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  Drug Resistance

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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 54 articles:
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    July 2019
  1. KIM W, Zou G, Hari TPA, Wilt IK, et al
    A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2019 Jul 29. pii: 1904700116.
    PubMed     Text format     Abstract available


    March 2019
  2. CAREY J
    News Feature: Interested in gauging a population's health? Look to sewage.
    Proc Natl Acad Sci U S A. 2019;116:5836-5839.
    PubMed     Text format    


  3. VERMA J, Bag S, Saha B, Kumar P, et al
    Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae.
    Proc Natl Acad Sci U S A. 2019;116:6226-6231.
    PubMed     Text format     Abstract available


  4. DROHAN SE, Levin SA, Grenfell BT, Laxminarayan R, et al
    Incentivizing hospital infection control.
    Proc Natl Acad Sci U S A. 2019;116:6221-6225.
    PubMed     Text format     Abstract available


  5. STOCKS CJ, Phan MD, Achard MES, Nhu NTK, et al
    Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination.
    Proc Natl Acad Sci U S A. 2019;116:6341-6350.
    PubMed     Text format     Abstract available


    February 2019
  6. JIANG JH, Bhuiyan MS, Shen HH, Cameron DR, et al
    Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation.
    Proc Natl Acad Sci U S A. 2019;116:3722-3727.
    PubMed     Text format     Abstract available



  7. Correction for Copin et al., Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2019 Feb 25. pii: 1902207116.
    PubMed     Text format    


    January 2019
  8. DI VENANZIO G, Moon KH, Weber BS, Lopez J, et al
    Multidrug-resistant plasmids repress chromosomally encoded T6SS to enable their dissemination.
    Proc Natl Acad Sci U S A. 2019;116:1378-1383.
    PubMed     Text format     Abstract available


  9. DE METS F, Van Melderen L, Gottesman S
    Regulation of acetate metabolism and coordination with the TCA cycle via a processed small RNA.
    Proc Natl Acad Sci U S A. 2019;116:1043-1052.
    PubMed     Text format     Abstract available


  10. COPIN R, Sause WE, Fulmer Y, Balasubramanian D, et al
    Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2019 Jan 11. pii: 1814265116.
    PubMed     Text format     Abstract available


  11. PETHE MA, Rubenstein AB, Khare SD
    Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations.
    Proc Natl Acad Sci U S A. 2019;116:168-176.
    PubMed     Text format     Abstract available


    December 2018
  12. DUVAL M, Dar D, Carvalho F, Rocha EPC, et al
    HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance.
    Proc Natl Acad Sci U S A. 2018;115:13359-13364.
    PubMed     Text format     Abstract available


  13. TEDIJANTO C, Olesen SW, Grad YH, Lipsitch M, et al
    Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora.
    Proc Natl Acad Sci U S A. 2018;115:E11988-E11995.
    PubMed     Text format     Abstract available


  14. BLOOM DE, Black S, Salisbury D, Rappuoli R, et al
    Antimicrobial resistance and the role of vaccines.
    Proc Natl Acad Sci U S A. 2018;115:12868-12871.
    PubMed     Text format    


  15. SEVILLA JP, Bloom DE, Cadarette D, Jit M, et al
    Toward economic evaluation of the value of vaccines and other health technologies in addressing AMR.
    Proc Natl Acad Sci U S A. 2018;115:12911-12919.
    PubMed     Text format     Abstract available


  16. KLEMM EJ, Wong VK, Dougan G
    Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.
    Proc Natl Acad Sci U S A. 2018;115:12872-12877.
    PubMed     Text format     Abstract available


  17. KENNEDY DA, Read AF
    Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.
    Proc Natl Acad Sci U S A. 2018;115:12878-12886.
    PubMed     Text format     Abstract available


  18. KLUGMAN KP, Black S
    Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects.
    Proc Natl Acad Sci U S A. 2018;115:12896-12901.
    PubMed     Text format     Abstract available


  19. BAKER SJ, Payne DJ, Rappuoli R, De Gregorio E, et al
    Technologies to address antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2018;115:12887-12895.
    PubMed     Text format     Abstract available


