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Tuberculosis

Free Subscription Articles published in Antimicrob Agents Chemother Retrieve available abstracts of 156 articles: HTML format

Single Articles

April 2024
1. KENGO A, Nabeemeeah F, Denti P, Sabet R, et al
   Assessing potential drug-drug interactions between clofazimine and other frequently used agents to treat drug-resistant tuberculosis.
   Antimicrob Agents Chemother. 2024 Apr 10:e0158323. doi: 10.1128/aac.01583.
   PubMed     Abstract available
   
   
   
2. POONAWALA H, Zhang Y, Kuchibhotla S, Green AG, et al
   Transcriptomic responses to antibiotic exposure in Mycobacterium tuberculosis.
   Antimicrob Agents Chemother. 2024 Apr 8:e0118523. doi: 10.1128/aac.01185.
   PubMed     Abstract available
   
   
   March 2024
3. LYONS MA, Obregon-Henao A, Ramey ME, Bauman AA, et al
   Use of multiple pharmacodynamic measures to deconstruct the Nix-TB regimen in a short-course murine model of tuberculosis.
   Antimicrob Agents Chemother. 2024 Mar 19:e0101023. doi: 10.1128/aac.01010.
   PubMed     Abstract available
   
   
   
4. VILLELLAS C, Stevenaert F, Remmerie B, Andries K, et al
   Sub-MIC levels of bedaquiline and clofazimine can select Mycobacterium tuberculosis mutants with increased MIC.
   Antimicrob Agents Chemother. 2024 Mar 12:e0127523. doi: 10.1128/aac.01275.
   PubMed     Abstract available
   
   
   February 2024
5. OLIVENCA F, Pires D, Silveiro C, Gama B, et al
   Ethambutol and meropenem/clavulanate synergy promotes enhanced extracellular and intracellular killing of Mycobacterium tuberculosis.
   Antimicrob Agents Chemother. 2024 Feb 27:e0158623. doi: 10.1128/aac.01586.
   PubMed     Abstract available
   
   
   
6. LI S-Y, Tyagi S, Soni H, Betoudji F, et al
   Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis.
   Antimicrob Agents Chemother. 2024 Feb 20:e0156223. doi: 10.1128/aac.01562.
   PubMed     Abstract available
   
   
   January 2024
7. SINGH P, Kumar A, Sharma P, Chugh S, et al
   Identification and optimization of pyridine carboxamide-based scaffold as a drug lead for Mycobacterium tuberculosis.
   Antimicrob Agents Chemother. 2024 Jan 9:e0076623. doi: 10.1128/aac.00766.
   PubMed     Abstract available
   
   
   December 2023
8. RUELAS CASTILLO J, Neupane P, Karanika S, Krug S, et al
   The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model.
   Antimicrob Agents Chemother. 2023 Dec 22:e0104323. doi: 10.1128/aac.01043.
   PubMed     Abstract available
   
   
   
9. SINGH S, Gumbo T, Boorgula GD, Thomas TA, et al
   Omadacycline pharmacokinetics/pharmacodynamics and efficacy against multidrug-resistant Mycobacterium tuberculosis in the hollow fiber system model.
   Antimicrob Agents Chemother. 2023 Dec 22:e0108023. doi: 10.1128/aac.01080.
   PubMed     Abstract available
   
   
   
10. ALI AM, P Solans B, Hesseling AC, Winckler J, et al
    Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis.
    Antimicrob Agents Chemother. 2023 Dec 19:e0079423. doi: 10.1128/aac.00794.
    PubMed     Abstract available
    
    
    
11. PANDEY S, Vilcheze C, Werngren J, Bainomugisa A, et al
    Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2023 Dec 1:e0109623. doi: 10.1128/aac.01096.
    PubMed     Abstract available
    
    
    November 2023
12. VAN DER LAAN LE, Garcia-Prats AJ, McIlleron H, Abdelwahab MT, et al
    Optimizing dosing of the cycloserine pro-drug terizidone in children with rifampicin-resistant tuberculosis.
    Antimicrob Agents Chemother. 2023 Nov 16:e0061123. doi: 10.1128/aac.00611.
    PubMed     Abstract available
    
    
    
