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Drug Resistance

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 63 articles: HTML format

Single Articles

July 2024
1. BUIJS NP, Vlaming HC, Kotsogianni I, Arts M, et al
   A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens.
   Proc Natl Acad Sci U S A. 2024;121:e2315310121.
   PubMed     Abstract available
   
   
   June 2024
2. BURATA OE, O'Donnell E, Hyun J, Lucero RM, et al
   Peripheral positions encode transport specificity in the small multidrug resistance exporters.
   Proc Natl Acad Sci U S A. 2024;121:e2403273121.
   PubMed     Abstract available
   
   
   
3. OGUNLADE B, Tadesse LF, Li H, Vu N, et al
   Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy.
   Proc Natl Acad Sci U S A. 2024;121:e2315670121.
   PubMed     Abstract available
   
   
   April 2024
4. XU Q, Zhang H, Vandenkoornhuyse P, Guo S, et al
   Carbon starvation raises capacities in bacterial antibiotic resistance and viral auxiliary carbon metabolism in soils.
   Proc Natl Acad Sci U S A. 2024;121:e2318160121.
   PubMed     Abstract available
   
   
   
5. WEAVER DT, King ES, Maltas J, Scott JG, et al
   Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance.
   Proc Natl Acad Sci U S A. 2024;121:e2303165121.
   PubMed     Abstract available
   
   
   
6. BISWAS A, Choudhuri I, Arnold E, Lyumkis D, et al
   Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.
   Proc Natl Acad Sci U S A. 2024;121:e2316662121.
   PubMed     Abstract available
   
   
   March 2024
7. SCHWARTZMAN JA, Lebreton F, Salamzade R, Shea T, et al
   Global diversity of enterococci and description of 18 previously unknown species.
   Proc Natl Acad Sci U S A. 2024;121:e2310852121.
   PubMed     Abstract available
   
   
   December 2023
8. ALONSO-DEL VALLE A, Toribio-Celestino L, Quirant A, Pi CT, et al
   Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.
   Proc Natl Acad Sci U S A. 2023;120:e2314135120.
   PubMed     Abstract available
   
   
   October 2023
9. KOBRAS CM, Monteith W, Somerville S, Delaney JM, et al
   Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae.
   Proc Natl Acad Sci U S A. 2023;120:e2308029120.
   PubMed     Abstract available
   
   
   August 2023
10. MEHROTRA T, Konar D, Pragasam AK, Kumar S, et al
    Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
    Proc Natl Acad Sci U S A. 2023;120:e2305465120.
    PubMed     Abstract available
    
    
    July 2023
11. LI M, Wang P, Zhang K, Zhang H, et al
    Single cobalt atoms anchored on Ti(3)C(2)T(x) with dual reaction sites for efficient adsorption-degradation of antibiotic resistance genes.
    Proc Natl Acad Sci U S A. 2023;120:e2305705120.
    PubMed     Abstract available
    
    
    May 2023
12. VILLALBA MI, Rossetti E, Bonvallat A, Yvanoff C, et al
    Simple optical nanomotion method for single-bacterium viability and antibiotic response testing.
    Proc Natl Acad Sci U S A. 2023;120:e2221284120.
    PubMed     Abstract available
    
    
    April 2023
13. BENZ F, Hall AR
    Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids.
    Proc Natl Acad Sci U S A. 2023;120:e2212147120.
    PubMed     Abstract available
    
    
    February 2023
14. DHINDWAL P, Thompson C, Kos D, Planedin K, et al
    A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.
    Proc Natl Acad Sci U S A. 2023;120:e2219827120.
    PubMed     Abstract available
    
    
    
15. ORNES S
    Researchers turn to tiny robots to fight antibiotic resistance.
    Proc Natl Acad Sci U S A. 2023;120:e2300515120.
    PubMed    
    
    
    January 2023
16. WANG Y, Yu Z, Ding P, Lu J, et al
    Antidepressants can induce mutation and enhance persistence toward multiple antibiotics.
    Proc Natl Acad Sci U S A. 2023;120:e2208344120.
    PubMed     Abstract available
    
    
    
