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  Liver Diseases

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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 22 articles:
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Single Articles


    September 2025
  1. YUAN Y, Niu Y, Huang Z, Shi Y, et al
    USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2025;122:e2510576122.
    PubMed     Abstract available


    August 2025
  2. CHEN P, Geng H, Ma B, Zhang Y, et al
    Integrating spatial omics and single-cell mass spectrometry imaging reveals tumor-host metabolic interplay in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2025;122:e2505789122.
    PubMed     Abstract available


    July 2025
  3. WU J, Gao M, Wu X, Liu Y, et al
    PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis.
    Proc Natl Acad Sci U S A. 2025;122:e2504219122.
    PubMed     Abstract available


    June 2025
  4. OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al
    Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420174122.
    PubMed     Abstract available


    May 2025
  5. ZHANG Y, Zuo A, Ba Y, Liu S, et al
    Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.
    Proc Natl Acad Sci U S A. 2025;122:e2423077122.
    PubMed     Abstract available


  6. SAKUMA I, Gaspar RC, Nasiri AR, Dufour S, et al
    Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
    Proc Natl Acad Sci U S A. 2025;122:e2502978122.
    PubMed     Abstract available


    February 2025
  7. QIAN X, Zhou Q, Ouyang Y, Wu X, et al
    Transferrin promotes fatty acid oxidation and liver tumor growth through PHD2-mediated PPARalpha hydroxylation in an iron-dependent manner.
    Proc Natl Acad Sci U S A. 2025;122:e2412473122.
    PubMed     Abstract available


    January 2025
  8. SUN L, Hu P, Yang H, Ren J, et al
    ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA.
    Proc Natl Acad Sci U S A. 2025;122:e2409724122.
    PubMed     Abstract available


  9. XU X, Penjweini R, Szekvolgyi L, Karanyi Z, et al
    Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA(Thr) production.
    Proc Natl Acad Sci U S A. 2025;122:e2411298122.
    PubMed     Abstract available


  10. WANG J, Liao L, Miao B, Yang B, et al
    Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.
    Proc Natl Acad Sci U S A. 2025;122:e2419625121.
    PubMed     Abstract available


  11. SHI W, Yi X, Ruan H, Wang D, et al
    An animal model recapitulates human hepatic diseases associated with GATA6 mutations.
    Proc Natl Acad Sci U S A. 2025;122:e2317801121.
    PubMed     Abstract available


    October 2024
  12. JIANG L, Qi X, Lai M, Zhou J, et al
    WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc.
    Proc Natl Acad Sci U S A. 2024;121:e2407904121.
    PubMed     Abstract available


  13. BAI J, Jiang P, Ji L, Lam WKJ, et al
    Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns.
    Proc Natl Acad Sci U S A. 2024;121:e2404058121.
    PubMed     Abstract available


    August 2024
  14. GANGULY S, Rosenthal SB, Ishizuka K, Troutman TD, et al
    Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2.
    Proc Natl Acad Sci U S A. 2024;121:e2405746121.
    PubMed     Abstract available


    April 2024
  15. SHERMAN DJ, Liu L, Mamrosh JL, Xie J, et al
    The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics.
    Proc Natl Acad Sci U S A. 2024;121:e2318619121.
    PubMed     Abstract available


  16. BAKIRI L, Hasenfuss SC, Guio-Carrion A, Thomsen MK, et al
    Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.
    Proc Natl Acad Sci U S A. 2024;121:e2404188121.
    PubMed     Abstract available


  17. GU L, Du Y, Chen J, Hasan MN, et al
    Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2320934121.
    PubMed     Abstract available


    February 2024
  18. DAS A, Cheng H, Wang Y, Kinch LN, et al
    The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.
    Proc Natl Acad Sci U S A. 2024;121:e2312291121.
    PubMed     Abstract available


    January 2024
  19. HULLAHALLI K, Dailey KG, Hasegawa Y, Johnson WE, et al
    Reverse transcriptase inhibitors prevent liver abscess formation during Escherichia coli bloodstream infection.
    Proc Natl Acad Sci U S A. 2024;121:e2319162121.
    PubMed     Abstract available


    December 2023
  20. SAKUMA I, Gaspar RC, Luukkonen PK, Kahn M, et al
    Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
    Proc Natl Acad Sci U S A. 2023;120:e2312666120.
    PubMed     Abstract available


  21. HULLAHALLI K, Dailey KG, Hasegawa Y, Torres E, et al
    Genetic and immune determinants of E. coli liver abscess formation.
    Proc Natl Acad Sci U S A. 2023;120:e2310053120.
    PubMed     Abstract available


    November 2023
  22. YUAN D, Hu J, Ju X, Putz EM, et al
    NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages.
    Proc Natl Acad Sci U S A. 2023;120:e2302126120.
    PubMed     Abstract available


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