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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 75 articles:
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Single Articles


    May 2022
  1. NEWBURY A, Dawson B, Klumper U, Hesse E, et al
    Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks.
    Proc Natl Acad Sci U S A. 2022;119:e2118361119.
    PubMed     Abstract available


  2. LIAKOPOULOS A, Aulin LBS, Buffoni M, Fragkiskou E, et al
    Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.
    Proc Natl Acad Sci U S A. 2022;119:e2121768119.
    PubMed     Abstract available


    April 2022
  3. HERNANDO-AMADO S, Laborda P, Valverde JR, Martinez JL, et al
    Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness.
    Proc Natl Acad Sci U S A. 2022;119:e2109370119.
    PubMed     Abstract available


  4. LAUGHLIN ZT, Nandi S, Dey D, Zelinskaya N, et al
    50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
    Proc Natl Acad Sci U S A. 2022;119:e2120352119.
    PubMed     Abstract available


  5. GEORGE NL, Schilmiller AL, Orlando BJ
    Conformational snapshots of the bacitracin sensing and resistance transporter BceAB.
    Proc Natl Acad Sci U S A. 2022;119:e2123268119.
    PubMed     Abstract available


    March 2022
  6. ZHANG Q, Wang R, Wang M, Liu C, et al
    Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver.
    Proc Natl Acad Sci U S A. 2022;119:e2119417119.
    PubMed     Abstract available


    February 2022
  7. VASAN AK, Haloi N, Ulrich RJ, Metcalf ME, et al
    Role of internal loop dynamics in antibiotic permeability of outer membrane porins.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  8. KARITA Y, Limmer DT, Hallatschek O
    Scale-dependent tipping points of bacterial colonization resistance.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    November 2021
  9. MARTIN MJ, Corey BW, Sannio F, Hall LR, et al
    Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  10. REITHUBER E, Wixe T, Ludwig KC, Muller A, et al
    THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  11. KONIG G, Sokkar P, Pryk N, Heinrich S, et al
    Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021
  12. DAN L, Li Y, Chen S, Liu J, et al
    A rapidly reversible mutation generates subclonal genetic diversity and unstable drug resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  13. LI J, Sae Her A, Traaseth NJ
    Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  14. ADKINS-JABLONSKY SJ, Clark CM, Papoulis SE, Kuhl MD, et al
    Market forces determine the distribution of a leaky function in a simple microbial community.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021
  15. LIM J, Lee JJ, Lee SK, Kim S, et al
    Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  16. CHAHAL J, Gebert LFR, Camargo C, MacRae IJ, et al
    miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  17. OTTONI C, Boric D, Cheronet O, Sparacello V, et al
    Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  18. DIMITRIU T, Matthews AC, Buckling A
    Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    July 2021
  19. GRASS LM, Wollenhaupt J, Barthel T, Parfentev I, et al
    Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  20. ZHANG J, Zhao X, Cappiello JR, Yang Y, et al
    Identification of simple arylfluorosulfates as potent agents against resistant bacteria.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  21. ARAGAW WW, Lee BM, Yang X, Zimmerman MD, et al
    Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  22. QIAN X, Gunturu S, Sun W, Cole JR, et al
    Long-read sequencing revealed cooccurrence, host range, and potential mobility of antibiotic resistome in cow feces.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  23. CHE Y, Yang Y, Xu X, Brinda K, et al
    Reply to Shaw: Challenges for enrichment analysis of AMR gene-bearing plasmids.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


  24. SCHUBERT MG, Goodman DB, Wannier TM, Kaur D, et al
    High-throughput functional variant screens via in vivo production of single-stranded DNA.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  25. JO WK, Schadenhofer A, Habierski A, Kaiser FK, et al
    Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  26. ANGST DC, Tepekule B, Sun L, Bogos B, et al
    Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    February 2021
  27. HUEMER M, Mairpady Shambat S, Bergada-Pijuan J, Soderholm S, et al
    Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  28. CHE Y, Yang Y, Xu X, Brinda K, et al
    Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  29. CARD KJ, Thomas MD, Graves JL Jr, Barrick JE, et al
    Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  30. GIRGIS HS, DuPai CD, Lund J, Reeder J, et al
    Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  31. OLDENKAMP R, Schultsz C, Mancini E, Cappuccio A, et al
    Filling the gaps in the global prevalence map of clinical antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  32. AUNINS TR, Erickson KE, Chatterjee A
    Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coli.
    Proc Natl Acad Sci U S A. 2020;117:30699-30709.
    PubMed     Abstract available


    November 2020
  33. ZULAUF KE, Kirby JE
    Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach.
    Proc Natl Acad Sci U S A. 2020;117:29839-29850.
    PubMed     Abstract available


  34. OLESEN SW, Lipsitch M, Grad YH
    The role of "spillover" in antibiotic resistance.
    Proc Natl Acad Sci U S A. 2020;117:29063-29068.
    PubMed     Abstract available


