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Articles published in Proc Natl Acad Sci U S A

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    June 2018
  1. GERRICK ER, Barbier T, Chase MR, Xu R, et al
    Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response.
    Proc Natl Acad Sci U S A. 2018 Jun 5. pii: 1718003115.
    PubMed     Text format     Abstract available


    March 2018
  2. CROWE AM, Workman SD, Watanabe N, Worrall LJ, et al
    IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.
    Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 1717015115.
    PubMed     Text format     Abstract available


  3. ARREGUI S, Iglesias MJ, Samper S, Marinova D, et al
    Data-driven model for the assessment of Mycobacterium tuberculosis transmission in evolving demographic structures.
    Proc Natl Acad Sci U S A. 2018 Mar 21. pii: 1720606115.
    PubMed     Text format     Abstract available


    January 2018
  4. VILCHEZE C, Weinrick B, Leung LW, Jacobs WR Jr., et al
    Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.
    Proc Natl Acad Sci U S A. 2018 Jan 30. pii: 1721545115.
    PubMed     Text format     Abstract available


  5. ESMAIL H, Lai RP, Lesosky M, Wilkinson KA, et al
    Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis.
    Proc Natl Acad Sci U S A. 2018 Jan 16. pii: 1711853115.
    PubMed     Text format     Abstract available


    December 2017
  6. GAUTAM US, Foreman TW, Bucsan AN, Veatch AV, et al
    In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Dec 18. pii: 1711373114.
    PubMed     Text format     Abstract available


    November 2017
  7. CHANCELLOR A, Tocheva AS, Cave-Ayland C, Tezera L, et al
    CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.
    Proc Natl Acad Sci U S A. 2017 Nov 20. pii: 201708252.
    PubMed     Text format     Abstract available


    October 2017

  8. Correction for Koster et al., Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.
    Proc Natl Acad Sci U S A. 2017 Oct 30. pii: 201718266.
    PubMed     Text format    


  9. BLANC L, Gilleron M, Prandi J, Song OR, et al
    Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.
    Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201707840.
    PubMed     Text format     Abstract available


    September 2017
  10. KOSTER S, Upadhyay S, Chandra P, Papavinasasundaram K, et al
    Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.
    Proc Natl Acad Sci U S A. 2017 Sep 27. pii: 201707792.
    PubMed     Text format     Abstract available


    July 2017
  11. PHAM TV, Murkin AS, Moynihan MM, Harris L, et al
    Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Jul 5. pii: 201706134.
    PubMed     Text format     Abstract available


    June 2017
  12. KALIA NP, Hasenoehrl EJ, Ab Rahman NB, Koh VH, et al
    Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.
    Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201706139.
    PubMed     Text format     Abstract available


    May 2017
  13. SAITO K, Warrier T, Somersan-Karakaya S, Kaminski L, et al
    Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.
    Proc Natl Acad Sci U S A. 2017 May 30. pii: 201705385.
    PubMed     Text format     Abstract available


    April 2017
  14. LI H, Wang XX, Wang B, Fu L, et al
    Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Apr 24. pii: 201611776.
    PubMed     Text format     Abstract available


  15. VILCHEZE C, Hartman T, Weinrick B, Jain P, et al
    Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Apr 10. pii: 201704376.
    PubMed     Text format     Abstract available


    March 2017
  16. LIU C, Zhao Z, Fan J, Lyon CJ, et al
    Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring.
    Proc Natl Acad Sci U S A. 2017 Mar 27. pii: 201621360.
    PubMed     Text format     Abstract available


  17. PUCKETT S, Trujillo C, Wang Z, Eoh H, et al
    Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2017 Mar 6. pii: 201617655.
    PubMed     Text format     Abstract available


    January 2017
  18. TROEGELER A, Mercier I, Cougoule C, Pietretti D, et al
    C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.
    Proc Natl Acad Sci U S A. 2017 Jan 9. pii: 201613254.
    PubMed     Text format     Abstract available


    November 2016
  19. ELDHOLM V, Pettersson JH, Brynildsrud OB, Kitchen A, et al
    Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Nov 21. pii: 201611283.
    PubMed     Text format     Abstract available


  20. LUPOLI TJ, Fay A, Adura C, Glickman MS, et al
    Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.
    Proc Natl Acad Sci U S A. 2016 Nov 21. pii: 201617644.
    PubMed     Text format     Abstract available


  21. SOUTTER HH, Centrella P, Clark MA, Cuozzo JW, et al
    Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
    Proc Natl Acad Sci U S A. 2016 Nov 18. pii: 201610978.
    PubMed     Text format     Abstract available


    September 2016
  22. ROTHCHILD AC, Sissons JR, Shafiani S, Plaisier C, et al
    MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Sep 28. pii: 201608255.
    PubMed     Text format     Abstract available