13. ALMEIDA D, Li S-Y, Lee J, Hafkin B, et al
    Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis.
    Antimicrob Agents Chemother. 2023 Nov 15:e0078923. doi: 10.1128/aac.00789.
    PubMed     Abstract available
    
    
    
14. LANNI F, Antilus Sainte R, Hansen M Jr, Parigi P, et al
    A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease.
    Antimicrob Agents Chemother. 2023 Nov 15:e0067123. doi: 10.1128/aac.00671.
    PubMed     Abstract available
    
    
    October 2023
15. VAN SCHALKWYK M, Bekker A, Decloedt E, Wang J, et al
    Pharmacokinetics and safety of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum: results from IMPAACT P1026s.
    Antimicrob Agents Chemother. 2023 Oct 26:e0073723. doi: 10.1128/aac.00737.
    PubMed     Abstract available
    
    
    
16. XIE YL, Modi N, Handler D, Yu S, et al
    Simplified urine-based method to detect rifampin underexposure in adults with tuberculosis: a prospective diagnostic accuracy study.
    Antimicrob Agents Chemother. 2023 Oct 25:e0093223. doi: 10.1128/aac.00932.
    PubMed     Abstract available
    
    
    
17. KENGO A, Nabisere R, Gausi K, Musaazi J, et al
    Dolutegravir pharmacokinetics in Ugandan patients with TB and HIV receiving standard- versus high-dose rifampicin.
    Antimicrob Agents Chemother. 2023 Oct 18:e0043023. doi: 10.1128/aac.00430.
    PubMed     Abstract available
    
    
    
18. KENGO A, Gausi K, Nabisere R, Musaazi J, et al
    Unexpectedly low drug exposures among Ugandan patients with TB and HIV receiving high-dose rifampicin.
    Antimicrob Agents Chemother. 2023 Oct 18:e0043123. doi: 10.1128/aac.00431.
    PubMed     Abstract available
    
    
    
19. RAMEY ME, Kaya F, Bauman AA, Massoudi LM, et al
    Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
    Antimicrob Agents Chemother. 2023 Oct 4:e0059723. doi: 10.1128/aac.00597.
    PubMed     Abstract available
    
    
    September 2023
20. STEMKENS R, Jager V, Dawson R, Diacon AH, et al
    Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis.
    Antimicrob Agents Chemother. 2023 Sep 28:e0068323. doi: 10.1128/aac.00683.
    PubMed     Abstract available
    
    
    
21. MEIKLE V, Zhang L, Niederweis M
    Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2023 Sep 7:e0162922. doi: 10.1128/aac.01629.
    PubMed     Abstract available
    
    
    August 2023
22. WALTER ND, Ernest JP, Dide-Agossou C, Bauman AA, et al
    Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
    Antimicrob Agents Chemother. 2023 Aug 11:e0028423. doi: 10.1128/aac.00284.
    PubMed     Abstract available
    
    
    June 2023
23. ALI AM, Radtke KK, Hesseling AC, Winckler J, et al
    QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies.
    Antimicrob Agents Chemother. 2023 Jun 26:e0144822. doi: 10.1128/aac.01448.
    PubMed     Abstract available
    
    
    
24. GRIES R, Dal Molin M, Chhen J, van Gumpel E, et al
    Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome bc(1) Complex.
    Antimicrob Agents Chemother. 2023 Jun 26:e0025123. doi: 10.1128/aac.00251.
    PubMed     Abstract available
    
    
    
25. VAN DER LAAN LE, Garcia-Prats AJ, Schaaf HS, Chirehwa M, et al
    Erratum for van der Laan et al., "Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis".
    Antimicrob Agents Chemother. 2023 Jun 20:e0072023. doi: 10.1128/aac.00720.
    PubMed    
    
    
    
26. CHANG YS, Li SY, Pertinez H, Betoudji F, et al
    Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy.
    Antimicrob Agents Chemother. 2023 Jun 14:e0048123. doi: 10.1128/aac.00481.
    PubMed     Abstract available
    
    
    May 2023
27. XU J, Li D, Shi J, Wang B, et al
    Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis.
    Antimicrob Agents Chemother. 2023 May 31:e0153222. doi: 10.1128/aac.01532.
    PubMed     Abstract available
    
    
    
