Zhuang Y, Wu Y, et al
Neural network-based predictions of antimicrobial resistance phenotypes in multidrug-resistant Acinetobacter baumannii from whole genome sequencing and gene expression.
Antimicrob Agents Chemother. 2024 Nov 14:e0144624. doi: 10.1128/aac.01446.
PubMed Abstract available

HERRERA C, Gomis-Font MA, Lopez-Causape C, Diez-Aguilar M, et al
Mechanisms leading to in vivo ceftazidime/avibactam resistance development during treatment of GES-5-producing Pseudomonas aeruginosa infections.
Antimicrob Agents Chemother. 2024;68:e0116424.
PubMed Abstract available

BLANCO-MARTIN T, Lopez-Hernandez I, Aracil B, Gonzalez-Pinto L, et al
Assessment of the activity and mechanisms of resistance to cefiderocol and combinations of beta-lactams and the novel beta-lactamase inhibitors avibactam, taniborbactam, zidebactam, nacubactam, xeruborbactam, and ANT3310 in emerging double-carbapenema
Antimicrob Agents Chemother. 2024;68:e0092424.
PubMed Abstract available

SATTLER J, Ernst CM, Zweigner J, Hamprecht A, et al
High frequency of acquired virulence factors in carbapenemase-producing Klebsiella pneumoniae isolates from a large German university hospital, 2013-2021.
Antimicrob Agents Chemother. 2024;68:e0060224.
PubMed Abstract available

PUUMALA E, Nabeela S, Thornburg CC, Grkovic T, et al
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy.
Antimicrob Agents Chemother. 2024;68:e0119424.
PubMed Abstract available

SEREME Y, Faury H, Gravrand V, Ageron E, et al
Molecular insights into the evolutionary trajectory of a Klebsiella aerogenes clinical isolate with a complex trade-off between resistance and virulence.
Antimicrob Agents Chemother. 2024;68:e0103624.
PubMed Abstract available

MARTIN MJ, Luo TL, Kovalchuk V, Kondratiuk V, et al
Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla(NDM-5) and bla(KPC-3) from foreign fighters evacuated from Ukraine.
Antimicrob Agents Chemother. 2024;68:e0109024.
PubMed Abstract available

OKE MT, Martz K, Mocanita M, Knezevic S, et al
Analysis of Acinetobacter P-type type IV secretion system-encoding plasmid diversity uncovers extensive secretion system conservation and diverse antibiotic resistance determinants.
Antimicrob Agents Chemother. 2024 Nov 4:e0103824. doi: 10.1128/aac.01038.
PubMed Abstract available

October 2024

KON H, Lurie-Weinberger MN, Bechor M, Temkin E, et al
bla(GES)-producing ST654 comprises a quarter of all carbapenem-resistant Pseudomonas aeruginosa in blood isolates from 15 hospitals.
Antimicrob Agents Chemother. 2024 Oct 31:e0096524. doi: 10.1128/aac.00965.
PubMed Abstract available

LI J, Brandalise D, Coste AT, Sanglard D, et al
Exploration of novel mechanisms of azole resistance in Candida auris.
Antimicrob Agents Chemother. 2024 Oct 31:e0126524. doi: 10.1128/aac.01265.
PubMed Abstract available

MA Z, Zeng W, Liu H, Chen H, et al
Characterization of novel sequence type 12531 and O8:H7 serotype carbapenem-resistant Escherichia coli with strong swimming and intestinal epithelial cell barrier migration abilities.
Antimicrob Agents Chemother. 2024 Oct 23:e0080524. doi: 10.1128/aac.00805.
PubMed Abstract available

ZARSKE M, Werckenthin C, Golz JC, Stingl K, et al
The point mutation A1387G in the 16S rRNA gene confers aminoglycoside resistance in Campylobacter jejuni and Campylobacter coli.
Antimicrob Agents Chemother. 2024 Oct 15:e0083324. doi: 10.1128/aac.00833.
PubMed Abstract available

KENT AG, Spicer LM, Campbell D, Breaker E, et al
Sentinel Surveillance reveals phylogenetic diversity and detection of linear plasmids harboring vanA and optrA among enterococci collected in the United States.
Antimicrob Agents Chemother. 2024 Oct 15:e0059124. doi: 10.1128/aac.00591.
PubMed Abstract available

