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Ophthalmology

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 70 articles: HTML format

Single Articles

November 2026
1. ZHANG J, Du M, Ge L, Cao Y, et al
   A tetravalent bispecific protein enables targeted degradation of VCAM-1 and VEGFR for treatment of choroidal neovascularization.
   Proc Natl Acad Sci U S A. 2026;123:e2613631123.
   PubMed     Abstract available
   
   
   
2. LI G, Chai Z, Zhang S, Ren Y, et al
   Ectopic expression of melanopsin promotes axonal regeneration in retinal ganglion cells via cAMP and TRPC signaling.
   Proc Natl Acad Sci U S A. 2026;123:e2628062123.
   PubMed     Abstract available
   
   
   October 2026
3. SHARMA S, Alahdab G, Haque MN, Karkoukli I, et al
   Bone morphogenetic protein signaling as a key regulator of retinal fibrosis.
   Proc Natl Acad Sci U S A. 2026;123:e2603111123.
   PubMed     Abstract available
   
   
   
4. SERMET BS, Kamermans W, Winkelman BHJ, De Zeeuw CI, et al
   Dopamine suppresses pathological retinal oscillations and enhances the signal-to-noise ratio.
   Proc Natl Acad Sci U S A. 2026;123:e2535572123.
   PubMed     Abstract available
   
   
   September 2026
5. SESSA P, Schiano Lomoriello A, Quettier T, Maffei A, et al
   Facial palsy reveals the sensorimotor contribution to facial-emotion recognition.
   Proc Natl Acad Sci U S A. 2026;123:e2608511123.
   PubMed     Abstract available
   
   
   
6. JIANG YX, Salwinski L, Sawaya MR, Ge P, et al
   Cryo-EM structure of TGFBIp fibrils driven by a corneal dystrophy-linked mutation enables design of peptide inhibitors of aggregation.
   Proc Natl Acad Sci U S A. 2026;123:e2607937123.
   PubMed     Abstract available
   
   
   
7. CHENG FF, Mou H, Liu Z, Zhang CJ, et al
   Genetic evidence and cross-species functional characterization implicate CNN2 in age-related macular degeneration susceptibility.
   Proc Natl Acad Sci U S A. 2026;123:e2533682123.
   PubMed     Abstract available
   
   
   
8. ARCO-HIERVES A, Pamboukas K, Bilonda Mutala L, Borowski LS, et al
   Loss of epitranscriptomic mitochondrial RNA surveillance drives epithelial type I interferon and inflammation in autoimmunity.
   Proc Natl Acad Sci U S A. 2026;123:e2534325123.
   PubMed     Abstract available
   
   
   August 2026
9. ZHANG YC, Ding ZQ, Xu SY, Chen JY, et al
   ALKBH3 inhibition normalizes neovessels by reprogramming endothelial fate in diabetic microvasculopathy.
   Proc Natl Acad Sci U S A. 2026;123:e2602779123.
   PubMed     Abstract available
   
   
   
10. COLASANTI JJ, Santeford A, Lin JB, Terao R, et al
    MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration.
    Proc Natl Acad Sci U S A. 2026;123:e2524037123.
    PubMed     Abstract available
    
    
    
11. WANG S, Zhao S, Daniels A, Naaman E, et al
    AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD.
    Proc Natl Acad Sci U S A. 2026;123:e2616985123.
    PubMed     Abstract available
    
    
    
12. SAADANE A, von Lintig J
    Maternal nutrition determines the variable expressivity of STRA6-associated eye malformations.
    Proc Natl Acad Sci U S A. 2026;123:e2608068123.
    PubMed     Abstract available
    
    
    July 2026
13. SHETTIGAR M, Mouliere S, Isenegger L, DeVine AL, et al
    Oncogenic Galpha signaling requires AP-3-dependent recruitment to the endolysosomal compartment.
    Proc Natl Acad Sci U S A. 2026;123:e2615774123.
    PubMed     Abstract available
    
    
    
14. NASR S, Skerswetat J, Kennedy B, Schmidt ME, et al
    Mesoscale developmental rivalry in the human extrastriate visual cortex.
    Proc Natl Acad Sci U S A. 2026;123:e2600746123.
    PubMed     Abstract available
    
    
    
15. GAO Y, Li X, Dai L, Luo X, et al
    Costunolide ameliorates autoimmune uveitis by targeting USP15 to suppress TNF-alpha-induced retinal endothelial inflammation.
    Proc Natl Acad Sci U S A. 2026;123:e2533845123.
    PubMed     Abstract available
    
