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Drug Resistance

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 46 articles: HTML format

Single Articles

January 2026
1. MCDONOUGH LD, Li S, Munsamy-Govender V, Gwin CM, et al
   An activator of a two-component system controls cell separation and intrinsic drug resistance in Mycobacterium tuberculosis.
   Proc Natl Acad Sci U S A. 2026;123:e2519608123.
   PubMed     Abstract available
   
   
   
2. HERNANDEZ-BIRD J, He B, VanOtterloo LM, Billings EB, et al
   Resistance, heteroresistance, and fitness costs drive colistin treatment failure during Acinetobacter baumannii pneumonia.
   Proc Natl Acad Sci U S A. 2026;123:e2515303123.
   PubMed     Abstract available
   
   
   December 2025
3. MILLER ST, Henzler-Wildman KA, Raman S
   Energetic and structural control of polyspecificity in a multidrug transporter.
   Proc Natl Acad Sci U S A. 2025;122:e2511892122.
   PubMed     Abstract available
   
   
   
4. TRAN PM, Anaya-Sanchez A, Ji DX, Schwarz MCR, et al
   Cell envelope maintenance by PhoP is essential for Mycobacterium tuberculosis methylglyoxal resistance.
   Proc Natl Acad Sci U S A. 2025;122:e2523024122.
   PubMed     Abstract available
   
   
   
5. ANGELES-SOLANO M, Tabashsum Z, Liu JD, Lifschin ZJ, et al
   Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations.
   Proc Natl Acad Sci U S A. 2025;122:e2524436122.
   PubMed     Abstract available
   
   
   
6. SCHINDL A, Jones ME, Ghimire L, Kalverda AP, et al
   Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G.
   Proc Natl Acad Sci U S A. 2025;122:e2508779122.
   PubMed     Abstract available
   
   
   November 2025
7. HU L, Zhang A, Warshel A
   Exploring evolutionary trajectories of drug resistance.
   Proc Natl Acad Sci U S A. 2025;122:e2517715122.
   PubMed     Abstract available
   
   
   
8. XU JY, Yu YT, Du S, Shen LQ, et al
   Discarded cigarette butts as overlooked reservoirs and amplifiers of antibiotic resistance genes and pathogens in urban green spaces.
   Proc Natl Acad Sci U S A. 2025;122:e2525377122.
   PubMed     Abstract available
   
   
   October 2025
9. SHEN LQ, Lin D, Ye YQ, Liu Y, et al
   Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition.
   Proc Natl Acad Sci U S A. 2025;122:e2516722122.
   PubMed     Abstract available
   
   
   
10. YANG Y, Li Y, Becker ST, Khan A, et al
    Molecular basis of SARS-CoV-2 proofreading enzyme-mediated resistance to remdesivir.
    Proc Natl Acad Sci U S A. 2025;122:e2519755122.
    PubMed     Abstract available
    
    
    September 2025
11. FOUNTAIN AJ, Bohning J, McLaughlin SH, Morgan TE, et al
    Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2516660122.
    PubMed     Abstract available
    
    
    
12. CARD KJ, Crozier D, Durmaz A, Gray J, et al
    Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2025;122:e2507962122.
    PubMed     Abstract available
    
    
    
13. WANG ER, Cho K, Harrison GA, Smelyansky SR, et al
    Metabolic rewiring of isoniazid sensitivity in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2421336122.
    PubMed     Abstract available
    
    
    August 2025
14. XIE T, Lin D, Cai XD, Ma LJ, et al
    Nano-biochar regulates phage-host interactions, reducing antibiotic resistance genes in vermicomposting systems.
    Proc Natl Acad Sci U S A. 2025;122:e2511986122.
    PubMed     Abstract available
    
    
    
15. LAHIRI H, Israeli E, Krugliak M, Basu K, et al
    A bacteria-based search for drugs against avian and swine flu yields a potent and resistance-resilient channel blocker.
    Proc Natl Acad Sci U S A. 2025;122:e2502240122.
    PubMed     Abstract available
    
    
    
16. BOLOURCHI N, Brown CRP, Letten AD, Engelstadter J, et al
    Evolution and evolvability of rifampicin resistance across the bacterial tree of life.
    Proc Natl Acad Sci U S A. 2025;122:e2424307122.
    PubMed     Abstract available
    
    
    July 2025
17. JONES BS, Pareek V, Hu DD, Weaver SD, et al
    N-acetyltransferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in Mycobacterium marinum.
    Proc Natl Acad Sci U S A. 2025;122:e2502577122.
    PubMed     Abstract available
    
    
    June 2025
18. COLQUHOUN JM, Brzezinski CU, Ji A, Marotta J, et al
    Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2025;122:e2423650122.
    PubMed     Abstract available
    
    
    May 2025
19. PEEK J, Bhattacharjee A, Burian J, Hsieh DC, et al
    Environmental resistome-guided development of resistance-tolerant antibiotics.
    Proc Natl Acad Sci U S A. 2025;122:e2504781122.
    PubMed     Abstract available
    
    
    
20. SUN W, Wang J, Wang G, Jiang L, et al
    Exposure and health risks of livestock air resistomes.
    Proc Natl Acad Sci U S A. 2025;122:e2403866122.
    PubMed     Abstract available
    
    
    April 2025
21. PHARKJAKSU S, Cai H, Walter PJ, Chang YC, et al
    Elevated UDP-glucuronic acid levels mend drug resistance and stress responses via a protease and a transporter in Cryptococcus gattii.
    Proc Natl Acad Sci U S A. 2025;122:e2503960122.
    PubMed     Abstract available
    
    
    
