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Articles published in Ann Neurol

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Single Articles


    January 2026
  1. FAN Z, Searle G, Rizzo G, Albani J, et al
    Toward Harmonizing Quantification of Dopamine Neuron Imaging Biomarkers in Parkinson's Disease: The Centamine Scale.
    Ann Neurol. 2026 Jan 20. doi: 10.1002/ana.78116.
    PubMed     Abstract available


  2. HAJJI-LOUATI M, Correia E, Lee PC, Artaud F, et al
    Adherence to the Mediterranean and Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diets and Parkinson's Disease Incidence in Women: Results from the Prospective E3N Cohort.
    Ann Neurol. 2026 Jan 6. doi: 10.1002/ana.78115.
    PubMed     Abstract available


    December 2025
  3. PIAT C, Mullan AF, Ghoniem K, Turcano P, et al
    Autonomic Dysfunction and Risk of Mortality in Early-Onset Parkinson's Disease.
    Ann Neurol. 2025 Dec 31. doi: 10.1002/ana.78143.
    PubMed     Abstract available


  4. SIMEK M, Tykalova T, Novotny M, Illner V, et al
    Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease.
    Ann Neurol. 2025 Dec 30. doi: 10.1002/ana.78140.
    PubMed     Abstract available


  5. TALWAR P, Mortazavi N, Koshmanova E, Muto V, et al
    Age-Related Differences in the Association between REM Sleep and the Polygenic Risk for Parkinson's Disease.
    Ann Neurol. 2025 Dec 25. doi: 10.1002/ana.78112.
    PubMed     Abstract available


  6. ZHENG Y, Kou W, Yang G, Cai H, et al
    alpha-Synuclein Promotes the Expression and Release of Neurofilament Light Chain from Oligodendrocytes in a Murine Model: Implication for Multiple System Atrophy?
    Ann Neurol. 2025;98:1364-1379.
    PubMed     Abstract available


    October 2025
  7. JADAPALLI JK, Olson J, Irwin ZT, Nakhmani A, et al
    Sensorimotor Cortex High Frequency Oscillations Characterize Motor Symptom Severity during Deep Brain Stimulation Surgery for Parkinson's Disease.
    Ann Neurol. 2025 Oct 31. doi: 10.1002/ana.78077.
    PubMed     Abstract available


  8. LI Y, Tang F, Tang B, Qiu J, et al
    Reply to "Biallelic Variants in EPG5 Gene Are Associated With Parkinson's Disease".
    Ann Neurol. 2025 Oct 29. doi: 10.1002/ana.78080.
    PubMed    


  9. DAFSARI HS, Deneubourg C, Singh K, Maroofian R, et al
    Letter Concerning Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease.
    Ann Neurol. 2025 Oct 29. doi: 10.1002/ana.78081.
    PubMed    


  10. ELSHEHABI M, Hansen C, Hobert MA, von Thaler AK, et al
    Turning Slowly Predicts Future Diagnosis of Parkinson's Disease: A Decade-Long Longitudinal Analysis.
    Ann Neurol. 2025 Oct 21. doi: 10.1002/ana.78034.
    PubMed     Abstract available


  11. ZHU S, Jin W
    Reconsidering Central and Peripheral Contributions to Propranolol's Anti Tremor Effects in Parkinson's Disease.
    Ann Neurol. 2025 Oct 14. doi: 10.1002/ana.70019.
    PubMed    


  12. DAFSARI HS, Deneubourg C, Singh K, Maroofian R, et al
    Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism.
    Ann Neurol. 2025 Oct 6. doi: 10.1002/ana.78013.
    PubMed     Abstract available


  13. LOUIS ED, Hernandez NC, Guy T, Faust PL, et al
    The Relationship between Rest Tremor and Underlying Lewy Pathology in Essential Tremor: A Clinical-Pathological Study of 201 Cases.
    Ann Neurol. 2025;98:741-749.
    PubMed     Abstract available


    September 2025
  14. KIM J, Shulman JM
    Pleiotropy and the Increasing Complexity of Parkinson's Disease Genetics.
    Ann Neurol. 2025 Sep 13. doi: 10.1002/ana.78036.
    PubMed    


