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Articles published in N Engl J Med

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    November 2023
  1. LINCOFF AM, Brown-Frandsen K, Colhoun HM, Deanfield J, et al
    Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.
    N Engl J Med. 2023 Nov 11. doi: 10.1056/NEJMoa2307563.
    PubMed     Abstract available


  2. MARQUES A, Pereira B, Simonetta-Moreau M, Castelnovo G, et al
    Trial of Botulinum Toxin for Isolated or Essential Head Tremor.
    N Engl J Med. 2023;389:1753-1765.
    PubMed     Abstract available


    October 2023
  3. MACK MJ, Leon MB, Thourani VH, Pibarot P, et al
    Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years.
    N Engl J Med. 2023 Oct 24. doi: 10.1056/NEJMoa2307447.
    PubMed     Abstract available


  4. LINDHOFF-LAST E, Schonborn L, Zaninetti C, Warkentin TE, et al
    Rescue Therapy in Chronic Prothrombotic Autoimmune Anti-PF4 Disorder.
    N Engl J Med. 2023;389:1339-1341.
    PubMed    


    September 2023
  5. STONE PH, Sauer WH
    Harnessing the Deluge of Rhythm-Monitoring Data for the Prevention of Stroke.
    N Engl J Med. 2023;389:1232-1234.
    PubMed    


    August 2023
  6. STAHLI BE, Varbella F, Linke A, Schwarz B, et al
    Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction.
    N Engl J Med. 2023 Aug 27. doi: 10.1056/NEJMoa2307823.
    PubMed     Abstract available


  7. BISCAGLIA S, Guiducci V, Escaned J, Moreno R, et al
    Complete or Culprit-Only PCI in Older Patients with Myocardial Infarction.
    N Engl J Med. 2023 Aug 26. doi: 10.1056/NEJMoa2300468.
    PubMed     Abstract available


  8. THIELE H, Zeymer U, Akin I, Behnes M, et al
    Extracorporeal Life Support in Infarct-Related Cardiogenic Shock.
    N Engl J Med. 2023 Aug 26. doi: 10.1056/NEJMoa2307227.
    PubMed     Abstract available


  9. KIRCHHOF P, Toennis T, Goette A, Camm AJ, et al
    Anticoagulation with Edoxaban in Patients with Atrial High-Rate Episodes.
    N Engl J Med. 2023 Aug 25. doi: 10.1056/NEJMoa2303062.
    PubMed     Abstract available


    July 2023
  10. GRINSPOON SK, Fitch KV, Zanni MV, Fichtenbaum CJ, et al
    Pitavastatin to Prevent Cardiovascular Disease in HIV Infection.
    N Engl J Med. 2023 Jul 23. doi: 10.1056/NEJMoa2304146.
    PubMed     Abstract available


  11. SARRAJ A, Pujara DK, Campbell BC
    Endovascular Thrombectomy for Acute Large Ischemic Strokes. Reply.
    N Engl J Med. 2023;389:89-90.
    PubMed    


  12. KAISER DPO
    Endovascular Thrombectomy for Acute Large Ischemic Strokes.
    N Engl J Med. 2023;389:89.
    PubMed    


  13. PANIGRAHI B
    Endovascular Thrombectomy for Acute Large Ischemic Strokes.
    N Engl J Med. 2023;389:88-89.
    PubMed    


    June 2023
  14. UCHINO K
    Anticoagulation Conundrum in Acute Ischemic Stroke with Atrial Fibrillation.
    N Engl J Med. 2023;388:2479-2480.
    PubMed    


  15. LINCOFF AM, Bhasin S, Flevaris P, Mitchell LM, et al
    Cardiovascular Safety of Testosterone-Replacement Therapy.
    N Engl J Med. 2023 Jun 16. doi: 10.1056/NEJMoa2215025.
    PubMed     Abstract available


  16. MIAH IP, Holl DC, Blaauw J, Lingsma HF, et al
    Dexamethasone versus Surgery for Chronic Subdural Hematoma.
    N Engl J Med. 2023;388:2230-2240.
    PubMed     Abstract available