22. FOUNTAIN AJ, Waller NJE, Cheung CY, Jowsey W, et al
    Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.
    Proc Natl Acad Sci U S A. 2025;122:e2426827122.
    PubMed     Abstract available
    
    
    
23. WANG Y, Sun L, Fernandes L, Wang YH, et al
    Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688.
    Proc Natl Acad Sci U S A. 2025;122:e2426922122.
    PubMed     Abstract available
    
    
    
24. TSE MW, Zhu M, Peters B, Hamami E, et al
    Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens.
    Proc Natl Acad Sci U S A. 2025;122:e2402017122.
    PubMed     Abstract available
    
    
    February 2025
25. DENK-LOBNIG MK, Wood KB
    Spatial population dynamics of bacterial colonies with social antibiotic resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2417065122.
    PubMed     Abstract available
    
    
    
26. MAJUMDAR S, Kashyap A, Koripella RK, Sharma MR, et al
    HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.
    Proc Natl Acad Sci U S A. 2025;122:e2419826122.
    PubMed     Abstract available
    
    
    
27. ZHANG M, Zhao Y, Cui H, Huang W, et al
    CO(2) potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates.
    Proc Natl Acad Sci U S A. 2025;122:e2417721122.
    PubMed     Abstract available
    
    
    December 2024
28. MUETTER M, Angst DC, Regoes RR, Bonhoeffer S, et al
    The impact of treatment strategies on the epidemiological dynamics of plasmid-conferred antibiotic resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2406818121.
    PubMed     Abstract available
    
    
    
29. DAI L, Wu Z, Sahin O, Zhao S, et al
    Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter.
    Proc Natl Acad Sci U S A. 2024;121:e2415823121.
    PubMed     Abstract available
    
    
    
30. KLEIN EY, Impalli I, Poleon S, Denoel P, et al
    Global trends in antibiotic consumption during 2016-2023 and future projections through 2030.
    Proc Natl Acad Sci U S A. 2024;121:e2411919121.
    PubMed     Abstract available
    
    
    November 2024
31. HUANG J, Larmore CJ, Priest SJ, Xu Z, et al
    Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans.
    Proc Natl Acad Sci U S A. 2024;121:e2416656121.
    PubMed     Abstract available
    
    
    
32. HORAK RD, Ciemniecki JA, Newman DK
    Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance in Pseudomonas aeruginosa.
    Proc Natl Acad Sci U S A. 2024;121:e2406555121.
    PubMed     Abstract available
    
    
    
33. BAUSSIER C, Oriol C, Durand S, Py B, et al
    Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis in Escherichia coli.
    Proc Natl Acad Sci U S A. 2024;121:e2317858121.
    PubMed     Abstract available
    
    
    October 2024
34. RYCROFT JA, Giorgio RT, Sargen M, Helaine S, et al
    Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder.
    Proc Natl Acad Sci U S A. 2024;121:e2405983121.
    PubMed     Abstract available
    
    
    September 2024
35. TUFFET R, Carvalho G, Godeux AS, Mazzamurro F, et al
    Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2024;121:e2409843121.
    PubMed     Abstract available
    
    
    
36. HATTORI SI, Bulut H, Hayashi H, Kishimoto N, et al
    Structural and virologic mechanism of the emergence of resistance to M(pro) inhibitors in SARS-CoV-2.
    Proc Natl Acad Sci U S A. 2024;121:e2404175121.
    PubMed     Abstract available
    
    
    
37. WANG Y, Gao S, Wu F, Gong Y, et al
    Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2403421121.
    PubMed     Abstract available
    
    
    July 2024
38. BUIJS NP, Vlaming HC, Kotsogianni I, Arts M, et al
    A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens.
    Proc Natl Acad Sci U S A. 2024;121:e2315310121.
    PubMed     Abstract available
    
    
    June 2024
39. BURATA OE, O'Donnell E, Hyun J, Lucero RM, et al
    Peripheral positions encode transport specificity in the small multidrug resistance exporters.
    Proc Natl Acad Sci U S A. 2024;121:e2403273121.
    PubMed     Abstract available
    
    
    
40. OGUNLADE B, Tadesse LF, Li H, Vu N, et al
    Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy.
    Proc Natl Acad Sci U S A. 2024;121:e2315670121.
    PubMed     Abstract available
    
    
    April 2024
41. XU Q, Zhang H, Vandenkoornhuyse P, Guo S, et al
    Carbon starvation raises capacities in bacterial antibiotic resistance and viral auxiliary carbon metabolism in soils.
    Proc Natl Acad Sci U S A. 2024;121:e2318160121.
    PubMed     Abstract available
    
    
    
42. WEAVER DT, King ES, Maltas J, Scott JG, et al
    Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2303165121.
    PubMed     Abstract available
    
    
    
43. BISWAS A, Choudhuri I, Arnold E, Lyumkis D, et al
    Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.
    Proc Natl Acad Sci U S A. 2024;121:e2316662121.
    PubMed     Abstract available
    
    
    March 2024
44. SCHWARTZMAN JA, Lebreton F, Salamzade R, Shea T, et al
    Global diversity of enterococci and description of 18 previously unknown species.
    Proc Natl Acad Sci U S A. 2024;121:e2310852121.
    PubMed     Abstract available
    
    
    December 2023
45. ALONSO-DEL VALLE A, Toribio-Celestino L, Quirant A, Pi CT, et al
    Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.
    Proc Natl Acad Sci U S A. 2023;120:e2314135120.
    PubMed     Abstract available
    
    
    October 2023
46. KOBRAS CM, Monteith W, Somerville S, Delaney JM, et al
    Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae.
    Proc Natl Acad Sci U S A. 2023;120:e2308029120.
    PubMed     Abstract available
    
    

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