    August 2025
  15. DE NEELING MGJ, Keulen BJ, Stam MJ, Hubers D, et al
    Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing-Enabled Deep Brain Stimulation.
    Ann Neurol. 2025 Aug 29. doi: 10.1002/ana.78025.
    PubMed     Abstract available


  16. MULLER L, Ozduzenciler P, Schedlich-Teufer C, Seger A, et al
    Reply to "Urinary alpha-Synuclein for Parkinson's Detection: Key Limitations and Future Directions".
    Ann Neurol. 2025 Aug 11. doi: 10.1002/ana.70023.
    PubMed    


  17. MA J, Deng P, Liu S
    Urinary alpha-Synuclein for Parkinson's Detection: Key Limitations and Future Directions.
    Ann Neurol. 2025 Aug 11. doi: 10.1002/ana.70018.
    PubMed    


  18. VAN DER HEIDE A, Helmich RC
    Reply to "Reconsidering Central and Peripheral Contributions to Propranolol's Antitremor Effects in Parkinson's Disease".
    Ann Neurol. 2025 Aug 11. doi: 10.1002/ana.70016.
    PubMed    


  19. VAN DUIJVENBODEN S, Ramirez J, Scheurink J, Darweesh SKL, et al
    Heart Rate Profiles During Exercise and Incident Parkinson's Disease.
    Ann Neurol. 2025 Aug 2. doi: 10.1002/ana.70010.
    PubMed     Abstract available


    July 2025
  20. LIU M
    From Topography to Therapy: Rethinking Cognitive Monitoring in GBA1-Linked Parkinson's Disease.
    Ann Neurol. 2025 Jul 29. doi: 10.1002/ana.70007.
    PubMed    


  21. COLLOMB-CLERC A, Yeche M, Demain A, Van Hamme A, et al
    Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease.
    Ann Neurol. 2025 Jul 25. doi: 10.1002/ana.70003.
    PubMed     Abstract available


  22. ZHU S, Hong R, Wu Z, Bao Y, et al
    Sternocleidomastoid Muscle Overactivity: A Potentially Critical Contributor to Postural Abnormalities in Parkinson's Disease.
    Ann Neurol. 2025 Jul 16. doi: 10.1002/ana.27310.
    PubMed     Abstract available


    June 2025
  23. KANNARKAT GT, Zack R, Skrinak RT, Morley JF, et al
    Blood alpha-Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies.
    Ann Neurol. 2025 Jun 16. doi: 10.1002/ana.27288.
    PubMed     Abstract available


  24. MAFTEI D, Di Certo MG, Maurizi R, Veltri F, et al
    alpha-Synuclein-Related Mitochondria-Nrf2 Dysfunction in Parkinson's Disease Olfactory Mucosa.
    Ann Neurol. 2025 Jun 12. doi: 10.1002/ana.27292.
    PubMed     Abstract available


    April 2025
  25. MULLER L, Ozduzenciler P, Schedlich-Teufer C, Seger A, et al
    Elevated alpha-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease.
    Ann Neurol. 2025 Apr 26. doi: 10.1002/ana.27250.
    PubMed     Abstract available


  26. SLINGERLAND S, van der Zee S, Carli G, Slomp AC, et al
    Cholinergic Degeneration and Cognitive Function in Early GBA1-Related Parkinson's Disease.
    Ann Neurol. 2025 Apr 16. doi: 10.1002/ana.27248.
    PubMed     Abstract available


  27. SUN QY, Tang FL, Zhou Y, Pan HX, et al
    Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease.
    Ann Neurol. 2025 Apr 7. doi: 10.1002/ana.27242.
    PubMed     Abstract available


  28. BROWN EG, Chahine LM, Siderowf A, Gochanour C, et al
    Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease.
    Ann Neurol. 2025;97:730-740.
    PubMed     Abstract available


    March 2025
  29. DZIALAS V, Bischof GN, Mollenhoff K, Drzezga A, et al
    Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease.
    Ann Neurol. 2025 Mar 27. doi: 10.1002/ana.27223.
    PubMed     Abstract available


