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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 46 articles:
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Single Articles


    April 2022
  1. CHENG MT, Chen Y, Chen ZP, Liu X, et al
    Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
    Proc Natl Acad Sci U S A. 2022;119:e2118656119.
    PubMed     Abstract available


    March 2022
  2. KAPS L, Huppertsberg A, Choteschovsky N, Klefenz A, et al
    pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages.
    Proc Natl Acad Sci U S A. 2022;119:e2122310119.
    PubMed     Abstract available


  3. JOUFFE C, Weger BD, Martin E, Atger F, et al
    Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
    Proc Natl Acad Sci U S A. 2022;119:e2200083119.
    PubMed     Abstract available


    January 2022
  4. GAO T, Liu T, Ko CJ, Zhang L, et al
    Myeloid cell TBK1 restricts inflammatory responses.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    November 2021
  5. VASHISTH M, Cho S, Irianto J, Xia Y, et al
    Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  6. HO WW, Gomes-Santos IL, Aoki S, Datta M, et al
    Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021
  7. KAN X, Zhang F, Zhou G, Ji H, et al
    Interventional real-time optical imaging guidance for complete tumor ablation.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  8. DENG J, Yang H, Haak VM, Yang J, et al
    Eicosanoid regulation of debris-stimulated metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  9. LUCERO MY, Tang Y, Zhang CJ, Su S, et al
    Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson's disease and liver metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    July 2021
  10. BUGIDE S, Gupta R, Green MR, Wajapeyee N, et al
    EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  11. NISHIO T, Koyama Y, Liu X, Rosenthal SB, et al
    Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  12. DUCIMETIERE L, Lucchiari G, Litscher G, Nater M, et al
    Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  13. PATEL SJ, Protchenko O, Shakoury-Elizeh M, Baratz E, et al
    The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  14. DARLYUK-SAADON I, Bai C, Heng CKM, Gilad N, et al
    Active p38alpha causes macrovesicular fatty liver in mice.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  15. MULLER K, Honcharova-Biletska H, Koppe C, Egger M, et al
    JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  16. PICCOLO P, Ferriero R, Barbato A, Attanasio S, et al
    Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  17. CHIBAYA L, Karim B, Zhang H, Jones SN, et al
    Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  18. WANG Q, Kim SY, Matsushita H, Wang Z, et al
    Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  19. CONCILLI M, Petruzzelli R, Parisi S, Catalano F, et al
    Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
    Proc Natl Acad Sci U S A. 2020;117:32453-32463.
    PubMed     Abstract available


  20. BAILEY AL, Kang LI, de Assis Barros D'Elia Zanella LGF, Silveira CGT, et al
    Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury.
    Proc Natl Acad Sci U S A. 2020;117:32648-32656.
    PubMed     Abstract available


  21. CHEN W, Li X, Liu C, He J, et al
    beta-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells.
    Proc Natl Acad Sci U S A. 2020;117:30942-30948.
    PubMed     Abstract available


  22. YUEH MF, He F, Chen C, Vu C, et al
    Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:31259-31266.
    PubMed     Abstract available


    November 2020
  23. FLORES-COSTA R, Duran-Guell M, Casulleras M, Lopez-Vicario C, et al
    Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-kappaB/NLRP3 inflammasome circuit.
    Proc Natl Acad Sci U S A. 2020;117:28263-28274.
    PubMed     Abstract available


  24. LIU S, Luttrell LM, Premont RT, Rockey DC, et al
    Reply to Schierwagen et al.: beta-Arrestins in liver disease.
    Proc Natl Acad Sci U S A. 2020;117:27085-27086.
    PubMed    


  25. SCHIERWAGEN R, Dietrich P, Klein S, Uschner FE, et al
    beta-Arrestin2 is increased in liver fibrosis in humans and rodents.
    Proc Natl Acad Sci U S A. 2020;117:27082-27084.
    PubMed    


    October 2020
  26. WANG C, Tang H, Geng A, Dai B, et al
    Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
    Proc Natl Acad Sci U S A. 2020;117:26356-26365.
    PubMed     Abstract available


    September 2020
  27. FISHBEIN A, Wang W, Yang H, Yang J, et al
    Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.
    Proc Natl Acad Sci U S A. 2020;117:21576-21587.
    PubMed     Abstract available


