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Parkinson's Disease

Free Subscription Articles published in Proc Natl Acad Sci U S A Retrieve available abstracts of 61 articles: HTML format

Single Articles

April 2026
1. PONSI G, Villa R, Vico ID, Panasiti MS, et al
   Dopaminergic modulation of the sense of agency influences moral behavior in Parkinson's disease.
   Proc Natl Acad Sci U S A. 2026;123:e2513356123.
   PubMed     Abstract available
   
   
   
2. TOTH ZE, Barath M, Pape VFS, Sipos K, et al
   Lactoperoxidase is a candidate for mediating neuromelanin formation in the human substantia nigra.
   Proc Natl Acad Sci U S A. 2026;123:e2531597123.
   PubMed     Abstract available
   
   
   
3. MOON JS, Moutusy SI, Zhang M, Ndayisaba A, et al
   Cytotoxic T cell recognition of alpha-synuclein drives pathogenic immune responses in multiple system atrophy.
   Proc Natl Acad Sci U S A. 2026;123:e2537271123.
   PubMed     Abstract available
   
   
   March 2026
4. DING M, Chen B, Xiao J, Rong J, et al
   Endogenous ATP-powered nanomotors directing neural stem cell differentiation for Parkinson's disease treatment.
   Proc Natl Acad Sci U S A. 2026;123:e2520119123.
   PubMed     Abstract available
   
   
   
5. HASSANZADEH K, Liu J, Zhang J, Tabari MA, et al
   The cross-linking activity of transglutaminase 2 drives alpha-Synuclein pathology in synucleinopathy models.
   Proc Natl Acad Sci U S A. 2026;123:e2517886123.
   PubMed     Abstract available
   
   
   
6. ZOU Z, Zhou J, Lu Y, Huang Y, et al
   ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis.
   Proc Natl Acad Sci U S A. 2026;123:e2534066123.
   PubMed     Abstract available
   
   
   
7. LIM CM, Vendruscolo M
   The alpha-synuclein proteostasis network and its translational applications in Parkinson's disease.
   Proc Natl Acad Sci U S A. 2026;123:e2513317123.
   PubMed     Abstract available
   
   
   February 2026
8. 
   Correction Paschou et al., Dysregulated proteostasis in p.A53T-alpha-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.
   Proc Natl Acad Sci U S A. 2026;123:e2601834123.
   PubMed    
   
   
   
9. OLCHANYI MD, Schreier DR, Li J, Maffei C, et al
   Probabilistic mapping and automated segmentation of human brainstem white matter bundles.
   Proc Natl Acad Sci U S A. 2026;123:e2509321123.
   PubMed     Abstract available
   
   
   
10. WRIGHT S, Dang VC, Hussain S, Kandel P, et al
    Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4.
    Proc Natl Acad Sci U S A. 2026;123:e2515002123.
    PubMed     Abstract available
    
    
    January 2026
11. ZHU B, Liu Z, Van R, Wang H, et al
    Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models.
    Proc Natl Acad Sci U S A. 2026;123:e2513311123.
    PubMed     Abstract available
    
    
    
12. XU Y, Jin K, Chen J, Li Z, et al
    USP25 inhibition ameliorates Parkinson's disease by restoring mitophagy.
    Proc Natl Acad Sci U S A. 2026;123:e2516471123.
    PubMed     Abstract available
    
    
    November 2025
13. PASCHOU C, Apokotou O, Charmpi K, Kollias A, et al
    Dysregulated proteostasis in p.A53T-alpha-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.
    Proc Natl Acad Sci U S A. 2025;122:e2505240122.
    PubMed     Abstract available
    
    
    October 2025
14. MOHANTY B, Guo Z, Johnson LA, Wang J, et al
    Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement.
    Proc Natl Acad Sci U S A. 2025;122:e2510287122.
    PubMed     Abstract available
    
    
    
15. HAN M, Han Y, Jiang Z, Gao Y, et al
    Ultrasmall inorganic nanoparticles repair damaged meningeal lymphatic vessels to boost Parkinson's disease therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2503434122.
    PubMed     Abstract available
    
    
    September 2025
16. RODRIGUEZ JA, Minis A, Aref R, Nguyen HHM, et al
    PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism.
    Proc Natl Acad Sci U S A. 2025;122:e2511899122.
    PubMed     Abstract available
    
    
    August 2025
17. FERGUSON SM
    Derailed degradation: LRRK2-dependent exocytosis in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2515758122.
    PubMed    
    
    
    
18. NAIR SV, Jaimon E, Adhikari A, Nikoloff J, et al
    Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2504774122.
    PubMed     Abstract available
    