28. DAWSON R, Diacon AH, Narunsky K, De Jager VR, et al
    Phase I Single Ascending Dose and Food Effect Study in Healthy Adults and Phase I/IIa Multiple Ascending Dose Study in Patients with Pulmonary Tuberculosis to Assess Pharmacokinetics, Bactericidal Activity, Tolerability, and Safety of OPC-167832.
    Antimicrob Agents Chemother. 2023 May 23:e0147722. doi: 10.1128/aac.01477.
    PubMed     Abstract available
    
    
    
29. MATHIYAZAKAN V, Wong CF, Harikishore A, Pethe K, et al
    Cryo-Electron Microscopy Structure of the Mycobacterium tuberculosis Cytochrome bcc:aa(3) Supercomplex and a Novel Inhibitor Targeting Subunit Cytochrome cI.
    Antimicrob Agents Chemother. 2023 May 9:e0153122. doi: 10.1128/aac.01531.
    PubMed     Abstract available
    
    
    April 2023
30. ZHU Y, Zhu L, Davies Forsman L, Paues J, et al
    Population Pharmacokinetics and Dose Evaluation of Cycloserine among Patients with Multidrug-Resistant Tuberculosis under Standardized Treatment Regimens.
    Antimicrob Agents Chemother. 2023 Apr 25:e0170022. doi: 10.1128/aac.01700.
    PubMed     Abstract available
    
    
    
31. NEGATU DA, Aragaw WW, Cangialosi J, Dartois V, et al
    Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections.
    Antimicrob Agents Chemother. 2023;67:e0165522.
    PubMed     Abstract available
    
    
    
32. LIU Y, Moodley M, Pasipanodya JG, Gumbo T, et al
    Determining the Delamanid Pharmacokinetics/Pharmacodynamics Susceptibility Breakpoint Using Monte Carlo Experiments.
    Antimicrob Agents Chemother. 2023;67:e0140122.
    PubMed     Abstract available
    
    
    March 2023
33. ECKHARDT E, Li Y, Mamerow S, Schinkothe J, et al
    Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model.
    Antimicrob Agents Chemother. 2023 Mar 28:e0143822. doi: 10.1128/aac.01438.
    PubMed     Abstract available
    
    
    
34. LI SY, Converse PJ, Betoudji F, Lee J, et al
    Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model.
    Antimicrob Agents Chemother. 2023 Mar 15:e0003523. doi: 10.1128/aac.00035.
    PubMed     Abstract available
    
    
    
35. ISMAIL N, Dippenaar A, Warren RM, Peters RPH, et al
    Emergence of Canonical and Noncanonical Genomic Variants following In Vitro Exposure of Clinical Mycobacterium tuberculosis Strains to Bedaquiline or Clofazimine.
    Antimicrob Agents Chemother. 2023 Mar 9:e0136822. doi: 10.1128/aac.01368.
    PubMed     Abstract available
    
    
    February 2023
36. ABDELGAWAD N, Tshavhungwe MP, Rohlwink U, McIlleron H, et al
    Population Pharmacokinetic Analysis of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis.
    Antimicrob Agents Chemother. 2023 Feb 23:e0147422. doi: 10.1128/aac.01474.
    PubMed     Abstract available
    
    
    
37. ALMEIDA DV, Converse PJ, Nuermberger EL
    Mutations in Rv0678 Reduce Susceptibility of Mycobacterium tuberculosis to the DprE1 Inhibitor TBA-7371.
    Antimicrob Agents Chemother. 2023 Feb 14:e0005223. doi: 10.1128/aac.00052.
    PubMed    
    
    
    
38. CHIREHWA MT, Resendiz-Galvan JE, Court R, De Kock M, et al
    Optimizing Moxifloxacin Dose in MDR-TB Participants with or without Efavirenz Coadministration Using Population Pharmacokinetic Modeling.
    Antimicrob Agents Chemother. 2023 Feb 6:e0142622. doi: 10.1128/aac.01426.
    PubMed     Abstract available
    
    
    January 2023
39. LIU H, Zhu H, Fu L, Zhang W, et al
    Efficacy of Replacing Linezolid with OTB-658 in Anti-Tuberculosis Regimens in Murine Models.
    Antimicrob Agents Chemother. 2023 Jan 9:e0139922. doi: 10.1128/aac.01399.
    PubMed     Abstract available
    
