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Lung Cancer

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 64 articles: HTML format

Single Articles

August 2026
1. DU H, Lang T, Zha X, Qu C, et al
   Single-cell multiomics identifies an ALDH9A1-carnitine signaling axis driving resistance of NSCLC to immunotherapy.
   Proc Natl Acad Sci U S A. 2026;123:e2535328123.
   PubMed     Abstract available
   
   
   July 2026
2. LIU N, Han G, Zhang F, Gu Q, et al
   TMED9 drives non-small-cell lung cancer progression via promotion of autophagy by recruiting USP5 to deubiquitinate ATG9A.
   Proc Natl Acad Sci U S A. 2026;123:e2532259123.
   PubMed     Abstract available
   
   
   June 2026
3. LI G, Li Q, Zhang J, Huang Y, et al
   p53 overrides METTL5 loss-induced tumor suppression via mitochondrial respiration.
   Proc Natl Acad Sci U S A. 2026;123:e2604695123.
   PubMed     Abstract available
   
   
   
4. KIELISZEK AM, Apel E, Zheng S, Piotrowski M, et al
   Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function.
   Proc Natl Acad Sci U S A. 2026;123:e2603440123.
   PubMed     Abstract available
   
   
   
5. ZHANG J, Liu R, Han X, Jiao Y, et al
   High-throughput screening identifies a critical role of the SPOP-PABPC1 axis in lung adenocarcinoma progression.
   Proc Natl Acad Sci U S A. 2026;123:e2602470123.
   PubMed     Abstract available
   
   
   
6. YUAN J, Ma Y, Dong Y, Zhang Z, et al
   Targeting XIAP-coordinated PKC signaling resensitizes PD-1-refractory tumors for rechallenge.
   Proc Natl Acad Sci U S A. 2026;123:e2600501123.
   PubMed     Abstract available
   
   
   May 2026
7. FREITAG KM, Scheuplein R, Orlacchio C, Ansuinelli V, et al
   Light-controlled disruption of cancer cell dormancy via photoswitchable stress hormone receptor degraders.
   Proc Natl Acad Sci U S A. 2026;123:e2528760123.
   PubMed     Abstract available
   
   
   
8. HE J, Lok CN, Yang G, He Y, et al
   A ginsenoside metabolite and its derivative target PRELID3B against lung cancer cells.
   Proc Natl Acad Sci U S A. 2026;123:e2533505123.
   PubMed     Abstract available
   
   
   
9. GARRIDO A, Tamayo-Torres E, Abdo S, Durham E, et al
   The antimetastatic effects of calorie restriction are negated by voluntary exercise in an aggressive breast cancer mouse model.
   Proc Natl Acad Sci U S A. 2026;123:e2524488123.
   PubMed     Abstract available
   
   
   April 2026
10. ROBAY D, Ackermann O, Laborde L, Shi X, et al
    Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.
    Proc Natl Acad Sci U S A. 2026;123:e2508762123.
    PubMed     Abstract available
    
    
    
11. FARIAS A, Bridgeman VL, Rodrigues FS, Puttur F, et al
    Type I interferons induced upon respiratory viral infection impair lung metastatic initiation.
    Proc Natl Acad Sci U S A. 2026;123:e2412919123.
    PubMed     Abstract available
    
    
    March 2026
12. ABT ER, Wang L, Varuzhanyan G, Freeland J, et al
    Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade.
    Proc Natl Acad Sci U S A. 2026;123:e2532814123.
    PubMed     Abstract available
    
    
    
13. NIKOLIC J, Ackermann J, Marin I, Taheraly S, et al
    Adhesion forces between macrophages and cancer cells promote early tumor development.
    Proc Natl Acad Sci U S A. 2026;123:e2514484123.
    PubMed     Abstract available
    
    
    February 2026
14. 
    Correction for Impheng et al., Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells.
    Proc Natl Acad Sci U S A. 2026;123:e2602974123.
    PubMed    
    
    
    