  17. ROMANO JG, Rundek T
    Expanding Treatment for Acute Ischemic Stroke beyond Revascularization.
    N Engl J Med. 2023;388:2095-2096.
    PubMed    


  18. ZI W, Song J, Kong W, Huang J, et al
    Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion.
    N Engl J Med. 2023;388:2025-2036.
    PubMed     Abstract available


    May 2023
  19. FISCHER U, Koga M, Strbian D, Branca M, et al
    Early versus Later Anticoagulation for Stroke with Atrial Fibrillation.
    N Engl J Med. 2023 May 24. doi: 10.1056/NEJMoa2303048.
    PubMed     Abstract available


    April 2023
  20. O'HARA NN, Stein DM, O'Toole RV
    Aspirin for Thromboprophylaxis after a Fracture. Reply.
    N Engl J Med. 2023;388:e57.
    PubMed    


  21. VAN TWIST DJL, Luu IHY, Ten Cate H
    Aspirin for Thromboprophylaxis after a Fracture.
    N Engl J Med. 2023;388:e57.
    PubMed    


  22. AHUJA T, Green D
    Aspirin for Thromboprophylaxis after a Fracture.
    N Engl J Med. 2023;388:e57.
    PubMed    


  23. YOSHINO T, Yamada Y, Tamura Y
    Aspirin for Thromboprophylaxis after a Fracture.
    N Engl J Med. 2023;388:e57.
    PubMed    


  24. WU XD, Min J
    Aspirin for Thromboprophylaxis after a Fracture.
    N Engl J Med. 2023;388:e57.
    PubMed    


  25. SOURMELIS S, Zagoreos N
    Aspirin for Thromboprophylaxis after a Fracture.
    N Engl J Med. 2023;388:e57.
    PubMed    


    March 2023
  26. JABAGI MJ, Bertrand M, Botton J, Le Vu S, et al
    Stroke, Myocardial Infarction, and Pulmonary Embolism after Bivalent Booster.
    N Engl J Med. 2023 Mar 29. doi: 10.1056/NEJMc2302134.
    PubMed    


  27. NISSEN SE, Lincoff AM, Brennan D, Ray KK, et al
    Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.
    N Engl J Med. 2023 Mar 4. doi: 10.1056/NEJMoa2215024.
    PubMed     Abstract available


    February 2023
  28. SINGHAL AB, Silverman SB, Romero JM, Lang-Orsini M, et al
    Case 6-2023: A 68-Year-Old Man with Recurrent Strokes.
    N Engl J Med. 2023;388:747-757.
    PubMed    


  29. SARRAJ A, Hassan AE, Abraham MG, Ortega-Gutierrez S, et al
    Trial of Endovascular Thrombectomy for Large Ischemic Strokes.
    N Engl J Med. 2023 Feb 10. doi: 10.1056/NEJMoa2214403.
    PubMed     Abstract available


  30. HUO X, Ma G, Tong X, Zhang X, et al
    Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct.
    N Engl J Med. 2023 Feb 10. doi: 10.1056/NEJMoa2213379.
    PubMed     Abstract available


  31. FAYAD P
    Improved Prospects for Thrombectomy in Large Ischemic Stroke.
    N Engl J Med. 2023 Feb 10. doi: 10.1056/NEJMe2300193.
    PubMed    


    January 2023
  32. COSTA M
    Thromboprophylaxis after Extremity Fracture - Time for Aspirin?
    N Engl J Med. 2023;388:274-275.
    PubMed    


  33. O'TOOLE RV, Stein DM, O'Hara NN, Frey KP, et al
    Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture.
    N Engl J Med. 2023;388:203-213.
    PubMed     Abstract available


  34. SABBAGH M, van Dyck CH
    Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke.
    N Engl J Med. 2023 Jan 4:10.1056/NEJMc2215907#sa1. doi: 10.1056/NEJMc2215907.
    PubMed    


  35. REISH NJ, Jamshidi P, Stamm B, Flanagan ME, et al
    Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke.
    N Engl J Med. 2023 Jan 4. doi: 10.1056/NEJMc2215148.
    PubMed    


