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Articles published in Am J Respir Crit Care Med

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Single Articles


    April 2018
  1. SEYMOUR CW, Bernard G
    Making Sepsis Molecular - Is There Enough Time for New Tests?
    Am J Respir Crit Care Med. 2018 Apr 20. doi: 10.1164/rccm.201804-0684.
    PubMed     Text format    


  2. CRAWFORD K, DeWitt A, Brierre S, Caffery T, et al
    Rapid Biophysical Analysis of Host Immune Cell Variations Associated with Sepsis.
    Am J Respir Crit Care Med. 2018 Apr 9. doi: 10.1164/rccm.201710-2077.
    PubMed     Text format    


  3. MILLER III RR, Lopansri BK, Burke JP, Levy M, et al
    Validation of a Host Response Assay, Septicyte LAB, for Discriminating Sepsis from SIRS in the ICU.
    Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201712-2472.
    PubMed     Text format     Abstract available


    March 2018
  4. TORRES LK, Choi AMK
    Determination of Early Immune Function in Sepsis and Its Influence on Organ Dysfunction - Is a More Pragmatic Outcome on the Horizon?
    Am J Respir Crit Care Med. 2018 Mar 20. doi: 10.1164/rccm.201803-0470.
    PubMed     Text format    


  5. MASSON-ROY S, Saito H, Pittet D
    The WHO 2018 Hand Hygiene Campaign: Make a Difference, Prevent Sepsis in Health Care.
    Am J Respir Crit Care Med. 2018 Mar 6. doi: 10.1164/rccm.201802-0362.
    PubMed     Text format    


    February 2018
  6. LAMEIRE N, Vanmassenhove J
    Timing of Dialysis in Sepsis and Acute Respiratory Distress Syndrome.
    Am J Respir Crit Care Med. 2018 Feb 2. doi: 10.1164/rccm.201801-0129.
    PubMed     Text format    


    January 2018
  7. MAZERAUD A PHD, Bozza FA MD, PhD, Sharshar T
    The Sepsis-associated Encephalopathy is Septic.
    Am J Respir Crit Care Med. 2018 Jan 23. doi: 10.1164/rccm.201712-2593.
    PubMed     Text format    


    December 2017
  8. SINGER BH, Dickson RP, Denstaedt SJ, Newstead MW, et al
    Bacterial Dissemination to the Brain in Sepsis.
    Am J Respir Crit Care Med. 2017 Dec 12. doi: 10.1164/rccm.201708-1559.
    PubMed     Text format     Abstract available



  9. What Is Sepsis?
    Am J Respir Crit Care Med. 2017;196:P21-P22.
    PubMed     Text format    


    November 2017
  10. SAPEY E, Patel JM, Greenwood HL, Walton GM, et al
    Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.
    Am J Respir Crit Care Med. 2017;196:1325-1336.
    PubMed     Text format     Abstract available


    October 2017
  11. GOTTS JE, Matthay MA
    Cell-based Therapy in Sepsis: A Step Closer.
    Am J Respir Crit Care Med. 2017 Oct 26. doi: 10.1164/rccm.201710-2068.
    PubMed     Text format    


  12. PATEL JJ, Rosenthal MD, McClave SA, Martindale RG, et al
    Tempering the Clinical Effects of Early Myeloid Derived Suppressor Cell Expansion in Severe Sepsis and Septic Shock.
    Am J Respir Crit Care Med. 2017 Oct 6. doi: 10.1164/rccm.201708-1701.
    PubMed     Text format    


  13. UHEL F, Camus C, Gacouin A, Tadie JM, et al
    Reply to: Tempering the Clinical Effects of Early Myeloid Derived Suppressor Cell Expansion in Severe Sepsis and Septic Shock.
    Am J Respir Crit Care Med. 2017 Oct 6. doi: 10.1164/rccm.201709-1854.
    PubMed     Text format    


  14. SCICLUNA BP, Wiewel MA, van Vught LA, Hoogendijk AJ, et al
    A Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis Upon Intensive Care Unit Admission.
    Am J Respir Crit Care Med. 2017 Oct 3. doi: 10.1164/rccm.201707-1339.
    PubMed     Text format    