  35. LILIC M, Chen J, Boyaci H, Braffman N, et al
    The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
    Proc Natl Acad Sci U S A. 2020 Nov 16. pii: 2013706117.
    PubMed     Abstract available


  36. FLEEMAN RM, Macias LA, Brodbelt JS, Davies BW, et al
    Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae.
    Proc Natl Acad Sci U S A. 2020;117:27620-27626.
    PubMed     Abstract available


    October 2020
  37. WOODS LC, Gorrell RJ, Taylor F, Connallon T, et al
    Horizontal gene transfer potentiates adaptation by reducing selective constraints on the spread of genetic variation.
    Proc Natl Acad Sci U S A. 2020;117:26868-26875.
    PubMed     Abstract available


  38. TOMLINSON JH, Kalverda AP, Calabrese AN
    Fusidic acid resistance through changes in the dynamics of the drug target.
    Proc Natl Acad Sci U S A. 2020;117:25523-25531.
    PubMed     Abstract available


  39. DAVID S, Cohen V, Reuter S, Sheppard AE, et al
    Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae.
    Proc Natl Acad Sci U S A. 2020;117:25043-25054.
    PubMed     Abstract available


    September 2020
  40. KOWALSKI CH, Morelli KA, Schultz D, Nadell CD, et al
    Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance.
    Proc Natl Acad Sci U S A. 2020;117:22473-22483.
    PubMed     Abstract available


    August 2020
  41. ZHANG C, Song W, Ma HR, Peng X, et al
    Temporal encoding of bacterial identity and traits in growth dynamics.
    Proc Natl Acad Sci U S A. 2020;117:20202-20210.
    PubMed     Abstract available


  42. VIEGAS J
    Profile of Paul E. Turner.
    Proc Natl Acad Sci U S A. 2020;117:18906-18908.
    PubMed    


  43. LAKSHMAIAH NARAYANA J, Mishra B, Lushnikova T, Wu Q, et al
    Two distinct amphipathic peptide antibiotics with systemic efficacy.
    Proc Natl Acad Sci U S A. 2020;117:19446-19454.
    PubMed     Abstract available


  44. ALEXANDER HK, MacLean RC
    Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells.
    Proc Natl Acad Sci U S A. 2020;117:19455-19464.
    PubMed     Abstract available


  45. MORENO-GAMEZ S, Kiviet DJ, Vulin C, Schlegel S, et al
    Wide lag time distributions break a trade-off between reproduction and survival in bacteria.
    Proc Natl Acad Sci U S A. 2020;117:18729-18736.
    PubMed     Abstract available


    July 2020
  46. MELNIKOV SV, Stevens DL, Fu X, Kwok HS, et al
    Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.
    Proc Natl Acad Sci U S A. 2020;117:17924-17931.
    PubMed     Abstract available


  47. GATO E, Vazquez-Ucha JC, Rumbo-Feal S, Alvarez-Fraga L, et al
    Kpi, a chaperone-usher pili system associated with the worldwide-disseminated high-risk clone Klebsiella pneumoniae ST-15.
    Proc Natl Acad Sci U S A. 2020;117:17249-17259.
    PubMed     Abstract available


  48. BOLLA JR, Howes AC, Fiorentino F, Robinson CV, et al
    Assembly and regulation of the chlorhexidine-specific efflux pump AceI.
    Proc Natl Acad Sci U S A. 2020;117:17011-17018.
    PubMed     Abstract available


  49. CHEN X, Chen J, Yan B, Zhang W, et al
    Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
    Proc Natl Acad Sci U S A. 2020;117:16324-16332.
    PubMed     Abstract available


  50. RODRIGUEZ-BELTRAN J, Sorum V, Toll-Riera M, de la Vega C, et al
    Genetic dominance governs the evolution and spread of mobile genetic elements in bacteria.
    Proc Natl Acad Sci U S A. 2020;117:15755-15762.
    PubMed     Abstract available


    May 2020
  51. BURMEISTER AR, Fortier A, Roush C, Lessing AJ, et al
    Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.
    Proc Natl Acad Sci U S A. 2020;117:11207-11216.
    PubMed     Abstract available


  52. YANG Y, Gupta K, Ekinci KL
    All-electrical monitoring of bacterial antibiotic susceptibility in a microfluidic device.
    Proc Natl Acad Sci U S A. 2020;117:10639-10644.
    PubMed     Abstract available


  53. CHILAMBI GS, Nordstrom HR, Evans DR, Ferrolino JA, et al
    Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients.
    Proc Natl Acad Sci U S A. 2020 May 11. pii: 1917130117.
    PubMed     Abstract available


    April 2020
  54. GUPTA S, Louis JM, Tycko R
    Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles.
    Proc Natl Acad Sci U S A. 2020 Apr 27. pii: 1917755117.
    PubMed     Abstract available