    
    
40. REICHLEN MJ, Born SEM, Lyons MA, Rossmassler K, et al
    Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency.
    Antimicrob Agents Chemother. 2023 Jan 9:e0148322. doi: 10.1128/aac.01483.
    PubMed     Abstract available
    
    
    
41. JARRETT RT, van der Heijden Y, Shotwell MS, Chihota V, et al
    High Isoniazid Exposures When Administered with Rifapentine Once Weekly for Latent Tuberculosis in Individuals with Human Immunodeficiency Virus.
    Antimicrob Agents Chemother. 2023 Jan 9:e0129722. doi: 10.1128/aac.01297.
    PubMed     Abstract available
    
    
    
42. BROWN KL, Wilburn KM, Montague CR, Grigg JC, et al
    Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in Mycobacterium tuberculosis by the Novel Drug Candidate GSK2556286.
    Antimicrob Agents Chemother. 2023 Jan 5:e0129422. doi: 10.1128/aac.01294.
    PubMed     Abstract available
    
    
    December 2022
43. KIM J, Choi J, Kang H, Ahn J, et al
    Safety, Tolerability, Pharmacokinetics, and Metabolism of Telacebec (Q203) for the Treatment of Tuberculosis: a Randomized, Placebo-Controlled, Multiple Ascending Dose Phase 1B Trial.
    Antimicrob Agents Chemother. 2022 Dec 12:e0112322. doi: 10.1128/aac.01123.
    PubMed     Abstract available
    
    
    November 2022
44. LIU Y, Shi J, Li L, Wu T, et al
    Spontaneous Mutational Patterns and Novel Mutations for Delamanid Resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2022 Nov 30:e0053122. doi: 10.1128/aac.00531.
    PubMed     Abstract available
    
    
    
45. WONG CF, Saw WG, Basak S, Sano M, et al
    Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors.
    Antimicrob Agents Chemother. 2022 Nov 29:e0105622. doi: 10.1128/aac.01056.
    PubMed     Abstract available
    
    
    
46. MANSJO M, Karlsson Lindsjo O, Gronfors Seeth C, Groenheit R, et al
    The ddn Trp20Stop Mutation and Its Association with Lineage 4.5 and Resistance to Delamanid and Pretomanid in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2022 Nov 21:e0102622. doi: 10.1128/aac.01026.
    PubMed     Abstract available
    
    
    
47. LYONS MA
    Pharmacodynamics and Bactericidal Activity of Combination Regimens in Pulmonary Tuberculosis: Application to Bedaquiline-Pretomanid-Pyrazinamide.
    Antimicrob Agents Chemother. 2022 Nov 15:e0089822. doi: 10.1128/aac.00898.
    PubMed     Abstract available
    
    
    
48. SARATHY JP, Zimmerman MD, Gengenbacher M, Dartois V, et al
    Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro.
    Antimicrob Agents Chemother. 2022 Nov 9:e0123722. doi: 10.1128/aac.01237.
    PubMed     Abstract available
    
    
    
49. MON AS, Ei PW, Htwe MM, Nyunt MH, et al
    First Detection of Mycobacterium tuberculosis Clinical Isolates Harboring I491F Borderline Resistance rpoB Mutation in Myanmar.
    Antimicrob Agents Chemother. 2022 Nov 7:e0092522. doi: 10.1128/aac.00925.
    PubMed    
    
    
    
50. NGUYEN TQ, Hanh BTB, Jeon S, Heo BE, et al
    Synergistic Effect of Q203 Combined with PBTZ169 against Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2022 Nov 2:e0044822. doi: 10.1128/aac.00448.
    PubMed     Abstract available
    
    
    October 2022
51. AL-ZUBAIDI A, Cheung CY, Cook GM, Taiaroa G, et al
    RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria.
    Antimicrob Agents Chemother. 2022;66:e0209121.
    PubMed     Abstract available
    
    
    
52. PI R, Chen X, Meng J, Liu Q, et al
    Drug Degradation Caused by mce3R Mutations Confers Contezolid (MRX-I) Resistance in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2022 Oct 3:e0103422. doi: 10.1128/aac.01034.
    PubMed     Abstract available
    