HONG H, Fan L, Shi W, Zhu Y, et al
Overexpression of beta-lactamase genes (bla(KPC,) bla(SHV)) and novel CirA deficiencies contribute to decreased cefiderocol susceptibility in carbapenem-resistant Klebsiella pneumoniae before its approval in China.
Antimicrob Agents Chemother. 2024 Oct 10:e0075424. doi: 10.1128/aac.00754.
PubMed Abstract available

SALAMA EA, Elgammal Y, Utturkar SM, Lanman NA, et al
Overcoming amphotericin B resistance in Candida auris using the antiemetic drug rolapitant.
Antimicrob Agents Chemother. 2024 Oct 10:e0055624. doi: 10.1128/aac.00556.
PubMed Abstract available

KAUR JN, Klem JF, Liu Y, Boissonneault KR, et al
Maximally precise combinations to overcome metallo-beta-lactamase-producing Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2024;68:e0077024.
PubMed Abstract available

LI H, Oliver A, Shields RK, Kamat S, et al
Molecular characterization of clinically isolated Pseudomonas aeruginosa with varying resistance to ceftazidime-avibactam and ceftolozane-tazobactam collected as a part of the ATLAS global surveillance program from 2020 to 2021.
Antimicrob Agents Chemother. 2024;68:e0067024.
PubMed Abstract available

STURARO MC, Damaceno NdS, Faccin ID, Silva ON, et al
Synergistic antimicrobial combination of third-generation cephalosporins and polymyxin B against carbapenem-polymyxin-resistant Klebsiella pneumoniae: an in vitro and in vivo analysis.
Antimicrob Agents Chemother. 2024;68:e0093024.
PubMed Abstract available

HUANG H, Yang H, Feng S, Zhang X, et al
High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in Helicobacter pylori.
Antimicrob Agents Chemother. 2024;68:e0058724.
PubMed Abstract available

RUBIO J, Yan J, Miller S, Cheng J, et al
Polymyxins retain in vitro activity and in vivo efficacy against "resistant" Acinetobacter baumannii strains when tested in physiological conditions.
Antimicrob Agents Chemother. 2024;68:e0072524.
PubMed Abstract available

SINGH V, Nandanwar H
IMT-P8 potentiates Gram-positive specific antibiotics in intrinsically resistant Gram-negative bacteria.
Antimicrob Agents Chemother. 2024;68:e0075324.
PubMed Abstract available

HAREZA DA, Cosgrove SE, Bonomo RA, Dzintars K, et al
Clinical outcomes and emergence of resistance of Pseudomonas aeruginosa infections treated with ceftolozane-tazobactam versus ceftazidime-avibactam.
Antimicrob Agents Chemother. 2024;68:e0090724.
PubMed Abstract available

WOOD GE, Lee JW, Peramuna T, Wendt KL, et al
The fungal natural product fusidic acid demonstrates potent activity against Mycoplasma genitalium.
Antimicrob Agents Chemother. 2024;68:e0100624.
PubMed Abstract available

GAONA M, Corral J, Campoy S, Barbe J, et al
The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii.
Antimicrob Agents Chemother. 2024;68:e0071224.
PubMed Abstract available

KOLLER BH, Jania LA, Li H, Barker WT, et al
Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination.
Antimicrob Agents Chemother. 2024;68:e0067124.
PubMed Abstract available

ALLAIN M, Morel-Journel T, Condamine B, Gibeaux B, et al
IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in Escherichia coli.
Antimicrob Agents Chemother. 2024;68:e0055424.
PubMed Abstract available

DUBEY V, Farrington N, Harper N, Johnson A, et al
Acinetobacter baumannii transformants expressing oxacillinases and metallo-beta-lactamases that confer resistance to meropenem: new tools for anti-Acinetobacter drug development and AMR preparedness.
Antimicrob Agents Chemother. 2024;68:e0022224.
PubMed Abstract available

XU J-Y, Dong H-h, Liao L-j, Yang S-x, et al
Deoxyshikonin: a promising lead drug grass against drug resistance or sensitivity to Helicobacter pylori in an acidic environment.
Antimicrob Agents Chemother. 2024;68:e0095924.
PubMed Abstract available

YASMIN M, Marshall SH, Chen L, Rhoads DD, et al
A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2024;68:e0020824.
PubMed Abstract available