  20. RELMAN DA, Lipsitch M
    Microbiome as a tool and a target in the effort to address antimicrobial resistance.
    Proc Natl Acad Sci U S A. 2018;115:12902-12910.
    PubMed     Text format     Abstract available


  21. PURDY MD, Shi D, Chrustowicz J, Hattne J, et al
    MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.
    Proc Natl Acad Sci U S A. 2018 Dec 10. pii: 1806806115.
    PubMed     Text format     Abstract available


    November 2018
  22. DEMERS EG, Biermann AR, Masonjones S, Crocker AW, et al
    Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection.
    Proc Natl Acad Sci U S A. 2018 Nov 2. pii: 1807698115.
    PubMed     Text format     Abstract available


    October 2018
  23. GOLDHILL DH, Te Velthuis AJW, Fletcher RA, Langat P, et al
    The mechanism of resistance to favipiravir in influenza.
    Proc Natl Acad Sci U S A. 2018 Oct 23. pii: 1811345115.
    PubMed     Text format     Abstract available


  24. PETERS K, Pazos M, Edoo Z, Hugonnet JE, et al
    Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins.
    Proc Natl Acad Sci U S A. 2018;115:10786-10791.
    PubMed     Text format     Abstract available


    September 2018
  25. ROEMHILD R, Gokhale CS, Dirksen P, Blake C, et al
    Cellular hysteresis as a principle to maximize the efficacy of antibiotic therapy.
    Proc Natl Acad Sci U S A. 2018;115:9767-9772.
    PubMed     Text format     Abstract available


  26. MARTINS D, McKay G, Sampathkumar G, Khakimova M, et al
    Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.
    Proc Natl Acad Sci U S A. 2018;115:9797-9802.
    PubMed     Text format     Abstract available


  27. BEAUPERE C, Dinatto L, Wasko BM, Chen RB, et al
    Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.
    Proc Natl Acad Sci U S A. 2018;115:9586-9591.
    PubMed     Text format     Abstract available


  28. TEREKHOV SS, Smirnov IV, Malakhova MV, Samoilov AE, et al
    Ultrahigh-throughput functional profiling of microbiota communities.
    Proc Natl Acad Sci U S A. 2018;115:9551-9556.
    PubMed     Text format     Abstract available


  29. CROWE-MCAULIFFE C, Graf M, Huter P, Takada H, et al
    Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.
    Proc Natl Acad Sci U S A. 2018;115:8978-8983.
    PubMed     Text format     Abstract available


    August 2018
  30. TIWARI S, van Tonder AJ, Vilcheze C, Mendes V, et al
    Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2018 Aug 24. pii: 1808874115.
    PubMed     Text format     Abstract available


  31. OVCHINNIKOV V, Stone TA, Deber CM, Karplus M, et al
    Structure of the EmrE multidrug transporter and its use for inhibitor peptide design.
    Proc Natl Acad Sci U S A. 2018;115:E7932-E7941.
    PubMed     Text format     Abstract available


  32. LI Y, Sharma MR, Koripella RK, Yang Y, et al
    Zinc depletion induces ribosome hibernation in mycobacteria.
    Proc Natl Acad Sci U S A. 2018;115:8191-8196.
    PubMed     Text format     Abstract available


  33. PARACINI N, Clifton LA, Skoda MWA, Lakey JH, et al
    Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility.
    Proc Natl Acad Sci U S A. 2018;115:E7587-E7594.
    PubMed     Text format     Abstract available


  34. VERMAAS JV, Rempe SB, Tajkhorshid E
    Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE.
    Proc Natl Acad Sci U S A. 2018;115:E7502-E7511.
    PubMed     Text format     Abstract available


    July 2018
  35. KIRKMAN LA, Zhan W, Visone J, Dziedziech A, et al
    Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
    Proc Natl Acad Sci U S A. 2018;115:E6863-E6870.
    PubMed     Text format     Abstract available


  36. KE R, Li H, Wang S, Ding W, et al
    Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence.
    Proc Natl Acad Sci U S A. 2018 Jul 9. pii: 1805267115.
    PubMed     Text format     Abstract available


  37. HARRIS KA, Zhou Z, Peters ML, Wilkins SG, et al
    A second RNA-binding protein is essential for ethanol tolerance provided by the bacterial OLE ribonucleoprotein complex.
    Proc Natl Acad Sci U S A. 2018;115:E6319-E6328.
    PubMed     Text format     Abstract available