    
    July 2025
19. RONTGEN A, Toprakcioglu Z, Morris OM, Vendruscolo M, et al
    Amyloid-beta modulates the phase separation and aggregation of alpha-synuclein.
    Proc Natl Acad Sci U S A. 2025;122:e2501987122.
    PubMed     Abstract available
    
    
    
20. PALUMBOS SD, Popolow J, Goldsmith J, Holzbaur ELF, et al
    Autophagic stress activates distinct compensatory secretory pathways in neurons.
    Proc Natl Acad Sci U S A. 2025;122:e2421886122.
    PubMed     Abstract available
    
    
    May 2025
21. 
    Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2509530122.
    PubMed    
    
    
    April 2025
22. SONDERMANN P, Diercks CS, Rong C, Schultz PG, et al
    Targeted degradation of alpha-Synuclein using an evolved botulinum toxin protease.
    Proc Natl Acad Sci U S A. 2025;122:e2426745122.
    PubMed     Abstract available
    
    
    February 2025
23. BAGNOLI E, Lin YE, Burel S, Jaimon E, et al
    Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.
    Proc Natl Acad Sci U S A. 2025;122:e2412029122.
    PubMed     Abstract available
    
    
    November 2024
24. GILBOA T, Ter-Ovanesyan D, Wang SC, Whiteman S, et al
    Measurement of alpha-synuclein as protein cargo in plasma extracellular vesicles.
    Proc Natl Acad Sci U S A. 2024;121:e2408949121.
    PubMed     Abstract available
    
    
    October 2024
25. WILLIAMS D, Glasstetter LM, Jong TT, Chen T, et al
    High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2406009121.
    PubMed     Abstract available
    
    
    
26. COLEMAN CR, Pallos J, Arreola-Bustos A, Wang L, et al
    Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span.
    Proc Natl Acad Sci U S A. 2024;121:e2403450121.
    PubMed     Abstract available
    
    
    September 2024
27. WANG X, Geng J, Rimal S, Sui Y, et al
    The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1.
    Proc Natl Acad Sci U S A. 2024;121:e2400531121.
    PubMed     Abstract available
    
    
    
28. 
    Correction to Supporting Information for Woerman et al., Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
    Proc Natl Acad Sci U S A. 2024;121:e2417229121.
    PubMed    
    
    
    
29. URIBE-CANO S, Kottmann AH
    The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson's Disease.
    Proc Natl Acad Sci U S A. 2024;121:e2414226121.
    PubMed    
    
    
    
30. KIM Y, McInnes J, Kim J, Liang YHW, et al
    Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2406479121.
    PubMed     Abstract available
    
    
    
31. 
    Correction to Supporting Information for Chen et al., Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
    Proc Natl Acad Sci U S A. 2024;121:e2416001121.
    PubMed    
    
    
    August 2024
32. LIU K, Tao Y, Zhao Q, Xia W, et al
    Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
    Proc Natl Acad Sci U S A. 2024;121:e2321633121.
    PubMed     Abstract available
    
    
    
33. DEWISON KM, Rowlinson B, Machin JM, Crossley JA, et al
    Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways.
    Proc Natl Acad Sci U S A. 2024;121:e2315006121.
    PubMed     Abstract available
    
    
    
34. ROSENKRANTZ JL, Brandorff JE, Raghib S, Kapadia A, et al
    ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia-parkinsonism (XDP).
    Proc Natl Acad Sci U S A. 2024;121:e2401217121.
    PubMed     Abstract available
    
    
    
35. KHAN SS, Jaimon E, Lin YE, Nikoloff J, et al
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2402206121.
    PubMed     Abstract available
    
    
    
36. CONNELLY EM, Rintala-Dempsey AC, Gundogdu M, Freeman EA, et al
    Capturing the catalytic intermediates of parkin ubiquitination.
    Proc Natl Acad Sci U S A. 2024;121:e2403114121.
    PubMed     Abstract available
    
    
    July 2024
37. HOY CW, de Hemptinne C, Wang SS, Harmer CJ, et al
    Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.
    Proc Natl Acad Sci U S A. 2024;121:e2322869121.
    PubMed     Abstract available
    
    
    
38. GUPTA S, Tielemans A, Guevara CA, Huntley GW, et al
    Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.
    Proc Natl Acad Sci U S A. 2024;121:e2317833121.
    PubMed     Abstract available
    
    
    
39. 
    Correction for Ahuja et al., Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2411303121.
    PubMed    
    
    
    June 2024
40. 
    Correction for Prusiner et al., Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism.
    Proc Natl Acad Sci U S A. 2024;121:e2408899121.
    PubMed    
    
    
    May 2024
41. CAI W, Young CB, Yuan R, Lee B, et al
    Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2316149121.
    PubMed     Abstract available
    
