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COVID Reference, 4th edition, 372 pages

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  Obstructive Lung Diseases

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Articles published in N Engl J Med

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Single Articles


    July 2020
  1. RABE KF, Martinez FJ, Ferguson GT, Wang C, et al
    Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD.
    N Engl J Med. 2020;383:35-48.
    PubMed     Abstract available


    May 2020
  2. CREEL-BULOS C, Hockstein M, Amin N, Melhem S, et al
    Acute Cor Pulmonale in Critically Ill Patients with Covid-19.
    N Engl J Med. 2020 May 6. doi: 10.1056/NEJMc2010459.
    PubMed    


    April 2020
  3. KESSLER M, Reinig E
    HLH Associated with Disseminated Tuberculosis.
    N Engl J Med. 2020;382:1749.
    PubMed    


  4. ROSE C
    Am I Part of the Cure or Am I Part of the Disease? Keeping Coronavirus Out When a Doctor Comes Home.
    N Engl J Med. 2020;382:1684-1685.
    PubMed    


  5. FINKS SW, Rumbak MJ, Self TH
    Hypertension in Chronic Obstructive Pulmonary Disease. Reply.
    N Engl J Med. 2020;382:1674.
    PubMed    


  6. MEHMOOD M
    Hypertension in Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2020;382:1674.
    PubMed    


  7. WERNER AK, Koumans EH, Chatham-Stephens K, Salvatore PP, et al
    Hospitalizations and Deaths Associated with EVALI.
    N Engl J Med. 2020;382:1589-1598.
    PubMed     Abstract available


  8. GODSON C
    Balancing the Effect of Leukotrienes in Asthma.
    N Engl J Med. 2020;382:1472-1475.
    PubMed    


  9. MCELVANEY OJ, Carroll TP, Franciosi AN, Sweeney J, et al
    Consequences of Abrupt Cessation of Alpha1-Antitrypsin Replacement Therapy.
    N Engl J Med. 2020;382:1478-1480.
    PubMed    


  10. STRNAD P, McElvaney NG, Lomas DA
    Alpha1-Antitrypsin Deficiency.
    N Engl J Med. 2020;382:1443-1455.
    PubMed    


  11. DRANSFIELD MT, Helgeson ES, Connett JE
    Metoprolol for the Prevention of Exacerbations of COPD. Reply.
    N Engl J Med. 2020;382:1375-1376.
    PubMed    


  12. MEHMOOD M
    Metoprolol for the Prevention of Exacerbations of COPD.
    N Engl J Med. 2020;382:1375.
    PubMed    


  13. DOUMAS M, Imprialos KP, Stavropoulos K
    Metoprolol for the Prevention of Exacerbations of COPD.
    N Engl J Med. 2020;382:1374-1375.
    PubMed    


  14. REESE Z, Ganatra RB
    Metoprolol for the Prevention of Exacerbations of COPD.
    N Engl J Med. 2020;382:1374.
    PubMed    


    March 2020
  15. BHATRAJU PK, Ghassemieh BJ, Nichols M, Kim R, et al
    Covid-19 in Critically Ill Patients in the Seattle Region - Case Series.
    N Engl J Med. 2020 Mar 30. doi: 10.1056/NEJMoa2004500.
    PubMed     Abstract available


    February 2020
  16. VON MUTIUS E, Martinez FD
    Vitamin D Supplementation during Pregnancy and the Prevention of Childhood Asthma.
    N Engl J Med. 2020;382:574-575.
    PubMed    


  17. LITONJUA AA, Carey VJ, Laranjo N, Stubbs BJ, et al
    Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction.
    N Engl J Med. 2020;382:525-533.
    PubMed     Abstract available


    January 2020
  18. WECHSLER ME, Ortega VE, Israel E
    Step-Up Therapy in Black Patients with Asthma. Reply.
    N Engl J Med. 2020;382:391-392.
    PubMed    


  19. LIPWORTH B, Chan R, Kuo CR
    Step-Up Therapy in Black Patients with Asthma.
    N Engl J Med. 2020;382:391.
    PubMed    