FUKUSHIMA K, Matsumoto Y, Abe Y, Hashimoto K, et al
Variability of macrolide-resistant profile in Mycobacterium avium complex pulmonary disease.
Antimicrob Agents Chemother. 2024 Oct 8:e0121324. doi: 10.1128/aac.01213.
PubMed Abstract available

September 2024

RHODES J, Jacobs J, Dennis EK, Manjari SR, et al
What makes Candida auris pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugs.
Antimicrob Agents Chemother. 2024 Sep 19:e0091124. doi: 10.1128/aac.00911.
PubMed Abstract available

CASTANHEIRA M, Deshpande LM, Rhomberg PR, Carvalhaes CG, et al
Recent increase in Candida auris frequency in the SENTRY surveillance program: antifungal activity and genotypic characterization.
Antimicrob Agents Chemother. 2024 Sep 12:e0057024. doi: 10.1128/aac.00570.
PubMed Abstract available

LE RUN E, Tettelin H, Holland SM, Zelazny AM, et al
Evolution toward extremely high imipenem resistance in Mycobacterium abscessus outbreak strains.
Antimicrob Agents Chemother. 2024 Sep 10:e0067324. doi: 10.1128/aac.00673.
PubMed Abstract available

KOMORI K, Aoki K, Harada S, Ishii Y, et al
Plasmid-mediated acquisition and chromosomal integration of bla(CTX-M-14) in a subclade of Escherichia coli ST131-H30 clade C1.
Antimicrob Agents Chemother. 2024;68:e0081724.
PubMed Abstract available

XUE J, Li S, Wang L, Zhao Y, et al
Enhanced fatty acid biosynthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori.
Antimicrob Agents Chemother. 2024;68:e0085024.
PubMed Abstract available

August 2024

MARTINI MC, Alonso MN, Cafiero JH, Xiao J, et al
Loss of glycerol catabolism confers carbon-source-dependent artemisinin resistance in Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 2024 Aug 28:e0064524. doi: 10.1128/aac.00645.
PubMed Abstract available

TIAN P, Li Q-Q, Guo M-J, Zhu Y-Z, et al
Zidovudine in synergistic combination with nitrofurantoin or omadacycline: in vitro and in murine urinary tract or lung infection evaluation against multidrug-resistant Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2024 Aug 28:e0034424. doi: 10.1128/aac.00344.
PubMed Abstract available

TAO L, Dahlquist A, Harris H, Jacobs E, et al
Multicenter evaluation of activity of aztreonam in combination with avibactam, relebactam, and vaborbactam against metallo-beta-lactamase-producing carbapenem-resistant gram-negative bacilli.
Antimicrob Agents Chemother. 2024 Aug 19:e0069324. doi: 10.1128/aac.00693.
PubMed Abstract available

HEINE HS, Drusano G, Purcell BK, Anastasiou D, et al
Omadacycline is active in vitro and in vivo against ciprofloxacin-resistant Bacillus anthracis.
Antimicrob Agents Chemother. 2024 Aug 12:e0059524. doi: 10.1128/aac.00595.
PubMed Abstract available

JACOBS MR, Abdelhamed AM, Good CE, Mack AR, et al
ARGONAUT-III and -V: susceptibility of carbapenem-resistant Klebsiella pneumoniae and multidrug-resistant Pseudomonas aeruginosa to the bicyclic boronate beta-lactamase inhibitor taniborbactam combined with cefepime.
Antimicrob Agents Chemother. 2024 Aug 12:e0075124. doi: 10.1128/aac.00751.
PubMed Abstract available

ROTONDO CM, Wright GD
Efficacy of aspergillomarasmine A/meropenem combinations with and without avibactam against bacterial strains producing multiple beta-lactamases.
Antimicrob Agents Chemother. 2024 Aug 12:e0027224. doi: 10.1128/aac.00272.
PubMed Abstract available

EISHA S, Morris AJ, Martin I, Yau YCW, et al
Effect of L-arginine on cystic fibrosis Pseudomonas aeruginosa biofilms.
Antimicrob Agents Chemother. 2024;68:e0033624.
PubMed Abstract available

EGGE SL, Rizvi SA, Simar SR, Alcalde M, et al
Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin.
Antimicrob Agents Chemother. 2024;68:e0012724.
PubMed Abstract available

