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Articles published in Proc Natl Acad Sci U S A

Retrieve available abstracts of 49 articles:
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Single Articles


    June 2022
  1. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
    PubMed     Abstract available


    May 2022
  2. ADAM EM, Brown EN, Kopell N, McCarthy MM, et al
    Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.
    Proc Natl Acad Sci U S A. 2022;119:e2120808119.
    PubMed     Abstract available


    April 2022
  3. STANDAERT DG, Childers GM
    Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204058119.
    PubMed    


  4. HINKLE JT, Patel J, Panicker N, Karuppagounder SS, et al
    STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha-synucleinopathy.
    Proc Natl Acad Sci U S A. 2022;119:e2118819119.
    PubMed     Abstract available


    March 2022
  5. AZEVEDO C, Teku G, Pomeshchik Y, Reyes JF, et al
    Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
    Proc Natl Acad Sci U S A. 2022;119:e2111405119.
    PubMed     Abstract available


  6. KIM J, Gao Y, Zhao Z, Rodrigues D, et al
    A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  7. SUN CP, Zhou JJ, Yu ZL, Huo XK, et al
    Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  8. SINGH RK, Soliman A, Guaitoli G, Stormer E, et al
    Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    February 2022
  9. AYERS JI, Lee J, Monteiro O, Woerman AL, et al
    Different alpha-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


  10. KILLINGER BA, Marshall LL, Chatterjee D, Chu Y, et al
    In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    January 2022
  11. HEREMANS IP, Caligiore F, Gerin I, Bury M, et al
    Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
    Proc Natl Acad Sci U S A. 2022;119.
    PubMed     Abstract available


    December 2021

  12. Correction to Supporting Information for Ahuja et al., Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed    


    November 2021
  13. AHUJA M, Ammal Kaidery N, Attucks OC, McDade E, et al
    Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    October 2021
  14. FOUGERE M, van der Zouwen CI, Boutin J, Neszvecsko K, et al
    Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  15. VOS M, Dulovic-Mahlow M, Mandik F, Frese L, et al
    Ceramide accumulation induces mitophagy and impairs beta-oxidation in PINK1 deficiency.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    September 2021
  16. SCHEIDT T, Carozza JA, Kolbe CC, Aprile FA, et al
    The binding of the small heat-shock protein alphaB-crystallin to fibrils of alpha-synuclein is driven by entropic forces.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  17. FRANCO A, Gracia P, Colom A, Camino JD, et al
    All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of alpha-synuclein toxic species.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    August 2021
  18. TOYAMA Y, Harkness RW, Kay LE
    Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    June 2021
  19. ZHANG S, Liu YQ, Jia C, Lim YJ, et al
    Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  20. TISZA MJ, Buck CB
    A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    May 2021
  21. LONG H, Zheng W, Liu Y, Sun Y, et al
    Wild-type alpha-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  22. YANG X, Wang B, Hoop CL, Williams JK, et al
    NMR unveils an N-terminal interaction interface on acetylated-alpha-synuclein monomers for recruitment to fibrils.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    April 2021
  23. TRUDLER D, Nazor KL, Eisele YS, Grabauskas T, et al
    Soluble alpha-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    March 2021
  24. SOBU Y, Wawro PS, Dhekne HS, Yeshaw WM, et al
    Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    January 2021
  25. REBELO D, Oliveira F, Abrunhosa A, Januario C, et al
    A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


  26. APICCO DJ, Shlevkov E, Nezich CL, Tran DT, et al
    The Parkinson's disease-associated gene ITPKB protects against alpha-synuclein aggregation by regulating ER-to-mitochondria calcium release.
    Proc Natl Acad Sci U S A. 2021;118.
    PubMed     Abstract available


    December 2020
  27. VRIJSEN S, Besora-Casals L, van Veen S, Zielich J, et al
    ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
    Proc Natl Acad Sci U S A. 2020;117:31198-31207.
    PubMed     Abstract available


    October 2020
  28. BREKK OR, Honey JR, Lee S, Hallett PJ, et al
    Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.
    Proc Natl Acad Sci U S A. 2020 Oct 15. pii: 2003021117.
    PubMed     Abstract available


  29. MOR DE, Sohrabi S, Kaletsky R, Keyes W, et al
    Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria.
    Proc Natl Acad Sci U S A. 2020 Oct 6. pii: 2009838117.
    PubMed     Abstract available


    September 2020
  30. AHN EH, Kang SS, Qi Q, Liu X, et al
    Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 14. pii: 2004087117.
    PubMed     Abstract available