  20. MERCKX J, Kaufman JS, Cooper RS
    Step-Up Therapy in Black Patients with Asthma.
    N Engl J Med. 2020;382:390-391.
    PubMed    


  21. KESH S, Jones BL
    Step-Up Therapy in Black Patients with Asthma.
    N Engl J Med. 2020;382:390.
    PubMed    


  22. FINKS SW, Rumbak MJ, Self TH
    Treating Hypertension in Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2020;382:353-363.
    PubMed    


  23. SALEH Y, Alratroot A
    Crepitus and Subcutaneous Emphysema.
    N Engl J Med. 2020;382:e1.
    PubMed    


    December 2019
  24. CELLI BR, Wedzicha JA
    Update on Clinical Aspects of COPD. Reply.
    N Engl J Med. 2019;381:2485-2486.
    PubMed    


  25. OROZCO-HERNANDEZ JP, Pacheco-Gallego M, Montoya-Martinez JJ
    Update on Clinical Aspects of COPD.
    N Engl J Med. 2019;381:2485.
    PubMed    


  26. XIONG W, Guo X
    Update on Clinical Aspects of COPD.
    N Engl J Med. 2019;381:2485.
    PubMed    


  27. CONTRERAS-GARZA BM
    Update on Clinical Aspects of COPD.
    N Engl J Med. 2019;381:2484-2485.
    PubMed    


  28. AGUSTI A, Hogg JC
    Update on the Pathogenesis of COPD. Reply.
    N Engl J Med. 2019;381:2484.
    PubMed    


  29. EAPEN MS, Sohal SS
    Update on the Pathogenesis of COPD.
    N Engl J Med. 2019;381:2483-2484.
    PubMed    


  30. BUTLER CC, Gillespie D, Francis NA
    C-Reactive Protein for Antibiotic Use in COPD Exacerbations. Reply.
    N Engl J Med. 2019;381:2372.
    PubMed    


  31. YILDIZ H
    C-Reactive Protein for Antibiotic Use in COPD Exacerbations.
    N Engl J Med. 2019;381:2371-2372.
    PubMed    


  32. VERBAKEL JY, Van den Bruel A, Thompson M
    C-Reactive Protein for Antibiotic Use in COPD Exacerbations.
    N Engl J Med. 2019;381:2371.
    PubMed    


  33. GLINZ D
    C-Reactive Protein for Antibiotic Use in COPD Exacerbations.
    N Engl J Med. 2019;381:2371.
    PubMed    


  34. MACNEE W
    Beta-Blockers in COPD - A Controversy Resolved?
    N Engl J Med. 2019;381:2367-2368.
    PubMed    


  35. DRANSFIELD MT, Voelker H, Bhatt SP, Brenner K, et al
    Metoprolol for the Prevention of Acute Exacerbations of COPD.
    N Engl J Med. 2019;381:2304-2314.
    PubMed     Abstract available


  36. CHRISTIANSEN SC, Zuraw BL
    Treatment of Hypertension in Patients with Asthma. Reply.
    N Engl J Med. 2019;381:2279.
    PubMed    


  37. LIN CH
    Treatment of Hypertension in Patients with Asthma.
    N Engl J Med. 2019;381:2278-2279.
    PubMed    


    September 2019
  38. WECHSLER ME, Szefler SJ, Ortega VE, Pongracic JA, et al
    Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.
    N Engl J Med. 2019;381:1227-1239.
    PubMed     Abstract available


  39. CELLI BR, Wedzicha JA
    Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2019;381:1257-1266.
    PubMed    


  40. AGUSTI A, Hogg JC
    Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2019;381:1248-1256.
    PubMed    


  41. CHRISTIANSEN SC, Zuraw BL
    Treatment of Hypertension in Patients with Asthma.
    N Engl J Med. 2019;381:1046-1057.
    PubMed    


  42. KREMER TM, Lindsay ME, Kinane TB, Hawley MH, et al
    Case 28-2019: A 22-Year-Old Woman with Dyspnea and Chest Pain.
    N Engl J Med. 2019;381:1059-1067.
    PubMed    


