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Articles published in J Biol Chem

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    December 2020
  1. CLARK EH, Vazquez de la Torre A, Hoshikawa T, Briston T, et al
    Targeting mitophagy in Parkinson's disease.
    J Biol Chem. 2020 Dec 23:100209. doi: 10.1074/jbc.REV120.014294.
    PubMed     Abstract available


  2. CLARK EH, Vazquez de la Torre A, Hoshikawa T, Briston T, et al
    Targeting mitophagy in Parkinson's disease.
    J Biol Chem. 2020 Dec 18. pii: REV120.014294. doi: 10.1074/jbc.REV120.014294.
    PubMed     Abstract available


  3. GUINEY SJ, Adlard PA, Lei P, Mawal CH, et al
    Fibrillar alpha-synuclein toxicity depends on functional lysosomes.
    J Biol Chem. 2020;295:17497-17513.
    PubMed     Abstract available


    July 2020
  4. LAUTENSCHLAGER J, Wagner-Valladolid S, Stephens AD, Fernandez-Villegas A, et al
    Intramitochondrial proteostasis is directly coupled to alpha-synuclein and amyloid beta1-42 pathologies.
    J Biol Chem. 2020;295:10138-10152.
    PubMed     Abstract available


    May 2020
  5. LU J, Zhang S, Ma X, Jia C, et al
    Structural basis of the interplay between alpha-synuclein and Tau in regulating pathological amyloid aggregation.
    J Biol Chem. 2020;295:7470-7480.
    PubMed     Abstract available


    February 2020
  6. LEVY DR, Udgata A, Tourlomousis P, Symmons MF, et al
    Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
    J Biol Chem. 2020 Feb 28. pii: RA119.011842. doi: 10.1074/jbc.RA119.011842.
    PubMed     Abstract available


    January 2020
  7. KUMARI R, Kumar R, Kumar S, Singh AK, et al
    Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
    J Biol Chem. 2020 Jan 31. pii: RA119.009546. doi: 10.1074/jbc.RA119.009546.
    PubMed     Abstract available


  8. FROULA JM, Castellana-Cruz M, Anabtawi NM, Camino JD, et al
    Correction: Defining alpha-synuclein species responsible for Parkinson's disease phenotypes in mice.
    J Biol Chem. 2020;295:1142.
    PubMed    


    June 2019
  9. CHATTOPADHYAY M, Chowdhury AR, Feng T, Assenmacher CA, et al
    Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.
    J Biol Chem. 2019;294:10336-10348.
    PubMed     Abstract available


    May 2019
  10. FROULA JM, Castellana-Cruz M, Anabtawi NM, Camino JD, et al
    Defining alpha-synuclein species responsible for Parkinson disease phenotypes in mice.
    J Biol Chem. 2019 May 29. pii: RA119.007743. doi: 10.1074/jbc.RA119.007743.
    PubMed     Abstract available


  11. MCGLINCHEY RP, Lacy SM, Huffer KE, Tayebi N, et al
    C-terminal alpha-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
    J Biol Chem. 2019 May 15. pii: RA119.008930. doi: 10.1074/jbc.RA119.008930.
    PubMed     Abstract available


    April 2019
  12. PONZINI E, De Palma A, Cerboni L, Natalello A, et al
    Methionine oxidation in alpha-synuclein inhibits its propensity for ordered secondary structure.
    J Biol Chem. 2019;294:5657-5665.
    PubMed     Abstract available


    February 2019
  13. WU CX, Liao J, Park Y, Reed X, et al
    Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.
    J Biol Chem. 2019 Feb 22. pii: RA119.007631. doi: 10.1074/jbc.RA119.007631.
    PubMed     Abstract available


    November 2018
  14. YAMASAKI TR, Holmes BB, Furman JL, Dhavale DD, et al
    Parkinson's disease and multiple system atrophy have distinct alpha-synuclein seed characteristics.
    J Biol Chem. 2018 Nov 26. pii: RA118.004471. doi: 10.1074/jbc.RA118.004471.
    PubMed     Abstract available


    September 2018
  15. TERADA M, Suzuki G, Nonaka T, Kametani F, et al
    The effect of truncation on prion-like properties of alpha-synuclein.
    J Biol Chem. 2018;293:13910-13920.
    PubMed     Abstract available