    
    April 2024
42. MOHD RAFIQ N, Fujise K, Rosenfeld MS, Xu P, et al
    Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.
    Proc Natl Acad Sci U S A. 2024;121:e2318943121.
    PubMed     Abstract available
    
    
    February 2024
43. RILEY MJ, Mitchell CC, Ernst SE, Taylor EB, et al
    A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1.
    Proc Natl Acad Sci U S A. 2024;121:e2318956121.
    PubMed     Abstract available
    
    
    
44. RONTGEN A, Toprakcioglu Z, Tomkins JE, Vendruscolo M, et al
    Modulation of alpha-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
    Proc Natl Acad Sci U S A. 2024;121:e2313465121.
    PubMed     Abstract available
    
    
    January 2024
45. GILBOA T, Swank Z, Thakur R, Gould RA, et al
    Toward the quantification of alpha-synuclein aggregates with digital seed amplification assays.
    Proc Natl Acad Sci U S A. 2024;121:e2312031121.
    PubMed     Abstract available
    
    
    
46. AUBREY LD, Ninkina N, Ulamec SM, Abramycheva NY, et al
    Substitution of Met-38 to Ile in gamma-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
    Proc Natl Acad Sci U S A. 2024;121:e2309700120.
    PubMed     Abstract available
    
    
    
47. TONG Y, Zhang P, Yang X, Liu X, et al
    Decreasing the intrinsically disordered protein alpha-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
    Proc Natl Acad Sci U S A. 2024;121:e2306682120.
    PubMed     Abstract available
    
    
    
48. KAKUDA K, Ikenaka K, Kuma A, Doi J, et al
    Lysophagy protects against propagation of alpha-synuclein aggregation through ruptured lysosomal vesicles.
    Proc Natl Acad Sci U S A. 2024;121:e2312306120.
    PubMed     Abstract available
    
    
    December 2023
49. QI C, Verheijen BM, Kokubo Y, Shi Y, et al
    Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
    Proc Natl Acad Sci U S A. 2023;120:e2306767120.
    PubMed     Abstract available
    
    
    November 2023
50. BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al
    In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.
    Proc Natl Acad Sci U S A. 2023;120:e2311565120.
    PubMed     Abstract available
    
    
    October 2023
51. YESHAW WM, Adhikari A, Chiang CY, Dhekne HS, et al
    Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
    Proc Natl Acad Sci U S A. 2023;120:e2315171120.
    PubMed     Abstract available
    
    
    
52. LAI Y, Zhao C, Tian Z, Wang C, et al
    Neutral lysophosphatidylcholine mediates alpha-synuclein-induced synaptic vesicle clustering.
    Proc Natl Acad Sci U S A. 2023;120:e2310174120.
    PubMed     Abstract available
    
    
    
53. WANG X, Espadas J, Wu Y, Cai S, et al
    Membrane remodeling properties of the Parkinson's disease protein LRRK2.
    Proc Natl Acad Sci U S A. 2023;120:e2309698120.
    PubMed     Abstract available
    
    
    September 2023
54. KIM DY, Shin JY, Lee JE, Kim HN, et al
    A selective ER-phagy exerts neuroprotective effects via modulation of alpha-synuclein clearance in parkinsonian models.
    Proc Natl Acad Sci U S A. 2023;120:e2221929120.
    PubMed     Abstract available
    
    
    
55. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
    PubMed     Abstract available
    
    
    August 2023
56. YADAVALLI N, Ferguson SM
    LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition.
    Proc Natl Acad Sci U S A. 2023;120:e2303789120.
    PubMed     Abstract available
    
    
    July 2023
57. ZHANG S, Yi S, Wang L, Li S, et al
    Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia.
    Proc Natl Acad Sci U S A. 2023;120:e2301002120.
    PubMed     Abstract available
    
    
    June 2023
58. MATSUI H, Ito S, Matsui H, Ito J, et al
    Phosphorylation of alpha-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2214652120.
    PubMed     Abstract available
    
    
    April 2023
59. PENG JY, Qi ZX, Yan Q, Fan XJ, et al
    Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry.
    Proc Natl Acad Sci U S A. 2023;120:e2216247120.
    PubMed     Abstract available
    
    
    
60. SCHWARZ TC, Beier A, Ledolter K, Gossenreiter T, et al
    High-resolution structural information of membrane-bound alpha-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.
    Proc Natl Acad Sci U S A. 2023;120:e2201910120.
    PubMed     Abstract available
    
    
    March 2023
61. CHEUNG THC, Ding Y, Zhuang X, Kang UJ, et al
    Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment.
    Proc Natl Acad Sci U S A. 2023;120:e2213093120.
    PubMed     Abstract available
    
    

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