PONTA G, Morena V, Strano M, Molteni C, et al
Safety of rezafungin as a long-term treatment option in two patients with complicated fungal infections: two cases from Lecco Hospital (Italy).
Antimicrob Agents Chemother. 2024;68:e0075024.
PubMed Abstract available

July 2024

NELSON ME, Little JL, Kristich CJ
Pbp4 provides transpeptidase activity to the FtsW-PbpB peptidoglycan synthase to drive cephalosporin resistance in Enterococcus faecalis.
Antimicrob Agents Chemother. 2024 Jul 26:e0055524. doi: 10.1128/aac.00555.
PubMed Abstract available

ADELMAN MW, Andes DR
Case Commentary: Extending our therapeutic range against multidrug-resistant Candida.
Antimicrob Agents Chemother. 2024 Jul 22:e0084724. doi: 10.1128/aac.00847.
PubMed Abstract available

TRUONG-BOLDUC QC, Wang Y, Lawton BG, Brown Harding H, et al
Phenazine-1 carboxylic acid of Pseudomonas aeruginosa induces the expression of Staphylococcus aureus Tet38 MDR efflux pump and mediates resistance to phenazines and antibiotics.
Antimicrob Agents Chemother. 2024 Jul 19:e0063624. doi: 10.1128/aac.00636.
PubMed Abstract available

GIGANTE V, Alm RA, Melchiorri D, Rocke T, et al
Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps.
Antimicrob Agents Chemother. 2024 Jul 15:e0053524. doi: 10.1128/aac.00535.
PubMed Abstract available

STRAHILEVITZ J, Motro Y, Temper V, Merezhko D, et al
In vivo selection of carbapenem resistance during persistent Klebsiella pneumoniae sequence type 395 bloodstream infection due to OmpK36 deletion.
Antimicrob Agents Chemother. 2024 Jul 11:e0066324. doi: 10.1128/aac.00663.
PubMed Abstract available

DULYAYANGKUL P, Sealey JE, Lee WWY, Satapoomin N, et al
Improving nitrofurantoin resistance prediction in Escherichia coli from whole-genome sequence by integrating NfsA/B enzyme assays.
Antimicrob Agents Chemother. 2024;68:e0024224.
PubMed Abstract available

BEREDAKI M-I, Arendrup MC, Pournaras S, Meletiadis J, et al
Comparative pharmacodynamics and dose optimization of liposomal amphotericin B against Candida species in an in vitro pharmacokinetic/pharmacodynamic model.
Antimicrob Agents Chemother. 2024 Jul 3:e0022524. doi: 10.1128/aac.00225.
PubMed Abstract available

June 2024

MA Y, Pirolo M, Jana B, Mebus VH, et al
The intrinsic macrolide resistome of Escherichia coli.
Antimicrob Agents Chemother. 2024 Jun 28:e0045224. doi: 10.1128/aac.00452.
PubMed Abstract available

KURTZHALS ML, Norman A, Svensson E, Lillebaek T, et al
Applying whole genome sequencing to predict phenotypic drug resistance in Mycobacterium tuberculosis: leveraging 20 years of nationwide data from Denmark.
Antimicrob Agents Chemother. 2024 Jun 21:e0043024. doi: 10.1128/aac.00430.
PubMed Abstract available

PLUMET L, Magnan C, Ahmad-Mansour N, Sotto A, et al
The zebrafish embryo model: unveiling its potential for investigating phage therapy against methicillin-resistant Staphylococcus aureus infection.
Antimicrob Agents Chemother. 2024 Jun 20:e0056124. doi: 10.1128/aac.00561.
PubMed Abstract available

SON JE, Park SH, Choi U, Lee C-R, et al
Lytic transglycosylase repertoire diversity enables intrinsic antibiotic resistance and daughter cell separation in Escherichia coli under acidic stress.
Antimicrob Agents Chemother. 2024 Jun 17:e0037224. doi: 10.1128/aac.00372.
PubMed Abstract available

DIAMOND TL, Goh SL, Ngo W, Rodriguez S, et al
No antagonism or cross-resistance and a high barrier to the emergence of resistance in vitro for the combination of islatravir and lenacapavir.
Antimicrob Agents Chemother. 2024 Jun 12:e0033424. doi: 10.1128/aac.00334.
PubMed Abstract available