    September 2017
  15. SHEA BS, Opal SM
    The Role of S1PR3 in Protection from Bacterial Sepsis.
    Am J Respir Crit Care Med. 2017 Sep 14. doi: 10.1164/rccm.201708-1726.
    PubMed     Text format    


  16. RANZANI OT, Torres A
    Reply to: Sepsis-3 in Community-acquired Pneumonia: How Reliable is It?
    Am J Respir Crit Care Med. 2017 Sep 11. doi: 10.1164/rccm.201708-1598.
    PubMed     Text format    


  17. AKINOSOGLOU K, Gogos C
    Sepsis-3 in Community-acquired Pneumonia: How Reliable is It?
    Am J Respir Crit Care Med. 2017 Sep 11. doi: 10.1164/rccm.201707-1414.
    PubMed     Text format    


  18. LAVAL J, Singh A, Hartl D
    Autophagy Traps Neutrophils into a Protective Alliance during Sepsis.
    Am J Respir Crit Care Med. 2017;196:537-538.
    PubMed     Text format    


    August 2017
  19. HOU J, Chen Q, Wu X, Zhao D, et al
    S1PR3 Signaling Drives Bactericidal Killing and is Required for Survival in Bacterial Sepsis.
    Am J Respir Crit Care Med. 2017 Aug 29. doi: 10.1164/rccm.201701-0241.
    PubMed     Text format     Abstract available


  20. PICKKERS P
    Simultaneously Mounted Pro- and Anti-inflammatory Host Response Relates to the Development of Secondary Infections in Patients with Sepsis.
    Am J Respir Crit Care Med. 2017;196:406-407.
    PubMed     Text format    


  21. WONG HR, Cvijanovich NZ, Anas N, Allen GL, et al
    Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP.
    Am J Respir Crit Care Med. 2017;196:494-501.
    PubMed     Text format     Abstract available


  22. RANDOLPH AG
    A Biosignature Predicting Complicated Course in Children Presenting with Septic Shock. Why PERSEVERE?
    Am J Respir Crit Care Med. 2017;196:411-413.
    PubMed     Text format    


  23. VAN DER POLL T
    Myeloid-derived Suppressor Cells in Sepsis.
    Am J Respir Crit Care Med. 2017;196:256-258.
    PubMed     Text format    


  24. WONG HR, Marshall JC
    Leveraging Transcriptomics to Disentangle Sepsis Heterogeneity.
    Am J Respir Crit Care Med. 2017;196:258-260.
    PubMed     Text format    


  25. UHEL F, Azzaoui I, Gregoire M, Pangault C, et al
    Early Expansion of Circulating Granulocytic Myeloid-derived Suppressor Cells Predicts Development of Nosocomial Infections in Patients with Sepsis.
    Am J Respir Crit Care Med. 2017;196:315-327.
    PubMed     Text format     Abstract available


    July 2017
  26. CLAYTON K, Polak ME, Woelk CH, Elkington P, et al
    Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Than Infectious Diseases.
    Am J Respir Crit Care Med. 2017 Jul 28. doi: 10.1164/rccm.201706-1248.
    PubMed     Text format    


  27. DOS SANTOS C, Heunks L, Wunsch H
    Update in Critical Care 2016.
    Am J Respir Crit Care Med. 2017;196:11-17.
    PubMed     Text format    


    June 2017
  28. RANZANI OT, Prina E, Menendez R, Ceccato A, et al
    New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality: A Validation and Clinical Decision-making Study.
    Am J Respir Crit Care Med. 2017 Jun 14. doi: 10.1164/rccm.201611-2262.
    PubMed     Text format     Abstract available


    May 2017
  29. ZEIN JG, Love TE, Erzurum SC
    Asthma is Associated with a Lower Risk of Sepsis and Sepsis Related Mortality.
    Am J Respir Crit Care Med. 2017 May 22. doi: 10.1164/rccm.201608-1583.
    PubMed     Text format    


  30. SINGER M
    Antibiotics for Sepsis - Does Each Hour Really Count? Or is it Incestuous Amplification?
    Am J Respir Crit Care Med. 2017 May 15. doi: 10.1164/rccm.201703-0621.
    PubMed     Text format    