  43. CRINER GJ, Celli BR, Brightling CE, Agusti A, et al
    Benralizumab for the Prevention of COPD Exacerbations.
    N Engl J Med. 2019;381:1023-1034.
    PubMed     Abstract available


  44. BOUCHER RC
    Muco-Obstructive Lung Diseases. Reply.
    N Engl J Med. 2019;381:e20.
    PubMed    


  45. BOYTON RJ, Altmann DM
    Muco-Obstructive Lung Diseases.
    N Engl J Med. 2019;381:e20.
    PubMed    


  46. MOST JF
    Muco-Obstructive Lung Diseases.
    N Engl J Med. 2019;381:e20.
    PubMed    


    August 2019
  47. FAHY JV, Locksley RM
    Making Asthma Crystal Clear.
    N Engl J Med. 2019;381:882-884.
    PubMed    


  48. MHAMDI S, Mhamdi K
    Emphysematous Cholecystitis.
    N Engl J Med. 2019;381:e14.
    PubMed    


  49. WARREN O
    Mike's Labels.
    N Engl J Med. 2019;381:600-601.
    PubMed    


    July 2019
  50. BRETT AS, Al-Hasan MN
    COPD Exacerbations - A Target for Antibiotic Stewardship.
    N Engl J Med. 2019;381:174-175.
    PubMed    


  51. BUTLER CC, Gillespie D, White P, Bates J, et al
    C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations.
    N Engl J Med. 2019;381:111-120.
    PubMed     Abstract available


    May 2019
  52. BEASLEY R, Holliday M, Reddel HK, Braithwaite I, et al
    Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma.
    N Engl J Med. 2019;380:2020-2030.
    PubMed     Abstract available


  53. LAZARUS SC, Krishnan JA, King TS, Lang JE, et al
    Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
    N Engl J Med. 2019;380:2009-2019.
    PubMed     Abstract available


  54. WONG GWK
    How Should We Treat Patients with Mild Asthma?
    N Engl J Med. 2019;380:2064-2066.
    PubMed    


  55. BOUCHER RC
    Muco-Obstructive Lung Diseases.
    N Engl J Med. 2019;380:1941-1953.
    PubMed    


    April 2019

  56. Tezepelumab in Adults with Uncontrolled Asthma.
    N Engl J Med. 2019 Apr 18. doi: 10.1056/NEJMx180026.
    PubMed    


  57. ST CLAIR TM, Zwemer E
    Diffuse Subcutaneous Emphysema.
    N Engl J Med. 2019;380:e20.
    PubMed    


  58. NOROSKI L, Das S, Hajjar J
    Case 40-2018: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.
    N Engl J Med. 2019;380:1383.
    PubMed    


  59. BASTARACHE L, Bastarache JA, Denny JC
    Case 40-2018: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.
    N Engl J Med. 2019;380:1382-1383.
    PubMed    


    December 2018
  60. MOJICA JE, Richards CJ, Husseini JS, Hariri LP, et al
    Case 40-2018: A 47-Year-Old Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.
    N Engl J Med. 2018;379:2558-2565.
    PubMed    


    October 2018
  61. WEINBERGER M
    Safety Trials of Long-Acting beta2-Agonists.
    N Engl J Med. 2018;379:1481-2.
    PubMed    


  62. BUSSE WW
    Safety Trials of Long-Acting beta2-Agonists.
    N Engl J Med. 2018;379:1482.
    PubMed    


    August 2018

  63. As-Needed Budesonide-Formoterol in Mild Asthma.
    N Engl J Med. 2018;379:897-898.
    PubMed    


  64. CAO C, Kong X
    As-Needed Budesonide-Formoterol in Mild Asthma.
    N Engl J Med. 2018;379:897-8.
    PubMed    


  65. PETITE SE
    Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
    N Engl J Med. 2018;379:591-2.
    PubMed    


  66. WEDZICHA JA, Banerji D, Kostikas K
    Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
    N Engl J Med. 2018;379:591.
    PubMed    