    
    June 2026
16. OZAKI E, Aktas S, Mulfaul K, Brennan K, et al
    Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.
    Proc Natl Acad Sci U S A. 2026;123:e2519056123.
    PubMed     Abstract available
    
    
    
17. GUAN Z, Li W, Liu S, Yang X, et al
    Drp1-driven fragmentation of scleral mitochondria promotes myopia development.
    Proc Natl Acad Sci U S A. 2026;123:e2511427123.
    PubMed     Abstract available
    
    
    
18. LY K, Bhuckory MB, Pham-Howard D, Kochnev Goldstein A, et al
    Residual photoreceptors affect the response of a degenerate retina to electrical stimulation.
    Proc Natl Acad Sci U S A. 2026;123:e2537064123.
    PubMed     Abstract available
    
    
    May 2026
19. GOMEZ-SINTES R, Tasset I, Ramirez-Pardo I, Martin-Segura A, et al
    Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes.
    Proc Natl Acad Sci U S A. 2026;123:e2527503123.
    PubMed     Abstract available
    
    
    
20. BERNSTEIN SL, Mehrabian Z, Guo Y, Jouffroy J, et al
    Hopx(+) optic nerve head-astrocytes counter neuronal stress and glaucoma damage.
    Proc Natl Acad Sci U S A. 2026;123:e2515277123.
    PubMed     Abstract available
    
    
    April 2026
21. JAGGERS TN, Ripolles-Garcia A, Moshiri A, Story BD, et al
    Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy.
    Proc Natl Acad Sci U S A. 2026;123:e2509165123.
    PubMed     Abstract available
    
    
    
22. BRILLANTE S, Volpe M, Diana A, Negueruela S, et al
    Uncovering mitochondrial defects in photoreceptors opens therapeutic opportunities for Stargardt disease.
    Proc Natl Acad Sci U S A. 2026;123:e2504764123.
    PubMed     Abstract available
    
    
    February 2026
23. LI Y, Jing M, Wang W, Lin W, et al
    DAPL1 restrains RPE PANoptosis in experimental AMD by inhibiting GRP75-mediated mitochondria-associated endoplasmic reticulum membranes.
    Proc Natl Acad Sci U S A. 2026;123:e2511926123.
    PubMed     Abstract available
    
    
    
24. CUI T, Wen Q, An Z, Kang J, et al
    Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1-astrocytic integrin alpha4 interaction.
    Proc Natl Acad Sci U S A. 2026;123:e2520566123.
    PubMed     Abstract available
    
    
    
25. WANG X, Jing X, Guo Z, Long S, et al
    Coviretinopathy: COVID-19-induced VEGF-dependent retinopathy.
    Proc Natl Acad Sci U S A. 2026;123:e2516405123.
    PubMed     Abstract available
    
    
    January 2026
26. SINGH KK, Jin Y, Hu MW, Palazzo I, et al
    Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium.
    Proc Natl Acad Sci U S A. 2026;123:e2505412123.
    PubMed     Abstract available
    
    
    December 2025
27. RIAHI Z, Boucher S, Abdi S, Wong Jun Tai F, et al
    Genetics of prelingual isolated deafness and Usher syndrome in the Maghreb and Jordan: Harnessing the potential of homozygosity.
    Proc Natl Acad Sci U S A. 2025;122:e2518445122.
    PubMed     Abstract available
    
    
    November 2025
28. WANG S, Li M, Chen G, Chen Z, et al
    Joubert syndrome 26 protein enforces compartmentalized motility of a ciliary kinesin.
    Proc Natl Acad Sci U S A. 2025;122:e2504374122.
    PubMed     Abstract available
    
    
    
29. SHEN W, Nie Z, Wang M, Zhang H, et al
    Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization.
    Proc Natl Acad Sci U S A. 2025;122:e2501704122.
    PubMed     Abstract available
    
    
    October 2025
30. SOTANI N, Kusuhara S, Nishisho R, Kuno H, et al
    Transpupillary in vivo two-photon imaging reveals enhanced surveillance of retinal microglia in diabetic mice.
    Proc Natl Acad Sci U S A. 2025;122:e2426241122.
    PubMed     Abstract available
    
    
    September 2025
31. MA E, Schafer CM, Xie J, Rudenko Y, et al
    Targeting endothelial ERG to mitigate vascular regression in retinopathies.
    Proc Natl Acad Sci U S A. 2025;122:e2507194122.
    PubMed     Abstract available
    
    
    
32. STANHOPE SC, Singhal K, Morato NM, Feng Y, et al
    Drosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2511388122.
    PubMed     Abstract available
    
    
    
33. WANG J, Zhou C, Zhuang K, Zou J, et al
    Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission.
    Proc Natl Acad Sci U S A. 2025;122:e2426578122.
    PubMed     Abstract available
    