  55. GUSA A, Williams JD, Cho JE, Averette AF, et al
    Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro.
    Proc Natl Acad Sci U S A. 2020 Apr 17. pii: 2001451117.
    PubMed     Abstract available


  56. STARR CG, Ghimire J, Guha S, Hoffmann JP, et al
    Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria.
    Proc Natl Acad Sci U S A. 2020;117:8437-8448.
    PubMed     Abstract available


    March 2020
  57. JONES JC, Pascua PNQ, Fabrizio TP, Marathe BM, et al
    Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility.
    Proc Natl Acad Sci U S A. 2020 Mar 26. pii: 1916825117.
    PubMed     Abstract available


  58. TARAFDER AK, von Kugelgen A, Mellul AJ, Schulze U, et al
    Phage liquid crystalline droplets form occlusive sheaths that encapsulate and protect infectious rod-shaped bacteria.
    Proc Natl Acad Sci U S A. 2020;117:4724-4731.
    PubMed     Abstract available


  59. MCDANIEL CT, Panmanee W, Winsor GL, Gill E, et al
    AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.
    Proc Natl Acad Sci U S A. 2020;117:4921-4930.
    PubMed     Abstract available


  60. ZUO W, Wu Y
    Dynamic motility selection drives population segregation in a bacterial swarm.
    Proc Natl Acad Sci U S A. 2020;117:4693-4700.
    PubMed     Abstract available


    February 2020
  61. HINGLEY-WILSON SM, Ma N, Hu Y, Casey R, et al
    Loss of phenotypic inheritance associated with ydcI mutation leads to increased frequency of small, slow persisters in Escherichia coli.
    Proc Natl Acad Sci U S A. 2020;117:4152-4157.
    PubMed     Abstract available


  62. HUSEBY DL, Brandis G, Praski Alzrigat L, Hughes D, et al
    Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene.
    Proc Natl Acad Sci U S A. 2020;117:3185-3191.
    PubMed     Abstract available


    January 2020
  63. PENG H, Borg RE, Dow LP, Pruitt BL, et al
    Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages.
    Proc Natl Acad Sci U S A. 2020;117:1951-1961.
    PubMed     Abstract available


  64. BOWYER P, Bromley MJ, Denning DW
    Linking calcium signaling and mitochondrial function in fungal drug resistance.
    Proc Natl Acad Sci U S A. 2020;117:1254-1256.
    PubMed    


  65. LI Y, Zhang Y, Zhang C, Wang H, et al
    Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance.
    Proc Natl Acad Sci U S A. 2020;117:1711-1721.
    PubMed     Abstract available


  66. RUDRA P, Hurst-Hess KR, Cotten KL, Partida-Miranda A, et al
    Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance.
    Proc Natl Acad Sci U S A. 2020;117:629-634.
    PubMed     Abstract available


    November 2019
  67. PATRO SC, Brandt LD, Bale MJ, Halvas EK, et al
    Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.
    Proc Natl Acad Sci U S A. 2019 Nov 27. pii: 1910334116.
    PubMed     Abstract available


  68. TEPEKULE B, Abel Zur Wiesch P, Kouyos RD, Bonhoeffer S, et al
    Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota.
    Proc Natl Acad Sci U S A. 2019;116:23106-23116.
    PubMed     Abstract available


    September 2019
  69. SAFI H, Gopal P, Lingaraju S, Ma S, et al
    Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance.
    Proc Natl Acad Sci U S A. 2019 Sep 5. pii: 1907631116.
    PubMed     Abstract available


    August 2019
  70. FELDMAN MF, Mayer Bridwell AE, Scott NE, Vinogradov E, et al
    A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae.
    Proc Natl Acad Sci U S A. 2019 Aug 27. pii: 1907833116.
    PubMed     Abstract available


    July 2019
  71. TCHESNOKOVA V, Radey M, Chattopadhyay S, Larson L, et al
    Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci.
    Proc Natl Acad Sci U S A. 2019;116:14740-14748.
    PubMed     Abstract available


  72. DI RUSCIO F, Guzzetta G, Bjornholt JV, Leegaard TM, et al
    Quantifying the transmission dynamics of MRSA in the community and healthcare settings in a low-prevalence country.
    Proc Natl Acad Sci U S A. 2019;116:14599-14605.
    PubMed     Abstract available


  73. LEVIN-REISMAN I, Brauner A, Ronin I, Balaban NQ, et al
    Epistasis between antibiotic tolerance, persistence, and resistance mutations.
    Proc Natl Acad Sci U S A. 2019;116:14734-14739.
    PubMed     Abstract available


  74. MISHRA B, Lakshmaiah Narayana J, Lushnikova T, Wang X, et al
    Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens.
    Proc Natl Acad Sci U S A. 2019;116:13517-13522.
    PubMed     Abstract available


    May 2019
  75. FLENTIE K, Harrison GA, Tukenmez H, Livny J, et al
    Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2019 May 6. pii: 1818009116.
    PubMed     Abstract available


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