PETERSIEL N, Giulieri S, Daniel DS, Fan S-H, et al
Genomic investigation and clinical correlates of the in vitro beta-lactam: NaHCO(3) responsiveness phenotype among methicillin-resistant Staphylococcus aureus isolates from a randomized clinical trial.
Antimicrob Agents Chemother. 2024 Jun 5:e0021824. doi: 10.1128/aac.00218.
PubMed Abstract available

MINUK LM, Brode SK, Mehrabi M, Sharma MK, et al
Phenotypic amikacin resistance may not indicate poor response to amikacin in Mycobacterium avium complex pulmonary disease.
Antimicrob Agents Chemother. 2024;68:e0008424.
PubMed Abstract available

May 2024

HUANG E, Thompson RN, Moon SH, Keck JM, et al
Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence ISAba36 in the siderophore receptor pirA.
Antimicrob Agents Chemother. 2024 May 29:e0029024. doi: 10.1128/aac.00290.
PubMed Abstract available

ANOY MMI, Kim W-J, Gelston S, Fleming D, et al
Evaluation of treatment of methicillin-resistant Staphylococcus aureus biofilms with intermittent electrochemically generated H(2)O(2) or HOCl.
Antimicrob Agents Chemother. 2024 May 21:e0172223. doi: 10.1128/aac.01722.
PubMed Abstract available

LUO J, Liu M, Ai W, Zheng X, et al
Synergy of lytic phage pB23 and meropenem combination against carbapenem-resistant Acinetobacter baumannii.
Antimicrob Agents Chemother. 2024 May 14:e0044824. doi: 10.1128/aac.00448.
PubMed Abstract available

BERGIN S, Doorley LA, Rybak JM, Wolfe KH, et al
Analysis of clinical Candida parapsilosis isolates reveals copy number variation in key fluconazole resistance genes.
Antimicrob Agents Chemother. 2024 May 7:e0161923. doi: 10.1128/aac.01619.
PubMed Abstract available

TAKEMOTO K, Nakayama R, Fujimoto K, Suzuki Y, et al
In vitro and in vivo activities of KSP-1007, a broad-spectrum inhibitor of serine- and metallo-beta-lactamases, in combination with meropenem against carbapenem-resistant Gram-negative bacteria.
Antimicrob Agents Chemother. 2024 May 6:e0160223. doi: 10.1128/aac.01602.
PubMed Abstract available

SCHALKWIJK HH, Shewakramani NR, Das K, Andrei G, et al
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1.
Antimicrob Agents Chemother. 2024;68:e0011024.
PubMed Abstract available

VEGA AD, DeRonde K, Jimenez A, Piazza M, et al
Difficult-to-treat (DTR) Pseudomonas aeruginosa harboring Verona-Integron metallo-beta-lactamase (bla(VIM)): infection management and molecular analysis.
Antimicrob Agents Chemother. 2024;68:e0147423.
PubMed Abstract available

MILLER AA, Moussa SH, McLeod SM
Characterization of Acinetobacter baumannii-calcoaceticus complex isolates and microbiological outcome for patients treated with sulbactam-durlobactam in a phase 3 trial (ATTACK).
Antimicrob Agents Chemother. 2024;68:e0169823.
PubMed Abstract available

ISHII M, Yamada T, Ishikawa K, Ichinose K, et al
The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum.
Antimicrob Agents Chemother. 2024;68:e0160923.
PubMed Abstract available

GHOSH S, Orman MA
Exploring the links between SOS response, mutagenesis, and resistance during the recovery period.
Antimicrob Agents Chemother. 2024;68:e0146223.
PubMed Abstract available

CASTANHEIRA M, Kimbrough JH, Lindley J, Doyle TB, et al
In vitro development of resistance against antipseudomonal agents: comparison of novel beta-lactam/beta-lactamase inhibitor combinations and other beta-lactam agents.
Antimicrob Agents Chemother. 2024;68:e0136323.
PubMed Abstract available

XIA L, Li Y, Wang Y, Zhou H, et al
Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin.
Antimicrob Agents Chemother. 2024;68:e0011824.
PubMed Abstract available

SUZUKI D, Sakurai A, Wakuda M, Suzuki M, et al
Clinical and genomic characteristics of IMP-producing Enterobacter cloacae complex and Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2024;68:e0167223.
PubMed Abstract available