  30. SOMERVILLE EN, James A, Beetz C, Schwieger R, et al
    Plasma Glucosylceramide Levels Are Regulated by ATP10D and Are Not Involved in Parkinson's Disease Pathogenesis.
    Ann Neurol. 2025 Mar 1. doi: 10.1002/ana.27219.
    PubMed     Abstract available


    February 2025
  31. DAGAY A, Katzav S, Wasserman D, Gnoni V, et al
    Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease.
    Ann Neurol. 2025 Feb 21. doi: 10.1002/ana.27217.
    PubMed     Abstract available


  32. BACKMAN EA, Gardberg M, Luntamo L, Peurla M, et al
    Nigral Neuroinflammation and Dopaminergic Neurons in Parkinson's Disease and Atypical Parkinsonisms.
    Ann Neurol. 2025 Feb 7. doi: 10.1002/ana.27202.
    PubMed     Abstract available


    January 2025
  33. DI BIASE L, Pecoraro PM, Di Lazzaro V
    Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case-Control Study.
    Ann Neurol. 2025 Jan 27. doi: 10.1002/ana.27190.
    PubMed     Abstract available


  34. SNAPYAN M, Desmeules F, Munro J, Berard M, et al
    Adult Neurogenesis in the Subventricular Zone of Patients with Huntington's and Parkinson's Diseases and following Long-Term Treatment with Deep Brain Stimulation.
    Ann Neurol. 2025 Jan 19. doi: 10.1002/ana.27181.
    PubMed     Abstract available


  35. LI J, Chen D, Tang Y, Chen Z, et al
    Synaptic Density Reductions in MSA: A Potential Biomarker Identified Through [(18)F]SynVesT-1 PET Imaging.
    Ann Neurol. 2025 Jan 19. doi: 10.1002/ana.27179.
    PubMed     Abstract available


    December 2024
  36. VAN DER HEIDE A, Wessel M, Papadopetraki D, Geurts DEM, et al
    Propranolol Reduces Parkinson's Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial.
    Ann Neurol. 2024 Dec 21. doi: 10.1002/ana.27159.
    PubMed     Abstract available


  37. FLORES-TORRES MH, Hughes KC, Cortese M, Hung AY, et al
    Identifying Individuals in the Prodromal Phase of Parkinson's Disease: A Prospective Cohort Study.
    Ann Neurol. 2024 Dec 19. doi: 10.1002/ana.27166.
    PubMed     Abstract available


  38. DAIDA K, Yoshino H, Malik L, Baker B, et al
    The Utility of Long-Read Sequencing in Diagnosing Early Onset Parkinson's Disease.
    Ann Neurol. 2024 Dec 19. doi: 10.1002/ana.27155.
    PubMed     Abstract available


    October 2024
  39. CHERIF S, Tempier N, Yeche M, Temiz G, et al
    Directional Subthalamic Deep Brain Stimulation Better Improves Gait and Balance Disorders in Parkinson's Disease Patients: A Randomized Controlled Study.
    Ann Neurol. 2024 Oct 30. doi: 10.1002/ana.27099.
    PubMed     Abstract available


    September 2024
  40. BRUMBERG J, Blazhenets G, Buhler S, Fostitsch J, et al
    Cerebral Glucose Metabolism Is a Valuable Predictor of Survival in Patients with Lewy Body Diseases.
    Ann Neurol. 2024;96:539-550.
    PubMed     Abstract available


  41. CAMERUCCI E, Mullan AF, Turcano P, Stang CD, et al
    A Population-Based Approach to the Argument on Brain-First and Body-First Pathogenesis of Lewy Body Disease.
    Ann Neurol. 2024;96:551-559.
    PubMed     Abstract available


    August 2024
  42. PUIG-DAVI A, Martinez-Horta S, Perez-Carasol L, Horta-Barba A, et al
    Prediction of Cognitive Heterogeneity in Parkinson's Disease: A 4-Year Longitudinal Study Using Clinical, Neuroimaging, Biological and Electrophysiological Biomarkers.
    Ann Neurol. 2024 Aug 5. doi: 10.1002/ana.27035.
    PubMed     Abstract available