    December 2022
  36. PELLERIN D, Danzi MC, Wilke C, Renaud M, et al
    Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia.
    N Engl J Med. 2022 Dec 14. doi: 10.1056/NEJMoa2207406.
    PubMed     Abstract available


  37. ISHANI A, Cushman WC, Leatherman SM, Lew RA, et al
    Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events.
    N Engl J Med. 2022 Dec 14. doi: 10.1056/NEJMoa2212270.
    PubMed     Abstract available


    November 2022
  38. FARBER A, Menard MT, Conte MS, Kaufman JA, et al
    Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia.
    N Engl J Med. 2022 Nov 7. doi: 10.1056/NEJMoa2207899.
    PubMed     Abstract available


  39. DAS PRADHAN A, Glynn RJ, Fruchart JC, MacFadyen JG, et al
    Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
    N Engl J Med. 2022 Nov 5. doi: 10.1056/NEJMoa2210645.
    PubMed     Abstract available


    October 2022
  40. ANTMAN EM, Leopold JA, Sauer WH, Zei PC, et al
    Atrial Fibrillation - What Is It and How Is It Treated?
    N Engl J Med. 2022;387:e38.
    PubMed    


  41. JOVIN TG, Li C, Wu L, Wu C, et al
    Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion.
    N Engl J Med. 2022;387:1373-1384.
    PubMed     Abstract available


  42. TAO C, Nogueira RG, Zhu Y, Sun J, et al
    Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion.
    N Engl J Med. 2022;387:1361-1372.
    PubMed     Abstract available


  43. SCHONEWILLE WJ
    Favorable Outcomes in Endovascular Therapy for Basilar-Artery Occlusion.
    N Engl J Med. 2022;387:1428-1429.
    PubMed    


  44. CARROLL JD, Saver JL
    Does Capturing Debris during TAVR Prevent Strokes?
    N Engl J Med. 2022;387:1318-1319.
    PubMed    


    September 2022
  45. KAPADIA SR, Makkar R, Leon M, Abdel-Wahab M, et al
    Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement.
    N Engl J Med. 2022 Sep 17. doi: 10.1056/NEJMoa2204961.
    PubMed     Abstract available


    August 2022
  46. CONNOLLY SJ, Karthikeyan G, Ntsekhe M, Haileamlak A, et al
    Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation.
    N Engl J Med. 2022 Aug 28. doi: 10.1056/NEJMoa2209051.
    PubMed     Abstract available


  47. CASTELLANO JM, Pocock SJ, Bhatt DL, Quesada AJ, et al
    Polypill Strategy in Secondary Cardiovascular Prevention.
    N Engl J Med. 2022 Aug 26. doi: 10.1056/NEJMoa2208275.
    PubMed     Abstract available


    June 2022
  48. YOSHIMURA S, Uchida K, Morimoto T
    Endovascular Therapy for Large Acute Strokes. Reply.
    N Engl J Med. 2022;386:2440-2441.
    PubMed    


  49. MEYER L, Broocks G
    Endovascular Therapy for Large Acute Strokes.
    N Engl J Med. 2022;386:2440.
    PubMed    


    April 2022
  50. SCHWAMM LH
    In Stroke, When Is a Good Outcome Good Enough?
    N Engl J Med. 2022;386:1359-1361.
    PubMed    


  51. LAUZIER DC, Kansagra AP
    Thrombectomy in Acute Ischemic Stroke.
    N Engl J Med. 2022 Apr 2. doi: 10.1056/NEJMicm2116727.
    PubMed    


    February 2022
  52. YOSHIMURA S, Sakai N, Yamagami H, Uchida K, et al
    Endovascular Therapy for Acute Stroke with a Large Ischemic Region.
    N Engl J Med. 2022 Feb 9. doi: 10.1056/NEJMoa2118191.
    PubMed     Abstract available


  53. LECOUFFE NE, Kappelhof M, Roos YBWEM
    Trial of Intravenous Alteplase before Endovascular Treatment for Stroke. Reply.
    N Engl J Med. 2022;386:496-497.
    PubMed    