NIELSEN TK, Petersen IB, Xu L, Barbuti MD, et al
The Spx stress regulator confers high-level beta-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2024 May 1:e0033524. doi: 10.1128/aac.00335.
PubMed Abstract available

April 2024

PETRAITIS V, Petraitiene R, Kavaliauskas P, Naing E, et al
Development of rabbit models of ventilator-associated bacterial pneumonia produced by carbapenem-resistant Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2024 Apr 30:e0020524. doi: 10.1128/aac.00205.
PubMed Abstract available

SHAFER WM, Conn GL
Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level.
Antimicrob Agents Chemother. 2024 Apr 19:e0024424. doi: 10.1128/aac.00244.
PubMed Abstract available

LYU Z, Ling Y, van Hoof A, Ling J, et al
Inactivation of the ribosome assembly factor RimP causes streptomycin resistance and impairs motility in Salmonella.
Antimicrob Agents Chemother. 2024 Apr 17:e0000224. doi: 10.1128/aac.00002.
PubMed Abstract available

HARTUIS S, Ourliac-Garnier I, Robert E, Albassier M, et al
Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis.
Antimicrob Agents Chemother. 2024 Apr 16:e0002224. doi: 10.1128/aac.00022.
PubMed Abstract available

LOSSOUARN J, Beurrier E, Bouteau A, Moncaut E, et al
The virtue of training: extending phage host spectra against vancomycin-resistant Enterococcus faecium strains using the Appelmans method.
Antimicrob Agents Chemother. 2024 Apr 9:e0143923. doi: 10.1128/aac.01439.
PubMed Abstract available

TENG T, Chen S, Huo F, Jia J, et al
Efflux pump effects on levofloxacin resistance in Mycobacterium abscessus.
Antimicrob Agents Chemother. 2024 Apr 4:e0134823. doi: 10.1128/aac.01348.
PubMed Abstract available

SHANG Y, Zhang Y, Wang R, Peng Y, et al
Deciphering the molecular and functional basis of TMexCD1: the plasmid-encoded efflux pump of resistance-nodulation-division superfamily.
Antimicrob Agents Chemother. 2024;68:e0167823.
PubMed Abstract available

RIBEIRO DOS SANTOS A, Gade L, Misas E, Litvintseva AP, et al
Bimodal distribution of azole susceptibility in Sporothrix brasiliensis isolates in Brazil.
Antimicrob Agents Chemother. 2024;68:e0162023.
PubMed Abstract available

TAIT JR, Anderson D, Nation RL, Creek DJ, et al
Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2024;68:e0108123.
PubMed Abstract available

YANO H, Hayashi W, Kawakami S, Aoki S, et al
Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan.
Antimicrob Agents Chemother. 2024 Apr 2:e0166923. doi: 10.1128/aac.01669.
PubMed Abstract available

March 2024

MAIA AR, Cezard A, Fouquenet D, Vasseur V, et al
Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2024 Mar 25:e0136123. doi: 10.1128/aac.01361.
PubMed Abstract available

SEGAWA T, Masuda K, Hisatsune J, Ishida-Kuroki K, et al
Genomic analysis of inter-hospital transmission of vancomycin-resistant Enterococcus faecium sequence type 80 isolated during an outbreak in Hiroshima, Japan.
Antimicrob Agents Chemother. 2024 Mar 20:e0171623. doi: 10.1128/aac.01716.
PubMed Abstract available

SUN L, Zhuang H, Chen M, Chen Y, et al
Vancomycin heteroresistance caused by unstable tandem amplifications of the vanM gene cluster on linear conjugative plasmids in a clinical Enterococcus faecium.
Antimicrob Agents Chemother. 2024 Mar 20:e0115923. doi: 10.1128/aac.01159.
PubMed Abstract available

LI W, He Z, Di W, Xu W, et al
Transposition mechanism of ISApl1-the determinant of colistin resistance dissemination.
Antimicrob Agents Chemother. 2024;68:e0123123.
PubMed Abstract available

ANDRE C, Van Camp AG, Ung L, Gilmore MS, et al
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
Antimicrob Agents Chemother. 2024;68:e0124723.
PubMed Abstract available

CARUSO L, Mellini M, Catalano Gonzaga O, Astegno A, et al
Hydrogen sulfide production does not affect antibiotic resistance in Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2024 Mar 6:e0007524. doi: 10.1128/aac.00075.
PubMed Abstract available