  31. LIU V, Fielding-Singh V, Iwashyna TJ, Bhattacharya J, et al
    Reply to the Timing of Early Antibiotics and Hospital Mortality in Sepsis - Playing Devil's Advocate.
    Am J Respir Crit Care Med. 2017 May 9. doi: 10.1164/rccm.201704-0774.
    PubMed     Text format    


  32. CHERTOFF J, Ataya A
    The Timing of Early Antibiotics and Hospital Mortality in Sepsis - Playing Devil's Advocate.
    Am J Respir Crit Care Med. 2017 May 9. doi: 10.1164/rccm.201703-0657.
    PubMed     Text format    


    April 2017
  33. MIKACENIC C, Price BL, Harju-Baker S, O'Mahony DS, et al
    A Two Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.
    Am J Respir Crit Care Med. 2017 Apr 18. doi: 10.1164/rccm.201611-2307.
    PubMed     Text format     Abstract available


  34. MORAIS CC, De Santis Santiago RR, Filho JR, Hirota AS, et al
    Monitoring of Pneumothorax Appearance with Electrical Impedance Tomography during Recruitment Maneuvers.
    Am J Respir Crit Care Med. 2017;195:1070-1073.
    PubMed     Text format    


  35. WATERER G, Restrepo MI
    Maladaptive Suppression of Bacterial Clearance in Early Sepsis. Setting the Scene for Failure.
    Am J Respir Crit Care Med. 2017;195:846-847.
    PubMed     Text format    


  36. HARRIS S
    Sepsis-3: Syndromes and Empiricism in the Age of Big Data.
    Am J Respir Crit Care Med. 2017;195:847-849.
    PubMed     Text format    


  37. CHURPEK MM, Snyder A, Han X, Sokol S, et al
    Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit.
    Am J Respir Crit Care Med. 2017;195:906-911.
    PubMed     Text format     Abstract available


    March 2017
  38. PARK SY, Shrestha S, Youn YJ, Kim JK, et al
    Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation During Sepsis.
    Am J Respir Crit Care Med. 2017 Mar 30. doi: 10.1164/rccm.201603-0596.
    PubMed     Text format     Abstract available


  39. LIU VX, Fielding-Singh V, Greene JD, Baker JM, et al
    The Timing of Early Antibiotics and Hospital Mortality in Sepsis.
    Am J Respir Crit Care Med. 2017 Mar 27. doi: 10.1164/rccm.201609-1848.
    PubMed     Text format     Abstract available


    February 2017
  40. LEE S, Nakahira K, Dalli J, Siempos II, et al
    NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
    Am J Respir Crit Care Med. 2017 Feb 28. doi: 10.1164/rccm.201604-0892.
    PubMed     Text format     Abstract available


    January 2017
  41. VAN VUGHT LA, Wiewel MA, Hoogendijk AJ, Frencken JF, et al
    The Host Response in Sepsis Patients Developing Intensive Care Unit-acquired Secondary Infections.
    Am J Respir Crit Care Med. 2017 Jan 20. doi: 10.1164/rccm.201606-1225.
    PubMed     Text format     Abstract available


  42. WALKEY AJ, McManus D
    When Rhythm Changes Cause the Blues: New-Onset Atrial Fibrillation during Sepsis.
    Am J Respir Crit Care Med. 2017;195:152-154.
    PubMed     Text format    


  43. WONG HR, Sweeney TE, Lindsell CJ
    Simplification of a Septic Shock Endotyping Strategy for Clinical Application.
    Am J Respir Crit Care Med. 2017;195:263-265.
    PubMed     Text format    


  44. GEOGHEGAN S, Erviti A, Caballero MT, Vallone F, et al
    Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors.
    Am J Respir Crit Care Med. 2017;195:96-103.
    PubMed     Text format     Abstract available


    December 2016
  45. BURNHAM KL, Davenport EE, Radhakrishnan J, Humburg P, et al
    Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.
    Am J Respir Crit Care Med. 2016 Dec 30. doi: 10.1164/rccm.201608-1685.
    PubMed     Text format     Abstract available


    November 2016
  46. ZHANG H, Li Y, van der Poll T
    Immune Modulation in Sepsis: Is There a Place for Progranulin?
    Am J Respir Crit Care Med. 2016;194:1179-1180.
    PubMed     Text format    


    October 2016
  47. AMATULLAH H, Shan Y, Beauchamp BL, Gali PL, et al
    DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available