  54. ZHENG H, Bu S
    Trial of Intravenous Alteplase before Endovascular Treatment for Stroke.
    N Engl J Med. 2022;386:496.
    PubMed    


    December 2021
  55. FESKE SK
    Genetic Profile-Guided Therapy for Stroke?
    N Engl J Med. 2021;385:2576-2577.
    PubMed    


  56. YAMAL JM, Saver JL, Grotta JC
    Trial of Mobile Stroke Units. Reply.
    N Engl J Med. 2021;385.
    PubMed    


  57. GARG R
    Trial of Mobile Stroke Units.
    N Engl J Med. 2021;385.
    PubMed    


  58. MAAS WJ, Lahr MMH, Uyttenboogaart M
    Trial of Mobile Stroke Units.
    N Engl J Med. 2021;385.
    PubMed    


    November 2021
  59. CICCONE A
    Alteplase and Thrombectomy - Not a Bridge to Dismantle.
    N Engl J Med. 2021;385:1904-1905.
    PubMed    


  60. LECOUFFE NE, Kappelhof M, Treurniet KM, Rinkel LA, et al
    A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke.
    N Engl J Med. 2021;385:1833-1844.
    PubMed     Abstract available


  61. SINGH AK, Carroll K, McMurray JJV, Solomon S, et al
    Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis.
    N Engl J Med. 2021 Nov 5. doi: 10.1056/NEJMoa2113380.
    PubMed     Abstract available


  62. SINGH AK, Carroll K, Perkovic V, Solomon S, et al
    Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis.
    N Engl J Med. 2021 Nov 5. doi: 10.1056/NEJMoa2113379.
    PubMed     Abstract available


    October 2021
  63. WANG Y, Meng X, Wang A, Xie X, et al
    Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA.
    N Engl J Med. 2021 Oct 28. doi: 10.1056/NEJMoa2111749.
    PubMed     Abstract available


  64. VALGIMIGLI M, Frigoli E, Heg D, Tijssen J, et al
    Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk.
    N Engl J Med. 2021;385:1643-1655.
    PubMed     Abstract available


    September 2021
  65. LINDSAY ME, Dudzinski DM, Yoon BC, Jaff MR, et al
    Case 30-2021: A 47-Year-Old Man with Recurrent Unilateral Head and Neck Pain.
    N Engl J Med. 2021;385:1317-1325.
    PubMed    


  66. LEES KR
    Does My District Need a Mobile Stroke Unit?
    N Engl J Med. 2021;385:1043-1044.
    PubMed    


  67. GROTTA JC, Yamal JM, Parker SA, Rajan SS, et al
    Prospective, Multicenter, Controlled Trial of Mobile Stroke Units.
    N Engl J Med. 2021;385:971-981.
    PubMed     Abstract available


  68. BELLEY-COTE EP, Connolly SJ, Whitlock RP
    Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. Reply.
    N Engl J Med. 2021;385:1054-1055.
    PubMed    


  69. CHOUDHURY S, Gatherer R, Anwar S
    Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
    N Engl J Med. 2021;385:1054.
    PubMed    


  70. CALISKAN E, Falk V, Emmert MY
    Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
    N Engl J Med. 2021;385:1054.
    PubMed    


  71. COSTA F, Bella GD, Micari A
    Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
    N Engl J Med. 2021;385:1053.
    PubMed    


  72. AUER J, Lamm G
    Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
    N Engl J Med. 2021;385:1053.
    PubMed    


    August 2021
  73. INGELFINGER JR
    Can Salt Substitution Save At-Risk Persons from Stroke?
    N Engl J Med. 2021 Aug 29. doi: 10.1056/NEJMe2112857.
    PubMed    


  74. NEAL B, Wu Y, Feng X, Zhang R, et al
    Effect of Salt Substitution on Cardiovascular Events and Death.
    N Engl J Med. 2021 Aug 29. doi: 10.1056/NEJMoa2105675.
    PubMed     Abstract available


  75. VAN MIEGHEM NM, Unverdorben M, Hengstenberg C, Mollmann H, et al
    Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR.
    N Engl J Med. 2021 Aug 28. doi: 10.1056/NEJMoa2111016.
    PubMed     Abstract available