February 2024

ZHANG M, Yang B, Shi J, Wang Z, et al
Host defense peptides mitigate the spread of antibiotic resistance in physiologically relevant condition.
Antimicrob Agents Chemother. 2024 Feb 28:e0126123. doi: 10.1128/aac.01261.
PubMed Abstract available

MULATO A, Lansdon E, Aoyama R, Voigt J, et al
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother. 2024 Feb 21:e0137323. doi: 10.1128/aac.01373.
PubMed Abstract available

FREIBERG JA, Tao L, Manuel C, Mike LA, et al
A multi-species outbreak of VIM-producing carbapenem-resistant bacteria in a burn unit and subsequent investigation of rapid development of cefiderocol resistance.
Antimicrob Agents Chemother. 2024 Feb 20:e0150723. doi: 10.1128/aac.01507.
PubMed Abstract available

BASSERES E, Eubank TA, Begum K, Alam MJ, et al
Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of Clostridioides difficile.
Antimicrob Agents Chemother. 2024 Feb 16:e0162123. doi: 10.1128/aac.01621.
PubMed Abstract available

ERSOY SC, Proctor RA, Rose WE, Abdelhady W, et al
Sensitizing methicillin-resistant Staphylococcus aureus (MRSA) to cefuroxime: the synergic effect of bicarbonate and the wall teichoic acid inhibitor ticlopidine.
Antimicrob Agents Chemother. 2024 Feb 13:e0162723. doi: 10.1128/aac.01627.
PubMed Abstract available

PITOUT JDD, Peirano G, Matsumura Y, DeVinney R, et al
Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance.
Antimicrob Agents Chemother. 2024;68:e0133923.
PubMed Abstract available

DRUSIN SI, Le Terrier C, Poirel L, Bonomo RA, et al
Structural basis of metallo-beta-lactamase resistance to taniborbactam.
Antimicrob Agents Chemother. 2024;68:e0116823.
PubMed Abstract available

January 2024

JIANG X, Li D, Sun Z, Lu Y, et al
Type I BREX system defends against antibiotic-resistant plasmids in Escherichia coli.
Antimicrob Agents Chemother. 2024 Jan 30:e0112823. doi: 10.1128/aac.01128.
PubMed Abstract available

IOVLEVA A, McElheny CL, Fowler EL, Cober E, et al
In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals.
Antimicrob Agents Chemother. 2024 Jan 30:e0125823. doi: 10.1128/aac.01258.
PubMed Abstract available

ZALACAIN M, Achard P, Llanos A, Morrissey I, et al
Meropenem-ANT3310, a unique beta-lactam-beta-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii.
Antimicrob Agents Chemother. 2024 Jan 30:e0112023. doi: 10.1128/aac.01120.
PubMed Abstract available

AXELL-HOUSE DB, Simar SR, Panesso D, Rincon S, et al
LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium.
Antimicrob Agents Chemother. 2024 Jan 30:e0106923. doi: 10.1128/aac.01069.
PubMed Abstract available

ALDEJOHANN AM, Menner C, Thielemann N, Martin R, et al
In vitro activity of ibrexafungerp against clinically relevant echinocandin-resistant Candida strains.
Antimicrob Agents Chemother. 2024 Jan 11:e0132423. doi: 10.1128/aac.01324.
PubMed Abstract available

TERAN N, Egge SL, Phe K, Baptista RP, et al
The emergence of cefiderocol resistance in Pseudomonas aeruginosa from a heteroresistant isolate during prolonged therapy.
Antimicrob Agents Chemother. 2024;68:e0100923.
PubMed Abstract available

CHEN T, Yao J, Quan K, Xu J, et al
Repurposing a human acetyl-CoA carboxylase inhibitor firsocostat to treat fungal candidiasis alone and in combination.
Antimicrob Agents Chemother. 2024;68:e0113123.
PubMed Abstract available

December 2023

TAKEMURA M, Nakamura R, Ota M, Nakai R, et al
In vitro and in vivo activity of cefiderocol against Achromobacter spp. and Burkholderia cepacia complex, including carbapenem-non-susceptible isolates.
Antimicrob Agents Chemother. 2023;67:e0034623.
PubMed Abstract available