  67. ROLLA G, Brussino L
    Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
    N Engl J Med. 2018;379:590-1.
    PubMed    



  68. Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
    N Engl J Med. 2018;379:590-593.
    PubMed    


    July 2018
  69. LLOYD CM, Harker JA
    Epigenetic Control of Interleukin-9 in Asthma.
    N Engl J Med. 2018;379:87-89.
    PubMed    


    June 2018
  70. BUSSE WW, Bateman ED, Caplan AL, Kelly HW, et al
    Combined Analysis of Asthma Safety Trials of Long-Acting beta2-Agonists.
    N Engl J Med. 2018;378:2497-2505.
    PubMed     Abstract available


  71. LINSSEN RS, van Woensel JB, Bont L
    High-Flow Oxygen Therapy in Infants with Bronchiolitis.
    N Engl J Med. 2018;378:2445-6.
    PubMed    


  72. DE BENEDICTIS FM, Cogo P
    High-Flow Oxygen Therapy in Infants with Bronchiolitis.
    N Engl J Med. 2018;378:2444-5.
    PubMed    


  73. ALAPONT VMI, Garcia Cusco M, Medina A
    High-Flow Oxygen Therapy in Infants with Bronchiolitis.
    N Engl J Med. 2018;378:2444.
    PubMed    


  74. MESKILL SD, Moore RH
    High-Flow Oxygen Therapy in Infants with Bronchiolitis.
    N Engl J Med. 2018;378:2444.
    PubMed    



  75. High-Flow Oxygen Therapy in Infants with Bronchiolitis.
    N Engl J Med. 2018;378:2444-2447.
    PubMed    



  76. Effect of Bronchoconstriction on Airway Remodeling in Asthma.
    N Engl J Med. 2018 Jun 13. doi: 10.1056/NEJMx180023.
    PubMed    


    May 2018
  77. BOULET LP, Gupta S, FitzGerald JM
    Inhaled Glucocorticoids in Asthma.
    N Engl J Med. 2018;378:2050-1.
    PubMed    


  78. MORJARIA JB
    Inhaled Glucocorticoids in Asthma.
    N Engl J Med. 2018;378:2050.
    PubMed    


  79. GERALD JK
    Inhaled Glucocorticoids in Asthma.
    N Engl J Med. 2018;378:2049-50.
    PubMed    



  80. Inhaled Glucocorticoids in Asthma.
    N Engl J Med. 2018;378:2049-2052.
    PubMed    


  81. BARDIN PG
    Inhaled Glucocorticoids in Asthma.
    N Engl J Med. 2018;378:2052.
    PubMed    


  82. HARRISON T, Bradshaw L, McKeever T
    Inhaled Glucocorticoids in Asthma.
    N Engl J Med. 2018;378:2051-2052.
    PubMed    


  83. DRAZEN JM, Harrington D
    New Biologics for Asthma.
    N Engl J Med. 2018 May 21. doi: 10.1056/NEJMe1806037.
    PubMed    


  84. RABE KF, Nair P, Brusselle G, Maspero JF, et al
    Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.
    N Engl J Med. 2018 May 21. doi: 10.1056/NEJMoa1804093.
    PubMed     Abstract available


  85. CASTRO M, Corren J, Pavord ID, Maspero J, et al
    Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.
    N Engl J Med. 2018 May 21. doi: 10.1056/NEJMoa1804092.
    PubMed     Abstract available


  86. O'BYRNE PM, FitzGerald JM, Bateman ED, Barnes PJ, et al
    Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma.
    N Engl J Med. 2018;378:1865-1876.
    PubMed     Abstract available


  87. BATEMAN ED, Reddel HK, O'Byrne PM, Barnes PJ, et al
    As-Needed Budesonide-Formoterol versus Maintenance Budesonide in Mild Asthma.
    N Engl J Med. 2018;378:1877-1887.
    PubMed     Abstract available


  88. LAZARUS SC
    On-Demand versus Maintenance Inhaled Treatment in Mild Asthma.
    N Engl J Med. 2018;378:1940-1942.
    PubMed    