    September 2016
  48. SCHULTE K, Linkermann A
    Welcome to the Jungle: The Kidney during Sepsis.
    Am J Respir Crit Care Med. 2016;194:649-50.
    PubMed     Text format    


    July 2016
  49. KLEIN KLOUWENBERG PM, Frencken JF, Kuipers S, Ong DS, et al
    Incidence, Predictors and Outcomes of New-onset Atrial Fibrillation in Critically Ill Patients with Sepsis: a Cohort Study.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available


  50. OU SM, Shih CJ, Chen YT
    Reply: The Methodology of Assessing Long-Term Mortality and Cardiovascular Risks in Survivors of Sepsis.
    Am J Respir Crit Care Med. 2016;194:246.
    PubMed     Text format    


  51. HENRIKSEN DP, Damkier P, Davidsen JR, Laursen CB, et al
    The Methodology of Assessing Long-Term Mortality and Cardiovascular Risks in Survivors of Sepsis.
    Am J Respir Crit Care Med. 2016;194:245-6.
    PubMed     Text format    


  52. STOLK RF, van der Poll T, Angus DC, van der Hoeven JG, et al
    Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available


    June 2016
  53. LEVY MM
    Clarifying Sepsis Management.
    Am J Respir Crit Care Med. 2016;193:1195-6.
    PubMed     Text format    


    May 2016
  54. PRESCOTT HC, Calfee CS, Thompson BT, Angus DC, et al
    Towards Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and ARDS Clinical Trial Design.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available


  55. PATEL J, Taneja A
    Tempering Sepsis-induced Hyperbilirubinemia: Implications for Short- and Long-Term Outcomes.
    Am J Respir Crit Care Med. 2016;193:1183.
    PubMed     Text format    


  56. BARBASH IJ, Kahn JM, Thompson BT
    Medicare's Sepsis Reporting Program: Two Steps Forward, One Step Back.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format    


  57. CALFEE CS
    Precision Medicine: An Opportunity to Improve Outcomes of Patients With Sepsis.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format    


  58. CORTES-PUCH I, Hartog CS
    Change is Not Necessarily Progress: Revision of the Sepsis Definition Should Be Based on New Scientific Insights.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format    


  59. ANGUS DC
    Defining Sepsis: A Case of Bounded Rationality and Fuzzy Thinking?
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format    


  60. SONG Z, Zhang X, Zhang L, Xu F, et al
    Progranulin Plays a Central Role in Host Defense During Sepsis by Promoting Macrophage Recruitment.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available


    March 2016
  61. ROBERTS JA, Abdul-Aziz MH, Davis JS, Dulhunty JM, et al
    Continuous versus Intermittent Beta-lactam Infusion in Severe Sepsis: A Meta-analysis of Individual Patient Data From Randomized Trials.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available


    February 2016
  62. FINFER S, Machado FR
    The Global Epidemiology of Sepsis. Does It Matter That We Know So Little?
    Am J Respir Crit Care Med. 2016;193:228-30.
    PubMed     Text format    


  63. NESSELER N, Launey Y, Aninat C, White J, et al
    Liver Dysfunction Is Associated with Long-Term Mortality in Septic Shock.
    Am J Respir Crit Care Med. 2016;193:335-7.
    PubMed     Text format    


  64. HOSTE EA, De Loor J, Forni LG
    Treating Acute Kidney Injury. One Less Weapon in the Armamentarium?
    Am J Respir Crit Care Med. 2016;193:232-3.
    PubMed     Text format    


  65. KELLUM JA, Chawla LS, Keener C, Singbartl K, et al
    The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock.
    Am J Respir Crit Care Med. 2016;193:281-7.
    PubMed     Text format     Abstract available


    January 2016
  66. OU SM, Chu H, Chao PW, Lee YJ, et al
    Long-term Mortality and Major Adverse Cardiovascular Events in Sepsis Survivors: A Nationwide Population-based Study.
    Am J Respir Crit Care Med. 2016.
    PubMed     Text format     Abstract available



  67. Erratum: Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study.
    Am J Respir Crit Care Med. 2016;193:223-4.
    PubMed     Text format    