    June 2018
  38. NYERGES A, Csorgo B, Draskovits G, Kintses B, et al
    Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
    Proc Natl Acad Sci U S A. 2018;115:E5726-E5735.
    PubMed     Text format     Abstract available


    May 2018
  39. CORNFORTH DM, Dees JL, Ibberson CB, Huse HK, et al
    Pseudomonas aeruginosa transcriptome during human infection.
    Proc Natl Acad Sci U S A. 2018;115:E5125-E5134.
    PubMed     Text format     Abstract available


  40. BEHRINGER MG, Choi BI, Miller SF, Doak TG, et al
    Escherichia coli cultures maintain stable subpopulation structure during long-term evolution.
    Proc Natl Acad Sci U S A. 2018;115:E4642-E4650.
    PubMed     Text format     Abstract available


  41. SU W, Kumar V, Ding Y, Ero R, et al
    Ribosome protection by antibiotic resistance ATP-binding cassette protein.
    Proc Natl Acad Sci U S A. 2018;115:5157-5162.
    PubMed     Text format     Abstract available


    April 2018
  42. KLEIN EY, Van Boeckel TP, Martinez EM, Pant S, et al
    Global increase and geographic convergence in antibiotic consumption between 2000 and 2015.
    Proc Natl Acad Sci U S A. 2018;115:E3463-E3470.
    PubMed     Text format     Abstract available


  43. CHAVEZ A, Pruitt BW, Tuttle M, Shapiro RS, et al
    Precise Cas9 targeting enables genomic mutation prevention.
    Proc Natl Acad Sci U S A. 2018;115:3669-3673.
    PubMed     Text format     Abstract available


    March 2018
  44. OBOLSKI U, Lourenco J, Thompson C, Thompson R, et al
    Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae.
    Proc Natl Acad Sci U S A. 2018 Mar 6. pii: 1718712115.
    PubMed     Text format     Abstract available


    January 2018
  45. SLUIS-CREMER N
    Future of nonnucleoside reverse transcriptase inhibitors.
    Proc Natl Acad Sci U S A. 2018;115:637-638.
    PubMed     Text format    


    October 2017
  46. DESHMUKH L, Tugarinov V, Louis JM, Clore GM, et al
    Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR.
    Proc Natl Acad Sci U S A. 2017 Oct 30. pii: 201716098.
    PubMed     Text format     Abstract available


    August 2017
  47. CHAN AH, Lee WG, Spasov KA, Cisneros JA, et al
    Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
    Proc Natl Acad Sci U S A. 2017 Aug 21. pii: 201711463.
    PubMed     Text format     Abstract available


    July 2017
  48. DEFRANCESCO AS, Masloboeva N, Syed AK, DeLoughery A, et al
    Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2017 Jul 3. pii: 201704544.
    PubMed     Text format     Abstract available


    May 2017
  49. SAITO K, Warrier T, Somersan-Karakaya S, Kaminski L, et al
    Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.
    Proc Natl Acad Sci U S A. 2017 May 30. pii: 201705385.
    PubMed     Text format     Abstract available


    April 2017
  50. VILCHEZE C, Hartman T, Weinrick B, Jain P, et al
    Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Apr 10. pii: 201704376.
    PubMed     Text format     Abstract available


    February 2017
  51. KOIZUMI Y, Ohashi H, Nakajima S, Tanaka Y, et al
    Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection.
    Proc Natl Acad Sci U S A. 2017 Feb 7. pii: 201610197.
    PubMed     Text format     Abstract available


    November 2016
  52. ELDHOLM V, Pettersson JH, Brynildsrud OB, Kitchen A, et al
    Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Nov 21. pii: 201611283.
    PubMed     Text format     Abstract available


    October 2016
  53. DESHMUKH L, Louis JM, Ghirlando R, Clore GM, et al
    Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations.
    Proc Natl Acad Sci U S A. 2016 Oct 17. pii: 201615342.
    PubMed     Text format     Abstract available


    July 2016
  54. WARRIER T, Kapilashrami K, Argyrou A, Ioerger TR, et al
    N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Jul 18. pii: 201606590.
    PubMed     Text format     Abstract available


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