November 2023

ZHAO J, Pu D, Li Z, Liu X, et al
In vitro activity of cefiderocol, a siderophore cephalosporin, against carbapenem-resistant hypervirulent Klebsiella pneumoniae in China.
Antimicrob Agents Chemother. 2023 Nov 28:e0073523. doi: 10.1128/aac.00735.
PubMed Abstract available

JIAO F, Bao Y, Li M, Zhang Y, et al
Unraveling the mechanism of ceftaroline-induced allosteric regulation in penicillin-binding protein 2a: insights for novel antibiotic development against methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother. 2023 Nov 16:e0089523. doi: 10.1128/aac.00895.
PubMed Abstract available

DIAZ-GARCIA J, Machado M, Alcala L, Reigadas E, et al
Trends in antifungal resistance in Candida from a multicenter study conducted in Madrid (CANDIMAD study): fluconazole-resistant C. parapsilosis spreading has gained traction in 2022.
Antimicrob Agents Chemother. 2023;67:e0098623.
PubMed Abstract available

BOSCH A, Macha ME, Ren Q, Kohler P, et al
Resistance development in Escherichia coli to delafloxacin at pHs 6.0 and 7.3 compared to ciprofloxacin.
Antimicrob Agents Chemother. 2023;67:e0162522.
PubMed Abstract available

SCHILDKRAUT JA, Raaijmakers J, Aarnoutse R, Hoefsloot W, et al
The role of rifampicin within the treatment of Mycobacterium avium pulmonary disease.
Antimicrob Agents Chemother. 2023;67:e0087423.
PubMed Abstract available

YAMADA T, Maeda M, Nagai H, Salamin K, et al
Two different types of tandem sequences mediate the overexpression of TinCYP51B in azole-resistant Trichophyton indotineae.
Antimicrob Agents Chemother. 2023;67:e0093323.
PubMed Abstract available

October 2023

JIANG S, Chen M, Zhang J, Ba X, et al
Profiling daptomycin resistance among diverse methicillin-resistant Staphylococcus aureus lineages in China.
Antimicrob Agents Chemother. 2023 Oct 30:e0056323. doi: 10.1128/aac.00563.
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ZHANG S-P, Ye Y-P, Hou J, Ye Z-R, et al
Antitoxin MqsA decreases antibiotic susceptibility through the global regulator AgtR in Pseudomonas fluorescens.
Antimicrob Agents Chemother. 2023 Oct 25:e0081223. doi: 10.1128/aac.00812.
PubMed Abstract available

TAKAHASHI H, Morita M, Kamiya H, Fukusumi M, et al
Emergence of ciprofloxacin- and penicillin-resistant Neisseria meningitidis isolates in Japan between 2003 and 2020 and its genetic features.
Antimicrob Agents Chemother. 2023 Oct 24:e0074423. doi: 10.1128/aac.00744.
PubMed Abstract available

LAU JZ, Kuo SH, Belo Y, Malach E, et al
Antibacterial efficacy of an ultra-short palmitoylated random peptide mixture in mouse models of infection by carbapenem-resistant Klebsiella pneumoniae.
Antimicrob Agents Chemother. 2023 Oct 11:e0057423. doi: 10.1128/aac.00574.
PubMed Abstract available

KUHBACHER A, Merschak P, Haas H, Liebl M, et al
The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus.
Antimicrob Agents Chemother. 2023 Oct 10:e0091823. doi: 10.1128/aac.00918.
PubMed Abstract available

LOMOVSKAYA O, Castanheira M, Lindley J, Rubio-Aparicio D, et al
In vitro potency of xeruborbactam in combination with multiple beta-lactam antibiotics in comparison with other beta-lactam/beta-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum beta-lactamase-producing Enterob
Antimicrob Agents Chemother. 2023 Oct 6:e0044023. doi: 10.1128/aac.00440.
PubMed Abstract available

September 2023

MIRON-OCAMPO A, Beattie SR, Guin S, Conway T, et al
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Antimicrob Agents Chemother. 2023 Sep 13:e0056723. doi: 10.1128/aac.00567.
PubMed Abstract available

PODOLL JD, Rosen E, Wang W, Gao Y, et al
A small-molecule membrane fluidizer re-sensitizes methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics.
Antimicrob Agents Chemother. 2023 Sep 8:e0005123. doi: 10.1128/aac.00051.
PubMed Abstract available

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