17. PEARL MIZRAHI S, Goyal A, Gore J
    Community interactions drive the evolution of antibiotic tolerance in bacteria.
    Proc Natl Acad Sci U S A. 2023;120:e2209043119.
    PubMed     Abstract available
    
    
    
18. BRANDIS G, Larsson J, Elf J
    Antibiotic perseverance increases the risk of resistance development.
    Proc Natl Acad Sci U S A. 2023;120:e2216216120.
    PubMed     Abstract available
    
    
    October 2022
19. NYE TM, Tukenmez H, Singh P, Flores-Mireles AL, et al
    Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
    Proc Natl Acad Sci U S A. 2022;119:e2210912119.
    PubMed     Abstract available
    
    
    
20. LI L, Chai Y, Peng W, Li D, et al
    Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel.
    Proc Natl Acad Sci U S A. 2022;119:e2210724119.
    PubMed     Abstract available
    
    
    
21. LI HZ, Yang K, Liao H, Lassen SB, et al
    Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics.
    Proc Natl Acad Sci U S A. 2022;119:e2201473119.
    PubMed     Abstract available
    
    
    September 2022
22. DAS SG, Krug J
    Unpredictable repeatability in molecular evolution.
    Proc Natl Acad Sci U S A. 2022;119:e2209373119.
    PubMed     Abstract available
    
    
    
23. HUANG KJ, Pantua H, Diao J, Skippington E, et al
    Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2022;119:e2123117119.
    PubMed     Abstract available
    
    
    
24. WONG JLC, David S, Sanchez-Garrido J, Woo JZ, et al
    Recurrent emergence of Klebsiella pneumoniae carbapenem resistance mediated by an inhibitory ompK36 mRNA secondary structure.
    Proc Natl Acad Sci U S A. 2022;119:e2203593119.
    PubMed     Abstract available
    
    
    
25. ZARNOWSKI R, Sanchez H, Jaromin A, Zarnowska UJ, et al
    A common vesicle proteome drives fungal biofilm development.
    Proc Natl Acad Sci U S A. 2022;119:e2211424119.
    PubMed     Abstract available
    
    
    
26. ROGAWSKI MCQUADE ET, Brennhofer SA, Elwood SE, McMurry TL, et al
    Frequency of bystander exposure to antibiotics for enteropathogenic bacteria among young children in low-resource settings.
    Proc Natl Acad Sci U S A. 2022;119:e2208972119.
    PubMed     Abstract available
    
    
    
27. WILLIS JA, Cheburkanov V, Chen S, Soares JM, et al
    Breaking down antibiotic resistance in methicillin-resistant Staphylococcus aureus: Combining antimicrobial photodynamic and antibiotic treatments.
    Proc Natl Acad Sci U S A. 2022;119:e2208378119.
    PubMed     Abstract available
    
    
    
28. TOBA S, Sato A, Kawai M, Taoda Y, et al
    Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
    Proc Natl Acad Sci U S A. 2022;119:e2206104119.
    PubMed     Abstract available
    
    
    July 2022
29. SINGH AK, De Wijngaert B, Bijnens M, Uyttersprot K, et al
    Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
    Proc Natl Acad Sci U S A. 2022;119:e2203660119.
    PubMed     Abstract available
    
    
    
30. FAIT A, Seif Y, Mikkelsen K, Poudel S, et al
    Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories.
    Proc Natl Acad Sci U S A. 2022;119:e2118262119.
    PubMed     Abstract available
    
    
    
31. RASOULY A, Nudler E
    The very hungry bactericidal antibiotics.
    Proc Natl Acad Sci U S A. 2022;119:e2208035119.
    PubMed    
    
    
    May 2022
32. NEWBURY A, Dawson B, Klumper U, Hesse E, et al
    Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks.
    Proc Natl Acad Sci U S A. 2022;119:e2118361119.
    PubMed     Abstract available
    
    
    
33. LIAKOPOULOS A, Aulin LBS, Buffoni M, Fragkiskou E, et al
    Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.
    Proc Natl Acad Sci U S A. 2022;119:e2121768119.
    PubMed     Abstract available
    
    
    April 2022
34. HERNANDO-AMADO S, Laborda P, Valverde JR, Martinez JL, et al
    Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness.
    Proc Natl Acad Sci U S A. 2022;119:e2109370119.
    PubMed     Abstract available
    