15. YANG Y, Wang S, Shi X, Chen X, et al
    Intravenous infusion of engineered megakaryocytes to produce oncolytic platelets in vivo for enhanced cancer immunotherapy.
    Proc Natl Acad Sci U S A. 2026;123:e2419694123.
    PubMed     Abstract available
    
    
    
16. TENDLER S, De Gregorio R, Balderes P, Michel AL, et al
    Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers.
    Proc Natl Acad Sci U S A. 2026;123:e2505785123.
    PubMed     Abstract available
    
    
    January 2026
17. IMPHENG H, Gillard G, Numnoi N, Feral A, et al
    Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells.
    Proc Natl Acad Sci U S A. 2026;123:e2514990123.
    PubMed     Abstract available
    
    
    December 2025
18. WANG X, Sun J, Lan B, Wang C, et al
    Asparagine endopeptidase prompts breast cancer-related pericardial calcification by regulating IGF2 and integrin alphavbeta5.
    Proc Natl Acad Sci U S A. 2025;122:e2512936122.
    PubMed     Abstract available
    
    
    November 2025
19. KLOSOWSKI ML, Cronise KE, Palmer EP, McAuliffe K, et al
    Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2423894122.
    PubMed     Abstract available
    
    
    
20. CUI H, Cai X, Qian Q, Fan S, et al
    ZDHHC11-mediated AXL palmitoylation promotes osimertinib resistance in non-small-cell lung cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2502778122.
    PubMed     Abstract available
    
    
    October 2025
21. SCHULTZ CW, Saha S, Dhall A, Zhang Y, et al
    Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2503387122.
    PubMed     Abstract available
    
    
    
22. CHEN S, Zhong M, Wang X, Su Y, et al
    Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2509255122.
    PubMed     Abstract available
    
    
    September 2025
23. ZHANG J, Zhang J, Han L, Wu S, et al
    Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state.
    Proc Natl Acad Sci U S A. 2025;122:e2515009122.
    PubMed     Abstract available
    
    
    August 2025
24. MASO L, Rajak E, Hattori T, Hu Z, et al
    Generation of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib.
    Proc Natl Acad Sci U S A. 2025;122:e2509012122.
    PubMed     Abstract available
    
    
    July 2025
25. TAN X, Cardin DL, Wang S, Xu Y, et al
    Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4.
    Proc Natl Acad Sci U S A. 2025;122:e2501347122.
    PubMed     Abstract available
    
    
    
26. BARNET MB, Jackson KJL, Masle-Farquhar E, Russell A, et al
    Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy.
    Proc Natl Acad Sci U S A. 2025;122:e2314258122.
    PubMed     Abstract available
    
    
    June 2025
27. JEONG D, Park SH, Kim J, Kim H, et al
    Tumor-promoting UBR4 coordinates impaired mitophagy-associated senescence and lung adenocarcinoma pathogenesis.
    Proc Natl Acad Sci U S A. 2025;122:e2425015122.
    PubMed     Abstract available
    
    
    
28. WANG M, Wang Y, Pan X, Wang B, et al
    Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2500019122.
    PubMed     Abstract available
    
    
    
29. GORELIK A, Paulo JA, Schroeter CB, Lad M, et al
    CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor-driven proteome through PARP7 activity.
    Proc Natl Acad Sci U S A. 2025;122:e2424985122.
    PubMed     Abstract available
    
    
    May 2025
30. WANG H, Huang J, Zhang Z, An Y, et al
    Phase separation of RXRgamma drives tumor chemoresistance and represents a therapeutic target for small-cell lung cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2421199122.
    PubMed     Abstract available
    
    
    
31. JIAO Z, Zhang M, Ning J, Yao H, et al
    The oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity.
    Proc Natl Acad Sci U S A. 2025;122:e2412854122.
    PubMed     Abstract available
    
    
    April 2025
32. GONG JR, Lee J, Han Y, Cho KH, et al
    DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden.
    Proc Natl Acad Sci U S A. 2025;122:e2412310122.
    PubMed     Abstract available
    
    
    
33. YIN L, Zhang J, Zhu Z, Peng X, et al
    The FBXW7-KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanism.
    Proc Natl Acad Sci U S A. 2025;122:e2423130122.
    PubMed     Abstract available
    
