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Articles published in Toxicol Sci

Retrieve available abstracts of 49 articles:
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Single Articles


    February 2020
  1. KOHARA H, Bajaj P, Yamanaka K, Miyawaki A, et al
    High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice.
    Toxicol Sci. 2020;173:347-361.
    PubMed     Abstract available


  2. VAZQUEZ JH, Clemens MM, Allard FD, Yee EU, et al
    Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
    Toxicol Sci. 2020;173:244-254.
    PubMed     Abstract available


  3. LOPEZ-RIERA M, Conde I, Castell JV, Jover R, et al
    A Novel MicroRNA Signature for Cholestatic Drugs in Human Hepatocytes and Its Translation into Novel Circulating Biomarkers for Drug-Induced Liver Injury Patients.
    Toxicol Sci. 2020;173:229-243.
    PubMed     Abstract available


    June 2019
  4. PINA B, Ziv T, Faria M, Ben-Lulu S, et al
    Multi-omic analysis of zebrafish models of acute organophosphorus poisoning with different severity.
    Toxicol Sci. 2019 Jun 19. pii: 5520468. doi: 10.1093.
    PubMed     Abstract available


    April 2019
  5. CHAO MW, Kuo HC, Tong SY, Yang YS, et al
    In Vitro and In Vivo Analysis of the Effects of 3,5-DMA and Its Metabolites in Neural Oxidative Stress and Neurodevelopmental Toxicity.
    Toxicol Sci. 2019;168:405-419.
    PubMed     Abstract available


  6. HAOUZI P, Tubbs N, Cheung J, Judenherc-Haouzi A, et al
    Methylene Blue Administration During and After Life-Threatening Intoxication by Hydrogen Sulfide: Efficacy Studies in Adult Sheep and Mechanisms of Action.
    Toxicol Sci. 2019;168:443-459.
    PubMed     Abstract available


    March 2019
  7. QUEVEDO C, Behl M, Ryan K, Paules RS, et al
    Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish.
    Toxicol Sci. 2019;168:225-240.
    PubMed     Abstract available


  8. WANG X, Han L, Bi Y, Li C, et al
    Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice.
    Toxicol Sci. 2019;168:264-278.
    PubMed     Abstract available


  9. BAILEY WJ, Barnum JE, Erdos Z, LaFranco-Scheuch L, et al
    A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury.
    Toxicol Sci. 2019;168:110-125.
    PubMed     Abstract available


    February 2019
  10. LONGO DM, Woodhead JL, Walker P, Heredi-Szabo K, et al
    Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
    Toxicol Sci. 2019;167:458-467.
    PubMed     Abstract available


  11. GIUSTARINI G, Vrisekoop N, Kruijssen L, Wagenaar L, et al
    Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.
    Toxicol Sci. 2019;167:385-396.
    PubMed     Abstract available


  12. SUO J, Zhang C, Wang P, Hou L, et al
    Allyl Sulfide Counteracts 1-Bromopropane-Induced Neurotoxicity by Inhibiting Neuroinflammation and Oxidative Stress.
    Toxicol Sci. 2019;167:397-407.
    PubMed     Abstract available


    January 2019
  13. BEHL M, Ryan K, Hsieh JH, Parham F, et al
    Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here.
    Toxicol Sci. 2019;167:6-14.
    PubMed     Abstract available


  14. SACHANA M, Bal-Price A, Crofton KM, Bennekou SH, et al
    International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing.
    Toxicol Sci. 2019;167:45-57.
    PubMed     Abstract available


  15. TAGUCHI K, Masui S, Itoh T, Miyajima A, et al
    Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor.
    Toxicol Sci. 2019;167:227-238.
    PubMed     Abstract available


  16. NIHIRA K, Nan-Ya KI, Kakuni M, Ono Y, et al
    Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5.
    Toxicol Sci. 2019;167:190-201.
    PubMed     Abstract available


  17. SIRENKO O, Parham F, Dea S, Sodhi N, et al
    Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures.
    Toxicol Sci. 2019;167:58-76.
    PubMed     Abstract available


  18. HAGSTROM D, Truong L, Zhang S, Tanguay R, et al
    Comparative Analysis of Zebrafish and Planarian Model Systems for Developmental Neurotoxicity Screens Using an 87-Compound Library.
    Toxicol Sci. 2019;167:15-25.
    PubMed     Abstract available


    June 2018
  19. LINDEBLAD M, Lyubimov A, van Breemen R, Gierszal K, et al
    The bile sequestrant cholestyramine increases survival in a rabbit model of brodifacoum poisoning.
    Toxicol Sci. 2018 Jun 12. pii: 5036169. doi: 10.1093.
    PubMed     Abstract available


    April 2018
  20. BELL CC, Dankers ACA, Lauschke VM, Sison-Young R, et al
    Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
    Toxicol Sci. 2018;162:655-666.
    PubMed     Abstract available


  21. MCGREAL SR, Bhushan B, Walesky C, McGill MR, et al
    Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.
    Toxicol Sci. 2018;162:599-610.
    PubMed     Abstract available


  22. SONG B, Aoki S, Liu C, Susukida T, et al
    An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury.
    Toxicol Sci. 2018;162:713-723.
    PubMed     Abstract available


  23. WU Y, Xu Y, Huang X, Ye D, et al
    Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity.
    Toxicol Sci. 2018;162:688-701.
    PubMed     Abstract available


  24. LIANG LP, Pearson-Smith JN, Huang J, McElroy P, et al
    Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model.
    Toxicol Sci. 2018;162:611-621.
    PubMed     Abstract available


  25. CHAN R, Benet LZ
    Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI.
    Toxicol Sci. 2018;162:499-508.
    PubMed     Abstract available