  23. FOREMAN TW, Mehra S, LoBato DN, Malek A, et al
    CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.
    Proc Natl Acad Sci U S A. 2016 Sep 6. pii: 201611987.
    PubMed     Text format     Abstract available


    August 2016
  24. BORITSCH EC, Khanna V, Pawlik A, Honore N, et al
    Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria.
    Proc Natl Acad Sci U S A. 2016 Aug 15. pii: 201604921.
    PubMed     Text format     Abstract available


    July 2016
  25. CHISHOLM RH, Trauer JM, Curnoe D, Tanaka MM, et al
    Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Jul 25. pii: 201603224.
    PubMed     Text format     Abstract available


  26. WARRIER T, Kapilashrami K, Argyrou A, Ioerger TR, et al
    N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Jul 18. pii: 201606590.
    PubMed     Text format     Abstract available


    June 2016
  27. KASBEKAR M, Fischer G, Mott BT, Yasgar A, et al
    Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
    Proc Natl Acad Sci U S A. 2016 Jun 20. pii: 201600630.
    PubMed     Text format     Abstract available


    April 2016

  28. Correction for Bai et al., Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Apr 18. pii: 201604955.
    PubMed     Text format    


  29. MATSUI T, Nambu S, Goulding CW, Takahashi S, et al
    Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation.
    Proc Natl Acad Sci U S A. 2016;113:3779-84.
    PubMed     Text format     Abstract available


    March 2016
  30. SILVA A, Lee BY, Clemens DL, Kee T, et al
    Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model.
    Proc Natl Acad Sci U S A. 2016 Mar 28. pii: 201600812.
    PubMed     Text format     Abstract available


  31. BAI L, Hu K, Wang T, Jastrab JM, et al
    Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Mar 21. pii: 201512094.
    PubMed     Text format     Abstract available


    January 2016
  32. BLOWER TR, Williamson BH, Kerns RJ, Berger JM, et al
    Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2016 Jan 20. pii: 201525047.
    PubMed     Text format     Abstract available


  33. ALDRED KJ, Blower TR, Kerns RJ, Berger JM, et al
    Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.
    Proc Natl Acad Sci U S A. 2016 Jan 20. pii: 201525055.
    PubMed     Text format     Abstract available


  34. TUFARIELLO JM, Chapman JR, Kerantzas CA, Wong KW, et al
    Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
    Proc Natl Acad Sci U S A. 2016 Jan 4. pii: 201523321.
    PubMed     Text format     Abstract available


    October 2015

  35. Correction for Maksymiuk et al., E1 of alpha-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
    Proc Natl Acad Sci U S A. 2015 Oct 26. pii: 201519907.
    PubMed     Text format    


  36. LEE RS, Radomski N, Proulx JF, Levade I, et al
    Population genomics of Mycobacterium tuberculosis in the Inuit.
    Proc Natl Acad Sci U S A. 2015 Oct 19. pii: 201507071.
    PubMed     Text format     Abstract available


  37. KIESER KJ, Baranowski C, Chao MC, Long JE, et al
    Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility.
    Proc Natl Acad Sci U S A. 2015 Oct 5. pii: 201514135.
    PubMed     Text format     Abstract available


  38. MAKSYMIUK C, Balakrishnan A, Bryk R, Rhee KY, et al
    E1 of alpha-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
    Proc Natl Acad Sci U S A. 2015 Oct 1. pii: 201510932.
    PubMed     Text format     Abstract available


    August 2015
  39. AWUH JA, Haug M, Mildenberger J, Marstad A, et al
    Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.
    Proc Natl Acad Sci U S A. 2015;112:E4272-80.
    PubMed     Text format     Abstract available


  40. TOPILINA NI, Green CM, Jayachandran P, Kelley DS, et al
    SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses.
    Proc Natl Acad Sci U S A. 2015 Aug 3. pii: 201512777.
    PubMed     Text format     Abstract available


    July 2015
  41. BERNEY M, Berney-Meyer L, Wong KW, Chen B, et al
    Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2015 Jul 28. pii: 201513033.
    PubMed     Text format     Abstract available


  42. WANG Y, Zhong H, Xie X, Chen CY, et al
    Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.
    Proc Natl Acad Sci U S A. 2015 Jul 6. pii: 201501662.
    PubMed     Text format     Abstract available


    June 2015
  43. LUO T, Comas I, Luo D, Lu B, et al
    Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese.
    Proc Natl Acad Sci U S A. 2015 Jun 15. pii: 201424063.
    PubMed     Text format     Abstract available


    March 2015
  44. DEANGELIS DL, Yurek S
    Equation-free modeling unravels the behavior of complex ecological systems.
    Proc Natl Acad Sci U S A. 2015;112:3856-7.
    PubMed     Text format    


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