    
    September 2022
53. YAMADA W, Kim S, Almoslem M, Kim S, et al
    Combination Therapy to Kill Mycobacterium tuberculosis in Its Nonreplicating Persister Phenotype.
    Antimicrob Agents Chemother. 2022 Sep 27:e0069522. doi: 10.1128/aac.00695.
    PubMed     Abstract available
    
    
    
54. LIU F, Gao J, Gao M, Liu Y, et al
    Development and Validation of a Nomogram for Prediction of QT Interval Prolongation in Patients Administered Bedaquiline-Containing Regimens in China: a Modeling Study.
    Antimicrob Agents Chemother. 2022;66:e0203321.
    PubMed     Abstract available
    
    
    
55. ZOU J, Chen S, Rao W, Fu L, et al
    Population Pharmacokinetic Modeling of Bedaquiline among Multidrug-Resistant Pulmonary Tuberculosis Patients from China.
    Antimicrob Agents Chemother. 2022 Sep 15:e0081122. doi: 10.1128/aac.00811.
    PubMed     Abstract available
    
    
    
56. SUNDELL J, Bienvenu E, Birgersson S, Abelo A, et al
    Effects of Enzyme Induction and Polymorphism on the Pharmacokinetics of Isoniazid and Rifampin in Tuberculosis/HIV Patients.
    Antimicrob Agents Chemother. 2022 Sep 7:e0227721. doi: 10.1128/aac.02277.
    PubMed     Abstract available
    
    
    August 2022
57. KIM LH, Kang SM, Whang J, Kwon KW, et al
    Novel Antibacterial Activity of Febuxostat, an FDA-Approved Antigout Drug against Mycobacterium tuberculosis Infection.
    Antimicrob Agents Chemother. 2022 Aug 30:e0076222. doi: 10.1128/aac.00762.
    PubMed     Abstract available
    
    
    
58. SHEE S, Singh S, Tripathi A, Thakur C, et al
    Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species.
    Antimicrob Agents Chemother. 2022 Aug 17:e0059222. doi: 10.1128/aac.00592.
    PubMed     Abstract available
    
    
    
59. GEBERETSADIK G, Inaizumi A, Nishiyama A, Yamaguchi T, et al
    Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.
    Antimicrob Agents Chemother. 2022 Aug 15:e0017122. doi: 10.1128/aac.00171.
    PubMed     Abstract available
    
    
    
60. BRUNAUGH AD, Walz A, Warnken Z, Pearce C, et al
    Respirable Clofazimine Particles Produced by Air Jet Milling Technique Are Efficacious in Treatment of BALB/c Mice with Chronic Mycobacterium tuberculosis Infection.
    Antimicrob Agents Chemother. 2022 Aug 9:e0018622. doi: 10.1128/aac.00186.
    PubMed     Abstract available
    
    
    
61. BARNIER JP, Saidjalolov S, Bouchet F, Mayer L, et al
    Modulation of the Specificity of Carbapenems and Diazabicyclooctanes for Selective Activity against Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2022 Aug 9:e0235721. doi: 10.1128/aac.02357.
    PubMed     Abstract available
    
    
    
62. YUN HY, Chang MJ, Jung H, Chang V, et al
    Prothionamide Dose Optimization Using Population Pharmacokinetics for Multidrug-Resistant Tuberculosis Patients.
    Antimicrob Agents Chemother. 2022 Aug 8:e0189321. doi: 10.1128/aac.01893.
    PubMed     Abstract available
    
    
    
63. DING Y, Zhu H, Fu L, Zhang W, et al
    Superior Efficacy of a TBI-166, Bedaquiline, and Pyrazinamide Combination Regimen in a Murine Model of Tuberculosis.
    Antimicrob Agents Chemother. 2022 Aug 4:e0065822. doi: 10.1128/aac.00658.
    PubMed     Abstract available
    
    
    
64. POULTON NC, Azadian ZA, DeJesus MA, Rock JM, et al
    Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis.
    Antimicrob Agents Chemother. 2022 Aug 3:e0090422. doi: 10.1128/aac.00904.
    PubMed     Abstract available
    
    
    