    April 2018
  16. GIGUERE N, Pacelli C, Saumure C, Bourque MJ, et al
    Comparative analysis of Parkinson's disease-associated genes reveals altered survival and bioenergetics of parkin-deficient dopamine neurons in mice.
    J Biol Chem. 2018 Apr 26. pii: RA117.000499. doi: 10.1074/jbc.RA117.000499.
    PubMed     Abstract available


    March 2018
  17. AGUIRRE JD, Dunkerley KM, Lam R, Rusal M, et al
    Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.
    J Biol Chem. 2018 Mar 12. pii: RA117.000605. doi: 10.1074/jbc.RA117.000605.
    PubMed     Abstract available


    January 2018
  18. FLYNN JD, McGlinchey RP, Walker RL 3rd, Lee JC, et al
    Structural features of alpha-synuclein amyloid fibrils revealed by Raman spectroscopy.
    J Biol Chem. 2018;293:767-776.
    PubMed     Abstract available


    September 2017
  19. ASJAD HMM, Kasture A, El-Kasaby A, Sackel M, et al
    PHARMACOCHAPERONING IN A DROSOPHILA MODEL SYSTEM RESCUES HUMAN DOPAMINE TRANSPORTER VARIANTS ASSOCIATED WITH INFANTILE/JUVENILE PARKINSONISM.
    J Biol Chem. 2017 Sep 29. pii: jbc.M117.797092. doi: 10.1074/jbc.M117.797092.
    PubMed     Abstract available


  20. MORIARTY GM, Olson MP, Atieh TB, Janowska MK, et al
    A pH-dependent switch promotes beta-synuclein fibril formation via glutamate residues.
    J Biol Chem. 2017;292:16368-16379.
    PubMed     Abstract available


  21. LANDAU M
    Getting in charge of beta-synuclein fibrillation.
    J Biol Chem. 2017;292:16380-16381.
    PubMed     Abstract available


  22. HU ZY, Chen B, Zhang JP, Ma YY, et al
    Upregulation of autophagy-related gene 5 protects dopaminergic neurons in a zebrafish model of Parkinson's disease.
    J Biol Chem. 2017 Sep 19. pii: jbc.M116.764795. doi: 10.1074/jbc.M116.764795.
    PubMed     Abstract available


    August 2017
  23. AMIREDDY N, Puttapaka SN, Vinnakota RL, Ravuri HG, et al
    The Unintended Mitochondrial Uncoupling Effects of the FDA Approved Anti-Helminth Drug Nitazoxanide Mitigates Experimental Parkinsonism in Mice.
    J Biol Chem. 2017 Aug 10. pii: jbc.M117.791863. doi: 10.1074/jbc.M117.791863.
    PubMed     Abstract available


    June 2017
  24. DHAVALE DD, Tsai C, Bagchi DP, Engel LA, et al
    A sensitive assay reveals structural requirements for alpha-synuclein fibril growth.
    J Biol Chem. 2017;292:9034-9050.
    PubMed     Abstract available


    May 2017
  25. YOSHIMURA Y, Holmberg MA, Kukic P, Andersen CB, et al
    MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions.
    J Biol Chem. 2017;292:8269-8278.
    PubMed     Abstract available


    April 2017
  26. DE FRANCESCHI G, Fecchio C, Sharon R, Schapira AHV, et al
    alpha-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.
    J Biol Chem. 2017;292:6927-6937.
    PubMed     Abstract available


    November 2016
  27. PFAFF DH, Fleming T, Nawroth P, Teleman AA, et al
    Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification.
    J Biol Chem. 2016 Nov 30. pii: jbc.M116.743823.
    PubMed     Abstract available


    September 2016
  28. YANG X, Mudgett J, Bou-About G, Champy MF, et al
    Physiological Expression of AMPKgamma2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.
    J Biol Chem. 2016 Sep 12. pii: jbc.M116.738591.
    PubMed     Abstract available


    July 2016
  29. OIKAWA T, Nonaka T, Terada M, Tamaoka A, et al
    alpha-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.
    J Biol Chem. 2016;291:15046-56.
    PubMed     Abstract available


    June 2016
  30. KUMAR AS, Jagadeeshan S, Subramanian A, Chidambaram SB, et al
    Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.
    J Biol Chem. 2016;291:12310-21.
    PubMed     Abstract available


    May 2016
  31. LIU K, Li F, Han H, Chen Y, et al
    Parkin Regulates the Activity of Pyruvate Kinase M2.
    J Biol Chem. 2016;291:10307-17.
    PubMed     Abstract available


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