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Articles published in Toxicol Sci

Retrieve available abstracts of 39 articles:
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Single Articles

    March 2024
  1. AKAKPO JY, Olivos H, Shrestha B, Midey A, et al
    Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging.
    Toxicol Sci. 2024;198:328-346.
    PubMed     Abstract available

    February 2024
  2. TAKIMOTO N, Ishii Y, Mitsumoto T, Takasu S, et al
    Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
    Toxicol Sci. 2024;198:40-49.
    PubMed     Abstract available

  3. XU C, Yan F, Zhao Y, Jaeschke H, et al
    Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARgamma and autophagy.
    Toxicol Sci. 2024;198:50-60.
    PubMed     Abstract available

  4. O'SHAUGHNESSY KL, Sasser AL, Bell KS, Riutta C, et al
    Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.
    Toxicol Sci. 2024;198:128-140.
    PubMed     Abstract available

  5. WIJAYA LS, Gabor A, Pot IE, van de Have L, et al
    A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury.
    Toxicol Sci. 2024;198:14-30.
    PubMed     Abstract available

    December 2023
  6. GHOSH P, Magee N, Akakpo JY, Ahamed F, et al
    Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2.
    Toxicol Sci. 2023;197:53-68.
    PubMed     Abstract available

  7. OGESE MO, Lister A, Farrell L, Gardner J, et al
    A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment.
    Toxicol Sci. 2023;197:38-52.
    PubMed     Abstract available

    October 2023
  8. RUSSOMANNO G, Sison-Young R, Livoti LA, Coghlan H, et al
    A systems approach reveals species differences in hepatic stress response capacity.
    Toxicol Sci. 2023;196:112-125.
    PubMed     Abstract available

    September 2023
  9. FERGANY A, Zong C, Ekuban FA, Suzuki A, et al
    Deletion of IL-1beta exacerbates acrylamide-induced neurotoxicity in mice.
    Toxicol Sci. 2023;195:246-256.
    PubMed     Abstract available

    July 2023
  10. ZHUO X, Howell BA, Shen H, Woodhead JL, et al
    Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
    Toxicol Sci. 2023;194:235-245.
    PubMed     Abstract available

    March 2023
  11. ALI SE, Waddington JC, Lister A, Sison-Young R, et al
    Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
    Toxicol Sci. 2023;192:106-116.
    PubMed     Abstract available

  12. MAASS C, Schaller S, Dallmann A, Bothe K, et al
    Considering developmental neurotoxicity in vitro data for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study.
    Toxicol Sci. 2023;192:59-70.
    PubMed     Abstract available

    February 2023
  13. AMAR SK, Donohue KB, Gust KA
    Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts.
    Toxicol Sci. 2023;191:285-295.
    PubMed     Abstract available

    November 2022
  14. BEBARTA VS, Shi X, Zheng S, Hendry-Hofer TB, et al
    Intramuscular Administration of Glyoxylate Rescues Swine from Lethal Cyanide Poisoning and Ameliorates the Biochemical Sequalae of Cyanide Intoxication.
    Toxicol Sci. 2022 Nov 3. pii: 6795012. doi: 10.1093.
    PubMed     Abstract available

    October 2022
  15. JIANG Y, Zhou Y, Song S, Fan S, et al
    St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation.
    Toxicol Sci. 2022;190:54-63.
    PubMed     Abstract available

    August 2022
  16. CHEN Y, Song W, Ge W, Yan R, et al
    Metabolic competency of larval zebrafish in drug-induced liver injury: a case study of acetaminophen poisoning.
    Toxicol Sci. 2022 Aug 9. pii: 6659117. doi: 10.1093.
    PubMed     Abstract available

    July 2022
  17. NGUYEN NT, Umbaugh DS, Huang EL, Adelusi OB, et al
    Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
    Toxicol Sci. 2022;188:248-260.
    PubMed     Abstract available

  18. MARTIN MT, Koza-Taylor P, Di L, Watt ED, et al
    Early Drug-Induced Liver Injury Risk Screening: "Free," as Good as It Gets.
    Toxicol Sci. 2022;188:208-218.
    PubMed     Abstract available

    June 2022
  19. WOODHEAD JL, Siler SQ, Howell BA, Watkins PB, et al
    Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.
    Toxicol Sci. 2022;188:108-116.
    PubMed     Abstract available

    April 2022
  20. CARSTENS KE, Carpenter AF, Martin MM, Harrill JA, et al
    Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity.
    Toxicol Sci. 2022;187:62-79.
    PubMed     Abstract available