    
    March 2025
34. BALTANAS FC, Kramer-Drauberg M, Garcia-Navas R, Patrucco E, et al
    SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRAS(G12D) inhibitor in KRAS LUAD.
    Proc Natl Acad Sci U S A. 2025;122:e2422943122.
    PubMed     Abstract available
    
    
    
35. SAXENA T, Quan A, Chan E, Kozlova N, et al
    EGFR-induced lncRNA TRIDENT promotes drug resistance in non-small cell lung cancer via phospho-TRIM28-mediated DNA damage repair.
    Proc Natl Acad Sci U S A. 2025;122:e2415389122.
    PubMed     Abstract available
    
    
    January 2025
36. ZHANG Y, Wang X, Gu Y, Liu T, et al
    Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells.
    Proc Natl Acad Sci U S A. 2025;122:e2420005122.
    PubMed     Abstract available
    
    
    December 2024
37. MEI J, Jiang J, Li Z, Pan Y, et al
    Increased perfluorooctanoic acid accumulation facilitates the migration and invasion of lung cancer cells via remodeling cell mechanics.
    Proc Natl Acad Sci U S A. 2024;121:e2408575121.
    PubMed     Abstract available
    
    
    
38. CHEN J, Wang T, Zhang D, Wang H, et al
    KDM5D histone demethylase mediates p38alpha inactivation via its enzymatic activity to inhibit cancer progression.
    Proc Natl Acad Sci U S A. 2024;121:e2402022121.
    PubMed     Abstract available
    
    
    November 2024
39. ZHAO H, Beyett TS, Jiang J, Rana JK, et al
    Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity.
    Proc Natl Acad Sci U S A. 2024;121:e2417144121.
    PubMed     Abstract available
    
    
    October 2024
40. ZHU J, Du W, Zeng Y, Liu T, et al
    CD73 promotes non-small cell lung cancer metastasis by regulating Axl signaling independent of GAS6.
    Proc Natl Acad Sci U S A. 2024;121:e2404709121.
    PubMed     Abstract available
    
    
    
41. MCGUIRE CK, Meehan AS, Couser E, Bull L, et al
    Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors.
    Proc Natl Acad Sci U S A. 2024;121:e2317694121.
    PubMed     Abstract available
    
    
    
42. DAVIS E, Avniel-Polak S, Abu-Kamel S, Antman I, et al
    Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications.
    Proc Natl Acad Sci U S A. 2024;121:e2405001121.
    PubMed     Abstract available
    
    
    September 2024
43. FUJIWARA Y, Takahashi RU, Saito M, Umakoshi M, et al
    Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma.
    Proc Natl Acad Sci U S A. 2024;121:e2407016121.
    PubMed     Abstract available
    
    
    
44. FERNANDEZ-GARCIA F, Fernandez-Rodriguez A, Fustero-Torre C, Pineiro-Yanez E, et al
    Type I interferon signaling pathway enhances immune-checkpoint inhibition in KRAS mutant lung tumors.
    Proc Natl Acad Sci U S A. 2024;121:e2402913121.
    PubMed     Abstract available
    
    
    July 2024
45. SHAN L, Wang W, Du L, Li D, et al
    SP1 undergoes phase separation and activates RGS20 expression through super-enhancers to promote lung adenocarcinoma progression.
    Proc Natl Acad Sci U S A. 2024;121:e2401834121.
    PubMed     Abstract available
    
    
    
46. LARA-SAEZ I, Mencia A, Recuero E, Li Y, et al
    Nonviral CRISPR/Cas9 mutagenesis for streamlined generation of mouse lung cancer models.
    Proc Natl Acad Sci U S A. 2024;121:e2322917121.
    PubMed     Abstract available
    
    
    June 2024
47. KUMARI P, Tarighi S, Fuchshuber E, Li L, et al
    SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF.
    Proc Natl Acad Sci U S A. 2024;121:e2409269121.
    PubMed     Abstract available
    
    
    
48. RUAN ML, Ni WX, Chu JCH, Lam TL, et al
    Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers.
    Proc Natl Acad Sci U S A. 2024;121:e2316615121.
    PubMed     Abstract available
    