    
    
34. GOMES C, Huang KC, Lavekar SS, Harkin J, et al
    Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms.
    Proc Natl Acad Sci U S A. 2025;122:e2423682122.
    PubMed     Abstract available
    
    
    
35. LIAO M, Ye Z, Zhao Y, Nan J, et al
    Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy.
    Proc Natl Acad Sci U S A. 2025;122:e2424487122.
    PubMed     Abstract available
    
    
    August 2025
36. HUANG Y, Lin H, Shi J, Chen Y, et al
    Serum metabolic patterns reveal the diagnostic and prognostic role of alanine abnormality in ocular adnexal lymphoma.
    Proc Natl Acad Sci U S A. 2025;122:e2506345122.
    PubMed     Abstract available
    
    
    July 2025
37. WANG Z, Anderson DMG, Messinger JD, Curcio CA, et al
    Glycolipids implicated as mediators of clinically visible retinal pigment epithelial migration in age-related macular degeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2503191122.
    PubMed     Abstract available
    
    
    June 2025
38. TOOMEY CB, Pflugmacher S, Park K, Pihl J, et al
    Bruch's membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2500727122.
    PubMed     Abstract available
    
    
    
39. WANG Y, Zhang YC, Ding ZQ, Xu SY, et al
    Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology.
    Proc Natl Acad Sci U S A. 2025;122:e2416046122.
    PubMed     Abstract available
    
    
    May 2025
40. MURPHY DP, Kolesnikov AV, Montana CL, Khaja ZM, et al
    Mechanisms of photoreceptor protection upon targeting the Nrl-Nr2e3 pathway.
    Proc Natl Acad Sci U S A. 2025;122:e2500446122.
    PubMed     Abstract available
    
    
    
41. JUN DJ, Schumacher MM, Jo Y, Faulkner RA, et al
    Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening.
    Proc Natl Acad Sci U S A. 2025;122:e2426532122.
    PubMed     Abstract available
    
    
    
42. ZHANG J, Yang W, Wu J, Lin B, et al
    Understanding TAK1 deficiency in microglia: Dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa.
    Proc Natl Acad Sci U S A. 2025;122:e2423134122.
    PubMed     Abstract available
    
    
    
43. MARTIN M, Bolognesi B
    Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension.
    Proc Natl Acad Sci U S A. 2025;122:e2415521122.
    PubMed     Abstract available
    
    
    April 2025
44. TWORAK A, Smidak R, Rodrigues Menezes C, Du SW, et al
    MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids.
    Proc Natl Acad Sci U S A. 2025;122:e2425523122.
    PubMed     Abstract available
    
    
    
45. CHANDLER LC, Gardner A, Cepko CL
    RPE-specific MCT2 expression promotes cone survival in models of retinitis pigmentosa.
    Proc Natl Acad Sci U S A. 2025;122:e2421978122.
    PubMed     Abstract available
    
    
    March 2025
46. COOPER ML, Gildea HK, Selles MC, Katafygiotou E, et al
    Astrocytes in the mouse brain respond bilaterally to unilateral retinal neurodegeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2418249122.
    PubMed     Abstract available
    
    
    
47. DVORIANTCHIKOVA G, Moulin C, Fleishaker M, Almeida V, et al
    Genetic ablation of the TET family in retinal progenitor cells impairs photoreceptor development and leads to blindness.
    Proc Natl Acad Sci U S A. 2025;122:e2420091122.
    PubMed     Abstract available
    
    
    February 2025
48. VOLZ S, Malone JR, Guseman AJ, Gronenborn AM, et al
    Cataract-prone variants of gammaD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions.
    Proc Natl Acad Sci U S A. 2025;122:e2410860122.
    PubMed     Abstract available
    
    
    January 2025
49. BISWAS N, Mori T, Ragava Chetty Nagaraj NK, Xin H, et al
    Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2418752122.
    PubMed     Abstract available
    
    
    
50. BUTENKO K, Neudorfer C, Dembek TA, Hollunder B, et al
    Engaging dystonia networks with subthalamic stimulation.
    Proc Natl Acad Sci U S A. 2025;122:e2417617122.
    PubMed     Abstract available
    
    
    December 2024
51. HATA M, Hata M, Dejda A, Pilon F, et al
    Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.
    Proc Natl Acad Sci U S A. 2024;121:e2411640121.
    PubMed     Abstract available
    
    
    
52. HILDEBRANDT M, Kotewitsch M, Kaupp S, Salomon S, et al
    Stabilizing selection in an identified multisensory neuron in blind cavefish.
    Proc Natl Acad Sci U S A. 2024;121:e2415854121.
    PubMed     Abstract available
    