    August 2020
  28. ITATANI Y, Yamamoto T, Zhong C, Molinolo AA, et al
    Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer.
    Proc Natl Acad Sci U S A. 2020 Aug 19. pii: 2008112117.
    PubMed     Abstract available


    July 2020
  29. WU H, Reizel T, Wang YJ, Lapiro JL, et al
    A negative reciprocal regulatory axis between cyclin D1 and HNF4alpha modulates cell cycle progression and metabolism in the liver.
    Proc Natl Acad Sci U S A. 2020;117:17177-17186.
    PubMed     Abstract available


    June 2020
  30. TAN S, Zhao J, Sun Z, Cao S, et al
    Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2020;117:14231-14242.
    PubMed     Abstract available


    May 2020
  31. LIU S, Luttrell LM, Premont RT, Rockey DC, et al
    beta-Arrestin2 is a critical component of the GPCR-eNOS signalosome.
    Proc Natl Acad Sci U S A. 2020;117:11483-11492.
    PubMed     Abstract available


  32. LUTHER J, Khan S, Gala MK, Kedrin D, et al
    Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.
    Proc Natl Acad Sci U S A. 2020;117:11667-11673.
    PubMed     Abstract available


  33. NILSSON A, Haanstra JR, Engqvist M, Gerding A, et al
    Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis.
    Proc Natl Acad Sci U S A. 2020;117:10294-10304.
    PubMed     Abstract available


    April 2020
  34. NOZAKI Y, Petersen MC, Zhang D, Vatner DF, et al
    Metabolic control analysis of hepatic glycogen synthesis in vivo.
    Proc Natl Acad Sci U S A. 2020;117:8166-8176.
    PubMed     Abstract available


    March 2020
  35. LUUKKONEN PK, Dufour S, Lyu K, Zhang XM, et al
    Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:7347-7354.
    PubMed     Abstract available


  36. LIU M, Yan Q, Sun Y, Nam Y, et al
    A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.
    Proc Natl Acad Sci U S A. 2020;117:6103-6113.
    PubMed     Abstract available


  37. JIANG H, Cao HJ, Ma N, Bao WD, et al
    Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.
    Proc Natl Acad Sci U S A. 2020;117:4770-4780.
    PubMed     Abstract available


    January 2020
  38. WOOTON-KEE CR, Robertson M, Zhou Y, Dong B, et al
    Metabolic dysregulation in the Atp7b (-/-) Wilson's disease mouse model.
    Proc Natl Acad Sci U S A. 2020;117:2076-2083.
    PubMed     Abstract available


  39. WINKLER I, Bitter C, Winkler S, Weichenhan D, et al
    Identification of Ppargamma-modulated miRNA hubs that target the fibrotic tumor microenvironment.
    Proc Natl Acad Sci U S A. 2020;117:454-463.
    PubMed     Abstract available


    October 2019
  40. TRUONG B, Allegri G, Liu XB, Burke KE, et al
    Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
    Proc Natl Acad Sci U S A. 2019;116:21150-21159.
    PubMed     Abstract available


    September 2019
  41. LIU K, Theusch E, Zhou Y, Ashuach T, et al
    GeneFishing to reconstruct context specific portraits of biological processes.
    Proc Natl Acad Sci U S A. 2019;116:18943-18950.
    PubMed     Abstract available


    July 2019
  42. KINGSTON BR, Syed AM, Ngai J, Sindhwani S, et al
    Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning.
    Proc Natl Acad Sci U S A. 2019;116:14937-14946.
    PubMed     Abstract available


  43. WANG L, Mazagova M, Pan C, Yang S, et al
    YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
    Proc Natl Acad Sci U S A. 2019 Jul 9. pii: 1904360116.
    PubMed     Abstract available


  44. HUA G, Zein N, Paulen L, Chambon P, et al
    The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids.
    Proc Natl Acad Sci U S A. 2019;116:14200-14209.
    PubMed     Abstract available


  45. TORRES C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, et al
    p110gamma deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.
    Proc Natl Acad Sci U S A. 2019 Jul 2. pii: 1813012116.
    PubMed     Abstract available


  46. MIYAUCHI T, Uchida Y, Kadono K, Hirao H, et al
    Up-regulation of FOXO1 and reduced inflammation by beta-hydroxybutyric acid are essential diet restriction benefits against liver injury.
    Proc Natl Acad Sci U S A. 2019;116:13533-13542.
    PubMed     Abstract available


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