  68. SNYDER LD, Chan C, Kwon D, Yi JS, et al
    Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.
    Am J Respir Crit Care Med. 2016;193:78-85.
    PubMed     Text format     Abstract available


    December 2015
  69. LIU VX, Morehouse JW, Marelich GP, Soule J, et al
    Multicenter Implementation of a Treatment Bundle for Sepsis Patients with Intermediate Lactate Values.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  70. CHASTRE J, Luyt CE
    Continuous beta-Lactam Infusion to Optimize Antibiotic Use for Severe Sepsis. A Knife Cutting Water?
    Am J Respir Crit Care Med. 2015;192:1266-8.
    PubMed     Text format    


    October 2015
  71. SMYTH MA, Daniels R, Perkins GD
    Identification of Sepsis among Ward Patients.
    Am J Respir Crit Care Med. 2015;192:910-911.
    PubMed     Text format    


  72. KELLUM JA
    Are Outcomes from Severe Acute Kidney Injury Really Improving?
    Am J Respir Crit Care Med. 2015;192:909-10.
    PubMed     Text format    


  73. CHURPEK MM, Zadravecz FJ, Winslow C, Howell MD, et al
    Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients.
    Am J Respir Crit Care Med. 2015;192:958-64.
    PubMed     Text format     Abstract available


    September 2015
  74. FLEISCHMANN C, Scherag A, Adhikari NK, Hartog CS, et al
    Assessment of Global Incidence and Mortality of Hospital-treated Sepsis - Current Estimates and Limitations.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  75. KAVANAGH BP, Nurok M
    Standardized Intensive Care - Protocol Misalignment and Impact Misattribution.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


    July 2015
  76. DULHUNTY JM, Roberts JA, Davis JS, Webb SA, et al
    A Multicenter Randomized Trial of Continuous versus Intermittent beta-Lactam Infusion in Severe Sepsis.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  77. SHIH CJ, Ou SM, Chen YT
    Reply: Renal Replacement Therapy in Sepsis.
    Am J Respir Crit Care Med. 2015;192:263.
    PubMed     Text format    


  78. SHEN HN
    Renal Replacement Therapy in Sepsis.
    Am J Respir Crit Care Med. 2015;192:263.
    PubMed     Text format    


    June 2015
  79. SAKHUJA A, Kumar G, Gupta S, Mittal T, et al
    Acute Kidney Injury Requiring Dialysis in Severe Sepsis.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  80. SCHORTGEN F, Asfar P
    Update in sepsis and acute kidney injury 2014.
    Am J Respir Crit Care Med. 2015;191:1226-31.
    PubMed     Text format     Abstract available


    May 2015
  81. PRESCOTT HC, Dickson RP, Rogers MA, Langa KM, et al
    Hospitalization Type Predicts Risk of Subsequent Severe Sepsis.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


  82. SASIETA HC, Foley F, Batzlaff CM
    Chlorhexidine Bathing Impact on Infections, Effect of Etomidate on Sepsis Mortality, and Evaluation of Ventilator-associated Conditions.
    Am J Respir Crit Care Med. 2015;191:1197-9.
    PubMed     Text format    


  83. MARSHALL JC
    Understanding the global burden of pediatric sepsis.
    Am J Respir Crit Care Med. 2015;191:1096-8.
    PubMed     Text format    


    April 2015
  84. SHEHABI Y, Rachakonda KS, Bailey MJ, Peake S, et al
    Reply: No Significant Reduction in Antibiotic Treatment Using a Procalcitonin Algorithm with Low Cutoff Value in the Intensive Care Unit?
    Am J Respir Crit Care Med. 2015;191:859-860.
    PubMed     Text format    


  85. KLOOSTERBOER SM, van Zanten AR
    No Significant Reduction in Antibiotic Treatment Using a Procalcitonin Algorithm with Low Cutoff Value in the Intensive Care Unit?
    Am J Respir Crit Care Med. 2015;191:858-859.
    PubMed     Text format    


    March 2015
  86. CILLONIZ C, Albert RK, Liapikou A, Gabarrus A, et al
    The Effect of Macrolide-Resistance on the Presentation and Outcome of Patients Hospitalized for Streptococcus pneumoniae Pneumonia.
    Am J Respir Crit Care Med. 2015.
    PubMed     Text format     Abstract available


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