    
    
49. YANG C, Ma S, Zhang J, Han Y, et al
    EHMT2-mediated transcriptional reprogramming drives neuroendocrine transformation in non-small cell lung cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2317790121.
    PubMed     Abstract available
    
    
    May 2024
50. FERRARONE JR, Thomas J, Unni AM, Zheng Y, et al
    Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.
    Proc Natl Acad Sci U S A. 2024;121:e2403685121.
    PubMed     Abstract available
    
    
    
51. DONG Z, Wang Y, Xu G, Liu B, et al
    Genetic and phenotypic profiling of single living circulating tumor cells from patients with microfluidics.
    Proc Natl Acad Sci U S A. 2024;121:e2315168121.
    PubMed     Abstract available
    
    
    
52. DUTT P, Haider N, Mouaaz S, Podmore L, et al
    beta-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.
    Proc Natl Acad Sci U S A. 2024;121:e2300606121.
    PubMed     Abstract available
    
    
    March 2024
53. HAN X, Wang D, Yang L, Wang N, et al
    Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2319429121.
    PubMed     Abstract available
    
    
    February 2024
54. JANSEN RA, Mainardi S, Dias MH, Bosma A, et al
    Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers.
    Proc Natl Acad Sci U S A. 2024;121:e2319492121.
    PubMed     Abstract available
    
    
    January 2024
55. CHEN NY, Lin CW, Lai TY, Wu CY, et al
    Increased expression of SSEA-4 on TKI-resistant non-small cell lung cancer with EGFR-T790M mutation.
    Proc Natl Acad Sci U S A. 2024;121:e2313397121.
    PubMed     Abstract available
    
    
    
56. WU XN, Li JY, He Q, Li BQ, et al
    Targeting the PHF8/YY1 axis suppresses cancer cell growth through modulation of ROS.
    Proc Natl Acad Sci U S A. 2024;121:e2219352120.
    PubMed     Abstract available
    
    
    December 2023
57. LEE H, Jung JH, Ko HM, Park H, et al
    RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5.
    Proc Natl Acad Sci U S A. 2023;120:e2308292120.
    PubMed     Abstract available
    
    
    October 2023
58. CHUNG YH, Ortega-Rivera OA, Volckaert BA, Jung E, et al
    Viral nanoparticle vaccines against S100A9 reduce lung tumor seeding and metastasis.
    Proc Natl Acad Sci U S A. 2023;120:e2221859120.
    PubMed     Abstract available
    
    
    
59. IM SJ, Obeng RC, Nasti TH, McManus D, et al
    Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer.
    Proc Natl Acad Sci U S A. 2023;120:e2221985120.
    PubMed     Abstract available
    
    
    
60. GINN L, Maltas J, Baker MJ, Chaturvedi A, et al
    A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells.
    Proc Natl Acad Sci U S A. 2023;120:e2300489120.
    PubMed     Abstract available
    
    
    September 2023
61. SUAREZ JS, Novelli F, Goto K, Ehara M, et al
    HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.
    Proc Natl Acad Sci U S A. 2023;120:e2307999120.
    PubMed     Abstract available
    
    
    
62. CHEN Y, Shi J, Wang X, Zhou L, et al
    An antioxidant feedforward cycle coordinated by linker histone variant H1.2 and NRF2 that drives nonsmall cell lung cancer progression.
    Proc Natl Acad Sci U S A. 2023;120:e2306288120.
    PubMed     Abstract available
    
    
    
63. LIN X, Chen Y, Lin L, Yin K, et al
    mitoSplitter: A mitochondrial variants-based method for efficient demultiplexing of pooled single-cell RNA-seq.
    Proc Natl Acad Sci U S A. 2023;120:e2307722120.
    PubMed     Abstract available
    
    
    
64. YOUSEFI M, Andrejka L, Szamecz M, Winslow MM, et al
    Fully accessible fitness landscape of oncogene-negative lung adenocarcinoma.
    Proc Natl Acad Sci U S A. 2023;120:e2303224120.
    PubMed     Abstract available
    
    

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