  89. SUISSA S, Drazen JM
    Making Sense of Triple Inhaled Therapy for COPD.
    N Engl J Med. 2018;378:1723-1724.
    PubMed    


  90. LIPSON DA, Barnhart F, Brealey N, Brooks J, et al
    Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
    N Engl J Med. 2018;378:1671-1680.
    PubMed     Abstract available


    March 2018
  91. FRANKLIN D, Babl FE, Schlapbach LJ, Oakley E, et al
    A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis.
    N Engl J Med. 2018;378:1121-1131.
    PubMed     Abstract available


  92. BARDIN PG
    Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations.
    N Engl J Med. 2018;378:950-952.
    PubMed    


  93. MCKEEVER T, Mortimer K, Wilson A, Walker S, et al
    Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations.
    N Engl J Med. 2018;378:902-910.
    PubMed     Abstract available


  94. JACKSON DJ, Bacharier LB, Mauger DT, Boehmer S, et al
    Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations.
    N Engl J Med. 2018;378:891-901.
    PubMed     Abstract available


    February 2018
  95. SHAHLAVIMONAVVAR P, Mobasher-Jannat A
    Mepolizumab for Eosinophilic COPD.
    N Engl J Med. 2018;378:681.
    PubMed    


  96. XIA Y, Li W, Shen H
    Mepolizumab for Eosinophilic COPD.
    N Engl J Med. 2018;378:680-1.
    PubMed    


  97. SCIURBA FC, Bradford ES, Pavord ID
    Mepolizumab for Eosinophilic COPD.
    N Engl J Med. 2018;378:681-683.
    PubMed    


    December 2017
  98. GARRISON SR, Allan GM
    Tiotropium in Early-Stage COPD.
    N Engl J Med. 2017;377:2293.
    PubMed    


  99. KERWIN E
    Tiotropium in Early-Stage COPD.
    N Engl J Med. 2017;377:2292-3.
    PubMed    


  100. QIAN G, Ying F, Li G
    Tiotropium in Early-Stage COPD.
    N Engl J Med. 2017;377:2292.
    PubMed    



  101. Tiotropium in Early-Stage COPD.
    N Engl J Med. 2017;377:2292-2294.
    PubMed    


    October 2017
  102. MCDONALD CF
    Eosinophil Biology in COPD.
    N Engl J Med. 2017;377:1680-1682.
    PubMed    


  103. PAVORD ID, Chanez P, Criner GJ, Kerstjens HAM, et al
    Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2017;377:1613-1629.
    PubMed     Abstract available


    September 2017
  104. AKTAS OO, Sekerel BE, Fuat Kalyoncu A
    Glucocorticoid Sparing of Benralizumab in Asthma.
    N Engl J Med. 2017;377:1203-4.
    PubMed    


  105. CAO C, Kong X, Huang X
    Glucocorticoid Sparing of Benralizumab in Asthma.
    N Engl J Med. 2017;377:1205.
    PubMed    



  106. Glucocorticoid Sparing of Benralizumab in Asthma.
    N Engl J Med. 2017;377:1204-1205.
    PubMed    


  107. KO FWS, Wong GWK
    Drug Treatment for Early-Stage COPD.
    N Engl J Med. 2017;377:988-989.
    PubMed    


  108. WEDZICHA JA
    Airway Mucins in Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2017;377:986-987.
    PubMed    


  109. ZHOU Y, Zhong NS, Li X, Chen S, et al
    Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease.
    N Engl J Med. 2017;377:923-935.
    PubMed     Abstract available


  110. KESIMER M, Ford AA, Ceppe A, Radicioni G, et al
    Airway Mucin Concentration as a Marker of Chronic Bronchitis.
    N Engl J Med. 2017;377:911-922.
    PubMed     Abstract available


    May 2017
  111. DJUKANOVIC R, O'Byrne PM
    Targeting Eosinophils in Eosinophilic Granulomatosis with Polyangiitis.
    N Engl J Med. 2017;376:1985-1986.
    PubMed    


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