    February 2022
  21. MARABLE CA, Frank CL, Seim RF, Hester S, et al
    Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated With Chemical Alterations of In Vitro Neural Network Formation.
    Toxicol Sci. 2022;186:118-133.
    PubMed     Abstract available

    January 2022
  22. MORRIS J, Bealer EJ, Souza IDS, Repmann L, et al
    Chemical Exposure-Induced Developmental Neurotoxicity in Head-Regenerating Schmidtea mediterranea.
    Toxicol Sci. 2022;185:220-231.
    PubMed     Abstract available

  23. SHERLOCK LG, Balasubramaniyan D, Zheng L, Grayck M, et al
    APAP-Induced IkappaBbeta/NFkappaB Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation.
    Toxicol Sci. 2022;185:158-169.
    PubMed     Abstract available

    December 2021
  24. CHEN S, Tang Y, Fang W, He T, et al
    CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury.
    Toxicol Sci. 2021;185:19-27.
    PubMed     Abstract available

    November 2021
  25. POUDEL S, Cabrera DP, Bhushan B, Manley MW, et al
    Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury.
    Toxicol Sci. 2021;184:276-285.
    PubMed     Abstract available

    September 2021
  26. ANDERSON FL, von Herrmann KM, Young AL, Havrda MC, et al
    Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos.
    Toxicol Sci. 2021;183:378-392.
    PubMed     Abstract available

    August 2021
  27. HUTIN D, Long AS, Sugamori K, Shao P, et al
    2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality.
    Toxicol Sci. 2021;183:154-169.
    PubMed     Abstract available

  28. KRALJ T, Brouwer KLR, Creek DJ
    Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury.
    Toxicol Sci. 2021;183:1-13.
    PubMed     Abstract available

    May 2021
  29. BELAIR DG, Sudak K, Connelly K, Collins ND, et al
    Investigation Into the Role of ERK in Tyrosine Kinase Inhibitor-Induced Neuropathy.
    Toxicol Sci. 2021;181:160-174.
    PubMed     Abstract available

  30. YAN T, Yan N, Wang H, Yagai T, et al
    FXR-Deoxycholic Acid-TNF-alpha Axis Modulates Acetaminophen-Induced Hepatotoxicity.
    Toxicol Sci. 2021;181:273-284.
    PubMed     Abstract available

  31. UMBAUGH DS, Ramachandran A, Jaeschke H
    Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape after an Acetaminophen Overdose using Single-cell RNA Sequencing.
    Toxicol Sci. 2021 May 12. pii: 6275242. doi: 10.1093.
    PubMed     Abstract available

    April 2021
  32. SHEHU AI, Zhu J, Li J, Lu J, et al
    Targeting Xenobiotic Nuclear Receptors PXR and CAR to Prevent Cobicistat Hepatotoxicity.
    Toxicol Sci. 2021;181:58-67.
    PubMed     Abstract available

  33. LLEWELLYN HP, Vaidya VS, Wang Z, Peng Q, et al
    Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans.
    Toxicol Sci. 2021;181:23-34.
    PubMed     Abstract available

    February 2021
  34. UMBAUGH DS, Nguyen NT, Jaeschke H, Ramachandran A, et al
    Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure.
    Toxicol Sci. 2021;180:186-195.
    PubMed     Abstract available

    January 2021
  35. LI D, Knox B, Gong B, Chen S, et al
    Identification of Translational microRNA Biomarker Candidates for Ketoconazole-Induced Liver Injury Using Next-Generation Sequencing.
    Toxicol Sci. 2021;179:31-43.
    PubMed     Abstract available

  36. HAMMOND S, Gibson A, Jaruthamsophon K, Roth S, et al
    Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite.
    Toxicol Sci. 2021;179:95-107.
    PubMed     Abstract available

    February 2020
  37. KOHARA H, Bajaj P, Yamanaka K, Miyawaki A, et al
    High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice.
    Toxicol Sci. 2020;173:347-361.
    PubMed     Abstract available

  38. VAZQUEZ JH, Clemens MM, Allard FD, Yee EU, et al
    Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
    Toxicol Sci. 2020;173:244-254.
    PubMed     Abstract available

  39. LOPEZ-RIERA M, Conde I, Castell JV, Jover R, et al
    A Novel MicroRNA Signature for Cholestatic Drugs in Human Hepatocytes and Its Translation into Novel Circulating Biomarkers for Drug-Induced Liver Injury Patients.
    Toxicol Sci. 2020;173:229-243.
    PubMed     Abstract available

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