    August 2020
  31. DEAN DN, Lee JC
    Defining an amyloid link Between Parkinson's disease and melanoma.
    Proc Natl Acad Sci U S A. 2020 Aug 31. pii: 2009702117.
    PubMed     Abstract available


    July 2020
  32. ZHAO K, Lim YJ, Liu Z, Long H, et al
    Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
    Proc Natl Acad Sci U S A. 2020 Jul 31. pii: 1922741117.
    PubMed     Abstract available


  33. MIZRAHI-KLIGER AD, Kaplan A, Israel Z, Deffains M, et al
    Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia.
    Proc Natl Acad Sci U S A. 2020 Jul 7. pii: 2001560117.
    PubMed     Abstract available


  34. NGUYEN APT, Tsika E, Kelly K, Levine N, et al
    Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
    Proc Natl Acad Sci U S A. 2020 Jul 6. pii: 1922184117.
    PubMed     Abstract available


    June 2020
  35. HANNESTAD JK, Rocha S, Agnarsson B, Zhdanov VP, et al
    Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric alpha-synuclein.
    Proc Natl Acad Sci U S A. 2020;117:14178-14186.
    PubMed     Abstract available


    May 2020
  36. ZHANG Q, Xu Y, Lee J, Jarnik M, et al
    A myosin-7B-dependent endocytosis pathway mediates cellular entry of alpha-synuclein fibrils and polycation-bearing cargos.
    Proc Natl Acad Sci U S A. 2020;117:10865-10875.
    PubMed     Abstract available


  37. CAO M, Park D, Wu Y, De Camilli P, et al
    Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1.
    Proc Natl Acad Sci U S A. 2020 May 18. pii: 2004335117.
    PubMed     Abstract available


  38. FAVA VM, Cobat A, Gzara C, Alcais A, et al
    Reply to Zhang et al.: The differential role of LRRK2 variants in nested leprosy phenotypes.
    Proc Natl Acad Sci U S A. 2020;117:10124-10125.
    PubMed    


    April 2020
  39. ZHANG DF, Wang D, Li YY, Yao YG, et al
    Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?
    Proc Natl Acad Sci U S A. 2020 Apr 28. pii: 2000533117.
    PubMed    


  40. LUAN Y, Tang D, Wu H, Gu W, et al
    Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice.
    Proc Natl Acad Sci U S A. 2020 Apr 20. pii: 1916263117.
    PubMed     Abstract available


    March 2020

  41. Correction for Cristopher Bragg et al., Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1.
    Proc Natl Acad Sci U S A. 2020 Mar 9. pii: 2003190117.
    PubMed    


  42. MAHUL-MELLIER AL, Burtscher J, Maharjan N, Weerens L, et al
    The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is one of the major drivers of neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:4971-4982.
    PubMed     Abstract available


    February 2020
  43. HAM SJ, Lee D, Yoo H, Jun K, et al
    Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
    Proc Natl Acad Sci U S A. 2020;117:4281-4291.
    PubMed     Abstract available


  44. BOYER DR, Li B, Sun C, Fan W, et al
    The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
    Proc Natl Acad Sci U S A. 2020;117:3592-3602.
    PubMed     Abstract available


    January 2020
  45. EARLS RH, Menees KB, Chung J, Gutekunst CA, et al
    NK cells clear alpha-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of alpha-synucleinopathy.
    Proc Natl Acad Sci U S A. 2020;117:1762-1771.
    PubMed     Abstract available


    December 2019
  46. VITEK JL, Johnson LA
    Understanding Parkinson's disease and deep brain stimulation: Role of monkey models.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1902300116.
    PubMed     Abstract available


    November 2019
  47. AGGARWAL A, Reichert H, VijayRaghavan K
    A locomotor assay reveals deficits in heterozygous Parkinson's disease model and proprioceptive mutants in adult Drosophila.
    Proc Natl Acad Sci U S A. 2019 Nov 20. pii: 1807456116.
    PubMed     Abstract available


  48. CHOPEK JW, Hultborn H, Brownstone RM
    Multistable properties of human subthalamic nucleus neurons in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 1912128116.
    PubMed     Abstract available


    September 2019
  49. MORI A, Hatano T, Inoshita T, Shiba-Fukushima K, et al
    Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and alpha-synuclein stability through membrane remodeling.
    Proc Natl Acad Sci U S A. 2019 Sep 23. pii: 1902958116.
    PubMed     Abstract available


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