    March 2018
  26. WEI M, Zheng Z, Shi L, Jin Y, et al
    Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
    Toxicol Sci. 2018;162:99-112.
    PubMed     Abstract available


  27. SHAH F, Medvedev A, Wassermann AM, Brodney M, et al
    The Identification of Pivotal Transcriptional Factors Mediating Cell Responses to Drugs With Drug-Induced Liver Injury Liabilities.
    Toxicol Sci. 2018;162:177-188.
    PubMed     Abstract available


    February 2018
  28. MAK A, Kato R, Weston K, Hayes A, et al
    Editor's Highlight: An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI.
    Toxicol Sci. 2018;161:412-420.
    PubMed     Abstract available


    January 2018
  29. ZHANG XL, McGlothan JL, Miry O, Stansfield KH, et al
    From the Cover: 7,8-Dihydroxyflavone Rescues Lead-Induced Impairment of Vesicular Release: A Novel Therapeutic Approach for Lead Intoxicated Children.
    Toxicol Sci. 2018;161:186-195.
    PubMed     Abstract available


    June 2017
  30. WU X, Yang X, Majumder A, Swetenburg R, et al
    From the Cover: AstrocytesAre Protective Against Chlorpyrifos Developmental Neurotoxicity in Human Pluripotent Stem Cell-Derived Astrocyte-Neuron Cocultures.
    Toxicol Sci. 2017;157:410-420.
    PubMed     Abstract available


  31. WARE BR, McVay M, Sunada WY, Khetani SR, et al
    Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling.
    Toxicol Sci. 2017;157:387-398.
    PubMed     Abstract available


  32. YUCHA RW, He K, Shi Q, Cai L, et al
    In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties.
    Toxicol Sci. 2017;157:487-499.
    PubMed     Abstract available


  33. SISO S, Hobson BA, Harvey DJ, Bruun DA, et al
    Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.
    Toxicol Sci. 2017;157:330-341.
    PubMed     Abstract available


  34. HOBSON BA, Siso S, Rowland DJ, Harvey DJ, et al
    From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.
    Toxicol Sci. 2017;157:342-353.
    PubMed     Abstract available


    April 2017
  35. MOSEDALE M, Kim Y, Brock WJ, Roth SE, et al
    Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.
    Toxicol Sci. 2017;156:438-454.
    PubMed     Abstract available


  36. RAY JL, Kopec AK, Joshi N, Cline-Fedewa H, et al
    Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis.
    Toxicol Sci. 2017;156:428-437.
    PubMed     Abstract available


  37. OGURA K, Terasaki Y, Miyoshi-Akiyama T, Terasaki M, et al
    Vibrio cholerae Cholix Toxin-Induced HepG2 Cell Death is Enhanced by Tumor Necrosis Factor-Alpha Through ROS and Intracellular Signal-Regulated Kinases.
    Toxicol Sci. 2017;156:455-468.
    PubMed     Abstract available


    March 2017
  38. GUO L, Hamre J 3rd, Eldridge S, Behrsing HP, et al
    Editor's Highlight: Multiparametric Image Analysis of Rat Dorsal Root Ganglion Cultures to Evaluate Peripheral Neuropathy-Inducing Chemotherapeutics.
    Toxicol Sci. 2017;156:275-288.
    PubMed     Abstract available


  39. BOADAS-VAELLO P, Sedo-Cabezon L, Verdu E, Llorens J, et al
    Strain and Sex Differences in the Vestibular and Systemic Toxicity of 3,3'-Iminodipropionitrile in Mice.
    Toxicol Sci. 2017;156:109-122.
    PubMed     Abstract available


  40. NEMMICHE S
    Oxidative Signaling Response to Cadmium Exposure.
    Toxicol Sci. 2017;156:4-10.
    PubMed     Abstract available


    February 2017
  41. BHUSHAN B, Chavan H, Borude P, Xie Y, et al
    Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
    Toxicol Sci. 2017;155:363-378.
    PubMed     Abstract available


    October 2016
  42. JEITNER TM, Kalogiannis M, Krasnikov BF, Gomolin I, et al
    Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons.
    Toxicol Sci. 2016;153:410.
    PubMed    


    April 2016
  43. LI Y, Wang L, Ju L, Deng H, et al
    A Systematic Strategy for Screening and Application of Specific Biomarkers in Hepatotoxicity Using Metabolomics Combined With ROC Curves and SVMs.
    Toxicol Sci. 2016;150:390-9.
    PubMed     Abstract available


    March 2016
  44. HU J, Ramshesh VK, McGill MR, Jaeschke H, et al
    Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
    Toxicol Sci. 2016;150:204-15.
    PubMed     Abstract available


  45. CHURCH RJ, Otieno M, McDuffie JE, Singh B, et al
    Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats.
    Toxicol Sci. 2016;150:3-14.
    PubMed     Abstract available


    February 2016
  46. WAHLBERG K, Kippler M, Alhamdow A, Rahman SM, et al
    Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function.
    Toxicol Sci. 2016;149:473-83.
    PubMed     Abstract available


  47. MAIURI AR, Breier AB, Turkus JD, Ganey PE, et al
    Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines.
    Toxicol Sci. 2016;149:372-84.
    PubMed     Abstract available


    January 2016
  48. SLIZGI JR, Lu Y, Brouwer KR, St Claire RL, et al
    Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?
    Toxicol Sci. 2016;149:237-50.
    PubMed     Abstract available


  49. KLEIN S, Maggioni S, Bucher J, Mueller D, et al
    In Silico Modeling for the Prediction of Dose and Pathway-Related Adverse Effects in Humans From In Vitro Repeated-Dose Studies.
    Toxicol Sci. 2016;149:55-66.
    PubMed     Abstract available


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