    
    
53. PATEL A, Pauzuolyte V, Ingham NJ, Leong YC, et al
    Rescue of cochlear vascular pathology prevents sensory hair cell loss in Norrie disease.
    Proc Natl Acad Sci U S A. 2024;121:e2322124121.
    PubMed     Abstract available
    
    
    November 2024
54. WEI Z, Hao C, Radeen KR, Hao Z, et al
    Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract.
    Proc Natl Acad Sci U S A. 2024;121:e2407842121.
    PubMed     Abstract available
    
    
    
55. VEREERTBRUGGHEN A, Pizzano M, Cernutto A, Sabbione F, et al
    CD4(+) T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model.
    Proc Natl Acad Sci U S A. 2024;121:e2407648121.
    PubMed     Abstract available
    
    
    
56. DU SW, Newby GA, Salom D, Gao F, et al
    In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2416827121.
    PubMed     Abstract available
    
    
    
57. SHARMA D, Lau E, Qin Y, Jee K, et al
    VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.
    Proc Natl Acad Sci U S A. 2024;121:e2322759121.
    PubMed     Abstract available
    
    
    October 2024
58. CHANG D, Caterina MJ
    Pinning down a perpetrator in postsurgical eye pain.
    Proc Natl Acad Sci U S A. 2024;121:e2417221121.
    PubMed    
    
    
    
59. PATHAK V, Bertelli PM, Pedrini E, Harkin K, et al
    Modulation of diabetes-related retinal pathophysiology by PTX3.
    Proc Natl Acad Sci U S A. 2024;121:e2320034121.
    PubMed     Abstract available
    
    
    September 2024
60. LI W, He S, Tan J, Li N, et al
    Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
    Proc Natl Acad Sci U S A. 2024;121:e2316161121.
    PubMed     Abstract available
    
    
    
61. LIU Y, Wang A, Chen C, Zhang Q, et al
    Microglial cGAS-STING signaling underlies glaucoma pathogenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2409493121.
    PubMed     Abstract available
    
    
    August 2024
62. AMARAL L, Thomas P, Amedi A, Striem-Amit E, et al
    Longitudinal stability of individual brain plasticity patterns in blindness.
    Proc Natl Acad Sci U S A. 2024;121:e2320251121.
    PubMed     Abstract available
    
    
    July 2024
63. BORKAR S, Baumli P, Vance T, Sharma E, et al
    Elucidating the roles of electrolytes and hydrogen bonding in the dewetting dynamics of the tear film.
    Proc Natl Acad Sci U S A. 2024;121:e2407501121.
    PubMed     Abstract available
    
    
    June 2024
64. CHEN M, Wang Y, Dalal R, Du J, et al
    Alternative oxidase blunts pseudohypoxia and photoreceptor degeneration due to RPE mitochondrial dysfunction.
    Proc Natl Acad Sci U S A. 2024;121:e2402384121.
    PubMed     Abstract available
    
    
    May 2024
65. GOTO S, Tsutsumi A, Lee Y, Hosojima M, et al
    Cryo-EM structures elucidate the multiligand receptor nature of megalin.
    Proc Natl Acad Sci U S A. 2024;121:e2318859121.
    PubMed     Abstract available
    
    
    
66. FAIN GL
    The mechanism of genetically inherited night blindness.
    Proc Natl Acad Sci U S A. 2024;121:e2408254121.
    PubMed    
    
    
    
67. CHAI Z, Ye Y, Silverman D, Rose K, et al
    Dark continuous noise from mutant G90D-rhodopsin predominantly underlies congenital stationary night blindness.
    Proc Natl Acad Sci U S A. 2024;121:e2404763121.
    PubMed     Abstract available
    
    
    April 2024
68. LIU Y, Liu X, Chen X, Yang Z, et al
    Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina.
    Proc Natl Acad Sci U S A. 2024;121:e2311028121.
    PubMed     Abstract available
    
    
    March 2024
69. KOLESNIKOV AV, Murphy DP, Corbo JC, Kefalov VJ, et al
    Germline knockout of Nr2e3 protects photoreceptors in three distinct mouse models of retinal degeneration.
    Proc Natl Acad Sci U S A. 2024;121:e2316118121.
    PubMed     Abstract available
    
    
    
70. KOJIMA Y, Ito RK, Fukuyama I, Ohkubo Y, et al
    Foraging predicts the evolution of warning coloration and mimicry in snakes.
    Proc Natl Acad Sci U S A. 2024;121:e2318857121.
    PubMed     Abstract available
    
    

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