    
    
35. LAUGHLIN ZT, Nandi S, Dey D, Zelinskaya N, et al
    50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
    Proc Natl Acad Sci U S A. 2022;119:e2120352119.
    PubMed     Abstract available
    
    
    
36. GEORGE NL, Schilmiller AL, Orlando BJ
    Conformational snapshots of the bacitracin sensing and resistance transporter BceAB.
    Proc Natl Acad Sci U S A. 2022;119:e2123268119.
    PubMed     Abstract available
    
    
    March 2022
37. ZHANG Q, Wang R, Wang M, Liu C, et al
    Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver.
    Proc Natl Acad Sci U S A. 2022;119:e2119417119.
    PubMed     Abstract available
    
    
    February 2022
38. VASAN AK, Haloi N, Ulrich RJ, Metcalf ME, et al
    Role of internal loop dynamics in antibiotic permeability of outer membrane porins.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available
    
    
    
39. KARITA Y, Limmer DT, Hallatschek O
    Scale-dependent tipping points of bacterial colonization resistance.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available
    
    
    November 2021
40. MARTIN MJ, Corey BW, Sannio F, Hall LR, et al
    Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
41. REITHUBER E, Wixe T, Ludwig KC, Muller A, et al
    THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
42. KONIG G, Sokkar P, Pryk N, Heinrich S, et al
    Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    October 2021
43. DAN L, Li Y, Chen S, Liu J, et al
    A rapidly reversible mutation generates subclonal genetic diversity and unstable drug resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
44. LI J, Sae Her A, Traaseth NJ
    Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    September 2021
45. ADKINS-JABLONSKY SJ, Clark CM, Papoulis SE, Kuhl MD, et al
    Market forces determine the distribution of a leaky function in a simple microbial community.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    August 2021
46. LIM J, Lee JJ, Lee SK, Kim S, et al
    Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
47. CHAHAL J, Gebert LFR, Camargo C, MacRae IJ, et al
    miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
48. OTTONI C, Boric D, Cheronet O, Sparacello V, et al
    Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
49. DIMITRIU T, Matthews AC, Buckling A
    Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    July 2021
50. GRASS LM, Wollenhaupt J, Barthel T, Parfentev I, et al
    Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
51. ZHANG J, Zhao X, Cappiello JR, Yang Y, et al
    Identification of simple arylfluorosulfates as potent agents against resistant bacteria.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    June 2021
52. ARAGAW WW, Lee BM, Yang X, Zimmerman MD, et al
    Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
53. QIAN X, Gunturu S, Sun W, Cole JR, et al
    Long-read sequencing revealed cooccurrence, host range, and potential mobility of antibiotic resistome in cow feces.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    May 2021
54. CHE Y, Yang Y, Xu X, Brinda K, et al
    Reply to Shaw: Challenges for enrichment analysis of AMR gene-bearing plasmids.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    
    
    
    
55. SCHUBERT MG, Goodman DB, Wannier TM, Kaur D, et al
    High-throughput functional variant screens via in vivo production of single-stranded DNA.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    April 2021
56. JO WK, Schadenhofer A, Habierski A, Kaiser FK, et al
    Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    March 2021
57. ANGST DC, Tepekule B, Sun L, Bogos B, et al
    Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
58. LU EY, Chen HH, Zhao H, Ozawa S, et al
    Health and economic impact of the pneumococcal conjugate vaccine in hindering antimicrobial resistance in China.
    Proc Natl Acad Sci U S A. 2021;118:e2004933118.
    PubMed     Abstract available
    
    
    February 2021
59. HUEMER M, Mairpady Shambat S, Bergada-Pijuan J, Soderholm S, et al
    Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
60. CHE Y, Yang Y, Xu X, Brinda K, et al
    Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
61. CARD KJ, Thomas MD, Graves JL Jr, Barrick JE, et al
    Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    January 2021
62. GIRGIS HS, DuPai CD, Lund J, Reeder J, et al
    Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    
    
63. OLDENKAMP R, Schultsz C, Mancini E, Cappuccio A, et al
    Filling the gaps in the global prevalence map of clinical antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available
    
    

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