  76. MATHEW R, Di Santo P, Jung RG, Marbach JA, et al
    Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock.
    N Engl J Med. 2021;385:516-525.
    PubMed     Abstract available


    July 2021
  77. MOSES DA, Metzger SL, Liu JR, Anumanchipalli GK, et al
    Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria.
    N Engl J Med. 2021;385:217-227.
    PubMed     Abstract available


    June 2021
  78. PAGE RL
    The Closing Argument for Surgical Left Atrial Appendage Occlusion.
    N Engl J Med. 2021;384:2154-2155.
    PubMed    


    May 2021
  79. FISHER M
    Endovascular Therapy for Basilar-Artery Occlusion - Still Waiting for Answers.
    N Engl J Med. 2021;384:1954-1955.
    PubMed    


  80. LANGEZAAL LCM, van der Hoeven EJRJ, Mont'Alverne FJA, de Carvalho JJF, et al
    Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion.
    N Engl J Med. 2021;384:1910-1920.
    PubMed     Abstract available


  81. WHITLOCK RP, Belley-Cote EP, Paparella D, Healey JS, et al
    Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
    N Engl J Med. 2021 May 15. doi: 10.1056/NEJMoa2101897.
    PubMed     Abstract available


  82. JONES WS, Mulder H, Wruck LM, Pencina MJ, et al
    Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease.
    N Engl J Med. 2021 May 15. doi: 10.1056/NEJMoa2102137.
    PubMed     Abstract available


    March 2021
  83. KASNER SE, Rhodes JF, Andersen G, Iversen HK, et al
    Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke.
    N Engl J Med. 2021;384:970-971.
    PubMed    


    January 2021
  84. MICHAUD GF, Stevenson WG
    Atrial Fibrillation.
    N Engl J Med. 2021;384:353-361.
    PubMed    


  85. SCHJORRING OL, Klitgaard TL, Perner A, Wetterslev J, et al
    Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure.
    N Engl J Med. 2021 Jan 20. doi: 10.1056/NEJMoa2032510.
    PubMed     Abstract available


  86. BEBELL LM, Gonzalez RG, Barczak AK, Anahtar MN, et al
    Case 1-2021: A 76-Year-Old Woman with Lethargy and Altered Mental Status.
    N Engl J Med. 2021;384:166-176.
    PubMed    


    November 2020
  87. GUIMARAES HP, Lopes RD, de Barros E Silva PGM, Liporace IL, et al
    Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve.
    N Engl J Med. 2020 Nov 14. doi: 10.1056/NEJMoa2029603.
    PubMed     Abstract available


    October 2020
  88. JOHNSTON SC, Amarenco P
    Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. Reply.
    N Engl J Med. 2020;383:1693.
    PubMed    


  89. KAUSHIK A, Deora S, Choudhary R
    Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.
    N Engl J Med. 2020;383:1692-1693.
    PubMed    


  90. AMARENCO P
    Transient Ischemic Attack. Reply.
    N Engl J Med. 2020;383:1598.
    PubMed    


  91. ALPERT JN
    Transient Ischemic Attack.
    N Engl J Med. 2020;383:1597-1598.
    PubMed    


  92. FONSECA AC
    Transient Ischemic Attack.
    N Engl J Med. 2020;383:1597.
    PubMed    


  93. PAPAMITSAKIS N, Moussouttas M
    Transient Ischemic Attack.
    N Engl J Med. 2020;383:1596-1597.
    PubMed    


  94. SHIL AB
    Transient Ischemic Attack.
    N Engl J Med. 2020;383:1596.
    PubMed    


  95. MUKERJI SS, Ard KL, Schaefer PW, Branda JA, et al
    Case 32-2020: A 63-Year-Old Man with Confusion, Fatigue, and Garbled Speech.
    N Engl J Med. 2020;383:1578-1586.
    PubMed    


    August 2020
  96. OKUMURA K, Akao M, Yoshida T, Kawata M, et al
    Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation.
    N Engl J Med. 2020 Aug 30. doi: 10.1056/NEJMoa2012883.
    PubMed     Abstract available


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