65. GRACIAA DS, Kipiani M, Magee MJ, Mikiashvili L, et al
    Linezolid Exposure Is Associated with Cytopenias in Patients Treated for Multidrug-Resistant Tuberculosis.
    Antimicrob Agents Chemother. 2022 Aug 2:e0040822. doi: 10.1128/aac.00408.
    PubMed     Abstract available
    
    
    July 2022
66. SHELTON CD, McNeil MB, Early JV, Ioerger TR, et al
    Correction for Shelton et al., "Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis".
    Antimicrob Agents Chemother. 2022 Jul 25:e0096222. doi: 10.1128/aac.00962.
    PubMed    
    
    
    
67. MTSHALI S, Jacobs BA
    A Comparative Analysis of Physiologically Based Pharmacokinetic Models for Human Immunodeficiency Virus and Tuberculosis Infections.
    Antimicrob Agents Chemother. 2022 Jul 19:e0027422. doi: 10.1128/aac.00274.
    PubMed     Abstract available
    
    
    
68. MEHTA K, Guo T, Wallis RS, van der Graaf PH, et al
    Quantitative Systems Pharmacology Modeling Framework of Autophagy in Tuberculosis: Application to Adjunctive Metformin Host-Directed Therapy.
    Antimicrob Agents Chemother. 2022 Jul 14:e0036622. doi: 10.1128/aac.00366.
    PubMed     Abstract available
    
    
    June 2022
69. RIVIERE E, Verboven L, Dippenaar A, Goossens S, et al
    Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage.
    Antimicrob Agents Chemother. 2022 Jun 27:e0032222. doi: 10.1128/aac.00322.
    PubMed     Abstract available
    
    
    
70. ABOLHASSANI-CHIMEH R, Akkerman OW, Saktiawati AMI, Punt NC, et al
    Population Pharmacokinetic Modelling and Limited Sampling Strategies for Therapeutic Drug Monitoring of Pyrazinamide in Patients with Tuberculosis.
    Antimicrob Agents Chemother. 2022 Jun 21:e0000322. doi: 10.1128/aac.00003.
    PubMed     Abstract available
    
    
    
71. WALTER K, Kokesch-Himmelreich J, Treu A, Waldow F, et al
    Interleukin-13-Overexpressing Mice Represent an Advanced Preclinical Model for Detecting the Distribution of Antimycobacterial Drugs within Centrally Necrotizing Granulomas.
    Antimicrob Agents Chemother. 2022;66:e0158821.
    PubMed     Abstract available
    
    
    May 2022
72. NUERMBERGER EL, Martinez-Martinez MS, Sanz O, Urones B, et al
    GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
    Antimicrob Agents Chemother. 2022 May 24:e0013222. doi: 10.1128/aac.00132.
    PubMed     Abstract available
    
    
    
73. KAWUMA AN, Wasmann RE, Dooley KE, Boffito M, et al
    Population Pharmacokinetic Model and Alternative Dosing Regimens for Dolutegravir Coadministered with Rifampicin.
    Antimicrob Agents Chemother. 2022 May 23:e0021522. doi: 10.1128/aac.00215.
    PubMed     Abstract available
    
    
    
74. PAUL A, Nair RR, Jakkala K, Pradhan A, et al
    Elevated Levels of Three Reactive Oxygen Species and Fe(II) in the Antibiotic-Surviving Population of Mycobacteria Facilitate De Novo Emergence of Genetic Resisters to Antibiotics.
    Antimicrob Agents Chemother. 2022;66:e0228521.
    PubMed     Abstract available
    
    
    
75. CONKLE-GUTIERREZ D, Kim C, Ramirez-Busby SM, Modlin SJ, et al
    Distribution of Common and Rare Genetic Markers of Second-Line-Injectable-Drug Resistance in Mycobacterium tuberculosis Revealed by a Genome-Wide Association Study.
    Antimicrob Agents Chemother. 2022 May 9:e0207521. doi: 10.1128/aac.02075.
    PubMed     Abstract available
    
    
    
76. VAN DER LAAN LE, Garcia-Prats AJ, Schaaf HS, Chirehwa M, et al
    Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis.
    Antimicrob Agents Chemother. 2022 May 4:e0226421. doi: 10.1128/aac.02264.
    PubMed     Abstract available
    
    
    April 2022
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