    May 2024
  43. ARENA G, Landoulsi Z, Grossmann D, Payne T, et al
    Polygenic Risk Scores Validated in Patient-Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease.
    Ann Neurol. 2024 May 20. doi: 10.1002/ana.26949.
    PubMed     Abstract available


  44. SAARINEN EK, Kuusimaki T, Lindholm K, Niemi K, et al
    Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease.
    Ann Neurol. 2024 May 20. doi: 10.1002/ana.26957.
    PubMed     Abstract available


  45. ZAMPOGNA A, Suppa A, Bove F, Cavallieri F, et al
    Disentangling Bradykinesia and Rigidity in Parkinson Disease: Evidence from Short- and Long-Term Subthalamic Nucleus Deep Brain Stimulation.
    Ann Neurol. 2024 May 9. doi: 10.1002/ana.26961.
    PubMed     Abstract available


  46. PRASUHN J, Schiefen T, Guber T, Henkel J, et al
    Levodopa Impairs the Energy Metabolism of the Basal Ganglia In Vivo.
    Ann Neurol. 2024;95:849-857.
    PubMed     Abstract available


    April 2024
  47. GONZALEZ-LATAPI P, Bustos B, Dong S, Lubbe S, et al
    Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease.
    Ann Neurol. 2024 Apr 2. doi: 10.1002/ana.26923.
    PubMed     Abstract available


  48. POST E, Hall DA, Bloem BR
    Reply to "An Apple a Day Will Not Keep the (Parkinson's Disease) Doctor at Bay!".
    Ann Neurol. 2024 Apr 1. doi: 10.1002/ana.26937.
    PubMed    


  49. KHANI M, Cerquera-Cleves C, Kekenadze M, Wild Crea P, et al
    Towards a Global View of Parkinson's Disease Genetics.
    Ann Neurol. 2024 Apr 1. doi: 10.1002/ana.26905.
    PubMed     Abstract available


  50. SAKOWSKI SA, Koubek EJ, Chen KS, Goutman SA, et al
    Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.
    Ann Neurol. 2024;95:635-652.
    PubMed     Abstract available


    March 2024
  51. BOOGERS A, Fasano A, Lang A
    An Apple a Day Will Not Keep the (Parkinson Disease) Doctor at Bay!
    Ann Neurol. 2024 Mar 30. doi: 10.1002/ana.26936.
    PubMed    


  52. KLUGE A, Borsche M, Streubel-Gallasch L, Gul T, et al
    alpha-Synuclein Pathology in PRKN-Linked Parkinson's Disease: New Insights from a Blood-Based Seed Amplification Assay.
    Ann Neurol. 2024 Mar 28. doi: 10.1002/ana.26917.
    PubMed     Abstract available


  53. DEL BENE VA, Martin RC, Brinkerhoff SA, Olson JW, et al
    Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.
    Ann Neurol. 2024 Mar 19. doi: 10.1002/ana.26903.
    PubMed     Abstract available


  54. ARNALDI D, Mattioli P, Raffa S, Pardini M, et al
    Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.
    Ann Neurol. 2024 Mar 11. doi: 10.1002/ana.26902.
    PubMed     Abstract available


    December 2023
  55. WIESMAN AI, da Silva Castanheira J, Fon EA, Baillet S, et al
    Alterations of cortical structure and neurophysiology in Parkinson's disease are aligned with neurochemical systems.
    Ann Neurol. 2023 Dec 26. doi: 10.1002/ana.26871.
    PubMed     Abstract available


  56. REYNOSO A, Torricelli R, Jacobs BM, Shi J, et al
    Gene-environment interactions for Parkinson's disease.
    Ann Neurol. 2023 Dec 19. doi: 10.1002/ana.26852.
    PubMed     Abstract available


    November 2023
  57. ZHOU L, Li SX, Chau SW, Huang B, et al
    Altered impulsivity across drug-naive parkinsonism, isolated REM sleep behavior disorder, and their high-risk relatives.
    Ann Neurol. 2023 Nov 23. doi: 10.1002/ana.26836.
    PubMed     Abstract available


  58. CHUN MY, Chung SJ, Kim SH, Park CW, et al
    Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson's Disease: An Early-Phase (18) F-FP-CIT PET Study.
    Ann Neurol. 2023 Nov 14. doi: 10.1002/ana.26827.
    PubMed     Abstract available


    August 2023
  59. MOHAMMADZADEH N, Tung GA, Prakash P, Alhusaini S, et al
    Parkinsonism: A Rare Complication of Cerebral Toxoplasmosis.
    Ann Neurol. 2023 Aug 30. doi: 10.1002/ana.26777.
    PubMed    


  60. KANG X, Ploner A, Roelstraete B, Ludvigsson JF, et al
    Risk of Parkinson's disease in celiac disease: A Swedish population-based study.
    Ann Neurol. 2023 Aug 26. doi: 10.1002/ana.26780.
    PubMed     Abstract available


    June 2023
  61. HE P, Shi L, Li Y, Duan Q, et al
    The Association of the Glymphatic Function with Parkinson's Disease Symptoms: Neuroimaging Evidence from Longitudinal and Cross-sectional Studies.
    Ann Neurol. 2023 Jun 28. doi: 10.1002/ana.26729.
    PubMed     Abstract available


  62. NIETHAMMER M, Tang CC, Jamora RDG, Vo A, et al
    A network imaging biomarker of X-linked dystonia-parkinsonism.
    Ann Neurol. 2023 Jun 27. doi: 10.1002/ana.26732.
    PubMed     Abstract available


  63. PALACIOS N, Wilkinson J, Bjornevik K, Schwarzschild MA, et al
    Metagenomics of the Gut Microbiome in Parkinson's Disease: Prodromal Changes.
    Ann Neurol. 2023 Jun 14. doi: 10.1002/ana.26719.
    PubMed     Abstract available


    May 2023
  64. HACKER ML, Rajamani N, Neudorfer C, Hollunder B, et al
    Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease.
    Ann Neurol. 2023 May 13. doi: 10.1002/ana.26674.
    PubMed     Abstract available


  65. WILKINS KB, Kehnemouyi YM, Petrucci MN, Anderson RW, et al
    Bradykinesia and Its Progression Are Related to Interhemispheric Beta Coherence.
    Ann Neurol. 2023;93:1029-1039.
    PubMed     Abstract available


    April 2023
  66. NEDELEC T, Couvy-Duchesne B, Darves-Bornoz A, Couronne R, et al
    A comparison between early presentation of dementia with Lewy Bodies, Alzheimer's disease and Parkinson's disease: evidence from routine primary care and UK Biobank data.
    Ann Neurol. 2023 Apr 25. doi: 10.1002/ana.26670.
    PubMed     Abstract available


    March 2023
  67. LIU B, Svenningsson P, Ludvigsson JF, Lundholm C, et al
    beta2-adrenoreceptor agonists, montelukast, and Parkinson's disease risk.
    Ann Neurol. 2023 Mar 10. doi: 10.1002/ana.26638.
    PubMed     Abstract available


  68. LANORE A, Casse F, Tesson C, Courtin T, et al
    Differences in survival across monogenic forms of Parkinson's disease.
    Ann Neurol. 2023 Mar 10. doi: 10.1002/ana.26636.
    PubMed     Abstract available


  69. TROPEA TF, Albuja I, Cousins KAQ, Irwin DJ, et al
    Concomitant Alzheimer's Disease Pathology in Parkinson's Disease Dementia.
    Ann Neurol. 2023 Mar 9. doi: 10.1002/ana.26635.
    PubMed    


  70. YOUNCE JR, Martin WRW, Perlmutter JS
    Reply to "Concomitant Alzheimer's Disease Pathology in Parkinson's Disease Dementia".
    Ann Neurol. 2023 Mar 9. doi: 10.1002/ana.26630.
    PubMed    


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